New Benzimidazole Pyridine Derivatives

The present invention relates to organic compounds useful for therapy and/or prophylaxis in a mammal, and in particular to compounds that modulate SIK activity.

The invention relates in particular to a compound of formula (I) wherein

R ¹ is hydrogen or halogen;

R ² and R ² ’ are independently selected from hydrogen, alkyl, cyclopropyl, haloalkyl and alkoxy alkyl;

Al is -O-, -NR ⁶ -, -(C=O)- or a bond;

R ⁶ is hydrogen or alkyl;

R ³ is hydroxyalkyl, heterocycloalkyl, heteroaryl, phenyl or cycloalkylalkyl, wherein heterocycloalkyl, heteroaryl, phenyl and cycloalkylalkyl are optionally substituted with 1, 2 or 3 substituents independently selected from R ⁷ ; if Al is -(C=O)-, then R ³ can also be haloalkylamino; each R ⁷ is independently selected from alkoxy, alkylamino, alkyl, aminocarbonyl, amino, cyano, cycloalkylamino, haloalkyl, halocycloalkyl, halogen, heteroaryl, hydroxycarbonylamino, alkoxyalkyl, alkylaminocarbonyl, alkylsulfonyl, alkoxycarbonimidoyl, aminocarbonyl, hydroxy, cycloalkylalkyl, haloalkoxy, heterocycloalkyl and cycloalkyl;

A2 is -O-, -NH- or a bond;

R ⁴ is hydrogen, alkyl, haloalkyl, alkoxyalkyl, dialkylaminoalkyl, cycloalkyl, cycloalkylcarbonyl, aryl, heteroaryl, heteroarylalkyl, heterocycloalkyl or heterocycloalkylalkyl; wherein aryl, cycloalkyl, heteroaryl, heteroarylalkyl, heterocycloalkyl and heterocycloalkylalkyl are optionally substituted with 1, 2 or 3 substituents independently selected from R ⁸ ; if A2 is a bond, then R ⁴ can also be halogen or cyano; each R ⁸ is independently selected from alkyl, halogen, cyano, alkylsulfonyl, alkylaminocarbonyl, heterocycloalkyl and alkoxyheterocycloalkylalkyl;

A3 is -O-, -NR ¹⁰ - or a bond;

R ⁵ is hydrogen, alkyl, alkylsulfonyl, cycloalkylcarbonyl, heterocycloalkylalkyl, heterocycloalkylalkylcarbonyl, aryl, heteroaryl or heterocycloalkyl, wherein cycloalkylcarbonyl, aryl, heteroaryl and heterocycloalkyl are optionally substituted with 1, 2 or 3 substituents independently selected from R ⁹ ; if A3 is a bond, then R ⁵ can also be halogen or cyano; each R ⁹ is independently selected from alkoxy, halogen, dialkylaminocarbonyl, alkyl, alkoxyalkoxy, alkoxyheterocycloalkylalkyl, alkoxyheterocycloalkylcarbonyl, haloalkyl, haloalkoxy, heterocycloalkylalkoxy, heterocycloalkyl, heterocycloalkyloxy, hydroxy, hydroxyalkyl, alkylheterocycloalkyl, (haloalkyl)cycloalkyl, alkylheterocycloalkylalkyl, heterocycloalkylalkyl, alkylsulfonyl, (alkyl)heterocycloalkyl, alkylheterocycloalkyloxy, heterocycloalkylheterocycloalkyl, heterocycloalkylheterocycloalkyl, CH3-O-(CH2-CH2-O) _n -, alkylaminocarbonyl and cyano; wherein n is selected from 5, 6, 7, 8 and 9; and

R ¹⁰ is hydrogen or alkyl carbonyl; or a pharmaceutically acceptable salt thereof.

Salt-inducible kinases (SIK) belong to a subfamily of AMP-activated protein kinases (AMPK) called AMPK -related kinases. There are three members, named SIK1, SIK2 and SIK3, that are broadly expressed. Their major biological role is to modify gene expression by controlling the phosphorylation and subcellular localization of two key classes of transcriptional regulatory factors: CRTCs (cAMP-regulated transcriptional coactivators) and class Ila HDACs (Histone deacetylases). Indeed, in basal state, both CRTCs and HDACs are phosphorylated by SIK kinases, and sequestered in the cytoplasm through interactions with their cytoplasmic chaperones 14-3-3. In response to extracellular cues that usually increase intracellular levels of cAMP, the SIK kinases’ activity is inhibited, CRTCs and HDACs are no longer phosphorylated and are hence released from 14-3-3. They can therefore translocate into the nucleus and regulate gene expression (reviewed in Wein et al., Trends Endocrinol Metab. 2018 Oct;29(10):723-735).

In macrophages, the inhibition of SIK kinases leads to 1) CRTC3 shuttling to the nucleus and increasing the transcription of IL- 10,; and 2) translocation of HD AC 4/5 to the nucleus and subsequent deacetylation of NF-KB resulting in decreased transcription of pro-inflammatory cytokines (Clark et al., Proc Natl Acad Sci U S A. 2012 Oct 16; 109(42): 16986-91.).

Macrophages are critical to maintaining tissue homeostasis, mediating inflammation, and promoting the resolution of inflammation. To achieve this diversity of function, macrophages have the ability to “polarize” differently in response to environment cues. The two extreme phenotypes along their activation state continuum are the “Ml” or “pro-inflammatory macrophages” and the “M2” or “pro-resolution macrophages”.

Strikingly, the inhibition of intracellular SIK kinases overrides these extracellular macrophage polarization signals and pushes them toward a pro-resolution phenotype. This comes with an increase in IL- 10 (by interfering with the SIK-CRTC3 pathway) and a concomitant decrease in TNF-a, IL- 12 and IL-6 (by interfering with the SIK-HDAC4/5 and NF- KB pathway). The high levels of IL- 10 and low levels of pro-inflammatory cytokines upon SIK inhibition will promote resolution of inflammation. The exploration of the SIK pathway has initially been described in macrophages (Clark et al., Proc Natl Acad Sci U S A. 2012 Oct 16;109(42):16986-91) and dendritic cells (Sundberg et al., Proc Natl Acad Sci U S A. 2014 Aug 26; 111(34): 12468-73) and the therapeutic potential of pan-SIK inhibitors has been confirmed in a mouse LPS (lipopolysaccharide) challenge model (Sundberg et al., ACS Chem Biol. 2016 Aug 19; 1 l(8):2105-l 1) and in colitis models (Fu et al., Inflamm Bowel Dis. 2021 Oct 20;27(l l): 1821 -1831). SIKs have since been shown to be important players in the functions of several immune cells, including mast cells (Darling et al., J Biol Chem. 2021 Jan-

Jun;296: 100428). Importantly, SIK1 is poorly expressed in macrophages and one embodiment of the invention are SIK2/3 inhibitors sparing SIK1, thus limiting potential SIK 1 -related toxicities.

SIK inhibitors have a high therapeutic potential in diseases that are 1) characterized by pro- inflammatory macrophage influx in the tissues and impaired tissue homeostasis and healing, or 2) where anti-TNF therapies are beneficial (partially or fully) or with insufficient levels of the IL10. Diseases with an inflammatory macrophage signature are e.g. rheumatoid arthritis, juvenile rheumatoid arthritis, NASH, primary sclerosing cholangitis, giant cell vasculitis and inflammatory bowel diseases (“IBD”), atherosclerosis, type 2 diabetes and glomerulonephritis.

Diseases with a proven link to IL-10 and TNF-a are IBD. Genetic alterations that reduce the function of IL- 10 (such as SNPs in IL- 10 or its receptor) are associated with an increased risk for IBD in humans. In addition, anti-TNF therapies are successful but only a subset of IBD patients are responsive and much of this limited responsiveness is lost over time. The described dual effect of SIK inhibitors (increased IL- 10 and decreased TNF-a) make them particularly pertinent for the treatment of IBD.

All three SIK kinase isoforms are expressed broadly in human tissues with the highest expression observed in skin and adipose tissues for SIK1, adipose tissue for SIK2 and testis and brain for SIK3. Similarly to their role in macrophages, SIKs in these cells phosphorylate CRTCs and class II HDCAs in response to extracellular signals, which subsequently change the expression of several cellular factors.

In addition to their physiological roles, reports have linked dysregulation of SIK expression to a few diseases. For example, SIK2 has been described as a risk locus for primary sclerosing cholangitis, a fibrotic disease regularly associated with IBD. In addition, SIK2 and SIK3 expression is higher in ovarian and prostate cancers and correlated with poor survival (Miranda et al., Cancer Cell. 2016 Aug 8;30(2):273-289; Bon et al., Mol Cancer Res. 2015 Apr; 13 (4): 620- 635).

As of today many diseases caused by dysregulation of the innate immune system lack efficient therapies and there is a high unmet medical need for new therapies. The present invention relates to a novel compounds that are highly active SIK inhibitors for the treatment of inflammatory, allergic and autoimmune diseases. In addition to inflammation, allergic and autoimmune diseases, SIK inhibitors can thus also be of potential relevance in cancer, metabolic diseases, bone density dysregulation diseases, pigmentation-related diseases or cosmetology, fibrotic diseases and depressive disorders.

In the present description the term “alkyl”, alone or in combination, signifies a straightchain or branched-chain alkyl group with 1 to 8 carbon atoms, particularly a straight or branched-chain alkyl group with 1 to 6 carbon atoms and more particularly a straight or branched-chain alkyl group with 1 to 4 carbon atoms. Examples of straight-chain and branched- chain C1-C8 alkyl groups include, but are not limited to, methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert.-butyl, the isomeric pentyls, the isomeric hexyls, the isomeric heptyls and the isomeric octyls, particularly methyl, ethyl, propyl, butyl and pentyl. Particular examples of alkyl are methyl, ethyl, propyl, isopropyl, butyl and isobutyl. Methyl, ethyl, propyl and butyl, like isobutyl, are further particular examples of “alkyl” in the compound of formula (I).

The term “cycloalkyl”, alone or in combination, signifies a cycloalkyl ring with 3 to 8 carbon atoms and particularly a cycloalkyl ring with 3 to 6 carbon atoms. Examples of cycloalkyl include, but are not limited to, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl and cyclooctyl. Particular examples of “cycloalkyl” are cyclopropyl and cyclobutyl.

The term “heterocycloalkyl”, alone or in combination, denotes a monovalent saturated or partly unsaturated mono- or bicyclic ring system of 4 to 12 ring atoms, comprising 1, 2, or 3 ring heteroatoms selected from N, O and S, the remaining ring atoms being carbon. Bicyclic means consisting of two cycles having one or two ring atoms in common. “Hetercycloylkyl” may comprise a carbonyl group, wherein the carbon is part of the ring system. The ring system can be attached to the remaining compound via an atom selected from C, N, S and O, in particular via a N atom (“N-heterocycloalkyl). Examples of “heterocycloalkyl” include, but are not limited to, morpholino, morpholin-4-yl, pyrrolidinyl, pyrrolidin-l-yl, pyrrolidin-3-yl, piperidinyl, 1- piperidyl, 4-piperidyl, 2-oxopyrrolidin-l-yl, piperazinyl, piperazin- 1-yl, azetidinyl, azetidin-l-yl, [3 -oxo-piperazin- 1-yl], (l,l-dioxo-l,2-thiazolidin-2-yl), (4,5,6,7-tetrahydropyrazolo[4,3- c]pyridin-l-yl), (3-oxo-l,5,6,8-tetrahydrooxazolo[3,4-a]pyrazin-7-yl), [rac-(3aR,6aS)- 2,3,3a,5,6,6a-hexahydro-lH-pyrrolo[3,2-b]pyrrol-4-yl], [rac-(3aS,6aR)-2,3,3a,5,6,6a-hexahydro- lH-pyrrolo[3,2-b]pyrrol-4-yl], (4-oxo-6,7-dihydro-5H-pyrazolo[l,5-a]pyrazin-3-yl), (6,7- dihydro-4H-pyrazolo[4,3-c]pyridin-l-yl), (4,7-diazaspiro[2.5]octan-7-yl), (2-oxa-5,8- diazaspiro[3.5]nonan-8-yl), 3-azabicyclo[3.2.0]heptan-3-yl), (5-azaspiro[2.4]heptan-5-yl), (2- azabicyclo[2.2.1]heptan-2-yl), 4-oxa-7-azaspiro[2.5]octan-7-yl, (3-azabicyclo[3.1.0]hexan-3-yl), (6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-l-yl), 2-oxa-7-azaspiro[3.4]octan-7-yl, (2-oxo-l- piperidyl), (2,3-dihydropyridazino[4,5-b][l,4]oxazin-8-yl), pyrrolidin-l-yl, 2-oxo-pyrimidin-4- yl, morpholinoethyl, 2-oxa-5-azaspiro[3.4]octan-5-yl, oxetan-3-yl, (2-oxo-l -piperidyl), 2-oxo-4- piperidyl, 5-oxo-pyrrolidin-3-yl, 2-oxa-5-azaspiro[3.4]octan-5-yl, (7,8-dihydro-5H-pyrano[4,3- c]pyridazin-3-yl), [rac-(4aS,7aR)-4-methyl-2,3,4a,5,7,7a-hexahydropyrrolo[3,4-b ][l,4]oxazin-6- yl], 6,7-dihydro-5H-cyclopenta[c]pyridazin-3-yl, 5,6-dihydropyrrolo[2,3-c]pyridazin-7-yl, 7-oxo- 5H-pyrrolo[3,4-b]pyri din-2 -yl, 5,6-dihydro-4H-pyrazolo[4,3-c]pyridin-l-yl, 6- azaspiro[3.4]octan-6-yl and [rac-(3aS,6aS)-6-oxo-2,3,3a,4,5,6a-hexahydropyrrolo[2,3-c]py rrol- 1-yl], Particular examples of “heterocycloalkyl” is pyrrolidin-l-yl and pyrrolidin-3-yl. In one particular embodiment, heterocycloalkyl is “N-heterocycloalkyl”.

The term “heteroaryl”, alone or in combination, signifies an aromatic mono- or bicyclic ring system with 5 to 12 ring atoms, comprising 1, 2, 3 or 4 heteroatoms each independently selected from N, O and S, the remaining ring atoms being carbon. The ring system can be attached to the remaining compound via an atom selected from C, N, S and O, in particular via a N atom (“N-heteroaryl). Examples of heteroaryl include, but are not limited to, pyrazolyl, pyrazol-l-yl, pyrazol-3-yl, pyrazol-4-yl, pyridinyl, 2-pyridyl, 3 -pyridyl, 4-pyridyl, pyridazinyl, pyridazin-3-yl, pyridazin-4-yl, pyrazinyl, pyrazin-2-yl, isoxazolyl, isoxazol-3-yl, isoxazol-4-yl, oxazolyl, 2-oxazol-5-yl, 2-oxo-3-imidazol-l-yl, pyrimidinyl, pyrimidin-5-yl, benzotriazolyl, 1H- benzotriazol-4-yl, furanyl, furyl, 2-furyl, 3-furyl, [6-oxo-lH-pyridazin-5-yl], triazolyl, triazol-1- yl, triazol-2-yl, triazol-3-yl, 2-oxo-4-pyridyl. pyrimidin-2-yl, pyrimidin-5-yl, (l,3,4-oxadiazol-2- yl), (l,3,4-thiadiazol-2-yl), (l,2,4-triazin-3-yl), 2-oxo-pyrimidin-4-yl, ( 1 -m ethyl -2-oxo-3 -pyridyl) and (2,3-dihydropyridazino[4,5-b][l,4]oxazin-8-yl). Particular examples of “heteroaryl” are pyrazol-l-yl, pyrazol-4-yl, pyridazin-3-yl ane pyrimidin-5-yl. In one particular embodiment, heteroaryl is “N-heteroaryl”.

The term “aryl” denotes a monovalent aromatic carbocyclic mono- or bicyclic ring system comprising 6 to 10 carbon ring atoms. Examples of aryl moieties include phenyl and naphthyl. A particular examples of aryl is phenyl.

The term “alkoxy” or “alkyloxy”, alone or in combination, signifies a group of the formula alkyl-O- in which the term "alkyl" has the previously given significance, such as methoxy, ethoxy, n-propoxy, isopropoxy, n-butoxy, isobutoxy, sec-butoxy and tert.-butoxy. Particular examples of “alkoxy” are methoxy and ethoxy.

The term “oxy”, alone or in combination, signifies the -O- group.

The term “oxo”, alone or in combination, signifies the =0 group.

The terms “halogen” or “halo”, alone or in combination, signifies fluorine, chlorine, bromine or iodine and particularly fluorine, chlorine or bromine, more particularly fluorine. The term “halo”, in combination with another group, denotes the substitution of said group with at least one halogen, particularly substituted with one to five halogens, particularly one to four halogens, i.e. one, two, three or four halogens.

The term “haloalkyl”, alone or in combination, denotes an alkyl group substituted with at least one halogen, particularly substituted with one to five halogens, particularly one to three halogens, more particularly two to three halogens. Particular “haloalkyl” are fluoromethyl, fluoroethyl, fluoropropyl, fluorobutyl, difluoromethyl, difluoroethyl, trifluoromethyl and trifluoroethyl.

The term “haloalkoxy”, alone or in combination, denotes an alkoxy group substituted with at least one halogen, particularly substituted with one to five halogens, particularly one to three halogens. Particular “haloalkoxy” are fluoromethoxy, fluoroethoxy and fluoropropyloxy.

The terms “hydroxyl” and “hydroxy”, alone or in combination, signify the -OH group.

The term “carbonyl”, alone or in combination, signifies the -C(O)- group.

The term “amino”, alone or in combination, signifies the primary amino group (-NH2), the secondary amino group (-NH-), or the tertiary amino group (-N-).

The term “alkylamino” is alkyl group linked to a -NH- group. The term “dialkylamino” denotes two alkyl groups linked to a -N- atom.

The term “sulfonyl”, alone or in combination, signifies the -SO2- group.

The term “pharmaceutically acceptable salts” refers to those salts which retain the biological effectiveness and properties of the free bases or free acids, which are not biologically or otherwise undesirable. The salts are formed with inorganic acids such as hydrochloric acid, hydrobromic acid, sulfuric acid, nitric acid, phosphoric acid, particularly hydrochloric acid, and organic acids such as formic acid, acetic acid, propionic acid, glycolic acid, pyruvic acid, oxalic acid, maleic acid, malonic acid, succinic acid, fumaric acid, tartaric acid, citric acid, benzoic acid, cinnamic acid, mandelic acid, methanesulfonic acid, ethanesulfonic acid, p-toluenesulfonic acid, salicylic acid, N-acetylcystein. In addition these salts may be prepared from addition of an inorganic base or an organic base to the free acid. Salts derived from an inorganic base include, but are not limited to, the sodium, potassium, lithium, ammonium, calcium, magnesium salts. Salts derived from organic bases include, but are not limited to salts of primary, secondary, and tertiary amines, substituted amines including naturally occurring substituted amines, cyclic amines and basic ion exchange resins, such as isopropylamine, trimethylamine, diethylamine, triethylamine, tripropylamine, ethanolamine, lysine, arginine, N-ethylpiperidine, piperidine, polyamine resins. The compound of formula (I) can also be present in the form of zwitterions. Particular pharmaceutically acceptable salts of compounds of formula (I) are the salts of trifluoroacetic acid, formic acid, hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid and methanesulfonic acid.

Tautomeric forms, i.e. structural isomers which interconvert with the compound of formula (I), in particular in solution, exist.

For instance, the compound of formula (I) wherein A3 is -NH- and R5 is pyridazin-3-yl, is in tautomeric equilibrium with its tautomeric form (I’):

Other tautomeric forms of the compound of formula (I) may also exist.

The compound of formula (I) can be represented by different mesomeric structures such as for instance: If one of the starting materials or compounds of formula (I) contain one or more functional groups which are not stable or are reactive under the reaction conditions of one or more reaction steps, appropriate protecting groups (as described e.g. in “Protective Groups in Organic Chemistry” by T. W. Greene and P. G. M. Wuts, 3 ^rd Ed., 1999, Wiley, New York) can be introduced before the critical step applying methods well known in the art. Such protecting groups can be removed at a later stage of the synthesis using standard methods described in the literature. Examples of protecting groups are tert-butoxycarbonyl (Boc), 9-fluorenylmethyl carbamate (Fmoc), 2-trimethylsilylethyl carbamate (Teoc), carbobenzyl oxy (Cbz) and p- methoxybenzyloxycarbonyl (Moz).

The compound of formula (I) can contain several asymmetric centers and can be present in the form of optically pure enantiomers, mixtures of enantiomers such as, for example, racemates, mixtures of diastereoisomers, diastereoisomeric racemates or mixtures of diastereoisomeric racemates.

The term “asymmetric carbon atom” means a carbon atom with four different substituents. According to the Cahn-Ingold-Prelog Convention an asymmetric carbon atom can be of the “R” or “S” configuration.

Furthermore, the invention includes all optical isomers, i.e. diastereoisomers, diastereomeric mixtures, racemic mixtures, all their corresponding enantiomers and/or tautomers as well as their solvates, wherever applicable, of the compound of formula (I).

If desired, racemic mixtures of the compound of the invention may be separated so that the individual enantiomers are isolated. The separation can be carried out by methods well known in the art, such as the coupling of a racemic mixture of compounds to an enantiomerically pure compound to form a diastereomeric mixture, followed by separation of the individual diastereomers by standard methods, such as fractional crystallization or chromatography.

In the embodiments, where an optically pure enantiomer is provided, optically pure enantiomer means that the compound contains > 90 % of the desired isomer by weight, particularly > 95 % of the desired isomer by weight, or more particularly > 99 % of the desired isomer by weight, said weight percent based upon the total weight of the isomer of the compound. A chirally pure or chirally enriched compound may be prepared by chirally selective synthesis or by separation of enantiomers. The separation of enantiomers may be carried out on the final product or alternatively on a suitable intermediate. Furthermore, the invention includes all substituents in their corresponding deuterated form, wherever applicable, of the compound of formula (I).

Furthermore, the invention includes all substituents in their corresponding tritiated form, wherever applicable, of the compound of formula (I).

A certain embodiment of the invention relates to the compound of formula (I) as described herein, or a pharmaceutically acceptable salt thereof, wherein at least one substituent comprises at least one radioisotope. Particular examples of radioisotopes are 2H, 3H, 13C, 14C and 18F.

General Synthetic Schemes

The synthesis of the compound of formula (I) can, for example, be accomplished according to the non-exhaustive procedures described below in general schemes 1-11. In some instances, the sequence of the reaction steps can be altered and the individual steps of the different schemes can be combined in different ways as disclosed herein and according to common general knowledge. In general, the reaction conditions provided below and the reaction conditions can in some instances be further modified according to the procedures described herein and according to common general knowledge.

Scheme 1

In scheme 1, the synthesis of a compound of formula (I-a) is described. The compound of formula (I-a) is a compound of formula (I), wherein each of Al is a bond; A2 is -O-; A3 is -O-; R ¹ is hydrogen; R ² and R ² ’ are both hydrogen; R ³ is phenyl optionally substituted with one, two or three substituents independently selected from R ⁷ ; R ⁴ is alky; R ⁵ is alky; each R ⁷ is indepently selected from alkoxy and halogen.

Step A: Methyl 2,6-dichloronicotinate 1 can be reacted with a 5,6-disubstituted benzimidazole 2 in the presence of a strong base such as for instance NaH in a polar solvent such as DMF or DMSO at about 0 °C to yield intermediate 3. - Il ¬

Step B: Intermediate 3 can undergo a palladium-catalyzed cross-coupling reaction (Suzuki- Miyaura) with a suitable reactant such as for instance the corresponding aryl boronic acid or aryl pinacol borane, catalytic Pd(PPhs)4 or other suitable Pd catalysts in presence of a suitable base such as for instance ISfeCCh, and in a suitable solvent such as for instance DME while heating (e.g. MW microwave at 120 °C) to yield intermediate 4.

Step C: The ester of 4 can be reduced to the corresponding alcohol using a suitable reducing agent such as for instance Li AIH4 in a suitable solvent such as for instance THF at 0 °C to yield the compound of formula (I-a).

Scheme 2 in scheme 2, the synthesis of a racemic compound of formula (I-b), as well as the corresponding entantiomers (Compounds I-b’ and I-b”) is described. The compound of formula (I-b) is a compound of formula (I), wherein each of Al is a bond; A2 is -O-; A3 is -O-; R ¹ is hydrogen; R ² is alkyl; R ² ’ is hydrogen; R ³ is phenyl optionally substituted with one, two or three substituents independently selected from R ⁷ ; R ⁴ is alky; R ⁵ is alky; each R ⁷ is indepently selected from alkoxy and halogen.

Step A: In the presence of a suitable oxidation reagent such as for instance DMP (Dess- Martin periodinane) in a suitable solvent such as for instance DCM, the alcohol group of Compound (I-a) in Scheme 1 can be oxidized to the corresponding aldehyde 5 at ambient temperature.

Step B: The aldehyde 5 can be reacted with a suitable alkyl magnesium halide (such as for instance MeMgBr or EtMgBr or cyclopropylMgBr) at -30 °C to 0 °C in a suitable solvent such as for instance a mixture of THF/2-MeTHF to yield the corresponding secondary alcohol I-b.

Step C: The racemic mixture of the secondary alcohol I-b can be separated by chiral SFC into the enantiomers I-b’ and I-b”. Scheme 3

In scheme 3, the synthesis of a compound of formula (I-c) is described. The compound of formula (I-c) is a compound of formula (I), wherein each of Al is a bond; A2 is -O-; A3 is -O-; R ¹ is hydrogen; R ² is hydrogen; R ² ’ is hydrogen; R ³ is N-heterocycloalkyl; R ⁴ is alky; R ⁵ is alky.

Step A: Intermediate 3 from Scheme 1 can be substituted with a saturated N-heterocycle 6 in the presence of a strong base (such as for instance NaH, or CS2CO3 or other carbonates) in a polar solvent (such as for instance DMF, DMA, NMP or DMSO) to yield intermediate 7.

Step B: The ester of the intermediate 7 can be reduced in the presence of a reducing agent, such as for instance Li AIH4, to the a compound of formula (I-c), in a similar manner than shown step C in scheme 1.

Scheme 4

In scheme 4, the synthesis of a compound of formula (I-d) and a compound of formula (I- e) is described. The compound of formula (I-d) is a compound of formula (I), wherein Al is a bond; A2 is -O-; A3 is -O-; R ¹ is hydrogen; R ² is hydrogen; R ² ’ is hydrogen; R ³ is N- heterocycloalkyl; R4 is alkyl; R5 is alkyl. The compound of formula (I-e) is a compound of formula (I), wherein Al is -NH-; A2 is -O-; A3 is -O-; R ¹ is hydrogen; R ² is hydrogen; R ² ’ is hydrogen; R ³ is hydroxyalkyl; R ⁴ is alkyl; R ⁵ is alkyl.

Step A: Methyl 2,6-dichloronicotinate 1 can be reacted with a cyclic amide 8 in the presence of a suitable base such as for instance NaH in a suitable solvent such as DMF at -10 °C - 0 °C to yield intermediate 9. Step B: Further substitution of intermediate 9 with a 5,6-disubstituted benzimidazole in the presence of a strong base such for instance NaH in a polar solvent (such as for instance DMF, DMA, NMP or DMSO) at 0 °C yields intermediate 11.

Step C: The ester of intermediate 11 can be reduced in the presence of a suitable reducing agent such as for instance LiAIF to yield the compound of formula (I-d), in a similar manner than in step C in scheme 1. The open chain compound (I-e) can also be obtained via the reduction step.

Scheme 5

In scheme 5, the synthesis of a racemic compound of formula (I-f), as well as the corresponding entantiomers (Compounds I-f and I-f ’) is described. The compound of formula (I-f) is a compound of formula (I), wherein each of Al is a bond; A2 is -O-; A3 is -O-; R ¹ is hydrogen; R ² is alkyl; R ² ’ is hydrogen; R ³ is phenyl or heteroaryl, wherein phenyl and heteroaryl are optionally substituted with one, two or three substituents independently selected from R7; R4 is alky; R ⁵ is alky; each R ⁷ is indepently selected from aminocarbonyl, methyl and cyano.

Step A: Intermediate 12 can be obtained from Intermediate 3 from Scheme 1 through a sequence of (1) reduction with a suitable reducing agent such as for instance LiAlH4 in a suitable solvent such as for instance THF at 0 °C, (2) oxidation with suitable reagent such as for instance DMP at room temperature to yield an aldehyde, (3) reaction with a suitable alkyl magnesium halide (such as for instance MeMgBr or EtMgBr or cyclopropylMgBr) in THF at -20 °C - 0 °C, and finally protection of the corresponding secondary alcohol with TBDMSC1 in DCM in the presence of imidazole.

Step B: A Palladium-catalyzed cross-coupling reaction ( Suzuki -Miy aura) with the corresponding aryl boronic acid or aryl pinacol borane, catalytic Pd(PPhs)4 or othe suitable Pd catalysts and a suitable base (K3PO4, CS2CO3, K2CO3, ISfeCCh) in a suitable solvent (DME) while heating (e.g. MW at 80 °C - 120 °C) yields a compound of formula (I-f).

Step C: The racemic mixture of the secondary alcohol I-f can be further separated by chiral

SFC into the enantiomers I-f and I-f ’.

Scheme 6

In scheme 6, the synthesis of a racemic compound of formula (I-g), as well as the corresponding entantiomers (Compounds I-g’ and I-g”) is described. In scheme 6, the synthesis of a racemic compound of formula (I-h), as well as the corresponding entantiomers (Compounds I-h’ and I-h”) is also described. The compound of formula (I-g) is a compound of formula (I), wherein Al is a bond; A2 is a bond; A3 is -NH-: R ¹ is hydrogen; R ² is alkyl; R ² ’ is hydrogen; R ³ is pyrazol-l-yl optionally substituted with one, two or three substituents independently selected from R ⁷ ; R ⁴ is hydrogen; R ⁵ is pyridazin-3-yl optionally substituted with R ⁹ ; each R ⁷ is independently selected from alkyl, cyano, haloalkyl, alkoxy, alkylaminocarbonyl and alkyl sulfonyl; R ⁹ is alkyl. The compound of formula (I-h) is a compound of formula (I), wherein Al is a bond; A2 is a -NH-; A3 is a bond: R ¹ is hydrogen; R ² is alkyl; R ² ’ is hydrogen; R ³ is pyrazol-l-yl optionally substituted with one, two or three substituents independently selected from R ⁷ ; R ⁴ is pyridazin-3-yl optionally substituted with R ⁸ ; R ⁵ is hydrogen; each R ⁷ is independently selected from alkyl, cyano, haloalkyl, alkoxy, alkylaminocarbonyl and alkylsulfonyl; R ⁸ is alkyl.

Step A: l-(6-chloro-2-fluoro-3-pyridyl)alkanone 13 can be reacted with a substituted pyrazole 14 in the presence of a suitable organic or mineral base, such as for instance DIPEA, DBU, K2CO3, CS2CO3 or NaH, in a suitable polar solvent (for instance DMF, DMA, NMP, DMSO or THF, MeTHF) to yield intermediate 15.

Step B: Intermediate 18 can be obtained from the reaction of 5-aminobenzimidazole 16 and (6-alkylpyridazin-3-yl)amine 17 in iPrOH while heating to reflux. Step C: The intermediates 15 and 18 can be combined in the presence of a suitable organic or mineral base (such as for instance DIPEA, DBU, K2CO3, CS2CO3 or NaH) in a suitable polar solvent (such as for instance DMF, DMA, NMP, DMSO or THF, MeTHF) to yield the regioisomeric intermediates 19 and 20 which can be separated by flash column chromatography.

Step D: The corresponding secondary alcohols (I-g and I-h) can be obtained after reduction of the carbonyl group with a suitable reducing agent such as for instance NaBEU or NaCNBEE (1-5 equiv.) in a suitable solvent such as for instance MeOH (and in some cases a second co-solvent, e.g. DCM, THF, DMF) at temperatures between -40 °C and rt.

Step E: The racemic mixture of the secondary alcohol I-g can be further separated by chiral SFC into the enantiomers I-g’ and I-g”. Similarly, the racemic mixture of the secondary alcohol I-h can be further separated by chiral SFC into the enantiomers I-h’ and I-h”.

Scheme 7

In scheme 7, the synthesis of a compound of formula (I-i) and a compound of formula (I-j) is described. The compound of formula (I-i) is a compound of formula (I), wherein Al is a bond; A2 is a bond; A3 is -NH-: R ¹ is hydrogen; R ² is alkyl; R ² ’ is hydrogen; R ³ is pyrazol-l-yl optionally substituted with one, two or three substituents independently selected from R ⁷ ; R ⁴ is hydrogen; R ⁵ is alkyl, heterocycloalkyl or heteroaryl, wherein heterocycloalkyl and heteroaryl are optionally substituted with one, two or three substituents independently selected from R ⁹ ; each R ⁷ is independently selected from alkyl, cyano, haloalkyl, alkoxy, alkylaminocarbonyl and alkyl sulfonyl; R ⁹ is alkyl, cyano or alkoxy. The compound of formula (I-j) is a compound of formula (I), wherein Al is a bond; A2 is -NH-; A3 is a bond: R ¹ is hydrogen; R ² is alkyl; R ² ’ is hydrogen; R ³ is pyrazol-l-yl optionally substituted with one, two or three substituents independently selected from R ⁷ ; R ⁴ is alkyl, heterocycloalkyl or heteroaryl, wherein heterocycloalkyl and heteroaryl are optionally substituted with one, two or three substituents independently selected from R ⁸ ; R ⁵ is hydrogen; each R ⁷ is independently selected from alkyl, cyano, haloalkyl, alkoxy, alkylaminocarbonyl and alkylsulfonyl; R ⁸ is alkyl, cyano or alkoxy.

Step A: The regioi someric intermediates 22 and 23 can be obtained - similarly to the description of step C in scheme 6 - using intermediate 15 and 5-bromobenzimidazole 21 as the second reagent.

Step B: Introduction of the R7- substituted amine can be performed via a Buchwald- Hartwig coupling using a suitable base such as for instance CS2CO3 K2CO3 or K3PO4, and as suitable palladium catalyst such as for instance t-Buxphos-Pd-G3 or [tBuBrettPhos Pd(allyl)]OTf at between around 80°C to around 90 °C to yield intermediates 24 and 25, respectively .

Step C: The corresponding secondary alcohols can be obtained after reduction of the carbonyl of intermediates 24 and 25 with a suitable reducing agent such as for instance NaBFU (1-5 equiv.) in a suitable solvent such as for instance MeOH (and in some cases a second cosolvent, e.g. DCM, THF or DMF) at temperatures between -40 °C and rt to yield a compound of formula (I-i) and a compound of formula (I-j), respectively. The enantiomers of the secondary alcohol can be further separated by chiral SFC.

Scheme 8

In scheme 8, the synthesis of a compound of formula (I-k) and a compound of formula (1-1) is described. The compound of formula (I-k) is a compound of formula (I), wherein Al is a bond; A2 is a bond; A3 is -NH-: R ¹ is hydrogen; R ² is alkyl; R ² ’ is hydrogen; R ³ is pyrazol-l-yl optionally substituted with one, two or three substituents independently selected from R ⁷ ; R ⁴ is hydrogen; R ⁵ heteroaryl optionally substituted with one, two or three substituents independently selected from R ⁹ ; each R ⁷ is independently selected from alkyl, cyano, haloalkyl, alkoxy, alkylaminocarbonyl and alkylsulfonyl; R ⁹ is alkyl, cyano or alkoxy. The compound of formula (I-j) is a compound of formula (I), wherein Al is a bond; A2 is -NH-; A3 is a bond: R ¹ is hydrogen; R ² is alkyl; R ² ’ is hydrogen; R ³ is pyrazol-l-yl optionally substituted with one, two or three substituents independently selected from R ⁷ ; R ⁴ is heteroaryl optionally substituted with one, two or three substituents independently selected from R ⁸ ; R ⁵ is hydrogen; each R ⁷ is independently selected from alkyl, cyano, haloalkyl, alkoxy, alkylaminocarbonyl and alkyl sulfonyl; R ⁸ is alkyl, cyano or alkoxy.

Step A: The carbonyl group of the regioisomer intermediates 22 and 23 obtained in step A of scheme 7 can be reduced with a suitable reducing agent such as for instance NaBT or NaCNBHs in a suitable solvent such as for instance MeOH/THF (1 :1) at around 0 °C, to yield intermediates 26 and 27 respectively.

Step B: An arylamine group can be introduced via a Buchwald-Hartwig coupling using for instance CS2CO3 as a base and RuPhos-Pd-G3 as catalyst in a suitable solvent such as for instance 1,4-di oxane at 100 °C, to yield a compound of formula (I-k) and a compound of formula (1-1) respectively.

Scheme 9

In scheme 9, the synthesis of a compound of formula (I-m) is described. The compound of formula (I-m) is a compound of formula (I), wherein Al is a bond; A2 is a bond; A3 is -NH-: R ¹ is hydrogen; R ² is methyl; R ² ’ is hydrogen; R ³ is N-heteroaryl optionally substituted with one, two or three substituents independently selected from R ⁷ ; R ⁴ is hydrogen; R ⁵ is pyridazin-3-yl substituted with methyl; each R ⁷ is independently selected from alkyl, cyano, halogen, haloalkyl, haloalkoxy, hydroxy, alkoxy, and cycloalkylamino.

Step A: l-(2-chloro-6-fluoro-3-pyridyl)ethanone 30 can be obtained from the reaction of 3- bromo-2-chloro-6-fluoro-pyridine 28 and tributyl(l-ethoxyvinyl)tin 29 in the presence of a suitable catalyst such as for instance Pd(PPh3)C12 and a suitable base such as for instance K2CO3, CS2CO3 or K3PO4 in a suitable solvent such as for instance 1,4-di oxane and H2O at around 100 °C.

Step B: The intermediate 30 can then be reacted with N-(6-methylpyridazin-3-yl)-lH- benzimidazol-5-amine (intermediate 18 from Scheme 6) in DMSO at 60 °C to obtain intermediate 31 (and its regioisomer).

Step C: A palladium-catalyzed cross-coupling reaction ( Suzuki -Miy aura) with the corresponding aryl boronic acid or aryl pinacol borane, a suitable catalyst such as for instance PdC12(dppf) CH2C12 and a suitable base (for instance ISfeCCh) in a solvent such as for instance 1,4-di oxane while heating to around 100 °C, yields intermediate 32.

Step D: The compound I-m can be obtained after reduction of the carbonyl group of 32 with a suitable reducing agent such as for instance NaBTU or NaCNBHs (1-5 equiv.) in a suitable solvent such as for instance MeOH (and in some cases a second co-solvent, e.g. DCM, THF or DMF) at temperatures between around -40 °C and rt.

Scheme 10

In scheme 10, the synthesis of a compound of formula (I-n) is described. The compound of formula (I-n) is a compound of formula (I), wherein Al is a bond; A2 is a bond; A3 is -NH-; R ¹ is hydrogen; R ² is methyl; R ² ’ is hydrogen; R ³ is cycloalkyl optionally substituted with one, two or three substituents independently selected from R ⁷ ; R ⁴ is hydrogen; R ⁵ is pyridazin-3-yl substituted with methyl; each R ⁷ is independently selected from alkyl, cyano, halogen, haloalkyl, haloalkoxy, hydroxy, alkoxy, and cycloalkylamino.

Step A . l-(6-chloro-2-fluoro-3-pyridyl)ethanone 33 can be eacted with a cyclic amine (or sulfonamide or amide) in the presence of a suitable base such as for instance K2CO3 or CS2CO3 in a suitable solvent such as e.g. DMSO to yield intermediate 34.

Step B: Intermediate 34 can be reacted in DMSO with N-(6-methylpyridazin-3-yl)-lH- benzimidazol-5-amine (intermediate 18 from Scheme 6) in the presence of K2CO3 or CS2CO3 at 30 °C - 50 °C to obtain intermediate 35 (and its regioisomer).

Step C: The secondary alcohols of compound of formula (I-n) can be obtained after reduction of the carbonyl of intermediate 35 with a suitable reducing agent such as for instance NaBH4 (1-5 equiv.) in a suitable solvent such as for instance MeOH (and in some cases a second co-solvent, e.g. DCM, THF, DMF) at temperatures between around -40 °C and rt. Step D: The enantiomers I-n’ and I-n” of the secondary alcohol can be separated by chiral

SFC.

Scheme 11

In scheme 11, the synthesis of a compound of formula (I-o) is described. The compound of formula (I-o) is a compound of formula (I), wherein Al is -NH-; A2 is a bond; A3 is -NH-: R ¹ is hydrogen; R ² is methyl; R ² ’ is hydrogen; R ³ is alkyl; R ⁴ is hydrogen; R ⁵ is pyridazin-3-yl substituted with methyl; each R ⁷ is independently selected from alkyl, cyano, halogen, haloalkyl, haloalkoxy, hydroxy, alkoxy, and cycloalkylamino.

Step A : l-(6-chloro-2-fluoro-3-pyridyl)ethanone 33 can be reacted with an aliphatic amine in the presence of DIPEA in DMSO or DMF or DME or NMP to yield intermediate 36.

Step B Intermediate 36 can be reacted in DMSO with N-(6-methylpyridazin-3-yl)-lH- benzimidazol-5-amine (intermediate 18 from Scheme 6) in the presence of K2CO3 at 30 °C to obtain intermediate 37 (and its regioisomer).

Step C: The compound of formula (I-o) can be obtained after reduction of the carbonyl with a suitable reducing agent such as for instance NaBEU (1-5 equiv.) in a suitable solvent such as for instance MeOH (and in some cases a second co-solvent, e.g. DCM, THF, DMF) at temperatures between around -40 °C and rt.

The invention thus also relates to a process for the preparation of a compound according to the invention, comprising one of the following steps:

(a) the reaction of a compound of formula (Bl) with a reducing agent;

(b) the reaction of a compound of formula (Cl) with a reducing agent; or

(c) the reaction of a compound (DI) with a compound of formula R ^c MgX, wherein Al, A2, A3, R ¹ , R ² , R ³ , R ⁴ and R ⁵ are as defined above, R ^a is alkyl or cycloalkyl, R ^b is hydrogen or alkyl, R ^c is alkyl or cycloalkyl, and X is halogen.

The reducing agent of step (a) can be LiAlTU, DIBAL-H,

The solvent of step (a) can advantageously be THF.

Convenient conditions for step (a) are between around -60 °C to around 40 °C, in particular between around -50 °C to around 30 °C, more particular between around -40°C to around 20 °C during 1-24 hrs, advantageously during 1-12 hrs.

The reducing agent of step (b) can be for instance NaBTU.

The solvent of step (b) can be for instance methanol or a mixture of methanol and THF.

Convenient conditions for step (b) are between around -60 °C to around 40 °C, in particular between around -50 °C to around 30 °C, more particular between around -40°C to around 20 °C during 1-24 hrs, advantageously during 1-12 hrs.

In step (c) the solvent can be for instance THF, 2-MeTHF or a mixture thereof.

Convenient conditions for step (c) are between around -80 °C to around 30 °C, in particular between around -78 °C to around 20 °C, more particular between around -40 °C to around 0 °C during 1-24 hrs, advantageously during 1-12 hrs.

Conveniently, X is chloride, bromide or iodide. Advantageously, X is bromide.

The invention also relates to a compound according to the invention when manufactured according to a process of the invention.

Pharmaceutical Compositions

Another embodiment of the invention provides a pharmaceutical composition or medicament containing a compound of the invention and a therapeutically inert carrier, diluent or excipient, as well as a method of using the compounds of the invention to prepare such composition and medicament. In one example, the compound of formula (I) may be formulated by mixing at ambient temperature at the appropriate pH, and at the desired degree of purity, with physiologically acceptable carriers, i.e., carriers that are non-toxic to recipients at the dosages and concentrations employed into a galenical administration form. The pH of the formulation depends mainly on the particular use and the concentration of compound, but preferably ranges anywhere from about 3 to about 8. In one example, a compound of formula (I) is formulated in an acetate buffer, at pH 5. In another embodiment, the compound of formula (I) is sterile. The compound may be stored, for example, as a solid or amorphous composition, as a lyophilized formulation or as an aqueous solution.

Compositions are formulated, dosed, and administered in a fashion consistent with good medical practice. Factors for consideration in this context include the particular disorder being treated, the particular mammal being treated, the clinical condition of the individual patient, the cause of the disorder, the site of delivery of the agent, the method of administration, the scheduling of administration, and other factors known to medical practitioners.

The compounds of the invention may be administered by any suitable means, including oral, topical (including buccal and sublingual), rectal, vaginal, transdermal, parenteral, subcutaneous, intraperitoneal, intrapulmonary, intradermal, intrathecal, epidural and intranasal, and if desired for local treatment, intralesional administration. Parenteral infusions include intramuscular, intravenous, intraarterial, intraperitoneal, or subcutaneous administration.

The compounds of the present invention may be administered in any convenient administrative form, e.g., tablets, powders, capsules, solutions, dispersions, suspensions, syrups, sprays, suppositories, gels, emulsions, patches, etc. Such compositions may contain components conventional in pharmaceutical preparations, e.g., diluents, carriers, pH modifiers, sweeteners, bulking agents, and further active agents.

A typical formulation is prepared by mixing a compound of the present invention and a carrier or excipient. Suitable carriers and excipients are well known to those skilled in the art and are described in detail in, e.g., Ansel, Howard C., et al., Ansel’s Pharmaceutical Dosage Forms and Drug Delivery Systems. Philadelphia: Lippincott, Williams & Wilkins, 2004; Gennaro, Alfonso R., et al. Remington: The Science and Practice of Pharmacy. Philadelphia: Lippincott, Williams & Wilkins, 2000; and Rowe, Raymond C. Handbook of Pharmaceutical Excipients. Chicago, Pharmaceutical Press, 2005. The formulations may also include one or more buffers, stabilizing agents, surfactants, wetting agents, lubricating agents, emulsifiers, suspending agents, preservatives, antioxidants, opaquing agents, glidants, processing aids, colorants, sweeteners, perfuming agents, flavoring agents, diluents and other known additives to provide an elegant presentation of the drug (i.e., a compound of the present invention or pharmaceutical composition thereof) or aid in the manufacturing of the pharmaceutical product (i.e., medicament).

Example A Film coated tablets containing the following ingredients can be manufactured in a conventional manner: The active ingredient is sieved and mixed with microcrystalline cellulose and the mixture is granulated with a solution of polyvinylpyrrolidone in water. The granulate is then mixed with sodium starch glycolate and magnesium stearate and compressed to yield kernels of 120 or 350 mg respectively. The kernels are lacquered with an aq. solution / suspension of the above mentioned film coat.

Example B

Capsules containing the following ingredients can be manufactured in a conventional manner:

The components are sieved and mixed and filled into capsules of size 2.

Example C

Injection solutions can have the following composition: The active ingredient is dissolved in a mixture of Polyethylene glycol 400 and water for injection (part). The pH is adjusted to 5.0 by addition of acetic acid. The volume is adjusted to 1.0 ml by addition of the residual amount of water. The solution is filtered, filled into vials using an appropriate overage and sterilized.

Experimental Procedures

Abbreviations

[tBuBrettPhos Pd(allyl)]OTf allyl (2 -di -tert-butylphosphino-3,6-dimethoxy-2’, 4 ’,6’ -triisopropyl - l,l’-biphenyl)palladium(II) triflate (CAS # 1798782-15-6)

2-MeTHF 2-methyl tetrahydrofuran

ATP adenosine triphosphate aq. aqueous

Boe tert-butyloxycarbonyl

CDI carbonyldiimidazole

D ABCO 1 , 8 -diazabicyclo [5.4.0] undec-7 -ene

DAST diethylaminosulfur trifluoride dba dibenzylideneacetone

DCM dichloromethane

DIAD diisopropyl azodicarboxylate

DIBAL-H diisobutylaluminium hydride

DIPEA A'.A'-diisopropylcthylaminc

DMF NJ -dimethylformamide

DMSO dimethyl sulfoxide dppf 1 , 1’ -ferrocenediyl -bis(diphenylphosphine) dtbbpy 4,4’-Bis(l, l-dimethylethyl)-2,2’-bipyridine dtbpy 4,4 ’ -Di-tert-butyl-2,2 ’ -dipyridyl

EDCI l-ethyl-3-(3-dimethylaminopropyl)carbodiimide equiv. equivalents

ESI electrospray ionization

Et ethyl

Et2O diethyl ether

EtOAc ethyl acetate

EtOH ethanol

FA formic acid

HATU ( l-|bis(dimcthylamino)mcthylcnc|-l//-l.2.3-triazolo|4.5-/)|py ridinium

3 -oxide hexafluorophosphate

HMDS bis(trimethylsilyl)amine

HOBt hydoxybenzotriazole

HPLC high pressure liquid chromatography

PrOH isopropyl alcohol

Ir[dF(CF3)ppy]2(dtbpy)(PFe) [4,4 ’ -bis( 1 , l-dimethylethyl)-2,2’-bipyridine-Nl,N l’]bis[3,5-difluoro-2-

[5-(trifluoromethyl)-2-pyridinyl-N]phenyl-C]iridium(III) hexafluorophosphate

LC-MS high-performance liquid chromatography

LDA lithium diisopropylamide mCPBA meta-chloroperoxybenzoic acid

Me methyl

Me OH methanol

Ms methanesulfonyl

NMR nuclear magnetic resonance

NPLC normal phase liquid chromatography

PE petroleum ether ppy 2-phenylpyridine psi pounds per square inch PTSA para toluene sulfonic acid

Qphos l,2,3,4,5-Pentaphenyl-r-(di-tert-butylphosphino)ferrocene

RT room temperature

RuPhos-Pd-G3 (2-dicyclohexylphosphino-2 ’ ,6 ’ -diisopropoxy- 1,1’ -biphenyl) [2-(2 ’ - amino- l,l’-biphenyl)]palladium(II) methanesulfonate (CAS # 1445085- 77-7) sat. saturated

SFC supercritical fluid chromatography sol. solution

TBD triazabicyclodecene

TBDMS tert-butyldimethylsilyl t-BuXphos-Pd-G3 [(2-Di-tert-butylphosphino-2’,4’,6’-triisopropyl-l,l� �-biphenyl)-2-(2’- amino-1,1’ -biphenyl)] palladium(II) methanesulfonate (CAS # 1447963- 75-8)

TEA triethylamine

Tf triflyl

TFA trifluoroacetic acid

TFAA trifluoroacetic acid anhydride

THF tetrahydrofuran

TLC thin layer chromatography

Example 1

(2-(3-chlorophenyl)-6-(5,6-dimethoxy-lH-benzo[d]imidazol- l-yl)pyridin-3-yl)methanol

Step 1: methyl 2-chloro-6-(5,6-dimethoxy-lH-benzo[d]imidazol-l-yl)nicotinat e

In a 200 mL four-necked flask, NaH 60% dispersion in mineral oil (637 mg, 15.9 mmol, 2 equiv.) was combined with DMF (30 mL) to give a grey suspension. The mixture was cooled to 0 °C and 5,6-dimethoxy-lH-benzo[d]imidazole (1.42 g, 7.97 mmol, 1 equiv.) was added. The reaction mixture was stirred for 15 min. A solution of methyl 2,6-dichloronicotinate (1.64 g, 7.97 mmol, 1 equiv.) in DMF (10 mL) was added dropwise to the reaction mixture and stirring was continued for 15 min . The reaction mixture was quenched with 30 mL of 1 M HC1 and a precipitate formed. The suspension was collected by filtration, washed with H2O and dried under high vacuum. The title compound (1.414 g, 46.9% yield) was obtained as a light brown solid. LC-MS: m/z = 348.1 [M+H] ⁺ , ESI pos. Step 2: methyl 2-(3-chlorophenyl)-6-(5,6-dimethoxy-lH-benzo[d]imidazol-l-yl )nicotinate

In a microwave vial were added methyl 2-chloro-6-(5,6-dimethoxy-lH-benzo[d]imidazol-l- yl)nicotinate (1 g, 2.88 mmol, 1 equiv.), 2 M Na2COs (5 mL, 10.1 mmol, 3.5 equiv.), 1,2- dimethoxyethane (15 mL), (3-chlorophenyl)boronic acid (674 mg, 4.31 mmol, 1.5 equiv.) and Pd(PPhs)4 (332 mg, 288 pmol, 0.1 equiv.). The vial was capped and heated in the microwave at 120 °C for 20 min. The reaction mixture was cooled to RT, diluted with 25 mL of H2O and 25 mL of ethylacetate. The aqueous phase was back extracted with DCM. The combined organic layers were dried over Na2SO4, filtered and concentrated. The residue was purified by flash chromatography (silica gel, 80 g, 0% to 5% MeOH in DCM). The chromatographied product was triturated in acetone, collected by filtration, washed with acetone and dried. The title compound (353 mg, 27.2% yield) was obtained as a light brown solid. LC-MS: m/z = 424.2 [M+H] ⁺ , ESI pos.

Step 3: (2-(3-chlorophenyl)-6-(5, 6-dimethoxy-lH-benzo[d]imidazol-l-yl)pyridin-3-yl)methanol

In a 100 mL round-bottomed flask, methyl 2-(3-chlorophenyl)-6-(5,6-dimethoxy-lH- benzo[d]imidazol-l-yl)nicotinate (317 mg, 748 pmol, 1 equiv.) was suspended in anhydrous THF (5 mL). The mixture was cooled to 0 °C and LiAlEL 1 M solution in THF (1.0 mL, 1 mmol, 1.34 equiv.) was added. Stirring at 0 °C was continued for 10 min. The reaction mixture was quenched with 1 M potassium sodium tartrate solution (25 mL) and diluted with DCM (50 mL). The layers were separated and the organic phase was concentrated to leave a yellow residue. This crude solid was purified by flash chromatography (silica gel, 25 g, 0-100% [DCM/Me0H/NH40H (95:5: 1)] in DCM). The title compound (218 mg, 73.6% yield) was obtained as a white solid. LC-MS: m/z = 396.2 [M+H] ⁺ , ESI pos.

Example 15 (2-(3-Chloro-2-fluorophenyl)-6-(5,6-dimethoxy-lH-benzo[d]imi dazol-l-yl)pyridin-3- yl)methanol Step 1: methyl 2-(3-chloro-2-fluorophenyl)-6-(5,6-dimethoxy-lH-benzo[d]imid azol-l- yl)nicotinate

Starting from methyl 2-chloro-6-(5,6-dimethoxy-lH-benzo[d]imidazol-l-yl)nicotinat e (obtained as in step 1 of example 1) (400 mg, 1.15 mmol, 1 equiv.) with (3-chloro-2-fluorophenyl)boronic acid (301 mg, 1.73 mmol, 1.5 equiv.), and following the procedure described in step 2 of example 2, the title compound (317 mg, 57.4% yield) was obtained as a light brown solid. LC- MS: m/z = 442.2 [M+H] ⁺ , ESI pos.

Step 2: (2-(3-chloro-2-fluorophenyl)-6-(5, 6-dimethoxy-lH-benzo[d]imidazol-l-yl)pyridin-3- yl)methanol

Following the procedure described in step 3 of example 1, the title compound (219 mg, 62.7% yield) was obtained as a light brown solid. LC-MS: m/z = 414.2 [M+H] ⁺ , ESI pos.

Example 16 (6-(5,6-Dimethoxy-lH-benzo [d] imidazol-l-yl)-2-(4-fluoro-2-methoxyphenyl)pyridin-3- yl)methanol Step 1: methyl 6-(5,6-dimethoxy-lH-benzo[d]imidazol-l-yl)-2-(4-fluoro-2- methoxyphenyl)nicotinate

Starting from methyl 2-chloro-6-(5,6-dimethoxy-lH-benzo[d]imidazol-l-yl)nicotinat e (obtained as in step 1 of example 1) (500 mg, 1.15 mmol, 1 equiv.) with (4-fluoro-2- methoxyphenyl)boronic acid (367 mg, 2.16 mmol, 1.5 equiv.), and following the procedure described in step 2 of example 2, the title compound (498 mg, 64.1% yield) was obtained as an off-white solid. LC-MS: m/z = 438.3 [M+H] ⁺ , ESI pos.

Step 2: (6-(5, 6-dimethoxy-lH-benzo[d]imidazol-l-yl)-2-(4-fluoro-2-methoxyp henyl)pyridin-3- yl)methanol

Following the procedure described in step 3 of example 1, The title compound (398 mg, quantitative yield) was obtained as an off-white solid. LC-MS: m/z = 410.2 [M+H] ⁺ , ESI pos.

Example 17 l-(6-(5,6-Dimethoxy-lH-benzo[d]imidazol-l-yl)-2-(4-fluoro-2- methoxyphenyl)pyridin-3- yl)ethan-l-ol Step 1: 6-(5, 6-dimethoxy-lH-benzo[d]imidazol-l-yl)-2-(4-fluoro-2- methoxyphenyl)nicotinaldehyde

In a 25 mL pear shape flask, (6-(5,6-dimethoxy-lH-benzo[d]imidazol-l-yl)-2-(4-fluoro-2- m ethoxyphenyl)pyri din-3 -yl)methanol (398 mg, 972 pmol, 1 equiv.) (obtained as in step 2 of example 16) was suspended in DCM (5 mL) . Dess-Martin periodinane (15% solution in DCM) (3.3 g, 2.4 mL, 1.17 mmol, 1.2 equiv.) was added. The reaction mixture soon turned to a light brown solution. A suspension formed a few moments later. After stirring for 10 min, the reaction mixture was quenched with H2O, diluted with DCM and 2 M Na2COs was added. The layers were separated and the aqueous layer was back extracted with DCM. The combined organic layers were dried over Na2SO4, filtered and concentrated to leave a yellow residue. This crude material was purified by flash chromatography (silica gel, 40 g, 0% to 100% [DCM/MeOH/NH4OH (95:5: 1)] in DCM). The title compound (357 mg, 72.1% yield) was obtained as a yellow solid. LC-MS: m/z = 408.2 [M+H] ⁺ , ESI pos.

Step 2: l-(6-(5, 6-dimethoxy-lH-benzo[d]imidazol-l-yl)-2-(4-fluoro-2-methoxyp henyl)pyridin-3- yl)ethan-l-ol

In a 25 mL pear shape flask, 6-(5,6-dimethoxy-lH-benzo[d]imidazol-l-yl)-2-(4-fluoro-2- methoxyphenyl)nicotinaldehyde (120 mg, 236 pmol, 1 equiv.) was suspended in anhydrous THF (2.5 mL). The mixture was cooled to 0 °C before MeMgBr (3.2 M solution in 2-MeTHF) (81 pL, 259 pmol, 1.1 equiv.) was added and the reaction mixture was stirred at 0 °C for 30 min. Additional MeMgBr (3.2 M solution in 2-MeTHF) (81 pL, 259 pmol, 1.1 equiv.) was added and stirring was continued for another 30 min. The reaction mixture was slowly quenched with H2O (5 mL) at 0 °C. Sat. aq. NH4CI solution (8 mL) was added and the mixture was diluted with DCM/MeOH 9: 1. The layers were separated and the aqueous phase was back-extracted with DCM/MeOH 9: 1. The combined organic layers were dried over Na2SO4, filtered and concentrated. The residue was purified by flash chromatography (silica gel, 25 g, 0% to 100% [DCM/Me0H/NH40H (95:5: 1)] in DCM). The chromatographied product was dissolved in CH3CN / H2O 1 : 1 and freeze-dried. The title compound (90 mg, 88.4% yield) was obtained as a white lyophilized solid. LC-MS: m/z = 424.3 [M+H] ⁺ , ESI pos. Example 18 l-(6-(5,6-Dimethoxy-lH-benzo[d]imidazol-l-yl)-2-(4-fluoro-2- methoxyphenyl)pyridin-3- yl)propan-l-ol

Starting from 6-(5,6-dimethoxy-lH-benzo[d]imidazol-l-yl)-2-(4-fluoro-2- methoxyphenyl)nicotinaldehyde (obtained as in step 1 of example 17) (110 mg, 216 pmol, 1 equiv.) with EtMgBr (3.0 M solution in diethyl ether) (108 pL, 324 pmol, 1.5 equiv.) and following the procedure described in step 2 of example 17, the title compound (66 mg, 56.6% yield) was obtained as a white lyophilized solid. LC-MS: m/z = 438.3 [M+H] ⁺ , ESI pos.

Example 19 l-(2-(3-Chlorophenyl)-6-(5,6-dimethoxy-lH-benzo[d]imidazol-l -yl)pyridin-3-yl)ethan-l-ol

Step 1: 2-(3-chlorophenyl)-6-(5, 6-dimethoxy-lH-benzo[d]imidazol-l-yl)nicotinaldehyde Starting from (2-(3-chlorophenyl)-6-(5,6-dimethoxy-lH-benzo[d]imidazol-l-y l)pyridin-3- yl)methanol (obtained as in step 3 of example 1) (218 mg, 551 pmol, 1 equiv.) and following the procedure described in step 1 of example 17, the title compound (250 mg, quantitative yield) was obtained as a yellow amorphous solid. LC-MS: m/z = 394.1 [M+H] ⁺ , ESI pos.

Step 2: l-(2-(3-chlorophenyl)-6-(5,6-dimethoxy-lH-benzo[d]imidazol-l -yl)pyridin-3-yl)ethan-l- ol

Following the procedure described in step 2 of example 17, the title compound (120 mg, 84.3% yield) was obtained as a white lyophilized solid. LC-MS: m/z = 410.2 [M+H] ⁺ , ESI pos.

Example 20 l-(2-(3-Chloro-2-fluorophenyl)-6-(5,6-dimethoxy-lH-benzo[d]i midazol-l-yl)pyridin-3- yl)ethan-l-ol

Step 1: methyl 2-(3-chloro-2-fluorophenyl)-6-(5,6-dimethoxy-lH-benzo[d]imid azol-l- yl)nicotinate

Starting from methyl 2-chloro-6-(5,6-dimethoxy-lH-benzo[d]imidazol-l-yl)nicotinat e (obtained as in step 1 of example 1) (400 mg, 1.15 mmol, 1 equiv.) with (3-chloro-2-fluorophenyl)boronic acid (301 mg, 1.73 mmol, 1.5 equiv.), and following the procedure described in step 2 of example 1, the title compound (317 mg, 57.4% yield) was obtained as a light brown solid. LC- MS: m/z = 442.2 [M+H] ⁺ , ESI pos. Step 2: (2-(3-chloro-2-fluorophenyl)-6-(5, 6-dimethoxy-lH-benzo[d]imidazol-l-yl)pyridin-3- yl)methanol

Following the procedure described in step 3 of example 1, the title compound (219 mg, 62.7% yield) was obtained as a light brown solid. LC-MS: m/z = 414.2 [M+H] ⁺ , ESI pos.

