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Title:
NANOLIPOSOME CONTAINING LUTEIN AND CORDYCEPS MILITARIS ALCOHOL EXTRACT, AND METHOD FOR PREPARATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/098174
Kind Code:
A1
Abstract:
Provided are a nanoliposome containing lutein and Cordyceps militaris alcohol extract, and a method for preparation thereof; the contained amount of Cordyceps militaris alcohol extract is 4%–8% by mass, and the mass ratio of lutein to Cordyceps militaris alcohol extract is 1:3–1:5. An ethanol injection method is combined with micro-jet technology to achieve co-loading of lutein and Cordyceps militaris alcohol extract, two active substances having different hydrophobicities, in a nanoliposome; the prepared liposome has a particle size of less than 200 nm, the loading rate of lutein is higher than 90%, the loading rate of Cordyceps militaris alcohol extract is higher than 85%, and stability is good; the preparation process is safe and simple, costs are low, facilitating industrial production.

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Inventors:
SONG JIANGFENG (CN)
XU PENGXIANG (CN)
DAI ZHUQING (CN)
WU CAIE (CN)
LI DAJING (CN)
LIU CHUNQUAN (CN)
ZHANG ZHONGYUAN (CN)
WANG KUN (CN)
Application Number:
PCT/CN2020/092080
Publication Date:
May 27, 2021
Filing Date:
May 25, 2020
Export Citation:
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Assignee:
JIANGSU ACAD AGRICULTURAL SCI (CN)
International Classes:
A23L33/00; A23P10/47; A61K9/127; A61K31/047; A61P9/00; A61P35/00
Foreign References:
CN102793177A2012-11-28
CN107927739A2018-04-20
CN105726482A2016-07-06
Other References:
JIAO YAN, DAJING LI, CHUNQUAN LIU, YADONG XIAO: "Lutein Nanoliposomes: Optimization of Preparation Conditions and Oxidative Stability", FOOD SCIENCE, vol. 38, no. 18, 15 February 2017 (2017-02-15), pages 259 - 265, XP055813535, ISSN: 1002-6630, DOI: 10.7506/spkx1002-6630-201718040
Attorney, Agent or Firm:
CHINA FARFIR INTELLECTUAL PROPERTY AGENCY (CN)
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