Title:
NANOFILTRATION OF FACTOR VII SOLUTIONS TO REMOVE VIRUS
Document Type and Number:
WIPO Patent Application WO2005054275
Kind Code:
A3
Abstract:
The present invention relates to a novel method for improving the viral safety of liquid Factor VII compositions, in particular those comprising active Factor VII polypeptides (a Factor VIIa polypeptide).
Inventors:
CHRISTENSEN JESPER (DK)
HALKJAER ERIK (DK)
PREUSS TURID (DK)
HANSEN THOMAS BUDDE (DK)
TOMODA LENE VAEDELE MADSEN (DK)
JOHANSEN NINA (DK)
HALKJAER ERIK (DK)
PREUSS TURID (DK)
HANSEN THOMAS BUDDE (DK)
TOMODA LENE VAEDELE MADSEN (DK)
JOHANSEN NINA (DK)
Application Number:
PCT/EP2004/053206
Publication Date:
September 09, 2005
Filing Date:
December 01, 2004
Export Citation:
Assignee:
NOVO NORDISK HEALTHCARE AG (CH)
CHRISTENSEN JESPER (DK)
HALKJAER ERIK (DK)
PREUSS TURID (DK)
HANSEN THOMAS BUDDE (DK)
TOMODA LENE VAEDELE MADSEN (DK)
JOHANSEN NINA (DK)
CHRISTENSEN JESPER (DK)
HALKJAER ERIK (DK)
PREUSS TURID (DK)
HANSEN THOMAS BUDDE (DK)
TOMODA LENE VAEDELE MADSEN (DK)
JOHANSEN NINA (DK)
International Classes:
C07K1/34; C07K14/745; C12N7/06; C12N9/64; (IPC1-7): C07K1/34; C07K14/745; C12N9/64; C12N7/06
Domestic Patent References:
| WO1998037086A1 | 1998-08-27 |
Foreign References:
| EP0131740A2 | 1985-01-23 | |||
| EP0549964A2 | 1993-07-07 |
Other References:
TOMOKIYO K ET AL: "Large-scale production and properties of human plasma-derived activated Factor VII concentrate", VOX SANGUINIS, S. KARGER AG, BASEL, CH, vol. 84, no. 1, January 2003 (2003-01-01), pages 54 - 64, XP002286502, ISSN: 0042-9007
BURNOUF T ET AL: "NANOFILTRATION OF PLASMA-DERIVED BIOPHARMACEUTICAL PRODUCTS", HAEMOPHILIA, BLACKWELL SCIENCE, OXFORD, GB, vol. 9, no. 1, January 2003 (2003-01-01), pages 24 - 37, XP001181709, ISSN: 1351-8216
EIGENBROT C: "STRUCTURE, FUNCTION, AND ACTIVATION OF COAGULATION FACTOR VII", CURRENT PROTEIN AND PEPTIDE SCIENCE, BENTHAM SCIENCE PULBISHERS, NL, vol. 3, no. 3, June 2002 (2002-06-01), pages 287 - 299, XP001153828, ISSN: 1389-2037
HOROWITZ B ET AL: "Virus inactivation by solvent/detergent treatment and the manufacture of SD-plasma.", VOX SANGUINIS. 1998, vol. 74 Suppl 1, 1998, pages 203 - 206, XP009048852, ISSN: 0042-9007
CHANDRA S ET AL: "EFFECTIVENESS OF ALTERNATIVE TREATMENTS FOR REDUCING POTENTIAL VIRAL CONTAMINANTS FROM PLASMA-DERIVED PRODUCTS", THROMBOSIS RESEARCH, TARRYTOWN, NY, US, vol. 105, no. 5, 1 March 2002 (2002-03-01), pages 391 - 400, XP001181710, ISSN: 0049-3848
BURNOUF T ET AL: "NANOFILTRATION OF PLASMA-DERIVED BIOPHARMACEUTICAL PRODUCTS", HAEMOPHILIA, BLACKWELL SCIENCE, OXFORD, GB, vol. 9, no. 1, January 2003 (2003-01-01), pages 24 - 37, XP001181709, ISSN: 1351-8216
EIGENBROT C: "STRUCTURE, FUNCTION, AND ACTIVATION OF COAGULATION FACTOR VII", CURRENT PROTEIN AND PEPTIDE SCIENCE, BENTHAM SCIENCE PULBISHERS, NL, vol. 3, no. 3, June 2002 (2002-06-01), pages 287 - 299, XP001153828, ISSN: 1389-2037
HOROWITZ B ET AL: "Virus inactivation by solvent/detergent treatment and the manufacture of SD-plasma.", VOX SANGUINIS. 1998, vol. 74 Suppl 1, 1998, pages 203 - 206, XP009048852, ISSN: 0042-9007
CHANDRA S ET AL: "EFFECTIVENESS OF ALTERNATIVE TREATMENTS FOR REDUCING POTENTIAL VIRAL CONTAMINANTS FROM PLASMA-DERIVED PRODUCTS", THROMBOSIS RESEARCH, TARRYTOWN, NY, US, vol. 105, no. 5, 1 March 2002 (2002-03-01), pages 391 - 400, XP001181710, ISSN: 0049-3848
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