Title:
NEUROPROTECTIVE, ANTITHROMBOTIC AND ANTI-INFLAMMATORY USES OF ACTIVATED PROTEIN C (APC)
Document Type and Number:
WIPO Patent Application WO2001056532
Kind Code:
A9
Abstract:
The present invention provides methods for treating subjects having or at risk of having a neuropathological disorder or brain inflammatory diseases with and without vascular involvement, and systemic inflammatory vascular disease by administering a therapeutically effective amount of Activated Protein C (APC) to the subject. Brain disorders and brain inflammatory vascular diseases that can be treated by the invention method include all neurodegenerative diseases with different types of neuronal dysfunction, including stroke, Alzheimer's disease, Parkinson's disease, Huntington disease, neuroimmunological disorders such as multiple sclerosis and Gullian-Barre, encephalitis, meningitis, as well as other peripheral vascular diseases, such as diabetes, hypertension, artheriosclerosis. Also included are methods of treatment using APC in combination with a co-factor, such as Protein S.
Inventors:
GRIFFIN JOHN H (US)
ZLOKOVIC BERISLAV Y (US)
ZLOKOVIC BERISLAV Y (US)
Application Number:
PCT/US2001/003758
Publication Date:
January 09, 2003
Filing Date:
February 05, 2001
Export Citation:
Assignee:
SCRIPPS RESEARCH INST (US)
UNIV SOUTHERN CALIFORNIA (US)
GRIFFIN JOHN H (US)
ZLOKOVIC BERISLAV Y (US)
UNIV SOUTHERN CALIFORNIA (US)
GRIFFIN JOHN H (US)
ZLOKOVIC BERISLAV Y (US)
International Classes:
A61K38/48; A61K38/49; A61P9/02; A61K45/00; A61P9/10; A61P25/08; A61P25/16; A61P25/28; A61P29/00; A61P43/00; C12N9/64; A61K38/00; (IPC1-7): A61K38/00; A61K38/43; A61K39/00; C07K2/00
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