Step 3: 2-(3-chloro-2-fluorophenyl)-6-(5, 6-dimethoxy-lH-benzo[d]imidazol-l- yl)nicotinaldehyde

Following the procedure described in step 1 of example 17, the title compound (137 mg, 49.1% yield) was obtained as a yellow solid. LC-MS: m/z = 412.2 [M+H] ⁺ , ESI pos.

Step 4: l-(2-(3-chloro-2-fluorophenyl)-6-(5, 6-dimethoxy-lH-benzo[d]imidazol-l-yl)pyridin-3- yl)ethan-l-ol

Following the procedure described in step 2 of example 17, the title compound (104 mg, 66.5% yield) was obtained as a white lyophilized solid. LC-MS: m/z = 428.2 [M+H] ⁺ , ESI pos. Example 21

(3)-l-(6-(5,6-Dimethoxy-lH-benzo[d]imidazol-l-yl)-2-(4-fl uoro-2-methoxyphenyl)pyridin-

3-yl)ethan-l-ol l-(6-(5,6-dimethoxy-lH-benzo[d]imidazol-l-yl)-2-(4-fluoro-2- methoxyphenyl)pyri din-3- yl)ethan-l-ol (60 mg, 142 pmol) (obtained as in step 2 of example 17) was purified by chiral SFC: column Chiral IA (250mm x 20mm x 5pm). 30 % (MeOH/EtOH/IprOH 1 : 1 : 1) in scCCE. The title compound (22.5 mg, 36% yield) was obtained as a white lyophilized solid. LC-MS: m/z = 424.2 [M+H] ⁺ , ESI pos. Example 22

(l?)-l-(6-(5,6-Dimethoxy-lH-benzo[d]imidazol-l-yl)-2-(4-f luoro-2-methoxyphenyl)pyridin-

3-yl)ethan-l-ol l-(6-(5,6-dimethoxy-lH-benzo[d]imidazol-l-yl)-2-(4-fluoro-2- methoxyphenyl)pyri din-3- yl)ethan-l-ol (60 mg, 142 pmol) (obtained as in step 2 of example 17) was purified by chiral SFC: column Chiral IA (250mm x 20mm x 5pm). 30 % (MeOH/EtOH/IprOH 1 : 1 : 1) in scCCE. The title compound (31.9 mg, 53.2% yield) was obtained as a white lyophilized solid. LC-MS: m/z = 424.2 [M+H] ⁺ , ESI pos. Example 23 Cyclopropyl(6-(5,6-dimethoxy-lH-benzo[d]imidazol-l-yl)-2-(4- fluoro-2- methoxyphenyl)pyridin-3-yl)methanol Starting from 6-(5,6-dimethoxy-lH-benzo[d]imidazol-l-yl)-2-(4-fluoro-2- methoxyphenyl)nicotinaldehyde (obtained as in step 1 of example 17) (164 mg, 322 pmol, 1 equiv.) with cyclopropyl magnesium bromide (1 M solution in 2-MeTHF) (419 pL, 419 pmol, 1.3 equiv.) and following the procedure described in step 2 of example 17, the title compound (64.6 mg, 43.7% yield) was obtained as a white lyophilized solid. LC-MS: m/z = 450.3 [M+H] ⁺ , ESI pos.

Example 24 l-(2-(3-Chlorophenyl)-6-(5,6-dimethoxy-lH-benzo[d]imidazol-l -yl)pyridin-3-yl)propan-l- Starting from 2-(3-chlorophenyl)-6-(5,6-dimethoxy-lH-benzo[d]imidazol-l-yl )nicotinaldehyde (obtained as in step 1 of example 19) (125 mg, 286 pmol, 1 equiv.) and following the procedure described in example 18, the title compound (80 mg, 66.1% yield) was obtained as a white lyophilized solid. LC-MS: m/z = 424.2 [M+H] ⁺ , ESI pos. Example 25 (2-(3-Chlorophenyl)-6-(5,6-dimethoxy-lH-benzo[d]imidazol-l-y l)pyridin-3- yl)(cyclopropyl)methanol Starting from 2-(3-chlorophenyl)-6-(5,6-dimethoxy-lH-benzo[d]imidazol-l-yl )nicotinaldehyde (obtained as in step 1 of example 19) (89 mg, 226 pmol, 1 equiv.) and following the procedure described in example 23, the title compound (65 mg, 66% yield) was obtained as a white lyophilized solid. LC-MS: m/z = 436.2 [M+H] ⁺ , ESI pos.

Example 26 (6-(5,6-Dimethoxy-lH-benzo [d] imidazol-l-yl)-2-morpholinopyridin-3-yl)methanol

Step 1: methyl 6-(5,6-dimethoxy-lH-benzo[d]imidazol-l-yl)-2-morpholinonicot inate

A mixture of methyl 2-chloro-6-(5,6-dimethoxy-lH-benzo[d]imidazol-l-yl)nicotinat e (174 mg, 0.5 mmol, 1 equiv.) (obtained as in step 1 of example 1) and morpholine (3.3 g, 3.3 mL, 37.9 mmol, 75.8 equiv.) in a sealed tube was heated to 100 °C and stirred for 1 hours. The reaction mixture was then cooled down to RT and purified by flash chromatography (silica gel, 20 g, 0- 100% [DCM/MeOH (9: 1)] in DCM). The title compound (128 mg, 61% yield) was obtained as a light brown solid. LC-MS: m/z = 399.3 [M+H] ⁺ , ESI pos. Step 2: (6-(5, 6-dimethoxy-lH-benzo[d]imidazol-l-yl)-2-morpholinopyridin-3- yl)methanol

LiAlH4 (11.4 mg, 300 pmol, 1 equiv.) was suspended in dry THF (0.3 mL). The suspension was cooled to 0 °C and a solution of methyl 6-(5,6-dimethoxy-lH-benzo[d]imidazol-l-yl)-2- morpholinonicotinate (120 mg, 0.3 mmol, 1 equiv.) in dry THF (1.6 mL) was added dropwise for 15 min while keeping the temperature at 0 °C. Stirring at 0 °C was continued for 4 hours. The cooling bath was removed and the mixture was stirred at RT overnight. The mixture was cooled again to 0 °C, carefully treated with H2O and extracted with DCM. The organic layer was washed with brine, dried over MgSCh, filtered and concentrated to dryness. The residue was purified by flash chromatography (silicagel, 10 g, 20-100% [DCM/MeOH (9: 1)] in DCM). The chromatographied product was triturated in Et2O (3 mL), collected by filtration, washed with Et2O and dried. The tilte compound (51 mg, 45.9% yield) was obtained as a white solid. LC-MS: m/z = 371.2 [M+H] ⁺ , ESI pos.

Example 27 (6-(5,6-Dimethoxy-lH-benzo[d]imidazol-l-yl)-2-(pyrrolidin-l- yl)pyridin-3-yl)methanol

Step 1: methyl 6-(5,6-dimethoxy-lH-benzo[d]imidazol-l-yl)-2-(pyrrolidin-l-y l)nicotinate

A mixture of methyl 2-chloro-6-(5,6-dimethoxy-lH-benzo[d]imidazol-l-yl)nicotinat e (174 mg, 0.5 mmol, 1 equiv.) (obtained as in step 1 of example 1), pyrrolidine (53 mg, 62 pL, 750 pmol, 1.5 equiv.) and K2CO3 (131 mg, 950 pmol, 1.9 equiv.) in DMSO (1.7 mL) was heated to 95 °C and stirred at that temperature for 3 hours. The mixture was cooled to RT and diluted with H2O. A precipitate formed. The solid was collected by filtration and dissolved in DCM. The resulting solution was dried over MgSCh, filtered and concentrated to leave the title compound (150 mg, 76.1% yield) as a white solid. LC-MS: m/z = 383.2 [M+H] ⁺ , ESI pos. Step 2: (6-(5, 6-dimethoxy-lH-benzo[d]imidazol-l-yl)-2-(pyrrolidin-l-yl)pyr idin-3-yl)methanol

Following the procedure described in step 2 of example 26, the title compound (86 mg, 56.7% yield) was obtained as an off-white solid. LC-MS: m/z = 355.2 [M+H] ⁺ , ESI pos.

Example 28 (6-(5,6-Dimethoxy-lH-benzo [d] imidazol-l-yl)-2-(piperidin-l-yl)pyridin-3-yl)methanol

Step 1: methyl 6-(5,6-dimethoxy-lH-benzo[d]imidazol-l-yl)-2-(piperidin-l-yl )nicotinate

Starting from 2-chloro-6-(5,6-dimethoxy-lH-benzo[d]imidazol-l-yl)nicotinat e (obtained as in step 1 of example 1) (164 mg, 322 pmol, 1 equiv.) with piperidine (63.9 mg, 74.1 pL, 750 pmol, 1.5 equiv.) and following the procedure described in step 1 of example 27, the title compound (150 mg, 71.3% yield) was obtained as a light red solid. LC-MS: m/z = 397.3 [M+H] ⁺ , ESI pos.

Step 2: (6-(5,6-dimethoxy-lH-benzo[d]imidazol-l-yl)-2-(piperidin-l-y l)pyridin-3-yl)methanol

Following the procedure described in step 2 of example 26, the title compound (93.9 mg, 61.7% yield) was obtained as an off-white solid. LC-MS: m/z = 369.2 [M+H] ⁺ , ESI pos.

Example 32 5-((6-(5,6-Dimethoxy-lH-benzo[d]imidazol-l-yl)-3-(hydroxymet hyl)pyridin-2- yl)amino)pentan-l-ol

Step 1: methyl 6-chloro-2-(2-oxopiperidin-l-yl)nicotinate To a suspension of NaH 60% dispersion in mineral oil (208 mg, 5.2 mmol, 1 equiv.) in dry DMF (31 mL) was added piperidin-2-one (515 mg, 5.2 mmol, 1 equiv.) and the reaction mixture was stirred at 23 °C for 30 minutes. The reaction mixture was cooled to 0 °C and methyl 6-chloro-2- fluoronicotinate (986 mg, 5.2 mmol, 1 equiv.) was added. The cooling bath was removed and the solution was allowed to warm up to 23 °C. Stirring was continued for 1 hours. The reaction mixture was added to ice-cold saturated aqueous NH4CI solution (100 mL). and extracted with EtOAc. The combined organics were washed with brine, dried over MgSCh, filtered and concentrated to leave a light yellow liquid. This crude material was purified by flash chromatography (silicagel, 20 g, 0-80% heptane in EtOAc). The title compound (791 mg, 53.8% yield) was obtained as a light yellow solid. LC-MS: m/z = 269.1 [M+H] ⁺ , ESI pos. Step 2: methyl 6-(5, 6-dimethoxy-lH-benzo[d]imidazol-l-yl)-2-(2-oxopiperidin-l-yl )nicotinate

A suspension of sodium hydride (60 % dispersion in mineral oil) (20 mg, 0.5 mmol, 1.0 equiv.) in dry DMF (1.9 ml) was cooled to 0 °C and 5,6-dimethoxy-lH-benzo[d]imidazole (89.1 mg, 0.5 mmol, 1.0 equiv.) was added and the reaction mixture was stirred for 15 min . Methyl 6-chloro- 2-(2-oxopiperidin-l-yl)nicotinate.(134 mg, 0.5 mmol, 1.0 equiv.) was dissolved in dry DMF (600 pl) ) and the solution was added dropwise. Stirring was continued for 15 min at 0 °C then let to warm overnight to RT. The reaction mixture was cooled, and diluted with cold sat. aq. NH4CI sol. and extracted with EtOAc. The combined organic layers were washed with brine, dried over MgSC and concentrated unde rreduced pressure. The crude productwas purified by flash column chromatography (silica gel, 0 - 10% MeOH in DCM) to yield the title compound (62.5 mg, 28.9% yield) was obtained as an off-white solid. LC-MS: m/z = 411.2 [M+H] ⁺ , ESI pos.

Step 3: 5-((6-(5, 6-Dimethoxy-lH-benzo[d]imidazol-l-yl)-3-(hydroxymethyl)pyrid in-2- yl)amino)pentan-l-ol

To a stirred solution of methyl 6-(5,6-dimethoxy-lH-benzo[d]imidazol-l-yl)-2-(2-oxopiperidin - l-yl)nicotinate (62 mg, 0.15 mmol, 1 equiv.) in a mixture of dry THF (560 pL) and ethanol (560 pL) was added calcium chloride (58 mg, 525 pmol, 3.5 equiv.). The reaction mixture was cooled to 0 °C. NaBT (25 mg, 675 pmol, 4.5 equiv.) was added in one portion and the mixture was stirred for 10 min. The cooling bath was removed and stirring at RT was continued for 2 hours. The mixture was poured into ice-cold sat. aq. NH4CI sol. (50 mL) and this was extracted with DCM. The organic layer was washed with brine, dried over MgSCU, filtered and concentrated to dryness. The crude product was purified by prep. HPLC. The title compound (19.5 mg, 30.6% yield) was obtained as an off-white solid. LC-MS: m/z = 387.2 [M+H] ⁺ , ESI pos. 1H NMR (600 MHz, DMSO-t/6): 5 ppm 8.66 (s, 1 H), 7.93 (s, 1 H), 7.54 (d, J = 7.8 Hz, 1 H), 7.28 (s, 1 H), 6.94 (d, J= 7.7 Hz, 1 H), 6.20 (t, J = 5.3 Hz, 1 H), 5.27 (s, 1 H), 4.43 (d, J = 5.3 Hz, 2 H), 4.34 (s, 1 H), 3.83 (d, J= 6.4 Hz, 6 H), 3.47 - 3.53 (m, 2 H), 3.38 (d, J= 5.1 Hz, 2 H), 1.65 (br t, J= 7.3 Hz, 2 H), 1.42 - 1.48 (m, 2 H), 1.35 - 1.41 (m, 2 H).

Example 33 l-(6-(5,6-Dimethoxy-lH-benzo[d]imidazol-l-yl)-3-(hydroxymeth yl)pyridin-2-yl)pyrrolidin- 2-one

Step 1: methyl 6-chloro-2-(2-oxopyrrolidin-l-yl)nicotinate

Following the procedure described in step 1 of example 32 with pyrrolidin-2-one (443 mg, 5.2 mmol, 1 equiv.), the title compound (744 mg, 53.4% yield) was obtained as an orange liquid. LC-MS: m/z = 255.1 [M+H] ⁺ , ESI pos.

Step 2: methyl 6-(5, 6-dimethoxy-lH-benzo[d]imidazol-l-yl)-2-(2-oxopyrrolidin-l-y l)nicotinate

Following the procedure described in step 2 of example 32 (with reaction time of 21 hours at RT), the title compound (236 mg, 56.6% yield) was obtained as an off-white solid. LC-MS: m/z = 397.2 [M+H] ⁺ , ESI pos.

Step 3: l-(6-(5, 6-Dimethoxy-lH-benzo[d]imidazol-l-yl)-3-(hydroxymethyl)pyrid in-2- yl)pyrrolidin-2-one

Following the procedure described in step 2 of example 26 and starting from methyl 6-(5,6- dimethoxy-lH-benzo[d]imidazol-l-yl)-2-(2-oxopyrrolidin-l-yl) nicotinate (119 mg, 0.3 mmol), the title compound (93.9 mg, 61.7% yield) was obtained as an off-white solid. LC-MS: m/z = 369.2 [M+H] ⁺ , ESI pos.

Example 34 4-((6-(5,6-Dimethoxy-lH-benzo[d]imidazol-l-yl)-3-(hydroxymet hyl)pyridin-2- yl)amino)butan-l-ol The title compound (19.1 mg, 16.2% yield) was isolated as a side-product during the preparation of example 33 and was obtained as an off-white solid. LC-MS: m/z = 373.2 [M+H] ⁺ , ESI pos.

Example 35 (5)-2-(6-(5,6-Dimethoxy-lH-benzo[d]imidazol-l-yl)-3-(l-hydro xyethyl)pyridin-2- yl)benzamide

Step 1: (2-chloro-6-(5, 6-dimethoxy-lH-benzo[d]imidazol-l-yl)pyridin-3-yl)methanol

Starting from methyl 2-chloro-6-(5,6-dimethoxy-lH-benzo[d]imidazol-l-yl)nicotinat e (obtained as in step 1 of example 1) (1.18 g, 3.38 mmol) and following the procedure described in step 3 of example 1, the title compound (702 mg, 61% yield) was obtained as a brown solid. LC-MS: m/z = 320.1 [M+H] ⁺ , ESI pos.

Step 2: 2-chloro-6-(5, 6-dimethoxy-lH-benzo[d]imidazol-l-yl)nicotinaldehyde

Following the procedure described in step 1 of example 17, with a reaction time of 7 h, the title compound (752 mg, quantitative yield) was obtained as a light brown solid. LC-MS: m/z = 318.1 [M+H] ⁺ , ESI pos.

Step 3: l-(2-chloro-6-(5, 6-dimethoxy-lH-benzo[d]imidazol-l-yl)pyridin-3-yl)ethan-l-ol

Following the procedure described in step 2 of example 17, using methylmagnesium bromide solution (1.4M in THF/Toluene (1 :3)), the title compound (702 mg, 87.1% yield) was obtained as a yellow amorphous solid. LC-MS: m/z = 334.1 [M+H] ⁺ , ESI pos.

Step 4: l-(5-(l-((tert-butyldimethylsilyl)oxy)ethyl)-6-chloropyridin -2-yl)-5,6-dimethoxy-lH- benzo[d] imidazole

In a 150 mL round-bottomed flask, l-(2-chloro-6-(5,6-dimethoxy-lH-benzo[d]imidazol-l- yl)pyridin-3-yl)ethan-l-ol (702 mg, 2.1 mmol, 1 equiv.) was suspended in anhydrous DCM (15 mL). The mixture was sparged with argon before imidazole (286 mg, 4.21 mmol, 2 equiv.) and tert-butylchlorodimethylsilane (485 mg, 3.15 mmol, 1.5 equiv.) were added subsequently. The reaction mixture turned to a yellow suspension and it was stirred at 20 °C for 3 h, after which only a small conversion of the starting material to the desired product was observed. DMF (6 mL) was added to the mixture which turned to a solution. Stirring was continued at 20 °C overnight. The reaction mixture was quenched with H2O and extracted with DCM. The layers were separated and the aqueous phase was back-extracted using DCM. The combined organic layers were dried over Na2SO4, filtered and concentrated to dryness. The crude material was purified by flash chromatography (silica gel, 40 g, 0% to 100% EtOAc in heptane). The title compound (748 mg, 1.67 mmol, 79.4% yield) was obtained as a white solid. LC-MS: m/z=448.2 [M+H] ⁺ , ESI pos.

Step 5: 2-(6-(5, 6-dimethoxy-lH-benzo[d]imidazol-l-yl)-3-(l-hydroxyethyl)pyri din-2- yl)benzamide

Following the procedure described in step 2 of example 1, using 1 -(5 -(1 -((tertbutyl dimethylsilyl)oxy)ethyl)-6-chloropyridin-2-yl)-5,6-dimethoxy -lH-benzo[d]imidazole (80 mg, 179 pmol, 1 equiv.) and (2-cyanophenyl)boronic acid (39.4 mg, 268 pmol, 1.5 equiv.) with a reaction time of 30 min at 130 °C, the title compound (20 mg, 24.9% yield) was obtained as an off-white solid. LC-MS: m/z = 419.2 [M+H] ⁺ , ESI pos. Step 6: (S)-2-(6-(5,6-dimethoxy-lH-benzo[d]imidazol-l-yl)-3-(l-hydro xyethyl)pyridin-2- yl)benzamide

2-(6-(5,6-dimethoxy-lH-benzo[d]imidazol-l-yl)-3-(l-hydrox yethyl)pyridin-2-yl)benzamide (20 mg, 48 pmol) was purified by chiral SFC: column Chiral OD-H (250mm x 20mm x 5pm). Flow rate: 90 mL / min. 30 % MeOH in scCCh. The title compound (3.9 mg, 19.5% yield) was obtained as a white lyophilized solid. LC-MS: m/z = 419.2 [M+H] ⁺ , ESI pos.

Example 36

(l?)-2-(6-(5,6-Dimethoxy-lH-benzo[d]imidazol-l-yl)-3-(l-h ydroxyethyl)pyridin-2- yl)benzamide

2-(6-(5,6-dimethoxy-lH-benzo[d]imidazol-l-yl)-3-(l-hydrox yethyl)pyridin-2-yl)benzamide

(obtained as in step 5 of example 35) (20 mg, 48 pmol) was purified by chiral SFC: column Chiral OD-H (250mm x 20mm x 5pm). Flow rate: 90 mL / min. 30 % MeOH in scCO?. The title compound (6.5 mg, 32.5% yield) was obtained as a white lyophilized solid. LC-MS: m/z = 419.2 [M+H] ⁺ , ESI pos.

Example 37 (5)-3-(6-(5,6-Dimethoxy-lH-benzo[d]imidazol-l-yl)-3-(l-hydro xyethyl)pyridin-2- yl)benzonitrile

Step 1: 3-(6-(5, 6-dimethoxy-lH-benzo[d]imidazol-l-yl)-3-(l-hydroxyethyl)pyri din-2- yl)benzonitrile

Starting from l-(5-(l -((tert-butyl dimethylsilyl)oxy)ethyl)-6-chloropyridin-2-yl)-5,6-dimethoxy - lH-benzo[d]imidazole (obtained as in step 4 of example 35) (80 mg, 179 pmol, 1 equiv.) with (3-cyanophenyl)boronic acid (39 mg, 268 pmol, 1.5 equiv.) and following the procedure described in step 2 of example 1 with a reaction time of 30 min at 130 °C, the title compound (60 mg, 83.9% yield) was obtained as a brown solid. LC-MS: m/z = 401.1 [M+H] ⁺ , ESI pos.

Step 2: (S)-3-(6-(5,6-dimethoxy-lH-benzo[d]imidazol-l-yl)-3-(l-hydro xyethyl)pyridin-2- yl)benzonitrile

3-(6-(5,6-dimethoxy-lH-benzo[d]imidazol-l-yl)-3-(l-hydrox yethyl)pyri din-2 -yl)benzonitrile (60 mg, 179 pmol) was purified by chiral SFC: column Chiral OD-H (250mm x 20mm x 5pm). 30 % MeOH in scCCh. The title compound (5.3 mg, 8.8% yield) was obtained as a white lyophilized solid. LC-MS: m/z = 401.2 [M+H] ⁺ , ESI pos.

Example 38 (l?)-3-(6-(5,6-Dimethoxy-lH-benzo[d]imidazol-l-yl)-3-(l-hydr oxyethyl)pyridin-2- yl)benzonitrile

3-(6-(5,6-dimethoxy-lH-benzo[d]imidazol-l-yl)-3-(l-hydrox yethyl)pyri din-2 -yl)benzonitrile (obtained as in step 1 of example 37) (60 mg, 179 pmol) was purified by chiral SFC: column

Chiral OD-H (250mm x 20mm x 5pm). 30 % MeOH in scCCh. The title compound (5.8 mg, 9.7% yield) was obtained as a white lyophilized solid. LC-MS: m/z = 401.2 [M+H] ⁺ , ESI pos.

Example 39 (5)-4-(6-(5,6-Dimethoxy-lH-benzo[d]imidazol-l-yl)-3-(l-hydro xyethyl)pyridin-2- yl)benzonitrile Step 1: 4-(6-(5,6-dimethoxy-lH-benzo[d]imidazol-l-yl)-3-(l-hydroxyet hyl)pyridin-2- yl)benzonitrile

Starting from l-(5-(l -((tert-butyl dimethylsilyl)oxy)ethyl)-6-chloropyridin-2-yl)-5,6-dimethoxy - lH-benzo[d]imidazole (obtained as in step 4 of example 35) (80 mg, 179 pmol, 1 equiv.) with (4-cyanophenyl)boronic acid (39 mg, 268 pmol, 1.5 equiv.) and following the procedure described in step 2 of example 1 with a reaction time of 30 min at 130 °C, the title compound (26 mg, 36.4% yield) was obtained as an off-white solid. LC-MS: m/z = 401.2 [M+H] ⁺ , ESI pos. Step 2: (S)-4-(6-(5,6-dimethoxy-lH-benzo[d]imidazol-l-yl)-3-(l-hydro xyethyl)pyridin-2- yl)benzonitrile

4-(6-(5,6-dimethoxy-lH-benzo[d]imidazol-l-yl)-3-(l-hydrox yethyl)pyridin-2-yl)benzonitrile (26 mg, 65 pmol) was purified by chiral SFC: column Chiral OD-H (250mm x 20mm x 5pm). 30 % MeOH in scCO?. The title compound (7.1 mg, 27.3% yield) was obtained as a white lyophilized solid. LC-MS: m/z = 401.2 [M+H] ⁺ , ESI pos.

Example 40 (l?)-4-(6-(5,6-Dimethoxy-lH-benzo[d]imidazol-l-yl)-3-(l-hydr oxyethyl)pyridin-2- yl)benzonitrile

4-(6-(5,6-dimethoxy-lH-benzo[d]imidazol-l-yl)-3-(l-hydrox yethyl)pyridin-2-yl)benzonitrile

(obtained as in step 1 of example 39) (26 mg, 65 pmol) was purified by chiral SFC: column Chiral OD-H (250mm x 20mm x 5pm). 30 % MeOH in scCCh. The title compound (8.5 mg, 32.7% yield) was obtained as a white lyophilized solid. LC-MS: m/z = 401.2 [M+H] ⁺ , ESI pos.

Example 41 (5)-6-(5,6-Dimethoxy-lH-benzo[d]imidazol-l-yl)-3-(l-hydroxye thyl)-l'-methyl-[2,4'- bipyridin]-2'(l'H)-one

Step 1 : 6-(5, 6-dimethoxy-lH-benzo[ d]imidazol-l-yl)-3-( 1 -hydroxyethyl)-! ' -methyl- [ 2, 4 '- bipyridin ]-2 '( I 'H)-one

Starting from l-(5-(l -((tert-butyl dimethylsilyl)oxy)ethyl)-6-chloropyridin-2-yl)-5,6-dimethoxy - lH-benzo[d]imidazole (obtained as in step 4 of example 35) (80 mg, 179 pmol, 1 equiv.) with (l-methyl-2-oxo-l,2-dihydropyridin-4-yl)boronic acid (41 mg, 268 pmol, 1.5 equiv.) and following the procedure described in step 2 of example 1 with a reaction time of 30 min at 130 °C, the title compound (35 mg, 45.8% yield) was obtained as a white lyophilized solid. LC-MS: m/z = 407.2 [M+H] ⁺ , ESI pos.

Step 2: (S)-6-(5,6-dimethoxy-lH-benzo[d]imidazol-l-yl)-3-(l-hydroxye thyl)-l'-methyl-[2,4'- bipyridin ]-2 '( 1 'H)-one

6-(5,6-dimethoxy-lH-benzo[d]imidazol-l-yl)-3-(l-hydroxyet hyl)-r-methyl-[2,4'-bipyridin]- 2'(l'H)-one (35 mg, 86 pmol) was purified by chiral SFC: column Chiral OD-H (250mm x 20mm x 5um). 30 % MeOH in scCCh. The title compound (3.8 mg, 10.9% yield) was obtained as a white lyophilized solid. LC-MS: m/z = 407.2 [M+H] , ESI pos. Example 42 (l?)-6-(5,6-Dimethoxy-lH-benzo[d]imidazol-l-yl)-3-(l-hydroxy ethyl)-l'-methyl-[2,4'- bipyridin]-2'(l'H)-one

6-(5,6-dimethoxy-lH-benzo[d]imidazol-l-yl)-3-(l-hydroxyet hyl)-r-methyl-[2,4'-bipyridin]- 2'(l'H)-one (obtained as in step 1 of example 41) (35 mg, 86 pmol) was purified by chiral SFC: column Chiral OD-H (250mm x 20mm x 5pm). 30 % MeOH in scCCh. The title compound (11.3 mg, 32.3% yield) was obtained as a white lyophilized solid. LC-MS: m/z = 407.2 [M+H] ⁺ , ESI pos.

Example 53

1- [6- [5-(2-Morpholinoethoxy)benzimidazol-l-yl]-2-phenoxy-3-pyridy l] ethanol

Intermediate 1: l-(6-chloro-2-phenoxy-3-pyridyl)ethanone

To a solution of l-(6-chloro-2-fhioro-3-pyridyl)ethanone (CAS# 1260663-13-5, 500 mg, 2.88 mmol, 1 equiv.) in CH3CN (8 mL) were added phenol (0.2 mL, 2.88 mmol, 1 equiv.) and K2CO3 (796 mg, 5.76 mmol, 2 equiv.). The reaction mixture was stirred at 30 °C for 12 hours. The reaction mixture was concentrated under reduced pressure. The residue was taken in EtOAc and H2O. The aqueous phase was back-extracted with EtOAc. The combined organics were washed with brine, dried over anhydrous Na2SO4, filtered and concentrated. The residue was purified by flash chromatography (silicagel, 0% to 30% EtOAc in petroleum ether). The title compound (1.17 g, quantitative yield) was obtained as a colorless oil. LC-MS: m/z = 248.0 [M+H] ⁺ , ESI pos.

Intermediate 2, step 1: 4- [2-(4-nitrophenoxy)ethyl] morpholine

To a stirred solution of 4-nitrophenol (5.0 g, 35.94 mmol, 1 equiv.), 2-morpholinoethanol (5.89 g, 35.94 mmol, 1 equiv.) and triphenylphosphine (10.37 g, 39.54 mmol, 1.1 equiv.) in THF (80 mL) was added dropwise a solution of DEAD (6.89 g, 39.54 mmol, 1.1 equiv.) in THF (20 mL) at 0 °C under a nitrogen atmosphere. The mixture was then stirred at 30 °C for 16 hours. The reaction mixture was poured into H2O (200 mL) and extracted with ethyl acetate (3 x 200 mL). The combined organic layers were dried over anhydrous ISfeSCU, filtered and concentrated in vacuo. The residue was purified by flash chromatography (silicagel, 10% MeOH in EtOAc). The title compound (3.6 g, 39.7% yield) was obtained as an off-white solid. LC-MS: m/z = 253.0 [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, CD3OD): 5 = 8.25 - 8.18 (m, 2H), 7.14 - 7.08 (m, 2H), 4.27 (t, J= 5.4 Hz, 2H), 3.75 - 3.68 (m, 4H), 2.85 (t, J= 5.5 Hz, 2H), 2.64 - 2.56 (m, 4H).

Intermediate 2, step 2: 4-(2-morpholin-4-ylethoxy)aniline

To a solution of 4-[2-(4-nitrophenoxy)ethyl]morpholine (3.5 g, 13.87 mmol, 1 equiv.) in MeOH (40 mL) was added 10% Pd/C (0.67 g, 0.630 mmol, 0.050 equiv.). The mixture was stirred at 25 °C for 16 h under H2 (15 psi). The mixture was filtered and the filtrate was concentrated in vacuo to afford the crude title compound (2.7 g, 87.5% yield) as light yellow solid. LC-MS: m/z = 223.1 [M+H] ⁺ , ESI pos.

Intermediate 2, step 3: N-[4-(2-morpholinoethoxy)phenyl] acetamide

To a stirred solution of 4-(2-morpholin-4-ylethoxy)aniline (2.7 g, 12.15 mmol, 1 equiv.) and triethylamine (5.1 mL, 36.44 mmol, 3 equiv.) in DCM (30 mL) was added acetic anhydride (1.49 g, 14.58 mmol, 1.2 equiv.) at 0 °C. Then the mixture was stirred at 25 °C for 16 h under a nitrogen atmosphere. Then the mixture was poured into H2O (100 mL) and extracted with EtOAc (3 x 100 mL). The combined organic layers were dried over anhydrous Na2SO4, filtered and concentrated in vacuo. The residue was purified by flash chromatography (silica gel, 50% to 100% EtOAc in petroleum ether). The title compound (2.2 g, 74% yield) was obtained as a white solid. LC-MS: m/z = 265.1 [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, CDCI3): 8 = 7.41 - 7.36 (m, 2H), 7.17 (br s, 1H), 6.90 - 6.83 (m, 2H), 4.10 (t, J= 5.7 Hz, 2H), 3.77 - 3.73 (m, 4H), 2.81 (t, J = 5.7 Hz, 2H), 2.62 - 2.57 (m, 4H), 2.16 (s, 3H).

Intermediate 2, step 4: N-[4-(2-morpholinoethoxy)-2-nitro-phenyl] acetamide

To a stirred solution of N-[4-(2-morpholinoethoxy)phenyl]acetamide (1.8 g, 6.81 mmol, 1 equiv.) in acetic anhydride (20 mL, 180.35 mmol, 26.48 equiv.) was added dropwise nitric acid (2.6 mL, 37.88 mmol, 5.56 equiv.) at 0 °C. The cooling bath was removed and the mixture was stirred at 20 °C for another 1 hours. The mixture was quenched by the careful addition of ice- cold H2O (150 mL). The mixture was then basified by the addition of 1 N NaOH until to pH 9 was reached. This was extracted with EtOAc (4 x 50 mL). The combined organic extracts were dried over anhydrous ISfeSCU, filtered and concentrated in vacuo to afford the crude title compound (1.8 g, 85.4% yield) as a red oil. LC-MS: m/z = 310.1 [M+H] ⁺ , ESI pos.

Intermediate 2, step 5: 4-(2-morpholinoethoxy)-2-nitro-aniline

To a stirred solution of of N-[4-(2-morpholinoethoxy)-2-nitro-phenyl]acetamide (1.8 g, 3.23 mmol, 1 equiv.) in a mixture of EtOH (15 mL) and H2O (5 mL) was added potassium hydroxide (1.63 g, 29.1 mmol, 5 equiv.). The mixture was stirred at 80 °C for 4 hours. The reaction mixture was coold to RT and poured into H2O (100 mL). This was extracted with EtOAc (3 x 50 mL). The combined organic layers were dried over anhydrous Na2SO4, filtered and concentrated in vacuo to afford the crude title compound (1.2 g, 77.1% yield) as red oil. LC-MS: m/z = 268.2 [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, CDCI3): 6 = 7.58 (d, J = 2.9 Hz, 1H), 7.12 - 7.07 (m, 1H), 6.76 (d, J = 9.0 Hz, 1H), 4.09 (t, J = 5.6 Hz, 2H), 3.77 - 3.74 (m, 4H), 2.80 (t, J = 5.6 Hz, 2H), 2.61 - 2.57 (m, 4H).

Step 1: 1- [6- [4-(2-morpholinoethoxy)-2-nitro-anilino]-2-phenoxy-3-pyridyl ] ethanone

To a stirred solution of 4-(2-morpholinoethoxy)-2-nitro-aniline (intermediate 2 of example 53) (150 mg, 0.56 mmol, 1 equiv.) in 1,4-dioxane (3 mL) were added l-(6-chloro-2-phenoxy-3- pyridyl)ethanone (intermediate 1 of example 53) (139 mg, 0.56 mmol, 1 equiv.), K2CO3 (233 mg, 1.68 mmol, 3 equiv.), Xantphos (130 mg, 0.22 mmol, 0.4 equiv.) and Pd2(dba)3 (103 mg, 0.110 mmol, 0.200 equiv.). The reaction mixture was stirred at 100 °C for 12 hours. The reaction mixture cooled to RT, poured into H2O (30 mL) and extracted with EtOAc (3 x 30 mL). The combined organic layers were washed with brine (2 x 30 mL), dried over ISfeSCU, filtered and concentrated under reduced pressure. The crude material was purified by flash chromatography (silica gel, 0% to 100% EtOAc in petroleum ether). The title compound (230 mg, 75.4% yield) was obtained as an orange solid. LC-MS: m/z = 479.2 [M+H] ⁺ , ESI pos.

Step 2: l-[6-[2-amino-4-(2-morpholinoethoxy)anilino]-2-phenoxy-3-pyr idyl] ethanone

Following the procedure described in step 2, intermediate 2 of example 53, the title compound (160 mg, 94.8% yield) was obtained as light brown solid. LC-MS: m/z = 449.2 [M+H] ⁺ , ESI pos.

Step 3: l-[6-[5-(2-morpholinoethoxy)benzimidazol-l-yl]-2-phenoxy-3-p yridyl] ethanone A solution of l-[6-[2-amino-4-(2-morpholinoethoxy)anilino]-2-phenoxy-3-pyr idyl]ethanone (140 mg, 0.31 mmol, 1 equiv.) in trimethyl orthoformate (10 mL, 6.24 mmol, 20 equiv.) was stirred at 125 °C for 24 hours. Then the reaction mixture was stirred at 130 °C for another 24 hours. The reaction mixture was cooled and concentrated to dryness. The residue was suspended in MeOH (10 mL). The solid was collected was collected by filtration, washed with MeOH and dried. The title compound (70 mg, 48.9% yield) was obtained as an off-white solid. LC-MS: m/z = 479.2 [M+H] ⁺ , ESI pos.

Step 4: l-[6-[5-(2-morpholinoethoxy)benzimidazol-l-yl]-2-phenoxy-3-p yridyl] ethanol

To a stirred solution of l-[6-[5-(2-morpholinoethoxy)benzimidazol-l-yl]-2-phenoxy-3- pyridyl] ethanone (70 mg, 0.15 mmol, 1 equiv.) in MeOH (2 mL) was added NaBE (17 mg, 0.46 mmol, 3 equiv.) at 0 °C. The cooling bath was removed and the mixture was stirred at 30 °C for 2 hours. The reaction mixture was quenched by the addition of saturated aq. NH4CI solution. This was extracted with EtOAc (3 x 10 mL). The combined organic layers were washed with brine, dried over anhydrous ISfeSCU, filtered and concentrated. The crude material was purified by preparative HPLC. Column Phenomenex Gemini -NX C18 (75mm x 30mm x 3 pm). Flow rate 30 mL / min. Gradient: 24% to 54% CH3CN in (10 mM NH4HCO3 in H2O) (8 min) then 100% CH3CN (2 min). The title compound (47.6 mg, 67% yield) was obtained as a white solid. LC- MS: m/z = 461.2 [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, CD3OD): 5 = 8.68 (s, 1H), 8.12 (d, J= 8.1 Hz, 1H), 7.54 - 7.48 (m, 3H), 7.39 - 7.31 (m, 2H), 7.22 (br d, J= 7.6 Hz, 2H), 7.14 (s, 1H), 6.64 (br d, J= 9.4 Hz, 1H), 5.34 - 5.25 (m, 1H), 4.18 - 4.11 (m, 2H), 3.75 - 3.68 (m, 4H), 2.81 (br t, J= 5.1 Hz, 2H), 2.60 (br s, 4H), 1.58 (d, J= 6.4 Hz, 3H).

Example 55 l-[2-Anilino-6-[5-(2-morpholinoethoxy)benzimidazol-l-yl]-3-p yridyl] ethanol

Step 1: l-(2-anilino-6-chloro-3-pyridyl)ethanone

To a stirred solution of l-(6-chloro-2-fluoro-3-pyridyl)ethanone (CAS# 1260663-13-5, 500 mg, 2.88 mmol, 1 equiv.) in CH3CN (8 mL) was added aniline (0.26 mL, 2.88 mmol, 1 equiv.) and

DIPEA (796 mg, 5.76 mmol, 2 equiv.). The reaction mixture was then stirred at 80 °C for 20 hours. The reaction mixture was cooled to RT, concentrated in vacuo and the residue was purified by flash chromatography (silica gel, 0% to 100% EtOAc in petroleum ether). The title compound (400 mg, 56.3% yield) was obtained as a yellow solid. LC-MS: m/z = 247.0 [M+H] ⁺ , ESI pos.

Step 2: l-[2-anilino-6-[4-(2-morpholinoethoxy)-2-nitro-anilino]-3-py ridyl] ethanone

Following the procedure described in step 2 of example 53, the title compound (200 mg, 51.7% yield) was obtained as a red solid. LC-MS: m/z = 478.3 [M+H] ⁺ , ESI pos. Step 3: l-[6-[2-amino-4-(2-morpholinoethoxy)anilino]-2-anilino-3-pyr idyl] ethanone Following the procedure described in step 2, intermediate 2 of example 53, the title compound (160 mg, 85.3% yield) was obtained as a yellow oil. LC-MS: m/z = 448.4 [M+H] ⁺ , ESI pos.

Step 4: l-[2-anilino-6-[5-(2-morpholinoethoxy)benzimidazol-l-yl]-3-p yridyl] ethanone Following the procedure described in step 3 of example 53, the title compound (90 mg, 80% yield) was obtained as a yellow oil. LC-MS: m/z = 458.2 [M+H] ⁺ , ESI pos.

Step 5: l-[2-anilino-6-[5-(2-morpholinoethoxy)benzimidazol-l-yl]-3-p yridyl] ethanol

Following the procedure described in step 4 of example 53, the title compound (34.1 mg, 42.4% yield) was obtained as a pink lyophilized solid after purification by preparative HPLC: Column

Waters Xbridge (150mm x 25mm x 5pm). Flow rate 25 mL / min. Gradient: 29% to 59% CH ₃ CN in (10 mM NH4HCO3 in H ₂ O) (9 min) then 100% CH3CN (0.5 min). 'H NMR (400 MHz, CD3OD): 5 = 8.69 (s, 1H), 7.95 (d, 1H, J = 9.0 Hz), 7.70 (d, 1H, J= 7.8 Hz), 7.58 (d, 2H, J = 7.7 Hz), 7.32 (t, 2H, J = 7.9 Hz), 7.24 (d, 1H, J= 2.1 Hz), 7.11 (d, 1H, J = 7.8 Hz), 7.0-7.1 (m, 1H), 6.92 (dd, 1H, J= 2.1, 9.1 Hz), 5.05 (q, 1H, J= 6.4 Hz), 4.21 (t, 2H, J= 5.4 Hz), 3.7-3.8

(m, 4H), 2.85 (t, 2H, J= 5.4 Hz), 2.6-2.7 (m, 4H), 1.60 (d, 3H, J= 6.5 Hz). LC-MS: m/z = 460.4 [M+H] ⁺ , ESI pos. Example 62 l-[6-[5-(2-Morpholinoethoxy)benzimidazol-l-yl]-2-[3-(trifluo romethyl)pyrazol-l-yl]-3- pyridyl] ethanol

Step 1 : l-[ 6-chloro-2-[ 3-( trifluoromethyl)pyrazol-l-yl ]-3-pyridyl ] ethanone

Following the procedure described in step 1 of example 64, with 3-(trifluoromethyl)pyrazole (400 mg, 2.94 mmol, 1.02 equiv.), the title compound (650 mg, 74% yield) was obtained as a light yellow solid. LC-MS: m/z = 290.1 [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, CDCI3): 8 = 8.55 - 8.49 (m, 1H), 7.80 - 7.73 (m, 1H), 7.42 - 7.36 (m, 1H), 6.79 - 6.73 (m, 1H), 2.41 - 2.35 (m, 3H).

Step 2: l-[ 6-[ 4-(2-morpholinoethoxy)-2-nitro-anilino ]-2-[ 3-(trifluoromethyl)pyrazol-l-yl J-3- pyridyl ethanone

Following the procedure described in step 1 of example 53 (reaction time 16 h, temperature 90 °C), the title compound (210 mg, 31.3% yield) was obtained as a red gum. LC-MS: m/z = 521.2 [M+H] ⁺ , ESI pos.

Purification by preparative HPLC: column Phenom enex Gemini -NX C18 (75mm x 30mm x 3pm). Flow rate 25 mL / min. Gradient: 36% to 66% CH3CN in (10 mM NH4HCO3 in H2O) (10 min) then 100% CH3CN (0.5 min). Step 3: l-[ 6-[ 2-amino-4-(2-morpholinoethoxy)anilino ]-2-[ 3-(trifluoromethyl)pyrazol-l-yl ]-3- pyridyl ethanone

To a mixture of l-[6-[4-(2-morpholinoethoxy)-2-nitro-anilino]-2-[3-(trifluor omethyl)pyrazol-l- yl]-3-pyridyl]ethanone (200 mg, 0.38 mmol, 1 equiv.) and NH4CI (205 mg, 3.83 mmol, 9.97 equiv.) in EtOH (10 mL) and H2O (3 mL) was added Fe (108 mg, 1.93 mmol, 5.03 equiv.) in three portions at 20 °C. When the addition of Fe was complete, the resulting mixture was stirred at 50 °C for 16 hours. The black mixture was cooled to RT and filtered. The filtrate was concentrated and the residue was dissolved in 10 mL of CH3CN. The resulting suspension was filtered. The filtrate was concentrated to give the title compound (180 mg, 95.5% yield) as a yellow solid. LC-MS: m/z = 491.2 [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, CDCI3): 5 = 8.31 - 8.26 (m, 1H), 7.76 - 7.70 (m, 1H), 7.10 - 7.04 (m, 1H), 6.78 - 6.72 (m, 1H), 6.43 - 6.41 (m, 1H), 6.36 - 6.29 (m, 3H), 4.59 - 4.45 (m, 2H), 4.22 - 4.02 (m, 4H), 3.49 - 2.92 (m, 6H), 2.16 - 2.10 (m, 3H).

Step 4: l-[6-[5-(2-morpholinoethoxy)benzimidazol-l-yl]-2-[3-(trifluo romethyl)pyrazol-l-yl]-3- pyridyl ethanone

To a solution of l-[6-[2-amino-4-(2-morpholinoethoxy)anilino]-2-[3-(trifluoro methyl)pyrazol-l- yl]-3-pyridyl]ethanone (180 mg, 0.37 mmol, 1 equiv.) in EtOH (5 mL) were added trimethoxymethane (389 mg, 3.67 mmol, 10 equiv.) and p-toluenesulfonic acid (6 mg, 0.040 mmol, 0.1 equiv.). The reaction mixture was stirred at 80 °C for 1 hour. The mixture was then cooled to RT and concentrated in vacuo. The residue was taken in DCM (20 mL) and washed with sat. aq. NaHCOs. Sol. (20 mL). The organic layer was concentrated to dryness to afford the crude title compound (120 mg, 65.3% yield) as a light yellow solid. LC-MS: m/z = 501.2 [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, CDCI3): 8 = 8.53 - 8.50 (m, 1H), 8.50 - 8.47 (m, 1H), 8.01 - 7.98 (m, 1H), 7.95 - 7.91 (m, 1H), 7.56 - 7.50 (m, 1H), 7.32 - 7.28 (m, 1H), 7.05 - 7.01 (m, 1H), 6.79 - 6.76 (m, 1H), 4.70 - 4.30 (m, 2H), 4.04 - 3.73 (m, 4H), 3.37 - 2.77 (m, 6H), 2.36 - 2.31 (m, 3H).

Step 5: l-[6-[5-(2-morpholinoethoxy)benzimidazol-l-yl]-2-[3-(trifluo romethyl)pyrazol-l-yl]-3- pyridyl ethanol l-[6-[5-(2-morpholinoethoxy)benzimidazol-l-yl]-2-[3-(trifluo romethyl)pyrazol-l-yl]-3- pyridyl] ethanone (50 mg, 0.1 mmol, 1 equiv.) was dissolved in DCM (1 mL) with stirring at 20 °C. MeOH (0.5 mL) was added. The mixture was cooled to 0 °C. NaBLL (15 mg, 0.4 mmol, 4 equiv.) was added protion-wise. The resulting mixture was stirred at 5 °C for 1 hour. The mixture was quenched by the addition of 5 drops of sat. aq. NH4CI sol., then formic acid was added until pH 7 was reached. The mixture was concentrated under reduced pressure. The residue was purified by preparative HPLC: column Phenom enex Gemini -NX Cl 8 (75mm x 30mm x 3pm). Flow rate 30 mL / min. Gradient: 28% to 58% CH3CN in (10 mM NH4HCO3 in H2O) (8 min) then 100% CH3CN (2 min). The title compound (9.5 mg, 17.8% yield) was obtained as a colorless gum. LC-MS: m/z = 503.2 [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, CD3OD): 5 = 8.96 - 8.85 (m, 1H), 8.63 - 8.59 (m, 1H), 8.53 - 8.49 (m, 1H), 8.14 - 8.10 (m, 1H), 7.99 - 7.95 (m, 1H), 7.30 - 7.27 (m, 1H), 7.12 - 7.07 (m, 1H), 6.96 - 6.92 (m, 1H), 5.56 - 5.48 (m, 1H), 4.25 - 4.19 (m, 2H), 3.78 - 3.70 (m, 4H), 2.90 - 2.83 (m, 2H), 2.70 - 2.58 (m, 4H), 1.54 - 1.45 (m, 3H). Example 63 l-[6-(5,6-Dimethoxybenzimidazol-l-yl)-2-[3-(trifluoromethyl) pyrazol-l-yl]-3- pyridyl] ethanol Step 1: l-[6-(5,6-dimethoxybenzimidazol-l-yl)-2-[3-(trifluoromethyl) pyrazol-l-yl]-3- pyridyl ] ethanone

To a solution of l-[6-chloro-2-[3-(trifluoromethyl)pyrazol-l-yl]-3-pyridyl]et hanone (obtained as in step 1 of example 62) (100 mg, 0.35 mmol, 1 equiv.) and 5,6-dimethoxy-lH-benzimidazole (62 mg, 0.35 mmol, 1 equiv. )in CH3CN (5 mL) were added CS2CO3 (225 mg, 0.69 mmol, 2 equiv.) and CsF (10 mg, 0.07 mmol, 0.19 equiv.). The mixture was degassed and purged with N2 (three times). The mixture was then stirred at 70 °C for 16 h under N2 atomosphere. The mixture then was cooled to 20 °C and filtered. The filtrate was purified directly purified by preparative HPLC: column Phenomenex Gemini-NX C18 (75mm x 30mm x 3pm). Flow rate 30 mL / min. Gradient: 28% to 58% CH3CN in (10 mM NH4HCO3 in H ₂ O) (8 min) then 100% CH3CN (2 min). The title compound (25 mg, 12.6% yield) was obtained as light yellow solid. LC-MS: m/z = 431.1 [M+H] ⁺ , ESI pos. Step 2: l-[6-(5,6-dimethoxybenzimidazol-l-yl)-2-[3-(trifluoromethyl) pyrazol-l-yl]-3- pyridyl ethanol

Following the procedure described in step 5 of example 62, the title compound (8.5 mg, 39.7% yield) was obtained as a light yellow solid. Purification by preparative HPLC: column Phenomenex Gemini-NX C18 (75mm x 30mm x 3pm). Flow rate 30 mL / min. Gradient: 28% to 58% CH ₃ CN in (10 mM NH4HCO3 in H ₂ O) (8 min) then 100 % CH3CN (2 min). LC-MS: m/z = 434.1 [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, CD3OD): 5 = 8.82 - 8.77 (m, 1H), 8.67 - 8.61 (m, 1H), 8.54 - 8.47 (m, 1H), 8.04 - 7.97 (m, 1H), 7.93 - 7.89 (m, 1H), 7.30 - 7.26 (m, 1H), 6.99 - 6.93 (m, 1H), 5.55 - 5.45 (m, 1H), 3.95 - 3.87 (m, 6H), 1.54 - 1.47 (m, 3H).

Example 64

1- [3-(l-Hydroxyethyl)-6- [5- [(6-methylpyridazin-3-yl)amino] benzimidazol-l-yl]-2-pyridyl]- 5-methyl-pyrazole-3-carbonitrile

Intermediate 1 : N-( 6-methylpyridazin-3-yl)-lH-benzimidazol-5-amine

A mixture of 5-aminobenzimidazole (8.0 g, 60.1 mmol, 1.0 equiv.) and 3-chloro-6- methylpyridazine (7.34 g, 57.08 mmol, 0.950 equiv.) in PrOH (120 mL) was stirred at 120 °C for 72 hours. The dark brown suspension was concentrated in vacuo and the residue was triturated in MeOH (60 mL). The solid was collected by filtration and it was triturated in DCM (40 mL). The product was collected by filtration, washed with DCM and dried. The title compound (10 g, 71.3% yield) was obtained as brown solid. LC-MS: m/z = 226.0 [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, DMSO-t/6): 5 = 9.60 (br s, 1H), 8.72 (s, 1H), 8.52 (d, J = 1.7 Hz, 1H), 7.63 (d, J = 8.8 Hz, 1H), 7.44 (dd, J = 2.0, 8.8 Hz, 1H), 7.39 (d, J = 9.2 Hz, 1H), 7.21 (d, J = 9.2 Hz, 1H), 5.04 - 4.15 (m, 1H), 2.49 (s, 3H).

Step 1 : l-(3-acetyl-6-chloro-2-pyridyl)-5-methyl-pyrazole-3-carbonit rile

A solution of l-(6-chloro-2-fluoro-3-pyridyl)ethanone (CAS# 1260663-13-5, 5 g, 28.81 mmol, 1 equiv.), 5-methyl-lH-pyrazole-3-carbonitrile (2.93 g, 27.37 mmol, 0.950 equiv.) and DIPEA (14.3 mL, 86.42 mmol, 3 equiv.) in DMSO (50 mL) was stirred at 80 °C for 4 hours. The reaction mixture was cooled to RT, poured into H2O (250 mL) and extracted with EtOAc (3 x 150 mL). The combined organic layers were washed with brine (3 x 300mL) and concentrated in vacuo. The residue was purified by flash chromatography (silica gel, 0% to 35% EtOAc in petroleum ether). The title compound (5.3 g, 70.6% yield) was obtained as yellow oil. LC-MS: m/z = 261.1 [M+H] ⁺ , ESI pos.

Step 2: l-[ 3-acetyl-6-[5-[ ( 6-methylpyridazin-3-yl)amino ]benzimidazol-l-yl ]-2-pyridyl -5- methyl-pyrazole-3-carbonitrile and l-[ 3-acetyl-6-[ 6-[ ( 6-methylpyridazin-3- yl)amino ]benzimidazol-l-yl / -2 -pyridyl ]-5-methyl-pyrazole-3-carbonitrile

A mixture of l-(3-acetyl-6-chloro-2-pyridyl)-5-methyl-pyrazole-3-carbonit rile (5.3 g, 20.33 mmol, 1 equiv.), N-(6-methylpyridazin-3-yl)-lH-benzimidazol-5-amine (intermediate 1) (4.58 g, 20.33 mmol, 1 equiv.) and K2CO3 (5.62 g, 40.66 mmol, 2 equiv.) in DMSO (50 mL) was stirred at 50 °C for 12 hours. The mixture was cooled to RT and poured into H2O (500 mL). A solid precipitated out. This was extracted with EtOAc (3 x 400 mL). The combined organic layers were concentrated. The residue was purified by preparative HPLC: column Phenom enex Luna C18 (250mm x 70 mm x 15pm. Flow rate 140 mL / min. Gradient: 20% to 50% CH3CN in (H2O with 0.225% formic acid v/v) (35 min) then 100% CH3CN (1 min). A mixture of the 2 title compounds was obtained. This mixture was purified by preparative NPLC: column Welch Ultimate XB-SiOH (250mm x 70mm x lOum). Flow rate 140 mL / min. Gradient: 20% to 60% EtOH in hexane (20 min) then 100% EtOH (3 min) to yield l-[3-acetyl-6-[6-[(6- methylpyridazin-3-yl)amino]benzimidazol-l-yl]-2-pyridyl]-5-m ethyl-pyrazole-3-carbonitrile (1.1 g, 12% yield) as a light brown solid and l-[3-acetyl-6-[5-[(6-methylpyridazin-3- yl)amino]benzimidazol-l-yl]-2-pyridyl]-5-methyl-pyrazole-3-c arbonitrile (600 mg, 6.6% yield) as light brown solid. Regioisomer 1 : LC-MS: m/z = 450.1 [M+H] ⁺ , ESI pos. ^J H NMR (400 MHz, DMSO-t/e) 5 = 9.31 (s, 1H), 9.01 (s, 1H), 8.98 (d, J= 2.0 Hz, 1H), 8.55 (d, J = 8.4 Hz, 1H), 8.27 (d, J= 8.4 Hz, 1H), 7.70 (d, J= 8.7 Hz, 1H), 7.46 (dd, J= 2.0, 8.7 Hz, 1H), 7.30 (d, J = 9.0 Hz, 1H), 7.09 - 7.04 (m, 2H), 2.55 (s, 3H), 2.50 (br s, 3H), 2.19 (s, 3H). Regioisomer 2: LC-MS: m/z = 450.1 [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, DMSO-t/ ₆ ) 6 = 9.30 (s, 1H), 9.11 (s, 1H), 8.54 (d, J = 8.4 Hz, 1H), 8.47 (d, J= 1.7 Hz, 1H), 8.30 (d, J= 8.6 Hz, 1H), 8.14 (d, J = 8.9 Hz, 1H), 7.53 (dd, J= 1.9, 8.9 Hz, 1H), 7.34 (d, J = 9.0 Hz, 1H), 7.14 (s, 1H), 7.10 (d, J = 9.0 Hz, 1H), 2.54 (s, 3H), 2.48 (br s, 3H), 2.20 (s, 3H).

Step 3: l-[ 3-( 1 -hydroxyethyl)-6-[5-[ ( 6-methylpyridazin-3-yl)amino ]benzimidazol-l-yl -2- pyridyl]-5-methyl-pyrazole-3-carbonitrile

To a solution of l-[3-acetyl-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol -l-yl]-2-pyridyl]- 5-methyl-pyrazole-3-carbonitrile (600 mg, 1.33 mmol, 1 equiv.) in a mixture of MeOH (10 mL) and THF (10 mL) was added NaBLL (151 mg, 3.99 mmol, 2.99 equiv.) at 0 °C. Stirring at 0 °C was continued for 1 hour. DMF (5 mL) was added to the mixture which was stirred at 20 °C for 2 hours. The mixture was cooled again to 0 °C and NaBJLj (76 mg, 2 mmol, 1.5 equiv.) was added. The cooling bath was removed and stirring at RT was continued for 2 hours. The reaction mixture was quenched by the slow addition of H2O (50 mL) and then extracted with DCM (2 x 50 mL). The combined organic extracts were concentrated under vacuum. The residue was purified by preparative HPLC: column Waters Xbridge (150mm x 25mm x 5pm). Flow rate 60 mL / min. Gradient: 19% to 49% CH3CN in (10 mM NH4HCO3 in H2O) (11 min) then 100 % CH3CN (2 min). The title compound (400 mg, 65% yield) was obtained as a white liophilized solid. LC-MS: m/z = 452.2 [M+H] ⁺ , ESI pos.

Example 65 l-[3-(l-Hydroxyethyl)-6-[5-(4-methylpiperazin-l-yl)benzimida zol-l-yl]-2-pyridyl]-5- methyl-pyrazole-3-carbonitrile

Step 1: l-[3-acetyl-6-(5-bromobenzimidazol-l-yl)-2-pyridyl]-5-methyl -pyrazole-3-carbonitrile and l-[ 3-acetyl-6-( 6-bromobenzimidazol-l-yl)-2 -pyridyl ]-5-methyl-pyrazole-3-carbonitrile

To a solution of 5-bromo-lH-benzimidazole (1.51 g, 7.67 mmol, 1 equiv.) in DMSO (15 mL) were added l-(3-acetyl-6-chloro-2-pyridyl)-5-methyl-pyrazole-3-carbonit rile (obtained as in step 1 of example 64) (2.0 g, 7.67 mmol, 1 equiv.) and K^CCh (1.51 g, 15.34 mmol, 2 equiv.) . The mixture was stirred at 60 °C for 2 hours. The reaction mixture was cooled to RT, poured into H2O (100 mL) and extracted with EtOAc (3 x 100 mL). The combined organic layers were washed with brine (3 x 100 mL) and concentrated under vacuum. The residue was purified by flash chromatography (20% to 100% EtOAc in petroleum ether) to give a mixture of both title compounds. This mixture was purified by preparative HPLC: column Phenomenex Luna C18 (150mm x 40mm x 15pm). Flow rate: 60 mL / min. Gradient: 53% to 63% CH3CN in (H2O with 0.225% formic acid v/v) (10 min) then 100% CH3CN (2 min) to yield l-[3-acetyl-6-(5- bromobenzimidazol-l-yl)-2-pyridyl]-5-methyl-pyrazole-3-carbo nitrile (750 mg, 23.2% yield) as a light yelow liophilized solid and compound l-[3-acetyl-6-(6-bromobenzimidazol-l-yl)-2- pyridyl]-5-methyl-pyrazole-3-carbonitrile (400 mg, 12.4% yield) as a light yellow lyophilized solid. Regioisomer 1 : LC-MS: m/z = 421.0 [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, CDC1 ₃ ) 8 = 8.60 (s, 1H), 8.32 (d, J= 8.3 Hz, 1H), 8.25 (s, 1H), 7.81 - 7.73 (m, 2H), 7.56 (dd, J= 1.6, 8.4 Hz, 1H), 6.74 (s, 1H), 2.67 (s, 3H), 2.25 (s, 3H). Regioisomer 2: LC-MS: m/z = 421.0 [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, CDCI3) 6 = 8.67 - 8.52 (m, 1H), 8.22 (d, J = 8.3 Hz, 1H), 8.00 (br s, 1H), 7.90 (br d, J= 5.0 Hz, 1H), 7.66 (d, J= 8.3 Hz, 1H), 7.46 (d, J= 8.8 Hz, 1H), 6.64 (s, 1H), 2.53 (s, 3H), 2.15 (s, 3H).

