received by the International Bureau on 20 August 2020 (20.08.2020)

1 . A chemical compound comprising an ammonium salt of partially fluorinated organic acids, represented by the general formula 1

Cation (+)

where:

C_XF_2X - is a straight chain, where X = 6 to 10;

C_yH_2y - is a straight chain, where Y = 1 to 2;

C_ZH_2Z - is a straight chain, where Z = 0 to 10;

G is a bond or a S atom or a carbonyloxy group (OCO),

A is a bond or -OCO-C_zH_2z-, where Z = 0 to 3 or -OCO-Ar-, where Ar is benzene or a -(C(H)-COOH)- group or a -(C(H)-COO-)- group,

Cation(+) is a 1 ,1 ,3,3-tetramethylguanidinium cation or a lysinium cation or an argininium cation or a polylysinium cation or polycysteinium cation or polytyrosine.

or the cation is:

where

R¹ , R², R³ are independently a hydrogen atom, an ethylenoxy group (-CH₂CH₂0-), a polyethylenoxy group ((- CH₂CH₂0-)n, where n is a natural number 1 to 5), a C C^ alkyl group, a C C₁₀ alkoxy group, a C₃-C₁₂ cycloalkyl group, an -N(R’)(R”) amine group, substituted with hydrogen atoms, or may be substituted with at least one C_rC₁₂ alkyl group, C_rC₁₂ alkoxy, -N(R’)(R”) amine, -OR’ alkoxy group, where R, R’ and R” are the same or different C^C^ alkyl group, C₃-C₁₂ cycloalkyl group, C^C^ alkoxy group, with the proviso that at least one of R¹ , R², R³ is not a hydrogen atom.

2. A compound according to Claim 1 , wherein substituents R¹ and R² or R² and R³ or R¹ and R³ or R¹ , R2 and R³ of the ammonium cation are preferably connected, forming a chain or a ring system.

3. A compound according to Claim 1 or 2, where the ammonium cation is preferably a tertiary cation, or a secondary cation or a primary cation.

4. A compound according to Claim 1 or 2 or 3, wherein the anion of a partially fluorinated carboxylic acid is preferably selected from the following list, including anions 2a do 2s,

while the ammonium cation is selected from the list including cations 3a to 31,

3k

5. Use of a compound represented with formula 1

Cation (+) where:

C_XF_2X - is a straight chain, where X = 6 to 10;

C_yH_2y - is a straight chain, where Y = 1 to 2;

C_ZH_2Z - is a straight chain, where Z = 0 to 10;

G is a bond or a S atom or a carbonyloxy group (OCO), A is a bond or -OCO-C_zH_2z- where Z = 0 to 3 or -OCO-Ar-, where Ar is benzene or a -(C(H)-COOH)- group or a -(C(H)-COO-)- group,

Cation(+) is a 1 ,1 ,3,3-tetramethylguanidinium cation or a lysinium cation or an argininium cation or a polylysinium or a polycysteinium or a polytyros in ium cation or a potassium cation or a sodium cation. or Cation(+) is:

where

R¹ , R², R³ are independently a hydrogen atom, an ethylenoxy group (-CH₂CH20-), a polyethylenoxy group ((- CH₂CH₂0-)n, where n is a natural number 1 to 5), a C^C^ alkyl group, a C_rC₁₀ alkoxy group, a C₃-C₁₂ cycloalkyl group, an -N(R’)(R”) amine group, substituted with hydrogen atoms, or may be substituted with at least one C C₁₂ alkyl group, C C₁₂ alkoxy, -N(R’)(R”) amine, -OR’ alkoxy group, where R, R’ and R” are the same or different C^C^ alkyl group, C₃-C₁₂ cycloalkyl group, C^C^ alkoxy group, with the proviso that at least one of R¹ , R², R³ is not a hydrogen atom,

as a surfactant able to form water-in-oil and/or oil-in-water emulsions.

6. Use according to Claim 5, wherein substituents R¹ and R² or R² and R³ or R¹ and R³ or R¹ , R² and R³ of the ammonium cation are preferably connected, forming a chain or a ring system.

7. Use according to Claim 5, wherein the ammonium cation is preferably a tertiary, a secondary or a primary cation.

8. Use according to Claim 5, wherein the anion of a partially fluorinated carboxylic acid is preferably selected from the following list, including anions 2a do 2s,

2e

2f while the ammonium cation is selected from the list including cations 3a to 31,

3I

3k

9. Use of a compound represented with formula 1 as defined in Claim 5 in production of emulsions with high gas solubility, in particular solubility of oxygen and/or air.

