Title:
NAPHTHOQUINONE DERIVATIVES FOR THE TREATMENT OF CHRONIC INFLAMMATION
Document Type and Number:
WIPO Patent Application WO1992013532
Kind Code:
A3
Abstract:
PCT No. PCT/GB92/00196 Sec. 371 Date Jul. 12, 1993 Sec. 102(e) Date Jul. 12, 1993 PCT Filed Feb. 3, 1992 PCT Pub. No. WO92/01353 PCT Pub. Date Aug. 20, 1992A redox, hydrogen-acceptor compound, having utility in treating inflammation, is a 1,4-dioxonaphthalene or 1,4-dilminon aphthalene having either a 2,3-double bond, in which cast there are 2 and 3-substituents, or a 2,3-single bond. Examples of such compounds are menadione epoxide and water-soluble derivatives or menadione such as menadione bisulphite.
Inventors:
CHAYEN JOSEPH (GB)
BITENSKY LUCILLE (GB)
FROST GEORGE THOMAS BAXTER (GB)
BITENSKY LUCILLE (GB)
FROST GEORGE THOMAS BAXTER (GB)
Application Number:
PCT/GB1992/000196
Publication Date:
October 29, 1992
Filing Date:
February 03, 1992
Export Citation:
Assignee:
CHAYEN JOSEPH (GB)
BITENSKY LUCILLE (GB)
FROST GEORGE THOMAS BAXTER (GB)
BITENSKY LUCILLE (GB)
FROST GEORGE THOMAS BAXTER (GB)
International Classes:
A61K31/12; A61K31/122; A61K31/135; A61K31/185; A61K31/336; A61K31/365; A61K31/366; A61K31/39; A61P29/00; C07C49/323; C07C309/25; C07D303/32; (IPC1-7): A61K31/365; A61K31/39; A61K31/12
Foreign References:
| EP0147778A2 | 1985-07-10 |
Other References:
Agents & Actions, volume 12, no. 4, 1982, Birkhauser Verlag, Basel, CH; J. Chayen: "Editorial concerning the possibility of redox drugs", pages 530-535 (cited in the application)
The Journal of Rheumatology, volume 11, no. 5, October 1984; F. Huck et al.: "Reducing property of some slow acting antirheumatic drugs", pages 605-609
The Journal of Rheumatology, volume 11, no. 5, October 1984; F. Huck et al.: "Reducing property of some slow acting antirheumatic drugs", pages 605-609
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