Step 2: l-[3-acetyl-6-[5-(4-methylpiperazin-l-yl)benzimidazol-l-yl]- 2-pyridyl]-5-methyl- pyrazole-3-carbonitrile

To a solution of 1 -methylpiperazine (71 mg, 0.710 mmol, 2 equiv.) in 1,4-dioxane (5 mL) were added l-[3-acetyl-6-(5-bromobenzimidazol-l-yl)-2-pyridyl]-5-methyl -pyrazole-3-carbonitrile (150 mg, 0.36 mmol, 1 equiv.), CS2CO3 (348 mg, 1.07 mmol, 3 equiv.) and t-Buxphos-Pd-G3 (CAS # 1447963-75-8) (28 mg, 0.04 mmol, 0.1 equiv.). The grey suspension was stirred at 90 °C for 4 h under N2 atmosphere. The reaction mixture was cooled to RT, poured into H2O (20 mL) and extracted with EtOAc (2 x 30 mL). The combined extracts were concentrated under vacuum. The residue was purified by preparative TLC (silica gel, 20% MeOH in DCM, UV detection). The title compound (30 mg, 19.1% yield) was obtained as a yellow solid. LC-MS: m/z = 441.3 [M+H] ⁺ , ESI pos. Step 3: l-[3-(l-hydroxyethyl)-6-[5-(4-methylpiperazin-l-yl)benzimida zol-l-yl]-2-pyridyl]-5- methyl-pyrazole-3-carbonitrile

To a stirred solution of l-[3-acetyl-6-[5-(4-methylpiperazin-l-yl)benzimidazol-l-yl]- 2-pyridyl]- 5-methyl-pyrazole-3-carbonitrile (30 mg, 0.07 mmol, 1 equiv.) in a mixture of MeOH (0.5 mL) and THF (0.5 mL)was added NaBTLj (8 mg, 0.2 mmol, 3 equiv.) at 0 °C. Stirring at 0 °C was continued for 1 hour. The reaction mixture was quenched by the addition of H2O (10 mL). DCM (10 mL) was added to the reaction mixture. The aqueous phase was back-extracted with DCM (2 x 10 mL). The combined organic extracts were concentrated under vacuum. The residue was purified by prep-HPLC: column Waters Xbridge (150mm x 25mm x 5pm). Flow rate: 25 mL / min. Gradient: 25% to 55% CH3CN in (lOmM NH4HCO3 in H ₂ O) (10 min) then 100% CH3CN (2 mmin). The title compound (4 mg, 13.2% yield) was obtained as a white lyophilized solid. LC-MS: m/z = 443.2 [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, CD3OD): 5 = 8.85 (s, 1H), 8.48 (d, J= 8.4 Hz, 1H), 8.11 (d, J= 8.6 Hz, 1H), 8.05 (d, J= 9.2 Hz, 1H), 7.28 (d, J= 2.1 Hz, 1H), 7.17 (dd, J = 2.1, 9.1 Hz, 1H), 6.86 (s, 1H), 4.76 (q, J = 6.6 Hz, 1H), 3.27 - 3.22 (m, 4H), 2.69 - 2.63 (m, 4H), 2.38 (d, J= 10.0 Hz, 6H), 1.40 (d, J= 6.4 Hz, 3H).

Example 67 l-[3-(l-Hydroxyethyl)-6-[5-[4-(oxetan-3-yl)piperazin-l-yl]be nzimidazol-l-yl]-2-pyridyl]-5- methyl-pyrazole-3-carbonitrile Step 1 : l-[ 3-acetyl-6-[5-[ 4-(oxetan-3-yl)piperazin-l-yl ]benzimidazol-l-yl / -2 -pyridyl ]-5-methyl- pyrazole-3-carbonitrile

Following the procedure described in step 2 of example 65, starting with l-(oxetan-3- yl)piperazine (101 mg, 0.71 mmol, 2 equiv.) and using H2O (0.06 mL, 3.56 mmol, 10 equiv.) as additional reagent, the title compound (40 mg, 23.3% yield) was obtained as a yellow oil. LC- MS: m/z = 473.2 [M+H] ⁺ , ESI pos.

Step 2: l-[ 3-( I -hydroxyethyl)-6-[5-[ 4-(oxetan-3-yl)piperazin-l-yl ]benzimidazol-l-yl -2- pyridyl]-5-methyl-pyrazole-3-carbonitrile

Following the procedure described in step 3 of example 65, at a temperature of -40 °C and a reaction time of 30 min, the title compound (15.6 mg, 38.1% yield) was obtained as a white lyophilized solid. LC-MS: m/z = 485.2 [M+H] ⁺ , ESI pos.

Purification by preparative HPLC: column Pheomenex Gemini-NX C18 (75mm x 30mm x 3pm). Flow rate: 30 mL / min. Gradient: 15% to 45% CH3CN in (lOmM NH4HCO3 in H2O) (8 min) then 100% CH3CN (2 min). 'H NMR (400 MHz, CD3OD): 5 = 8.83 (s, 1H), 8.47 (d, J = 8.6 Hz, 1H), 8.11 - 8.00 (m, 2H), 7.26 (d, J= 2.1 Hz, 1H), 7.14 (dd, J= 2.1, 9.1 Hz, 1H), 6.85 (s, 1H), 4.79 - 4.70 (m, 3H), 4.67 - 4.62 (m, 2H), 3.57 (quin, J = 6.4 Hz, 1H), 3.24 (br s, 4H), 2.55 (br s, 4H), 2.38 (s, 3H), 1.40 (d, J= 6.5 Hz, 3H). Example 68 l-[3-(l-Hydroxyethyl)-6-[5-(2-morpholinoethoxy)benzimidazol- l-yl]-2-pyridyl]-5-methyl- pyrazole-3-carbonitrile Step 1: l-[3-acetyl-6-[5-(2-morpholinoethoxy)benzimidazol-l-yl]-2-py ridyl]-5-methyl-pyrazole- 3-carbonitrile

Starting with of 2-morpholinoethanol (124 mg, 0.95 mmol, 2 equiv.) and following the procedure described in step 2 of example 65, the title compound (30 mg, 13.4% yield) was obtained as yellow oil. LC-MS: m/z = 472.3 [M+H] ⁺ , ESI pos.

Step 2: l-[ 3-( 1 -hydroxyethyl)-6-[5-(2-morpholinoethoxy)benzimidazol-l-yl ]-2-pyridyl -5- methyl-pyrazole-3-carbonitrile

Following the procedure described in step 3 of example 65, at -40 °C for 2 h, then at -10 °C for 10 min, the title compound (6.8 mg, 22.6% yield) was obtained as a white lyophilized solid. LC-

MS: m/z = 474.3 [M+H] ⁺ , ESI pos. Purification by preparative HPLC: column Waters Xbridge (150mm x 25mm x 5pm). Flow rate: 25 mL / min. Gradient: 28% to 58% CH3CN in (lOmM NH4HCO3 in H ₂ O) (10 min) then 100% CH3CN (2 min). 'H NMR (400 MHz, CD3OD): 5 = 8.88 (s, 1H), 8.49 (d, J = 8.5 Hz, 1H), 8.12 (d, J = 8.5 Hz, 1H), 8.07 (d, J = 9.0 Hz, 1H), 7.29 (d, J= 2.1 Hz, 1H), 7.07 (dd, J= 1.8, 8.9 Hz, 1H), 6.86 (s, 1H), 4.76 (q, J= 6.4 Hz, 1H), 4.22 (t, J= 5.4 Hz, 2H), 3.75 - 3.70 (m, 4H), 2.85 (t, J= 5.4 Hz, 2H), 2.66 - 2.59 (m, 4H), 2.39 (s, 3H), 1.40 (d, J= 6.4 Hz, 3H).

Example 71 l-[3-(l-Hydroxyethyl)-6-[5-[[l-(oxetan-3-yl)pyrazol-4-yl]ami no]benzimidazol-l-yl]-2- pyridyl]-5-methyl-pyrazole-3-carbonitrile

Step 1: l-[6-(5-bromobenzimidazol-l-yl)-3-(l-hydroxyethyl)-2-pyridyl ]-5-methyl-pyrazole-3- carbonitrile

Starting from l-[3-acetyl-6-(5-bromobenzimidazol-l-yl)-2-pyridyl]-5-methyl -pyrazole-3- carbonitrile (obtained as in step 1 of example 65) (750 mg, 1.78 mmol, 1 equiv.) and following the procedure described in step 3 of example 65, the crude (after extraction work-up) title compound (750 mg, 99.5% yield) was obtained as an off-white solid. LC-MS: m/z = 425.0 [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, CDC1 ₃ ): 8 = 8.50 (s, 1H), 8.32 (d, J = 8.4 Hz, 1H), 7.96 (d, J= 1.8 Hz, 1H), 7.82 (d, J = 8.8 Hz, 1H), 7.69 (d, J = 8.4 Hz, 1H), 7.44 (dd, J= 1.8, 8.8 Hz, 1H), 6.64 (s, 1H), 4.81 (q, J= 6.5 Hz, 1H), 2.42 - 2.39 (m, 3H), 1.45 (d, J= 6.5 Hz, 3H). Step 2: l-[ 3-( 1 -hydroxyethyl)-6-[5-[[ l-(oxetan-3-yl)pyrazol-4-yl ] amino ]benzimidazol-l-yl ]-2- pyridyl]-5-methyl-pyrazole-3-carbonitrile

To a solution of l-[6-(5-bromobenzimidazol-l-yl)-3-(l-hydroxyethyl)-2-pyridyl ]-5-methyl- pyrazole-3 -carbonitrile (100 mg, 0.24 mmol, 1 equiv.) in 1,4-dioxane (5 mL) were added l-(3- oxetanyl)-lH-pyrazol-4-amine (39 mg, 0.280 mmol, 1.2 equiv.), CS2CO3 (154 mg, 0.47 mmol, 2 equiv.) and RuPhos-Pd-G3 (20 mg, 0.02 mmol, 0.1 equiv.). The reaction mixture was stirred for 4 hours at 100 °C under N2 atmosphere. The mixture was cooled to RT, diluted with MeOH (20 mL), treated with thiourea resin and stirred at RT for 16 hours. The mixture was filtered and the filtrate was concentrated to dryness. The residue was purified by preparative HPLC: column Phenomenex Luna C18 (150mm x 25mm x 10pm). Flow rate: 25 mL / min. Gradient: 16% to 46% CH3CN in (0.225% formic acid in H2O v/v) (10 min) then 100% CH3CN (2 min). The title compound (57.1 mg, 45.2% yield) was obtained as an off-white lyophilized solid. LC-MS: m/z = 482.2 [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, CD3OD): 5 = 8.79 (s, 1H), 8.46 (d, J = 8.5 Hz, 1H), 8.09 (d, J= 8.5 Hz, 1H), 7.96 (d, J= 8.9 Hz, 1H), 7.78 (s, 1H), 7.54 (s, 1H), 7.14 (d, J= 2.1 Hz, 1H), 6.96 (dd, J = 2.3, 8.9 Hz, 1H), 6.85 (d, J= 0.6 Hz, 1H), 5.52 (quin, J = 6.9 Hz, 1H), 5.05 (d, J= 6.9 Hz, 4H), 4.75 (q, J= 6.4 Hz, 1H), 2.39 (s, 3H), 1.40 (d, J= 6.5 Hz, 3H).

Example 72

1- [6- [5- [ [l-(Azetidin-3-yl)pyrazol-4-yl] amino] benzimidazol- 1-yl] -3-(l-hydroxyethyl)-2- pyridyl]-5-methyl-pyrazole-3-carbonitrile Step 1: tert-butyl 3-[4-[[l-[6-(3-cyano-5-methyl-pyrazol-l-yl)-5-(l-hydroxyethy l)-2- pyridyl ]benzimidazol-5-yl amino ]pyrazol-l-yl azetidine- 1 -carboxylate

To a solution of l-[6-(5-bromobenzimidazol-l-yl)-3-(l-hydroxyethyl)-2-pyridyl ]-5-methyl- pyrazole-3 -carbonitrile (140 mg, 0.33 mmol, 1 equiv.) in 1,4-dioxane (5 mL) were added tertbutyl 3 -(4-aminopyrazol-l-yl)azetidine-l -carboxylate (95 mg, 0.4 mmol, 1.2 equiv.), CS2CO3 (216 mg, 0.66 mmol, 2 equiv.) and RuPhos-Pd-G3 (28 mg, 0.03 mmol, 0.1 equiv.). The reaction mixture was heated to 100 °C and stirred for 4 hours under N2 atmosphere. The reaction mixture was poured into H2O (50 mL) and extracted with EtOAc (3 x 50 mL). The combined organics were washed with brine (2 x 50 mL) and concentrated in vacuo. The residue was purified by preparative TLC (silica gel, 10% MeOH in DCM, UV detection). The title compound (150 mg, 78.1% yield) was obtained as a brown oil. LC-MS: m/z = 581.4 [M+H] ⁺ , ESI pos.

Step 2: l-[ 6-[5-[[l -(azetidin-3-yl)pyrazol-4-yl amino ]benzimidazol-l-yl ]-3-( I -hydroxyethyl)-2- pyridyl]-5-methyl-pyrazole-3-carbonitrile

To a solution of tert-butyl 3-[4-[[l-[6-(3-cyano-5-methyl-pyrazol-l-yl)-5-(l-hydroxyethy l)-2- pyridyl]benzimidazol-5-yl]amino]pyrazol-l-yl]azetidine-l-car boxylate (140 mg, 0.24 mmol, 1 equiv.) in DCM (2 mL) was added HC1 in 1,4-dioxane (2.0 mL, 8 mmol, 33.18 equiv.). The reaction mixture was stirred at 30 °C for 2 hours. The reaction mixture was concentrated under reduced pressure and the residue was purified by preparative HPLC: column Phenom enex Luna C18 (150mm x 25mm x 10pm). Flow rate: 25 mL / min. Gradient: 6% to 36% CH3CN in (0.225% formic acid in H2O v/v) (10 min) then 100% CH3CN (2 min). The title compound (27.9 mg, 22.9% yield) was obtained as a white lyophilized solid. LC-MS: m/z = 481.2 [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, DMSO-t/ ₆ ): 8 = 8.93 (s, 1H), 8.42 (d, J = 8.6 Hz, 1H), 8.32 (s, 1H), 8.23 (d, J= 8.4 Hz, 1H), 7.94 - 7.88 (m, 2H), 7.68 (s, 1H), 7.46 (s, 1H), 7.10 (s, 2H), 6.91 (dd, J = 1.9, 8.8 Hz, 1H), 5.26 - 5.16 (m, 1H), 4.55 (q, J= 6.4 Hz, 1H), 4.10 - 4.04 (m, 2H), 3.92 (br t, J= 8.3 Hz, 2H), 2.34 (s, 3H), 1.26 (br d, J= 6.4 Hz, 3H).

Example 74 l-[3-(l-Hydroxyethyl)-6-[6-(6-methylpyridazin-3-yl)oxybenzim idazol-l-yl]-2-pyridyl]-5- methyl-pyrazole-3-carbonitrile

Step 1: l-(2-trimethylsilylethoxymethyl)benzimidazol-5-ol

A mixture of lH-benzimidazol-5-ol (1.0 g, 7.45 mmol, 1 equiv.), 2-(trimethylsilyl)ethoxym ethyl chloride (1.98 mL, 11.18 mmol, 1.5 equiv.) and DIPEA (1.93 g, 14.91 mmol, 2 equiv.) in DCM (30 mL) was stirred at 0 °C for 10 minutes, and then at 40 °C for 16 hours. More 2- (trimethylsilyl)ethoxymethyl chloride (0.66 mL, 3.73 mmol, 0.5 equiv.) was added and stirring at 40 °C was continued for 12 hours. The reaction mixture was cooled to RT, quenched with H2O (150 mL) and extracted with DCM (3 x 50 mL). The combined organic layers were dried over Na2SO4, filtered and concentrated under reduced pressure. The residue was purified by flash chromatography (silica gel, 10% MeOH in DCM). The title compound (600 mg, 30.4% yield) was obtained as a yellow oil. LC-MS: m/z = 265.1 [M+H] ⁺ , ESI pos.

Step 2: trimethyl- [ 2-[ [5-( 6-methylpyridazin-3-yl)oxybenzimidazol-l-yl / methoxy ] ethyl ] silane A mixture of l-(2-trimethylsilylethoxymethyl)benzimidazol-5-ol (0.6 g, 2.27 mmol, 1 equiv.), 3- chloro-6-methylpyridazine (292 mg, 2.27 mmol, 1 equiv.) and K2CO3 (0.63 g, 4.54 mmol, 2 equiv.) in DMF (10 mL) was sirred at 140 °C for 12 hours. The mixture was cooled to RT, quenched with H2O (100 mL) and extracted with EtOAc (3 x 50 mL). The combined organic layers were washed with brine (3 x 30 mL), dried over Na2SO4, filtered and concentrated under reduced pressure. The residue which was purified by flash chromatography(silica gel, 10% MeOH in DCM. The title compound (800 mg, 79.1% yield) was obtained as a brown oil. LC- MS: m/z = 357.1 [M+H] ⁺ , ESI pos.

Step 3: 5-(6-methylpyridazin-3-yl)oxy-lH-benzimidazole

A solution of trimethyl-[2-[[5-(6-methylpyridazin-3-yl)oxybenzimidazol-l- yl]methoxy]ethyl]silane (1.1 g, 3.09 mmol, 1 equiv.) in TFA (5 mL, 61.62 mmol, 19.97 equiv.) was stirred at 20 °C for 2 hours. The reaction mixture was quenched with H2O (10 mL) and extracted with EtOAc (3 x 10 mL). The aqueous layer was freeze-dried to give the title compound (900 mg, TFA salt) as a yellow gum. This product was taken in DCM (100 mL) and treated with K2CO3. Stirring at at 30 °C was continued for 2 hours. The mixture was filtered and the filtrate was concentrated. The residue was purified by preparative HPLC: column Waters Xbridge (150mm x 25mm x 5pm). Flow rate: 25 mL / min. Gradient: 1% to 33% CH3CN in (10 mM NH4HCO3 in H2O) (9 min) then 100% CH3CN (2 min). The title compound (520 mg, 74.5% yield) was obtained as a yellow lyophilized solid. LC-MS: m/z = 226.9 [M+H] ⁺ , ESI pos.

Step 4: l-[ 3-acetyl-6-[5-( 6-methylpyridazin-3-yl)oxybenzimidazol-l-yl ]-2-pyridyl ]-5-methyl- pyrazole-3-carbonitrile and l-[ 3-acetyl-6-[ 6-( 6-methylpyridazin-3-yl)oxybenzimidazol-l-yl -2- pyridyl]-5-methyl-pyrazole-3-carbonitrile

Following the procedure described in step 2 of example 64 and with a reaction time of 3 hours.

Purification by preparative HPLC: column Phenomenex Synergi C18 (150mm x 25mm x 10pm). Flow rate: 25 mL / min. Gradient: 30% to 60% CH3CN in (0.225% formic acid in H2O v/v) (8.5 min) then 100% CH3CN (2 min). Further purification by chiral SFC performed to separate the 2 regioisomers (Daicel Chiralpak AD (250mm x 30mm x 10pm), flow rate: 80 mL / min. 70% (0.1% NH4OH in MeOH) to yield l-[3-acetyl-6-[5-(6-methylpyridazin-3-yl)oxybenzimidazol-l- yl]-2-pyridyl]-5-methyl-pyrazole-3-carbonitrile (38 mg, 11% yield) as a white lyophilized solid and l-[3-acetyl-6-[6-(6-methylpyridazin-3-yl)oxybenzimidazol-l-y l]-2-pyridyl]-5-methyl- pyrazole-3 -carbonitrile (44 mg, 12.7% yield) as white lyophilized solid. Regioisomer 1 : LC-MS: m/z = 451.1 [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, CD3OD): 5 = 9.00 (s, 1H), 8.44 (d, J = 8.4 Hz, 1H), 8.17 - 8.06 (m, 2H), 7.82 (d, J = 8.7 Hz, 1H), 7.64 (d, J = 9.0 Hz, 1H), 7.35 (d, J= 9.0 Hz, 1H), 7.26 (dd, J = 2.3, 8.7 Hz, 1H), 6.81 (s, 1H), 2.63 (s, 3H), 2.47 (s, 3H), 2.19 (s, 3H). Regioisomer 2: LC-MS: m/z = 451.1 [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, CD3OD): 5 = 9.01 (s, 1H), 8.46 (d, J = 8.4 Hz, 1H), 8.25 (d, J = 8.9 Hz, 1H), 8.13 (d, J= 8.3 Hz, 1H), 7.64 (d, J = 9.2 Hz, 1H), 7.58 (d, J= 2.0 Hz, 1H), 7.35 (d, J = 9.0 Hz, 1H), 7.26 (dd, J= 1.7, 8.9 Hz, 1H), 6.88 (s, 1H), 2.61 (s, 3H), 2.57 (s, 3H), 2.22 (s, 3H).

Step 5: l-[ 3-( 1 -hydroxyethyl)-6-[ 6-( 6-methylpyridazin-3-yl)oxybenzimidazol-l-yl ]-2-pyridyl ]-5- methyl-pyrazole-3-carbonitrile

To a solution of l-[3-acetyl-6-[6-(6-methylpyridazin-3-yl)oxybenzimidazol-l-y l]-2-pyridyl]-5- methyl-pyrazole-3 -carbonitrile (10 mg, 0.02 mmol, 1 equiv.) in Methanol (3 mL) was added NaBH4 (2 mg, 0.05 mmol, 2.38 equiv.) at 0 °C . The mixture was stirred at 0 °C for 0.5 h and directly purified by preparative HPLC: column Phenomenex Synergi C18 (150mm x 25mm x 10pm). Flow rate: 25 mL / min. Gradient: 28% to 58% CH3CN in (0.225% formic acid in H2O v/v) (8.5 min) then 100% CH3CN (2 min). The title compound (7.6 mg, 75.2% yield) was obtained as a white lyophilized solid. LC-MS: m/z = 453.1 [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, CD3OD): 5 = 9.00 (s, 1H), 8.51 (d, J = 8.4 Hz, 1H), 8.16 (d, J= 8.5 Hz, 1H), 8.04 (d, J = 2.3 Hz, 1H), 7.84 (d, J = 8.8 Hz, 1H), 7.66 (d, J= 9.0 Hz, 1H), 7.37 (d, J= 9.0 Hz, 1H), 7.27 (dd, J= 2.3, 8.8 Hz, 1H), 6.80 (s, 1H), 4.81 - 4.73 (m, 2H), 2.66 (s, 3H), 2.32 (s, 3H), 1.40 (d, J = 6.5 Hz, 3H). Example 75 l-[3-(l-Hydroxyethyl)-6-[5-(6-methylpyridazin-3-yl)oxybenzim idazol-l-yl]-2-pyridyl]-5- methyl-pyrazole-3-carbonitrile

Starting from l-[3-acetyl-6-[5-(6-methylpyridazin-3-yl)oxybenzimidazol-l-y l]-2-pyridyl]-5- methyl-pyrazole-3 -carbonitrile (obtained as in step 4 of example 74) (38 mg, 0.08 mmol, 1 equiv.) and following the procedure described in step 5 of example 74, the title compound (25.3 mg, 66.3% yield) was obtained as a white lyophilized solid. Purification by preparative HPLC: column Phenomenex Synergi C18 (150mm x 25mm x 10pm). Flow rate: 25 mL / min. Gradient: 28% to 58% CH3CN in (0.225% formic acid in H2O v/v) (8.5 min) then 100% CH3CN (2 min). LC-MS: m/z = 453.1 [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, CD3OD): 5 = 9.00 (s, 1H), 8.53 (d, J= 8.4 Hz, 1H), 8.28 - 8.21 (m, 1H), 8.18 (d, J= 8.6 Hz, 1H), 7.64 (d, J= 9.0 Hz, 1H), 7.59 (d, J = 2.1 Hz, 1H), 7.35 (d, J= 92 Hz, 1H), 7.27 (br d, J= 8.3 Hz, 1H), 6.86 (s, 1H), 4.82 - 4.74 (m, 1H), 2.61 (s, 3H), 2.41 (s, 3H), 1.42 (d, J= 6.5 Hz, 3H).

Example 76

5- [3-(l-Hydroxyethyl)-6- [5- [(6-methylpyridazin-3-yl)amino] benzimidazol-l-yl]-2-pyridyl]- l-methyl-pyrazole-4-carbonitrile

Step 1: l-(2-chloro-6-fluoro-3-pyridyl)ethanone

A mixture of 3-bromo-2-chloro-6-fluoro-pyridine (5.0 g, 23.76 mmol, 1 equiv.), tributyl(l- ethoxyvinyl)tin (10.3 g, 28.51 mmol, 1.2 equiv.), K2CO3 (9.85 g, 71.28 mmol, 3 equiv.) and dichloropalladium triphenylphosphine (3.34 g, 4.75 mmol, 0.2 equiv.) in a mixture of 1,4- di oxane (80 mL) and H2O (5 mL) was stirred at 100 °C for 12 hours under N2 atmosphere. The reaction mixture was cooled to RT, poured into sat. aq. KF sol. (50 mL) and stirred for 2 hours. The mixture was then extracted with EtOAc (3 x 20 mL). The combined organic layers were treated with 2N HC1 (20 mL) and the mixture was stirred for 2 hours. Then the mixture was basified by the addition of aqueous ISfeCCL until pH 8 was reached. The layers were separated. The aqueous phase was extracted with EtOAc (2 x 20 mL). The combined organic layers were dried over Na2SO4, filtered and concentrated under vacuum. The residue was purified by flash chromatography (SiO2, 10 % EtOAc in petroleum ether). The title compound (1.9 g, 46.1% yield) was obtained as a yellow oil. 'H NMR (400 MHz, CDCI3): 5 = 8.13 (dd, J= 7.6, 8.3 Hz, 1H), 6.98 (dd, J= 3.3, 8.4 Hz, 1H), 2.72 (s, 3H).

Step 2: l-[2-chloro-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol -l-yl]-3- pyridyl ethanone

A solution of l-(2-chloro-6-fluoro-3-pyridyl)ethanone (1.9 g, 10.95 mmol, 1 equiv.), N,N- diisopropylethylamine (3.8 mL, 21.89 mmol, 2 equiv.) and N-(6-methylpyridazin-3-yl)-lH- benzimidazol-5-amine (obtained as in intermediate 1 of example 64) (2.47 g, 10.95 mmol, 1 equiv.) in DMSO (30 mL) was stirred at 60 °C for 12 hours. The reaction mixture was cooled to rt, poured into H2O (100 mL) and extracted with EtOAc (3 x 200 mL). The combined organic layers were dried over Na2SO4, filtered and concentrated under vacuum. The residue was purified by preparative NPLC: column Welch Ultimate XB-SiOH (250mm x 70mm x 10pm). Flow rate: 140 mL / min. Gradient: 10% to 50% EtOH in hexane (25 min) then 100% EtOH (4 min). The title compound (500 mg, 1.32 mmol, 12.1% yield) was obtained as a brown solid. LC- MS: m/z = 379.0 [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, DMSO-t/ ₆ ): 8 = 9.30 (br s, 1H), 9.08 (s, 1H), 8.49 - 8.44 (m, 2H), 8.30 (d, J = 8.9 Hz, 1H), 8.11 (s, 1H), 7.53 (dd, J= 2.1, 8.9 Hz, 1H), 7.35 (d, J= 9.1 Hz, 1H), 7.11 (d, J = 9.1 Hz, 1H), 2.68 (s, 3H), 2.49 (br s, 3H).

Step 3: 5-[ 3-acetyl-6-[5-[ ( 6-methylpyridazin-3-yl)amino ]benzimidazol-l-yl ]-2-pyridyl ]-l- methyl-pyrazole-4-carbonitrile

To a solution of l-[2-chloro-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol -l-yl]-3- pyridyl] ethanone (100 mg, 0.26 mmol, 1 equiv.) in 1,4-dioxane (6 mL) and H2O (0.3 mL) were added l-methyl-5-(4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2-yl)pyra zole-4-carbonitrile (92 mg, 0.4 mmol, 1.5 equiv.), ISfeCCL (84 mg, 0.79 mmol, 3 equiv.) and PdC^dppff CJbCh (43 mg, 0.05 mmol, 0.200 equiv.). The brown reaction mixture was stirred at 100 °C for 8 h under N2 atmosphere. The reaction mixture was cooled to rt, poured into H2O (10 mL) and extracted with EtOAc (3 x 40 mL). The combined organic layers were dried over ISfeSCU, filtered and concentrated under reduced pressure. The residue was purified by flash chromatography (silica gel, 10% MeOH in DCM). The title compound (20 mg, 16% yield) was obtained as a brown solid. LC-MS: m/z = 450.3 [M+H] ⁺ , ESI pos.

Step 4: 5-[ 3-(l -hydroxyethyl)-6-[5-[ ( 6-methylpyridazin-3-yl)amino ]benzimidazol-l-yl ]-2- pyridyl]-l-methyl-pyrazole-4-carbonitrile

Following the procedure described in example 75, with a reaction time of 1 h, the title compound (2.2 mg, 9.9% yield) was obtained as light yellow lyophilized solid. Purification by preparative HPLC: column Phenomenex Luna C18 (150mm x 25mm x 10pm). Flow rate: 25 mL / min. Gradient: 2% to 32% CH3CN in (0.225% formic acid in H2O v/v) (10 min) then 100% CH3CN (2 min). LC-MS: m/z = 452.2 [M+H] ⁺ , ESI pos. 'HNMR (400 MHz, CD3OD): 5 = 8.90 (s, 1H), 8.43 (d, J= 8.6 Hz, 1H), 8.34 (br s, 2H), 8.23 (s, 1H), 8.14 (br d, J= 8.4 Hz, 2H), 8.09 - 8.02 (m, 1H), 7.58 (dd, J = 1.9, 8.9 Hz, 1H), 7.36 (d, J = 9.1 Hz, 1H), 7.14 (d, J= 9.1 Hz, 1H), 3.86 (s, 3H), 2.53 (s, 3H), 1.59 - 1.41 (m, 3H).

Example 77 l-[3-(l-Hydroxyethyl)-6-[5-[(3R)-3-hydroxypyrrolidin-l-yl]be nzimidazol-l-yl]-2-pyridyl]- 5-methyl-pyrazole-3-carbonitrile; formic acid

Step 1: l-[6-(5-bromobenzimidazol-l-yl)-3-(l-hydroxyethyl)-2-pyridyl ]-5-methyl-pyrazole-3- carbonitrile

To a suspension of l-[3-acetyl-6-(5-bromobenzimidazol-l-yl)-2-pyridyl]-5-methyl -pyrazole-3- carbonitrile (obtained as in step 1 of example 65) (750 mg, 1.78 mmol, 1 equiv.) in MeOH (10 mL) and THF (10 mL) was added NaBT (202 mg, 5.34 mmol, 3 equiv.) at 0 °C. The mixture was stirred at 0 °C for 1 hour. The reaction mixture was then diluted with H2O (100 mL) and extracted with EtOAc (5 x 100 mL. The combined organics were washed with brine (2 x 100 mL), dried (ISfeSCL), filtered and concentrated to give the crude title compound (750 mg, 99.5% yield) as an off-white solid. LC-MS: m/z = 425.0 [M+H] ⁺ , ESI pos. ^J H NMR (400 MHz, CDCI3): 8 = 8.50 (s, 1H), 8.32 (d, J = 8.4 Hz, 1H), 7.96 (d, J= 1.8 Hz, 1H), 7.82 (d, J= 8.8 Hz, 1H), 7.69 (d, J= 8.4 Hz, 1H), 7.44 (dd, J = 1.8, 8.8 Hz, 1H), 6.64 (s, 1H), 4.81 (q, J= 6.5 Hz, 1H), 2.42 - 2.39 (m, 3H), 1.45 (d, J= 6.5 Hz, 3H). Step 2: l-[3-(l-hydroxyethyl)-6-[5-[(3R)-3-hydroxypyrrolidin-l-yl]be nzimidazol-l-yl]-2- pyridyl ]-5-methyl-pyrazole-3-carbonitrile; formic acid

Following the procedure described in step 2 of example 71, with (R)-3 -hydroxypyrrolidine (0.02 mL, 0.26 mmol, 1.1 equiv.), the title compound (17.3 mg, 16.2% yield) was obtained as yellow lyophilized solid. Purification by prep-HPLC: column Phenomenex Luna C18 (150mm x 25mm x 10pm). Flow rate: 25 mL / min. Gradient: 15% to 45% CH3CN in (0.225% formic acid in H2O v/v) (10 min) then 100% CH3CN (2 min). LC-MS: m/z = 430.1 [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, CD3OD): 5 = 8.80 (s, 1H), 8.48 (d, J = 8.5 Hz, 1H), 8.11 (d, J = 8.6 Hz, 1H), 8.02 (d, J = 9.0 Hz, 1H), 6.89 - 6.85 (m, 2H), 6.80 (dd, J = 2.0, 9.1 Hz, 1H), 4.77 (q, J = 6.5 Hz, 1H), 4.61 - 4.54 (m, 1H), 3.62 - 3.49 (m, 2H), 3.41 (dt, J= 3.8, 8.7 Hz, 1H), 3.28 (br d, J= 10.4 Hz, 1H), 2.42 (s, 3H), 2.28 - 2.18 (m, 1H), 2.12 - 2.02 (m, 1H), 1.43 (d, = 6.5 Hz, 3H).

Example 78 l-[3-(l-hydroxyethyl)-6-[5-[(3S)-3-hydroxypyrrolidin-l-yl]be nzimidazol-l-yl]-2-pyridyl]-5- methyl-pyrazole-3-carbonitrile; formic acid

Following the procedure described in step 2 of example 71, with (S)-3 -hydroxypyrrolidine (0.02 mL, 0.260 mmol, 1.1 equiv.), the title compound (21.6 mg, 18.1% yield) was obtained as yellow lyophilized solid. Purification by prep-HPLC: column Phenomenex Luna C18 (150mm x 25mm x 10pm). Flow rate: 25 mL / min. Gradient: 15% to 45% CH3CN in (0.225% formic acid in H2O v/v) (10 min) then 100% CH3CN (2 min). LC-MS: m/z = 430.1 [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, CD3OD): 5 = 8.78 (s, 1H), 8.46 (d, J= 8.4 Hz, 1H), 8.31 (s, 1H), 8.09 (d, J= 8.6 Hz, 1H), 8.00 (d, J= 9.0 Hz, 1H), 6.87 - 6.83 (m, 2H), 6.78 (dd, J= 2.3, 9.1 Hz, 1H), 4.77 - 4.72 (m, 1H), 4.59 - 4.53 (m, 1H), 3.58 - 3.48 (m, 2H), 3.39 (dt, J= 3.4, 8.6 Hz, 1H), 3.25 (br s, 1H), 2.40 (s, 3H), 2.27 - 2.14 (m, 1H), 2.11 - 1.99 (m, 1H), 1.41 (d, = 6.5 Hz, 3H).

Example 81

1- [3-(l-Hydroxyethyl)-6- [5- [(6-methyl-3-pyridyl)amino] benzimidazol-l-yl]-2-pyridyl]-5- methyl-pyrazole-3-carbonitrile

Step 1 : l-[ 3-acetyl-6-[5-[ ( 6-methyl-3-pyridyl)amino ]benzimidazol-l-yl ]-2-pyridyl ]-5-methyl- pyrazole-3-carbonitrile

Argon was bubbled for 5 min through a suspension of l-[3-acetyl-6-(5-bromobenzimidazol-l- yl)-2-pyridyl]-5-methyl-pyrazole-3-carbonitrile (obtained as in step 1 of example 65) (37 mg, 0.087 mmol, 1 equiv.), (6-methyl-3-pyridyl)amine (19 mg, 0.175 mmol, 2 equiv.) and CS2CO3 (85 mg, 0.262 mmol, 3 equiv.) at RT in 1,4-dioxane (1.2 mL). Then tBuXphos-Pd-G3 (7 mg, 0.009 mmol, 0.1 equiv.) was added, the vial was sealed, the mixture was then heated to 90 °C and stirring was continued for 4 hours. More tBuXphos-Pd-G3 (7 mg, 0.009 mmol, 0.1 equiv.) was added and the mixture was stirred for another 4 h at 90 °C. The reaction mixture was cooled to RT, adsorbed on silica gel and directly purified by flash chromatography (12 g silica gel, 0% to 100% [DCM / MeOH 9: 1] in DCM). The isolated product was purified again by flash chromatography (10g Si-NH2, 20% to 100% EtOAc in heptane). The title compound (21.7 mg, 46.9% yield) was obtained as a yellow solid. LC-MS: m/z = 449.2 [M+H] ⁺ , ESI pos. Step 2: l-[ 3-( 1 -hydroxyethyl)-6-[5-[ ( 6-methyl-3-pyridyl)amino ]benzimidazol-l-yl ]-2-pyridyl ]-5- methyl-pyrazole-3-carbonitrile To a solution of l-[3-acetyl-6-[5-[(6-methyl-3-pyridyl)amino]benzimidazol-l-y l]-2-pyridyl]-5- methyl-pyrazole-3 -carbonitrile (22 mg, 0.041 mmol, 1 equiv.) in MeOH (1 mL) was added NaBE (5 mg, 0.123 mmol, 3 equiv.) at 0 °C. The mixture was stirred at 0 °C for 30 min. The reaction mixture was quenched at 0 °C with NH4CI aq. sat. sol. and extracted with DCM. The organic layer was dried over MgSC , filtered and concentrated in vacuo. The residue was adsorbed on silica gel and purified by flash chromatography (4 g silica gel, 0% to 100% [DCM / MeOH 9: 1] in DCM). The title compound (11 mg, 58.8% yield) was obtained as a light yellow solid. LC-MS: m/z = 451.3 [M+H] ⁺ , ESI pos.

Example 82 l-[3-(l-Hydroxyethyl)-6-[5-[(5-methylpyrazin-2-yl)amino]benz imidazol-l-yl]-2-pyridyl]-5- methyl-pyrazole-3-carbonitrile

Step 1: l-[ 3-acetyl-6-[5-[ (5-methylpyrazin-2-yl)amino ]benzimidazol-l-yl ]-2-pyridyl ]-5-methyl- pyrazole-3-carbonitrile

Following the procedure described in step 1 of example 81, with (5-methylpyrazin-2-yl)amine (19 mg, 0.175 mmol, 2 equiv.), the title compound (12 mg, 29% yield) was obtained as a yellow solid. LC-MS: m/z = 450.2 [M+H] ⁺ , ESI pos. Step 2: l-[ 3-( 1 -hydroxyethyl)-6-[5-[ (5-methylpyrazin-2-yl)amino ]benzimidazol-l-yl ]-2-pyridyl /- 5-methyl-pyrazole-3-carbonitrile

Following the procedure described in step 2 of example 81, the title compound (4.5 mg, 37.3% yield) was obtained as an off-white solid. LC-MS: m/z = 452.3 [M+H] ⁺ , ESI pos. Example 83

1- [3-(l-Hydroxyethyl)-6- [5- [(5-methylpyrimidin-2-yl)amino] benzimidazol-l-yl]-2-pyridyl]- 5-methyl-pyrazole-3-carbonitrile Step 1: l-[3-acetyl-6-[5-[(5-methylpyrimidin-2-yl)amino]benzimidazol -l-yl]-2-pyridyl]-5- methyl-pyrazole-3-carbonitrile

Following the procedure described in step 1 of example 81, with (5-methylpyrimidin-2-yl)amine (27 mg, 0.237 mmol, 2 eq), the title compound (14.1 mg, 25.6% yield) was obtained as a light yellow solid. LC-MS: m/z = 450.2 [M+H] ⁺ , ESI pos.

Step 2: l-[ 3-( 1 -hydroxyethyl)-6-[5-[ (5-methylpyrimidin-2-yl)amino ]benzimidazol-l-yl ]-2- pyridyl]-5-methyl-pyrazole-3-carbonitrile

To a mixture of l-[3-acetyl-6-[5-[(5-methylpyrimidin-2-yl)amino]benzimidazol -l-yl]-2-pyridyl]- 5-methyl-pyrazole-3-carbonitrile (14 mg, 0.031 mmol, 1 eq) in MeOH (0.4 mL) was added NaBE (3 mg, 0.076 mmol, 3 eq) at 0 °C. The mixture was stirred at 0 °C for 15 min. Then THF (0.4 mL) was added to the mixture which turned to a clear solution. Stirring at 0 °C was continued for another 15 min. The reaction mixture was quenched at 0 °C with NH4CI aq. sat. sol. and extracted with DCM. The organic layer was dried over MgSCh, filtered and concentrated in vacuo. The residue was adsorbed on silica gel and purified by flash chromatography (4 g silica gel, 0% to 100% [DCM / MeOH 9: 1] in DCM). The title compound (9.2 mg, 63.7% yield) was obtained as a white solid. LC-MS: m/z = 452.3 [M+H] ⁺ , ESI pos.

Example 84 l-[3-(l-hydroxyethyl)-6-[5-[(5-methyl-2-pyridyl)amino]benzim idazol-l-yl]-2-pyridyl]-5- methyl-pyrazole-3-carbonitrile

Step 1: l-[3-acetyl-6-[5-[(5-methyl-2-pyridyl)amino]benzimidazol-l-y l]-2-pyridyl]-5-methyl- pyrazole-3-carbonitrile Following the procedure described in step 1 of example 81, with (5-methyl-2-pyridyl)amine (26 mg, 0.237 mmol, 2 equiv.), the title compound (27.5 mg, 46.5% yield) was obtained as a yellow solid. LC-MS: m/z = 449.2 [M+H] ⁺ , ESI pos.

Step 2: l-[ 3-( 1 -hydroxyethyl)-6-[5-[ (5 -me thy 1-2 -pyridyl) amino ]benzimidazol-l-yl ]-2-pyridyl ]-5- methyl-pyrazole-3-carbonitrile

To a mixture of l-[3-acetyl-6-[5-[(5-methyl-2-pyridyl)amino]benzimidazol-l-y l]-2-pyridyl]-5- methyl-pyrazole-3 -carbonitrile (27 mg, 0.061 mmol, 1 equiv.) in MeOH (0.8 mL) and THF, extra dry (0.8 mL) was added NaBEL (3 mg, 0.076 mmol, 3 equiv.) at 0 °C. The mixture was stirred at 0 °C for 15 min. The reaction mixture was quenched at 0 °C with NH4CI aq. sat. sol. and extracted with DCM. The organic layer was dried over MgSCh, filtered and concentrated in vacuo. The residue was adsorbed on silica gel and purified by flash chromatography (4 g silica gel, 0% to 100% [DCM / MeOH 9: 1] in DCM). The title compound (21 mg, 72.2% yield) was obtained as a light yellow solid. LC-MS: m/z = 451.4 [M+H] ⁺ , ESI pos. Example 85 l-[2-(l,l-dioxo-l,2-thiazolidin-2-yl)-6-[5-[(6-methylpyridaz in-3-yl)amino]benzimidazol-l- yl] -3-pyridyl] ethanol

Step 1: l-[6-chloro-2-(l, 1 -dioxo- l,2-thiazolidin-2-yl)-3-pyridyl] ethanone

To a solution of l-(6-chloro-2-fluoro-3-pyridyl)ethanone (CAS# 1260663-13-5, 500 mg, 2.88 mmol, 1 equiv.) in DMSO (10 mL) were added isothiazolidine 1,1-dioxide (349 mg, 2.88 mmol, 1 equiv.) and added K2CO3 (1.19 g, 8.64 mmol, 3 equiv.). The mixture was stirred at 30 °C for 2 hours. The mixture poured into H2O (30 mL) and extracted with EtOAc (3 x 15 mL). The combined organic extracts were washed with brine (3 x 15 mL), dried over anhydrous ISfeSCU, filtered and concentrated under reduced pressure. The residue was purified by flash chromatography (silica gel, 0% to 100% EtOAc in petroleum ether). The title compound (480 mg, 60.6% yield) was obtained as a light red solid. LC-MS: m/z = 274.8 [M+H] ⁺ , ESI pos.

Step 2: l-[2-(l,l-dioxo-l,2-thiazolidin-2-yl)-6-[5-[(6-methylpyridaz in-3-yl)amino]benzimidazol- 1-yl / -3-pyridyl ethanone and l-[ 2-( 1, 1 -dioxo- 1, 2-thiazolidin-2-yl)-5-[ 6-[ ( 6-methylpyridazin-3- yl)amino ]benzimidazol-l-yl / -3-pyridyl ethanone To a solution of l-[6-chloro-2-(l,l-dioxo-l,2-thiazolidin-2-yl)-3-pyridyl]eth anone (460 mg, 1.67 mmol, 1 equiv.) in DMSO (10 mL) were added N-(6-methylpyridazin-3-yl)-lH-benzimidazol-5- amine (obtained as in intermediate 1 of example 64) (453 mg, 2.01 mmol, 1.2 equiv.) and K2CO3 (694 mg, 5.02 mmol, 3 equiv.). The brown suspension was stirred at 80 °C for 2 hours. The mixture was directly purified by preparative HPLC: column Waters Xbridge C18 (150mm x 50mm x 10pm). Flow rate: 60 mL / min. Gradient: 16% to 46% CH3CN in (10 mM NH4HCO3 in H2O) (11 min) then 100% CH3CN (2 min). A 1 : 1 mixture of the 2 title compounds (150 mg) was isolated. Further purification by chiral SFC (Daicel Chiralpak AD (250mm x 30mm x 10pm). Flow rate: 70 mL / min. 50% (1% NH4OH in isopropanol) to yield l-[2-(l,l-dioxo-l,2- thiazolidin-2-yl)-6-[5-[(6-methylpyridazin-3-yl)amino]benzim idazol-l-yl]-3-pyridyl]ethanone (55 mg, 7.1% yield) as a brown solid and l-[2-(l,l-dioxo-l,2-thiazolidin-2-yl)-5-[6-[(6- methylpyridazin-3-yl)amino]benzimidazol-l-yl]-3-pyridyl]etha none (35 mg, 4.5% yield) as a grey solid. Regioisomer 1 : LC-MS: m/z = 464.0 [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, CDCI3): 5 ppm 2.50 (s, 3 H) 2.52 - 2.59 (m, 3 H) 2.63 (s, 3 H) 3.26 (t, J= 7.50 Hz, 2 H) 4.25 (t, J= 6.82 Hz, 2 H) 6.96 (d, J= 9.13 Hz, 1 H) 7.03 - 7.07 (m, 1 H) 7.07 - 7.10 (m, 1 H) 7.35 (d, J = 8.38 Hz, 1 H) 7.62 (d, J= 8.63 Hz, 1 H) 8.08 (d, J= 8.25 Hz, 1 H) 8.35 (s, 1 H) 8.74 (d, J= 1.75 Hz, 1 H). Regioisomer 2: LC-MS: m/z = 464.0 [M+H] ⁺ , ESI pos.

Step 3: l-[2-(l,l-dioxo-l,2-thiazolidin-2-yl)-6-[5-[(6-methylpyridaz in-3-yl)amino]benzimidazol- 1-yl ]-3-pyridyl ethanol

To a solution of l-[2-(l,l-dioxo-l,2-thiazolidin-2-yl)-6-[5-[(6-methylpyridaz in-3- yl)amino]benzimidazol-l-yl]-3-pyridyl]ethanone (45 mg, 0.1 mmol, 1 equiv.) in MeOH (3 mL) was added NaBT (112 mg, 0.29 mmol, 3 equiv.) at 0°C. The reaction mixture was stirred at 0 °C for 30 minutes. The mixture was quenched with saturated NH4CI (5 mL) at 0 °C and extracted with DCM (2 x 10 mL). The combined organics were dried over ISfeSCL, filtered and concentracted under reduce pressure. The crude product was purified by preparative HPLC: column Phenomenex Gemini-NX (75mm x 30mm x 30pm). Flow rate: 30 mL / min. Gradient: 10% to 40% CH3CN in (10 mM NH4HCO3 in H ₂ O) (8 min) then 100% CH3CN (2 min). The title compound (17.5 mg, 38.7% yield) was obtained as a white lyophilized solid. LC-MS: m/z = 466.1 [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, CD3OD): 5 ppm 1.56 (d, J = 6.36 Hz, 3 H) 2.54 - 2.63 (m, 5 H) 3.35 - 3.39 (m, 2 H) 4.10 - 4.19 (m, 1 H) 4.33 (dt, J= 10.70, 7.06 Hz, 1 H) 5.48 - 5.56 (m, 1 H) 7.15 (d, J= 9.17 Hz, 1 H) 7.27 - 7.32 (m, 1 H) 7.37 (d, J= 9.05 Hz, 1 H) 7.69 (d, J = 8.68 Hz, 1 H) 7.85 (d, J = 8.31 Hz, 1 H) 8.33 (d, J = 8.44 Hz, 1 H) 8.76 (s, 1 H) 9.08 (d, J = 1.83 Hz, 1 H).

Example 86

1- [3-(l-Hydroxyethyl)-6- [5- [(2-methylpyrimidin-5-yl)amino] benzimidazol-l-yl]-2-pyridyl]- 5-methyl-pyrazole-3-carbonitrile Step 1: l-[3-acetyl-6-[5-[(2-methylpyrimidin-5-yl)amino]benzimidazol -l-yl]-2-pyridyl]-5- methyl-pyrazole-3-carbonitrile

Following the procedure described in step 1 of example 81, with (2-methylpyrimidin-5-yl)amine (26 mg, 0.237 mmol, 2 equiv.), the title compound (41.5 mg, 70% yield) was obtained as a yellow solid. LC-MS: m/z = 450.3 [M+H] ⁺ , ESI pos.

Step 2: l-[ 3-( 1 -hydroxyethyl)-6-[5-[ (2-methylpyrimidin-5-yl)amino ]benzimidazol-l-yl -2- pyridyl]-5-methyl-pyrazole-3-carbonitrile

Following the procedure described in step 2 of example 84, the title compound (24.7 mg, 62.5% yield) was obtained as an off-white solid. LC-MS: m/z = 452.3 [M+H] ⁺ , ESI pos.

Example 87 l-[3-(l-Hydroxyethyl)-6-[5-(pyridazin-4-ylamino)benzimidazol -l-yl]-2-pyridyl]-5-methyl- pyrazole-3-carbonitrile

Step 1: l-[3-acetyl-6-[5-(pyridazin-4-ylamino)benzimidazol-l-yl]-2-p yridyl]-5-methyl-pyrazole- 3-carbonitrile

Following the procedure described in step 1 of example 81, with pyridazin-4-ylamine (23 mg, 0.237 mmol, 2 equiv.), the title compound (8.9 mg, 16.4% yield) was obtained as a yellow solid. LC-MS: m/z = 436.3 [M+H] ⁺ , ESI pos.

Step 2: l-[ 3-( 1 -hydroxyethyl)-6-[5-(pyridazin-4-ylamino)benzimidazol-l-yl ]-2-pyridyl -5- methyl-pyrazole-3-carbonitrile

Following the procedure described in step 2 of example 84, the title compound (4.1 mg, 43% yield) was obtained as a light yellow solid. LC-MS: m/z = 438.2 [M+H] ⁺ , ESI pos.

Example 88 1- [3-(l-Hydroxyethyl)-6- [5- [(6-methoxypyridazin-3-yl)amino] benzimidazol- 1-yl] -2- pyridyl]-5-methyl-pyrazole-3-carbonitrile

Step 1 : l-[ 3-acetyl-6-[5-[ ( 6-methoxypyridazin-3-yl)amino ] benzimidazol- 1-yl / -2 -pyridyl ]-5- methyl-pyrazole-3-carbonitrile

Following the procedure described in step 1 of example 81, with (6-methoxypyridazin-3- yl)amine (30 mg, 0.237 mmol, 2 equiv.), the title compound (59.7 mg, 97.3% yield) was obtained as a yellow solid. LC-MS: m/z = 466.3 [M+H] ⁺ , ESI pos.

Step 2: l-[ 3-( I -hydroxyethyl)-6-[5-[ ( 6-methoxypyridazin-3-yl)amino ] benzimidazol- 1-yl ]-2- pyridyl ]-5-methyl-pyrazole-3-carbonitrile

Following the procedure described in step 2 of example 84, the title compound (38.3 mg, 67.4% yield) was obtained as a light yellow solid. LC-MS: m/z = 468.3 [M+H] ⁺ , ESI pos.

Example 89 l-[3-(l-Hydroxyethyl)-6-[5-(pyridazin-3-ylamino)benzimidazol -l-yl]-2-pyridyl]-5-methyl- pyrazole-3-carbonitrile

Step 1: l-[3-acetyl-6-[5-(pyridazin-3-ylamino)benzimidazol-l-yl]-2-p yridyl]-5-methyl-pyrazole- 3-carbonitrile

Following the procedure described in step 1 of example 81, with pyridazin-3-ylamine (23 mg, 0.237 mmol, 2 equiv.), the title compound (15.3 mg, 26.6% yield) was obtained as a yellow solid. LC-MS: m/z = 436.3 [M+H] ⁺ , ESI pos.

Step 2: l-[ 3-( 1 -hydroxyethyl)-6-[5-(pyridazin-3-ylamino)benzimidazol-l-yl ]-2-pyridyl -5- methyl-pyrazole-3-carbonitrile

Following the procedure described in step 2 of example 84, the title compound (9.1 mg, 65% yield) was obtained as a light yellow solid. LC-MS: m/z = 438.3 [M+H] ⁺ , ESI pos.

Example 90 1- [6- [5- [[6-(Difluoromethyl)pyridazin-3-yl]amino] benzimidazol-l-yl]-3-(l-hydroxyethyl)-2- pyridyl]-5-methyl-pyrazole-3-carbonitrile

Step 1: l-[3-acetyl-6-[5-[[ 6-(difluoromethyl)pyridazin-3-yl] amino] benzimidazol-l-yl] -2- pyridyl]-5-methyl-pyrazole-3-carbonitrile

Following the procedure described in step 1 of example 81, with [6-(difluoromethyl)pyridazin-3- yl]amine (35 mg, 0.237 mmol, 2 equiv.), the title compound (35.2 mg, 55% yield) was obtained as a light yellow solid. LC-MS: m/z = 486.3 [M+H] ⁺ , ESI pos.

Step 2: l-[ 6-[5-[[ 6-(difluoromethyl)pyridazin-3-yl amino ] benzimidazol-l-yl ]-3-( I - hydroxyethyl)-2-pyridyl ]-5-methyl-pyrazole-3-carbonitrile

Following the procedure described in step 2 of example 84, the title compound (15.4 mg, 47% yield) was obtained as a light yellow solid. LC-MS: m/z = 488.2 [M+H] ⁺ , ESI pos.

Example 93

1- [6- [6-Fluoro-5- [(6-methylpyridazin-3-yl)amino] benzimidazol-l-yl]-3-(l-hydroxyethyl)-2- pyridyl]-5-methyl-pyrazole-3-carbonitrile

Step 1: N-(2-fluoro-4,5-dinitro-phenyl)-6-methyl-pyridazin-3-amine

To a solution of l,2-difluoro-4,5-dinitro-benzene (1.0 g, 4.9 mmol, 1 equiv.) in DMSO (12 mL) were added 3-amino-6-methylpyridazine (535 mg, 4.9 mmol, 1 equiv.) and potassium tert- butoxide (1.1 g, 9.8 mmol, 2 equiv.). The brown suspension was stirred at 30 °C for 3 hours. The reaction mixture was poured into H2O (100 mL). A solid precipitated out. The solid was collected by filtration and dried to give the crude title compound (600 mg, 41.8% yield) as a brown solid. LC-MS: m/z = 294.0 [M+H] ⁺ , ESI pos.

Step 2: 6-fluoro-N-( 6-methylpyridazin-3-yl)-lH-benzimidazol-5-amine To a solution of N-(2-fluoro-4,5-dinitro-phenyl)-6-methyl-pyridazin-3-amine (2.5 g, 8.53 mmol, 1 equiv.) in formic acid (30 mL, 795 mmol, 93.27 equiv.) was added Nickel (333 mg, 5.68 mmol, 0.670 equiv.). The mixture was stirred at 30 °C for 16 h under H2 (45 psi). The mixture was filtered and the filtrate was concentrated in vacuo. The residue was poured into MeOH (30 mL). A solid precipitated out. The solid was collected by filtration, washed with MeOH and dried to give a first crop of the title compound (480 mg). The filtrate was concentrated and the residue was purified by preparative HPLC: column Phenomenex Luna C18 (250mm x 70mm x 10pm). Flow rate: 80 mL / min. Gradient: 1% to 30% CH3CN in (0.225% formic acid in H2O v/v) (20 min) then 100% CH3CN (5 min). A second crop of the title compound (860 mg) was obtained. The title compound (1.34 g, 64.6% yield) was obtained as an off-white solid. LC-MS: m/z = 244.1 [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, DMSO-t/ ₆ ): 8 = 12.70 - 12.32 (m, 1H), 8.73 (br s, 1H), 8.51 - 8.37 (m, 1H), 8.20 - 8.09 (m, 2H), 7.49 (br d, J= 11.4 Hz, 1H), 7.33 (d, J = 9.2 Hz, 1H), 7.24 - 7.14 (m, 1H), 2.47 (s, 3H).

Step 3: l-[ 3-acetyl-6-[ 6-fluoro-5-[ ( 6-methylpyridazin-3-yl)amino ]benzimidazol-l-yl ]-2- pyridyl ]-5-methyl-pyrazole-3-carbonitrile and l-[ 3-acetyl-6-[5-fluoro-6-[ ( 6-methylpyridazin-3- yl)amino ]benzimidazol-l-yl / -2 -pyridyl ]-5-methyl-pyrazole-3-carbonitrile

To a solution of 6-fluoro-N-(6-methylpyridazin-3-yl)-lH-benzimidazol-5-amine (930 mg, 3.82 mmol, 1 equiv.) in DMSO (20 mL) were added l-(3-acetyl-6-chloro-2-pyridyl)-5-methyl- pyrazole-3 -carbonitrile (obtained as in step 1 of example 64) (1.2 g, 4.59 mmol, 1.2 equiv.) and K2CO3 (1.59 g, 11.47 mmol, 3 equiv.). The reaction mixture was stirred at 30 °C for 2 hours. The mixture was then poured into H2O (100 mL) and extracted with EtOAc (3 x 50 mL). The combined organic extracts were washed with brine (3 x 15 mL), dried over anhydrous ISfeSCU, filtered and concentrated. The residue was purified by preparative NPLC: column Welch Ultimate-XB-SiOH (250mm x 70mm x 10pm). Flow rate: 140 mL / min. Gradient: 20% to 60% EtOH in hexane (20 min) then 100% EtOH (4 min) to yield l-[3-acetyl-6-[6-fluoro-5-[(6- methylpyridazin-3-yl)amino]benzimidazol-l-yl]-2-pyridyl]-5-m ethyl-pyrazole-3-carbonitrile (200 mg, 11.2% yield) as a yellow solid and l-[3-acetyl-6-[5-fluoro-6-[(6-methylpyridazin-3- yl)amino]benzimidazol-l-yl]-2-pyridyl]-5-methyl-pyrazole-3-c arbonitrile (500 mg, 28% yield) as a yellow solid. Regioisomer 1 : LC-MS: m/z = 468.1 [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, DMSO-t/e): 8 = 9.17 (s, 1H), 8.90 (s, 1H), 8.72 (d, J= 7.7 Hz, 1H), 8.57 (d, J= 8.4 Hz, 1H), 8.34 (d, J= 8.6 Hz, 1H), 8.08 (d, J= 11.6 Hz, 1H), 7.41 - 7.35 (m, 1H), 7.29 - 7.23 (m, 1H), 7.16 (s, 1H), 2.54 (s, 3H), 2.49 (br s, 3H), 2.23 (s, 3H). Regioisomer 2: LC-MS: m/z = 468.1 [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, CD3OD): 5 = 9.17 (d, J= 7.4 Hz, 1H), 8.88 (s, 1H), 8.48 (d, J = 8.4 Hz, 1H), 8.09 (d, J = 8.4 Hz, 1H), 7.52 (d, J= 11.0 Hz, 1H), 7.39 (d, J= 9.1 Hz, 1H), 7.25 (d, J= 9.1 Hz, 1H), 6.83 (s, 1H), 2.58 (s, 3H), 2.56 (s, 3H), 2.23 (s, 3H).

Step 6: l-[ 6-[ 6-fluoro-5-[ ( 6-methylpyridazin-3-yl)amino ]benzimidazol-l-yl ]-3-( 1 -hydroxyethyl)- 2-pyridyl]-5-methyl-pyrazole-3-carbonitrile

To a solution of l-[3-acetyl-6-[6-fluoro-5-[(6-methylpyridazin-3-yl)amino]ben zimidazol-l-yl]-2- pyridyl]-5-methyl-pyrazole-3-carbonitrile (200 mg, 0.430 mmol, 1 equiv.) in MeOH (7 mL) and DCM (3 mL) was added NaBJL (49 mg, 1.28 mmol, 3 equiv.) at 0°C. The reaction mixture was stirred at 0 °C for 30 minutes. The mixture was quenched with saturated NH4CI (5 mL) at 0 °C and extracted with DCM (2 x 10 mL). The combined organic layers were dried over ISfeSCU, filtered and concentracted under reduce pressure. The residue was purified by preparative HPLC: column Phenomenex Synergi C18 (150mm x 25mm x 10pm). Flow rate: 25 mL / min. Gradient: 8% to 38% CH3CN in (0.225% formic acid in H2O v/v) (20 min) then 100% CH3CN (3 min). The title compound (120 mg, 59.7% yield) was obtained as a white lyophilized solid. LC-MS: m/z = 470.2 [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, CD3OD): 5 = 9.00 - 8.89 (m, 1H), 8.61 - 8.46 (m, 2H), 8.24 - 8.12 (m, 1H), 8.07 - 7.95 (m, 1H), 7.41 (d, J= 9.1 Hz, 1H), 7.24 (d, J= 9.3 Hz, 1H), 6.90 (s, 1H), 4.78 (q, J = 6.5 Hz, 1H), 4.61 (br s, 1H), 2.56 (s, 3H), 2.43 (s, 3H), 1.43 (d, J = 6.5 Hz, 3H). Example 94

1- [6- [5-Fluoro-6- [(6-methylpyridazin-3-yl)amino] benzimidazol-l-yl]-3-(l-hydroxyethyl)-2- pyridyl]-5-methyl-pyrazole-3-carbonitrile

Following the procedure described in step 6 of example 93, using MeOH (3 mL) as solvent, the title compound (11.6 mg, 23.1% yield) was obtained as a white lyophilized solid. Purification by preparative HPLC (Phenomenex Gemini NX C18 (75mm x 30mm x 3pm). Flow rate: 30 mL / min. Gradient: 18% to 48% CH ₃ CN in (10 mM NH4HCO3 in H2O) (8 min) then 100% CH3CN (2 min). LC-MS: m/z = 470.2 [M+H] ⁺ , ESI pos. 'HNMR (400 MHz, CD3OD): 5 ppm 1.43 (d, J = 6.48 Hz, 3 H) 2.35 - 2.40 (m, 3 H) 2.55 - 2.61 (m, 3 H) 4.72 - 4.84 (m, 1 H) 6.78 - 6.84 (m, 1 H) 7.20 - 7.27 (m, 1 H) 7.34 - 7.42 (m, 1 H) 7.52 - 7.62 (m, 1 H) 8.12 - 8.23 (m, 1 H) 8.51 - 8.63 (m, 1 H) 8.88 (s, 1 H) 9.00 - 9.09 (m, 1 H).

