Title:
NANOPARTICLE, 5'-TRH COMPLEX, AND ANTI-CANCER COMPOSITION COMPRISING SAME
Document Type and Number:
WIPO Patent Application WO/2024/101945
Kind Code:
A1
Abstract:
The present invention relates to a nanoparticle, a nanoparticle complex comprising anti-5'-tRH-GlyGCC bound thereto, and a pharmaceutical composition for preventing or treating cancer comprising same. The present invention may provide an anti-cancer composition with an excellent effect of inhibiting cancer cell proliferation by utilizing the intracellular delivery capability of a nanoparticle.
Inventors:
LEE KANGSEOK (KR)
BAE JEEHYEON (KR)
YEOM JIHYUN (KR)
SIM SEHOON (KR)
JOO MINJU (KR)
SHIN EUNKYOUNG (KR)
HA YOONJIE (KR)
KIM HONGMAN (KR)
RYU MINKYUNG (KR)
BAE JEEHYEON (KR)
YEOM JIHYUN (KR)
SIM SEHOON (KR)
JOO MINJU (KR)
SHIN EUNKYOUNG (KR)
HA YOONJIE (KR)
KIM HONGMAN (KR)
RYU MINKYUNG (KR)
Application Number:
PCT/KR2023/018060
Publication Date:
May 16, 2024
Filing Date:
November 10, 2023
Export Citation:
Assignee:
NES BIOTECHNOLOGY CO LTD (KR)
International Classes:
A61K47/69; A61K31/711; A61P35/00; C12N15/113; C12Q1/6886
Foreign References:
| CN112501294A | 2021-03-16 | |||
| CN115305283A | 2022-11-08 |
Other References:
JI-HYUN YEOM: "5′-tRNAGly(GCC) halves generated by IRE1α are linked to ER stress response", RESEARCH SQUARE, 18 March 2022 (2022-03-18), XP093169819, Retrieved from the Internet DOI: 10.21203/rs.3.rs-1464849/v1
LE-TIAN HUANG: "Expression profiles of tRNA-derived fragments and their potential roles in lung adenocarcinoma", ANNALS OF TRANSLATIONAL MEDICINE, AME PUBLISHING COMPANY, US, vol. 10, no. 4, 1 February 2022 (2022-02-01), US , pages 196, XP093169822, ISSN: 2305-5839, DOI: 10.21037/atm-22-119
JI-HYUN YEOM: "Inhibition of Xenograft Tumor Growth by Gold Nanoparticle-DNA Oligonucleotide Conjugates-Assisted Delivery of BAX mRNA", PLOS ONE, PUBLIC LIBRARY OF SCIENCE, US, vol. 8, no. 9, US , pages e75369, XP093169824, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0075369
LE-TIAN HUANG: "Expression profiles of tRNA-derived fragments and their potential roles in lung adenocarcinoma", ANNALS OF TRANSLATIONAL MEDICINE, AME PUBLISHING COMPANY, US, vol. 10, no. 4, 1 February 2022 (2022-02-01), US , pages 196, XP093169822, ISSN: 2305-5839, DOI: 10.21037/atm-22-119
JI-HYUN YEOM: "Inhibition of Xenograft Tumor Growth by Gold Nanoparticle-DNA Oligonucleotide Conjugates-Assisted Delivery of BAX mRNA", PLOS ONE, PUBLIC LIBRARY OF SCIENCE, US, vol. 8, no. 9, US , pages e75369, XP093169824, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0075369
Attorney, Agent or Firm:
PADO IP LAW PLLC (KR)
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