Title:
NEPHROPROTECTIVE USEFUL AGENT
Document Type and Number:
WIPO Patent Application WO/2023/189402
Kind Code:
A1
Abstract:
[Problem] The purpose of the present invention is to further develop the invention of useful agents having 3,5-dihydroxy-4-methoxybenzyl alcohol as an active ingredient, which the present inventor has already acquired, and to provide useful agents, such as a nephroprotective useful agent having a nephroprotective useful effect, having 3,5-dihydroxy-4-methoxybenzyl alcohol as an active ingredient. [Solution] The present invention is characterized by having a nephroprotective useful effect and having 3,5-dihydroxy-4-methoxybenzyl alcohol as an active ingredient.
Inventors:
WATANABE MITSUGU (JP)
CHIBA HITOSHI (JP)
KEI SHUKUHEI (JP)
KA KIN-YOU (JP)
SAKURAI TOSHIHIRO (JP)
WATANABE HIDEAKI (JP)
CHIBA HITOSHI (JP)
KEI SHUKUHEI (JP)
KA KIN-YOU (JP)
SAKURAI TOSHIHIRO (JP)
WATANABE HIDEAKI (JP)
Application Number:
PCT/JP2023/009236
Publication Date:
October 05, 2023
Filing Date:
March 10, 2023
Export Citation:
Assignee:
WATANABE OYSTER LABORATORY CO LTD (JP)
International Classes:
A61K31/085; A61P13/12; A61P39/06; A61P43/00
Foreign References:
| JP2017132753A | 2017-08-03 |
Other References:
MITSUGU WATANABE ET AL.: "Antioxidant and stress-reducing effects of 3,5-dihydroxy-4-methoxybenzyl alcohol (DHMBA), a phenolic antioxidant contained in oyster soft body extract, on oxidatively stressed mice", JAPANESE PHARMACOLOGY AND THERAPEUTICS, RAIFU SAIENSU SHUPPAN, TOKYO., JP, vol. 45, no. 1, 1 January 2017 (2017-01-01), JP , pages 25 - 33, XP009549732, ISSN: 0386-3603
WATANABE, MITSUGU ET AL. : "LS1: About research and development of Watanabe Oyster DHMBA (Diva) Jelly, food with functional claims", ABSTRACTS OF THE 26TH ACADEMIC MEETING OF THE JAPANESE SOCIETY FOR MIBYO SYSTEMS (JMSA), vol. 26, 1 January 2019 (2019-01-01), pages 79, XP009549749
HIROTOSHI FUTA ET AL.: "Antioxidant ability of oyster-derived antioxidant using human renal proximal tubular epithelial cells", JAPANESE JOURNAL OF CLINICAL CHEMISTRY, JAPANESE ASSOCIATION OF CLINICAL CHEMISTS, OSAKA, JP, vol. 48, no. Suppl. 1, 1 January 2019 (2019-01-01), JP , pages 248, XP009549750, ISSN: 0370-5633
YOSHINORI KISHIDA ET AL.: "Expression level analysis of antioxidant enzymes using proteomics", JAPANESE JOURNAL OF CLINICAL CHEMISTRY, JAPANESE ASSOCIATION OF CLINICAL CHEMISTS, OSAKA, JP, vol. 46, no. Suppl. 1, 1 January 2017 (2017-01-01), JP , pages 347, XP009549751, ISSN: 0370-5633
YI-JOU WU, HSIN-JUNG HO, ZHEN CHEN, JIAPING JIA, NATSUMI AOKI, HITOSHI CHIBA, TAKAYUKI WATANABE, MITSUGU WATANABE, SHAPING HUI: "Alteration of cardiolipin profile in HK-2 proximal tubule cells underoxidative stress and the reverse effects of 3,5-dihydroxy-4methoxybenzyl alcohol (DHMBA)", JSBMS LETTERS, JAPANESE SOCIETY FOR BIOMEDICAL MASS SPECTROMETRY, JP, vol. 46, no. Suppl., 1 January 2021 (2021-01-01), JP , pages 106, XP009549742, ISSN: 1881-5464
MAO RUI‐WEN, HE SHAN‐PING, LAN JUN‐GANG, ZHU WU‐ZHENG: "Honokiol ameliorates cisplatin‐induced acute kidney injury via inhibition of mitochondrial fission", BRITISH JOURNAL OF PHARMACOLOGY, WILEY-BLACKWELL, UK, vol. 179, no. 14, 1 July 2022 (2022-07-01), UK , pages 3886 - 3904, XP093096130, ISSN: 0007-1188, DOI: 10.1111/bph.15837