Example 97

1- [6- [5- [(6-Methylpyridazin-3-yl)amino] benzimidazol- 1-yl] -2- [3-(trifluoromethyl)-4, 5,6,7- tetrahydropyrazolo [4, 3-c] pyridin-l-yl]-3-pyridyl] ethanol

Step 1: tert-butyl l-(3-acetyl-6-chloro-2-pyridyl)-3-(trifluoromethyl)-6, 7-dihydro-4H- pyrazolo[ 4, 3-c ]pyridine-5-carboxylate

To a solution of l-(6-chloro-2-fhioro-3-pyridyl)ethanone (CAS# 1260663-13-5, 500 mg, 2.88 mmol, 1 equiv.) in DMSO (8 mL) were added DIPEA (745 mg, 5.76 mmol, 2 equiv.) and tertbutyl 3-(trifluoromethyl)-l,4,6,7-tetrahydropyrazolo[4,3-c]pyridin e-5-carboxylate (839 mg, 2.88 mmol, 1 equiv.). The reaction mixture was stirred at 80 °C for 7 hours. The mixture was cooled to rt, poured into H2O (50 mL) and extracted with EtOAc (3 x 50 mL). The combined organic layers were concentracted and the residue was purified by flash chromatography (silica gel, 20% EtOAc in petroleum ether). The title (1.11 g, 86.6% yield) was obtained as a light yellow oil. LC-MS: m/z = 389.0 [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, CDCI3): 8 = 7.83 (d, J = 8.0 Hz, 1H), 7.38 (d, J = 8.0 Hz, 1H), 4.57 (br s, 2H), 3.77 (br t, J = 5.3 Hz, 2H), 3.23 (br t, J = 5.5 Hz, 2H), 2.31 (s, 3H), 1.51 (s, 9H).

Step 2: tert-butyl l-[3-acetyl-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol -l-yl]-2- pyridyl] -3 -(trifluoromethyl) -6, 7-dihydro-4H-pyrazolo[4,3-c]pyridine-5-carboxylate and tertbutyl l-[ 3-acetyl-6-[ 6-[ ( 6-methylpyridazin-3-yl)amino ]benzimidazol-l-yl / -2 -pyridyl J-3-

(trijluoromethyl)-6, 7-dihydro-4H-pyrazolo [4, 3-c] pyridine-5-carboxylate

Following the procedure described in step 3 of example 76, with a reaction time of 72 h at 50 °C, the crude material was purified by preparative NPLC: column Welch Ultimate XB-CN (250mm x 70mm x 10pm). Flow rate: 140 mL / min. Gradient: 35% to 75% (0.1% NH4OH in EtOH v/v) in heptane (15 min), then 0.1% NH4OH in EtOH (3 min) to yield tert-butyl l-[3-acetyl-6-[5-[(6- methylpyridazin-3-yl)amino]benzimidazol-l-yl]-2-pyridyl]-3-( trifluoromethyl)-6,7-dihydro-4H- pyrazolo[4,3-c]pyridine-5-carboxylate (1.5 g, 40.1% yield) as a brown solid and tert-butyl l-[3- acetyl-6-[6-[(6-methylpyridazin-3-yl)amino]benzimidazol-l-yl ]-2-pyridyl]-3-(trifluoromethyl)- 6,7-dihydro-4H-pyrazolo[4,3-c]pyridine-5-carboxylate (1.4 g, 38.2% yield) as a brown solid. Regioisomer 1 : LC-MS: m/z = 634.3 [M+H] ⁺ , ESI pos. ‘H NMR (400 MHz, CD3OD): 5 = 8.90 (s, 1H), 8.34 (d, J= 8.3 Hz, 1H), 8.30 (d, J= 1.4 Hz, 1H), 8.09 (d, J= 8.9 Hz, 1H), 8.01 (d, J = 8.3 Hz, 1H), 7.63 (br d, J = 8.4 Hz, 1H), 7.38 (d, J= 9.1 Hz, 1H), 7.15 (d, J= 9.1 Hz, 1H), 4.63 (s, 2H), 3.79 (br t, J= 5.7 Hz, 2H), 3.21 (br t, J= 5.4 Hz, 2H), 2.55 (s, 3H), 2.27 (s, 3H), 1.52 (s, 9H). Regioisomer 2: LC-MS: m/z = 634.3 [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, CD ₃ OD): 5 = 8.94 (s, 1H), 8.59 (s, 1H), 8.16 (d, J= 8.2 Hz, 1H), 7.78 (d, J= 8.2 Hz, 1H), 7.50 (d, J= 8.8 Hz, 1H), 7.24 - 7.18 (m, 2H), 6.97 (d, J = 9.0 Hz, 1H), 4.42 (s, 2H), 3.19 (d, J = 1.1 Hz, 2H), 3.14 - 3.06 (m, 2H), 2.40 (s, 3H), 2.14 (s, 3H), 1.31 (br s, 9H).

Step 3: l-[6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-l-yl]-2- [3-(trifluoromethyl)- 4, 5, 6, 7-tetrahydropyrazolo[ 4, 3-c ]pyridin-l-yl (-3-pyridyl (ethanone; hydrochloride

Following the procedure described in step 2 of example 72, the crude title compound (1.2 g, 95% yield) was obtained as a light brown solid. LC-MS: m/z = 534.2 [M+H] ⁺ , ESI pos. Step 4: l-[ 6-[5-[ ( 6-methylpyridazin-3-yl)amino ]benzimidazol-l-yl (-2-[ 3 -(trifluor ome thy I) - 4, 5, 6, 7-tetrahydropyrazolo[ 4, 3-c ]pyridin-l-yl (-3-pyridyl (ethanol

Following the procedure described in step 6 of example 93, using MeOH (4 mL) as solvent, the title compound (33.2 mg, 36.3% yield) was obtained as a white lyophilized solid. Purification by preparative HPLC: column Waters Xbridge (150mm x 25mm x 5pm). Flow rate: 25 mL / min. Gradient: 21% to 51% CH3CN in (10 mM NH4HCO3 in H2O) (10 min) then 100% CH3CN (2 min). LC-MS: m/z = 536.2 [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, CD3OD): 5 = 8.87 (s, 1H), 8.52 (d, J= 8.4 Hz, 1H), 8.19 (d, J= 1.7 Hz, 1H), 8.09 (dd, J= 8.6, 14.5 Hz, 2H), 7.70 - 7.62 (m, 1H), 7.36 (d, J= 9.0 Hz, 1H), 7.13 (d, J= 92 Hz, 1H), 5.07 (q, J= 6.3 Hz, 1H), 4.14 (br s, 2H), 3.28 - 3.15 (m, 2H), 3.14 - 3.04 (m, 1H), 3.02 - 2.93 (m, 1H), 2.53 (s, 3H), 1.47 (d, J = 6.5 Hz, 3H).

Example 98

1- [6- [6- [(6-Methylpyridazin-3-yl)amino] benzimidazol- 1-yl] -2- [3-(trifluoromethyl)-4, 5,6,7- tetrahydropyrazolo [4,3-c] pyridin-l-yl]-3-pyridyl] ethanol

Step 1 : l-[ 6-[ 6-[ ( 6-methylpyridazin-3-yl)amino ]benzimidazol-l-yl ]-2-[ 3 -(trifluor ome thy I) - 4,5, 6, 7-tetrahydropyrazolo[4,3-c]pyridin-l-yl] -3-pyridyl] ethanone; hydrochloride Following the procedure described in step 2 of example 72, using tert-butyl l-[3-acetyl-6-[6-[(6- methylpyridazin-3-yl)amino]benzimidazol-l-yl]-2-pyridyl]-3-( trifluoromethyl)-6,7-dihydro-4H- pyrazolo[4,3-c]pyridine-5-carboxylate (obtained as in step 2 of example 97) (1.4 g, 2.20 mmol, 1 equiv.), the crude title compound (1.12 g, 95% yield) was obtained as a light brown solid. LC- MS: m/z = 534.2 [M+H] ⁺ , ESI pos. Step 2: l-[6-[6-[(6-methylpyridazin-3-yl)amino]benzimidazol-l-yl]-2- [3-(trifluoromethyl)- 4, 5, 6, 7-tetrahydropyrazolo[ 4, 3-c ]pyridin-l-yl / -3-pyridyl (ethanol Following the procedure described in step 6 of example 93, using MeOH (4 mL) as solvent, the title compound (10.2 mg, 10.6% yield) was obtained as a yellow lyophilized solid. Purification by preparative HPLC: column Phenomenex Synergi C18 (150mm x 25mm x 10pm). Flow rate: 25 mL / min. Gradient: 2% to 32% CH3CN in (0.225% formic acid in H2O v/v) (8.5 min) then 100% CH3CN (2 min). LC-MS: m/z = 536.2 [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, CD3OD): 5

= 8.92 - 8.83 (m, 2H), 8.54 (d, J= 8.6 Hz, 1H), 8.50 - 8.44 (m, 1H), 8.06 (d, J= 8.4 Hz, 1H), 7.74 - 7.66 (m, 1H), 7.40 (d, J= 9.0 Hz, 1H), 7.23 (dd, J= 1.9, 8.5 Hz, 1H), 7.18 - 7.11 (m, 1H), 5.26 (q, J= 6.1 Hz, 1H), 4.43 (br s, 2H), 3.85 - 3.68 (m, 1H), 3.55 - 3.46 (m, 1H), 3.45 - 3.36 (m, 2H), 2.56 (s, 3H), 1.51 (d, J= 6.5 Hz, 3H). Example 103

1- [3-(l-Hydroxyethyl)-6- [5- [(5-methyl- 1 ,3,4-oxadiazol-2-yl)amino] benzimidazol- 1-yl] -2- pyridyl]-5-methyl-pyrazole-3-carbonitrile

Step 1: l-[3-acetyl-6-[5-[(5-methyl-l ,3,4-oxadiazol-2-yl)amino]benzimidazol-l-yl] -2-pyridyl] - 5-methyl-pyrazole-3-carbonitrile

According to the procedure described in step 1 of example 81, with (5-methyl-l,3,4-oxadiazol-2- yl)amine (25 mg, 0.237 mmol, 2 equiv.), the title compound (15.4 mg, 28.6% yield) was obtained as a light yellow solid. LC-MS: m/z = 440.3 [M+H] ⁺ , ESI pos. Step 2: l-[ 3-( 1 -hydroxyethyl)-6-[5-[ (5-methyl-l, 3, 4-oxadiazol-2-yl)amino ]benzimidazol-l-yl ]-2- pyridyl]-5-methyl-pyrazole-3-carbonitrile

Following the procedure described in step 2 of example 84, the title compound (8.3 mg, 52.5% yield) was obtained as a white solid. LC-MS: m/z = 442.2 [M+H] ⁺ , ESI pos.

Example 104

2- [3-(l-Hydroxyethyl)-6- [5- [(6-methylpyridazin-3-yl)amino] benzimidazol-l-yl]-2-pyridyl]- 5-methyl-pyrazole-3-carbonitrile Step 1: 2-(3-acetyl-6-chloro-2-pyridyl)-5-methyl-pyrazole-3-carbonit rile l-(3-acetyl-6-chloro-2-pyridyl)-5-methyl-pyrazole-3-carbonit rile (obtained in step 1 of example 64) (6.03 g, 23.12 mmol) was purified by chiral SFC (Chiral IG (250mm x 30 mm x 5pm). 13% MeOH). The title compound (747 mg, 11.1% yield) was obtained as a white solid. LC-MS: m/z = 261.1 [M+H] ⁺ , ESI pos.; ‘H NMR (600 MHz, CDC1 ₃ ): 8 = 7.83 (d, J= 8.0 Hz, 1H), 7.42 (d, J

= 8.0 Hz, 1H), 6.89 (s, 1H), 2.35 (s, 3H), 2.28 (s, 3H). Step 2: 2-[ 3-acetyl-6-(5-bromobenzimidazol-l-yl)-2-pyridyl ]-5-methyl-pyrazole-3-carbonitrile and 2-[ 3-acetyl-6-( 6-bromobenzimidazol-l-yl)-2 -pyridyl ]-5-methyl-pyrazole-3-carbonitrile

To a solution of 2-(3-acetyl-6-chloro-2-pyridyl)-5-methyl-pyrazole-3-carbonit rile (459 mg, 1.76 mmol, 1 equiv.) and 5-bromo-lH-benzimidazole (354 mg, 1.76 mmol, 1.0 equiv.) in DMSO (9 mL) was added l,8-diazabicyclo[5.4.0]undec-7-ene (402 mg, 398 pL, 2.64 mmol, 1.5 equiv.). The reaction mixture was stirred at 23 °C for 24 hours. The mixture was poured into H2O and extracted with EtOAc. The organic layer was dried over MgSCU, filtered and concentrated in vacuo. The crude material was purified by flash chromatogaphy (25 g silica gel, 0% to 100% [DCM:MeOH 9: 1] in DCM). Further purification by chiral SFC was required for the separation of the regioisomers (Chiral OZ-H (250mm x 20 mm x 5 pm). 50% (0.2% di ethylamine) in MeOH) to give 2-[3-acetyl-6-(5-bromobenzimidazol-l-yl)-2-pyridyl]-5-methyl -pyrazole-3- carbonitrile (183.5 mg, 24.4% yield) as an off-white solid, and 2-[3-acetyl-6-(6- bromobenzimidazol-l-yl)-2-pyridyl]-5-methyl-pyrazole-3-carbo nitrile (129 mg, 17.1% yield) as an off-white solid. Regioisomer 1 : LC-MS: m/z = 421.0 [M+H] ⁺ , ESI pos. 'H NMR (600 MHz, DMSO- e): 5 = 9.20 - 9.09 (m, 1H), 8.40 (d, J= 8.4 Hz, 1H), 8.31 (d, J= 8.8 Hz, 1H), 8.19 (d, J = 8.4 Hz, 1H), 8.04 (d, J= 2.0 Hz, 1H), 7.58 (dd, J= 2.0, 8.7 Hz, 1H), 7.48 (s, 1H), 2.33 (s, 3H), 2.30 (s, 3H) Regioisomer 2: LC-MS: m/z = 421.0 [M+H] ⁺ , ESI pos. 'H NMR (600 MHz, DMSO-t/e): 5 = 9.15 (s, 1H), 8.60 (d, J= 1.9 Hz, 1H), 8.48 - 8.46 (m, 1H), 8.40 (d, J= 8.3 Hz, 1H), 8.36 - 8.32 (m, 1H), 8.23 (d, J= 8.4 Hz, 1H), 7.93 - 7.84 (m, 1H), 7.77 (d, J= 8.6 Hz, 1H), 7.55 (dd, J = 1.9, 8.6 Hz, 1H), 7.50 (s, 1H), 2.44 - 2.44 (m, 1H), 2.33 - 2.32 (m, 1H), 2.33 (s, 2H), 2.31 (s, 3H).

Step 3: 2-[ 3-acetyl-6-[5-[ ( 6-methylpyridazin-3-yl)amino ]benzimidazol-l-yl ]-2-pyridyl ]-5- methyl-pyrazole-3-carbonitrile Argon was bubbled for 5 min through a suspension of 2-[3-acetyl-6-(5-bromobenzimidazol-l- yl)-2-pyridyl]-5-methyl-pyrazole-3-carbonitrile (50 mg, 0.119 mmol, 1.0 equiv.), (6- methylpyridazin-3-yl)amine (26 mg, 0.237 mmol, 2 equiv.) and CS2CO3 (116 mg, 0.356 mmol, 3.0 equiv.) at RT in 1,4-dioxane (1.2 mL). Then [tBuBrettPhos Pd(allyl)]OTf (17 mg, 0.024 mmol, 0.2 equiv.) was added, the vial was sealed, the mixture was then heated to 80 °C and stirring was continued for 2 hours. The reaction mixture was cooled to RT, adsorbed on silica gel and directly purified by flash chromatography (12 g silica gel, 0% to 100% [DCM / MeOH 9: 1] in DCM). The title compound (36.8 mg, 65.5% yield) was obtained as a yellow solid. LC-MS: m/z = 450.3 [M+H] ⁺ , ESI pos. Step 4: 2-[3-(l-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino]be nzimidazol-l-yl]-2- pyridyl]-5-methyl-pyrazole-3-carbonitrile

Following the procedure described in step 2 of example 84, the title compound (11.3 mg, 30.2% yield) was obtained as an off-white solid. LC-MS: m/z = 452.3 [M+H] ⁺ , ESI pos. Example 105

(3R)-l-[3-(l-Hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl) amino]benzimidazol-l-yl]-2- pyridyl]pyrrolidine-3-carbonitrile Step 1 : (3R)-l-[3-(l -hydroxyethyl)-6-[5-[ ( 6-methylpyridazin-3-yl)amino ]benzimidazol-l-yl ]-2- pyridyl]pyrrolidine-3-carbonitrile

To a solution of l-(6-chloro-2-fhioro-3-pyridyl)ethanone (CAS# 1260663-13-5, 400 mg, 2.3 mmol, 1 equiv.) and (R)-pyrrolidine-3 -carbonitrile hydrochloride (336 mg, 2.54 mmol, 1.1 equiv.) in DMSO (6 mL) was added DIPEA (1.14 mL, 6.91 mmol, 3 equiv.). the reaction mixture was stirred at 30 °C for 3 hours. The mixture was poured into H2O (50 mL) and extracted with EtOAc (3 x 50 mL x 3). The combined organic layers were washed with brine( 100 mL) and concentrated under vacuum. The residue was purified by flash chromatography (silica gel, 20% to 50% EtOAc in petroleum ether). The title compound (680 mg, quantitative yield) was obtained as a light green oil. LC-MS: m/z = 250.1 [M+H] ⁺ , ESI pos.

Step 2: (3R)-l-[3-acetyl-6-[5-[(6-methylpyridazin-3-yl)amino]benzimi dazol-l-yl]-2- pyridyl ]pyrrolidine-3-carbonitrile and ( 3R)-l-[ 3-acetyl-6-[ 6-[ ( 6-methylpyridazin-3- yl)amino ]benzimidazol-l-yl / -2 -pyridyl ]pyrrolidine-3-carbonitrile

To a solution of (3R)-1 -(3 -acetyl-6-chloro-2-pyridyl)pyrrolidine-3 -carbonitrile (460 mg, 1.84 mmol, 1 equiv.) in DMSO (9 mL) were added N-(6-methylpyridazin-3-yl)-lH-benzimidazol-5- amine (obtained as in intermediate 1 of example 64) (498 mg, 2.21 mmol, 1.2 equiv.) and K2CO3 (764 mg, 5.53 mmol, 3 equiv.). The brown suspension was then stirred at 80 °C for 16 hours. The mixture was cooled to RT, poured into H2O (80 mL) and extracted with EtOAc (3 x 80 mL). The combined organic layers were washed with brine, dried over ISfeSCU, filtered and concentrated in vacuo. The residue was purified by preparative NPLC (Welch Ultimate XB-CN (250mm x 70mm x lOum). Flow rate 140 mL / min. Gradient: 55% to 95% EtOH in hexane (12 min) then 100% EtOH (5 min)) to give (3R)-l-[3-acetyl-6-[5-[(6-methylpyridazin-3- yl)amino]benzimidazol-l-yl]-2-pyridyl]pyrrolidine-3-carbonit rile (250 mg, 30.9% yield) as a yellow solid and (3R)-l-[3-acetyl-6-[6-[(6-methylpyridazin-3-yl)amino]benzimi dazol-l-yl]-2- pyridyl]pyrrolidine-3-carbonitrile (250 mg, 30.9% yield) as a yellow solid. Regioisomer 1 : LC- MS: m/z = 439.1 [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, DMSO-t/ ₆ ): 8 = 9.20 (s, 1H), 9.01 (s, 1H), 8.36 - 8.24 (m, 3H), 7.61 (dd, J= 2.0, 8.9 Hz, 1H), 7.37 - 7.26 (m, 2H), 7.09 (d, J= 9.0 Hz, 1H), 3.72 - 3.39 (m, 7H), 2.62 (s, 3H), 2.48 (br s, 3H). Regioisomer 2: LC-MS: m/z = 439.1 [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, DMSO-t/ ₆ ): 6 = 9.54 (d, J = 1.7 Hz, 1H), 9.31 (s, 1H), 8.90 (s, 1H), 8.31 (d, .7= 8.3 Hz, 1H), 7.65 (d, J= 8.7 Hz, 1H), 7.35 (d, J= 9.0 Hz, 1H), 7.25 (d, J = 8.3 Hz, 1H), 7.19 (dd, J = 2.0, 8.7 Hz, 1H), 7.11 (d, J = 9.0 Hz, 1H), 3.97 (br dd, J= 6.9, 11.6 Hz, 1H), 3.70 (br dd, J= 5.6, 11.6 Hz, 1H), 3.60 - 3.42 (m, 4H), 2.62 (s, 3H), 2.52 (s, 3H), 1.05 (t, 7 = 7.0 Hz, 1H).

Step 3: (3R)-l-[ 3-( 1 -hydroxyethyl)-6-[5-[ ( 6-methylpyridazin-3-yl)amino ]benzimidazol-l-yl ]-2- pyridyl]pyrrolidine-3-carbonitrile

Following the procedure described in step 2 of example 98, the title compound (125 mg, 47.3% yield) was obtained as a yellow solid. Purification by preparative HPLC (Waters Xbridge (150mm x 25mm x 5pm). Flow rate: 25 mL / min. Gradient: 25% to 55% CH3CN in (10 mM NH4HCO3 in H2O) (8 min) then 100% CH3CN (2 min)). LC-MS: m/z = 441.1 [M+H] ⁺ , ESI pos. ^J H NMR (400 MHz, DMSO-t/ ₆ ): 6 = 9.15 (s, 1H), 8.84 (s, 1H), 8.31 - 8.27 (m, 1H), 8.18 - 8.13 (m, 1H), 7.98 (dd, J= 3.5, 8.1 Hz, 1H), 7.57 (br d, J= 9.0 Hz, 1H), 7.35 - 7.28 (m, 2H), 7.08 (d, J = 9.0 Hz, 1H), 5.05 (d, J= 6.5 Hz, 1H), 3.98 - 3.88 (m, 1H), 3.88 - 3.79 (m, 1H), 3.79 - 3.71 (m, 1H), 3.70 - 3.61 (m, 1H), 3.61 - 3.47 (m, 2H), 2.48 (s, 3H), 2.41 - 2.31 (m, 1H), 2.30 - 2.19 (m, 1H), 1.39 (dd, J= 4.6, 5.9 Hz, 3H).

Example 106 (3R)-l-[3-(l-Hydroxyethyl)-6-[6-[(6-methylpyridazin-3-yl)ami no]benzimidazol-l-yl]-2- pyridyl]pyrrolidine-3-carbonitrile

Following the procedure described in step 2 of example 98, starting with (3R)-l-[3-acetyl-6-[6- [(6-methylpyridazin-3-yl)amino]benzimidazol-l-yl]-2-pyridyl] pyrrolidine-3-carbonitrile (obtained in step 2 of example 105-A) (250 mg, 0.6 mmol, 1 equiv.), the title compound (115 mg, 44.2% yield) was obtained as a yellow solid. Purification by preparative HPLC (Waters Xbridge (150mm x 25mm x 5pm). Flow rate: 25 mL / min. Gradient: 23% to 53% CH3CN in (10 mM NH4HCO3 in H2O) (10 min) then 100% CH3CN (2 min)). LC-MS: m/z = 441.1 [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, DMSO-t/ ₆ ): 8 = 9.41 (dd, J= 1.7, 6.2 Hz, 1H), 9.26 (s, 1H), 8.70 (d, J= 4.8 Hz, 1H), 7.98 (dd, J = 3.6, 8.1 Hz, 1H), 7.63 (d, J= 8.6 Hz, 1H), 7.33 (d, J = 9.2 Hz, 1H), 7.25 (dd, J= 2.2, 7.9 Hz, 1H), 7.17 (br d, J= 8.7 Hz, 1H), 7.09 (d, J= 9.0 Hz, 1H), 5.07 (q, J= 6.1 Hz, 1H), 4.19 - 4.09 (m, 1H), 3.91 - 3.81 (m, 1H), 3.77 - 3.70 (m, 2H), 3.57 - 3.44 (m, 2H), 2.49 - 2.48 (m, 3H), 2.40 - 2.31 (m, 1H), 2.30 - 2.19 (m, 1H), 1.41 (t, J= 5.7 Hz, 3H).

Example 107 l-[2-(3,5-Dimethylpyrazol-l-yl)-6-[6-[(6-methylpyridazin-3-y l)amino]benzimidazol-l-yl]-3- pyridyl] ethanol; formic acid

Step 1 : l-[ 6-chloro-2-( 3, 5-dimethylpyrazol-l-yl)-3-pyridyl ] ethanone A solution of 3,5-dimethylpyrazole (200 mg, 2.08 mmol, 1 equiv.), l-(6-chloro-2-fluoro-3- pyridyl)ethanone (CAS# 1260663-13-5, 361 mg, 2.08 mmol, 1 equiv.) and DIPEA (810 mg, 6.27 mmol, 3.01 equiv.) in DMSO (3 mL) was stirred at 30 °C for 4 hours, then at 50 °C for another 4 hours, then at 80 °C for another 4 hours and then at 100 °C for another 14 hours. The reaction mixture was cooled to RT, quenched with H2O (30 mL) and extracted with EtOAc (3 x 10 mL). The combined organic layers were dried over Na2SO4, filtered and concentrated under reduced pressure. The residue was purified by flash chromatography (silica gel, 0% to 20% EtOAc in petroleum ether. The title compound (290 mg, 44.7% yield) was obtained as a light brown solid. LC-MS: m/z = 250.1 [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, CDCI3): 6 = 7.86 (d, J = 7.9 Hz, 1H), 7.31 (d, J= 7.9 Hz, 1H), 6.07 (s, 1H), 2.58 (s, 3H), 2.24 (s, 3H), 2.06 - 2.05 (m, 3H).

Step 2: l-[ 2-(3, 5-dimethylpyrazol-l-yl)-6-[5-[ ( 6-methylpyridazin-3-yl)amino ]benzimidazol-l- yl] -3-pyridyl ethanone and l-[ 2-( 3, 5-dimethylpyrazol-l-yl)-6-[ 6-[ ( 6-methylpyridazin-3- yl)amino ]benzimidazol-l-yl / -3-pyridyl ethanone

A solution of l-[6-chloro-2-(3,5-dimethylpyrazol-l-yl)-3-pyridyl]ethanone (280 mg, 1.12 mmol, 1 equiv.), N-(6-methylpyridazin-3-yl)-lH-benzimidazol-5-amine (308 mg, 1.37 mmol, 1.22 equiv.) and K2CO3 (476 mg, 3.44 mmol, 3.07 equiv.) in DMSO (3 mL) was stirred at 50 °C for 16 hours, then at 80 °C for 4 hours. The reaction mixture was cooled to RT, quenched with H2O (50 mL) and extracted with EtOAc (3 x 30 mL). The combined organic layers were dried over Na2SO4, filtered and concentrated under reduced pressure. The residue was purified by preparative NPLC (Welch Ultimate XB-CN (250mm x 50mm x 10pm). Flow rate: 100 mL / min. Gradient: 30% to 70% EtOH in hexane (15 min) then 100% EtOH (5 min)) to give l-[2- (3,5-dimethylpyrazol-l-yl)-6-[5-[(6-methylpyridazin-3-yl)ami no]benzimidazol-l-yl]-3- pyridyl] ethanone (90 mg, 18.3% yield) as a brown solid and l-[2-(3,5-dimethylpyrazol-l-yl)-6- [6-[(6-methylpyridazin-3-yl)amino]benzimidazol-l-yl]-3-pyrid yl]ethanone (90 mg, 18.3% yield) as a brown solid. Regioisomer 1 : LC-MS: m/z = 439.0 [M+H] ⁺ , ESI pos. ^J H NMR (400 MHz, CDCI3): 8 = 8.64 (s, 1H), 8.19 (d, J = 8.3 Hz, 1H), 8.07 (br d, J= 8.4 Hz, 1H), 7.80 (d, J= 1.8 Hz, 1H), 7.57 (d, J = 8.2 Hz, 1H), 7.40 (dd, J= 1.7, 8.7 Hz, 1H), 7.24 (br d, J= 5.0 Hz, 2H), 6.16 (s, 1H), 2.61 (d, J = 7.6 Hz, 6H), 2.30 (s, 3H), 2.09 (s, 3H). Regioisomer 2: LC-MS: m/z = - Ill -

439.0 [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, CD ₃ 0D): 5 = 8.85 (d, J = 1.8 Hz, 1H), 8.81 (s, 1H), 8.34 (d, J= 8.3 Hz, 1H), 7.96 (d, J = 8.2 Hz, 1H), 7.69 (d, J= 8.8 Hz, 1H), 7.47 (dd, J = 2.0, 8.7 Hz, 1H), 7.35 (d, J= 9.0 Hz, 1H), 7.13 (d, J= 9.2 Hz, 1H), 6.20 (s, 1H), 2.55 (d, J= 6.4 Hz, 6H), 2.25 (s, 3H), 2.04 (s, 3H).

Step 3: l-[ 2-(3, 5-dimethylpyrazol-l-yl)-6-[ 6-[ ( 6-methylpyridazin-3-yl)amino ]benzimidazol-l- yl] -3-pyridyl ethanol

To a solution of l-[2-(3,5-dimethylpyrazol-l-yl)-6-[6-[(6-methylpyridazin-3- yl)amino]benzimidazol-l-yl]-3-pyridyl]ethanone (80 mg, 0.18 mmol, 1 equiv.) in MeOH (1 mL) and DCM (9 mL) was added NaBH4 (21 mg, 0.56 mmol, 3.04 equiv.) at 0 °C. The reaction mixture was stirred at 0 °C for 15 minutes. The mixture was quenched with H2O (30 mL) and extracted with DCM (3 x 15 mL). The combined organic layers were dried over Na2SO4, filtered and concentrated under reduced pressure. The residue was by preparative HPLC (Phenomenex Luna C18 (150mm x 25mm x 10pm). Flow rate: 25 mL / min. Gradient: 7% to 37% CH3CN in (0.225% formic acid in H2O v/v) (10 min) then 100% CH3CN (2 min)). The title compound (30.4 mg, 37.8% yield) was obtained as a light yellow liophilized solid. LC-MS: m/z = 441.3 [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, CD3OD): 5 = 8.76 (s, 1H), 8.72 (s, 1H), 8.49 (d, J = 8.4 Hz, 1H), 8.05 (d, J= 8.3 Hz, 1H), 7.69 (d, J= 8.7 Hz, 1H), 7.46 (d, J= 8.8 Hz, 1H), 7.34 (d, J= 9.3 Hz, 1H), 7.15 (d, J= 9.2 Hz, 1H), 6.13 (s, 1H), 4.84 (m, 1H), 2.55 (s, 3H), 2.30 (d, J = 6.6 Hz, 6H), 1.36 (d, J= 6.5 Hz, 3H).

Example 108 l-[2-(3,5-Dimethylpyrazol-l-yl)-6-[5-[(6-methylpyridazin-3-y l)amino]benzimidazol-l-yl]-3- pyridyl] ethanol; formic acid

Following the procedure described in step 3 of example 107, starting with l-[2-(3,5- dimethylpyrazol-l-yl)-6-[5-[(6-methylpyridazin-3-yl)amino]be nzimidazol-l-yl]-3- pyridyl] ethanone (80 mg, 0.18 mmol, 1 equiv.), the title compound (42.1 mg, 52.4% yield) was obtained as a light yellow solid. Purification by preparative HPLC (Phenom enex Luna Cl 8 (150mm x 25mm x 10pm). Flow rate: 25 mL / min. Gradient: 7% to 37% CH3CN in (0.225% formic acid in H2O v/v) (10 min) then 100% CH3CN (2 min)). LC-MS: m/z = 441.3 [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, CD3OD): 5 = 8.88 (s, 1H), 8.43 (d, J = 8.3 Hz, 1H), 8.21 (d, J = 1.6 Hz, 1H), 8.15 (d, J = 8.9 Hz, 1H), 8.04 (d, J = 8.4 Hz, 1H), 7.61 - 7.55 (m, 1H), 7.38 (d, J= 9.3 Hz, 1H), 7.15 (d, J= 9.0 Hz, 1H), 6.18 (s, 1H), 4.84 (m, 1H), 2.54 (s, 3H), 2.32 (d, J = 6.1 Hz, 6H), 1.36 (d, J= 6.5 Hz, 3H).

Example 109 5-Methyl-l- [6- [5- [(6-methylpyridazin-3-yl)amino] benzimidazol-l-yl]-3-[(l S)-l- hydroxy ethyl] -2-pyridyl] pyrazole-3-carbonitrile l-[3-(l-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino]be nzimidazol-l-yl]-2-pyridyl]-5- methyl-pyrazole-3 -carbonitrile (obtained as in step 3 of example 64) (400 mg, 0.89 mmol, 1 equiv.) was purified by chiral SFC (Daicel Chiralpak AY-H (250mm x 30mm x 10pm). Flow rate: 70 mL / min. 60% (0.1% NH4OH in isopropanol). The title compound (157.5 mg, 39.4% yield) was obtained as a white solid. LC-MS: m/z = 452.2 [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, CD3OD): 5 = 8.89 (s, 1H), 8.50 (d, J= 8.5 Hz, 1H), 8.22 (d, J= 1.9 Hz, 1H), 8.13 (dd, J= 8.7, 15.2 Hz, 2H), 7.60 (dd, J = 2.1, 8.9 Hz, 1H), 7.35 (d, J = 9.1 Hz, 1H), 7.12 (d, J = 9.1 Hz, 1H), 6.87 (d, J= 0.6 Hz, 1H), 4.78 - 4.74 (m, 1H), 2.53 (s, 3H), 2.41 (s, 3H), 1.41 (d, J= 6.5 Hz, 3H).

Assignment of the absolute configuration of the stereogenic carbon was performed by Mosher ester analysis: 3.6 mg (8.0 pmol) of alcohol were dissolved in CDCI3 and 2.9 pl of pyridine (36.3 pmol, 7 equiv.), were added followed by of (A -Mosher chloride ((A)-a-Methoxy-a- trifluoromethylphenylacetyl chloride, 7.6 pl, 40.2 umol, 5.0 equiv.) for the formation of the corresponding (S -Mosher ester. Comparison with the 'H-NMR spectrum (COSY) of example 110 by overlay shows an upfield shift of the C2-m ethyl group hence indicating an (5)- configuration of the alcohol.

Example 110 5-Methyl-l-[6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol -l-yl]-3-[(lR)-l- hydroxy ethyl] -2-pyridyl] pyrazole-3-carbonitrile l-[3-(l-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino]be nzimidazol-l-yl]-2-pyridyl]-5- methyl-pyrazole-3 -carbonitrile (obtained as in step 3 of example 64) (400 mg, 0.89 mmol, 1 equiv.) was purified by chiral SFC (Daicel Chiralpak AY-H (250mm x 30mm x 10pm). Flow rate: 70 mL / min. 60% (0.1% NH4OH in isopropanol)). The title compound (174.5 mg, 43.6% yield) was obtained as a white solid. LC-MS: m/z = 452.2 [M+H] ⁺ , ESI pos. ^J H NMR (400 MHz, CD3OD): 5 = 8.89 (s, 1H), 8.50 (d, J= 8.4 Hz, 1H), 8.22 (d, J = 2.0 Hz, 1H), 8.16 - 8.08 (m, 2H), 7.59 (dd, J= 2.1, 8.9 Hz, 1H), 7.35 (d, J= 9.3 Hz, 1H), 7.12 (d, J= 9.1 Hz, 1H), 6.87 (s, 1H), 4.79 - 4.74 (m, 1H), 2.53 (s, 3H), 2.41 (s, 3H), 1.41 (d, J= 6.5 Hz, 3H).

Assignment of the absolute configuration of the stereogenic carbon was performed by Mosher ester analysis: 1.5 mg (3.3 pmol) of alcohol were dissolved in CDCI3 and 1.9 pl of pyridine (23.8 pmol, 7 equiv.), were added followed by of (A -Mosher chloride ((A)-a-Methoxy-a- trifluoromethylphenylacetyl chloride, 3.1 pl, 16.5 umol, 5.0 equiv.) for the formation of the corresponding (S -Mosher ester. Comparison with the 'H-NMR spectrum (COSY) of example 109 by overlay shows a downfield shift of the C2-methyl group hence indicating an (Reconfiguration of the alcohol. Example 111 l-[3-(l-Hydroxyethyl)-6-[5-[(5-methyl-l,3,4-thiadiazol-2-yl) amino]benzimidazol-l-yl]-2- pyridyl]-5-methyl-pyrazole-3-carbonitrile

Step J: l-[3-acetyl-6-[5-[(5-methyl-l ,3,4-thiadiazol-2-yl)amino]benzimidazol-l-yl] -2-pyridyl] - 5-methyl-pyrazole-3-carbonitrile

According to the procedure described in step 3 of example 104, with (5-methyl-l,3,4-thiadiazol- 2-yl)amine (27 mg, 0.237 mmol, 2 equiv.), the title compound (41.3 mg, 73.8% yield) was obtained as an off-white solid. LC-MS: m/z = 456.3 [M+H] ⁺ , ESI pos. Step 2: l-[ 3-( 1 -hydroxyethyl)-6-[5-[ (5-methyl-l, 3, 4-thiadiazol-2-yl)amino ]benzimidazol-l-yl -2- pyridyl]-5-methyl-pyrazole-3-carbonitrile Following the procedure described in step 2 of example 84, the title compound (9 mg, 21% yield) was obtained as a light yellow solid. LC-MS: m/z = 458.3 [M+H] ⁺ , ESI pos.

Example 113 l-[3-(l-Hydroxyethyl)-6-[5-[[l-(oxetan-3-yl)-4-piperidyl]oxy ]benzimidazol-l-yl]-2-pyridyl]- 5-methyl-pyrazole-3-carbonitrile

Step 1: 4-(3,4-dinitrophenoxy)-l-(oxetan-3-yl)piperidine l-(oxetan-3-yl)piperidin-4-ol (5.0 g, 31.8 mmol, 1 equiv.) and 3,4-dinitrofluorobenzene (6.51 g, 34.99 mmol, 1.1 equiv.) were dissolved in DMSO (8 mL), then potassium tert-butoxide (4.28 g, 38.17 mmol, 1.2 equiv.) was added and the mixture was stirred at 30 °C for 12 hours. The reaction mixture was then poured into H2O (50 mL) and extracted with EtOAc (3 x 30 mL). The combined organic layers were dried over ISfeSCU, filtered and concentrated under reduced pressure. The residue was first purified by flash chromatography (silica gel, 10% MeOH in DCM). The isolated material was then purified by preparative HPLC (Kromasil Eternity XT (250mm x 80mm x 10pm). Flow rate: 100 mL / min. Gradient: 35% to 65% CH3CN in (10 mM NH4HCO3 in H2O) (18 min) then 100% CH3CN (8 min)). The title compound (1.2 g, 11.7% yield) was obtained as a light brown solid. LC-MS: m/z = 324.0 [M+H] ⁺ , ESI pos.

Step 2: 4-[[ l-(oxetan-3-yl)-4-piperidyl] oxy] benzene- 1,2-diamine

To a solution of 4-(3,4-dinitrophenoxy)-l-(oxetan-3-yl)piperidine (1.2 g, 3.71 mmol, 1 equiv.) in a mixture of MeOH (16 mL) and THF (8 mL) was added 10% Pd/C (197 mg, 0.190 mmol, 0.050 equiv.). The mixture was stirred at 40 °C for 16 h under H2 (50 psi). The mixture was filtered and the filtrate was concentrated under reduced pressure. The residue was purified by flash chromatography (silica gel, 0% to 20% MeOH in EtOAc). The title compound (800 mg, 81.8% yield)was obtained as a light brown solid. LC-MS: m/z = 264.1 [M+H] ⁺ , ESI pos.

Step 3: 5-[[l-(oxetan-3-yl)-4-piperidyl]oxy]-lH-benzimidazole

A suspension of 4-[[l-(oxetan-3-yl)-4-piperidyl]oxy]benzene-l,2-diamine (800 mg, 3.04 mmol, 1 equiv.) in trimethyl orthoformate (6.45 g, 60.76 mmol, 20 equiv.) was stirred at 120 °C for 20 hours. The reaction mixture was cooled to RT and quenched with 1 N HC1 (1.5 mL) and THF (1.5 mL). The mixture was then stirred at 30 °C for 12 hours. The pH of the reaction mixture was adjusted to 7 by the addition of 1 N HC1. The mixture was extracted with EtOAc (2 x 15 mL). The combined organic layers were concentrated under reduced pressure. The crude title (800 mg, 96.3% yield) was obtained as a light brown solid. LC-MS: m/z = 274.1 [M+H] ⁺ , ESI pos.

Step 4: l-[3-acetyl-6-[5-[[ l-(oxetan-3-yl)-4-piperidyl] oxy]benzimidazol-l-yl] -2-pyridyl] -5- methyl-pyrazole-3-carbonitrile and l-[ 3-acetyl-6-[ 6-[[ l-(oxetan-3-yl)-4- piperidyl ]oxy]benzimidazol-l-yl / -2-pyridyl ]-5-methyl-pyrazole-3-carbonitrile

To a solution of 5-[[l-(oxetan-3-yl)-4-piperidyl]oxy]-lH-benzimidazole (400 mg, 1.46 mmol, 1 equiv.) in DMSO (8 mL) were added l-(3-acetyl-6-chloro-2-pyridyl)-5-methyl-pyrazole-3- carbonitrile (obtained as in step 1 of example 64) (458 mg, 1.76 mmol, 1.2 equiv.) and K2CO3 (607 mg, 4.39 mmol, 3 equiv.). The reaction mixture was stirred at 30 °C for 12 hours. The mixture was then poured into H2O (20 mL) and extracted with EtOAc (3 x 25 mL). The combined organic extracts were washed with brine (3 x 15 mL), dried over anhydrous Na2SO4, filtered and concentrated under reduced pressure. The residue was purified by flash chromatography (silica gel, 10% MeOH in DCM) to give l-[3-acetyl-6-[5-[[l-(oxetan-3-yl)-4- piperidyl]oxy]benzimidazol-l-yl]-2-pyridyl]-5-methyl-pyrazol e-3-carbonitrile (Rf 0.55, UV detection) (50 mg, 6.9% yield) as a light yellow oil and l-[3-acetyl-6-[6-[[l-(oxetan-3-yl)-4- piperidyl]oxy]benzimidazol-l-yl]-2-pyridyl]-5-methyl-pyrazol e-3-carbonitrile (Rf 0.6, UV detection) (50 mg, 6.9% yield) as a light yellow solid.. Regioisomer 1 : LC-MS: m/z = 498.2 [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, CDC1 ₃ ): 8 = 8.60 (s, 1H), 8.30 (d, J = 8.3 Hz, 1H), 7.93 (d, J= 9.0 Hz, 1H), 7.75 (d, J= 8.3 Hz, 1H), 7.39 (d, J= 2.0 Hz, 1H), 7.28 (s, 1H), 7.07 (dd, J= 1.9, 8.9 Hz, 1H), 6.73 (s, 1H), 4.70 (br d, J= 6.5 Hz, 4H), 4.52 - 4.42 (m, 1H), 3.58 (br s, 1H), 2.70 - 2.60 (m, 5H), 2.32 - 2.21 (m, 5H), 2.12 (br d, J = 3.4 Hz, 2H), 1.96 (br s, 2H). Regioisomer 2: LC-MS: m/z = 498.2 [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, CDCI3): 5 = 8.51 (s, 1H), 8.33 - 8.28 (m, 1H), 7.75 (d, J= 8.6 Hz, 2H), 7.57 (d, J= 2.1 Hz, 1H), 7.03 (dd, J= 2.2, 8.8 Hz, 1H), 6.71 (s, 1H), 4.70 - 4.62 (m, 4H), 4.40 - 4.32 (m, 1H), 3.57 - 3.50 (m, 1H), 2.63 - 2.56 (m, 5H), 2.23 - 2.15 (m, 5H), 2.02 (br d, J= 4.2 Hz, 2H), 1.94 - 1.84 (m, 2H).

Step 5: l-[ 3-( 1 -hydroxyethyl)-6-[5-[ [ 1 -(oxetan-3-yl)-4-piperidyl ]oxy]benzimidazol-l-yl -2- pyridyl]-5-methyl-pyrazole-3-carbonitrile

To a clear light brown solution of l-[3-acetyl-6-[5-[[l-(oxetan-3-yl)-4- piperidyl]oxy]benzimidazol-l-yl]-2-pyridyl]-5-methyl-pyrazol e-3-carbonitrile (50 mg, 0.1 mmol, 1 equiv.) in a mixture of MeOH (2.5 mL) and DCM (0.5 mL) was added NaBH4 (11 mg, 0.3 mmol, 3 equiv.) at 0 °C . Stirring at 0 °C was continued for 1 hours. The mixture was quenched with saturated NH4CI (5 mL) at 0 °C and extracted with EtOAc (2 x 10 mL). The combined organic layers were dried over Na2SO4, filtered and concentracted under reduced pressure. The residue was purified by preparative HPLC: column Waters Xbridge (150mm x 25mm x 5pm). Flow rate: 25 mL / min. Gradient: 25% to 55% CH3CN in (10 mM NH4HCO3 in H2O) (9 min) then 100% CH3CN (0.5 min). The title compound (20.5 mg, 40.8% yield) was obtained as an off-white solid. LC-MS: m/z = 500.2 [M+H] ⁺ , ESI pos. ‘H NMR (400 MHz, CD3OD): 5 = 8.91 (s, 1H), 8.51 (d, J = 8.4 Hz, 1H), 8.14 (d, J = 8.4 Hz, 1H), 8.09 (d, J= 9.0 Hz, 1H), 7.32 (d, J = 2.1 Hz, 1H), 7.08 (dd, J= 2.3, 9.0 Hz, 1H), 6.88 (s, 1H), 4.80 - 4.71 (m, 3H), 4.64 (d, J= 6.4 Hz, 2H), 4.58 - 4.51 (m, 1H), 3.67 - 3.59 (m, 1H), 2.76 - 2.66 (m, 2H), 2.41 (s, 3H), 2.37 (br dd, J= 4.3, 5.6 Hz, 2H), 2.13 - 2.07 (m, 2H), 1.94 - 1.86 (m, 2H), 1.43 (d, J= 6.5 Hz, 3H). Example 114 l-[3-(l-Hydroxyethyl)-6-[6-[[l-(oxetan-3-yl)-4-piperidyl]oxy ]benzimidazol-l-yl]-2-pyridyl]-

5-methyl-pyrazole-3-carbonitrile Following the procedure described in step 5 of example 113, starting with l-[3-acetyl-6-[6-[[l- (oxetan-3-yl)-4-piperidyl]oxy]benzimidazol-l-yl]-2-pyridyl]- 5-methyl-pyrazole-3-carbonitrile (obtained in step 4 of example 113) (50 mg, 0.1 mmol, 1 equiv.) and using MeOH (2.5 mL) as solvent, the title compound (17 mg, 33.9% yield) was obtained as an off-white lyophilized solid. Purificationby preparative HPLC (Waters Xbridge (150mm x 25mm x 5pm). Flow rate: 25 mL / min. Gradient: 22% to 52% CH ₃ CN in (10 mM NH4HCO3 in H ₂ O) (9 min) then 100% CH3CN (2 min)). LC-MS: m/z = 508.2 [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, CD3OD): 5 = 8.83 (s, 1H), 8.50 (d, J= 8.4 Hz, 1H), 8.13 (d, J = 8.6 Hz, 1H), 7.78 (d, J= 2.1 Hz, 1H), 7.62 (d, J = 8.8 Hz, 1H), 7.00 (dd, J= 2.2, 8.8 Hz, 1H), 6.92 (s, 1H), 4.79 - 4.72 (m, 3H), 4.63 (t, J = 6.2 Hz, 2H), 4.28 (br s, 1H), 3.58 (quin, J = 6.4 Hz, 1H), 2.67 (br s, 2H), 2.39 (s, 3H), 2.12 (br s, 2H), 2.07 - 1.99 (m, 2H), 1.85 - 1.76 (m, 2H), 1.43 (d, J= 6.5 Hz, 3H).

Example 115

1- [3-(l-Hydroxyethyl)-6- [5- [(6-methylpyridazin-3-yl)amino] benzimidazol- 1-yl] -2- pyridyl] pyrazole-3-carbonitrile Step 1: l-(3-acetyl-6-chloro-2-pyridyl)pyrazole-3-carbonitrile

A solution of lH-pyrazole-3-carbonitrile (200 mg, 2.15 mmol, 1 equiv.), l-(6-chloro-2-fluoro-3- pyridyl)ethanone (CAS# 1260663-13-5, 375 mg, 2.16 mmol, 1 equiv.) and DIPEA (840 mg, 6.5 mmol, 3 equiv.) in DMSO (4 mL) was stirred at 30 °C for 16 hours. The reaction mixture was quenched with H2O (30 mL) and extracted with EtOAc (3 x 10 mL). The combined organic layers were dried over Na2SO4, filtered and concentrated under reduced pressure. The residue was purified by preparative TLC (silica gel, 20% EtOAc in petroleum ether, UV detection). The title compound (300 mg, 56.6% yield) was obtained as a white solid. LC-MS: m/z = 247.2 [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, CDCI3): 8 = 8.56 (d, J= 2.7 Hz, 1H), 7.78 (d, J= 7.9 Hz, 1H), 7.43 (d, J= 7.9 Hz, 1H), 6.89 (d, J= 2.7 Hz, 1H), 2.44 (s, 3H).

Step 2: l-[ 3-acetyl-6-[5-[ ( 6-methylpyridazin-3-yl)amino ]benzimidazol-l-yl ]-2-pyridyl Jpyrazole- 3-carbonitrile

Following the procedure described in step 4 of example 113, with N-(6-methylpyridazin-3-yl)- lH-benzimidazol-5-amine (obtained as in intermediate 1 of example 64) (319 mg, 1.42 mmol, 1.2 equiv.), the crude material was obtained and then first purified by preparative HPLC (Phenomenex Luna C18 (150mm x 25mm x 10pm). Flow rate: 25 mL / min. Gradient: 11% to 41% CH3CN in (0.225% formic acid in H2O v/v) (10 min) then 100% CH3CN (2 min)). Additional purifiaction by preparative NPLC (Welch Ultimate XB-CN (250mm x 50mm x 10pm). Flow rate: 100 mL / min. Gradient: 40% to 80% (EtOH with 0.1% NH4OH v/v) in hexane (15 min) then 100% EtOH (5 min)) to give l-[3-acetyl-6-[5-[(6-methylpyridazin-3- yl)amino]benzimidazol-l-yl]-2-pyridyl]pyrazole-3-carbonitril e (80 mg, 15.6% yield) as a brown solid and l-[3-acetyl-6-[6-[(6-methylpyridazin-3-yl)amino]benzimidazol -l-yl]-2- pyridyl]pyrazole-3 -carbonitrile (50 mg, 9.8% yield) as a brown solid. Regioisomer 1 : LC-MS: m/z = 436.3 [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, CD3OD): 5 = 8.99 (s, 1H), 8.83 (d, J = 2.7 Hz, 1H), 8.29 - 8.21 (m, 4H), 8.03 (d, J= 8.3 Hz, 1H), 7.69 (dd, J= 1.7, 8.8 Hz, 1H), 7.37 (d, J = 9.3 Hz, 1H), 7.18 - 7.12 (m, 2H), 2.54 (s, 3H), 2.41 (s, 3H). Regioisomer 2: LC-MS: m/z = 436.3 [M+H] ⁺ , ESI pos. ^X H NMR (400 MHz, CD3OD): 5 = 9.44 (d, J= 2.1 Hz, 1H), 9.18 (d, J = 2.7 Hz, 1H), 8.92 (s, 1H), 8.26 - 8.23 (m, 2H), 8.04 (d, J= 8.2 Hz, 1H), 7.68 (d, J= 8.7 Hz, 1H), 7.39 (d, J= 9.2 Hz, 1H), 7.30 (dd, J= 2.0, 8.7 Hz, 1H), 7.15 (d, J = 9.3 Hz, 1H), 7.08 (d, J= 2.8 Hz, 1H), 2.59 (s, 3H), 2.42 (s, 3H).

Step 3: l-[ 3-( 1 -hydroxyethyl)-6-[5-[ ( 6-methylpyridazin-3-yl)amino ]benzimidazol-l-yl ]-2- pyridyl]pyrazole-3-carbonitrile

Following the procedure described in step 3 of example 107, the title compound (6.9 mg, 8.2% yield) was obtained as a light yellow liophilized solid. Purification by preparative HPLC (Phenomenex Luna C18 (150mm x 25mm x 10pm). Flow rate: 25 mL / min. Gradient: 9% to 39% CH3CN in (0.225% formic acid in H2O v/v) (10 min) then 100% CH3CN (2 min)). LC-MS: m/z = 438.1 [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, CD3OD): 5 = 8.93 (s, 1H), 8.68 (d, J = 2.7 Hz, 1H), 8.54 (d, .7= 8.2 Hz, 1H), 8.23 (d, J= 1.8 Hz, 1H), 8.17 (d, J= 8.9 Hz, 1H), 8.04 (d, J = 8.6 Hz, 1H), 7.64 (dd, J= 1.9, 8.9 Hz, 1H), 7.37 (d, J= 9.3 Hz, 1H), 7.16 - 7.11 (m, 2H), 5.50 (q, J= 6.2 Hz, 1H), 2.54 (s, 3H), 1.51 (d, J= 6.4 Hz, 3H).

Example 116

1- [[[3-(l-Hydroxyethyl)-6- [5- [(6-methylpyridazin-3-yl)amino] benzimidazol-l-yl]-2- pyridyl] amino] methyl] cyclopropanecarbonitrile; formic acid Step 1: l-[[(3-acetyl-6-chloro-2-pyridyl)amino]methyl] cyclopropanecarbonitrile

To a solution of l-(6-chloro-2-fluoro-3-pyridyl)ethanone (CAS# 1260663-13-5, 1.05 g, 6.05 mmol, 1 equiv.), l-(aminomethyl)cyclopropanecarbonitrile hydrochloride (963 mg, 7.26 mmol, 1.2 equiv.) in DMSO (20 mL) was added DIPEA (3 mL, 18.15 mmol, 3 equiv.) stirring was continued at 30 °C for 12 hours. The mixture was poured into H2O (200 mL) and extracted with EtOAc (3 x 100 mL). The combined organic layers wereas washed with brine (3 x 100 mL), dried over Na2SO4, filtered and concentrated in vacuo. The crude title compound (1.5 g, 99.3% yield) was obtained as a yellow solid. LC-MS: m/z = 250.0 [M+H] ⁺ , ESI pos.

Step 2: l-[[[3-acetyl-6-56-[(6-methylpyridazin-3-yl)amino]benzimidaz ol-l-yl]-2- pyridyl amino ] methyl cyclopropanecarbonitrile and !-[[[ 3-acetyl-6-[ 6-[ ( 6-methylpyridazin-3- yl)amino ]benzimidazol-l-yl / -2 -pyridyl amino ] methyl cyclopropanecarbonitrile

Following the procedure described in step 2 of example 115, the crude material was obtained and purified by preparative NPLC (Welch Ultimate XB-SiOH (250mm x 70mm x 10pm). Flow rate: 140 mL / min. Gradient: 20% to 60% (EtOH) in heptane (20 min) then 100% EtOH (3 min)) to give l-[[[3-acetyl-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidaz ol-l-yl]-2- pyridyl]amino]methyl]cyclopropanecarbonitrile (200 mg, 28.5% yield) as a brown solid and 1- [[[3-acetyl-6-[6-[(6-methylpyridazin-3-yl)amino]benzimidazol -l-yl]-2- pyridyl]amino]methyl]cyclopropanecarbonitrile (170 mg, 24.2% yield) as a yellow solid. Regioisomer 1 : LC-MS: m/z = 439.1 [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, DMSO-t/ ₆ ): 8 = 9.56 (t, J= 5.6 Hz, 1H), 9.40 (d, J= 1.9 Hz, 1H), 9.32 (s, 1H), 8.93 (s, 1H), 8.47 (d, J= 8.5 Hz, 1H), 7.67 (d, J= 8.8 Hz, 1H), 7.36 (d, J= 9.1 Hz, 1H), 7.24 (dd, J= 2.0, 8.6 Hz, 1H), 7.19 (d, J = 8.4 Hz, 1H), 7.12 (d, J= 9.1 Hz, 1H), 4.03 - 3.94 (m, 2H), 2.62 (s, 3H), 2.49 - 2.48 (m, 3H), 1.16 - 1.12 (m, 2H), 1.03 - 0.98 (m, 2H). Regioisomer 2: LC-MS: m/z = 439.1 [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, DMSO-t/ ₆ ): 6 = 9.50 (br t, J= 6.1 Hz, 1H), 9.35 (s, 1H), 9.06 (s, 1H), 8.45 (d, J= 8.5 Hz, 1H), 8.38 (d, J= 2.0 Hz, 1H), 8.26 (d, J= 8.9 Hz, 1H), 7.62 (dd, J= 2.0, 8.9 Hz, 1H), 7.37 (d, J= 9.0 Hz, 1H), 7.23 (d, J= 8.5 Hz, 1H), 7.15 (d, J= 9.1 Hz, 1H), 3.88 (d, J= 6.0 Hz, 2H), 2.61 (s, 3H), 2.49 - 2.49 (m, 3H), 1.26 (t, J= 3.0 Hz, 2H), 1.21 - 1.16 (m, 2H), 1.05 (t, J = 7.0 Hz, 1H).

Step 3: l-[[[3-( 1 -hydroxyethyl)-6-[5-[ ( 6-methylpyridazin-3-yl)amino ]benzimidazol-l-yl -2- pyridyl amino ] methyl cyclopropanecarbonitrile; formic acid

Following the procedure described in step 3 of example 107, using a mixture of MeOH (5 mL) and DMF (3 mL) as solvent, the title compound (39.5 mg, 21.8% yield) was obtained as a white liophilized solid. Purification by preparative HPLC (Phenomenex Luna C18 (150mm x 25mm x 10pm). Flow rate: 25 mL / min. Gradient: 6% to 36% CH3CN in (0.225% formic acid in H2O v/v) (10 min) then 100% CH3CN (2 min)). LC-MS: m/z = 441.3 [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, DMSO-t/e): 5 = 9.18 (br s, 1H), 8.82 (s, 1H), 8.36 (d, J= 1.8 Hz, 1H), 8.15 (s, 1H), 8.09 (d, J= 8.8 Hz, 1H), 7.65 (d, J= 7.8 Hz, 1H), 7.52 (dd, J= 1.8, 8.9 Hz, 1H), 7.32 (d, J= 9.0 Hz, 1H), 7.08 (d, J= 9.0 Hz, 1H), 7.03 (d, J = 7.8 Hz, 1H), 6.84 (t, J= 6.0 Hz, 1H), 4.86 (q, J= 6.2 Hz, 1H), 3.74 (br dd, J = 2.4, 5.7 Hz, 2H), 2.47 (s, 3H), 1.40 (d, J= 6.4 Hz, 3H), 1.22 - 1.17 (m, 2H), 1.16 - 1.10 (m, 2H).

Example 117

1- [[[3-(l-Hydroxyethyl)-6- [6- [(6-methylpyridazin-3-yl)amino] benzimidazol-l-yl]-2- pyridyl] amino] methyl] cyclopropanecarbonitrile; formic acid

Following the procedure described in step 3 of example 115, with l-[[[3-acetyl-6-[6-[(6- methylpyridazin-3-yl)amino]benzimidazol-l-yl]-2- pyridyl]amino]methyl]cyclopropanecarbonitrile (obtained in step 2 of example 116) (180 mg, 0.41 mmol, 1 equiv.), the title compound (69 mg, 37% yield) was obtained as a white liophilized solid. Purification by preparative HPLC (Phenomenex Luna C18 (150mm x 25mm x 10pm). Flow rate: 25 mL / min. Gradient: 6% to 36% CH3CN in (0.225% formic acid in H2O v/v) (10 min) then 100% CH3CN (2 min)). LC-MS: m/z = 441.2 [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, DMSO-t/e): 8 = 9.26 (br s, 1H), 9.18 (d, J= 1.8 Hz, 1H), 8.69 (s, 1H), 8.19 (s, 1H), 7.65 (dd, J= 3.4, 8.3 Hz, 2H), 7.33 (d, J = 9.0 Hz, 1H), 7.23 (dd, J= 2.0, 8.7 Hz, 1H), 7.10 (d, J= 9.0 Hz, 1H), 6.98 (d, J = 7.8 Hz, 1H), 6.88 (t, J= 5.7 Hz, 1H), 4.90 (q, J = 6.4 Hz, 1H), 3.86 - 3.74 (m, 2H), 2.48 (s, 3H), 1.43 (d, J= 6.4 Hz, 3H), 1.11 - 1.06 (m, 2H), 1.05 - 0.99 (m, 2H).

