Title:
NANOVESICLES DERIVED FROM MICROCOCCUS BACTERIA AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/168327
Kind Code:
A1
Abstract:
The present invention relates to vesicles derived from Micrococcus bacteria and a use thereof. The present inventors have confirmed experimentally that the vesicles were significantly reduced in samples of patients with gastric cancer, pancreatic cancer, bile duct cancer, breast cancer, ovarian cancer, bladder cancer, myocardial infarction, cardiomyopathy, atrial fibrillation, variant angina, chronic obstructive pulmonary disease (COPD), dementia, and diabetes compared to a normal person, and that, when vesicles separated from the strain were injected, the secretion of an inflammatory mediator by pathogenic vesicles such as vesicles derived from Escherichia coli was remarkably inhibited. Therefore, the vesicles derived from Micrococcus bacteria according to the present invention may be usefully used for the purpose of developing a method for diagnosing gastric cancer, pancreatic cancer, bile duct cancer, breast cancer, ovarian cancer, bladder cancer, myocardial infarction, cardiomyopathy, atrial fibrillation, variant angina, COPD, dementia, or diabetes and a composition for preventing, alleviating, or treating the diseases.
Inventors:
KIM YOON-KEUN (KR)
Application Number:
PCT/KR2019/002341
Publication Date:
September 06, 2019
Filing Date:
February 27, 2019
Export Citation:
Assignee:
MD HEALTHCARE INC (KR)
International Classes:
C12Q1/689; A23L33/135; A61K35/74
Foreign References:
| KR20160073157A | 2016-06-24 | |||
| KR20110038575A | 2011-04-14 | |||
| KR20180018354A | 2018-02-21 | |||
| KR20180006303A | 2018-01-17 | |||
| KR20110025603A | 2011-03-10 | |||
| JP5313659B2 | 2013-10-09 |
Other References:
See also references of EP 3760742A4
Attorney, Agent or Firm:
LEE, Myoung-Jin (KR)
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