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Title:
NANOVESICLES DERIVED FROM BACTERIA OF LACTOCOCCUS GENUS AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/156449
Kind Code:
A1
Abstract:
The present invention relates to vesicles derived from bacteria of the Lactococcus genus and a use thereof. The inventors thereof have experimentally confirmed that the vesicles are significantly reduced in samples obtained from patients with diabetes, myocardial infarction, atrial fibrillation, cerebral infarction, renal failure, Parkinson's disease and depression compared to healthy individuals, and that the vesicles inhibit the secretion of an inflammatory mediator due to pathogenic vesicles. Thus, the vesicles derived from bacteria of the Lactococcus genus according to the present invention may be useful for the purpose of developing a method for diagnosing diabetes, myocardial infarction, atrial fibrillation, cerebral infarction, renal failure, Parkinson's disease or depression, and a composition for preventing or treating the diseases or an inflammatory disease.

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Inventors:
KIM YOON-KEUN (KR)
PARK HAE-SIM (KR)
Application Number:
PCT/KR2019/001439
Publication Date:
August 15, 2019
Filing Date:
February 01, 2019
Export Citation:
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Assignee:
MD HEALTHCARE INC (KR)
UNIV AJOU IND ACADEMIC COOP FOUND (KR)
International Classes:
C12Q1/689; A23L33/135; A61K35/747; A61P3/10; A61P9/10; A61P25/00; A61P25/18; C12Q1/6851
Foreign References:
KR20170015958A2017-02-10
US20170327863A12017-11-16
KR20160073157A2016-06-24
JP2016525355A2016-08-25
Other References:
SLYEPCHENKO, A.: "Gut Microbiota, Bacterial Translocation, and Interactions with Diet: Pathophysiological Links between Major Depressive Disorder and Non-Communicable Medical Comorbidities", PSYCHOTHER. PSYCHOSOM., vol. 86, no. 1, 2017, pages 31 - 46, XP055630869
See also references of EP 3751008A4
Attorney, Agent or Firm:
LEE, Myoung-Jin (KR)
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