10. Use of a compound represented with formula 1 as defined in Claim 5 in production of emulsions with emulsion particle sizes below 2 pm, preferably 1 ,5 pm, most preferably 1 pm.

1 1 . Use of a compound represented with formula 1 as defined in Claim 5 in storage of organs, tissues, biological material or long-term medical storage.

12. Use of a compound represented with formula 1 as defined in Claim 5 as a stabilising agent in blood substitute preparations.

13. Use of a compound represented with formula 1 as defined in Claim 5 in therapy of strokes and increasing the efficiency of photodynamic therapy of cancers.

14. Use of a compound represented with formula 1 as defined in Claim 5 as an ingredient of liquids enabling temporary support of respiration during artificial lung ventilation.

15. Use of a compound represented with formula 1 as defined in Claim 5 as an ingredient of liquids used in medical diagnostics, in particular in USG and MRI.

16. Use of a compound represented with formula 1 as defined in Claim 5 as a surfactant in compositions of medications, vaccines and medical products.

17. Use of a compound represented with formula 1 as defined in Claim 5 as an ingredient of cosmetic, dermatological and care products.

18. Use of a compound represented with formula 1 as defined in Claim 5 as an ingredient of washing, cleaning and disinfecting agents.

19. Use of a compound represented with formula 1 as defined in Claim 5 as an ingredient of paints, dyeing emulsions, varnishes and plastics.

20. Use of a compound represented with formula 1 as defined in Claim 5 as an ingredient of agrochemicals.

21 . Use of a compound represented with formula 1 as defined in Claim 5 as an ingredient of cooling mixtures in high end computers and servers.

22. Use of a compound represented with formula 1 as defined in Claim 5 as a component of culture medium delivering oxygen in bioreactors and other aerobic organism cultures.

23. Use of a compound represented with formula 1 as defined in Claim 5 as a component of culture medium delivering carbon dioxide in bioreactors and other anaerobic organism cultures.

24. Use of a compound represented with formula 1 as defined in Claim 5 in in vitro cultures of plant and animal cells.

25. A synthesis method of an ammonium salt of partially fluorinated organic acids, represented by the general formula 1

Cation (+)

where:

C_XF_2X - is a straight, where X = 6 to 10;

C_yH_2y - is a straight, where Y = 1 to 2;

C_ZH_2Z - is a straight, where Z = 0 to 10;

G is a bond or a S atom or a carbonyloxy group (OCO),

A is a bond or -OCO-C_zH_2z-, where Z = 0 to 3 or -OCO-Ar-, where Ar is benzene or a -(C(H)-COOH)- group or a -(C(H)-COO-)- group,

Cation(+) is a 1 ,1 ,3,3-tetramethylguanidinium cation or a lysinium cation or an argininium cation or a polylysinium cation or polycysteinium cation or polytyrosine.

or the cation is:

where

R¹, R², R³ are independently a hydrogen atom, an ethylenoxy group (-CH₂CH₂0-), a polyethylenoxy group ((- CH₂CH₂0-)n, where n is a natural number 1 to 5), alkyl group, a C_rC₁₀ alkoxy group, a

C₃-C₁₂ cycloalkyl group, an -N(R’)(R”) amine group, substituted with hydrogen atoms, or may be substituted with at least one C C₁₂ alkyl group, C C₁₂ alkoxy, -N(R’)(R”) amine, -OR’ alkoxy group, where R, R’ and R” are the same or different alkyl group, C₃-C₁₂ cycloalkyl group, alkoxy group, with the proviso that at least one of R¹, R², R³ is not a hydrogen atom;

characterised in that

the respective, partially fluorinated organic acid represented with the general formula 4

in which all the variables have the meanings specified above and n is 1 , is subjected to a reaction with the adequate amine or amino acid, resulting in formation of an ammonium salt of partially fluorinated organic acids, represented with the general formula 1.

26. A method according to claim 25, characterised in that the reaction is preferably performed in a solvent, an alcohol, preferably in methanol or in a mixture of alcohol, preferably methanol, with water.

27. A method according to claim 25 or 26, characterised in that the amine or amino acid is preferably added to the respective acid dissolved in alcohol, preferably in methanol, in the form or pure alcohol or of an aqueous solution.

28. A method according to claim 25 or 26 or 27, characterised in that the respective acid is used as an ester.

29. A method according to any of the Claims 25-25, characterised in that the reaction mixture is heated, preferably to its boiling point.