Title:
NEUREGULIN-4 ANALOGS AND METHODS OF USING THEREOF IN DISEASE TREATMENT
Document Type and Number:
WIPO Patent Application WO/2023/150693
Kind Code:
A3
Abstract:
Compositions of polypeptides are provided, which are analogs of neuregulin-4 and exhibit one or more activities of neuregulin-4, including the ability to induce homodimerization of ErbB4 subunits, the specificity in inducing homodimerization of ErbB4 over heterodimerization of ErbB family subunits. Various polypeptides described herein possess stability against enzymatic degradation. Methods of treating or reducing the likelihood of inflammatory bowel diseases are also provided using polypeptides that are analogs of human neuregulin-4.
Inventors:
GHOSH SOUMITRA (US)
LITZINGER DAVID (US)
ASADOURIAN ARTIN (US)
LITZINGER DAVID (US)
ASADOURIAN ARTIN (US)
Application Number:
PCT/US2023/061959
Publication Date:
September 28, 2023
Filing Date:
February 03, 2023
Export Citation:
Assignee:
AVEXEGEN THERAPEUTICS INC (US)
International Classes:
C07K14/475; A61K38/00
Domestic Patent References:
| WO2020205840A1 | 2020-10-08 |
Attorney, Agent or Firm:
HUBER, Linda B. et al. (US)
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