Example 118

5- [3-(l-Hydroxyethyl)-6- [5- [(6-methylpyridazin-3-yl)amino] benzimidazol- 1-yl] -2- pyridyl]pyridine-3-carbonitrile; formic acid

Step 1 : 5-[ 3-acetyl-6-[5-[ ( 6-methylpyridazin-3-yl)amino ] benzimidazol- 1-yl / -2 -pyridyl Jpyridine- 3-carbonitrile

Following the procedure described in step 3 of example 76, with 5-cyanopyridine-3-boronic acid (52 mg, 0.35 mmol, 1.2 equiv.), with a reaction time of 3 h, the obtained crude material was purified preparative TLC (silica gel, 10% MeOH in DCM, UV detection). The title compound (110 mg, 84.8% yield) was obtained as a yellow solid. LC-MS: m/z = 447.3 [M+H] ⁺ , ESI pos. Step 2: 5-[ 3-( 1 -hydroxyethyl)-6-[5-[ ( 6-methylpyridazin-3-yl)amino ]benzimidazol-l-yl ]-2- pyridyl]pyridine-3-carbonitrile

Following the procedure described in step 5 of example 113, the title compound (20 mg, 16.3% yield) was obtained as a brown lyophilized solid. Purification by preparative HPLC (Phenomenex Luna C18 (150mm x 25mm x 10pm). Flow rate: 25 mL / min. Gradient: 5% to 35% CH3CN in (0.225% formic acid in H2O v/v) (10 min) then 100% CH3CN (2 min)). LC-MS: m/z = 449.1 [M+H] ⁺ , ESI pos. 'HNMR (400 MHz, DMSO-t/ ₆ ): 8 = 9.21 (s, 1H), 9.17 (br s, 2H), 9.01 (s, 1H), 8.67 (s, 1H), 8.42 (s, 1H), 8.32 (br d, J= 8.6 Hz, 1H), 8.11 (br dd, J= 8.7, 15.5 Hz, 2H), 7.48 (br d, J= 8.4 Hz, 1H), 7.32 (br d, J= 8.9 Hz, 1H), 7.08 (br d, J= 9.0 Hz, 1H), 4.85 -

4.76 (m, 1H), 3.17 (s, 1H), 2.47 (br s, 3H), 1.39 (br d, J= 6.2 Hz, 3H).

Example 119 l-[3-(l-Hydroxyethyl)-6-[5-(l,2,4-triazin-3-ylamino)benzimid azol-l-yl]-2-pyridyl]-5- methyl-pyrazole-3-carbonitrile

Step 1 : l-[ 3-acetyl-6-[5-( 1, 2, 4-triazin-3-ylamino)benzimidazol-l-yl ]-2-pyridyl ]-5-methyl- pyrazole-3-carbonitrile Following the procedure described in step 3 of example 104, with l,2,4-triazin-3-ylamine (23 mg, 0.237 mmol, 2 equiv.), the title compound (56.7 mg, quantitative yield) was obtained as a yellow solid. LC-MS: m/z = 437.3 [M+H] ⁺ , ESI pos.

Step 2: l-[ 3-( 1 -hydroxyethyl)-6-[5-( 1, 2, 4-triazin-3-ylamino)benzimidazol-l-yl ]-2-pyridyl ]-5- methyl-pyrazole-3-carbonitrile

Following the procedure described in step 2 of example 84, the title compound (8.4 mg, 14.5% yield) was obtained as a yellow solid. LC-MS: m/z = 439.2 [M+H] ⁺ , ESI pos.

Example 120 1- [3-(l-Hydroxyethyl)-6- [6- [(6-methylpyridazin-3-yl)amino] benzimidazol-l-yl]-2-pyridyl]-

3-methyl-pyrrolidine-3-carbonitrile

Step 1 : l-(3-acetyl-6-chloro-2-pyridyl)-3-methyl-pyrrolidine-3-carbo nitrile A solution of l-(6-chloro-2-fluoro-3-pyridyl)ethanone (CAS# 1260663-13-5, 400 mg, 2.3 mmol, 1 equiv.), 3-methylpyrrolidine-3-carbonitrile hydrochloride (338 mg, 2.3 mmol, 1 equiv.) and DIPEA (1.14 mL, 6.91 mmol, 3 equiv.) in DMSO (4 mL) was stirred at 100 °C for 3 hours. The reaction mixture was cooled to RT, poured into H2O (10 mL9 and extracted with EtOAc (2 x 10 mL). The combined organic layers were washed with brine (2 x 10 mL) and concentrated to dryness. The crude title compound (300 mg, 98.7% yield) was obtained as a yellow oil. LC-MS: m/z = 264.2 [M+H] ⁺ , ESI pos.

Step 2: l-[ 3-acetyl-6-[5-[ ( 6-methylpyridazin-3-yl)amino ]benzimidazol-l-yl ]-2-pyridyl -3- methyl-pyrrolidine-3-carbonitrile; formic acid and l-[3-acetyl-6-[6-[(6-methylpyridazin-3- yl)amino ]benzimidazol-l-yl / -2 -pyridyl ]-3-methyl-pyrrolidine-3-carbonitrile; formic acid

Following the procedure described in step 4 of example 113, with a reaction time of 16 h at 100 °C, the reaction mixture was cooled to RT, filtered and directly purified by preparative HPLC (Phenomenex Luna C18 (150mm x 40mm x 15pm). Flow rate: 60 mL / min. Gradient: 10% to 40% CH3CN in (0.225% formic acid in H2O v/v) (13 min) then 100% CH3CN (2 min)). A mixture (454 mg) of both title compounds was obtained. This mixture was further purified by preparative NPLC (Welch Ultimate XB-SiOH (250mm x 70mm x 10pm). Flow rate: 140 mL / min. Gradient: 45% to 85% EtOH in hexane (12 min) then 100% EtOH (5 min)) to give l-[3- acetyl-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-l-yl ]-2-pyridyl]-3-methyl-pyrrolidine- 3 -carbonitrile; formic acid (200 mg, 29.1% yield) as a yellow solid and l-[3-acetyl-6-[5-[(6- methylpyridazin-3-yl)amino]benzimidazol-l-yl]-2-pyridyl]-3-m ethyl-pyrrolidine-3-carbonitrile; formic acid (190 mg, 27.7% yield) as a light yellow oil. Regioisomer 1 : LC-MS: m/z = 453.3 [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, CDCI3): 8 = 8.61 - 8.57 (m, 1H), 8.16 - 8.08 (m, 2H), 7.76 - 7.72 (m, 1H), 7.43 - 7.39 (m, 1H), 7.14 (s, 1H), 6.97 - 6.93 (m, 1H), 5.31 (s, 1H), 4.00 - 3.88 (m, 1H), 3.84 - 3.75 (m, 1H), 3.50 - 3.41 (m, 2H), 2.67 - 2.64 (m, 3H), 2.62 - 2.59 (m, 3H), 2.57 - 2.49 (m, 1H), 2.17 - 2.11 (m, 1H), 1.63 - 1.59 (m, 3H). Regioisomer 2: LC-MS: m/z = 453.3 [M+H] ⁺ , ESI pos.

Step 3: l-[ 3-( 1 -hydroxyethyl)-6-[ 6-[ ( 6-methylpyridazin-3-yl)amino ]benzimidazol-l-yl -2- pyridyl]-3-methyl-pyrrolidine-3-carbonitrile

Following the procedure described in step 5 of example 113, the title compound (88.9 mg, 22.1% yield) was obtained as a white lyophilized solid. Purification by preparative HPLC (Waters Xbridge (150mm x 25mm x 5pm). Flow rate: 25 mL / min. Gradient: 27% to 57% CH3CN in (10 mM NH4HCO3 in H ₂ O) (8 min) then 100% CH3CN (2 min)). LC-MS: m/z = 455.2 [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, CDCI3): 6 = 8.54 - 8.47 (m, 1H), 8.42 - 8.35 (m, 1H), 7.96 - 7.89 (m, 1H), 7.75 - 7.68 (m, 1H), 7.66 - 7.38 (m, 1H), 7.22 - 7.17 (m, 1H), 7.16 - 7.12 (m, 1H), 7.10 - 7.05 (m, 1H), 6.98 - 6.92 (m, 1H), 5.23 - 5.14 (m, 1H), 4.13 - 3.86 (m, 1H), 3.78 - 3.56 (m, 2H), 2.64 - 2.57 (m, 3H), 2.49 - 2.41 (m, 1H), 2.05 - 1.99 (m, 1H), 1.61 - 1.53 (m, 3H), 1.52 - 1.47 (m, 3H).

Example 121

1- [3-(l-Hydroxyethyl)-6- [5- [(6-methylpyridazin-3-yl)amino] benzimidazol-l-yl]-2-pyridyl]- 3-methyl-pyrrolidine-3-carbonitrile

Following the procedure described in step 5 of example 113, with l-[3-acetyl-6-[5-[(6- methylpyridazin-3-yl)amino]benzimidazol-l-yl]-2-pyridyl]-3-m ethyl-pyrrolidine-3-carbonitrile (obtained in step 2 of example 120) (150 mg, 0.33 mmol, 1 equiv.), the title compound (52.5 mg, 34.3% yield) was obtained as a white liophilized solid. Purification by preparative HPLC (Waters Xbridge (150mm x 25mm x 5pm). Flow rate: 25 mL / min. Gradient: 27% to 57% CH ₃ CN in (10 mM NH4HCO3 in H ₂ O) (8 min) then 100% CH3CN (2 min)). LC-MS: m/z = 455.3 [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, DMSO-t/ ₆ ): 8 = 9.20 - 9.12 (m, 1H), 8.88 - 8.80 (m, 1H), 8.33 - 8.28 (m, 1H), 8.17 - 8.10 (m, 1H), 8.03 - 7.93 (m, 1H), 7.62 - 7.54 (m, 1H), 7.35 - 7.27 (m, 2H), 7.12 - 7.04 (m, 1H), 5.34 - 5.21 (m, 1H), 5.09 - 5.00 (m, 1H), 4.08 - 3.97 (m, 1H), 3.91 - 3.62 (m, 3H), 2.48 (s, 3H), 2.45 - 2.39 (m, 1H), 2.18 - 2.05 (m, 1H), 1.59 - 1.49 (m, 3H), 1.47 - 1.33 (m, 3H).

Example 122

1- [6- [5- [(6-Methylpyridazin-3-yl)amino] benzimidazol-l-yl]-2-[2-methyl-5- (trifluoromethyl)pyrazol-3-yl] -3-pyridyl] ethanol

Step 1 : l-[ 6-[5-[ ( 6-methylpyridazin-3-yl)amino ]benzimidazol-l-yl ]-2-[ 2-methyl-5- ( trifluoromethyl)pyrazol-3-yl -3-pyridyl ethanone Following the procedure described in step 3 of example 76, with l-methyl-3- (trifluoromethyl)pyrazole-5-boronic acid pinacol ester (41 mg, 0.150 mmol, 1.4 equiv.), the reaction mixture was cooled to RT and filtered. The filter cake was taken in MeOH (30 mL) and the suspension was stirred at 30 °C for 1 hour. The mixture was filtered and the filtrate was concentrated to leave the title compound (35 mg, 67.3% yield) as a yellow solid. LC-MS: m/z = 493.2 [M+H] ⁺ , ESI pos.

Step 2: l-[ 6-[5-[ ( 6-methylpyridazin-3-yl)amino ]benzimidazol-l-yl ]-2-[ 2-methyl-5-

( trifhioromethyl)pyrazol-3-yl / -3-pyridyl ethanol

Following the procedure described in step 5 of example 113, the title compound (2.4 mg, 6.4% yield) was obtained as a white liophilized solid. LC-MS: m/z = 495.2 [M+H] ⁺ , ESI pos. ^J H NMR (400 MHz, CD ₃ OD): 5 = 8.90 (s, 1H), 8.39 (d, J= 8.8 Hz, 1H), 8.24 (d, J= 2.0 Hz, 1H), 8.14 (d, J= 8.8 Hz, 1H), 8.05 (d, J= 8.8 Hz, 1H), 7.64 - 7.55 (m, 1H), 7.35 (d, J= 92 Hz, 1H), 7.13 (d, J

= 92 Hz, 1H), 6.92 (s, 1H), 4.98 - 4.95 (m, 1H), 3.95 (s, 3H), 2.53 (s, 3H), 1.47 (d, J= 6.4 Hz, 3H).

Example 123 l-[3-(l-Hydroxyethyl)-6-[5-(isoxazol-3-ylamino)benzimidazol- l-yl]-2-pyridyl]-5-methyl- pyrazole-3-carbonitrile

Step 1: l-[3-acetyl-6-[5-(isoxazol-3-ylamino)benzimidazol-l-yl]-2-py ridyl]-5-methyl-pyrazole- 3-carbonitrile Following the procedure described in step 3 of example 104, with 3-aminoisoxazole (21 mg, 19 pL, 0.237 mmol, 2 equiv.), the title compound (9.3 mg, 17.2% yield) was obtained as a light yellow solid. LC-MS: m/z = 425.3 [M+H] ⁺ , ESI pos. Step 2: l-[ 3-( 1 -hydroxyethyl)-6-[5-(isoxazol-3-ylamino)benzimidazol-l-yl ]-2-pyridyl ]-5-methyl- pyrazole-3-carbonitrile

Following the procedure described in step 2 of example 84, the title compound (6.1 mg, 65.7% yield) was obtained as a light yellow solid. LC-MS: m/z = 427.2 [M+H] ⁺ , ESI pos.

Example 124 3-(l-Hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino]benzi midazol-l-yl]-N-(2,2,2- trifluoroethyl)pyridine-2-carboxamide; formic acid

Step 1: 3-acetyl-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-l- yl]-N-(2,2,2- trifluoroethyl)pyridine-2-carboxamide

To a suspension of l-[2-chloro-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol -l-yl]-3- pyridyl] ethanone (obtained as in step 2 of example 76) (200 mg, 0.53 mmol, 1 equiv.) in 2,2,2- trifluoroethylamine (3.0 mL, 142.43 mmol, 270 equiv.) and DMF (3 mL) were added dppf (117 mg, 0.21 mmol, 0.4 equiv.), Pd(OAc)2 (24 mg, 0.11 mmol, 0.2 equiv.) and NEt (0.22 mL, 1.58 mmol, 3 equiv.). The reaction mixture was then stirred under CO (50 psi) at 70 °C for 16 hours. The reaction mixture was cooled to RT, poured into H2O (50 mL) and extracted with DCM (4 x 50 mL). The combined organics were washed with brine, dried over Na2SO4, filtered and concentrated in vacuo. The residue was purified by preparative TLC (silica gel, 10% MeOH in DCM, UV detection). The title compound (50 mg, 20.2% yield) was obtained as light brown solid. LC-MS: m/z = 470.3 [M+H] ⁺ , ESI pos.

Step 2: 3-( 1 -hydroxyethyl)-6-[5-[ ( 6-methylpyridazin-3-yl)amino ]benzimidazol-l-yl ]-N-(2, 2, 2- trijluoroethyl)pyridine-2-carboxamide; formic acid

To a solution of 3-acetyl-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-l- yl]-N-(2,2,2- trifluoroethyl)pyridine-2-carboxamide (58 mg, 0.12 mmol, 1 equiv.) in a mixture of MeOH (2 mL) and DMF (2 mL) was added NaBELj (14 mg, 0.37 mmol, 3 equiv.) at 0 °C. The mixture was then stirred at 20 °C for 1 hour. The reaction mixture was directly purified by preparative HPLC: column Phenomenex Luna C18 (150mm x 25mm x 10pm). Flow rate: 25 mL / min. Gradient: 10% to 40% CH3CN in (0.225% formic acid in H2O v/v) (10 min) then 100% CH3CN (2 min). The title compound (9.1 mg, 14.8% yield) was obtained as yellow liophilized solid. LC-MS: m/z = 472.1 [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, CD3OD): 5 = 9.05 (s, 1H), 8.49 (d, J = 8.6 Hz, 1H), 8.24 (d, J= 2.0 Hz, 1H), 8.22 (d, J = 8.9 Hz, 1H), 8.11 (s, 1H), 8.09 (s, 1H), 7.62 (dd, J = 2.1, 8.8 Hz, 1H), 7.59 (d, J= 92 Hz, 1H), 7.38 (d, J= 9.3 Hz, 1H), 5.75 (q, J= 6.3 Hz, 1H), 4.25 - 4.11 (m, 2H), 2.61 (s, 3H), 1.54 (d, = 6.4 Hz, 3H).

Example 125

1- [6- [6- [(6-Methylpyridazin-3-yl)amino] benzimidazol- 1-yl] -2- [(3aR,6aS)-2,3,3a,5,6,6a- hexahydro-lH-pyrrolo[3,2-b]pyrrol-4-yl]-3-pyridyl]ethanol; formic acid Step 1 : rac-trans-l-(3-acetyl-6-chloro-2-pyridyl)-2, 3, 3a, 5, 6, 6a-hexahydropyrrolo[ 3, 2-b ]pyrrole- 4-carboxylate

Following the procedure described in step 4 of example 113, with rac-trans-hexahydro- pyrrolo[3,2-b]pyrrole-l -carboxylic acid tert-butyl ester (856 mg, 4.03 mmol, 1 equiv.), the title compound (1.28 g, 86.1% yield) was obtained as a colorless oil. LC-MS: m/z = 366.1 [M+H] ⁺ , ESI pos.

Step 2: tert-butyl rac-trans-l-[3-acetyl-6-[5-[(6-methylpyridazin-3-yl)amino]be nzimidazol-l- yl]-2-pyridyl]-2,3,3a,5,6,6a-hexahydropyrrolo[3,2-b]pyrrole- 4-carboxylate and tert-butyl rac- trans-l-[ 3-acetyl-6-[ 6-[ ( 6-methylpyridazin-3-yl)amino ]benzimidazol-l-yl / -2 -pyridyl /- 2, 3, 3a, 5, 6, 6a-hexahydropyrrolo[ 3, 2-b ]pyrrole-4-carboxylate

Following the procedure described in step 2 of example 120, with additional reaction time of 6 h at 110 °C, the reaction mixture was cooled to RT, poured into H2O (100 mL) and extracted with DCM (3 x 100 mL). The combined organic extracts were washed with brine, dried over lSfeSCU, filtered and concentrated under vacuum. The residue was purified by preparative HPLC (Phenomenex Luna C18 (250mm x 70mm x 10pm). Flow rate: 140 mL / min. Gradient: 23% to 50% CH3CN in (0.225% formic acid in H2O v/v) (20 min) then 100% CH3CN (5 min)). A mixture of both title compounds (800 mg) was isolated and further purified by preparative NPLC (Welch Ultimate XB-CN (250mm x 70mm x 10pm). Flow rate: 140 mL / min. Gradient: 30% to 70% (EtOH with 0.1% NH4OH v/v) in hexane (12 min) then 100% EtOH (5 min)). To give tertbutyl rac-trans-l-[3-acetyl-6-[5-[(6-methylpyridazin-3-yl)amino]be nzimidazol-l-yl]-2-pyridyl]- 2,3,3a,5,6,6a-hexahydropyrrolo[3,2-b]pyrrole-4-carboxylate (350 mg, 18% yield) as a yellow solid and tert-butyl rac-trans-l-[3-acetyl-6-[6-[(6-methylpyridazin-3-yl)amino]be nzimidazol-l- yl]-2-pyridyl]-2,3,3a,5,6,6a-hexahydropyrrolo[3,2-b]pyrrole- 4-carboxylate (420 mg, 21.6% yield) as a yellow solid.. Regioisomer 1 : LC-MS: m/z = 555.3 [M+H] ⁺ , ESI pos. ^J H NMR (400 MHz, CDC1 ₃ ): 6 = 8.47 (s, 1H), 8.02 (d, J = 8.1 Hz, 1H), 7.92 (d, J = 8.8 Hz, 1H), 7.70 (d, J = 2.0 Hz, 1H), 7.34 - 7.28 (m, 1H), 7.12 - 7.05 (m, 2H), 6.91 (d, J= 8.1 Hz, 1H), 4.12 (dt, J= 6.8, 10.8 Hz, 1H), 3.82 - 3.71 (m, 3H), 3.06 (br dd, J = 8.5, 10.8 Hz, 1H), 2.55 (s, 3H), 2.52 (s, 3H), 2.51 - 2.40 (m, 3H), 2.03 - 1.89 (m, 1H), 1.79 (quin, J= 10.5 Hz, 1H), 1.42 (s, 9H). Regioisomer 2: LC-MS: m/z = 555.3 [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, CDCI3): 8 = 8.74 - 8.59 (m, 1H), 8.36 (s, 1H), 8.00 (d, J= 8.1 Hz, 1H), 7.69 (d, J= 8.6 Hz, 1H), 7.32 - 7.23 (m, 1H), 7.10 - 7.03 (m, 2H), 6.90 (dd, J= 8.7, 10.4 Hz, 2H), 4.08 (dt, J = 6.6, 10.8 Hz, 1H), 3.84 (dt, J = 4.8, 11.0 Hz, 1H), 3.69 - 3.61 (m, 2H), 3.02 (br dd, J= 8.5, 10.8 Hz, 1H), 2.53 (s, 3H), 2.51 (s, 3H), 2.48 - 2.39 (m, 2H), 2.05 - 1.95 (m, 2H), 1.74 - 1.65 (m, 1H), 1.40 (s, 9H).

Step 3: l-[ 6-[ 6-[ ( 6-methylpyridazin-3-yl)amino ]benzimidazol-l-yl ]-2-[rac-trans-2, 3, 3a, 5, 6, 6a- hexahydro-lH-pyrrolo[ 3, 2-b ]pyrrol-4-yl ]-3-pyridyl ethanone

To a solution of tert-butyl rac-trans-l-[3-acetyl-6-[6-[(6-methylpyridazin-3- yl)amino]benzimidazol-l-yl]-2-pyridyl]-2,3,3a,5,6,6a-hexahyd ropyrrolo[3,2-b]pyrrole-4- carboxylate (400 mg, 0.72 mmol, 1 equiv.) in DCM (3 mL) was added TFA (3 mL, 12 mmol, 16.64 equiv.). The reaction mixture was stirred at 20 °C for 1 hour. The reaction mixture was concentrated and the residue was dissolved in DCM (20 mL). The pH of the solution was adjusted to 8 with sat. NaHCCh aq.sol. and the mixture was extracted with DCM / MeOH 9: 1 (9 x). The combined organic layers were dried over Na2SO4, filtered and concentrated to afford the title compound (270 mg, 82.4% yield) as a yellow solid. LC-MS: m/z = 455.3 [M+H] ⁺ , ESI pos.

Step 4: l-[ 6-[ 6-[ ( 6-methylpyridazin-3-yl)amino ]benzimidazol-l-yl ]-2-[ ( 3aR, 6aS)-2, 3, 3a, 5, 6, 6a- hexahydro-lH-pyrrolo[ 3, 2-b ]pyrrol-4-yl ]-3-pyridyl ethanol; formic acid To a solution of l-[6-[6-[(6-methylpyridazin-3-yl)amino]benzimidazol-l-yl]-2- [rac-trans- 2,3,3a,5,6,6a-hexahydro-lH-pyrrolo[3,2-b]pyrrol-4-yl]-3-pyri dyl]ethanone (250 mg, 0.55 mmol, 1 equiv.) in MeOH (3 mL) was added NaBIH (62 mg, 1.65 mmol, 3 equiv.) at 0 °C. The mixture was then stirred at 20 °C for 1 hour. NaBT (62.43 mg, 1.65 mmol, 3 equiv.) was added to the solution. The reaction mixture was stirred at 20 °C for another 1 hour. The mixture was diluted with H2O (30 mL) and extracted with (DCM / MeOH 9: 1) (6 x 30 mL) . The combined organics were dried over Na2SO4, filtered and concentrated. The residue was purified by preparative HPLC (Unisil 3-100 C18 Ultra (150mm x 50mm x 10pm). Flow rate: 25 mL / min. Gradient: 1% to 30% CH3CN in (0.225% formic acid in H2O v/v) (10 min) then 100% CH3CN (2 min)) to give l-[6-[6-[(6-methylpyridazin-3-yl)amino]benzimidazol-l-yl]-2- [(3aR,6aS)- 2,3,3a,5,6,6a-hexahydro-lH-pyrrolo[3,2-b]pyrrol-4-yl]-3-pyri dyl]ethanol; formic acid (32 mg, 12.7% yield) as an off-white liophilized solid and l-[6-[6-[(6-methylpyridazin-3- yl)amino]benzimidazol-l-yl]-2-[(3aS,6aR)-2,3,3a,5,6,6a-hexah ydro-lH-pyrrolo[3,2-b]pyrrol-4- yl]-3-pyridyl]ethanol (71.9 mg, 28.1% yield) as a yellow liophilized solid. Regioisomer 1 : LC- MS: m/z = 457.2 [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, DMSO-t/ ₆ ): 8 = 9.50 (s, 1H), 9.01 (s, 1H), 8.64 (s, 1H), 8.40 (s, 1H), 8.03 (d, J= 8.1 Hz, 1H), 7.67 (d, J= 8.6 Hz, 1H), 7.42 (d, J= 9.1 Hz, 1H), 7.34 (dd, J= 1.8, 8.6 Hz, 1H), 7.27 (d, J= 8.1 Hz, 1H), 7.19 (d, J= 9.1 Hz, 1H), 5.01 (q, J = 6.0 Hz, 1H), 4.40 - 4.25 (m, 2H), 3.81 - 3.76 (m, 1H), 3.56 - 3.48 (m, 3H), 2.49 (s, 3H), 2.30 - 2.22 (m, 1H), 2.20 - 2.05 (m, 2H), 1.51 - 1.39 (m, 1H), 1.32 (d, J = 6.3 Hz, 3H). Regiosimer 2: LC-MS: m/z = 457.2 [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, DMSO-t/ ₆ ): 6 = 9.55 (s, 1H), 8.96 (d, J= 1.4 Hz, 1H), 8.66 (s, 1H), 8.40 (s, 1H), 7.98 (d, J= 8.0 Hz, 1H), 7.67 (d, J= 8.8 Hz, 1H), 7.42 (d, J= 9.1 Hz, 1H), 7.38 (dd, J= 1.7, 8.7 Hz, 1H), 7.33 (d, J = 8.0 Hz, 1H), 7.20 (d, J= 9.1 Hz, 1H), 4.97 (q, J= 6.1 Hz, 1H), 4.43 - 4.30 (m, 2H), 3.84 - 3.79 (m, 1H), 3.62 - 3.51 (m, 3H), 2.49 (s, 3H), 2.30 - 2.22 (m, 1H), 2.19 - 2.10 (m, 2H), 1.56 - 1.46 (m, 4H).

Example 126 l-[6-[6-[(6-Methylpyridazin-3-yl)amino]benzimidazol-l-yl]-2- [(3aS,6aR)-2,3,3a,5,6,6a- hexahydro-lH-pyrrolo[3,2-b]pyrrol-4-yl]-3-pyridyl]ethanol; formic acid The title compound l-[6-[6-[(6-methylpyridazin-3-yl)amino]benzimidazol-l-yl]-2- [(3aS,6aR)- 2,3,3a,5,6,6a-hexahydro-lH-pyrrolo[3,2-b]pyrrol-4-yl]-3-pyri dyl]ethanol (71.9 mg, 28.1% yield) was obtained in step 4 of example 125 (after the purification by preparative HPLC) as a yellow lyophilized solid. LC-MS: m/z = 457.2 [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, DMSO-t/ ₆ ): 8 = 9.55 (s, 1H), 8.96 (d, J= 1.4 Hz, 1H), 8.66 (s, 1H), 8.40 (s, 1H), 7.98 (d, J= 8.0 Hz, 1H), 7.67 (d, J = 8.8 Hz, 1H), 7.42 (d, J= 9.1 Hz, 1H), 7.38 (dd, J= 1.7, 8.7 Hz, 1H), 7.33 (d, J= 8.0 Hz, 1H), 7.20 (d, J= 9.1 Hz, 1H), 4.97 (q, J= 6.1 Hz, 1H), 4.43 - 4.30 (m, 2H), 3.84 - 3.79 (m, 1H), 3.62 - 3.51 (m, 3H), 2.49 (s, 3H), 2.30 - 2.22 (m, 1H), 2.19 - 2.10 (m, 2H), 1.56 - 1.46 (m, 4H).

Example 127

1- [6- [5- [(6-Methylpyridazin-3-yl)amino] benzimidazol-l-yl]-2-[rac-trans-2,3,3a,5,6,6a- hexahydro- IH-pyrrolo [3, 2-b] pyrrol-4-yl] -3-pyridyl] ethanol

Step 1 : l-[ 6-[5-[ ( 6-methylpyridazin-3-yl)amino ]benzimidazol-l-yl ]-2-[rac-trans-2, 3, 3a, 5, 6, 6a- hexahydro- lH-pyrrolo[ 3, 2-b ]pyrrol-4-yl ]-3-pyridyl ] ethanone

Following the procedure described in step 3 of example 125, with tert-butyl rac-trans-l-[3- acetyl-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-l-yl ]-2-pyridyl]-2,3,3a,5,6,6a- hexahydropyrrolo[3,2-b]pyrrole-4-carboxylate (330 mg, 0.59 mmol, 1 equiv.), the title compound (250 mg, 92.4% yield) was obtained as a yellow solid. LC-MS: m/z = 455.3 [M+H] ⁺ , ESI pos. Step 2: l-[ 6-[5-[ ( 6-methylpyridazin-3-yl)amino ]benzimidazol-l-yl ]-2-[rac-trans-2, 3, 3a, 5, 6, 6a- hexahydro-lH-pyrrolo[ 3, 2-b ]pyrrol-4-yl ]-3-pyridyl ethanol

To a solution of l-[6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-l-yl]-2- [rac-trans- 2,3,3a,5,6,6a-hexahydro-lH-pyrrolo[3,2-b]pyrrol-4-yl]-3-pyri dyl]ethanone (230 mg, 0.51 mmol, 1 equiv.) in MeOH (3 mL) was added NaBT (57 mg, 1.52 mmol, 3 equiv.) at 0 °C. The reaction mixture was stirred at 20 °C for 1 hour. DMF (3 mL) and NaBFL (57 mg, 1.52 mmol, 3 equiv.) were added to the mixture which was stirred at RT for another 1 hour. The mixture was diluted with H2O (30 mL) and extracted with (DCM / MeOH 9: 1) (6 x 30 mL) . The combined organics were dried over Na2SO4, filtered and concentrated. The residue was purified by preparative HPLC (Unisil 3-100 C18 Ultra (150mm x 50mm x 10pm). Flow rate: 25 mL / min. Gradient: 1% to 28% CH3CN in (0.225% formic acid in H2O v/v) (10 min) then 100% CH3CN (2 min)). The title compound (137.4 mg, 59.5% yield) as yellow liophilized solid. LC-MS: m/z = 457.2 [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, DMSO-t/ ₆ ): 8 = 9.23 (s, 1H), 8.85 - 8.79 (m, 1H), 8.40 - 8.32 (m, 2H), 8.21 - 8.13 (m, 1H), 8.07 - 7.98 (m, 1H), 7.59 (td, J= 2.4, 8.7 Hz, 1H), 7.48 - 7.37 (m, 1H), 7.34 (d, J = 9.0 Hz, 1H), 7.10 (d, J= 9.0 Hz, 1H), 5.05 - 4.89 (m, 1H), 4.32 - 4.24 (m, 1H), 4.06 (dt, J= 5.9, 10.7 Hz, 1H), 3.76 - 3.70 (m, 2H), 3.65 - 3.49 (m, 2H), 2.49 (s, 3H), 2.31 - 2.22 (m, 1H), 2.14 - 2.02 (m, 2H), 1.61 - 1.25 (m, 4H).

Example 128

1- [2- [3-(Difluoromethyl)-5-methyl-pyrazol- 1-yl] -6- [6- [(6-methylpyridazin-3- yl)amino]benzimidazol-l-yl]-3-pyridyl]ethanol Step 1: l-[6-chloro-2-[3-(difluoromethyl)-5-methyl-pyrazol-l-yl]-3-p yridyl]ethanone and l-[6- chloro-2-[5-(difluoromethyl)-3-methyl-pyrazol-l-yl ]-3-pyridyl ethanone

To a solution of l-(6-chloro-2-fluoro-3-pyridyl)ethanone (CAS# 1260663-13-5, 1.0 g, 5.76 mmol, 1 equiv.) and 3-(difluoromethyl)-5-methyl-lH-pyrazole (837.3 mg, 6.34 mmol, 1.1 equiv.) in DMSO (38 mL) was added K2CO3 (1.19 g, 8.64 mmol, 1.5 equiv.). The reaction mixture was stirred at 65 °C for 2 hours. The mixture was poured into H2O (50 mL) and extracted with EtOAc (3 x 50 mL). The combined organic layers were washed with brine (3 x 50 mL) dried over anhydrous ISfeSCU, filtered and concentrated under vacuum. The residue was purified by flash chromatography (silica gel, 10% EtOAc in PE) to give l-[6-chloro-2-[3- (difhioromethyl)-5-methyl-pyrazol-l-yl]-3-pyridyl]ethanone (885 mg, 3.09 mmol, 53.7% yield) as a white solid and l-[6-chloro-2-[5-(difluoromethyl)-3-methyl-pyrazol-l-yl]-3- pyridyl] ethanone (200 mg, 0.662 mmol, 11.5% yield) as a white solid. Regiosimore 1 : LC-MS: m/z = 286.1 [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, CDCI3): 8 = 7.96 - 7.91 (m, 1H), 7.46 - 7.40 (m, 1H), 6.77 - 6.47 (m, 2H), 2.65 - 2.61 (m, 3H), 2.07 - 2.01 (m, 3H). Regioisomer 2: LC-MS: m/z = 286.1 [M+H] ⁺ , ESI pos. 'H NMR (600 MHz, DMSO-d6) 5 ppm 8.00 - 8.06 (m, 1 H), 7.90 - 7.96 (m, 1 H), 7.37 - 7.58 (m, 2 H), 6.66 (br s, 1 H), 2.25 (s, 3 H), 2.13 (s, 3 H).

Step 2: l-[2-[3-(difluoromethyl)-5-methyl-pyrazol-l-yl]-6-[5-[(6-met hylpyridazin-3- yl)amino ]benzimidazol-l-yl ]-3-pyridyl ethanone and l-[ 2-[ 3-(difluoromethyl)-5-methyl- pyrazol-l-yl] -6- [ 6-[ ( 6-methylpyridazin-3-yl)amino ]benzimidazol-l-yl ]-3-pyridyl ethanone

Following the procedure described in step 4 of example 113, with a reaction time of 16 h at 50 °C, the residue obtained after extraction work-up was purified by preparative NPLC (Welch Ultimate XB-CN (250mm x 50mm x 10pm). Flow rate: 140 mL / min. Gradient: 40% to 80% (EtOH with 0.1% NH4OH v/v) in hexane (12 min) then 100% EtOH (5 min)) to give l-[2-[3- (difhioromethyl)-5-methyl-pyrazol-l-yl]-6-[5-[(6-methylpyrid azin-3-yl)amino]benzimidazol-l- yl]-3-pyridyl]ethanone (300 mg, 22.6% yield) as a light yellow solid (containing traces of l-[2- [5-(difluoromethyl)-3-methyl-pyrazol-l-yl]-6-[5-[(6-methylpy ridazin-3-yl)amino]benzimidazol- 1-yl] -3 -pyridyl] ethanone) and l-[2-[3-(difluoromethyl)-5-methyl-pyrazol-l-yl]-6-[6-[(6- methylpyridazin-3-yl)amino]benzimidazol-l-yl]-3-pyridyl]etha none (300 mg, 22.6% yield) as a light yellow solid. Regioisomer 1 : LC-MS: m/z = 475.1 [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, DMSO-t/e): 8 = 9.29 (s, 1H), 9.09 (s, 1H), 8.46 (d, J= 1.8 Hz, 1H), 8.39 (d, J= 8.4 Hz, 1H), 8.21 (d, J = 8.4 Hz, 1H), 8.17 (d, J = 8.8 Hz, 1H), 7.54 (dd, J = 2.0, 8.9 Hz, 1H), 7.35 (d, J= 9.0 Hz, 1H), 7.11 (d, J = 9.2 Hz, 1H), 7.05 (s, 1H), 6.75 (s, 1H), 2.61 (s, 3H), 2.49 (br s, 3H), 2.01 (s, 3H). Regioisomer 2: LC-MS: m/z = 475.1 [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, DMSO-t/ ₆ ): 6 = 9.31 (s, 1H), 8.97 (s, 1H), 8.86 (d, J= 1.8 Hz, 1H), 8.40 (d, J = 8.3 Hz, 1H), 8.16 (d, J = 8.3 Hz, 1H), 7.71 (d, J= 8.7 Hz, 1H), 7.53 (dd, J = 2.0, 8.7 Hz, 1H), 7.30 (d, J = 92 Hz, 1H), 7.08 (d, J= 9.0 Hz, 1H), 7.03 (s, 1H), 6.69 (s, 1H), 2.60 (s, 3H), 2.47 (s, 3H), 2.00 (s, 3H).

Step 3: l-[ 2-[ 3-(difluoromethyl)-5-methyl-pyrazol-l-yl -6-[ 6-[ ( 6-methylpyridazin-3- yl)amino ]benzimidazol-l-yl ]-3-pyridyl ethanol

Following the procedure described in step 3 of example 107, the title compound (179.2 mg, 61.5% yield) was obtained as a light yellow liophilized solid. Purification by preparative HPLC (Phenomenex Synergi C18 (150mm x 25mm x 10pm). Flow rate: 25 mL / min. Gradient: 8% to 38% CH ₃ CN in (0.225% formic acid in H ₂ O v/v) (10 min) then 100% CH ₃ CN (2 min)). 477.2 [M+H] ⁺ , ESI pos. 'HNMR (400 MHz, CD ₃ OD): 5 = 8.79 (s, 1H), 8.71 (d, J= 1.7 Hz, 1H), 8.53 (d, J = 8.4 Hz, 1H), 8.10 (d, J = 8.4 Hz, 1H), 7.69 (d, J = 8.7 Hz, 1H), 7.45 (dd, J= 2.0, 8.7 Hz, 1H), 7.35 (d, J= 9.2 Hz, 1H), 7.16 (d, J= 92 Hz, 1H), 6.93 - 6.63 (m, 1H), 6.53 (s, 1H), 4.83 (br s, 1H), 2.55 (s, 3H), 2.38 (s, 3H), 1.39 (d, J= 6.5 Hz, 3H). Example 129

1- [2- [3-(Difluoromethyl)-5-methyl-pyrazol- 1-yl] -6- [5- [(6-methylpyridazin-3- yl)amino]benzimidazol-l-yl]-3-pyridyl]ethanol; formic acid Following the procedure described in step 3 of example 107, starting with l-[2-[3- (difluoromethyl)-5-methyl-pyrazol-l-yl]-6-[5-[(6-methylpyrid azin-3-yl)amino]benzimidazol-l- yl]-3-pyridyl]ethanone (obtained in step 2 of example 128) (290 mg, 0.61 mmol, 1 equiv.) the title compound (127 mg, 43.9% yield) was obtained as a light yellow liophilized solid. Purification by preparative HPLC (column Phenomenex Synergi C18 (150mm x 25mm x 10pm). Flow rate: 25 mL / min. Gradient: 9% to 39% CH3CN in (0.225% formic acid in H2O v/v) (10 min) then 100% CH3CN (2 min)). 477.4 [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, CD3OD): 5 = 8.90 (s, 1H), 8.47 (d, J= 8.4 Hz, 1H), 8.21 (d, J = 1.6 Hz, 1H), 8.15 - 8.12 (m, 1H), 8.09 (d, J= 8.4 Hz, 1H), 7.57 (br d, J= 8.8 Hz, 1H), 7.40 (d, J= 9.2 Hz, 1H), 7.18 (d, J= 92 Hz, 1H), 6.95 - 6.65 (m, 1H), 6.58 (s, 1H), 4.83 (q, J = 6.5 Hz, 1H), 2.54 (s, 3H), 2.40 (s, 3H), 1.39 (d, J = 6.5 Hz, 3H).

Example 130 l-[6-[6-Bromo-5-[4-(oxetan-3-yl)piperazin-l-yl]benzimidazol- l-yl]-3-(l-hydroxyethyl)-2- pyridyl]-5-methyl-pyrazole-3-carbonitrile Step 1: 4-bromo-2-nitro-5-[4-(oxetan-3-yl)piperazin-l-yl] aniline

To a solution of 4-bromo-5-fluoro-2-nitro-aniline (0.95 g, 4.04 mmol, 1.0 equiv.) and l-(oxetan- 3-yl)piperazine (0.86 g, 6.06 mmol, 1.5 equiv.) in DMSO (10 mL) was added TEA (1.69 mL, 12.13 mmol, 3.0 equiv.). The reaction mixture was stirred at 50 °C for 16 hours. The reaction mixture was diluted with water and extracted with EtOAc. The organic layers were washed with brine, dried over Na2SO4 and concentrated under vacuum to give 4-bromo-2-nitro-5-[4-(oxetan- 3 -yl)piperazin-l-yl] aniline (1.3 g, 3.64 mmol, 90.0% yield) as yellow solid. LC-MS: m/z = 357.1 [M+H] ⁺ , ESI pos.

Step 2: 4-bromo-5-[ 4-(oxetan-3-yl)piperazin-l-yl Jbenzene-1, 2-diamine

To a solution of 4-bromo-2-nitro-5-[4-(oxetan-3-yl)piperazin-l-yl]aniline (1.0 g, 2.8 mmol, 1.0 equiv.) in EtOH (18 mL) was added Fe° (781.6 mg, 14 mmol, 5.0 equiv.), NH4CI (1.5 g, 28 mmol, 10 equiv.) and water (6 mL). The reaction mixture was stirred under notrogen at 50 °C for 12 hours. The reaction mixture was filtered, the filtrate was concentrated under reduced pressure. The residue was purified by reversed phase chromatography (50% CH3CN in H2O) to yield 4-bromo-5-[4-(oxetan-3-yl)piperazin-l-yl]benzene-l, 2-diamine (500 mg, 1.53 mmol, 54.6% yield) as yellow solid. LC-MS: m/z = 329.0 [M+H] ⁺ , ESI pos.

Step 3: 5-bromo-6-[ 4-(oxetan-3-yl)piperazin-l-yl J-lH-benzimidazole

To a solution of 4-bromo-5-[4-(oxetan-3-yl)piperazin-l-yl]benzene-l, 2-diamine (400.0 mg, 1.22 mmol, 1.0 equiv.) in EtOH (8 mL) was added trimethoxymethane (1.30 g, 12.22 mmol, 10 equiv.) and TsOH (21.1 mg, 0.120 mmol, 0.10 equiv.), and the mixture was stirred at 80 °C for 1 hour. Sat. aq. NaHCCE was added to the reaction to adjust pH to 7 - 8, and the product was extractedwith EtOAc. The combined organic layers were concentrated under vacuum to yield 5- bromo-6-[4-(oxetan-3-yl)piperazin-l-yl]-lH-benzimidazole (400 mg, 1.19 mmol, 97.0% yield) as orange solid. LC-MS: m/z = 339.0 [M+H] ⁺ , ESI pos.

Step 4: l-[ 3-acetyl-6-[ 6-bromo-5-[ 4-(oxetan-3-yl)piperazin-l-yl ] benzimidazol-l-yl ] -2-pyridyl ]- 5-methyl-pyrazole-3-carbonitrile and l-[ 3-acetyl-6-[5-bromo-6-[ 4-(oxetan-3-yl)piperazin-l- yl] benzimidazol-l-yl] -2-pyridyl] -5-methyl-pyrazole-3-carbonitrile

Prepared in analogy to example 64, step 2 using 5-bromo-6-[4-(oxetan-3-yl)piperazin-l-yl]-lH- benzimidazole (400.0 mg, 1.19 mmol, 1.0 equiv.) and l-(3-acetyl-6-chloro-2-pyridyl)-5-methyl- pyrazole-3 -carbonitrile (309.22 mg, 1.19 mmol, 1.0 equiv., prepared in example 64, step 1). The regioisomers were purified by preparative TLC (10% MeOH in DCM) to give l-[3-acetyl-6-[6- bromo-5-[4-(oxetan-3-yl)piperazin-l-yl]benzimidazol-l-yl]-2- pyridyl]-5-methyl-pyrazole-3- carbonitrile (230 mg, 0.410 mmol, 32.81% yield) as yellow solid and l-[3-acetyl-6-[5-bromo-6- [4-(oxetan-3-yl)piperazin-l-yl]benzimidazol-l-yl]-2-pyridyl] -5-methyl-pyrazole-3-carbonitrile (240.9 mg, 0.430 mmol, 34% yield) as orange solid. Regioisomer 1 : LC-MS: m/z = 563.1 [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, DMSO-t/ ₆ ) 5 = 9.13 (s, 1H), 8.60 (d, J = 8.4 Hz, 1H), 8.32 (d, J= 8.4 Hz, 1H), 8.06 (d, J= 11.2 Hz, 2H), 7.16 (s, 1H), 4.60 - 4.54 (m, 2H), 4.49 (t, J = 6.1 Hz, 2H), 3.50 (t, J = 6.4 Hz, 1H), 2.98 (br s, 4H), 2.49 - 2.49 (m, 3H), 2.47 (br s, 4H), 2.28 (s, 3H). Regioisomer 2: LC-MS: m/z = 563.1 [M+H] ⁺ , ESI pos. 'HNMR (400 MHz, DMSO-t/ ₆ ) 5 = 9.19 (s, 1H), 8.55 (d, J= 8.6 Hz, 1H), 8.51 (s, 1H), 8.32 (d, J= 8.6 Hz, 1H), 7.62 (s, 1H), 7.16 (d, J= 0.6 Hz, 1H), 4.59 - 4.55 (m, 2H), 4.51 - 4.46 (m, 2H), 3.50 (quin, J = 6.4 Hz, 1H), 3.03 (br s, 4H), 2.56 (s, 3H), 2.49 - 2.45 (m, 4H), 2.21 (s, 3H).

Step 5: l-[ 6-[ 6-bromo-5-[ 4-(oxetan-3-yl)piperazin-l-yl / benzimidazol-l-yl ]-3-( I -hydr oxy ethyl) - 2-pyridyl] -5-methyl-pyrazole-3-carbonitrile

Prepared in analogy to example 53, step 4 using l-[3-acetyl-6-[6-bromo-5-[4-(oxetan-3- yl)piperazin-l-yl]benzimidazol-l-yl]-2-pyridyl]-5-methyl-pyr azole-3-carbonitrile (200.0 mg, 0.360 mmol, 1.0 equiv.) and NaBEL (40.0 mg, 1.06 mmol, 3.0 equiv.) in MeOH/THF to yield 1- [6-[6-bromo-5-[4-(oxetan-3-yl)piperazin-l-yl]benzimidazol-l- yl]-3-(l-hydroxyethyl)-2-pyridyl]-

5-methyl-pyrazole-3-carbonitrile (143.8 mg, 0.260 mmol, 65.6% yield) as orange solid. LC-MS: m/z = 565.1 [M+H] ⁺ , ESI pos.

Example 133 l-[2-(3-Ethoxy-5-methyl-pyrazol-l-yl)-6-[5-[(6-methylpyridaz in-3-yl)amino]benzimidazol- l-yl]-3-pyridyl]ethanol; formic acid

Step 1 : l-[ 6-chlor o-2-(3-ethoxy-5-methyl-pyr azol- l-yl)-3-pyr idyl ] ethanone

Prepared in analogy to example 64, step 1 using 3-ethoxy-5-methyl-lH-pyrazole (420.0 mg, 3.33 mmol, 1.0 equiv.) and l-(6-chloro-2-fluoro-3-pyridyl)ethanone (CAS# 1260663-13-5, 866.8 mg, 4.99 mmol, 1.5 equiv.) to yield l-[6-chloro-2-(3-ethoxy-5-methyl-pyrazol-l-yl)-3- pyridyl] ethanone (110 mg, 0.390 mmol, 11.8% yield) as orange solid. LC-MS: m/z = 280.1 [M+H] ⁺ , ESI pos. Step 2: l-[2-(3-ethoxy-5-methyl-pyrazol-l-yl)-6-[5-[(6-methylpyridaz in-3- yl)amino ]benzimidazol-l-yl ]-3-pyridyl ethanone and l-[ 2-(3-ethoxy-5-methyl-pyrazol-l-yl)-6- [ 6-[ ( 6-methylpyridazin-3-yl)amino ]benzimidazol-l-yl ]-3-pyridyl ethanone

Prepared in analogy to example 64, step 2 using l-[6-chloro-2-(3-ethoxy-5-methyl-pyrazol-l-yl)- 3 -pyridyl] ethanone (110.0 mg, 0.390 mmol, 1.0 equiv.) and N-(6-methylpyridazin-3-yl)-lH- benzimidazol-5-amine (106.3 mg, 0.470 mmol, 1.2 equiv.) to yield l-[2-(3-ethoxy-5-methyl- pyrazol-l-yl)-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidaz ol-l-yl]-3-pyridyl]ethanone (90 mg, 0.190 mmol, 48.85% yield) as yellow gum. Regioisomer 1 : LC-MS:469.2 [M+H] ⁺ , ESI pos. ^J H NMR (400 MHz, CD ₃ OD) 5 = 8.82 (s, 1H), 8.21 (d, J = 1.8 Hz, 1H), 8.14 (d, J = 8.3 Hz, 1H), 8.09 (d, J= 8.9 Hz, 1H), 7.79 (d, J= 8.2 Hz, 1H), 7.60 (dd, J= 2.1, 8.8 Hz, 1H), 7.35 (d, J = 9.2 Hz, 1H), 7.12 (d, J = 92 Hz, 1H), 5.87 (d, J= 0.6 Hz, 1H), 4.16 (q, J= 7.0 Hz, 2H), 2.60 (s, 3H), 2.53 (s, 3H), 2.17 (s, 3H), 1.37 (t, J = 7.0 Hz, 3H). Regioisomer 2: LC-MS:469.2 [M+H] ⁺ , ESI pos.

Step 3: l-[2-(3-ethoxy-5-methyl-pyrazol-l-yl)-6-[5-[(6-methylpyridaz in-3- yl)amino ]benzimidazol-l-yl ]-3-pyridyl ethanol; formic acid

Prepared in analogy to example 53, step 4 using l-[2-(3-ethoxy-5-methyl-pyrazol-l-yl)-6-[5-[(6- methylpyridazin-3-yl)amino]benzimidazol-l-yl]-3-pyridyl]etha none (90.0 mg, 0.190 mmol, 1.0 equiv.) and NaBH4 (21.8 mg, 0.580 mmol, 3.0 equiv.) to yield l-[2-(3-ethoxy-5-methyl-pyrazol- l-yl)-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-l-yl] -3-pyridyl]ethanol; formic acid (42.3 mg, 0.080 mmol, 46.8% yield) as yellow solid. LC-MS: m/z = 471.2 [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, DMSO-t/ ₆ ) 8 = 9.21 (s, 1H), 8.96 (s, 1H), 8.42 (d, J= 1.9 Hz, 1H), 8.35 (d, J= 8.5 Hz, 1H), 8.18 (s, 1H), 8.08 (dd, J= 6.4, 8.6 Hz, 2H), 7.50 (dd, J= 2.1, 8.9 Hz, 1H), 7.33 (d, J = 9.1 Hz, 1H), 7.08 (d, .7= 9.1 Hz, 1H), 5.86 (s, 1H), 5.66 - 5.17 (m, 1H), 4.96 (br d, J= 6.4 Hz, 1H), 4.16 (q, J= 7.0 Hz, 2H), 2.48 (s, 3H), 2.31 (s, 3H), 1.33 (t, J= 7.0 Hz, 3H), 1.29 (d, J= 6.4 Hz, 3H). Example 134 l-[2-(3-Ethoxy-5-methyl-pyrazol-l-yl)-6-[6-[(6-methylpyridaz in-3-yl)amino]benzimidazol- l-yl]-3-pyridyl] ethanol

Prepared in analogy to example 53, step 4 using l-[2-(3-ethoxy-5-methyl-pyrazol-l-yl)-6-[6-[(6- methylpyridazin-3-yl)amino]benzimidazol-l-yl]-3-pyridyl]etha none (90.0 mg, 0.190 mmol, 1.0 equiv., prepared in example 133, step 2) and NaBH4 (21.8 mg, 0.580 mmol, 3 equivalents to yield l-[2-(3-ethoxy-5-methyl-pyrazol-l-yl)-6-[6-[(6-methylpyridaz in-3-yl)amino]benzimidazol- 1-yl] -3 -pyridyl] ethanol (52.2 mg, 0.110 mmol, 57.8% yield) as yellow solid. LC-MS: m/z = 471.2 [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, DMSO-t/ ₆ ) 8 = 9.28 (s, 1H), 8.78 (s, 1H), 8.65 (d, J = 1.9 Hz, 1H), 8.39 (d, J = 8.4 Hz, 1H), 7.99 (d, J= 8.3 Hz, 1H), 7.69 (d, J= 8.6 Hz, 1H), 7.47

(dd, J= 2.1, 8.7 Hz, 1H), 7.30 (d, J= 9.1 Hz, 1H), 7.08 (d, J = 9.0 Hz, 1H), 5.80 (d, J= 0.6 Hz, 1H), 5.43 (br s, 1H), 4.95 (br d, J= 6.4 Hz, 1H), 4.14 (q, J= 7.0 Hz, 2H), 2.47 (s, 3H), 2.30 (s, 3H), 1.34 - 1.28 (m, 6H).

Example 135

1- [2-(6-Methylpyridazin-4-yl)-6- [5- [(6-methylpyridazin-3-yl)amino] benzimidazol-l-yl]-3- pyridyl] ethanol

Step 1 : l-[2-( 6-methylpyridazin-4-yl)-6-[5-[ ( 6-methylpyridazin-3-yl)amino ]benzimidazol-l-yl ]- 3-pyridyl ethanone l-[2-chloro-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol -l-yl]-3-pyridyl]ethanone (160.0 mg, 0.420 mmol, 1.0 equiv.), 3-methylpyridazine-5-boronic acid, pinacol ester (111.54 mg, 0.510 mmol, 1.2 equiv.), PdCh(dppf) CH2C12 (34.3 mg, 0.042 mmol, 0.1 equiv.) and Na2COs (89 mg, 0.84 mmol, 2 equiv.) were suspended in 1,4-dioxane (1.33 mL) and H2O (0.33 mL). The reaction mixture was heated to 80 °C and stirred for 12 hours. The mixture was cooled to RT, diluted with H2O (7 mL) and EtOAc (7 mL) and stirred for 30 minutes. The insoluble materials were filtered off and the filter cake was washed with 7 mL of EtOAc. The organic layer from the filtrate was washed with brine, dried over anhydrous Na2SO4, filtered and concentrated to leave the crude title compound to yield l-[2-(6-methylpyridazin-4-yl)-6-[5-[(6-methylpyridazin-3- yl)amino]benzimidazol-l-yl]-3-pyridyl]ethanone (140 mg, 0.320 mmol, 75.9% yield) as yellow solid. LC-MS: m/z = 437.1 [M+H] ⁺ , ESI pos.

Step 2: l-[ 2-( 6-methylpyridazin-4-yl)-6-[5-[ ( 6-methylpyridazin-3-yl)amino ]benzimidazol-l-yl ]- 3-pyridyl ethanol

Prepared in analogy to example 53, step 4 using l-[2-(6-methylpyridazin-4-yl)-6-[5-[(6- methylpyridazin-3-yl)amino]benzimidazol-l-yl]-3-pyridyl]etha none (140.0 mg, 0.320 mmol, 1.0 equiv.) and NaBELj in MeOH/DMF (1 : 1) (36.4 mg, 0.960 mmol, 3.0 equiv.) at -40 °C to yield 1- [2-(6-methylpyridazin-4-yl)-6-[5-[(6-methylpyridazin-3-yl)am ino]benzimidazol-l-yl]-3- pyridyl] ethanol (22 mg, 0.050 mmol, 15.6% yield) as yellow solid. LC-MS: m/z = 439.1 [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, CD ₃ OD) 5 = 9.35 (d, J= 1.7 Hz, 1H), 8.90 (s, 1H), 8.38 (d, J = 8.6 Hz, 1H), 8.20 - 8.15 (m, 2H), 8.01 (d, J= 8.6 Hz, 1H), 7.92 (d, J= 2.0 Hz, 1H), 7.53 (dd, J = 2.0, 8.9 Hz, 1H), 7.45 (d, J = 92 Hz, 1H), 7.23 (d, J = 92 Hz, 1H), 4.98 (q, J= 6.4 Hz, 1H), 2.82 (s, 3H), 2.55 (s, 3H), 1.51 (d, J= 6.4 Hz, 3H).

Example 136

4- [3-(l-Hydroxyethyl)-6- [5- [(6-methylpyridazin-3-yl)amino] benzimidazol-l-yl]-2-pyridyl]- l-(2,2,2-trifluoroethyl)piperazin-2-one Step 1: benzyl 3-oxo-4-(2, 2, 2-trifluoroethyl)piper azine- 1 -carboxylate

To a mixture of 2,2,2-trifluoroethyl trifluoromethanesulfonate (3.3 g, 14.09 mmol, 1.1 equiv.) in anhydrous DMF (60 mL) was added NaH (618.0 mg, 15.45 mmol, 1.2 equiv.) under nitrogen at 0 °C and stirred at 0 °C for 30 min. Benzyl 3 -oxopiperazine- 1 -carboxylate (3.0 g, 12.81 mmol, 1.0 equiv.) was added dropwise and the reaction was stirred at RT for 16 hours. The reaction mixture was quenched with aq. sat. NH4CI and extracted with EtOAc. The combined organic layers were concentrated under reduced pressure and purified by preparative HPLC (Phenomenex Luna Cl 8 250 x 80 mm x 10 pm, gradient 35 - 65% CH3CN in H2O (with 0.225% formic acid) over 20 min, then 100% CH3CN (4 min), flow rate 140 mL/min, 1 injection), to yield benzyl 3 -oxo-4-(2,2,2-trifluoroethyl)piperazine-l -carboxylate (1700 mg, 5.37 mmol, 41.97% yield) as colorless oil. LC-MS: m/z = 317.2 [M+H] ⁺ , ESI pos.

Step 2: l-(2,2,2-trifluoroethyl)piperazin-2-one

A mixture of benzyl 3 -oxo-4-(2,2,2-trifluoroethyl)piperazine-l -carboxylate (1.7 g, 5.37 mmol, 1.0 equiv.) and Pd/C (578.0 mg, 0.540 mmol, 0.10 equiv.) in MeOH (30 mL) was hydrogenated under 45 psi of H2 pressure at 30 °C for 16 hours. The suspension was filtered through a pad of Celite and the filter cake was washed with MeOH. The combined filtrates were concentrated to give l-(2,2,2-trifluoroethyl)piperazin-2-one (100 mg, 0.550 mmol, 86.8% yield) as dark green oil. LC-MS: m/z = 183.0 [M+H] ⁺ , ESI pos.

Step 3: 4-[ 3-acetyl-6-[ 6-[ ( 6-methylpyridazin-3-yl)amino ]benzimidazol-l-yl ]-2-pyridyl ]-l-(2, 2, 2- trijluoroethyl)piperazin-2-one and 4-[ 3-acetyl-6-[5-[ ( 6-methylpyridazin-3- yl)amino ]benzimidazol-l-yl ]-2-pyridyl -l-(2, 2, 2 -trifluor oethyl)piper azin-2 -one

A solution of a mixture of l-[2-chloro-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol -l-yl]- 3 -pyridyl] ethanone and l-[2-chloro-6-[6-[(6-methylpyridazin-3-yl)amino]benzimidazol -l-yl]-3- pyridyl] ethanone (200.0 mg, 0.530 mmol, 1 equiv.), l-(2,2,2-trifluoroethyl)piperazin-2-one (164.0 mg, 0.9 mmol, 1.7 equiv.) and DIPEA (205.0 mg, 1.59 mmol, 3.0 equiv.) in DMF (3 mL) was stirred at 30 °C for 16 hours. The reaction mixture was quenched with water and extracted with EtOAc. The combined organic layers were concentrated under reduced pressure and purified by preparative NPLC (Welch Ultimate XB-SiOH 250 mm x 50 mm x 10 pm, gradient 20 - 60% EtOH in hexane over 15 min, then 100% EtOH (3 min), flow rate 100 mL/min) to give 4-[3-acetyl-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol -l-yl]-2-pyridyl]-l-(2,2,2- trifluoroethyl)piperazin-2-one (150 mg, 0.290 mmol, 54.2% yield) as light yellow solid and 4-[3- acetyl-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-l-yl ]-2-pyridyl]-l-(2,2,2- trifluoroethyl)piperazin-2-one (50 mg, 0.100 mmol, 18.1% yield) as light yellow solid. Regioisomer 1 : LC-MS: m/z = 525.4 [M+H] ⁺ , ESI pos. 'HNMR (400 MHz, CDCI3) 8 = 8.60 (s, 1H), 8.21 (d, J= 8.3 Hz, 1H), 8.03 (d, J = 8.9 Hz, 1H), 7.78 (d, J= 1.8 Hz, 1H), 7.44 (dd, J = 1.9, 8.8 Hz, 1H), 7.21 (s, 2H), 7.10 (d, J= 8.3 Hz, 1H), 4.18 - 4.08 (m, 5H), 3.90 - 3.84 (m, 2H), 3.78 - 3.74 (m, 2H), 2.66 (s, 3H), 2.61 (s, 3H). Regioisomer 2: LC-MS: m/z = 525.4 [M+H] ⁺ , ESI pos.

Step 4: 4-[ 3-(l -hydroxyethyl)-6-[5-[ ( 6-methylpyridazin-3-yl)amino ]benzimidazol-l-yl ]-2- pyridyl -l-(2, 2, 2-trifluoroethyl)piperazin-2-one

Prepared in analogy to example 53, step 4 using 4-[3-acetyl-6-[5-[(6-methylpyridazin-3- yl)amino]benzimidazol-l-yl]-2-pyridyl]-l-(2,2,2-trifluoroeth yl)piperazin-2-one (50 mg, 0.100 mmol, 1.0 equiv.) and NaBIH (8.7 mg, 0.231 mmol, 3.0 equiv.) in DCM/MeOH (9: 1) to yield 4- [3-(l-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino]benz imidazol-l-yl]-2-pyridyl]-l- (2,2,2-trifluoroethyl)piperazin-2-one (3.3 mg, 0.006 mmol, 8.22% yield) as light yellow solid. LC-MS: m/z = 527.4 [M+H] ⁺ , ESI pos. ¹ H NMR (400 MHz, CD ₃ OD) 5 = 8.78 (s, 1H), 8.19 (d, J = 1.8 Hz, 1H), 8.17 (d, J = 8.2 Hz, 1H), 8.12 (d, J = 8.8 Hz, 1H), 7.60 (d, J = 4.5 Hz, 1H), 7.60 - 7.57 (m, 1H), 7.38 (d, J = 9.2 Hz, 1H), 7.17 (d, J = 9.2 Hz, 1H), 5.21 (q, J = 6.4 Hz, 1H), 4.22 (d, J = 9.3 Hz, 2H), 4.17 (d, J = 17.0 Hz, 1H), 4.07 - 4.02 (m, 1H), 3.78 - 3.71 (m, 1H), 3.68 - 3.59 (m, 3H), 2.54 (s, 3H), 1.55 (d, J = 6.5 Hz, 3H).

