Title:
NANOPARTICLE COMPOSITE SHOWING IMPROVED ENDOCYTOSIS EFFICIENCY THROUGH SURFACE MODIFICATION USING LIPID AND MANUFACTURING METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2019/231051
Kind Code:
A1
Abstract:
The present invention relates to a nanoparticle composite, which is endocytosed into cells and used to treat a disease, and to a manufacturing method therefor. More specifically, the present invention relates to a nanoparticle composite and a manufacturing method therefor, wherein the nanoparticle composite shows improved endocytosis efficiency by modifying the nanoparticle surface with a lipid-based material having high stability and excellent biocompatibility; the nanoparticle composite can attain direct passage through the cellular membrane as well as endocytosis, and can be effectively endocytosed into spheroid-shaped tumor cells, by having a tube-shaped lipid structure combined with a portion of the nanoparticle surface; and the nanoparticle composite can be easily mass-produced by using a top-down manner, in which, the lipid structure is not attached directly to the nanoparticle, but the binding of the nanoparticle and the lipid-based lipidome (bubble, liposome, etc.) is induced, and then the physical force is applied thereto to disrupt the lipidome, thereby forming the lipid structure on the nanoparticle surface.
Inventors:
KIM HYUN CHEOL (KR)
KIM DO YEON (KR)
KIM DO YEON (KR)
Application Number:
PCT/KR2018/010309
Publication Date:
December 05, 2019
Filing Date:
September 04, 2018
Export Citation:
Assignee:
UNIV SOGANG RES FOUNDATION (KR)
International Classes:
A61K9/50; A61K9/127; A61K9/51; A61K45/06; A61K47/69
Domestic Patent References:
| WO2015153805A2 | 2015-10-08 | |||
| WO2018064350A1 | 2018-04-05 |
Foreign References:
| KR101085203B1 | 2011-11-21 | |||
| KR20170040748A |
Other References:
SAHAY, G.: "Endocytosis of nanomedicines.", J. CONTROL RELEASE., 3 August 2010 (2010-08-03), XP027129701
LONGFA KOU, SUN JIN, ZHAI YINGLEI, HE ZHONGGUI: "The endocytosis and intracellular fate of nanomedicines : Implication for ration design", ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 8, no. 1, 14 February 2013 (2013-02-14), pages 1 - 10, XP055755633, ISSN: 1818-0876, DOI: 10.1016/j.ajps.2013.07.001
See also references of EP 3808344A4
LONGFA KOU, SUN JIN, ZHAI YINGLEI, HE ZHONGGUI: "The endocytosis and intracellular fate of nanomedicines : Implication for ration design", ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 8, no. 1, 14 February 2013 (2013-02-14), pages 1 - 10, XP055755633, ISSN: 1818-0876, DOI: 10.1016/j.ajps.2013.07.001
See also references of EP 3808344A4
Attorney, Agent or Firm:
KIM, Hyun Jin (KR)
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