Title:
NERVE CELL DEATH INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2011/065480
Kind Code:
A1
Abstract:
Provided is a novel nerve cell death inhibitor which has an effect of inhibiting delayed nerve cell death caused by transient ischemia. Specifically provided is a drug for inhibiting delayed nerve cell death caused by transient ischemia, which contains cyclic phosphatidic acid or carbacyclic phosphatidic acid or a salt thereof.
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Inventors:
MUROFUSHI KIMIKO (JP)
KANASHIKI HARUMI (JP)
MUROFUSHI HIROMU (JP)
GOTOH MARI (JP)
KAKIUCHI YASUTAKA (JP)
KOBAYASHI SUSUMU (JP)
KANASHIKI HARUMI (JP)
MUROFUSHI HIROMU (JP)
GOTOH MARI (JP)
KAKIUCHI YASUTAKA (JP)
KOBAYASHI SUSUMU (JP)
Application Number:
PCT/JP2010/071127
Publication Date:
June 03, 2011
Filing Date:
November 26, 2010
Export Citation:
Assignee:
OCHANOMIZU UNIVERSITY (JP)
SANSHO CO (JP)
MUROFUSHI KIMIKO (JP)
KANASHIKI HARUMI (JP)
MUROFUSHI HIROMU (JP)
GOTOH MARI (JP)
KAKIUCHI YASUTAKA (JP)
KOBAYASHI SUSUMU (JP)
SANSHO CO (JP)
MUROFUSHI KIMIKO (JP)
KANASHIKI HARUMI (JP)
MUROFUSHI HIROMU (JP)
GOTOH MARI (JP)
KAKIUCHI YASUTAKA (JP)
KOBAYASHI SUSUMU (JP)
International Classes:
A61K31/661; A61K31/662; A61P25/00; A61P25/28; A61P43/00
Domestic Patent References:
| WO2000009139A2 | 2000-02-24 |
Foreign References:
| JP2002308779A | 2002-10-23 | |||
| JP2002308778A | 2002-10-23 | |||
| JP2002540146A | 2002-11-26 |
Other References:
FUJIWARA, YUKO ET AL.: "Cyclic phosphatidic acid elicits neurotrophin-like actions in embryonic hippocampal neurons", JOURNAL OF NEUROCHEMISTRY, vol. 87, no. 5, 2003, pages 1272 - 1283
SHIGENO, TAKU ET AL.: "Amelioration of Delayed Neuronal Death in the Hippocampus by Nerve Growth Factor", THE JOURNAL OF NEUROSCIENCE, vol. 11, no. 9, 1991, pages 2914 - 2919
ABE, KOJI: "Therapeutic Potential of Neurotrophic Factors and Neural Stem Cells Against Ischemic Brain Injury", JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, vol. 20, 2000, pages 1393 - 1408
HOTTA, HARUMI ET AL.: "Cyclic phosphatidic acid stimulates respiration without producing vasopressor or tachycardiac effects in rats", EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 543, no. 1-3, 2006, pages 27 - 31
GOTOH, MARI ET AL.: "Effects of cyclic phosphatidic acid on delayed neuronal death following transient ischemia in rat hippocampal CA1", EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 649, no. 1-3, 2010, pages 206 - 209
SHIGENO, TAKU ET AL.: "Amelioration of Delayed Neuronal Death in the Hippocampus by Nerve Growth Factor", THE JOURNAL OF NEUROSCIENCE, vol. 11, no. 9, 1991, pages 2914 - 2919
ABE, KOJI: "Therapeutic Potential of Neurotrophic Factors and Neural Stem Cells Against Ischemic Brain Injury", JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, vol. 20, 2000, pages 1393 - 1408
HOTTA, HARUMI ET AL.: "Cyclic phosphatidic acid stimulates respiration without producing vasopressor or tachycardiac effects in rats", EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 543, no. 1-3, 2006, pages 27 - 31
GOTOH, MARI ET AL.: "Effects of cyclic phosphatidic acid on delayed neuronal death following transient ischemia in rat hippocampal CA1", EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 649, no. 1-3, 2010, pages 206 - 209
Attorney, Agent or Firm:
SIKs & Co. (JP)
Patent business corporation patent firm Sykes (JP)
Patent business corporation patent firm Sykes (JP)
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