Example 137

4- [3-(l-Hydroxyethyl)-6- [6- [(6-methylpyridazin-3-yl)amino] benzimidazol-l-yl]-2-pyridyl]- l-(2,2,2-trifluoroethyl)piperazin-2-one

Prepared in analogy to example 53, step 4 using 4-[3-acetyl-6-[6-[(6-methylpyridazin-3- yl)amino]benzimidazol-l-yl]-2-pyridyl]-l-(2,2,2-trifluoroeth yl)piperazin-2-one (40.0 mg, 0.080 mmol, 1.0 equiv., prepared in example 136, step 3) and NaBE (9.0 mg, 0.240 mmol, 3.12 equiv.) in DCM/MeOH (9:1) to yield 4-[3-(l-hydroxyethyl)-6-[6-[(6-methylpyridazin-3- yl)amino]benzimidazol-l-yl]-2-pyridyl]-l-(2,2,2-trifluoroeth yl)piperazin-2-one (2.5 mg, 0.005 mmol, 6.23% yield) as light yellow solid. LC-MS: m/z = 527.4 [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, CD ₃ OD) 5 = 9.04 (d, J= 2.0 Hz, 1H), 8.71 (s, 1H), 8.20 (d, J= 8.2 Hz, 1H), 7.64 (dd, J= 8.5, 16.4 Hz, 2H), 7.43 - 7.32 (m, 2H), 7.15 (d, J = 92 Hz, 1H), 5.21 (q, J = 6.6 Hz, 1H), 4.24 - 4.11 (m, 3H), 4.07 - 4.00 (m, 1H), 3.82 - 3.75 (m, 1H), 3.72 - 3.59 (m, 3H), 2.53 (s, 3H), 1.56 (d, J= 6.5 Hz, 3H).

Example 140 l-[3-(l-Hydroxyethyl)-6-[5-methoxy-6-[(6-methylpyridazin-3-y l)amino]benzimidazol-l-yl]- 2-pyridyl]-5-methyl-pyrazole-3-carbonitrile

Step 1: N-(2-methoxy-4, 5-dinitro-phenyl)-6-methyl-pyridazin-3-amine

To a solution of potassium tert-butoxide (488.06 mg, 4.35 mmol, 2.0 equiv.) in DMSO (5 mL) was added 3-amino-6-methylpyridazine (237.33 mg, 2.17 mmol, 1.0 equiv.) and l-fluoro-2- methoxy-4,5-dinitro-benzene (470.0 mg, 2.17 mmol, 1.0 equiv.). Then the brown suspension was stirred at 0 °C for 3 hours. The mixture was purified by silica column (water (0.05% ammonium hydroxide v/v)-CH3CN) (100/0-7/94) to yield N-(2-methoxy-4,5-dinitro-phenyl)-6- methyl-pyridazin-3 -amine (560 mg, 1.83 mmol, 84.36% yield) as light brown solid. LC-MS: m/z = 306.0 [M+H] ⁺ , ESI pos.

Step 2: 6-methoxy-N-( 6-methylpyridazin-3-yl)-lH-benzimidazol-5-amine

To a solution of N-(2-methoxy-4,5-dinitro-phenyl)-6-methyl-pyridazin-3-amine (800.0 mg, 2.62 mmol, 1.0 equiv.) in formic acid (120.62 mg, 2.62 mmol, 1.0 equiv.) was added nickel (101.77 mg, 1.73 mmol, 0.66 equiv.). The mixture was stirred at 30 °C for 16 h under H2 (45 psi). The mixture was filtered and the filtrate was concentrated in vacuo. The resulting residue was treated with MeOH (5 mL), the liquid was collected and concentrated in vacuo. The brown solid was purified by preparative HPLC (Waters Xbridge C18 150 mm x 50 mm x 10 pm, gradient 3 - 33% CH3CN in H2O (with 10 mM NH4CO3) over 11 min, then 100% CH3CN (2 min), flow rate 60 mL/min) to yield 6-methoxy-N-(6-methylpyridazin-3-yl)-lH-benzimidazol-5-amine (200 mg, 0.780 mmol, 29.9% yield) as white solid. LC-MS: m/z = 256.1 [M+H] ⁺ , ESI pos.

Step 3: l-[ 3-acetyl-6-[5-methoxy-6-[ ( 6-methylpyridazin-3-yl)amino ]benzimidazol-l-yl ]-2- pyridyl]-5-methyl-pyrazole-3-carbonitrile

Prepared in analogy to example 64, step 2 using 6-methoxy-N-(6-methylpyridazin-3-yl)-lH- benzimidazol-5-amine (200.0 mg, 0.780 mmol, 1.0 equiv.) and l-(3-acetyl-6-chloro-2-pyridyl)- 5-methyl-pyrazole-3-carbonitrile (245.08 mg, 0.940 mmol, 1.2 equiv., prepared in example 64, step 1). Separation of the isomers by preparative HPLC (Welch Ultimate XB-SiOH 250 mm x 50 mm x 10 pm, gradient 10 - 50% EtOH (with 0.1% ammonium hydroxide) in heptane over 15 min, then 100% EtOH (with 0.1% ammonium hydroxide) for 3 min) yielded l-[3-acetyl-6-[5- methoxy-6-[(6-methylpyridazin-3-yl)amino]benzimidazol-l-yl]- 2-pyridyl]-5-methyl-pyrazole-3- carbonitrile (120 mg, 0.250 mmol, 31.9% yield) as yellow solid and l-[3-acetyl-6-[6-methoxy-5- [(6-methylpyridazin-3-yl)amino]benzimidazol-l-yl]-2-pyridyl] -5-methyl-pyrazole-3-carbonitrile (20 mg, 0.040 mmol, 5.3% yield) as yellow solid. Regioisomer 1 : LC-MS: m/z = 480.1 [M+H] ⁺ , ESI pos. Regioisomer 2: LC-MS: m/z = 480.1 [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, CD3OD) 5 = 2.25 (s, 3 H) 2.58 (d, J= 1.38 Hz, 6 H) 4.01 - 4.06 (m, 3 H) 6.85 (d, J = 0.63 Hz, 1 H) 7.29 - 7.32 (m, 1 H) 7.35 - 7.39 (m, 2 H) 8.11 - 8.17 (m, 1 H) 8.52 (d, J= 8.38 Hz, 1 H) 8.83 (s, 1 H) 9.28 (s, 1 H).

Step 4: l-[3-(l -hydroxyethyl)-6-[5-methoxy-6-[ ( 6-methylpyridazin-3-yl)amino ]benzimidazol-l- y I] -2 -pyridyl ]-5-methyl-pyrazole-3-carbonitrile

Prepared in analogy to example 53, step 4 using l-[3-acetyl-6-[5-methoxy-6-[(6- methylpyridazin-3-yl)amino]benzimidazol-l-yl]-2-pyridyl]-5-m ethyl-pyrazole-3-carbonitrile (100.0 mg, 0.210 mmol, 1.0 equiv.) and NaBE (23.67 mg, 0.630 mmol, 3.0 equiv.) in THF/MeOH (4: 1) to yield l-[3-(l-hydroxyethyl)-6-[5-methoxy-6-[(6-methylpyridazin-3- yl)amino]benzimidazol-l-yl]-2-pyridyl]-5-methyl-pyrazole-3-c arbonitrile (46.8 mg, 0.100 mmol, 46.6% yield) as white solid by lyophilization. LC-MS: m/z = 482.2 [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, CD ₃ OD) 5 ppm 1.44 (d, J = 6.36 Hz, 3 H) 2.40 (s, 3 H) 2.59 (s, 3 H) 4.02 (s, 3 H) 4.74 - 4.83 (m, 1 H) 6.82 (d, J= 0.61 Hz, 1 H) 7.27 - 7.32 (m, 1 H) 7.34 - 7.39 (m, 2 H) 8.16 (d, J= 8.44 Hz, 1 H) 8.55 - 8.60 (m, 1 H) 8.75 - 8.78 (m, 1 H) 9.10 (s, 1 H).

Example 143

1- [6- [5- [(6-Methylpyridazin-3-yl)amino] benzimidazol- 1-yl] -2- [3-methyl- 1-(2,2,2- trifluoroethyl)pyrazol-4-yl] -3-pyridyl] ethanol Step 1: 4-bromo-3-methyl-l-(2,2,2-trifluoroethyl)pyrazole and 4-bromo-5-methyl-l-(2,2,2- trifluoroethyl)pyrazole

A mixture of 4-bromo-3 -methyl pyrazole (15.0 g, 93.17 mmol, 1.0 equiv.), 2,2,2-trifluoroethyl trifluoromethanesulfonate (22.71 g, 97.83 mmol, 1.05 equiv.) and CS2CO3 (25.33 g, 186.34 mmol, 2 equiv.) in DMF (150 mL) was stirred at 100 °C for 12 hours. The reaction mixture was filtered and the filtrate was diluted with H2O and extractedwith EtOAc. The combined organic layers were washed with brine, dried over Na2SO4 and the volatiles removed under reduced pressure. The residue was purified by fish column chromatography (silica gel, 10-16% EtOAc in DCM) to yield a mixture of 4-bromo-5-methyl-l-(2,2,2-trifluoroethyl)pyrazole (6.5 g, 26.75 mmol, 28.7% yield) and 4-bromo-3-methyl-l-(2,2,2-trifluoroethyl)pyrazole (13 g, 53.49 mmol, 57.4% yield) as off-white oil. LC-MS: m/z = 242.9 [M+H] ⁺ , ESI pos.

Step 2: 3-methyl-4-(4, 4, 5, 5-tetramethyl-l, 3, 2-dioxaborolan-2-yl)-l-(2, 2, 2-trifluoroethyl)pyr azole

To a mixture of bis(pinacolato)diboron (17.24 g, 67.9 mmol, 1.5 equiv.) and 4-bromo-3 -methyl- l-(2,2,2-trifhioroethyl)pyrazole (11.0 g, 45.26 mmol, 1.0 equiv.) in 1,4-dioxane (200 mL) was added Pd(dppf)C12-CH2C12 (3.7 g, 4.53 mmol, 0.10 equiv.) and KO Ac (8.9 g, 90.53 mmol, 2.0 equiv.), the mixture was stirred at 100 °C for 16 h under an inert atmosphere. The mixture was concentrated under reduced pressure and purified by flash chromatography (silica gel, 10 - 20% EtOAc in PE) to yield 3-methyl-4-(4, 4, 5, 5-tetramethyl-l, 3, 2-dioxaborolan-2-yl)-l-(2, 2,2- trifhioroethyl)pyrazole (15.1 g, 52.1 mmol, 84.0% yield) as yellow gum. LC-MS: m/z = 291.1 [M+H] ⁺ , ESI pos.

Step 4: l-[ 6-[5-[ ( 6-methylpyridazin-3-yl)amino ]benzimidazol-l-yl -2-[ 3-methyl-l-(2, 2, 2- trijluoroethyl)pyrazol-4-yl]-3-pyridyl ethanone and l-[ 6-[ 6-[ ( 6-methylpyridazin-3- yl)amino ]benzimidazol-l-yl ]-2-[5-methyl-l-(2, 2, 2-trifhioroethyl)pyrazol-4-yl -3- pyridyl ethanone

Prepared in analogy to example 135, step 2 using l-[2-chloro-6-[5-[(6-methylpyridazin-3- yl)amino]benzimidazol-l-yl]-3-pyridyl]ethanone (0.5 g, 1.32 mmol, 1 equiv., prepared in example 76, step 2) and 3-methyl-4-(4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2-yl)-l-( 2,2,2- trifluoroethyl)pyrazole (574.33 mg, 1.98 mmol, 1.5 equiv. ). Purification by SFC (Chiralpak AD- 3 50 mm x 4.6 mm, 3 pm, 40% 'PrOH+CHsCN with 0.05% Et2NH, flow rate 3 mL/min, back pressure 100 bar)) yielded l-[6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-l-yl]-2- [3- methyl-l-(2,2,2-trifluoroethyl)pyrazol-4-yl]-3-pyridyl]ethan one (319 mg, 0.63 mmol, 47.7% yield) as yellow solid and l-[6-[6-[(6-methylpyridazin-3-yl)amino]benzimidazol-l-yl]-2- [5- methyl-l-(2,2,2-trifluoroethyl)pyrazol-4-yl]-3-pyridyl]ethan one (190 mg, 0.376 mmol, 28.5% yield) as yellow solid. LC-MS: m/z = 507.2 [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, CD ₃ OD) 5 = 8.92 (s, 1H), 8.39 - 8.17 (m, 3H), 7.97 (s, 1H), 7.87 (d, J= 8.4 Hz, 1H), 7.68 - 7.57 (m, 1H), 7.35 (d, J= 9.2 Hz, 1H), 7.13 (d, J= 9.2 Hz, 1H), 5.01 - 4.94 (m, 2H), 2.53 (s, 3H), 2.39 (s, 3H), 2.36 (s, 3H).

Step 5: l-[ 6-[5-[ ( 6-methylpyridazin-3-yl)amino ]benzimidazol-l-yl ]-2-[ 3-methyl-l-(2, 2, 2- trijluoroethyl)pyrazol-4-yl]-3-pyridyl ethanol

Prepared in analogy to example 53, step 4 using l-[6-[5-[(6-methylpyridazin-3- yl)amino]benzimidazol-l-yl]-2-[3-methyl-l-(2,2,2-trifluoroet hyl)pyrazol-4-yl]-3- pyridyl] ethanone (750.0 mg, 1.48 mmol, 1.0 equiv.) and NaBIH (281.58 mg, 7.4 mmol, 5 equiv.) at -70 °C to yield l-[6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-l-yl]-2- [3-methyl-l- (2,2,2-trifluoroethyl)pyrazol-4-yl]-3-pyridyl]ethanol (450 mg, 0.880 mmol, 69.0% yield) as yellow solid. LC-MS: m/z = 509.1 [M+H] ⁺ , ESI pos.

Example 144

1- [3-(l-Hydroxyethyl)-6- [6- [(6-methylpyridazin-3-yl)amino] benzimidazol-l-yl]-2-pyridyl]- N,5-dimethyl-pyrazole-3-carboxamide

Step 1: N,5-dimethyl-lH-pyrazole-3-carboxamide

To a stirred solution of 3-methyl-lH-pyrazole-5-carboxylic acid ethyl ester (280 mg, 1.82 mmol, 1.0 equiv.) at RT in MeOH (2 mL) under an argon atmosphere was added methylamine, 41% in water (2.75 g, 3.08 mL, 36.32 mmol, 20 equiv). The mixture was heated to 60 °C and stirring at that temperature was continued overnight. The mixture was cooled to RT and concentrated to dryness to yield N,3-dimethyl-lH-pyrazole-5-carboxamide as white solid, which was used in the next step without further purification. LC-MS: m/z = 140.1 [M+H] ⁺ , ESI pos.

Step 2: l-(3-acetyl-6-chloro-2-pyridyl)-N, 5-dimethyl-pyrazole-3-carboxamide

Prepared in analogy to example 62, step 1 using N,5-dimethyl-lH-pyrazole-3-carboxamide (used as crude from the previous step) and l-(6-chloro-2-fluoro-3-pyridyl)ethanone (296.2 mg, 1.71 mmol, 1.0 equiv.) to yield l-(3-acetyl-6-chloro-2-pyridyl)-N,5-dimethyl-pyrazole-3-carb oxamide (142 mg, 24.7% yield) as bowrn solid. LC-MS: m/z = 293.1 [M+H] ⁺ , ESI pos. Step 3: l-[ 3-acetyl-6-[ 6-[ ( 6-methylpyridazin-3-yl)amino ]benzimidazol-l-yl ]-2-pyridyl ]-N, 5- dimethyl-pyrazole-3-carboxamide and l-[ 3-acetyl-6-[5-[ ( 6-methylpyridazin-3- yl)amino ]benzimidazol-l-yl / -2 -pyridyl -N, 5-dimethyl-pyrazole-3-carboxamide

Prepared in analogy to example 65, step 1 using l-(3-acetyl-6-chloro-2-pyridyl)-N,5-dimethyl- pyrazole-3 -carboxamide (137 mg, 0.407 mmol, 1 equiv.) and lH-benzimidazol-5-yl-(6- methylpyridazin-3-yl)amine (101.91 mg, 0.407 mmol, 1 equiv.) over 8 h to yield l-[3-acetyl-6- [6-[(6-methylpyridazin-3-yl)amino]benzimidazol-l-yl]-2-pyrid yl]-N,5-dimethyl-pyrazole-3- carboxamide (40 mg, 19.6% yield) and l-[3-acetyl-6-[5-[(6-methylpyridazin-3- yl)amino]benzimidazol-l-yl]-2-pyridyl]-N,5-dimethyl-pyrazole -3-carboxamide (33 mg, 15.5% yield) as orange solid after separation of the isomers by flash column chromatography. Regiosisomer 1 : LC-MS: m/z = 482.2 [M+H] ⁺ , ESI pos. 1H NMR (600 MHz, DMSO-t/ ₆ ) d ppm 9.28 (s, 1 H), 9.11 (s, 1 H), 8.46 (d, J = 2.2 Hz, 1 H), 8.44 (d, J = 8.4 Hz, 1 H), 8.24 (d, J = 8.5 Hz, 1 H), 8.17 (d, = 9.1 Hz, 1 H), 7.53 (dd, J= 8.9, 2.2 Hz, 1 H), 7.35 (d, J = 9.1 Hz, 1 H), 7.11 (d, J= 9.1 Hz, 1 H), 6.79 (d, J = 0.8 Hz, 1 H), 2.74 (d, J = 4.7 Hz, 3 H), 2.55 (d, J = 0.8 Hz, 3 H), 2.48 (s, 3 H), 2.04 (s, 3 H) Regioisomer 2: LC-MS: m/z = 482.2 [M+H] ⁺ , ESI pos. 'H NMR (600 MHz, DMSO-t/e) 8 = 9.32 (s, 1 H), 8.98 (s, 1 H), 8.81 (d, J= 2.0 Hz, 1 H), 8.43 - 8.49 (m, 1 H), 8.18 (d, J= 8.5 Hz, 1 H), 8.04 (q, J = 4.7 Hz, 1 H), 7.71 (d, J= 8.7 Hz, 1 H), 7.53 (dd, J = 8.7, 2.1 Hz, 1 H), 7.30 (d, J= 9.1 Hz, 1 H), 7.09 (d, J= 9.1 Hz, 1 H), 6.73 (d, J = 0.9 Hz, 1 H), 2.74 (d, J= 4.7 Hz, 3 H), 2.55 (d, J= 0.7 Hz, 3 H), 2.48 (s, 3 H), 2.04 (s, 3 H).

Step 4: l-[3-(l -hydroxyethyl)-6-[ 6-[ ( 6-methylpyridazin-3-yl)amino ]benzimidazol-l-yl ]-2- pyridyl -N, 5-dimethyl-pyrazole-3-carboxamide Prepared in analogy to example 53, step 4 using l-[3-acetyl-6-[6-[(6-methylpyridazin-3- yl)amino]benzimidazol-l-yl]-2-pyridyl]-N,5-dimethyl-pyrazole -3-carboxamide (37 mg, 0.077 mmol, 1.0 equiv.) in MeOH/THF (1 : 1) to yield l-[3-(l-hydroxyethyl)-6-[6-[(6-methylpyridazin- 3-yl)amino]benzimidazol-l-yl]-2-pyridyl]-N,5-dimethyl-pyrazo le-3-carboxamide (23 mg, 60.7% yield) as light brown solid. LC-MS: m/z = 484.3 [M+H] ⁺ , ESI pos.

Example 145 l-[2-(5-Methyl-3-methylsulfonyl-pyrazol-l-yl)-6-[5-[(6-methy lpyridazin-3- yl)amino]benzimidazol-l-yl]-3-pyridyl]ethanol Step 1: l-[2-(3-bromo-5-methyl-pyrazol-l-yl)-6-chloro-3-pyridyl] ethanone

Prepared in analogy to example 64, step 1 using l-(6-chloro-2-fluoro-3-pyridyl)ethanone (CAS# 1260663-13-5, 2.0 g, 11.52 mmol, 1.0 equiv.) and 3-bromo-5-methyl-lH-pyrazole (1.86 g, 11.52 mmol, 1.0 equiv.) to yield l-[2-(3-bromo-5-methyl-pyrazol-l-yl)-6-chloro-3-pyridyl]etha none (1.8 g, 5.72 mmol, 47.2% yield) as light yellow solid. LC-MS: m/z = 313.9 [M+H] ⁺ and 315.9 [M+H] ⁺ , (bromo isotopes) ESI pos. 'H NMR (400 MHz, CDC1 ₃ ) 8 = 7.91 (d, J = 8.1 Hz, 1H), 7.39 (d, J= 8.1 Hz, 1H), 6.29 (d, J= 0.8 Hz, 1H), 2.60 (d, J= 0.8 Hz, 3H), 2.14 (s, 3H).

Step 2: l-[2-(3-bromo-5-methyl-pyrazol-l-yl)-6-[5-[(6-methylpyridazi n-3- yl)amino ]benzimidazol-l-yl ]-3-pyridyl ethanone

Prepared in analogy to example 64, step 2 using l-[2-(3-bromo-5-methyl-pyrazol-l-yl)-6-chloro- 3 -pyridyl] ethanone (1000.0 mg, 3.18 mmol, 1.0 equiv.) and N-(6-methylpyridazin-3-yl)-lH- benzimidazol-5-amine (716.06 mg, 3.18 mmol, 1.0 equiv., prepared in example 64, intermediate 1) to yield l-[2-(3-bromo-5-methyl-pyrazol-l-yl)-6-[5-[(6-methylpyridazi n-3- yl)amino]benzimidazol-l-yl]-3-pyridyl]ethanone (373 mg, 0.740 mmol, 23.31% yield) as a yellow solid. LC-MS: m/z = 503.1 [M+H] ⁺ and 505.1 [M+H] ⁺ , ESI pos.

Step 3: l-[2-(5-methyl-3-methylsulfonyl-pyrazol-l-yl)-6-[5-[(6-methy lpyridazin-3- yl)amino ]benzimidazol-l-yl ]-3-pyridyl ethanone

A mixture of l-[2-(3-bromo-5-methyl-pyrazol-l-yl)-6-[5-[(6-methylpyridazi n-3- yl)amino]benzimidazol-l-yl]-3-pyridyl]ethanone (378.0 mg, 0.750 mmol, 1.0 equiv.), copper (I) tritiate (23.95 mg, 0.11 mmol, 0.150 equiv.), (lR,2R)-N,N-dimethyl-l,2-cyclohexanediamine (32.05 mg, 0.230 mmol, 0.30 equiv.) and sodium methanesulphinate (115.0 mg, 1.13 mmol, 1.5 equiv.) in DMSO (12 mL) was stirred at 95 °C for 16 h under inert atmosphere. The mixture was filtered and purified by preparative HPLC (formic acid buffer?) to yield l-[2-(5-methyl-3- methylsulfonyl-pyrazol-l-yl)-6-[5-[(6-methylpyridazin-3-yl)a mino]benzimidazol-l-yl]-3- pyridyl] ethanone (168 mg, 0.330 mmol, 43.6% yield) as a yellow solid. LC-MS: m/z = 503.1 [M+H] ⁺ , ESI pos. Step 4: l-[2-(5-methyl-3-methylsulfonyl-pyrazol-l-yl)-6-[5-[(6-methy lpyridazin-3- yl)amino ]benzimidazol-l-yl ]-3-pyridyl ethanol

Prepared in analogy to example 53, step 4 using l-[2-(5-methyl-3-methylsulfonyl-pyrazol-l-yl)- 6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-l-yl]-3-pyr idyl]ethanone (168.0 mg, 0.330 mmol, 1.0 equiv.) and NaBELj (50.0 mg, 1.32 mmol, 3.95 equiv.) in DMF/MeOH (3: 1) to yield l-[2-(5-methyl-3-methylsulfonyl-pyrazol-l-yl)-6-[5-[(6-methy lpyridazin-3- yl)amino]benzimidazol-l-yl]-3-pyridyl]ethanol (66.3 mg, 0.130 mmol, 39.3% yield) as a yellow solid. LC-MS: m/z = 505.1 [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, CD ₃ OD) 5 = 8.94 (s, 1H), 8.53 (d, J= 8.4 Hz, 1H), 8.27 (s, 1H), 8.23 (br s, 1H), 8.19 - 8.13 (t, J= 8.4 Hz, 2H), 7.63 - 7.57

(m, 1H), 7.40 (d, J= 9.2 Hz, 1H), 7.17 (d, J= 8.8 Hz, 1H), 6.91 (s, 1H), 4.81 (q, J= 7.6 Hz, 1H), 3.30 (s, 3H), 2.56 (s, 3H), 2.47 (s, 3H), 1.45 (d, J= 6.4 Hz, 3H).

Example 146 l-[3-(l-Hydroxyethyl)-6-[5-[(2-keto-l-methyl-pyrimidin-4-yl) amino]benzimidazol-l-yl]-2- pyridyl]-5-methyl-pyrazole-3-carbonitrile Step 1: l-[3-acetyl-6-[5-[(2-keto-l-methyl-pyrimidin-4-yl)amino]benz imidazol-l-yl]-2-pyridyl]- 5-methyl-pyrazole-3-carbonitrile

Prepared in analogy to example 104, step 3 using l-[3-acetyl-6-(5-bromobenzimidazol-l-yl)-2- pyridyl]-5-methyl-pyrazole-3-carbonitrile (50 mg, 0.119 mmol, 1.0 equiv., prepared in example 65, step 1) and 4-amino-l-methyl-pyrimidin-2-one (29.7 mg, 0.237 mmol, 2.0 equiv.) to yield the title compound (39.8 mg, 68.4% yield ) as yellow solid. LC-MS: m/z = 466.3 [M+H] ⁺ , ESI pos.

Step 2: l-[ 3-( 1 -hydroxyethyl)-6-[5-[ (2-keto-l-methyl-pyrimidin-4-yl)amino ]benzimidazol-l-yl /- 2 -pyridyl ]-5-methyl-pyrazole-3-carbonitrile

Prepared in analogy to example 53, step 4 using l-[3-acetyl-6-[5-[(2-keto-l-methyl-pyrimidin-4- yl)amino]benzimidazol-l-yl]-2-pyridyl]-5-methyl-pyrazole-3-c arbonitrile (39.8 mg, 0.081 mmol, 1 equiv.) in MeOH/THF to yield the title compound (19.9 mg, 49.8% yield) as light yellow solid. LC-MS: m/z = 468.3 [M+H] ⁺ , ESI pos. Example 148

5-Methyl-l- [6- [5- [(6-methylpyridazin-3-yl)amino] benzimidazol-l-yl]-3-(2,2,2-trifluoro-l- hydroxy-ethyl)-2-pyridyl]pyrazole-3-carbonitrile

Step 1: l-(6-chloro-2-fluoro-3-pyridyl)-2,2,2-trifluoro-ethanone

LDA (4.56 mL, 9.12 mmol, 1.2 equiv.) was added dropwise to a solution of 2-chloro-6- fluoropyridine (1.0 g, 7.6 mmol, 1 equiv.) in THF (20 mL) at -70 °C. A yellow suspension was formed. The mixture was stirred at -70 °C for 1 hour, then N-methoxy-N- methyltrifluoroacetamide (1.26 g, 7.99 mmol, 1.05 equiv.) was added dropwise. After addition, the clear yellow solution was stirred at -70 °C for 1 hour. The mixture was quenched with 100 mL sat. aq. NH4CI, extracted with EtOAc and the organic layers were concentrated under reduced pressure. The residue was purified by flash column choromatography (silica gel, 25% EtOAc in PE) to yield l-(6-chloro-2-fluoro-3-pyridyl)-2,2,2-trifluoro-ethanone (600 mg, 2.64 mmol, 34.7% yield) as light brown oil. LC-MS: m/z = 246.1 [M+H2O+H] , ESI pos.

Step 2: l-[ 6-chloro-3-(2, 2, 2 -trifluoroacetyl) -2 -pyridyl ]-5-methyl-pyrazole-3-carbonitrile

To mixture of l-(6-chloro-2-fluoro-3-pyridyl)-2,2,2-trifluoro-ethanone (6.2 g, 27.25 mmol, 1.0 equiv.) and 5-methyl-lH-pyrazole-3-carbonitrile (2.91 g, 27.21 mmol, 1.0 equiv.) in DMSO (50 mL) was added DIPEA (7.9 mL, 54.5 mmol, 2.0 equiv.) dropwise at 0 °C. After addition, the mixture was stirred at 20 °C for 3 hours. The mixture was quenched with 100 mL water, extracted with 100 mL EtOAc, and the organic layer concentrated under reduced pressure. The residue was purified by reversed phase preparative HPLC (Waters Xbridge BEH C18 150 mm x 50 mm x 10 pm, gradient 30 - 50% CH3CN in H2O (with lOmM NH4HCO3) over 22 min, then 100% CH3CN (5 min), flow rate 140 mL/min) to give l-[6-chloro-3-(2,2,2-trifluoroacetyl)-2- pyridyl]-5-methyl-pyrazole-3-carbonitrile (3.2 g, 10.17 mmol, 37.3% yield) as a pink solid. LC- MS: m/z = 315.1 [M+H] ⁺ , 333.1 [M+H ₂ 0+H] ⁺ ESI pos.

Step 3: 5-methyl-l-[ 6-[5-[ ( 6-methylpyridazin-3-yl)amino ]benzimidazol-l-yl ]-3-(2, 2, 2- trijluoroacetyl)-2-pyridyl] pyrazole-3-carbonitrile ; formic acid and 5-methyl-l-[6-[6-[(6- methylpyridazin-3-yl)amino ]benzimidazol-l-yl ]-3-(2, 2, 2-trijluoroacetyl)-2-pyridyl ]pyrazole-3- carbonitrile ; formic acid

A mixture of l-[6-chloro-3-(2,2,2-trifluoroacetyl)-2-pyridyl]-5-methyl-py razole-3-carbonitrile (0.4 g, 1.27 mmol, 1.0 equiv.), N-(6-methylpyridazin-3-yl)-lH-benzimidazol-5-amine (301.0 mg, 1.34 mmol, 1.05 equiv.) and DIPEA (0.45 mL, 2.54 mmol, 2.0 equiv.) in DMF (10 mL) was stirred at 100 °C for 16 hours. The mixture was purified by preparative HPLC (Shim-pack Cl 8 150 mm x 25mm x 10 pm, gradient 1 - 30% CH3CN in H2O (with 0.225% formic acid) over 10 min, then 100% CH3CN (2 min), flow rate 25 mL/min, 1 injection) to yield 5-methyl-l-[6-[5- [(6-methylpyridazin-3-yl)amino]benzimidazol-l-yl]-3-(2,2,2-t rifluoroacetyl)-2-pyridyl]pyrazole- 3 -carbonitrile; formic acid (170 mg, 26.6% yield) as dark brown solid. LC-MS: m/z = 504.1 [M+H] ⁺ , ESI pos. and 5-methyl-l-[6-[6-[(6-methylpyridazin-3-yl)amino]benzimidazol -l-yl]-3- (2, 2, 2-trifluoroacetyl)-2-pyridyl]pyrazole-3 -carbonitrile; formic acid (120 mg, 18.8% yield) as dark brown solid. LC-MS: m/z = 504.1 [M+H] ⁺ , ESI pos. Step 4: 5-methyl-l-[ 6-[5-[ ( 6-methylpyridazin-3-yl)amino ]benzimidazol-l-yl ]-3-(2, 2, 2-trifluoro- l-hydroxy-ethyl)-2-pyridyl]pyrazole-3-carbonitrile and 5-methyl-l-[ 6-[ 6-[(6-methylpyridazin-3- yl)amino ]benzimidazol-l-yl ]-3-(2, 2, 2-trifluoro-l-hydroxy-ethyl)-2-pyridyl ]pyrazole-3- carbonitrile

Prepared in analogy to example 53, step 3, using 5-methyl-l-[6-[5-[(6-methylpyridazin-3- yl)amino]benzimidazol-l-yl]-3-(2,2,2-trifluoroacetyl)-2-pyri dyl]pyrazole-3-carbonitrile (40.0 mg, 0.080 mmol, 1 equiv.) and NaBIH (8.0 mg, 0.210 mmol, 2.7 equiv.) to yield 5-methyl-l-[6- [5-[(6-methylpyridazin-3-yl)amino]benzimidazol-l-yl]-3-(2,2, 2-trifluoro-l-hydroxy-ethyl)-2- pyridyl]pyrazole-3 -carbonitrile (5.3 mg, 0.010 mmol, 11.9% yield) and 5-methyl-l-[6-[6-[(6- methylpyridazin-3-yl)amino]benzimidazol-l-yl]-3-(2,2,2-trifl uoro-l-hydroxy-ethyl)-2- pyridyl]pyrazole-3 -carbonitrile (1.0 mg, 0.002 mmol, 2.5% yield) as a white solids after purification by preparative HPLC (Waters Xbridge BEH C18 150 mm x 50 mm x 5 pm, gradient 29 - 59% CH ₃ CN in H ₂ O (with lOmM NH4HCO3) over 8 min, then 100% CH3CN (2 min), flow rate 25 mL/min) and separation of the two isomers by preparative NPLC (Welch Ultimate XB- SiOH 250 mm x 50 mm x 10 pm, gradient 10 - 50% EtOH (with 0.1% ammonium hydroxide) in heptane over 15 min, then 100% EtOH (with 0.1% ammonium hydroxide) for 3 min), flow rate 100 mL/min). Regioisomer 1 : LC-MS: m/z = 506.2 [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, CDCI3) 8 = 8.54 - 8.47 (m, 1H), 8.42 - 8.35 (m, 1H), 7.96 - 7.89 (m, 1H), 7.75 - 7.68 (m, 1H), 7.66 - 7.38 (m, 1H), 7.22 - 7.17 (m, 1H), 7.16 - 7.12 (m, 1H), 7.10 - 7.05 (m, 1H), 6.98 - 6.92 (m, 1H), 5.23 - 5.14 (m, 1H), 4.13 - 3.86 (m, 1H), 3.78 - 3.56 (m, 2H), 2.64 - 2.57 (m, 3H), 2.49 - 2.41 (m, 1H), 2.05 - 1.99 (m, 1H), 1.61 - 1.53 (m, 3H), 1.52 - 1.47 (m, 3H). Regioisomer 2: LC-MS: m/z = 506.2 [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, CD3OD) 5 = 8.97 - 8.95 (m, 1H), 8.64 - 8.61 (m, 1H), 8.27 - 8.25 (m, 1H), 8.25 - 8.22 (m, 1H), 8.18 - 8.14 (m, 1H), 7.66 - 7.62 (m, 1H), 7.39 - 7.36 (m, 1H), 7.16 - 7.13 (m, 1H), 6.91 (s, 1H), 5.55 - 5.49 (m, 1H), 2.56 - 2.54 (m, 3H), 2.45 - 2.43 (m, 3H), 2.06 - 2.05 (m, 1H). Example 149

1- [2- [l-(Difluoromethyl)-3-methyl-pyrazol-4-yl]-6- [5- [(6-methylpyridazin-3- yl)amino]benzimidazol-l-yl]-3-pyridyl]ethanol

Step 1: 4-bromo-l-(difluoromethyl)-3-methyl-pyrazole

To a solution of 4-bromo-3 -methyl pyrazole (200.0 mg, 1.24 mmol, 1.0 equiv.) in DMF (5 mL) was added sodium chlorodifluoroacetate (378.8 mg, 2.48 mmol, 2.0 equiv.) and potassium carbonate (515.1 mg, 3.73 mmol, 3.0 equiv.). The mixture was heated to 100 °C for 12 hours. The reaction mixture was then diluted with 20 mL water and extracted with EtOAc. The combined extracts were washed with brine and concentrated under reduced pressure. The residue was purified by flash column chromatography (0-20% EtOAc in PE) to yield 4-bromo-l- (difhioromethyl)-3-methyl-pyrazole (200 mg, 0.950 mmol, 66.4% yield) as a colorless oil. LC- MS: m/z = 213.0 [M+H] ⁺ , ESI pos.

Step 2: l-(difluoromethyl)-3-methyl-4-(4,4,5,5-tetramethyl-l,3,2-dio xaborolan-2-yl)pyrazole

Prepared in analogy to example 143, step 2 using bis(pinacolato)diboron (240.7 mg, 0.950 mmol, 2.0 equiv.) and 4-bromo-l-(difluoromethyl)-3 -methyl -pyrazole (100 mg, 0.474 mmol, 1.0 equiv.) to yield l-(difhioromethyl)-3-methyl-4-(4,4,5,5-tetramethyl-l,3,2-dio xaborolan-2- yl)pyrazole (113 mg, 0.436 mmol, 98.4% yield) as a white crystalline solid. LC-MS: m/z = 259.2 [M+H] ⁺ , ESI pos. Step 3: l-[ 2-[ 1 -(difluor omethyl)-3-methyl-pyrazol-4-yl (-6-[5-[ ( 6-methylpyridazin-3- yl) amino ]benzimidazol-l-yl (-3-pyridyl (ethanone

Prepared in analogy to example 135 Step 2, using of l-[2-chloro-6-[5-[(6-methylpyridazin-3- yl)amino]benzimidazol-l-yl]-3-pyridyl]ethanone (5.0 mg, 0.010 mmol, 1.0 equiv., prepared in example 76, step 2) and l-[2-chloro-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol -l-yl]-3- pyridyl] ethanone (5.0 mg, 0.010 mmol, 1 equiv.) while running the reaction for 2h at 100 °C to yield l-[2-[l-(difluoromethyl)-5-methyl-pyrazol-4-yl]-6-[5-[(6-met hylpyridazin-3- yl)amino]benzimidazol-l-yl]-3-pyridyl]ethanone (12 mg, 0.030 mmol, 7.44% yield). LC-MS: m/z 475.2 [M+H] ⁺ , ESI pos.

Step 4: l-[ 2-[ I -(difluor omethyl)-3-methyl-pyrazol-4-yl ]-6-[5-[ ( 6-methylpyridazin-3- yl) amino ]benzimidazol-l-yl (-3-pyridyl (ethanol

Prepared in analogy to example 53, Step 3, using l-[2-[l-(difluoromethyl)-3-methyl-pyrazol-4- yl]-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-l-yl]-3 -pyridyl]ethanone (20.0 mg, 0.040 mmol, 1.0 equiv.) and NaBEL (4.78 mg, 0.130 mmol, 3 equiv.) to yield l-[2-[l-(difhroromethyl)- 3-methyl-pyrazol-4-yl]-6-[5-[(6-methylpyridazin-3-yl)amino]b enzimidazol-l-yl]-3- pyridyl] ethanol (5.9 mg, 0.010 mmol, 29.4% yield) as a white solid. LC-MS: m/z = 477.1 [M+H] ⁺ , ESI pos. Example 150

1- [3-(l-Hydroxyethyl)-6- [6- [(6-methylpyridazin-3-yl)amino] benzimidazol-l-yl]-2-pyridyl]- 5-methyl-pyrazole-4-carbonitrile

Step 1 : l-(3-acetyl-6-chloro-2-pyridyl)-3-methyl-pyrazole-4-carbonit rile

Prepared in analogy to example 62, step 1 using 5-methyl-lH-pyrazole-4-carbonitrile (616.9 mg, 5.76 mmol, 1.0 equiv.) and l-(6-chloro-2-fluoro-3-pyridyl)ethanone (CAS# 1260663-13-5, 1.0 g, 5.76 mmol, 1.0 equiv.) to yield l-(3-acetyl-6-chloro-2-pyridyl)-3-methyl-pyrazole-4-carbonit rile (900 mg, 3.45 mmol, 59.9% yield) as white solid. LC-MS: m/z = 260.9 [M+H] ⁺ , ESI pos.

Step 2: l-[ 3-acetyl-6-[ 6-[ ( 6-methylpyridazin-3-yl)amino ]benzimidazol-l-yl ]-2-pyridyl ]-5- methyl-pyrazole-4-carbonitrile and l-[3-acetyl-6-[5-[(6-methylpyridazin-3- yl)amino ]benzimidazol-l-yl / -2 -pyridyl ]-5-methyl-pyrazole-4-carbonitrile

Prepared in analogy to example 53, step 3 using l-(3-acetyl-6-chloro-2-pyridyl)-5-methyl- pyrazole-4-carbonitrile (182.0 mg, 0.700 mmol, 1.0 equiv.), N-(6-methylpyridazin-3-yl)-lH- benzimidazol-5-amine (188.72 mg, 0.840 mmol, 1.2 equiv., prepared in example 64, intermediate 1) and DIPEA (0.24 mL, 1.4 mmol, 2 equiv.) to yield l-[3-acetyl-6-[5-[(6- methylpyridazin-3-yl)amino]benzimidazol-l-yl]-2-pyridyl]-5-m ethyl-pyrazole-4-carbonitrile (100 mg, 0.220 mmol, 31.87% yield) as light brown solid and l-[3-acetyl-6-[6-[(6- methylpyridazin-3-yl)amino]benzimidazol-l-yl]-2-pyridyl]-5-m ethyl-pyrazole-4-carbonitrile (60 mg, 0.130 mmol, 19.12% yield) as light brown solid after separation by preparative NPLC (preparative NPLC (Welch Ultimate XB-SiOH 250 mm x 70 mm x 10 pm, gradient 20 - 60% EtOH in hexane over 20 min, then 100% EtOH (3 min), flow rate 140 mL/min). Regiosisomer 1 : LC-MS: m/z = 450.2 [M+H] ⁺ , ESI pos. 'HNMR (400 MHz, CDC1 ₃ ) 8 = 8.62 (s, 1H), 8.32 - 8.25 (m, 1H), 8.03 - 7.97 (m, 1H), 7.94 - 7.91 (m, 1H), 7.87 - 7.82 (m, 1H), 7.78 - 7.72 (m, 1H), 7.50 - 7.44 (m, 1H), 7.21 - 7.16 (m, 1H), 7.15 - 7.09 (m, 1H), 2.79 (s, 3H), 2.62 (s, 3H), 2.24 (s, 3H). Regiosisomer 2: LC-MS: m/z = 450.2 [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, CDCI3) 6 = 8.71 - 8.64 (m, 1H), 8.58 - 8.53 (m, 1H), 8.35 - 8.23 (m, 1H), 7.93 - 7.89 (m, 1H), 7.86 - 7.77 (m, 2H), 7.25 - 7.15 (m, 2H), 7.05 - 6.94 (m, 2H), 2.80 (s, 3H), 2.64 (s, 3H), 2.28 - 2.22 (m, 3H).

Step 3: l-[ 3-( 1 -hydroxyethyl)-6-[ 6-[ ( 6-methylpyridazin-3-yl)amino ]benzimidazol-l-yl ]-2- pyridyl]-5-methyl-pyrazole-4-carbonitrile

Prepared in analogy to example 53, Step 3, using of l-[3-acetyl-6-[6-[(6-methylpyridazin-3- yl)amino]benzimidazol-l-yl]-2-pyridyl]-5-methyl-pyrazole-4-c arbonitrile (60.0 mg, 0.130 mmol, 1.0 equiv.) to yield l-[3-(l-hydroxyethyl)-6-[6-[(6-methylpyridazin-3-yl)amino]be nzimidazol-l- yl]-2-pyridyl]-5-methyl-pyrazole-4-carbonitrile (34.5 mg, 0.080 mmol, 57.24% yield) as an off- white solid after preparative HPLC (Phenomenex Synergi Cl 8 150 x 25mm x 10 pm, gradient 2 - 32% CH3CN in H2O (with 0.225% formic acid) over 10 min, then 100% CH3CN (2 min), flow rate 25 mL/min, 1 injection). LC-MS: m/z = 451.9 [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, CD3OD) 5 = 8.87 - 8.74 (m, 2H), 8.56 - 8.47 (m, 1H), 8.16 - 8.02 (m, 2H), 7.70 - 7.61 (m, 1H), 7.41 - 7.29 (m, 2H), 7.15 - 7.06 (m, 1H), 4.83 - 4.80 (m, 1H), 2.58 - 2.54 (m, 3H), 2.53 - 2.48 (m, 3H), 1.45 - 1.36 (m, 3H)

Example 151

1- [3-(l-Hydroxyethyl)-6- [5- [(6-methylpyridazin-3-yl)amino] benzimidazol-l-yl]-2-pyridyl]- 5-methyl-pyrazole-4-carbonitrile

Prepared in analogy to example 53, Step 3 using l-[3-acetyl-6-[5-[(6-methylpyridazin-3- yl)amino]benzimidazol-l-yl]-2-pyridyl]-5-methyl-pyrazole-4-c arbonitrile (100.0 mg, 0.220 mmol, 1.0 equiv., prepared in example 150, step 2) in CHCh/MeOH (1 : 1) to yield l-[3-(l- hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidaz ol-l-yl]-2-pyridyl]-5-methyl- pyrazole-4-carbonitrile (58.5 mg, 0.130 mmol, 58.24% yield) as yellow solid after preparative HPLC (Phenomenex Synergi C18 150 x 25mm x 10 pm, gradient 3 - 36% CH3CN in H2O (with 0.225% formic acid) over 11 min, then 100% CH3CN (2 min), flow rate 25 mL/min). LC-MS: m/z = 452.0 [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, CD3OD) 5 = 8.87 (s, 1H), 8.51 - 8.44 (m, 1H), 8.24 - 8.18 (m, 1H), 8.13 - 8.04 (m, 3H), 7.59 - 7.54 (m, 1H), 7.40 - 7.34 (m, 1H), 7.17 - 7.10 (m, 1H), 4.82 -4.80 (m, 1H), 2.53 (s, 6H), 1.41 (d, J= 6.5 Hz, 3H).

Example 152

1- [3-(l-Hydroxyethyl)-6- [5- [(6-methylpyridazin-3-yl)amino] benzimidazol-l-yl]-2-pyridyl]- N,5-dimethyl-pyrazole-3-carboxamide

Prepared in analogy to example 55, Step 4, using of l-[3-acetyl-6-[5-[(6-methylpyridazin-3- yl)amino]benzimidazol-l-yl]-2-pyridyl]-N,5-dimethyl-pyrazole -3-carboxamide (30 mg, 0.062 mmol, 1.0 equiv., prepared in example 144, step 3) in MeOH/THF (1 : 1) while stirring overnight to yield to yield the title compound (14 mg, 46% yield) as a light brown solid. LC-MS: m/z = 484.3 [M+H] ⁺ , ESI pos. Example 155 l-[3-(l-Hydroxyethyl)-6-[5-[(2-keto-l-methyl-4-piperidyl)ami no]benzimidazol-l-yl]-2- pyridyl]-5-methyl-pyrazole-3-carbonitrile Step 1: l-[3-acetyl-6-[5-[(2-keto-l-methyl-4-piperidyl)amino]benzimi dazol-l-yl]-2-pyridyl]-5- methyl-pyrazole-3-carbonitrile

Prepared in analogy to example 104, Step 2 with 4-amino-l-methyl-2- piperidone;dihydrochloride (23.87 mg, 0.119 mmol, 2.0 equiv.) for 6 h to afford the title compound (10.7 mg, 36.6% yield) as yellow solid. LC-MS: m/z = 469.3 [M+H] ⁺ , ESI pos.

Step 2: l-[ 3-( 1 -hydroxyethyl)-6-[5-[ (2-keto-l-methyl-4-piperidyl)amino ]benzimidazol-l-yl ]-2- pyridyl]-5-methyl-pyrazole-3-carbonitrile

Prepared in analogy to example 53, step 4 in MeOH/THF (1 :1) to afford the title compound (6.5 mg, 58.7% yield) as yellow solid. LC-MS: m/z = 471.3 [M+H] ⁺ , ESI pos. Example 158 [2-(3-methoxy-5-methyl-pyrazol-l-yl)-6-[5-[(6-methylpyridazi n-3-yl)amino]benzimidazol-l- yl]-3-pyridyl] methanol

Intermediate 1 : N-( 6-methylpyridazin-3-yl)-lH-benzimidazol-5-amine

A mixture of 5-aminobenzimidazole (8.0 g, 60.1 mmol, 1.0 equiv.) and 3-chloro-6- methylpyridazine (7.34 g, 57.08 mmol, 0.950 equiv.) in PrOH (120 mL) was stirred at 120 °C for 72 hours. The dark brown suspension was concentrated in vacuo and the residue was triturated in MeOH (60 mL). The solid was collected by filtration and it was triturated in DCM (40 mL). The product was collected by filtration, washed with DCM and dried. The title compound (10 g, 71.3% yield) was obtained as brown solid. LC-MS: m/z = 226.0 [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, DMSO-t/6): 5 = 9.60 (br s, 1H), 8.72 (s, 1H), 8.52 (d, J = 1.7 Hz, 1H), 7.63 (d, J = 8.8 Hz, 1H), 7.44 (dd, J = 2.0, 8.8 Hz, 1H), 7.39 (d, J = 9.2 Hz, 1H), 7.21 (d, J = 9.2 Hz, 1H), 5.04 - 4.15 (m, 1H), 2.49 (s, 3H).

Step 1: methyl 6-chloro-2-(3-methoxy-5-methyl-pyrazol-l-yl)pyridine-3-carbo xylate

Prepared in analogy to example 133, Step 1 using methyl 6-chloro-2-fluoro-pyridine-3- carboxylate (1.0 g, 5.28 mmol, 1.0 equiv.) and and 3-methoxy-5-methyl-lH-pyrazole (600.0 mg, 5.35 mmol, 1.0 equiv.) to give methyl 6-chloro-2-(3-methoxy-5-methyl-pyrazol-l-yl)pyridine-3- carboxylate (1.4 g, 4.97 mmol, 94.2% yield) as white solid. LC-MS: m/z = 282.2 [M+H] ⁺ , ESI pos. Step 2: methyl 2-(3-methoxy-5-methyl-pyrazol-l-yl)-6-[5-[(6-methylpyridazin -3- yl)amino ]benzimidazol-l-yl ]pyridine-3-carboxylate

A mixture of N-(6-methylpyridazin-3-yl)-lH-benzimidazol-5-amine (0.92 g, 4.07 mmol, 1.04 equiv., intermediate 1), methyl 6-chloro-2-(3-methoxy-5-methyl-pyrazol-l-yl)pyridine-3- carboxylate (1.1 g, 3.91 mmol, 1.0 equiv.) and K2CO3 (1.65 g, 11.94 mmol, 3.1 equiv.) in DMSO (50 mL) was stirred at 50 °C for 12 hours. The mixture was cooled to RT and poured into H2O (500 mL). A solid precipitated out. This was extracted with EtOAc (3 x 400 mL). The combined organic layers were concentrated. The residue was purified by preparative HPLC: column Phenomenex Luna C18 (250mm x 70 mm x 15pm. Flow rate 140 mL / min. Gradient: 20% to 50% CH3CN in (H2O with 0.225% formic acid v/v) (35 min) then 100% CH3CN (1 min). A mixture of methyl 2-(3-methoxy-5-methyl-pyrazol-l-yl)-6-[6-[(6-methylpyridazin -3- yl)amino]benzimidazol-l-yl]pyridine-3-carboxylate (370 mg, 0.79 mmol, 20.1% yield) and methyl 2-(3-methoxy-5-methyl-pyrazol-l-yl)-6-[5-[(6-methylpyridazin -3- yl)amino]benzimidazol-l-yl]pyridine-3-carboxylate (350 mg, 0.74 mmol, 18.1% yield) as light yellow solids was obtained. LC-MS: m/z = 471.1 [M+H] ⁺ , ESI pos. This mixture was purified by preparative NPLC: column Welch Ultimate XB-SiOH (250mm x 70mm x lOum). Flow rate 140 mL / min. Gradient: 20% to 60% EtOH in hexane (20 min) then 100% EtOH (3 min).

Step 3: [2-(3-methoxy-5-methyl-pyrazol-l-yl)-6-[5-[(6-methylpyridazi n-3- yl)amino ]benzimidazol-l-yl ]-3-pyridyl methanol

A solution of methyl 2-(3-methoxy-5-methyl-pyrazol-l-yl)-6-[5-[(6-methylpyridazin -3- yl)amino]benzimidazol-l-yl]pyridine-3-carboxylate (30.0 mg, 0.060 mmol, 1.0 equiv.) in DCM (4 mL) was added DIBAL-H (0.14 mL, 0.140 mmol, 2.2 equiv.) at -76 °C over 5 min. The mixture was stirred at -76 °C for 1 hour. Another portion of DIBAL-H (0.14 mL, 0.140 mmol, 2.2 equiv.) was added after 2 hours and 4 hours at - 76 °C, and the reaction mixture stirred for another hour at this temperature. Then the reaction mixture was diluted with 5 mL THF and warmed to 0 °C, the reaction mixture was quenched by addition of 0.16 mL of H2O, followed by 0.16 mL of 15% aq. NaOH and 0.4 mL H2O in this order. After being stirred at RT for 15 min, the MgSCU was added to the reaction mixture which was stirred at RT for 15 min. After filtration, the volatiles were removed under reduced pressure. The residue was purified by preparative TLC (silica gel, 9% MeOH in DCM) to give [2-(3-methoxy-5-methyl-pyrazol-l-yl)- 6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-l-yl]-3-pyr idyl]methanol (20 mg, 0.050 mmol, 68.8% yield) as light yellow solid. LC-MS: m/z = 443.1 [M+H] ⁺ , ESI pos. 'HNMR (400 MHz, CD3OD): 5 = 8.84 (s, 1H), 8.34 (d, J = 8.3 Hz, 1H), 8.21 (d, J = 2.0 Hz, 1H), 8.13 (d, J = 8.9 Hz, 1H), 7.92 (d, J = 8.3 Hz, 1H), 7.61 (dd, J = 2.1, 8.9 Hz, 1H), 7.35 (d, J = 9.1 Hz, 1H), 7.13 (d, J = 9.1 Hz, 1H), 5.85 (s, 1H), 4.69 (s, 2H), 3.90 (s, 3H), 2.53 (s, 3H), 2.41 (s, 3H).

Example 159

1- [2-(3,5-Dimethylisoxazol-4-yl)-6- [5- [(6-methylpyridazin-3-yl)amino] benzimidazol- 1-yl] -3- pyridyl] ethanol

Step 1 : l-[ 2-(3, 5-dimethylisoxazol-4-yl)-6-[5-[ ( 6-methylpyridazin-3-yl)amino ] benzimidazol- 1- yl] -3-pyridyl ethanone Prepared in analogy to example 143, step 2 using (3,5-dimethylisoxazol-4-yl)boronic acid (26.0 mg, 0.180 mmol, 1.4 equiv.) and of l-[2-chloro-6-[5-[(6-methylpyridazin-3- yl)amino]benzimidazol-l-yl]-3-pyridyl]ethanone (50.0 mg, 0.130 mmol, 1.0 equiv., prepared in example 76, step 2) to give l-[2-(3,5-dimethylisoxazol-4-yl)-6-[5-[(6-methylpyridazin-3- yl)amino]benzimidazol-l-yl]-3-pyridyl]ethanone (25 mg, 0.060 mmol, 43.1% yield) as yellow solid. LC-MS: 440.2 [M+H] ⁺ , ESI pos.

Step 2: l-[2-(3,5-dimethylisoxazol-4-yl)-6-[5-[(6-methylpyridazin-3- yl)amino]benzimidazol-l- yl] -3-pyridyl ethanol Prepared in analogy to example 53, step 4 to yield l-[2-(3,5-dimethylisoxazol-4-yl)-6-[5-[(6- methylpyridazin-3-yl)amino]benzimidazol-l-yl]-3-pyridyl]etha nol (9.8 mg, 0.020 mmol, 39.0% yield) as white solid. Lc-MS: m/z = 442.2 [M+H] ⁺ , ESI pos.

Example 160

1- [3-(l-Hydroxyethyl)-6- [5- [(4-methoxypyridazin-3-yl)amino] benzimidazol- 1-yl] -2- pyridyl]-5-methyl-pyrazole-3-carbonitrile Step 1 : l-[ 3-acetyl-6-[5-[ ( 4-methoxypyridazin-3-yl)amino ]benzimidazol-l-yl / -2 -pyridyl ]-5- methyl-pyrazole-3-carbonitrile

Was prepared in analogy to example 104, step 2 using (4-methoxypyridazin-3-yl)amine (23.76 mg, 0.190 mmol, 2.0 equiv.) to yield the title compound (29.6 mg, 63.6% yield) as yellow solid.

LC-MS: 466.3 [M+H] ⁺ , ESI pos.

Step 2: l-[3-(l-hydroxyethyl)-6-[5-[(4-methoxypyridazin-3-yl)amino]b enzimidazol-l-yl]-2- pyridyl]-5-methyl-pyrazole-3-carbonitrile In analogy to example 53, step 4, in MeOH/THF (1 : 1) the title compound (18.9 mg, 63.6% yield) was obtained as light yellow solid. LC-MS: 468.3 [M+H] ⁺ , ESI pos.

Example 161 l-[3-(l-Hydroxyethyl)-6-[5-[(5-keto-l-methyl-pyrrolidin-3-yl )amino]benzimidazol-l-yl]-2- pyridyl]-5-methyl-pyrazole-3-carbonitrile Step 1: l-[3-acetyl-6-[5-[(5-keto-l-methyl-pyrrolidin-3-yl)amino]ben zimidazol-l-yl]-2-pyridyl]- 5-methyl-pyrazole-3-carbonitrile

Was prepared in analogy to example 104, step 2 using 4-amino-l-m ethyl -2-pyrrolidone (27.1 mg, 0.237 mmol, 2 equiv.) to yield the title compound (43.1 mg, 75.9% yield). LC-MS: 455.3 [M+H] ⁺ , ESI pos.

Step 2: l-[ 3-( 1 -hydroxyethyl)-6-[5-[ (5-keto-l-methyl-pyrrolidin-3-yl)amino ]benzimidazol-l-yl ]- 2-pyridyl]-5-methyl-pyrazole-3-carbonitrile In analogy to example 53, step 4, in MeOH/THF (1 : 1) the title compound (36.7 mg, 81.4% yield) was obtained as yellow solid. LC-MS: 457.3 [M+H] ⁺ , ESI pos.

Example 162

1- [6- [5- [(6-Methylpyridazin-3-yl)amino] benzimidazol- 1-yl] -2-(3-methyl-4-pyridyl)-3- pyridyl] ethanol Step 1 : l-[ 6-[5-[ ( 6-methylpyridazin-3-yl)amino ]benzimidazol-l-yl / -2-(3-methyl-4-pyridyl)-3- pyridyl ethanone

Prepared in analogy to example 143, step 2 using 3-methylpyridine-4-boronic acid (36.15 mg, 0.260 mmol, 2 equiv.) and of l-[2-chloro-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol -l- yl]-3-pyridyl]ethanone (50.0 mg, 0.130 mmol, 1.0 equiv., prepared in example 76, step 2) to give l-[6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-l-yl]-2- (3-methyl-4-pyridyl)-3- pyridyl] ethanone (22 mg, 0.050 mmol, 38.28% yield) as a yellow solid. LC-MS: m/z = 436.2, [M+H] ⁺ , ESI pos. Step 2: l-[6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-l-yl]-2- (3-methyl-4-pyridyl)-3- pyridyl ethanol

In analogy to example 53, step 4, using 5.0 equivalents of NaBEL, l-[6-[5-[(6-methylpyridazin- 3-yl)amino]benzimidazol-l-yl]-2-(3-methyl-4-pyridyl)-3-pyrid yl]ethanol (8.9 mg, 0.020 mmol, 44.3% yield) was obtained as a white solid. LC-MS: m/z = 438.2, [M+H] ⁺ , ESI pos. Example 163 l-[2-[4-(Cyclopropylamino)pyrimidin-5-yl]-6-[5-[(6-methylpyr idazin-3- yl)amino]benzimidazol-l-yl]-3-pyridyl]ethanol Step 1: [4-(cyclopropylamino)pyrimidin-5-yl]boronic acid

Prepared in analogy to example 143, step 2 using 5-bromo-N-cyclopropyl-pyrimidin-4-amine (1.0 g, 4.67 mmol, 1.0 equiv.) and bis(pinacolato)diboron (1779.45 mg, 7.01 mmol, 1.5 equiv.) to yield [4-(cyclopropylamino)pyrimidin-5-yl]boronic acid (368 mg, 2.06 mmol, 44.0% yield) as white solid. LC-MS: m/z = 180.1, [M+H] ⁺ , ESI pos.

Step 2: l-[2-chloro-6-[5-[ ( 6-methylpyridazin-3-yl)amino ]benzimidazol-l-yl ]-3-pyridyl ethanol

In analogy to example 53, step 4 using l-[2-chloro-6-[5-[(6-methylpyridazin-3- yl)amino]benzimidazol-l-yl]-3-pyridyl]ethanone (200.0 mg, 0.530 mmol, 1.0 equiv. prepared in example 76, step 2) and 5.0 equivalents of NaBH4 l-[2-chloro-6-[5-[(6-methylpyridazin-3- yl)amino]benzimidazol-l-yl]-3-pyridyl]ethanol (130 mg, 0.340 mmol, 51.7% yield) was obtained as a grey solid. LC-MS: m/z = 381.1, [M+H] ⁺ , ESI pos. Step 3: l-[2-[4-(cyclopropylamino)pyrimidin-5-yl]-6-[5-[(6-methylpyr idazin-3- yl)amino ]benzimidazol-l-yl ]-3-pyridyl ethanol

In analogy to example 143, step 2 using l-[2-chloro-6-[5-[(6-methylpyridazin-3- yl)amino]benzimidazol-l-yl]-3-pyridyl]ethanol (30.0 mg, 0.080 mmol, 1.0 equiv. from Example 163, step 2) and [4-(cyclopropylamino)pyrimidin-5-yl]boronic acid (42.3 mg, 0.240 mmol, 3.0 equiv. from Example 163, step 1), l-[2-[4-(cyclopropylamino)pyrimidin-5-yl]-6-[5-[(6- methylpyridazin-3-yl)amino]benzimidazol-l-yl]-3-pyridyl]etha nol (4 mg, 0.010 mmol, 10.5% yield) was obtained as white solid. LC-MS: m/z = 480.1, [M+H] ⁺ , ESI pos.