ZHU CHAO; TIAN LIUYANG; YANG HUANWAN; CHEN PU; LI YANG; LIU YUQI: "Mitochondrial outer membrane voltage-dependent anion channel is involved in renal dysfunction in a spontaneously hypertensive rat carrying transfer RNA mutations", EUROPEAN JOURNAL OF PHARMACOLOGY, ELSEVIER SCIENCE, NL, vol. 865, 13 October 2019 (2019-10-13), NL , XP085938292, ISSN: 0014-2999, DOI: 10.1016/j.ejphar.2019.172622
SON SUNG HYUN, LEE SU MI, LEE MI HWA, SON YOUNG KI, KIM SEONG EUN, AN WON SUK: "Omega-3 Fatty Acids Upregulate SIRT1/3, Activate PGC-1α via Deacetylation, and Induce Nrf1 Production in 5/6 Nephrectomy Rat Model", MARINE DRUGS, vol. 19, no. 4, 26 March 2021 (2021-03-26), pages 182, XP093096132, DOI: 10.3390/md19040182
WATANABE, MITSUGU ET AL. : "LS1: About research and development of Watanabe Oyster DHMBA (Diva) Jelly, food with functional claims", ABSTRACTS OF THE 26TH ACADEMIC MEETING OF THE JAPANESE SOCIETY FOR MIBYO SYSTEMS (JMSA), vol. 26, 1 January 2019 (2019-01-01), pages 79, XP009549749
HIROTOSHI FUTA ET AL.: "Antioxidant ability of oyster-derived antioxidant using human renal proximal tubular epithelial cells", JAPANESE JOURNAL OF CLINICAL CHEMISTRY, JAPANESE ASSOCIATION OF CLINICAL CHEMISTS, OSAKA, JP, vol. 48, no. Suppl. 1, 1 January 2019 (2019-01-01), JP , pages 248, XP009549750, ISSN: 0370-5633
YOSHINORI KISHIDA ET AL.: "Expression level analysis of antioxidant enzymes using proteomics", JAPANESE JOURNAL OF CLINICAL CHEMISTRY, JAPANESE ASSOCIATION OF CLINICAL CHEMISTS, OSAKA, JP, vol. 46, no. Suppl. 1, 1 January 2017 (2017-01-01), JP , pages 347, XP009549751, ISSN: 0370-5633
YI-JOU WU, HSIN-JUNG HO, ZHEN CHEN, JIAPING JIA, NATSUMI AOKI, HITOSHI CHIBA, TAKAYUKI WATANABE, MITSUGU WATANABE, SHAPING HUI: "Alteration of cardiolipin profile in HK-2 proximal tubule cells underoxidative stress and the reverse effects of 3,5-dihydroxy-4methoxybenzyl alcohol (DHMBA)", JSBMS LETTERS, JAPANESE SOCIETY FOR BIOMEDICAL MASS SPECTROMETRY, JP, vol. 46, no. Suppl., 1 January 2021 (2021-01-01), JP , pages 106, XP009549742, ISSN: 1881-5464
MAO RUI‐WEN, HE SHAN‐PING, LAN JUN‐GANG, ZHU WU‐ZHENG: "Honokiol ameliorates cisplatin‐induced acute kidney injury via inhibition of mitochondrial fission", BRITISH JOURNAL OF PHARMACOLOGY, WILEY-BLACKWELL, UK, vol. 179, no. 14, 1 July 2022 (2022-07-01), UK , pages 3886 - 3904, XP093096130, ISSN: 0007-1188, DOI: 10.1111/bph.15837
ZHU CHAO; TIAN LIUYANG; YANG HUANWAN; CHEN PU; LI YANG; LIU YUQI: "Mitochondrial outer membrane voltage-dependent anion channel is involved in renal dysfunction in a spontaneously hypertensive rat carrying transfer RNA mutations", EUROPEAN JOURNAL OF PHARMACOLOGY, ELSEVIER SCIENCE, NL, vol. 865, 13 October 2019 (2019-10-13), NL , XP085938292, ISSN: 0014-2999, DOI: 10.1016/j.ejphar.2019.172622
SON SUNG HYUN, LEE SU MI, LEE MI HWA, SON YOUNG KI, KIM SEONG EUN, AN WON SUK: "Omega-3 Fatty Acids Upregulate SIRT1/3, Activate PGC-1α via Deacetylation, and Induce Nrf1 Production in 5/6 Nephrectomy Rat Model", MARINE DRUGS, vol. 19, no. 4, 26 March 2021 (2021-03-26), pages 182, XP093096132, DOI: 10.3390/md19040182
Attorney, Agent or Firm:
ITO, Giichiro (JP)
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