Title:
NEUTRALIZING ANTIBODIES AGAINST COVID-19 AND METHODS OF USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/179561
Kind Code:
A1
Abstract:
Disclosed are compositions and methods using antibodies and antibody fragments that bind SARS-CoV-2 receptor binding domain (RBD). In particular, disclosed are antibodies and antigen binding fragments thereof comprising six complementarity determining regions (CDRs), wherein the CDRs comprise: (1) the three light chain CDRs of SEQ ID NO: 5 and the three heavy chain CDRs of SEQ ID NO: 1, (2) the three light chain CDRs of SEQ ID NO: 6 and the three heavy chain CDRs of SEQ ID NO: 2, (3) the three light chain CDRs of SEQ ID NO: 7 and the three heavy chain CDRs of SEQ ID NO: 3, or (4) the three light chain CDRs of SEQ ID NO: 8 and the three heavy chain CDRs of SEQ ID NO: 4and wherein the antibody or antigen binding fragment thereof binds to SARS-CoV-2 RBD.
Inventors:
CHEN ZHIWEI (CN)
ZHOU BIAO (CN)
ZHOU RUNHONG (CN)
CHAN FUK WOO (CN)
YUEN KWOK YUNG (CN)
ZHOU BIAO (CN)
ZHOU RUNHONG (CN)
CHAN FUK WOO (CN)
YUEN KWOK YUNG (CN)
Application Number:
PCT/CN2022/077669
Publication Date:
September 01, 2022
Filing Date:
February 24, 2022
Export Citation:
Assignee:
UNIV HONG KONG (CN)
CENTRE FOR VIROLOGY VACCINOLOGY AND THERAPEUTICS LTD (CN)
CENTRE FOR VIROLOGY VACCINOLOGY AND THERAPEUTICS LTD (CN)
International Classes:
C07K16/10; A61K39/42; A61P31/14; C12N15/13
Foreign References:
| CN111690059A | 2020-09-22 | |||
| CN111718411A | 2020-09-29 | |||
| CN111732654A | 2020-10-02 | |||
| CN111732655A | 2020-10-02 | |||
| CN111647076A | 2020-09-11 | |||
| CN111909260A | 2020-11-10 | |||
| CN111909263A | 2020-11-10 | |||
| CN111909262A | 2020-11-10 | |||
| CN111909261A | 2020-11-10 |
Attorney, Agent or Firm:
LIU, SHEN & ASSOCIATES (CN)
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