Example 164

5- [3-(l-Hydroxyethyl)-6- [5- [(6-methylpyridazin-3-yl)amino] benzimidazol-l-yl]-2-pyridyl]- 4-(trifluoromethyl)pyridin-2-ol

Step 1: 5-bromo-2-methoxy-4-(trifluoromethyl)pyridine

A solution of 5-bromo-2-chloro-4-(trifluoromethyl)pyridine (1.0 g, 3.84 mmol, 1.0 equiv.) and methoxysodium (0.41 g, 7.68 mmol, 2 equiv.) in methanol (7 mL) was stirred at 70 °C for 2 hour. The reaction mixture was dissolved in DCM (10 mL) and filtered, the filtrate was concentrated in vacuum to give the desired product as white solid, which was used without further purification. LC-MS: m/z = 257.9, [M+H] ⁺ , ESI pos. Step 2: 2-methoxy-5-(4, 4, 5,5-tetramethyl-l, 3, 2-dioxaborolan-2-yl)-4-(trijluoromethyl)pyridine

Prepared in analogy to example 143, step 2 3 -bromo-6-methoxy-2-(trifluorom ethyl )pyri dine (used as crude from the previous step) to provide the desied compound as an off-white solid (400 mg, 62.7% yield). LC-MS: m/z = 304.1, [M+H] ⁺ , ESI pos.

Step 3: l-[2-[6-methoxy-4-(trijluoromethyl)-3-pyridyl]-6-[5-[(6-meth ylpyridazin-3- yl)amino ]benzimidazol-l-yl ]-3-pyridyl ethanone

Prepared in analogy to example 143, step 2 using 2-methoxy-5-(4,4,5,5-tetramethyl-l,3,2- dioxaborolan-2-yl)-4-(trifluoromethyl)pyridine (240.03 mg, 0.790 mmol, 3 equiv.) and l-[2- chloro-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-l-yl ]-3-pyridyl]ethanone (100.0 mg, 0.260 mmol, 1.0 equiv., prepared in example 76, step 2) to give l-[2-[6-methoxy-4- (trifluoromethyl)-3-pyridyl]-6-[5-[(6-methylpyridazin-3-yl)a mino]benzimidazol-l-yl]-3- pyridyl] ethanone (45 mg, 0.090 mmol, 32.82% yield) as yellow solid. LC-MS: m/z = 520.2, [M+H] ⁺ , ESI pos.

Step 4: l-[ 2-[ 6-hydroxy-4-( trifhioromethyl)-3-pyridyl ]-6-[5-[ ( 6-methylpyridazin-3- yl)amino ]benzimidazol-l-yl ]-3-pyridyl ethanone; formic acid

To a solution of l-[2-[6-methoxy-4-(trifluoromethyl)-3-pyridyl]-6-[5-[(6-meth ylpyridazin-3- yl)amino]benzimidazol-l-yl]-3-pyridyl]ethanone (40.0 mg, 0.080 mmol, 1.0 equiv.) in HC1 (2008.86 mg, 3 mmol, 39.0 equiv.) and the resulting mixture was stirred at 100 °C for 3 hours. The reaction mixture was concentrated under reduced pressure. The residue was purified by preparative HPLC (Phenomenex Luna C18 (150mm x 40mm x 15pm). Flow rate: 60 mL / min. Gradient: 10% to 40% CH3CN in (0.225% formic acid in H2O v/v) (13 min) then 100% CH3CN (2 min)) and lyophilized to yield l-[2-[6-hydroxy-4-(trifluoromethyl)-3-pyridyl]-6-[5-[(6- methylpyridazin-3-yl)amino]benzimidazol-l-yl]-3-pyridyl]etha none; formic acid (30 mg, 0.060 mmol, 77.1% yield) as yellow solid. LC-MS: m/z = 506.1, [M+H] ⁺ , ESI pos.

Step 5: 5-[ 3-(l -hydroxyethyl)-6-[5-[ ( 6-methylpyridazin-3-yl)amino ]benzimidazol-l-yl ]-2- pyridyl ]-4-( trifluor ome thy l)pyridin-2-ol Prepared in analogy to example 53, step 4 to yield 5-[3-(l-hydroxyethyl)-6-[5-[(6- methylpyridazin-3-yl)amino]benzimidazol-l-yl]-2-pyridyl]-4-( trifluoromethyl)pyridin-2-ol (10.1 mg, 0.020 mmol, 32.7% yield) as grey solid. LC-MS: m/z = 508.1, [M+H] ⁺ , ESI pos.

Example 165

3- [3-(l-Hydroxyethyl)-6- [5- [(6-methylpyridazin-3-yl)amino] benzimidazol-l-yl]-2-pyridyl]- 6,7-dihydro-5H-pyrazolo[l,5-a]pyrazin-4-one

Step 1: 6, 7-dihydro-5H-pyrazolo[l,5-a]pyrazin-4-one To a solution of tert-butyl N-(2-bromoethyl)carbamate (10.66 g, 47.58 mmol, 1.2 equiv.) in DMF (100 mL) was added tert-butyl N-(2-bromoethyl)carbamate (10.66 g, 47.58 mmol, 1.2 equiv.) and CS2CO3 (25.84 g, 79.3 mmol, 2 equiv.). The mixture was stirred at 30 °C for 12 hours. The mixture was filtered and the filter cake rinsed with EtOAc. The filtrate was concentrated under reduced pressure to remove EtOAc, diluted with water, and extracted with EtOAc. The combined extracts were washed with brine and concentrated under reduced pressure. The residue was purified by flash column chromatography (0 - 25% EtOAc in PE) and concentrated under reduced pressure to give colorless oil. This oil was dissolved in 1,4-dioxane (20 mL) 4M HC1 in 1,4-dioxane (20.0 mL, 80 mmol, 2.02 equiv.) was added at 0 °C. The mixture was stirred at 20 °C for 2 hours. The volatiles were removed, and the residue was dissolved in 1,4-dioxane (50 mL) and sodium carbonate (16.81 g, 158.59 mmol, 4 equiv.) was added as a solid. The mixture was stirred at 30 °C for 12 hours. The reaction mixture was filtered and the filter cake rinsed with EtOAc. The filtrate was concentrated under reduced pressure to remove the volatiles. The residue was purified by flash column chromatography (0 - 100% EtOAc in PE) to yield 6,7-dihydro-5H-pyrazolo[l,5-a]pyrazin-4-one (1.5 g, 10.94 mmol, 27.6% yield) as an orange powder. LC-MS: m/z = 138.2, [M+H] ⁺ , ESI pos.

Step 2: 3-bromo-6, 7-dihydro-5H-pyrazolo [ 1 ,5-a] pyrazin-4-one

To a solution of 6,7-dihydro-5H-pyrazolo[l,5-a]pyrazin-4-one (1.5 g, 10.94 mmol, 1.0 equiv.) in DMF (15 mL) was added 1 -bromopyrrolidine-2, 5-dione (2.14 g, 12.03 mmol, 1.1.0 equiv.). The mixture was stirred at 30 °C for 12 hours. The reaction mixture was poured into aq. sat. NH4CI and stirred for 10 min. Then mixture was filtered and rinsed with water (10 mL*2) and sat. Na2S2C>3 (10 mL). The filter cake was concentrated under reduced pressure yield 3-bromo-6,7- dihydro-5H-pyrazolo[l,5-a]pyrazin-4-one (2.2 g, 10.18 mmol, 93.1% yield) as an off-white solid. LC-MS: m/z = 216.0, [M+H] ⁺ , ESI pos.

Step 3: (4-oxo-6, 7-dihydro-5H-pyrazolo[l,5-a]pyrazin-3-yl)boronic acid Prepared in analogy to example 143, step 2 using 3-bromo-6,7-dihydro-5H-pyrazolo[l,5- a]pyrazin-4-one (500.0 mg, 2.31 mmol, 1.0 equiv.) to yield (4-oxo-6,7-dihydro-5H-pyrazolo[l,5- a]pyrazin-3-yl)boronic acid (800 mg, 4.42 mmol, 48.61% yield) as a yellow solid. LC-MS: m/z = 182.1, [M+H] ⁺ , ESI pos.

Step 4: 3-[3-acetyl-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol -l-yl]-2-pyridyl]-6, 7- dihydro-5H-pyrazolo[ 1, 5 -a ]pyrazin-4-one

Prepared in analogy to example 143, step 2 (4-oxo-6,7-dihydro-5H-pyrazolo[l,5-a]pyrazin-3- yl)boronic acid (600.0 mg, 1.23 mmol, 7.75 equiv.) and l-[2-chloro-6-[5-[(6-methylpyridazin-3- yl)amino]benzimidazol-l-yl]-3-pyridyl]ethanone ((60.0 mg, 0.160 mmol, 1.0 equiv., prepared in example 76, step 2) to yield 3-[3-acetyl-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol -l- yl]-2-pyridyl]-6,7-dihydro-5H-pyrazolo[l,5-a]pyrazin-4-one (35 mg, 0.070 mmol, 45.6% yield) as a brown solid. LC-MS: m/z = 480.2, [M+H] ⁺ , ESI pos.

Step 5: 3-[3-(l -hydroxyethyl)-6-[5-[ ( 6-methylpyridazin-3-yl)amino ]benzimidazol-l-yl -2- pyridyl -6, 7-dihydro-5H-pyrazolo[ 1, 5 -a ]pyrazin-4-one

Prepared in analogy to example 53, step 4 to give the 3-[3-(l-hydroxyethyl)-6-[5-[(6- methylpyridazin-3-yl)amino]benzimidazol-l-yl]-2-pyridyl]-6,7 -dihydro-5H-pyrazolo[l,5- a]pyrazin-4-one (6.8 mg, 0.010 mmol, 22.6% yield) as a white solid. LC-MS: m/z = 482.2, [M+H] ⁺ , ESI pos. Example 166 l-[6-[6-Fluoro-5-[[(3S,4R)-4-fluoropyrrolidin-3-yl]amino]ben zimidazol-l-yl]-3-(l- hydroxyethyl)-2-pyridyl]-5-methyl-pyrazole-3-carbonitrile; formic acid

Step 1: tert-butyl (3R,4S)-3-fluoro-4-(2-fluoro-4,5-dinitro-anilino)pyrrolidine -l-carboxylate

To a solution of l,2-difluoro-4,5-dinitro-benzene (450.0 mg, 2.2 mmol, 1.0 equiv.) in DMF (10 mL) was added tert-butyl (3 S,4R)-3-amino-4-fluoropyrrolidine-l -carboxylate (450.0 mg, 2.2 mmol, 1.0 equiv.) and N,N-Diisopropylethylamine (1.09 mL, 6.61 mmol, 3.0 equiv.). The reaction mixture was stirred at 30 °C for 12 hours. The reaction mixture was diluted with water, and extracted with EtOAc. The organic layers were washed with brine and concentrated under vacuum to yield tert-butyl (3R,4S)-3-fluoro-4-(2-fluoro-4,5-dinitro-anilino)pyrrolidine -l- carboxylate (800 mg, 2.06 mmol, 93.4% yield) as yellow solid. LC-MS: m/z = 289.1 [M- Boc+H] ⁺ , ESI pos.

Step 2: 6-fluoro-N-[ ( 3S, 4R)-4-fluoropyrrolidin-3-yl / -lH-benzimidazol-5-amine

A solution of tert-butyl (3R,4S)-3-fluoro-4-(2-fluoro-4,5-dinitro-anilino)pyrrolidine -l- carboxylate (550.0 mg, 1.42 mmol, 1.0 equiv.) in formic acid (65.19 mg, 1.42 mmol, 1.0 equiv.) was added nickel (83.13 mg, 1.42 mmol, 1.0 equiv.). The mixture was stirred at 30 °C for 12 h under EE atmosphere (50 psi). The mixture was filtered through a pad of celite and the filtrate was concentrated in vacuo to yield crude 6-fluoro-N-[(3S,4R)-4-fluoropyrrolidin-3-yl]-lH- benzimidazol-5-amine (500 mg, 2.1 mmol, 74.1% yield) as dark brown gum. LC-MS: m/z = 239.1 [M+H] ⁺ , ESI pos.

Step 3: tert-butyl (3R,4S)-3-fluoro-4-[(6-fluoro-lH-benzimidazol-5-yl)amino]pyr rolidine-l- carboxylate

To a solution of 6-fluoro-N-[(3S,4R)-4-fluoropyrrolidin-3-yl]-lH-benzimidazol -5-amine (600.0 mg, 1.26 mmol, 1.0 equiv.) in DCM (10 mL) and was added TEA (382.27 mg, 3.78 mmol, 3 equiv.) and tert-butyl (2-methylpropan-2-yl)oxycarbonyl carbonate (412.24 mg, 1.89 mmol, 1.5 equiv.). The mixture was stirred at 25 °C for 12 hours. The mixture was poured into water and extracted with EtOAc. The combined organic layers were washed with brine, dried over ISfeSCU, filtered and the filtrate was concentrated in vacuo. The residue was dissolved in MeOH, and to the solution was added sat. aq. K2CO3. The mixture was stirred at 25 °C for 12 hours. The mixture was extracted with EtOAc and the combined organic layers were dried over Na2SO4, filtered and the filtrate was concentrated in vacuo. The residue was purified by prep-HPLC (Waters Xbridge C18 150 mm x 50 mm x 10 pm, gradient 3 - 33% CH3CN in H2O (with 10 mM NH4CO3) over 11 min, then 100% CH3CN (2 min), flow rate 60 mL/min)), and the eluent was lyophilized to yield tert-butyl (3R,4S)-3-fluoro-4-[(6-fluoro-lH-benzimidazol-5- yl)amino]pyrrolidine-l -carboxylate (180 mg, 0.530 mmol, 42.3% yield) as off-white solid. LC- MS: m/z = 339.2 [M+H] ⁺ , ESI pos.

Step 4: tert-butyl (3S,4R)-3-[[l-[5-acetyl-6-(3-cyano-5-methyl-pyrazol-l-yl)-2- pyridyl]-6-fluoro- benzimidazol-5-yl] amino] -4-fluoro-pyrrolidine-l-carboxylate

Prepared in analogy to example 64, step 2 using tert-butyl rac-(3R,4S)-3-fluoro-4-[(6-fluoro-lH- benzimidazol-5-yl)amino]pyrrolidine-l -carboxylate (170.0 mg, 0.500 mmol, 1.0 equiv.) and 1- (3-acetyl-6-chloro-2-pyridyl)-5-methyl-pyrazole-3-carbonitri le (196.46 mg, 0.750 mmol, 1.5 equiv., prepared in Exaple 64, step 1) to yield tert-butyl (3S,4R)-3-[[3-[5-acetyl-6-(3-cyano-5- methyl-pyrazol-l-yl)-2-pyridyl]-6-fluoro-benzimidazol-5-yl]a mino]-4-fluoro-pyrrolidine-l- carboxylate (40 mg, 0.070 mmol, 14.2% yield) and tert-butyl (3S,4R)-3-[[l-[5-acetyl-6-(3- cyano-5-methyl-pyrazol-l-yl)-2-pyridyl]-6-fluoro-benzimidazo l-5-yl]amino]-4-fluoro- pyrrolidine-1 -carboxylate (50 mg, 0.090 mmol, 17.7% yield) as light yellow gums. The regioisomers were separated by preparative NPLC (Welch Ultimate XB-SiOH 250 x 50 x 10 pm, 10 - 50% EtOH (0.1% ammonium hydroxide) in hexane over 15 min, then 100% EtOH (0.1% ammonium hydroxide) (5 min), flow rate 100 mL/min). LC-MS: m/z = 563.2 [M+H] ⁺ , ESI pos. Regioisomer 1 : 'H NMR (400 MHz, CDC1 ₃ ) 8 = 8.52 (s, 1H), 8.28 (d, J= 8.4 Hz, 1H), 7.78 (d, J= 11.1 Hz, 1H), 7.68 (d, J= 8.4 Hz, 1H), 7.18 (d, J= 7.8 Hz, 1H), 6.73 (s, 1H), 5.36 - 5.13 (m, 1H), 4.41 (br d, J= 7.8 Hz, 1H), 4.27 - 4.02 (m, 2H), 3.73 (q, J= 6.9 Hz, 1H), 3.21 (q, J = 9.7 Hz, 1H), 2.61 (s, 3H), 2.20 (s, 3H), 1.49 (s, 9H). Regioisomer 2 : 'H NMR (400 MHz, CDCI3) 6 = 8.45 - 8.37 (m, 1H), 8.32 (d, J= 8.3 Hz, 1H), 7.70 (br d, J= 8.3 Hz, 1H), 7.51 (br d, J= 11.1 Hz, 1H), 7.40 (d, J = 7.5 Hz, 1H), 6.76 - 6.67 (m, 1H), 5.28 - 5.04 (m, 1H), 4.64 - 4.40 (m, 1H), 4.04 - 3.53 (m, 4H), 3.27 - 3.11 (m, 1H), 2.58 (s, 3H), 2.26 - 2.17 (s, 3H), 1.54 - 1.46 (s, 9H). Step 5: l-[ 3-acetyl-6-[ 6-fluoro-5-[ [ ( 3S, 4R)-4-jluoropyrrolidin-3-yl ] amino ]benzimidazol-l-yl ]- 2-pyridyl]-5-methyl-pyrazole-3-carbonitrile

A solution of tert-butyl (3S,4R)-3-[[l-[5-acetyl-6-(3-cyano-5-methyl-pyrazol-l-yl)-2- pyridyl]-6- fluoro-benzimidazol-5-yl]amino]-4-fluoro-pyrrolidine-l-carbo xylate (50.0 mg, 0.090 mmol, 1.0 equiv.) and trifluoroacetic acid (0.63 mL, 8.11 mmol, 91.3 equiv.) in DCM (2.5 mL) was stirred at 25 °C for 1 hour. The mixture was concentrated in vacuo to yield 60 mg of crude l-[3-acetyl- 6-[6-fluoro-5-[[(3S,4R)-4-fluoropyrrolidin-3-yl]amino]benzim idazol-l-yl]-2-pyridyl]-5-methyl- pyrazole-3 -carbonitrile. The crude product was used in next step without further purification. LC-MS: m/z = 463.1 [M+H] ⁺ , ESI pos.

Step 6: l-[ 6-[ 6-fluoro-5-[ [ ( 3S, 4R)-4-fluoropyrrolidin-3-yl amino ]benzimidazol-l-yl -3-( 1 - hydroxyethyl)-2-pyridyl ]-5-methyl-pyrazole-3-carbonitrile; formic acid

To a solution of l-[3-acetyl-6-[6-fluoro-5-[[(3S,4R)-4-fluoropyrrolidin-3- yl]amino]benzimidazol-l-yl]-2-pyridyl]-5-methyl-pyrazole-3-c arbonitrile;2, 2, 2-tri fluoroacetic acid (used as crude from the previous step) in methanol (3 mL) was added NaBEL (11.81 mg, 0.310 mmol, 3.0 equiv.) at 0 °C and stirred for 30 min. The mixture was quenched by sat. aq. NH4CI and extracted with EtOAc. The combined organic layers were dried over ISfeSCU and was concentrated in vacuo. The residue was purified by preparative HPLC (Waters Xbridge 150*25mm*5um, H ₂ O (lOmM NH4HCO3) - CH3CN, 23 - 53% B, gradient time 8 min, 100% B hold time 2 min, flow rate 25 mL/min), the eluent was lyophilized to yield l-[6-[6-fluoro-5- [[(3S,4R)-4-fluoropyrrolidin-3-yl]amino]benzimidazol-l-yl]-3 -(l-hydroxyethyl)-2-pyridyl]-5- methyl-pyrazole-3 -carbonitrile; formic acid (13.6 mg, 0.030 mmol, 26.73% yield) as white solid. LC-MS: m/z = 465.3 [M+H] ⁺ , ESI pos. Example 167 l-[2-[2-(Difluoromethoxy)-5-methyl-4-pyridyl]-6-[5-[(6-methy lpyridazin-3- yl)amino]benzimidazol-l-yl]-3-pyridyl]ethanol

Step 1: 4-bromo-2-(difluoromethoxy)-5-methyl-pyridine

A mixture of 4-bromo-5-methyl-pyridin-2-ol (290.0 mg, 1.54 mmol, 1.0 equiv.), CS2CO3 (1.01 g, 3.08 mmol, 2.0 equiv.) and sodium chlorodifluoroacetate (705.46 mg, 4.63 mmol, 3.0 equiv.) in DMF (5 mL) was stirred at 100 °C for 12 hours. The reaction mixture was filtered, the filtrate was dissolved in brine, extracted with ethyl acetate, and the combined extracts were concentrated under reduced pressure. The residue was purified by flash column chromatography (9% EtOAc in PE) to yield 4-bromo-2-(difluoromethoxy)-5-methyl-pyridine (200 mg, 0.840 mmol, 54.48% yield) as a colorless oil. LC-MS: m/z = 238.0, [M+H] ⁺ , ESI pos.

Step 2: 2-(difluoromethoxy)-5-methyl-4-(4,4,5,5-tetramethyl-l,3,2-di oxaborolan-2-yl)pyridine

Prepared in analogy to example 143, step 2 using 4-bromo-2-(difluoromethoxy)-5-methyl- pyridine (150.0 mg, 0.630 mmol, 1.0 equiv) to yield 2-(difluoromethoxy)-5-methyl-4-(4, 4,5,5- tetramethyl-l,3,2-dioxaborolan-2-yl)pyridine (250 mg, 0.880 mmol, 139.2% yield) as a yellow oil. LC-MS: m/z = 286.2, [M+H] ⁺ , ESI pos. Step 3: l-[2-[2-(dijluoromethoxy)-5-methyl-4-pyridyl]-6-[5-[(6-methy lpyridazin-3- yl amino ]benzimidazol-l-yl ]-3-pyridyl ethanone

Prepared in analogy to example 143, step 2 using l-[2-chloro-6-[5-[(6-methylpyridazin-3- yl)amino]benzimidazol-l-yl]-3-pyridyl]ethanone (50.0 mg, 0.130 mmol, 1.0 equiv., prepared in example 76, step 2), and 2-(difluoromethoxy)-5-methyl-4-(4,4,5,5-tetramethyl-l,3,2- dioxaborolan-2-yl)pyridine (718.5 mg, 2.5 mmol, 20 equiv.) to afford l-[2-[2- (difluoromethoxy)-5-methyl-4-pyridyl]-6-[5-[(6-methylpyridaz in-3-yl)amino]benzimidazol-l- yl]-3-pyridyl]ethanone (30 mg, 0.060 mmol, 45.3% yield) as a yellow solid. LC-MS: m/z = 502.3, [M+H] ⁺ , ESI pos.

Step 4: l-[ 2-[ 2-(difluoromethoxy)-5-methyl-4-pyridyl ]-6-[5-[ ( 6-methylpyridazin-3- yl)amino ]benzimidazol-l-yl ]-3-pyridyl ethanol

Prepared in analogy to example 53, step 4 using 5.0 equivalents of NaBEL (11.37 mg, 0.300 mmol) to yield l-[2-[2-(difluoromethoxy)-5-methyl-4-pyridyl]-6-[5-[(6-methy lpyridazin-3- yl)amino]benzimidazol-l-yl]-3-pyridyl]ethanol (19.4 mg, 0.040 mmol, 64.4% yield) as a yellow solid. LC-MS: m/z = 502.4, [M+H] ⁺ , ESI pos.

Example 168

1- [2-(2-Fluoro-5-methyl-4-pyridyl)-6- [5- [(6-methylpyridazin-3-yl)amino] benzimidazol- 1- yl] -3-pyridyl] ethanol

Step 1 : 2-fluoro-5-methyl-4-( 4, 4, 5, 5 -tetr ame thy l-l , 3, 2-dioxaborolan-2-yl)pyridine

Prepared in analogy to example 143, step 2 using 4-bromo-2-fluoro-5-methyl-pyridine (950.0 mg, 5 mmol, 1.0 equiv.) to afford 2-fluoro-5-methyl-4-(4,4,5,5-tetramethyl-l,3,2-dioxaborolan- 2-yl)pyridine (1000 mg, 4.22 mmol, 84.4% yield) as light yellow solid. LC-MS: m/z = 238.1 [M+H] ⁺ , ESI pos. 'H NMR (400MHz, CDC1 ₃ ) 8 = 8.00 (s, 1H), 7.22 (s, 1H), 2.44 (s, 3H), 1.35 (s, 13H).

Step 2: l-[2-(2-fluoro-5-methyl-4-pyridyl)-6-[5-[(6-methylpyridazin- 3-yl)amino]benzimidazol-l- yl] -3-pyridyl ethanone

Prepared in analogy to example 143, step 2 using l-[2-chloro-6-[5-[(6-methylpyridazin-3- yl)amino]benzimidazol-l-yl]-3-pyridyl]ethanone (50.0 mg, 0.130 mmol, 1.0 equiv., prepared in example 76, step 2) and 2-fluoro-5-methyl-4-(4,4,5,5-tetramethyl-l,3,2-dioxaborolan- 2- yl)pyridine (125.17 mg, 0.530 mmol, 4.0 equiv.) to yield l-[2-(2-fluoro-5-methyl-4-pyridyl)-6- [5-[(6-methylpyridazin-3-yl)amino]benzimidazol-l-yl]-3-pyrid yl]ethanone (30 mg, 0.070 mmol,

50.1% yield) as grey solid. LC-MS: m/z = 454.1 [M+H] , ESI pos. Step 3: l-[2-(2-fluoro-5-methyl-4-pyridyl)-6-[5-[(6-methylpyridazin- 3-yl)amino]benzimidazol-l- yl] -3-pyridyl ethanol

Prepared in analogy to example 53, step 4 using 5.0 equivalents of NaBEL (11.26 mg, 0.300 mmol, 5 equiv.) LC-MS: m/z = 456.2 [M+H] ⁺ , ESI pos.

Example 169

1- [3-(l-Hydroxyethyl)-6- [6- [(6-methylpyridazin-3-yl)amino] benzimidazol-l-yl]-2-pyridyl]- 4-methyl-pyrazole-3-carbonitrile; formic acid Step 1: l-(3-acetyl-6-chloro-2-pyridyl)-4-bromo-pyrazole-3-carbonitr ile

Prepared in analogy to example 62, step 1 using 4-bromopyrazole-3 -carbonitrile (1.0 g, 5.81 mmol, 1.0 equiv.) to afford 1 -(3 -acetyl-6-chloro-2-pyridyl)-4-bromo-pyrazole-3 -carbonitrile (1.5 g, 4.61 mmol, 79.2% yield) as off-white solid. LC-MS: m/z = 326.8 [M+H] ⁺ , ESI pos. Step 2: l-[ 3-acetyl-6-[ 6-[ ( 6-methylpyridazin-3-yl)amino ]benzimidazol-l-yl ]-2-pyridyl ]-4- bromo-pyrazole-3-carbonitrile and l-[ 3-acetyl-6-[5-[ ( 6-methylpyridazin-3- yl)amino ]benzimidazol-l-yl / -2 -pyridyl ]-4-bromo-pyrazole-3-carbonitrile

Prepared in analogy to example 76, step 1 using l-(3-acetyl-6-chloro-2-pyridyl)-4-bromo- pyrazole-3 -carbonitrile (1.0 g, 3.07 mmol, 1.0 equiv.) and N-(6-methylpyridazin-3-yl)-lH- benzimidazol-5-amine (0.83 g, 3.69 mmol, 1.2 equiv., prepared in example 64, step 1) to provide l-[3-acetyl-6-[6-[(6-methylpyridazin-3-yl)amino]benzimidazol -l-yl]-2-pyridyl]-4-bromo- pyrazole-3 -carbonitrile (350 mg, 0.680 mmol, 22.2% yield) and l-[3-acetyl-6-[5-[(6- methylpyridazin-3-yl)amino]benzimidazol-l-yl]-2-pyridyl]-4-b romo-pyrazole-3-carbonitrile (160 mg, 0.310 mmol, 10.1% yield) as an light brown solid. Regioisomer 1 : LC-MS: m/z = 514.0 [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, DMSO-t/ ₆ ) 8 = 9.32 (s, 1H), 9.29 (s, 1H), 9.17 (s, 1H), 8.44 (d, J= 1.7 Hz, 1H), 8.40 (d, J= 8.4 Hz, 1H), 8.21 (dd, J= 8.7, 10.7 Hz, 2H), 7.61 (dd, J= 1.8, 8.8 Hz, 1H), 7.35 (d, J= 9.2 Hz, 1H), 7.10 (d, J= 9.0 Hz, 1H), 2.49 (s, 3H), 2.41 (s, 3H). Regioisomer 2: LC-MS: m/z = 514.0 [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, DMSO-t/ ₆ ) 6 = 9.64 (d, J= 1.7 Hz, 1H), 9.45 (s, 1H), 9.39 (s, 1H), 8.99 (s, 1H), 8.40 (d, J= 8.4 Hz, 1H), 8.20 - 8.13 (m, 1H), 7.68 (d, J= 8.7 Hz, 1H), 7.37 (d, J = 9.0 Hz, 1H), 7.25 (dd, J= 1.9, 8.7 Hz, 1H), 7.15 (d, J= 9.0 Hz, 1H), 2.51 (br d, J= 1.5 Hz, 3H), 2.43 (s, 2H).

Step 3: l-[ 3-acetyl-6-[ 6-[ ( 6-methylpyridazin-3-yl)amino ]benzimidazol-l-yl ]-2-pyridyl ]-4- methyl-pyrazole-3-carbonitrile

Prepared in analogy to example 169/170, step 3 using l-[3-acetyl-6-[6-[(6-methylpyridazin-3- yl)amino]benzimidazol-l-yl]-2-pyridyl]-4-bromo-pyrazole-3-ca rbonitrile (50.0 mg, 0.100 mmol, 1.0 equiv.) to afford the title compound as an off-white solid (25.1 mg, 0.056 mmol, 56.2% yield). LC-MS: m/z = 450.1, [M+H] ⁺ , ESI pos.

Step 4: l-[3-(l -hydroxyethyl)-6-[ 6-[ ( 6-methylpyridazin-3-yl)amino ]benzimidazol-l-yl ]-2- pyridyl ]-4-methyl-pyrazole-3-carbonitrile; formic acid

Prepared in analogy to example 53, step 4 using l-[3-acetyl-6-[6-[(6-methylpyridazin-3- yl)amino]benzimidazol-l-yl]-2-pyridyl]-4-methyl-pyrazole-3-c arbonitrile (20.0 mg, 0.040 mmol, 1.0 equiv.) in MeOH/DCM (5: 1) to provide l-[3-(l-hydroxyethyl)-6-[6-[(6-methylpyridazin-3- yl)amino]benzimidazol-l-yl]-2-pyridyl]-4-methyl-pyrazole-3-c arbonitrile; formic acid (3.8 mg, 0.010 mmol, 14.9% yield) as yellow solid by lyophilization. LC-MS: m/z = 452.2, [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, CD ₃ OD) 5 = 9.31 (d, J = 1.7 Hz, 1H), 8.86 - 8.81 (m, 1H), 8.71 (s, 1H), 8.57 (d, J= 8.4 Hz, 1H), 8.44 (br s, 2H), 8.03 - 7.98 (m, 1H), 7.69 (d, J= 8.8 Hz, 1H), 7.40 (d, J= 9.2 Hz, 1H), 7.30 (dd, J= 1.8, 8.6 Hz, 1H), 7.20 - 7.15 (m, 1H), 5.61 (q, J= 6.3 Hz, 1H), 2.58 (s, 3H), 2.21 (s, 3H), 1.54 (d, J= 6.4 Hz, 3H).

Example 170

1- [3-(l-Hydroxyethyl)-6- [5- [(6-methylpyridazin-3-yl)amino] benzimidazol-l-yl]-2-pyridyl]- 4-methyl-pyrazole-3-carbonitrile; formic acid Step 1 : l-[ 3-acetyl-6-[5-[ ( 6-methylpyridazin-3-yl)amino ]benzimidazol-l-yl / -2 -pyridyl ]-4- methyl-pyrazole-3-carbonitrile

To a solution of l-[3-acetyl-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol -l-yl]-2-pyridyl]- 4-bromo-pyrazole-3 -carbonitrile (200.0 mg, 0.390 mmol, 1.0 equiv., provided in example 169, step 2) and trimethylboroxine (195.25 mg, 0.780 mmol, 2.0 equiv.) in DMF (15 mL) were added K3PO4 (0.13 mL, 1.56 mmol, 4.0 equiv.) and PdCh(dppf) CH2C12 (31.73 mg, 0.040 mmol, 0.10 equiv.). The mixture was purged with nitrogen for several min, and then the reaction was stirred at 100 °C for 12 h under nitrogen atmosphere. The mixture was poured into water and extracted with EtOAc. The organic layers were separated, dried over ISfeSCU, filtered and concentracted under reduce pressure. The crude was purified by preparative TLC (10% MeOH in DCM) to provide l-[3-acetyl-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol -l-yl]-2-pyridyl]-4- methyl-pyrazole-3 -carbonitrile (40 mg, 0.090 mmol, 22.9% yield) as off white solid. LC-MS: m/z = 450.2, [M+H] ⁺ , ESI pos.

Step 2: l-[ 3-( 1 -hydroxyethyl)-6-[5-[ ( 6-methylpyridazin-3-yl)amino ]benzimidazol-l-yl ]-2- pyridyl ]-4-methyl-pyrazole-3-carbonitrile; formic acid

Prepared in analogy to example 53, step 4 using l-[3-acetyl-6-[5-[(6-methylpyridazin-3- yl)amino]benzimidazol-l-yl]-2-pyridyl]-4-methyl-pyrazole-3-c arbonitrile (40.0 mg, 0.090 mmol, 1.0 equiv.) in MeOH/DCM (5: 1) to provide l-[3-(l-hydroxyethyl)-6-[5-[(6-methylpyridazin-3- yl)amino]benzimidazol-l-yl]-2-pyridyl]-4-methyl-pyrazole-3-c arbonitrile; formic acid (10.3 mg, 0.020 mmol, 23.3% yield) as yellow solid. LC-MS: m/z = 452.2, [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, CD3OD) 5 = 8.93 (s, 1H), 8.53 (d, J= 8.4 Hz, 1H), 8.49 (s, 1H), 8.41 (br s, 1H), 8.24 (d, J= 1.8 Hz, 1H), 8.17 (d, J= 8.8 Hz, 1H), 8.02 (d, J= 8.3 Hz, 1H), 7.67 (dd, J= 1.9, 9.0 Hz, 1H), 7.38 (d, J= 9.0 Hz, 1H), 7.15 (d, J= 9.2 Hz, 1H), 5.53 (q, J= 6.0 Hz, 1H), 2.56 (s, 3H), 2.36 (s, 3H), 1.52 (d, J= 6.4 Hz, 3H).

Example 171

1- [6- [5- [(6-Methylpyridazin-3-yl)amino] benzimidazol-l-yl]-2-[5-methyl-3- (trifluoromethyl)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-l-yl ]-3-pyridyl]ethanol; formic acid

Step 1: l-[ 6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-l-yl]-2-[5- methyl-3- ( trifluoromethyl) -6, 7-dihydro-4H-pyrazolo[ 4, 3-c ]pyridin-l-yl ]-3-pyridyl ethanone

A solution of l-[6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-l-yl]-2- [3-(trifluoromethyl)- 4,5,6,7-tetrahydropyrazolo[4,3-c]pyridin-l-yl]-3-pyridyl]eth anone;hydrochloride (300.0 mg, 0.530 mmol, 1.0 equiv., prepared in example 97, step 3) and formaldehyde (50.0 mg, 1.67 mmol, 3.2 equiv.) in MeOH (10 mL) was stirred at 30 °C for 30 min. Then NaBHsCN (100.0 mg, 1.59 mmol, 3.0 equiv.) was added to the mixture which was further stirred at 30 °C for 1.5 hours. The reaction mixture was diluted with water and extracted with EtOAc . The combined organic layers were dried over Na2SO4, filtered and concentrated under reduced pressure to yield crude l-[6-[5- [(6-methylpyridazin-3-yl)amino]benzimidazol-l-yl]-2-[5-methy l-3-(trifluoromethyl)-6,7- dihydro-4H-pyrazolo[4,3-c]pyridin-l-yl]-3-pyridyl]ethanone (183 mg, 0.334 mmol, 63.1% yield) as yellow solid. The crude product was used without further purification. LC-MS: m/z = 548.3 [M+H] ⁺ , ESI pos.

Step 2: l-[6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-l-yl]-2- [5-methyl-3- (trifluoromethyl)-6, 7-dihydro-4H-pyrazolo[ 4, 3-c ]pyridin-l-yl ]-3-pyridyl ethanol; formic acid

Prepared in analogy to example 53, step 4 in DCM/MeOH (9:1) using l-[6-[5-[(6- methylpyridazin-3-yl)amino]benzimidazol-l-yl]-2-[5-methyl-3- (trifluoromethyl)-6,7-dihydro- 4H-pyrazolo[4,3-c]pyridin-l-yl]-3-pyridyl]ethanone (183 mg, 0.334 mmol, 1.0 eq.) to yield l-[6- [5-[(6-methylpyridazin-3-yl)amino]benzimidazol-l-yl]-2-[5-me thyl-3-(trifluoromethyl)-6,7- dihydro-4H-pyrazolo[4,3-c]pyridin-l-yl]-3-pyridyl]ethanol; formic acid (58 mg, 0.106 mmol, 31.8% yield) as light yellow solid. LC-MS: m/z = 550.2 [M+H] ⁺ , ESI pos.

Example 172 l-[[[3-(l-hydroxyethyl)-6-[6-[(6-methylpyridazin-3-yl)amino] benzimidazol-l-yl]-2-pyridyl]- methyl-amino] methyl] cyclopropanecarbonitrile

Step 1: tert-butyl N-[(l-cyanocyclopropyl)methyl] carbamate

To a solution of l-(aminomethyl)cyclopropanecarbonitrile;hydrochloride (450.0 mg, 3.39 mmol, 1.0 equiv.) in DCM (15 mL) was added tert-butyl (2-methylpropan-2-yl)oxycarbonyl carbonate (962.9 mg, 4.41 mmol, 1.3 equiv.) and TEA (1.03 g, 10.18 mmol, 3.0 equiv.). The mixture was stirred at 30 °C for 12 hours. The mixture was diluted with DCM and purified by flash column chromatography (10 - 90% MeOH in DCM) to yield tert-butyl N-[(l- cyanocyclopropyl)methyl]carbamate (350 mg, 1.78 mmol, 52.6% yield) as an off-white solid. ^J H NMR (400 MHz, CDCI3) 5 = 3.25 (d, J= 6.4 Hz, 2H), 1.46 (s, 9H), 1.29 - 1.22 (m, 2H), 1.06 (s, 2H).

Step 2: tert-butyl N-[(l-cyanocyclopropyl)methyl]-N-methyl-carbamate

To a solution of tert-butyl N-[(l-cyanocyclopropyl)methyl]carbamate (680.0 mg, 3.46 mmol, 1.0 equiv.) in THF (15 mL) und inert atmosphere was added NaH (207.9 mg, 5.2 mmol, 1.5 equiv.) at 0 °C. The mixture was stirred at 0 °C for 30 min. Then Mel (737.7 mg, 5.2 mmol, 1.5 equiv.) was added. The mixture was warmed to 25 °C and stirred for 12 hours. The mixture was quenched by sat. aq. NH4CI and extracted with EtOAc. The combined organic layers were dried over Na2SO4 and the volatiles evaporated to yield crude tert-butyl N-[(l- cyanocyclopropyl)methyl]-N-methyl-carbamate as yellow oil which was used without further purification in the next step.

Step 3: l-(methylaminomethyl)cyclopropanecarbonitrile;2,2,2-trifluor oacetic acid

A solution of tert-butyl N-[(l-cyanocyclopropyl)methyl]-N-methyl-carbamate (used as crude from the previous step) and TFA (5.0 mL, 64.9 mmol, 20 equiv.) in DCM (5 mL) was stirred at 30 °C for 12 hours. The mixture was concentrated in vacuo to give the crude product 1- (methylaminomethyl)cyclopropanecarbonitrile;2,2,2-trifluoroa cetic as light yellow gum which was used in the next step without further purification. LC-MS: m/z = 111.1 [M+H] ⁺ , ESI pos.

Step 4: l-[[ ( 3-acetyl-6-chloro-2-pyridyl)-methyl-amino ] methyl cyclopropanecarbonitrile To a solution of l-(6-chloro-2-fluoro-3-pyridyl)ethanone (CAS# 1260663-13-5, 696.8 mg, 4.01 mmol, 1.2 equiv.), l-(methylaminomethyl)cyclopropanecarbonitrile;2,2,2-trifluor oacetic acid (used as crude from the previous step) in DMSO (8 mL) was added DIPEA (1.66 mL, 10.04 mmol, 3.0 equiv.) and was stirred at 30 °C for 12 hours. The mixture was diluted with water and extracted with EtOAc. The combined organic layers were washed with brine, dried over Na2SO4, and the volatiles evaporated. The residue was purified by flash column chromatography (10 - 33% EtOAc in PE) to yield l-[[(3-acetyl-6-chloro-2-pyridyl)-methyl- amino]methyl]cyclopropanecarbonitrile (650 mg, 2.46 mmol, 70.7% yield) as a colorless gum. LC-MS: m/z = 254.0 [M+H] ⁺ , ESI pos.

Step 5: !-[[[ 3-acetyl-6-[ 6-[ ( 6-methylpyridazin-3-yl)amino ]benzimidazol-l-yl / -2 -pyridyl ]- methyl-amino ] methyl cyclopropanecarbonitrile and !-[[[ 3-acetyl-6-[5-[ ( 6-methylpyridazin-3- yl)amino ]benzimidazol-l-yl / -2 -pyridyl / -methyl-amino ] methyl cyclopropanecarbonitrile

Prepared in analogy to example 64, step 2 using l-[[(3-acetyl-6-chloro-2-pyridyl)-methyl- amino]methyl]cyclopropanecarbonitrile (550.0 mg, 2.09 mmol, 1.0 equiv.) and N-(6- methylpyridazin-3-yl)-lH-benzimidazol-5-amine (704.65 mg, 3.13 mmol, 1.5 equiv., prepared in example 64, intermediate 1) to yield l-[[[3-acetyl-6-[6-[(6-methylpyridazin-3- yl)amino]benzimidazol-l-yl]-2-pyridyl]-methyl-amino]methyl]c yclopropanecarbonitrile (110 mg, 0.240 mmol, 11.7% yield) as yellow solid and l-[[[3-acetyl-6-[5-[(6-methylpyridazin-3- yl)amino]benzimidazol-l-yl]-2-pyridyl]-methyl-amino]methyl]c yclopropanecarbonitrile (110 mg, 0.240 mmol, 11.7% yield) as brown solid. Regioisomer 1 : LC-MS: m/z = 453.2 [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, DMSO-t/ ₆ ) 8 = 9.33 (br s, 2H), 8.86 (s, 1H), 8.21 (d, J= 8.2 Hz, 1H), 7.67 (d, J= 8.7 Hz, 1H), 7.36 (d, J = 9.0 Hz, 1H), 7.29 (d, J= 8.2 Hz, 1H), 7.25 (dd, J = 1.7, 8.9 Hz, 1H), 7.13 (d, J= 9.0 Hz, 1H), 4.02 (s, 2H), 3.02 (s, 3H), 2.62 (s, 3H), 2.53 - 2.51 (m, 3H), 1.22 - 1.16 (m, 2H), 1.02 - 0.97 (m, 2H). Regioisomer 2: LC-MS: m/z = 453.2 [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, DMSO-t/ ₆ ) 6 = 9.23 (s, 1H), 8.98 (s, 1H), 8.38 (d, J = 1.8 Hz, 1H), 8.21 (d, J= 3.3 Hz, 1H), 8.19 (d, J = 4.0 Hz, 1H), 7.59 (dd, J= 2.0, 8.9 Hz, 1H), 7.33 (dd, J = 5.8, 8.6 Hz, 2H), 7.09 (d, J = 9.0 Hz, 1H), 3.87 (s, 2H), 3.01 (s, 3H), 2.59 (s, 3H), 2.48 (s, 3H), 1.34 - 1.28 (m, 2H), 1.18 - 1.16 (m, 2H).

Step 6: l-[[[3-(l -hydroxyethyl)-6-[ 6-[ ( 6-methylpyridazin-3-yl)amino ]benzimidazol-l-yl ]-2- pyridyl / -methyl-amino ] methyl cyclopropanecarbonitrile

Prepared in analogy to example 53, step 4 using l-[[[3-acetyl-6-[6-[(6-methylpyridazin-3- yl)amino]benzimidazol-l-yl]-2-pyridyl]-methyl-amino]methyl]c yclopropanecarbonitrile (110.0 mg, 0.240 mmol, 1.0 equiv.) in MeOH:DMF (3:2) to yield l-[[[3-(l-hydroxyethyl)-6-[6-[(6- methylpyridazin-3-yl)amino]benzimidazol-l-yl]-2-pyridyl]-met hyl amino]methyl]cyclopropanecarbonitrile (45.9 mg, 0.100 mmol, 39.1% yield) as light yellow solid . LC-MS: m/z = 455.2 [M+H] ⁺ , ESI pos.

Example 173

1- [[[3-(l-Hydroxyethyl)-6- [5- [(6-methylpyridazin-3-yl)amino] benzimidazol-l-yl]-2- pyridyl] -methyl-amino] methyl] cyclopropanecarbonitrile

Prepared in analogy to example 53, step 4 using l-[[[3-acetyl-6-[5-[(6-methylpyridazin-3- yl)amino]benzimidazol-l-yl]-2-pyridyl]-methyl-amino]methyl]c yclopropanecarbonitrile (110.0 mg, 0.240 mmol, 1.0 equiv., prepared in example 172, step 5) in MeOH:DMF (3:2) to yield 1- [[[3-(l-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino]be nzimidazol-l-yl]-2-pyridyl]- methyl-amino]methyl]cyclopropanecarbonitrile (53.6 mg, 0.120 mmol, 45.4% yield) as light yellow solid. LC-MS: m/z = 455.2 [M+H] ⁺ , ESI pos. Example 174 l-[2-(2-Chloro-5-fluoro-3-pyridyl)-6-[5-[(6-methylpyridazin- 3-yl)amino]benzimidazol-l- yl]-3-pyridyl] ethanol; formic acid Step 1 : 2-chloro-5-fluoro-3-(4, 4, 5, 5-tetramethyl-l, 3, 2-dioxaborolan-2-yl)pyridine

Prepared in analogy to example 143, step 2 using 3-bromo-2-chloro-5-fluoro-pyridine (2.0 g, 9.5 mmol, 1.0 equiv.) to give 2-chloro-5-fluoro-3-(4, 4, 5, 5-tetramethyl-l, 3, 2-dioxaborolan-2- yl)pyridine (2.4 g, 9.22 mmol, 97% yield) as a white solid. LC-MS: m/z = 258.2, [M+H] ⁺ , ESI pos.

Step 2: l-[ 2-(2-chloro-5-fluoro-3-pyridyl)-6-[5-[ ( 6-methylpyridazin-3-yl)amino ]benzimidazol-l- yl] -3-pyridyl ethanone

Prepared in analogy to example 143, step 2 using 2-chloro-5-fhroro-3-(4, 4, 5, 5-tetramethyl-l, 3, 2- dioxaborolan-2-yl)pyridine (84.97 mg, 0.330 mmol, 2.5 equiv.) and l-[2-chloro-6-[5-[(6- methylpyridazin-3-yl)amino]benzimidazol-l-yl]-3-pyridyl]etha none (50.0 mg, 0.130 mmol, 1.0 equiv., prepared in example 76, step 2) to afford l-[2-(2-chloro-5-fluoro-3-pyridyl)-6-[5-[(6- methylpyridazin-3-yl)amino]benzimidazol-l-yl]-3-pyridyl]etha none (25 mg, 0.050 mmol, 39.97% yield) as a yellow solid. LC-MS: m/z = 474.3, [M+H] ⁺ , ESI pos. Step 3: l-[2-(2-chloro-5-fluoro-3-pyridyl)-6-[5-[(6-methylpyridazin- 3-yl)amino]benzimidazol-l- yl] -3-pyridyl ethanol; formic acid

Prepared in analogy to example 53, step 4 using l-[2-(2-chloro-5-fluoro-3-pyridyl)-6-[5-[(6- methylpyridazin-3-yl)amino]benzimidazol-l-yl]-3-pyridyl]etha none and NaBEU (6.01 mg, 0.160 mmol, 5 equiv.) to afford l-[2-(2-chloro-5-fluoro-3-pyridyl)-6-[5-[(6-methylpyridazin- 3- yl)amino]benzimidazol-l-yl]-3-pyridyl]ethanol; formic acid (3.2 mg, 0.010 mmol, 21.2% yield) as a yellow solid. LC-MS: m/z = 476.3 [M+H] ⁺ , ESI pos.

Example 175 l-[3-(l-Hydroxyethyl)-6-[6-[[6-[(3-methoxyazetidin-l-yl)meth yl]pyridazin-3- yl]amino]benzimidazol-l-yl]-2-pyridyl]-5-methyl-pyrazole-3-c arbonitrile;formic acid

Step 1: l-[3-acetyl-6-[5-[[ 6-[(3-methoxyazetidin-l-yl)methyl]pyridazin-3- yl amino ]benzimidazol-l-yl / -2 -pyridyl ]-5-methyl-pyrazole-3-carbonitrile and l-[ 3-acetyl-6-[ 6- [[ 6-[ (3-methoxyazetidin-l-yl)methyl ]pyridazin-3-yl amino ]benzimidazol-l-yl / -2 -pyridyl ]-5- methyl-pyrazole-3-carbonitrile Prepared in analogy to example 64, step 2 using N-[6-[(3-methoxyazetidin-l- yl)methyl]pyridazin-3-yl]-lH-benzimidazol-5-amine (200.0 mg, 0.640 mmol, 1.0 equiv., prepared in example 141, steps 1 and 2) and l-(3-acetyl-6-chloro-2-pyridyl)-5-methyl-pyrazole- 3 -carbonitrile (251.99 mg, 0.970 mmol, 1.5 equiv., prepared in example 64, step 1) to afford 1- [3-acetyl-6-[5-[[6-[(3-methoxyazetidin-l-yl)methyl]pyridazin -3-yl]amino]benzimidazol-l-yl]-2- pyridyl]-5-methyl-pyrazole-3-carbonitrile (40 mg, 0.070 mmol, 11.6% yield) and l-[3-acetyl-6- [6-[[6-[(3-methoxyazetidin-l-yl)methyl]pyridazin-3-yl]amino] benzimidazol-l-yl]-2-pyridyl]-5- methyl-pyrazole-3 -carbonitrile (50 mg, 0.090 mmol, 14.5% yield) as yellow solids. Regioisomer 1 : LC-MS: m/z = 535.1 [M+H] ⁺ , ESI pos. 'HNMR (400 MHz, DMSO-t/ ₆ ) 8 = 9.37 (s, 1H), 9.12 (s, 1H), 8.54 (d, J = 8.5 Hz, 1H), 8.46 (d, J= 2.0 Hz, 1H), 8.30 (d, J= 8.5 Hz, 1H), 8.15 (d, J = 8.9 Hz, 1H), 7.55 (dd, J= 2.0, 9.0 Hz, 1H), 7.40 (d, J= 9.1 Hz, 1H), 7.17 - 7.10 (m, 2H), 3.99 (t, J = 5.8 Hz, 1H), 3.75 (s, 2H), 3.55 - 3.49 (m, 2H), 3.15 (s, 3H), 2.96 (br t, J= 6.7 Hz, 2H), 2.54 (s, 3H), 2.20 (s, 3H). Regioisomer 2: 'H NMR (400 MHz, DMSO-t/ ₆ ) 6 = 9.40 (s, 1H), 9.03 (s, 1H), 9.00 (d, J= 1.9 Hz, 1H), 8.55 (d, J= 8.5 Hz, 1H), 8.28 (d, J= 8.5 Hz, 1H), 7.71 (d, J= 8.6 Hz, 1H), 7.47 (dd, J = 2.1, 8.7 Hz, 1H), 7.37 (d, J= 9.1 Hz, 1H), 7.14 - 7.06 (m, 2H), 4.03 - 3.95 (m, 1H), 3.75 (s, 2H), 3.55 - 3.47 (m, 2H), 3.17 - 3.14 (m, 3H), 2.96 (br dd, J= 5.8, 7.9 Hz, 2H), 2.57 (s, 3H), 2.19 (s, 3H).

Step 2: l-[ 3-( 1 -hydroxyethyl)-6-[ 6-[[ 6-[(3-methoxyazetidin-l-yl)methyl ]pyridazin-3- yl amino ]benzimidazol-l-yl / -2 -pyridyl ]-5-methyl-pyrazole-3-carbonitrile

Prepared in analogy to example 53, step 4 using l-[3-acetyl-6-[5-[[6-[(3-methoxyazetidin-l- yl)methyl]pyridazin-3-yl]amino]benzimidazol-l-yl]-2-pyridyl] -5-methyl-pyrazole-3-carbonitrile (40.0 mg, 0.070 mmol, 1.0 equiv.) in MeOH/DMF (3: 1) to afford l-[3-(l-hydroxyethyl)-6-[6- [[6-[(3-methoxyazetidin-l-yl)methyl]pyridazin-3-yl]amino]ben zimidazol-l-yl]-2-pyridyl]-5- methyl-pyrazole-3-carbonitrile;formic acid (20.7 mg, 0.040 mmol, 49.0% yield) as light brown solid. LC-MS: m/z = 537.2 [M+H] ⁺ , ESI pos. Example 176 l-[3-(l-Hydroxyethyl)-6-[5-[[6-[(3-methoxyazetidin-l-yl)meth yl]pyridazin-3- yl]amino]benzimidazol-l-yl]-2-pyridyl]-5-methyl-pyrazole-3-c arbonitrile Prepared in analogy to example 53, step 4 using l-[3-acetyl-6-[6-[[6-[(3-methoxyazetidin-l- yl)methyl]pyridazin-3-yl]amino]benzimidazol-l-yl]-2-pyridyl] -5-methyl-pyrazole-3-carbonitrile (50.0 mg, 0.090 mmol, 1.0 equiv., prepared in example 175, step 1) in MeOH/DMF (3:1) to afford l-[3-(l-hydroxyethyl)-6-[6-[[6-[(3-methoxyazetidin-l-yl)meth yl]pyridazin-3- yl]amino]benzimidazol-l-yl]-2-pyridyl]-5-methyl-pyrazole-3-c arbonitrile; formic acid (11.9 mg, 0.020 mmol, 23.7% yield) as light yellow solid. LC-MS: m/z = 537.2 [M+H] ⁺ , ESI pos.

Example 177

1- [6- [5- [(6-Methylpyridazin-3-yl)amino] benzimidazol- 1-yl] -2- [5-(oxetan-3-yl)-3- (trifluoromethyl)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-l-yl ]-3-pyridyl]ethanol Step 1: l-[6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-l-yl]-2- [5-(oxetan-3-yl)-3-

(trifluoromethyl)-6, 7-dihydro-4H-pyrazolo[ 4, 3-c ]pyridin-l-yl ]-3-pyridyl ethanone

Prepared in analogy to example 171, step 4 using l-[6-[5-[(6-methylpyridazin-3- yl)amino]benzimidazol-l-yl]-2-[3-(trifluoromethyl)-4,5,6,7-t etrahydropyrazolo[4,3-c]pyridin-l- yl]-3-pyridyl]ethanone; hydrochloride (300.0 mg, 0.530 mmol, 1.0 equiv., example 97, step 3) and 3-oxetanone (195.0 mg, 2.71 mmol, 5.14 equiv.) to give l-[6-[5-[(6-methylpyridazin-3- yl)amino]benzimidazol-l-yl]-2-[5-(oxetan-3-yl)-3-(trifluorom ethyl)-6,7-dihydro-4H- pyrazolo[4,3-c]pyridin-l-yl]-3-pyridyl]ethanone (150 mg, 0.250 mmol, 33.84% yield) as light yellow solid. LC-MS: m/z = 590.2 [M+H] ⁺ , ESI pos.

Step 2: l-[6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-l-yl]-2- [5-(oxetan-3-yl)-3- (trifluoromethyl)-6, 7-dihydro-4H-pyrazolo[ 4, 3-c ]pyridin-l-yl ]-3-pyridyl ethanol

Prepared in analogy to example 53, step 4 using l-[6-[5-[(6-methylpyridazin-3- yl)amino]benzimidazol-l-yl]-2-[5-(oxetan-3-yl)-3-(trifluorom ethyl)-6,7-dihydro-4H- pyrazolo[4,3-c]pyridin-l-yl]-3-pyridyl]ethanone (150.0 mg, 0.180 mmol, 1.0 equiv.) and NaBEU (30.0 mg, 0.790 mmol, 4.5 equiv.) in MeOH/DCM (1:9) to afford l-[6-[5-[(6-methylpyridazin-3- yl)amino]benzimidazol-l-yl]-2-[5-(oxetan-3-yl)-3-(trifluorom ethyl)-6,7-dihydro-4H- pyrazolo[4,3-c]pyridin-l-yl]-3-pyridyl]ethanol (45.2 mg, 0.080 mmol, 42.9% yield) as light yellow solid. LC-MS:m/z = 592.3 [M+H] ⁺ , ESI pos. Example 178

1- [3-(l-Hydroxyethyl)-6- [6- [(6-methylpyridazin-3-yl)amino] benzimidazol-l-yl]-2-pyridyl]- 3-methyl-pyrazole-4-carbonitrile Prepared in analogy to example 53, step 4 using l-[3-acetyl-6-[6-[(6-methylpyridazin-3- yl)amino]benzimidazol-l-yl]-2-pyridyl]-3-methyl-pyrazole-4-c arbonitrile (85.0 mg, 0.190 mmol, 1.0 equiv., preared in example 150, step 2) in MeOH/THF/DCM (1:1:1) to afford l-[3-(l- hydroxyethyl)-6-[6-[(6-methylpyridazin-3-yl)amino]benzimidaz ol-l-yl]-2-pyridyl]-3-methyl- pyrazole-4-carbonitrile (51.8 mg, 0.110 mmol, 60.49% yield) as off-white solid. LC-MS: m/z = 452.1 [M+H] ⁺ , ESI pos.

Example 179

1- [2- [2-(Methylamino)-3-pyridyl]-6- [5- [(6-methylpyridazin-3-yl)amino] benzimidazol- 1-yl] - 3-pyridyl] ethanol; formic acid Step 1: [2-(methylamino)-3-pyridyl]boronic acid

Prepared in analogy to example 143, step 2 using 3-bromo-N-methyl-pyridin-2-amine (1.0 g, 5.35 mmol, 1.0 equiv.) to afford [2-(methylamino)-3-pyridyl]boronic acid (721 mg, 4.69 mmol, 87% yield) as a white solid. LC-MS: m/z = 153.2, [M+H] ⁺ , ESI pos. Step 2: l-[ 2-[ 2-(methylamino)-3-pyridyl ]-6-[5-[ ( 6-methylpyridazin-3-yl)amino ]benzimidazol-l- yl] -3-pyridyl ethanol; formic acid

Prepared in analogy to example 163, Step 3 using [2-(methylamino)-3-pyridyl]boronic acid (159.61 mg, 1.05 mmol, 8.0 equiv.) (used without purification) and l-[2-chloro-6-[5-[(6- methylpyridazin-3-yl)amino]benzimidazol-l-yl]-3-pyridyl]etha nol (50.0 mg, 0.130 mmol, 1.0 equiv, prepared in example 163, step 2) to afford l-[2-[2-(methylamino)-3-pyridyl]-6-[5-[(6- methylpyridazin-3-yl)amino]benzimidazol-l-yl]-3-pyridyl]etha nol; formic acid (17.8 mg, 0.040 mmol, 27.26% yield) as a yellow solid. LC-MS: 453.2, [M+H] ⁺ , ESI pos.

Example 182

1- [3-(l-Hydroxyethyl)-6- [5- [(6-methylpyridazin-3-yl)amino] benzimidazol-l-yl]-2-pyridyl]- 3-methyl-pyrazole-4-carbonitrile

Prepared in analogy to example 53, step 4 using l-[3-acetyl-6-[5-[(6-methylpyridazin-3- yl)amino]benzimidazol-l-yl]-2-pyridyl]-3-methyl-pyrazole-4-c arbonitrile (45.0 mg, 0.100 mmol, 1.0 equiv., prepared in example 178, step 2) in MeOH/THF/DCM (1 :1 : 1) to afford l-[3-(l- hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidaz ol-l-yl]-2-pyridyl]-3-methyl- pyrazole-4-carbonitrile (9.8 mg, 0.020 mmol, 21.3% yield) as off-white solid. LC-MS: m/z =452.1 [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, CD ₃ OD) 5 = 9.06 - 9.01 (m, 1H), 8.98 - 8.92 (m, 1H), 8.55 - 8.49 (m, 1H), 8.26 - 8.22 (m, 1H), 8.20 - 8.15 (m, 1H), 8.05 - 7.99 (m, 1H), 7.70 - 7.65 (m, 1H), 7.43 - 7.37 (m, 1H), 7.21 - 7.13 (m, 1H), 5.61 - 5.51 (m, 1H), 2.56 (s, 3H), 2.52 (s, 3H), 1.52 (d, J = 6.4 Hz, 3H). Example 183

1- [3-(l-Hydroxyethyl)-6- [5- [(6-methylpyridazin-3-yl)amino] benzimidazol-l-yl]-2-pyridyl]-

3-methyl-azetidine-3-carbonitrile

Step 1 : l-(3-acetyl-6-chloro-2-pyridyl)-3-methyl-azetidine-3-carboni trile

Prepared in analogy to example 62, step 1 using 3 -methyl-azetidine-3 -carbonitrile (49.7 mg, 0.374 mmol, 1.0 equiv.) and l-(6-chloro-2-fluoro-3-pyridyl)ethanone (CAS# 1260663-13-5, 65 mg, 0.374 mmol, 1.0 equiv.) yielding the title compound (75 mg, 80.2% yield) as a light brown solid. LC-MS: m/z = 254.16 [M+H] ⁺ , ESI pos.

