Title:
NANOFIBROUS MATERIAL PARTICULARLY FOR TOPICAL USE IN THERAPIES
Document Type and Number:
WIPO Patent Application WO/2021/244684
Kind Code:
A1
Abstract:
The invention discloses nanofibrous material particularly for topical use in therapies consisting of compound chosen from a group comprising lipophosphonoxins of general formula I, wherein R1 is (C8–C22)alkyl, hexadecyloxypropyl, tetradecyloxypropyl, tetradecyloxyethyl, or hexadecyloxyethyl, R2 is uracil, thymine, or cytosine, and R3 is primary, secondary, or tertiary amine, diastereomers and mixtures of diastereomers of compounds according to formula I, and their pharmaceutically acceptable salts and hydrates, incorporated into polyester-based nanofibers of general formula II, wherein m has a value of at least 1, and R is -H or (C1–C10)alkyl, or copolymers thereof.
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Inventors:
ZAJICEK ROBERT (CZ)
GAL PETER (SK)
REJMAN DOMINIK (CZ)
DO PHAM DUY DINH (CZ)
MOJR VIKTOR (CZ)
HAVLICKOVA KRISTYNA (CZ)
JENCOVA VERA (CZ)
LUKAS DAVID (CZ)
ASATIANI NIKIFOR (CZ)
MIKES PETR (CZ)
KUZELOVA KOSTAKOVA EVA (CZ)
GAL PETER (SK)
REJMAN DOMINIK (CZ)
DO PHAM DUY DINH (CZ)
MOJR VIKTOR (CZ)
HAVLICKOVA KRISTYNA (CZ)
JENCOVA VERA (CZ)
LUKAS DAVID (CZ)
ASATIANI NIKIFOR (CZ)
MIKES PETR (CZ)
KUZELOVA KOSTAKOVA EVA (CZ)
Application Number:
PCT/CZ2021/050055
Publication Date:
December 09, 2021
Filing Date:
May 25, 2021
Export Citation:
Assignee:
UNIV KARLOVA (CZ)
USTAV ORGANICKE CHEMIE A BIOCHEMIE AKADEMIE VED CESKE REPUBLIKY V V I (CZ)
UNIV V LIBERCI TECCH (CZ)
USTAV ORGANICKE CHEMIE A BIOCHEMIE AKADEMIE VED CESKE REPUBLIKY V V I (CZ)
UNIV V LIBERCI TECCH (CZ)
International Classes:
A61L15/26; A61K9/00; A61L15/46
Domestic Patent References:
| WO2020037218A1 | 2020-02-20 |
Foreign References:
| EP2527351A1 | 2012-11-28 | |||
| EP3448865A1 | 2019-03-06 |
Other References:
GÁMEZ ENRIQUE ET AL: "Antimicrobial Electrospun Polycaprolactone-Based Wound Dressings: An In Vitro Study About the Importance of the Direct Contact to Elicit Bactericidal Activity", ADVANCES IN WOUND CARE, vol. 8, no. 9, 1 September 2019 (2019-09-01), pages 438 - 451, XP055831650, ISSN: 2162-1918, Retrieved from the Internet DOI: 10.1089/wound.2018.0893
ZBORNÍKOVÁ EVA ET AL: "Evaluation of Second-Generation Lipophosphonoxins as Antimicrobial Additives in Bone Cement", ACS OMEGA, vol. 5, no. 7, 25 February 2020 (2020-02-25), US, pages 3165 - 3171, XP055831651, ISSN: 2470-1343, Retrieved from the Internet DOI: 10.1021/acsomega.9b03072
J. ZENG ET AL., INFLUENCE OF THE DRUG COMPATIBILITY WITH POLYMER SOLUTION ON THE RELEASE KINETICS OF ELECTROSPUN FIBER FORMULATION
ZBORNÍKOVÁ EVA ET AL: "Evaluation of Second-Generation Lipophosphonoxins as Antimicrobial Additives in Bone Cement", ACS OMEGA, vol. 5, no. 7, 25 February 2020 (2020-02-25), US, pages 3165 - 3171, XP055831651, ISSN: 2470-1343, Retrieved from the Internet
J. ZENG ET AL., INFLUENCE OF THE DRUG COMPATIBILITY WITH POLYMER SOLUTION ON THE RELEASE KINETICS OF ELECTROSPUN FIBER FORMULATION
Attorney, Agent or Firm:
MACHU, Matej (CZ)
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