NEUROTROPHIC FACTOR EXPRESSION-INDUCING AGENT

Title:

NEUROTROPHIC FACTOR EXPRESSION-INDUCING AGENT

Document Type and Number:

WIPO Patent Application WO/2001/073024

Kind Code:

A1

Abstract:

It is found out that the culture supernatant of COS cells wherein PSEC56 gene is expressed has a neurite outgrowth effect. It is further clarified that this activity of the culture supernatant is brought about by NGF contained therein. Thus, it is found out that PSEC56 is usable as a neurotrophic factor expression-inducing agent and that the induction system of the NGF is applicable to the development of drugs for neural diseases.

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Inventors:

MITSUMORI CRISTINA (JP)
MORIKAWA NORIYUKI (JP)
HAYASHI KOJI (JP)
NAGAHARI KENJI (JP)
OTA TOSHIO (JP)
HIO YURI (JP)
NISHIKAWA TETSUO (JP)
ISOGAI TAKAO (JP)
KAWASAKI MASAKAZU (JP)
HASHIMOTO KENJI (JP)
KISHIMOTO TOSHIMITSU (JP)

Application Number:

PCT/JP2001/002768

Publication Date:

October 04, 2001

Filing Date:

March 30, 2001

Export Citation:

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Assignee:

HELIX RES INST (JP)
WELFIDE CORP (JP)
MITSUMORI CRISTINA (JP)
MORIKAWA NORIYUKI (JP)
HAYASHI KOJI (JP)
NAGAHARI KENJI (JP)
OTA TOSHIO (JP)
HIO YURI (JP)
NISHIKAWA TETSUO (JP)
ISOGAI TAKAO (JP)
KAWASAKI MASAKAZU (JP)
HASHIMOTO KENJI (JP)
KISHIMOTO TOSHIMITSU (JP)

International Classes:

C07K14/47; C12N15/12; A61K38/00; (IPC1-7): C12N15/12; C12N15/67; C07K14/48; C12Q1/02

Domestic Patent References:

WO1998012305A1

1998-03-26

Foreign References:

US5989860A

1999-11-23

Other References:

SATOSHI FUKUMOTO ET AL.: "GD3 synthase gene expression in PC12 cells results in the continuous activation of TrkA and ERK1/2 and enhanced proliferation", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 275, no. 8, February 2000 (2000-02-01), pages 5832 - 5838, XP002942020
See also references of EP 1283262A4

Attorney, Agent or Firm:

Shimizu, Hatsushi (1-1-1 Oroshi-mach, Tsuchiura-shi Ibaraki, JP)

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