Title:
NANOVACCINE AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2021/169484
Kind Code:
A1
Abstract:
A multi-component vector-free integrated nanovaccine constructed from an unsaturated fatty acid and containing an antigen peptide, an immunologic adjuvant, and a small molecule drug, and a method therefor. The nanovaccine contains an antigen, an immunologic adjuvant, and an unsaturated fatty acid, the antigen is covalently coupled to the unsaturated fatty acid by means of a -SH group, and the immunologic adjuvant is coupled to the unsaturated fatty acid by means of a S-S bond. The antigen peptide and the immunologic adjuvant which are tumor-targeting are modified with the unsaturated fatty acid, self-assembly is enabled in an aqueous solution by taking the unsaturated fatty acid as a hydrophobic core, and the small molecule drug having high hydrophobicity can be loaded in the hydrophobic core. The nanovaccine can prolong the residence time of the antigen peptide in a lymph gland, enhance endocytosis of DC cells for the antigen peptide, and improve the anti-tumor immune effect.
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Inventors:
QIAO YITING (CN)
ZHENG SHUSEN (CN)
CHEN JIANXIANG (CN)
ZHANG LELE (CN)
ZHENG SHUSEN (CN)
CHEN JIANXIANG (CN)
ZHANG LELE (CN)
Application Number:
PCT/CN2020/135527
Publication Date:
September 02, 2021
Filing Date:
December 11, 2020
Export Citation:
Assignee:
UNIV ZHEJIANG (CN)
International Classes:
A61K39/00; A61K39/39; A61K45/06; A61K47/54; A61P37/04
Domestic Patent References:
| WO2003105607A1 | 2003-12-24 |
Foreign References:
| CN111249453A | 2020-06-09 | |||
| CN102481375A | 2012-05-30 | |||
| CN105617394A | 2016-06-01 | |||
| EP2630967A1 | 2013-08-28 | |||
| CN109021078A | 2018-12-18 | |||
| CN110314136A | 2019-10-11 | |||
| CN109069569A | 2018-12-21 | |||
| CN102068698A | 2011-05-25 |
Other References:
WANG YING, ZHAO KAI: "Development and Application of Nanoparticles in Vaccine", CHEMICAL ENGINEERING DESIGN COMMUNICATIONS, vol. 43, no. 3, 31 March 2017 (2017-03-31), pages 57 - 57, XP055840545, ISSN: 1003-4690
JUN YANG, ZHIHUA LI, JIAJIA ZHOU, RUFU CHEN, LIANG ZHENG CHENG, QUAN BO ZHOU , LIQUN YANG: "Preparation and antitumor effects of nanovaccines with MAGE-3 peptides in transplanted gastric cancer in mice", ATZHENG -CHINESE JOURNAL OF CANCER, GAI KAN BIANJIBU, GUANGZHOU, CN, vol. 29, no. 4, 1 April 2010 (2010-04-01), CN, pages 359 - 364, XP009162306, ISSN: 1000-467X, DOI: 10.5732/cjc.009.10541
MANDAL ABHIRUP; PATEL PRATIKKUMAR; PAL DHANANJAY; MITRA ASHIM K.: "Multi-Layered Nanomicelles as Self-Assembled Nanocarrier Systems for Ocular Peptide Delivery", AAPS PHARMSCITECH, SPRINGER INTERNATIONAL PUBLISHING, CHAM, vol. 20, no. 2, 9 January 2019 (2019-01-09), Cham, XP037176864, DOI: 10.1208/s12249-018-1267-x
JUN YANG, ZHIHUA LI, JIAJIA ZHOU, RUFU CHEN, LIANG ZHENG CHENG, QUAN BO ZHOU , LIQUN YANG: "Preparation and antitumor effects of nanovaccines with MAGE-3 peptides in transplanted gastric cancer in mice", ATZHENG -CHINESE JOURNAL OF CANCER, GAI KAN BIANJIBU, GUANGZHOU, CN, vol. 29, no. 4, 1 April 2010 (2010-04-01), CN, pages 359 - 364, XP009162306, ISSN: 1000-467X, DOI: 10.5732/cjc.009.10541
MANDAL ABHIRUP; PATEL PRATIKKUMAR; PAL DHANANJAY; MITRA ASHIM K.: "Multi-Layered Nanomicelles as Self-Assembled Nanocarrier Systems for Ocular Peptide Delivery", AAPS PHARMSCITECH, SPRINGER INTERNATIONAL PUBLISHING, CHAM, vol. 20, no. 2, 9 January 2019 (2019-01-09), Cham, XP037176864, DOI: 10.1208/s12249-018-1267-x
Attorney, Agent or Firm:
HANGZHOU QIUSHI PATENT OFFICE CO., LTD. (CN)
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