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Title:
NANOFIBERS
Document Type and Number:
WIPO Patent Application WO/2023/145886
Kind Code:
A1
Abstract:
The present invention provides nanofibers which control the elution behavior of a water-soluble medical polymer and make the water-soluble medical polymer sustained-release, and a production method for the nanofibers. The nanofibers according to the present invention are nanofibers including a polyvinyl alcohol resin and the water-soluble medical polymer, wherein the molecular weight of the water-soluble medical polymer is 1,000 to 50,000, or are nanofibers including a polyvinyl alcohol resin and the water-soluble medical polymer, wherein the water-soluble medical polymer is a protein pharmaceutical.

Inventors:
TAHARA KOHEI (JP)
OGAWA RIHO (JP)
KOBAYASHI AYAKA (JP)
YOSHIMURA NOBUYOSHI (JP)
TANIGUCHI YUTAKA (JP)
Application Number:
PCT/JP2023/002672
Publication Date:
August 03, 2023
Filing Date:
January 27, 2023
Export Citation:
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Assignee:
MITSUBISHI CHEM CORP (JP)
International Classes:
A61K47/32; A61K38/00; A61K38/46; D01D5/04; D01D5/08; D01F6/14; D01F6/50; D04H1/4309; D04H1/728
Domestic Patent References:
WO2009031620A12009-03-12
Foreign References:
JP2005534716A2005-11-17
JP2014055119A2014-03-27
JP2021088552A2021-06-10
JP2003521493A2003-07-15
Other References:
SEIF SALEM, PLANZ VIKTORIA, WINDBERGS MAIKE: "Controlling the Release of Proteins from Therapeutic Nanofibers: The Effect of Fabrication Modalities on Biocompatibility and Antimicrobial Activity of Lysozyme", PLANTA MEDICA, THIEME VERLAG, DE, vol. 83, no. 05, DE , pages 445 - 452, XP093080836, ISSN: 0032-0943, DOI: 10.1055/s-0042-109715
SANDEEP KUMAR TIWARI, VENKATRAMAN SUBBU: "Electrospinning pure protein solutions in core-shell fibers", POLYMER INTERNATIONAL, PUBLISHED FOR SCI BY ELSEVIER APPLIED SCIENCE, vol. 61, no. 10, 1 October 2012 (2012-10-01), pages 1549 - 1555, XP055038285, ISSN: 09598103, DOI: 10.1002/pi.4246
WANG, Y. HSIEH, Y.L.: "Immobilization of lipase enzyme in polyvinyl alcohol (PVA) nanofibrous membranes", JOURNAL OF MEMBRANE SCIENCE, ELSEVIER BV, NL, vol. 309, no. 1-2, 11 October 2007 (2007-10-11), NL , pages 73 - 81, XP022400958, ISSN: 0376-7388
Attorney, Agent or Firm:
EIKOH, P.C. (JP)
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