Step 2: l-[ 3-acetyl-6-[ 6-[ ( 6-methylpyridazin-3-yl)amino ]benzimidazol-l-yl ]-2-pyridyl -3- methyl-azetidine-3-carbonitrile and l-[ 3-acetyl-6-[5-[ ( 6-methylpyridazin-3- yl)amino ]benzimidazol-l-yl / -2 -pyridyl ]-3-methyl-azetidine-3-carbonitrile Prepared in analogy to example 64, step 2 using l-(3-acetyl-6-chloro-2-pyridyl)-3-methyl- azetidine-3 -carbonitrile (72 mg, 0.288 mmol, 1.0 equiv.) and lH-benzimidazol-5-yl-(6- methylpyridazin-3-yl)amine (64.95 mg, 0.288 mmol, 1.0 equiv., prepared in example 64, intermediate 1) to afford : l-[3-acetyl-6-[6-[(6-methylpyridazin-3-yl)amino]benzimidazol -l-yl]- 2-pyridyl] -3 -methyl-azetidine-3 -carbonitrile (30.8 mg, 24.4% yield) and l-[3-acetyl-6-[5-[(6- methylpyridazin-3-yl)amino]benzimidazol-l-yl]-2-pyridyl]-3-m ethyl-azetidine-3-carbonitrile (22.5 mg, 17.8% yield) after separation by SFC (Chiral OJ 250 mm x 20 mm x 10 pm, 25% MeOH (with 0.2% HNEt?), 90 mL/min flow rate). Regioisomer 1 : LC-MS: m/z = 423.2 (M+H) ⁺ , ESI pos. 'H NMR (600 MHz, DMSO-t/ ₆ ) 8 = 9.22 (s, 1 H), 9.03 (s, 1 H), 8.35 (d, J = 8.5 Hz, 1 H), 8.32 (d, J= 2.1 Hz, 1 H), 8.29 (d, J= 8.8 Hz, 1 H), 7.61 (dd, J= 8.9, 2.1 Hz, 1 H), 7.35 (dd, J = 8.7, 7.5 Hz, 2 H), 7.11 (d, J = 9.1 Hz, 1 H), 4.41 (d, J= 9.4 Hz, 2 H), 4.05 (d, J = 9.4 Hz, 2 H), 2.57 (s, 3 H), 2.49 (s, 3 H), 1.67 (s, 3 H). Regioisomer 2: LC-MS: m/z = 423.2 (M+H) ⁺ , ESI pos. 1H NMR (600 MHz, DMSO-t/ ₆ ) 6 = 9.60 (d, J= 1.5 Hz, 1 H), 9.28 - 9.28 (m, 1 H), 9.30 (s, 1 H), 8.96 (s, 1 H), 8.34 (d, J= 8.4 Hz, 1 H), 7.65 (d, J= 8.7 Hz, 1 H), 7.32 - 7.39 (m, 2 H), 7.18 (dd, J= 8.7, 2.2 Hz, 1 H), 7.12 (d, J = 9.0 Hz, 1 H), 4.53 (br d, J= 9.9 Hz, 2 H), 4.17 (br d, J = 9.8 Hz, 2 H), 2.57 (s, 3 H), 2.53 (s, 3 H), 2.40 - 2.40 (m, 1 H), 1.70 (s, 3 H).

Step 3: l-[ 3-( 1 -hydroxyethyl)-6-[5-[ ( 6-methylpyridazin-3-yl)amino ]benzimidazol-l-yl ]-2- pyridyl] -3-methyl-azetidine-3-carbonitrile

Prepared in analogy to example 53, step 4 using l-[3-acetyl-6-[5-[(6-methylpyridazin-3- yl)amino]benzimidazol-l-yl]-2-pyridyl]-3-methyl-azetidine-3- carbonitrile (22.5 mg, 0.051 mmol, 1.0 equiv.) and NaBH4 (2.91 mg, 0.077 mmol, 1.5 equiv.) in THF/'PrOH (1 : 1) to obtain l-[3-(l-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino]be nzimidazol-l-yl]-2-pyridyl]-3- methyl-azetidine-3 -carbonitrile (17 mg, 72.53%) as a white solid. LC-MS: m/z = 441.21 [M+H] ⁺ , ESI pos.

Example 184

1- [3-(l-Hydroxyethyl)-6- [6- [(6-methylpyridazin-3-yl)amino] benzimidazol-l-yl]-2-pyridyl]- 3-methyl-azetidine-3-carbonitrile

Prepared in analogy to example 53, step 4 using l-[3-acetyl-6-[6-[(6-methylpyridazin-3- yl)amino]benzimidazol-l-yl]-2-pyridyl]-3-methyl-azetidine-3- carbonitrile (30.5 mg, 0.070 mmol, 1.0 equiv) and NaBEU (3.95 mg, 0.104 mmol, 1.5 equiv.) in THF/'PrOH (1 : 1) to obtain 1- [3-(l-hydroxyethyl)-6-[6-[(6-methylpyridazin-3-yl)amino]benz imidazol-l-yl]-2-pyridyl]-3- methyl-azetidine-3 -carbonitrile (13.5 mg, 42.61%) as white solid. LC-MS: m/z = 441.21 [M+H] ⁺ , ESI pos.

Example 185 l-[3-(l-Hydroxyethyl)-6-[6-methoxy-5-[(6-methylpyridazin-3-y l)amino]benzimidazol-l-yl]- 2-pyridyl]-5-methyl-pyrazole-3-carbonitrile

Step 1: l-[3-acetyl-6-(5-bromo-6-methoxy-benzimidazol-l-yl)-2-pyridy l]-5-methyl-pyrazole-3- carbonitrile ; formic acid Prepared in analogy to example 64, step 2 using l-(3-acetyl-6-chloro-2-pyridyl)-5-methyl- pyrazole-3 -carbonitrile (1.0 g, 3.84 mmol, 1.0 equiv., prepared in example 64, step 1) and 5- bromo-6-methoxy-lH-benzimidazole (871.03 mg, 3.84 mmol, 1.0 equiv.) and potassium carbonate (1.06 g, 7.67 mmol, 2.0 equiv.) to give l-[3-acetyl-6-(5-bromo-6-methoxy- benzimidazol-l-yl)-2-pyridyl]-5-methyl-pyrazole-3-carbonitri le; formic acid (409.5 mg, 0.820 mmol, 20.4% yield) as orange solid. LC-MS: m/z 452.9 [M+H] ⁺ , ESI pos.

Step 2: l-[ 3-acetyl-6-[ 6-methoxy-5-[ ( 6-methylpyridazin-3-yl)amino ]benzimidazol-l-yl ]-2- pyridyl]-5-methyl-pyrazole-3-carbonitrile

Prepared in analogy to example 104, step 2 using l-[3-acetyl-6-(5-bromo-6-methoxy- benzimidazol-l-yl)-2-pyridyl]-5-methyl-pyrazole-3-carbonitri le; formic acid (50 mg, 0.101 mmol, 1.0 equiv. and, (6-m ethyl pyridazin-3-yl)amine (21.94 mg, 0.201 mmol, 2.0 equiv.) to afford the title compound (30.4 mg, 61.8% yield). LC-MS: m/z = 480.3 [M+H] ⁺ , ESI pos.

Step 3: l-[ 3-( 1 -hydroxyethyl)-6-[ 6-methoxy-5-[ ( 6-methylpyridazin-3-yl)amino ]benzimidazol-l- y I] -2 -pyridyl ]-5-methyl-pyrazole-3-carbonitrile

Prepared in analogy to example 53, step 4 using l-[3-acetyl-6-[6-methoxy-5-[(6- methylpyridazin-3-yl)amino]benzimidazol-l-yl]-2-pyridyl]-5-m ethyl-pyrazole-3-carbonitrile (30.4 mg, 0.062 mmol, 1.0 equiv.) in MeOH/THF (1:1) to afford the title compound (21.6 mg, 71.5% yield). LC-MS: m/z = 480.3 [M+H] ⁺ , ESI pos.

Example 186

1- [6- [5- [(6-Methylpyridazin-3-yl)amino] benzimidazol- 1-yl] -2- [2-(lH-pyrazol-4-yl)-3- pyridyl]-3-pyridyl] ethanol

Step 1 : l-[ 2-[ 2-[ l-[( 4-methoxyphenyl)methyl ]pyrazol-4-yl ]-3-pyridyl ]-6-[5-[ ( 6- methylpyridazin-3-yl)amino ]benzimidazol-l-yl ]-3-pyridyl ethanone Prepared in analogy to example 143, step 2 using l-[2-chloro-6-[5-[(6-methylpyridazin-3- yl)amino]benzimidazol-l-yl]-3-pyridyl]ethanone (70.0 mg, 0.180 mmol, 1.0 equiv., prepared in example 76, step 2), and [2-[l-[(4-methoxyphenyl)methyl]pyrazol-4-yl]-3-pyridyl]boron ic acid (114.24 mg, 0.370 mmol, 2 equiv.) to afford l-[2-[2-[l-[(4-methoxyphenyl)methyl]pyrazol-4- yl]-3-pyridyl]-6-[5-[(6-methylpyridazin-3-yl)amino]benzimida zol-l-yl]-3-pyridyl]ethanone (50 mg, 0.080 mmol, 44.5% yield) as yellow solid. LC-MS: m/z = 608.2 [M+H] ⁺ , ESI pos.

Step 2: l-[6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-l-yl]-2- [2-(lH-pyrazol-4-yl)-3- pyridyl ]-3-pyridyl ] ethanone formic acid

A mixture of l-[2-[2-[l-[(4-methoxyphenyl)methyl]pyrazol-4-yl]-3-pyridyl] -6-[5-[(6- methylpyridazin-3-yl)amino]benzimidazol-l-yl]-3-pyridyl]etha none (45.0 mg, 0.070 mmol, 1.0 equiv.) and 1 mL TFA was stirred at 60 °C for 4 hours. The reaction mixture was concentrated under reduced pressure and the residue was purified by HPLC (Phenomenex Luna Cl 8 (150mm x 40mm x 15 pm). Flow rate: 60 mL / min. Gradient: 10% to 40% CH3CN in (0.225% formic acid in H2O v/v) (13 min) then 100% CH3CN (2 min)) and lyophilized to give l-[6-[5-[(6- methylpyridazin-3-yl)amino]benzimidazol-l-yl]-2-[2-(lH-pyraz ol-4-yl)-3-pyridyl]-3- pyridyl] ethanone (30 mg, 0.060 mmol, 83.1% yield) as yellow solid. LC-MS: m/z = 488.1 [M+H] ⁺ , ESI pos.

Step 3: l-[6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-l-yl]-2- [2-(lH-pyrazol-4-yl)-3- pyridyl ]-3-pyridyl ethanol

Prepared in analogy to example 53, step 4 using l-[6-[5-[(6-methylpyridazin-3- yl)amino]benzimidazol-l-yl]-2-[2-(lH-pyrazol-4-yl)-3-pyridyl ]-3-pyridyl]ethanone (25.0 mg, 0.050 mmol, 1.0 equiv.) and NaBEU (9.75 mg, 0.260 mmol, 5 equiv.) to yield l-[6-[5-[(6- methylpyridazin-3-yl)amino]benzimidazol-l-yl]-2-[2-(lH-pyraz ol-4-yl)-3-pyridyl]-3- pyridyl] ethanol (10.6 mg, 0.020 mmol, 41.5% yield) as a white solid. LC-MS: m/z = 490.2 [M+H] ⁺ , ESI pos. Example 187 l-[3-(l-Hydroxyethyl)-6-[6-(2-methoxyethoxy)-5-[(6-methylpyr idazin-3- yl)amino]benzimidazol-l-yl]-2-pyridyl]-5-methyl-pyrazole-3-c arbonitrile

Step 1: 5-bromo-6-(2-methoxyethoxy)-lH-benzimidazole

A solution of 4-bromo-5-(2-methoxyethoxy)benzene-l,2-diamine (1.6 g, 6.13 mmol, 1.0 equiv.) in trimethyl orthoformate (50.0 mL, 457.03 mmol, 74.59 equiv.) was stirred at 120 °C for 3 hours. The mixture was concentrated in vacuo and the residue was dissolved in THF and IN aq. HC1. The resulting mixture was stirred at 25 °C for 1 hour. The pH was then adjusted to 8 with NaHCCh, and extracted with EtOAc . The combined organic layers were dried over Na2SO4, the volatiles evaporated and the residue was purified by preparative HPLC (Waters Xbridge Cl 8 150 mm x 50 mm x 10 pm, gradient 14 - 4% CH3CN in H2O (with lOmM NH4HCO3) over 11 min, then 100% CH3CN (with lOmM NH4HCO3) (2 min), flow rate 60 mL/min) to yield 5-bromo-6- (2-methoxyethoxy)-lH-benzimidazole (470 mg, 1.73 mmol, 28.29% yield) as yellow solid. LC- MS: m/z = 271.0 [M+H] ⁺ , ESI pos.

Step 2: l-[3-acetyl-6-[5-bromo-6-(2-methoxyethoxy)benzimidazol-l-yl] -2-pyridyl]-5-methyl- pyrazole-3-carbonitrile

Prepared in analogy to example 64, step 2 using 5 -bromo-6-(2-methoxy ethoxy)- 1H- benzimidazole (460.0 mg, 1.7 mmol, 1.0 equiv.) and l-(3-acetyl-6-chloro-2-pyridyl)-5-methyl- pyrazole-3 -carbonitrile (574.99 mg, 2.21 mmol, 1.3 equiv., prepared in example 64, step 1) to afford l-[3-acetyl-6-[5-bromo-6-(2-methoxyethoxy)benzimidazol-l-yl] -2-pyridyl]-5-methyl- pyrazole-3 -carbonitrile (221.5 mg, 0.450 mmol, 23.72% yield) as brown solid. LC-MS: m/z = 495.0 [M+H] ⁺ , ESI pos.

Step 3: l-[ 3-acetyl-6-[ 6-(2-methoxyethoxy)-5-[ ( 6-methylpyridazin-3-yl)amino ]benzimidazol-l- y I] -2 -pyridyl ]-5-methyl-pyrazole-3-carbonitrile

Prepared in analogy to example 104, step 2, using l-[3-acetyl-6-[5-bromo-6-(2- methoxyethoxy)benzimidazol-l-yl]-2-pyridyl]-5-methyl-pyrazol e-3-carbonitrile (50 mg, 0.101 mmol, 1 equiv.), and (6-methylpyridazin-3-yl)amine (22.03 mg, 0.202 mmol, 2.0 equiv., prepared in example 64, intermediate 1) to afford the title compound (35.5 mg, 63.8% yield) as yellow solid. LC-MS: m/z = 524.3 [M+H] ⁺ , ESI pos.

Step 4: l-[ 3-( 1 -hydroxyethyl)-6-[ 6-(2-methoxyethoxy)-5-[ ( 6-methylpyridazin-3- yl)amino ]benzimidazol-l-yl / -2 -pyridyl ]-5-methyl-pyrazole-3-carbonitrile Prepared in analogy to example 53, step 4 using l-[3-acetyl-6-[6-(2-methoxyethoxy)-5-[(6- methylpyridazin-3-yl)amino]benzimidazol-l-yl]-2-pyridyl]-5-m ethyl-pyrazole-3-carbonitrile (35.5 mg, 0.064 mmol, 1.0 equiv.) in MeOH/THF (1:1) to afford the title compound (23.2 mg, 67.2% yield) as yellow solid. LC-MS: m/z = 526.3 [M+H] ⁺ , ESI pos.

Example 188 l-[6-[5-fluoro-6-[[(3R,4S)-4-fluoropyrrolidin-3-yl]amino]ben zimidazol-l-yl]-3-(l- hydroxyethyl)pyridin-2-yl]-5-methylpyrazole-3-carbonitrile

Step 1 : l-[ 3-acetyl-6-[5-fluoro-6-[ [ ( 3S, 4R)-4-fluoropyrrolidin-3-yl ] amino ]benzimidazol-l-yl ]- 2-pyridyl ]-5-methyl-pyrazole-3-carbonitrile;2, 2, 2-trifluoroacetic acid

A solution of tert-butyl (3S,4R)-3-[[3-[5-acetyl-6-(3-cyano-5-methyl-pyrazol-l-yl)-2- pyridyl]-6- fluoro-benzimidazol-5-yl]amino]-4-fluoro-pyrrolidine-l-carbo xylate (40.0 mg, 0.070 mmol, 1.0 equiv., prepared in example 166, step 4) and 0.5 mL TFA in DCM (2.5 mL) was stirred at 25 °C for 1 hour. The mixture was concentrated in vacuo to give crude l-[3-acetyl-6-[5-fluoro-6- [[(3S,4R)-4-fluoropyrrolidin-3-yl]amino]benzimidazol-l-yl]-2 -pyridyl]-5-methyl-pyrazole-3- carbonitrile;2,2,2-trifluoroacetic acid which was used into next step without further purification. LC-MS: m/z = 463.1 [M+H] ⁺ , ESI pos.

Step 2: l-[6-[5-fluoro-6-[[ (3S,4R)-4-fluoropyrrolidin-3-yl]amino]benzimidazol-l-yl]-3-( l- hydroxyethyl)-2-pyridyl]-5-methyl-pyrazole-3-carbonitrile

Prepared in analogy to example 53, step 4 using l-[3-acetyl-6-[5-fluoro-6-[[(3S,4R)-4- fluoropyrrolidin-3-yl]amino]benzimidazol-l-yl]-2-pyridyl]-5- methyl-pyrazole-3- carbonitrile;2, 2, 2-trifluoroacetic acid (as crude from the previous step) to yield l-[6-[5-fluoro-6- [[(3S,4R)-4-fluoropyrrolidin-3-yl]amino]benzimidazol-l-yl]-3 -(l-hydroxyethyl)-2-pyridyl]-5- methyl-pyrazole-3 -carbonitrile (19.1 mg, 0.040 mmol, 37.5% yield) as white solid. LC-MS: m/z = 465.2 [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, DMSO-t/ ₆ ) 8 = 8.88 - 8.77 (m, 1H), 8.44 (d, J= 8.5 Hz, 1H), 8.28 (s, 1H), 8.24 (dd, J= 1.9, 8.5 Hz, 1H), 7.55 (dd, J= 4.6, 8.1 Hz, 1H), 7.50 (d, J= 11.8 Hz, 1H), 7.12 - 6.98 (m, 1H), 5.36 (d, J= 6.9 Hz, 1H), 5.06 - 4.81 (m, 1H), 4.65 - 4.52 (m, 1H), 3.24 - 2.96 (m, 4H), 2.84 (t, J= 9.9 Hz, 1H), 2.33 (d, J= 1.0 Hz, 3H), 2.07 (s, 1H), 1.27 (dd, J= 6.4, 12.0 Hz, 3H).

Example 189

1- [6- [6- [2-(Dimethylamino)ethoxy] -5- [(6-methylpyridazin-3-yl)amino] benzimidazol- 1-yl] -3- (l-hydroxyethyl)-2-pyridyl]-5-methyl-pyrazole-3-carbonitrile

Step 1 : 2-(4, 5-diamino-2-bromo-phenoxy)ethyl-dimethyl-amine

Under an argon atmosphere, 2-(5-amino-2-bromo-4-nitro-phenoxy)ethyl-dimethyl-amine (4.52 g, 13.38 mmol, 1.0 equiv.) was dissolved in ethanol (190 mL). Activated zinc (8.74 g, 133.75 mmol, 10.0 equiv.) was added and the reaction mixture was cooled to 0 °C. A solution containing acetic acid (5.62 g, 5.36 mL, 93.63 mmol, 7.0 equiv.) in ethanol (49.45 mL) was added dropwise while the temperature was kept below 5 °C. The cooling bath was removed, and the reaction mixture was allowed to warm to RT while stirring for another 2 hours. The reaction mixture was filtered, the filter cake rinsed with EtOH, and the combined filtrates evaporated to dryness. The residue was dissolved in Na2COs (2N) and extracted with DCM. The organic layer was washed with brine, dried over MgSCh and the volatiles evaporated. The crude product was purified over SibdU (50 g) using a gradient from 0 - 5% MeOH in DCM to afford the title compound (3.24 g, 83.9% yield) as purple liquid. LC-MS: m/z = 276.1 [M+H] ⁺ , ESI pos.

Step 2: 2-[ ( 6-bromo-3H-benzimidazol-5-yl)oxy ] ethyl-dimethyl-amine A solution of 2-(4,5-diamino-2-bromo-phenoxy)ethyl-dimethyl-amine (3.24 g, 11.82 mmol, 1.0 equiv.) in trimethyl orthoformate (93.56 g, 96.45 mL, 881.62 mmol, 75 equiv.) was stirred at 120 °C for 3 hours. The reaction mixture was evaporated to dryness. The crude product was dissolved in DCM and extracted with aq. HC1 (IN). The aq. layer was cooled, and 4N NaOH solution was added until the solution was basic. The product was extracted with DCM. The organic layer was washed with brine, dried over MgSCU, and the volatiles removed. The crude product was purified by flash column chromatography (SiNEE, 0-5% MeOH in DCM) to yield the title compound (984 mg, 27.8% yield) as light yellow foam. LC-MS: m/z = 285.1 [M+H] ⁺ , ESI pos.

Step 3: l-[3-acetyl-6-[5-bromo-6-[2-(dimethylamino)ethoxy]benzimidaz ol-l-yl]-2-pyridyl]-5- methyl-pyrazole-3-carbonitrile

Prepared in analogy to example 65, step 1 using l-(3-acetyl-6-chloro-2-pyridyl)-5-methyl- pyrazole-3 -carbonitrile (166.05 mg, 0.637 mmol, 1.0 equiv.) and 2-[(6-bromo-3H-benzimidazol- 5-yl)oxy]ethyl-dimethyl-amine (181. mg, 0.637 mmol, 1.0 equiv.) to afford the title compound (62.3 mg, 17.3% yield) as orange solid. LC-MS: m/z = 510.1 [M+H] ⁺ , ESI pos.

Step 4: l-[ 3-acetyl-6-[ 6-[ 2 -(dimethylamino) ethoxy ]-5-[ ( 6-methylpyridazin-3- yl)amino ]benzimidazol-l-yl / -2 -pyridyl ]-5-methyl-pyrazole-3-carbonitrile

Prepared according Example 65, step 2 using l-[3-acetyl-6-[5-bromo-6-[2- (dimethylamino)ethoxy]benzimidazol-l-yl]-2-pyridyl]-5-methyl -pyrazole-3-carbonitrile (41.1 mg, 0.081 mmol, 1.0 equiv.), (6-methylpyridazin-3-yl)amine (17.65 mg, 0.162 mmol, 2.0 equiv.) to afford the title compound (20.5 mg, 44.9% yield) as yellow solid. LC-MS: m/z = 537.3 [M+H] ⁺ , ESI pos.

Step 5: l-[ 6-[ 6-[ 2 -(dimethylamino) ethoxy ]-5-[ ( 6-methylpyridazin-3-yl)amino Jbenzimidazol-1- yl]-3-(l -hydroxyethyl) -2 -pyridyl ]-5-methyl-pyrazole-3-carbonitrile

Prepared according to example 52, step 4 using l-[3-acetyl-6-[6-[2-(dimethylamino)ethoxy]-5- [(6-methylpyridazin-3-yl)amino]benzimidazol-l-yl]-2-pyridyl] -5-methyl-pyrazole-3-carbonitrile (20.5 mg, 0.038 mmol, 1 equiv.) in MeOH/THF (1:1) to yield the title compound (13.3 mg, 63.3% yield) as light yellow solid. LC-MS: m/z = 539.3 [M+H] ⁺ , ESI pos.

Example 190 l-[6-[5-Bromo-6-[4-(oxetan-3-yl)piperazino]benzimidazol-l-yl ]-3-(l-hydroxyethyl)-2- pyridyl]-5-methyl-pyrazole-3-carbonitrile

Prepared according to example 53, step 4 using l-[3-acetyl-6-[5-bromo-6-[4-(oxetan-3- yl)piperazin-l-yl]benzimidazol-l-yl]-2-pyridyl]-5-methyl-pyr azole-3-carbonitrile (30 mg, 0.053 mmol, 1.0 equiv., prepared in example 130, step 4) in MeOH/THF (1:1). LC-MS: m/z = 565.2 [M+H] ⁺ , ESI pos.

Example 191 l-[3-(l-Hydroxyethyl)-6-[5-[[6-(3-methoxyazetidine-l-carbony l)pyridazin-3- yl]amino]benzimidazol-l-yl]-2-pyridyl]-5-methyl-pyrazole-3-c arbonitrile

Step 1: (6-aminopyridazin-3-yl)-(3-methoxyazetidin-l-yl)methanone; 2,2,2-trifluoroacetic acid Under argon atmosphere, N-[6-(3-methoxyazetidine-l-carbonyl)pyridazin-3-yl]carbamic acid tert-butyl ester (88 mg, 0.285 mmol, 1.0 equiv.) was dissolved in DCM (1 mL). TFA (813.6 mg, 550 pL, 7.14 mmol, 25 equiv.) was added, and the reaction mixture was stirred at RT over 1.5 hours. The volatiles were evaporated, and the crude title compound as dark brown oil was used without further purification. LC-MS: m/z = 209.1 [M+H] ⁺ , ESI pos. Step 2: l-[3-acetyl-6-[5-[[6-(3-methoxyazetidine-l-carbonyl)pyridazi n-3- yl amino ]benzimidazol-l-yl / -2 -pyridyl ]-5-methyl-pyrazole-3-carbonitrile

Prepared in analogy to example 104, step 2 using l-[3-acetyl-6-(5-bromobenzimidazol-l-yl)-2- pyridyl]-5-methyl-pyrazole-3-carbonitrile (60 mg, 0.142 mmol, 1.0 equiv., prepared in example 65, step 1) and (6-aminopyridazin-3-yl)-(3-methoxyazetidin-l-yl)methanone; 2,2,2- trifluoroacetic acid (used as crude from the previous step) to afford the title compound (28 mg, 10.8% yield, 30% purity) as yellow oil. LC-MS: m/z = 549.2 [M+H] ⁺ , ESI pos.

Step 3: l-[3-(l-hydroxyethyl)-6-[5-[[6-(3-methoxyazetidine-l-carbony l)pyridazin-3- yl amino ]benzimidazol-l-yl / -2 -pyridyl ]-5-methyl-pyrazole-3-carbonitrile

Prepared in analogy to example 53, step 4 using l-[3-acetyl-6-[5-[[6-(3-methoxyazetidine-l- carbonyl)pyridazin-3-yl]amino]benzimidazol-l-yl]-2-pyridyl]- 5-methyl-pyrazole-3-carbonitrile (28 mg, 0.051 mmol, 1.0 equiv.) to yield the title compound (1.0 mg, 3.6% yield) as white lyophilized powder. LC-MS: m/z = 515.3 [M+H] ⁺ , ESI pos. Example 192 l-[3-(l-Hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino]-6 -pyrrolidin-3-yloxy- benzimidazol-l-yl]-2-pyridyl]-5-methyl-pyrazole-3-carbonitri le

Step 1: tert-butyl 3-[(6-bromo-3H-benzimidazol-5-yl)oxy]pyrrolidine-l-carboxyla te

A mixture of tert-butyl 3-(4,5-diamino-2-bromo-phenoxy)pyrrolidine-l-carboxylate (520.0 mg, 1.4 mmol, 1.0 equiv.) in trimethyl orthoformate (30.0 mL, 274.22 mmol, 196.3 equiv.) was heated to 120 °C for 12 hours. The mixture was concentrated, purified by reversed phase (FA) and lyophilizated to give tert-butyl 3-[(6-bromo-3H-benzimidazol-5-yl)oxy]pyrrolidine-l- carboxylate (447 mg, 1.17 mmol, 78.5% yield) as a red oil. LC-MS: m/z = 326.1 [M-56+H] ⁺ , ESI pos.

Step 2: tert-butyl 3-[3-[5-acetyl-6-(3-cyano-5-methyl-pyrazol-l-yl)-2-pyridyl]- 6-bromo- benzimidazol-5-yl] oxypyrrolidine-1 -carboxylate

Prepared in analogy to example 64, step 2 using tert-butyl 3-[(6-bromo-3H-benzimidazol-5- yl)oxy]pyrrolidine-l -carboxylate (397.0 mg, 1.04 mmol, 1.0 equiv.) and l-(3-acetyl-6-chloro-2- pyridyl)-5-methyl-pyrazole-3-carbonitrile (270.74 mg, 1.04 mmol, 1.0 equiv., prepared in example 64, step 1) to afford tert-butyl 3-[3-[5-acetyl-6-(3-cyano-5-methyl-pyrazol-l-yl)-2- pyridyl]-6-bromo-benzimidazol-5-yl]oxypyrrolidine-l-carboxyl ate (131.5 mg, 0.220 mmol, 20.0% yield) as an off-white solid. LC-MS: m/z = 605.9 [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, CD ₃ OD) 5 = 8.94 (s, 1H), 8.53 (br d, J= 8.0 Hz, 1H), 8.16 (br d, J= 8.0 Hz, 1H), 7.98 (s, 2H), 6.91 (s, 1H), 5.01 (br s, 1H), 3.61 - 3.51 (m, 4H), 2.53 (s, 3H), 2.27 (s, 3H), 1.47 (br d, J = 16.0 Hz, 9H)

Step 3: 3-[3-[5-acetyl-6-(3-cyano-5-methyl-pyrazol-l-yl)-2-pyridyl]- 6-[(6-methylpyridazin-3- yl)amino]benzimidazol-5-yl] oxypyrrolidine-1 -carboxylic acid tert-butyl ester

Prepared in analogy to example 104, step 2 using 3-[3-[5-acetyl-6-(3-cyano-5-methyl-pyrazol-l- yl)-2-pyridyl]-6-bromo-benzimidazol-5-yl]oxypyrrolidine-l -carboxylic acid tert-butyl ester (50 mg, 0.082 mmol, 1.0 equiv.) and (6-m ethyl pyridazin-3-yl)amine (17.99 mg, 0.165 mmol, 2.0 equiv.) to afford the title compound (35.4 mg, 67.7% yield) as yellow solid. LC-MS: m/z = 635.4 [M+H] ⁺ , ESI pos.

Step 4: 3-[3-[ 6-(3-cyano-5-methyl-pyrazol-l-yl)-5-( 1 -hydroxyethyl) -2 -pyridyl ]-6-[ ( 6- methylpyridazin-3-yl)amino ]benzimidazol-5-yl oxypyrrolidine-l-carboxylic acid tert-butyl ester

Prepared in analogy to example 53, step 4 using 3-[3-[5-acetyl-6-(3-cyano-5-methyl-pyrazol-l- yl)-2-pyridyl]-6-[(6-methylpyridazin-3-yl)amino]benzimidazol -5-yl]oxypyrrolidine-l -carboxylic acid tert-butyl ester (35.4 mg, 0.056 mmol, 1 equiv.) in MeOH/THF (1 : 1) to afford the title compound (31.0 mg, 82.9% yield) as light yellow solid. LC-MS: 637.4 [M+H] ⁺ , ESI pos.

Step 5: l-[3-(l -hydroxyethyl)-6-[5-[ ( 6-methylpyridazin-3-yl)amino ] -6-pyrrolidin-3-yloxy- benzimidazol-l-yl] -2-pyridyl] -5-methyl-pyrazole-3-carbonitrile

To a stirred solution of 3-[3-[6-(3-cyano-5-methyl-pyrazol-l-yl)-5-(l-hydroxyethyl)-2 -pyridyl]- 6-[(6-methylpyridazin-3-yl)amino]benzimidazol-5-yl]oxypyrrol idine-l-carboxylic acid tert-butyl ester (31 mg, 0.049 mmol, 1 equiv.) at RT in DCM (0.231 mL) was added TFA (111 mg, 75 pL, 0.974 mmol, 20 equiv.). Stirring was continued at 23 °C for 2 hours. The reaction mixture was cooled to 0 °C, 20 mL aq. NaHCCL sol. (pH = 8) was added carfuelly. The mixture was extracted with DCM, the organic layers washed with brine, dried over MgSCh, and evaporated to dryness. The crude product was purified by falsh column chromatography (SiNH2, 2-10% MeOH in DCM) to afford the title compound (17 .0 mg, 60.5% yield) as light yellow solid. LC-MS: m/z = 537.3 [M+H] ⁺ , ESI pos. Example 193

1- [3-(l-Hydroxyethyl)-6- [5- [ [6-(2-methoxyethoxy)pyridazin-3-yl] amino] benzimidazol- 1-yl] - 2-pyridyl]-5-methyl-pyrazole-3-carbonitrile

Step 1: 3-chloro-6-(2-methoxyethoxy)pyridazine

To a solution of 2-methoxyethanol (776.0 mg, 10.2 mmol, 0.990 equiv.) in THF (15 mL) was added NaH (492.95 mg, 12.32 mmol, 1.2 equiv.) in portions under nitrogen atmosphere at 0 °C. The mixture was stirred at 0 °C for 30 min. Then 3,6-dichloropyridazine (1.53 g, 10.27 mmol, 1.0 equiv.) was added dropwise. The reaction mixture was stirred at 0 °C for another hour. The reaction mixture was quenched by addition of sat. aq. NH4CI at 0 °C, and then diluted with EtOAc. The layers were separated and the aqueous layer washed further with EtOAc. The combined organic layers were filtered and concentrated under reduced pressure. The residue was purified by flash column chromatography (silica gel, 25% EtOAc in PE to yield 3-chloro-6-(2- methoxyethoxy)pyridazine (1.6 g, 8.48 mmol, 82.6% yield) as a colourless oil. ^J H NMR (400 MHz, CDCI3) 8 = 7.44 - 7.33 (m, 1H), 7.12 - 6.99 (m, 1H), 4.73 - 4.57 (m, 2H), 3.87 - 3.74 (m, 2H), 3.45 (s, 3H).

Step 2: tert-butyl N-[6-(2-methoxyethoxy)pyridazin-3-yl] carbamate To a brown turbid mixture of 3-chloro-6-(2-methoxyethoxy)pyridazine (1.0 g, 5.3 mmol, 1.0 equiv.), Pd2(dba)s (485.51 mg, 0.530 mmol, 0.10 equiv.) in 1,4-dioxane (15 mL) were added tert-butyl carbamate (1.24 g, 10.6 mmol, 2.0 equiv.), CS2CO3 (3.45 g, 10.6 mmol, 2.0 equiv.) and 9,9-dimethyl-4,5-bis(diphenylphosphino)xanthene (613.57 mg, 1.06 mmol, 0.20 equiv.). The reaction mixture was heated to 90 °C and stirred for 3 h under nitrogen atmosphere. The mixture was poured into water, and the aqueous phase was extracted with EtOAc. The combined organic layers were washed with, dried over ISfeSCU and concentrated under vacuum. The residue was purified by flash column chromatography (silica gel, 33% EtOAc in PE) to yield tert-butyl N-[6- (2-methoxyethoxy)pyridazin-3-yl]carbamate (800 mg, 2.97 mmol, 56.0% yield) as off-white solid. The reaction was successful. LC-MS: m/z = 231.7 [M+H] ⁺ , ESI pos.

Step 3: 6-(2-methoxyethoxy)pyridazin-3-amine;2,2,2-trifluoroacetic acid

A solution of tert-butyl N-[6-(2-methoxyethoxy)pyridazin-3-yl]carbamate (700.0 mg, 2.6 mmol, 1.0 equiv.) in trifluoroacetic acid (10.0 mL, 129.8 mmol, 50 equiv.) was stirred at 0 °C for 2 hours. The reaction mixture was concentrated under vacuum. The residue was triturated with PE/EtOAc (10: 1) and filtered. The filter cake was dried to give 6-(2-methoxyethoxy)pyridazin-3- amine;2,2,2-trifluoroacetic acid (650.9 mg, 2.3 mmol, 88.4% yield) as off-white solid. LC-MS: m/z = 168.9 [M+H] ⁺ , ESI pos.

Step 4: l-[3-acetyl-6-[5-[[ 6-(2-methoxyethoxy)pyridazin-3-yl] amino] benzimidazol-l-yl] -2- pyridyl]-5-methyl-pyrazole-3-carbonitrile

Prepared in analogy to example 104, step 2 using l-[3-acetyl-6-(5-bromobenzimidazol-l-yl)-2- pyridyl]-5-methyl-pyrazole-3-carbonitrile (30 mg, 0.071 mmol, 1.0 equiv., prepared in example 65, step 1), [6-(2-methoxyethoxy)pyridazin-3-yl]amine;2,2,2-trifluoroacet ic acid (40.34 mg, 0.142 mmol, 2.0 equiv.) to afford the title compound (19.3 g, 50.5% yield) as yellow solid. LC- MS: m/z = 510.3 [M+H] ⁺ , ESI pos.

Step 5: l-[ 3-( 1 -hydroxyethyl)-6-[5-[[ 6-(2-methoxyethoxy)pyridazin-3-yl ] amino ]benzimidazol-l- y I] -2 -pyridyl ]-5-methyl-pyrazole-3-carbonitrile

Prepared in analogy to example 53, step 4 using l-[3-acetyl-6-[5-[[6-(2- methoxyethoxy)pyridazin-3-yl]amino]benzimidazol-l-yl]-2-pyri dyl]-5-methyl-pyrazole-3- carbonitrile (19.3 mg, 0.036 mmol, 1.0 equiv.) in MeOH/THF (1:1) to afford the title compound (14.8 mg, 78.8% yield) as a white solid. LC-MS: m/z = 512.3 [M+H] ⁺ , ESI pos.

Example 194 l-[2-(lH-Benzotriazol-4-yl)-6-[5-[(6-methylpyridazin-3-yl)am ino]benzimidazol-l-yl]-3- pyridyl] ethanol

Prepared in analogy to example 163, step 3 using l-[2-chloro-6-[5-[(6-methylpyridazin-3- yl)amino]benzimidazol-l-yl]-3-pyridyl]ethanol (30.0 mg, 0.080 mmol, 1.0 equiv., prepared in example 163, step 2) and lH-benzotriazol-4-ylboronic acid (25.67 mg, 0.160 mmol, 2 equiv.) to yield l-[2-(lH-benzotriazol-4-yl)-6-[5-[(6-methylpyridazin-3-yl)am ino]benzimidazol-l-yl]-3- pyridyl] ethanol (1.3 mg, 3.2% yield) as a white solid. LC-MS: m/z = 464.2 [M+H] ⁺ , ESI pos. Example 195

1- [6- [5- [[6-(2,2-Difluoroethoxy)pyridazin-3-yl]amino] benzimidazol-l-yl]-3-(l- hydroxyethyl)-2-pyridyl]-5-methyl-pyrazole-3-carbonitrile

Step 1: 3-chloro-6-(2,2-difluoroethoxy)pyridazine

Prepared in analogy to example 193, step 1, using 2,2-difluoroethanol (600.0 mg, 7.31 mmol, 1.0 equiv.), sodium hydride (444.0 mg, 11.1 mmol, 1.5 equiv.), and 3,6-dichloropyridazine (1090.18 mg, 7.32 mmol, 1.0 equiv.) to afford 3-chloro-6-(2,2-difluoroethoxy)pyridazine (1000 mg, 5.14 mmol, 70.3% yield) as white solid. LC-MS: m/z = 195.1[M+H] ⁺ , ESI pos.

Step 2: tert-butyl N-[6-(2,2-difluoroethoxy)pyridazin-3-yl] carbamate

Prepared in analogy to example 193, step 2, using 3-chloro-6-(2,2-difluoroethoxy)pyridazine (900.0 mg, 4.63 mmol, 1.0 equiv.) and tert-butyl carbamate (812.83 mg, 6.94 mmol, 1.5 equiv.) to afford tert-butyl N-[6-(2,2-difluoroethoxy)pyridazin-3-yl]carbamate (390 mg, 1.42 mmol, 30.6% yield) as white solid. LC-MS: m/z = 220.1 [M-'Bu+H] , ESI pos.

Step 3: 6-(2,2-difluoroethoxy)pyridazin-3-amine Prepared in analogy to example 193, step 3, using tert-butyl N-[6-(2,2-difluoroethoxy)pyridazin- 3-yl]carbamate (370.0 mg, 1.34 mmol, 1.0 equiv.) to afford 6-(2,2-difluoroethoxy)pyridazin-3- amine (170.5 mg, 0.970 mmol, 72.42% yield) as white solid. LC-MS: m/z = 176.1 [M+H] ⁺ , ESI pos.

Step 4: l-[ 3-acetyl-6-[5-[[ 6-(2, 2-difluoroethoxy)pyridazin-3-yl amino ]benzimidazol-l-yl -2- pyridyl]-5-methyl-pyrazole-3-carbonitrile

Prepared in analogy to example 104, step 2 using l-[3-acetyl-6-(5-bromobenzimidazol-l-yl)-2- pyridyl]-5-methyl-pyrazole-3-carbonitrile (30 mg, 0.071 mmol, 1.0 equiv., prepared in example 65, step 1) and [6-(2,2-difluoroethoxy)pyridazin-3-yl]amine (24.95 mg, 0.142 mmol, 2.0 equiv. )to afford the title compound (38.5 mg, 83.9% yield ) as light yellow solid. LC-MS: m/z = 516.3 [M+H] ⁺ , ESI pos.

Step 5: l-[ 6-[5-[[ 6-(2, 2-difluoroethoxy)pyridazin-3-yl amino ]benzimidazol-l-yl -3-( 1 - hydroxyethyl)-2-pyridyl]-5-methyl-pyrazole-3-carbonitrile

Prepared in analogy to example 53, step 4, using l-[3-acetyl-6-[5-[[6-(2,2- difluoroethoxy)pyridazin-3-yl]amino]benzimidazol-l-yl]-2-pyr idyl]-5-methyl-pyrazole-3- carbonitrile (38.5 mg, 0.060 mmol, 1.0 equiv.) in MeOH/THF (1:1) to afford the title compound (22.1 mg, 67.9% yield) as light yellow solid. LC-MS: m/z = 518.3 [M+H] ⁺ , ESI pos. Example 197 l-[6-[5-[[6-(Difluoromethoxy)pyridazin-3-yl]amino]benzimidaz ol-l-yl]-3-(l-hydroxyethyl)-

2-pyridyl]-5-methyl-pyrazole-3-carbonitrile

Step 1: 6-(difluoromethoxy)pyridazin-3-amine

To a solution of 6-aminopyridazin-3(2H)-one (1.24 g, 11.16 mmol, 1.0 equiv.) in CH3CN (20 mL) was added 2,2-difluoro-2-(fluorosulfonyl)acetic acid (2.39 g, 13.39 mmol, 1.2 equiv.). The mixture was stirred at 20 °C for 48 h. The reaction solution was concentrated under reduced pressure and the crude was purified by preparative HPLC (Phenomenex luna Cl 8 150 mm x 25mm x 10 pm, gradient 1 - 15% CH3CN in H2O (with 0.225% formic acid) over 20 min, then 100% CH3CN (2 min), flow rate 140 mL/min, 1 injection) to give the 6- (difhioromethoxy)pyridazin-3-amine (169.6 mg, 1.05 mmol, 9.2% yield) as brown gum. LC-MS: m/z = 162.0 [M+H] ⁺ , ESI pos. Step 2: l-[3-acetyl-6-[5-[[ 6-(difluoromethoxy)pyridazin-3-yl] amino] benzimidazol-l-yl] -2- pyridyl]-5-methyl-pyrazole-3-carbonitrile Prepared in analogy to example 104, step 2, using l-[3-acetyl-6-(5-bromobenzimidazol-l-yl)-2- pyridyl]-5-methyl-pyrazole-3-carbonitrile (30 mg, 0.071 mmol, 1.0 equiv. prepared in example 65, step 1) and [6-(difluoromethoxy)pyridazin-3-yl]amine (22.95 mg, 0.142 mmol, 2.0 equiv.) to afford the title compound (24.1 mg, 64.1% yield) as yellow solid. LC-MS: m/z = 502.3 [M+H] ⁺ , ESI pos.

Step 3: l-[ 6-[5-[[ 6-(difluoromethoxy)pyridazin-3-yl ] amino ]benzimidazol-l-yl ]-3-( 1 - hydroxyethyl)-2-pyridyl]-5-methyl-pyrazole-3-carbonitrile

Prepared in analogy to example 53, step 4 using l-[3-acetyl-6-[5-[[6- (difluoromethoxy)pyridazin-3-yl]amino]benzimidazol-l-yl]-2-p yridyl]-5-methyl-pyrazole-3- carbonitrile (24.1 mg, 0.046 mmol, 1.0 equiv.) in MeOH/THF (1:1) to yield the title compound

(19.3 mg, 79.8% yield) as off-white solid. LC-MS: m/z = 504.3 [M+H] ⁺ , ESI pos.

Example 198 l-[3-(2,2-Difluoro-l-hydroxy-ethyl)-6-[5-[(6-methylpyridazin -3-yl)amino]benzimidazol-l- yl]-2-pyridyl]-5-methyl-pyrazole-3-carbonitrile Step 1 : l-[ 6-chloro-3-( 4, 4, 4-trifluoro-3-oxo-butanoyl)-2-pyridyl / -5-methyl-pyrazole-3- carbonitrile

To a solution of l-(3-acetyl-6-chloro-2-pyridyl)-5-methyl-pyrazole-3-carbonit rile (3.53 g, 11.51 mmol, 1.0 equiv., prepared in example 64, step 1) in THF (35 mL) was added LiHMDS (23.0 mL, 23.02 mmol, 2.0 equiv.) dropwise at -70 °C. The reaction mixture was stirred at -70 °C for 1 h. To the reaction mixture was added ethyl trifluoroacetate (1.64 g, 11.51 mmol, 1.0 equiv.) in THF (10 mL) dropwise at -70 °C. The reaction mixture was stirred at RT for 2 hours. The reaction mixture was added into sat. aq. NH4CI and extracted with EtOAc. The combined organic layers were concentrated under reduced pressure. The residue was purified by flash column chromatography (silica gel, 10 - 25% EtOAc in PE) to yield 1 -[6-chl oro-3 -(4,4,4- trifluoro-3-oxo-butanoyl)-2-pyridyl]-5-methyl-pyrazole-3-car bonitrile (1.4 g, 3.92 mmol, 34.1% yield) as brown oil. LC-MS: m/z = 357.1 [M+H] ⁺ , ESI pos.

Step 2: l-[ 6-chloro-3-(2, 2 -difluoroacetyl) -2 -pyridyl ]-5-methyl-pyrazole-3-carbonitrile

A solution of l-[6-chloro-3-(4,4,4-trifluoro-3-oxo-butanoyl)-2-pyridyl]-5- methyl-pyrazole-3- carbonitrile (3.2 g, 8.07 mmol, 1.0 equiv.) in CH3CN (60 mL) was added l-chloromethyl-4- fluoro-l,4-diazoniabicyclo[2.2.2]octane (7.15 g, 20.19 mmol, 2.5 equiv.) portionwise at 15 °C. Then the mixture was stirred at 90 °C for 1 hour. The mixture was cooled to RT, and TEA (5.6 mL, 40.37 mmol, 5.0 equiv.) and water (0.29 mL, 16.15 mmol, 2.0 equiv.) were added at RT and stirred for 1.5 hours. The reaction mixture was diluted with water and extracted withEtOAc. The combined extracts were washed with brine, dried over ISfeSCU and concentrated to yield crude 1- [6-chloro-3-(2,2-difluoroacetyl)-2-pyridyl]-5-methyl-pyrazol e-3-carbonitrile as brown oil which was used without further purification. LC-MS: m/z = 296.9 [M+H] ⁺ , ESI pos. Step 3: l-[ 6-chloro-3-(2, 2-difluoro-l-hydroxy-ethyl)-2-pyridyl / -5-methyl-pyrazole-3- carbonitrile

To a solution of l-[6-chloro-3-(2,2-difluoroacetyl)-2-pyridyl]-5-methyl-pyraz ole-3-carbonitrile (used as crude from the previous step) in THF (30 mL) was added NaBTLj (918.21 mg, 24.27 mmol, 3.0 equiv.) at 0 °C in portions. After the addition was complete, the mixture was stirred at 0 °C for 1 h. The mixture was quenched with sat. aq. NH4CI and extracted with EtOAc. The combined organic layers were dried over ISfeSCU and concentrated. The crude product was purified by flash column chromatography (silica gel. 0 - 20% EtOAc in PE) to yield l-[6-chloro- 3-(2,2-difluoro-l-hydroxy-ethyl)-2-pyridyl]-5-methyl-pyrazol e-3-carbonitrile (1.7 g, 5.69 mmol, 70.4% yield) as light yellow solid. LC-MS: m/z = 299.0 [M+H] ⁺ , ESI pos.

Step 4: l-[ 3-(2, 2-difluoro-l-hydroxy-ethyl)-6-[5-[ ( 6-methylpyridazin-3-yl)amino ]benzimidazol- 1-yl ]-2-pyridyl ]-5-methyl-pyrazole-3-carbonitrile and l-[ 3-(2, 2-difluoro-l-hydroxy-ethyl)-6-[ 6- [ ( 6-methylpyridazin-3-yl)amino ]benzimidazol-l-yl / -2 -pyridyl ]-5-methyl-pyrazole-3-carbonitrile

Prepared in analogy to example 64, step 2, using N-(6-methylpyridazin-3-yl)-lH-benzimidazol- 5-amine (177.45 mg, 0.670 mmol, 1.0 equiv., prepared in example 64, intermediate 1) and l-[6- chloro-3-(2,2-difluoro-l-hydroxy-ethyl)-2-pyridyl]-5-methyl- pyrazole-3-carbonitrile (200.0 mg, 0.670 mmol, 1.0 equiv.). The crude was purified by preparative HPLC (Phenomenex luna C18 (250x70mm, 10 um), water (0.225%FA) - CH3CN, 12 - 42% B, gradient time 20 min, 2 min 100% B hold time, flow rate 25 mL/min) followed by preparative NPLC (Waters Xbridge 150 x 25mm x 5um), Hexane - EtOH (0.1% ammonium hydroxide), 10 - 50% B, gradient time 15 min, 5 min 100% B hold time, flow rate 100 mL/min, 1 injection) to separate the regioisomers. l-[3-(2,2-difluoro-l-hydroxy-ethyl)-6-[5-[(6-methylpyridazin -3-yl)amino]benzimidazol-l-yl]-2- pyridyl]-5-methyl-pyrazole-3-carbonitrile (3.7 mg, 0.010 mmol, 1.13% yield) was obtained as white solid after further purification by preparative HPLC (Phenomenex luna Cl 8 (250x70mm, 10 um), water (10 mM NH4HCO3) - CH3CN, 28 - 58% B, flow rate 25 mL/min, 1 injection). LC-MS: m/z = 488.1 [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, DMSO-t/ ₆ ) 8 = 9.25 (s, 1H), 9.05 (s, 1H), 8.50 - 8.42 (m, 2H), 8.32 (d, J= 8.6 Hz, 1H), 8.06 (d, J = 8.9 Hz, 1H), 7.55 - 7.46 (m, 1H), 7.33 (d, J = 9.0 Hz, 1H), 7.15 - 7.03 (m, 2H), 6.84 - 6.58 (m, 1H), 6.32 - 5.95 (m, 1H), 4.86 (dt, J= 3.4, 11.6 Hz, 1H), 2.48 (s, 3H), 2.36 (s, 3H).

Example 199 l-[3-(2,2-Difluoro-l-hydroxy-ethyl)-6-[6-[(6-methylpyridazin -3-yl)amino]benzimidazol-l- yl]-2-pyridyl]-5-methyl-pyrazole-3-carbonitrile

1 -[3 -(2,2-difluoro- 1 -hy droxy-ethyl)-6-[6-[(6-m ethyl pyridazin-3 -yl)amino]benzimidazol- 1 -yl] -2- pyridyl]-5-methyl-pyrazole-3-carbonitrile (6.1 mg, 0.010 mmol, 1.8% yield) was obtained as yellow solid after separation of the regioisomers by preparative NPLC (Waters Xbridge 150 x 25mm x 5um), Hexane - EtOH (0.1% ammonium hydroxide), 10 - 50% B, gradient time 15 min, 5 min 100% B hold time, flow rate 100 mL/min, 1 injection) in example 198, step 4. LC- MS: m/z = 488.3 [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, CD3OD) 5 = 8.83 (br s, 2H), 8.61 (d, J = 8.5 Hz, 1H), 8.20 (d, J = 8.5 Hz, 1H), 7.70 (d, J = 8.5 Hz, 1H), 7.45 (dd, J= 1.7, 8.6 Hz, 1H), 7.40 - 7.31 (m, 1H), 7.13 (br d, J= 9.1 Hz, 1H), 6.82 (s, 1H), 6.16 - 5.80 (m, 1H), 5.08 - 5.00 (m, 1H), 2.56 (s, 3H), 2.41 (s, 3H).

Example 201 l-[6-[5-[(l,l-Dioxo-l,2-thiazolidin-2-yl)methyl]benzimidazol -l-yl]-3-(l-hydroxyethyl)-2- pyridyl]-5-methyl-pyrazole-3-carbonitrile

Step 1: 2-[ [5-[(l,l-dioxo-l, 2-thiazolidin-2-yl)methyl]benzimidazol-l-yl] methoxy] ethyl- trimethyl-silane

To a solution of 2-[[5-(chloromethyl)benzimidazol-l-yl]methoxy]ethyl-trimethy l-silane (500.0 mg, 1.68 mmol, 1.0 equiv., prepared in example 212, step 3) in DMSO (10 mL) was added 1,3- propanesultam (245.0 mg, 2.02 mmol, 1.2 equiv.) and K2CO3 (698.29 mg, 5.05 mmol, 3 equiv.). The reaction mixture was stirred at 30 °C for 2 h. The reaction mixture was diluted with water and was extracted with EtOAc. The organic layer was washed with brine and concentrated under reduced pressure to yield 2-[[5-[(l,l-dioxo-l,2-thiazolidin-2-yl)methyl]benzimidazol-l - yl]methoxy]ethyl-trimethyl-silane (600 mg, 1.57 mmol, 93.4% yield) as yellow oil. LC-MS: m/z = 382.2 [M+H] ⁺ , ESI pos.

Step 2: 2-(lH-benzimidazol-5-ylmethyl)-l,2-thiazolidine 1,1 -dioxide

A solution of 2-[[5-[(l,l-dioxo-l,2-thiazolidin-2-yl)methyl]benzimidazol-l -yl]methoxy]ethyl- trimethyl-silane (500.0 mg, 1.31 mmol, 1.0 equiv.) in TFA (5.0 mL) was stirred at 20 °C for 2 h. The reaction mixture was concentrated under reduced pressure. The residue was purified by preparative TLC (10% MeOH in DCM) to yield 2-(lH-benzimidazol-5-ylmethyl)-l,2- thiazolidine 1,1-dioxide (250 mg, 0.990 mmol, 75.9% yield) as colorless oil. LC-MS: m/z = 252.0 [M+H] ⁺ , ESI pos. Step 3: l-[ 3-acetyl-6-[ 6-[ ( 1, 1 -dioxo- 1, 2-thiazolidin-2-yl)methyl ]benzimidazol-l-yl ]-2-pyridyl ]- 5-methyl-pyrazole-3-carbonitrile and l-[3-acetyl-6-[5-[(l, 1 -dioxo- 1,2 -thiazolidin-2- yl)methyl ]benzimidazol-l-yl / -2 -pyridyl ]-5-methyl-pyrazole-3-carbonitrile

Prepared in analogy to example 64, step 2, using l-(3-acetyl-6-chloro-2-pyridyl)-5-methyl- pyrazole-3 -carbonitrile (248.96 mg, 0.960 mmol, 1.0 equiv., prepared in example 64, step 1) and 2-(lH-benzimidazol-5-ylmethyl)-l,2-thiazolidine 1,1-dioxide (240.0 mg, 0.960 mmol, 1.0 equiv.) to give l-[3-acetyl-6-[5-[(l,l-dioxo-l,2-thiazolidin-2-yl)methyl]ben zimidazol-l-yl]-2- pyridyl]-5-methyl-pyrazole-3-carbonitrile (150 mg, 0.320 mmol, 33.0% yield) as yellow oil and l-[3-acetyl-6-[6-[(l, 1 -di oxo-1, 2-thi azolidin-2 -yl)methyl]benzimidazol- 1 -yl]-2-pyri dyl]-5- methyl-pyrazole-3 -carbonitrile (150 mg, 0.320 mmol, 33.0% yield) as yellow oil after separation by prepative TLC (10% MeOH in DCM). Regioisomer 1 : LC-MS: m/z = 476.1 [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, DMSO-t/ ₆ ) 8 = 9.15 (s, 1H), 8.57 (br d, J= 8.7 Hz, 1H), 8.36 - 8.22 (m, 2H), 7.79 (br d, J= 7.3 Hz, 1H), 7.37 (br d, J= 7.9 Hz, 1H), 7.15 (s, 1H), 4.23 (s, 2H), 3.26 - 3.20 (m, 2H), 3.09 (br t, J= 6.2 Hz, 2H), 2.57 (s, 3H), 2.26 - 2.12 (m, 5H). Regioisomer 2: LC- MS: m/z = 476.1 [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, DMSO-t/ ₆ ) 6 = 9.15 (s, 1H), 8.56 (br d, J= 8.2 Hz, 1H), 8.31 (br d, J= 8.3 Hz, 1H), 8.20 (br d, J= 8.4 Hz, 1H), 7.78 (s, 1H), 7.40 (br d, J= 8.7 Hz, 1H), 7.13 (s, 1H), 4.23 (s, 2H), 3.26 (br t, J= 7.5 Hz, 2H), 3.11 (br t, J= 6.3 Hz, 2H), 2.53 (s, 3H), 2.21 (s, 5H).

Step 4: l-[ 6-[5-[ ( 1, 1 -dioxo- 1, 2-thiazolidin-2-yl)methyl ]benzimidazol-l-yl ]-3-( 1 -hydroxyethyl)-2- pyridyl]-5-methyl-pyrazole-3-carbonitrile

Prepared in analogy to example 53, step 4, using l-[3-acetyl-6-[5-[(l,l-dioxo-l,2-thiazolidin-2- yl)methyl]benzimidazol-l-yl]-2-pyridyl]-5-methyl-pyrazole-3- carbonitrile (150.0 mg, 0.320 mmol, 1.0 equiv.) in MeOH/THF (1 : 1) to afford l-[6-[5-[(l,l-dioxo-l,2-thiazolidin-2- yl)methyl]benzimidazol-l-yl]-3-(l-hydroxyethyl)-2-pyridyl]-5 -methyl-pyrazole-3-carbonitrile (41.3 mg, 0.090 mmol, 26.8% yield) as white solid. LC-MS: m/z = 478.2 [M+H] ⁺ , ESI pos. ^J H NMR (400 MHz, DMSO-t/ ₆ ) 8 = 9.07 (s, 1H), 8.48 (d, J= 8.4 Hz, 1H), 8.29 (d, J= 8.4 Hz, 1H), 8.11 (d, .7= 8.4 Hz, 1H), 7.77 (d, J= 0.7 Hz, 1H), 7.37 (dd, J= 1.4, 8.5 Hz, 1H), 7.11 (d, J = 0.7 Hz, 1H), 5.56 (d, J= 4.4 Hz, 1H), 4.63 - 4.54 (m, 1H), 4.23 (s, 2H), 3.30 - 3.24 (m, 2H), 3.10 (t, J= 6.7 Hz, 2H), 2.35 (s, 3H), 2.26 - 2.17 (m, 2H), 1.27 (d, J= 6.4 Hz, 3H).

Example 202 l-[6-[6-[(l,l-Dioxo-l,2-thiazolidin-2-yl)methyl]benzimidazol -l-yl]-3-(l-hydroxyethyl)-2- pyridyl]-5-methyl-pyrazole-3-carbonitrile

Prepared in analogy to example 53, step 4, using l-[3-acetyl-6-[6-[(l,l-dioxo-l,2-thiazolidin-2- yl)methyl]benzimidazol-l-yl]-2-pyridyl]-5-methyl-pyrazole-3- carbonitrile (150.0 mg, 0.320 mmol, 1.0 equiv., obtained in example 201, step 3) MeOH/THF (1 :1) to afford l-[6-[6-[(l,l- di oxo-1, 2-thiazolidin-2-yl)methyl]benzimidazol-l -yl]-3-(l -hydroxyethyl)-2-pyri dyl]-5-methyl- pyrazole-3 -carbonitrile (43.2 mg, 0.090 mmol, 28.7% yield) as white solid. LC-MS: m/z = 478.2 [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, DMSO-t/ ₆ ) 6 = 9.05 (s, 1H), 8.48 (d, J = 8.6 Hz, 1H), 8.27 (d, J = 8.4 Hz, 1H), 8.14 (s, 1H), 7.76 (d, J = 8.3 Hz, 1H), 7.32 (dd, J = 1.4, 8.3 Hz, 1H), 7.10 (d, J= 0.6 Hz, 1H), 5.55 (d, J = 4.4 Hz, 1H), 4.64 - 4.55 (m, 1H), 4.20 (s, 2H), 3.25 - 3.18 (m, 2H), 3.06 (t, J= 6.7 Hz, 2H), 2.37 (s, 3H), 2.22 - 2.09 (m, 2H), 1.27 (d, J= 6.5 Hz, 3H).

Example 203

3- [3-(l-Hydroxyethyl)-6- [5- [(6-methylpyridazin-3-yl)amino] benzimidazol-l-yl]-2-pyridyl]- 2-methoxy-phenol; formic acid

Step 1 : l-[ 2-(3-hydroxy-2-methoxy-phenyl)-6-[5-[ ( 6-methylpyridazin-3-yl)amino ]benzimidazol- 1-yl ]-3-pyridyl ethanone Prepared in analogy to example 143, step 2 using l-[2-chloro-6-[5-[(6-methylpyridazin-3- yl)amino]benzimidazol-l-yl]-3-pyridyl]ethanone (80.0 mg, 0.210 mmol, 1.0 equiv., prepared in example 76, step 2), and 2-methoxy-3-(4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2-yl)phe nol (316.9 mg, 1.27 mmol, 6 equiv.), to afford l-[2-(3-hydroxy-2-methoxy-phenyl)-6-[5-[(6- methylpyridazin-3-yl)amino]benzimidazol-l-yl]-3-pyridyl]etha none (20 mg, 0.040 mmol, 20.3% yield) as a yellow solid. LC-MS: m/z = 467.3, [M+H] ⁺ , ESI pos.

Step 2:3-[ 3-( 1 -hydroxyethyl)-6-[5-[ ( 6-methylpyridazin-3-yl)amino ]benzimidazol-l-yl -2- pyridyl / -2-methoxy-phenol; formic acid

Prepared in analogy to example 53, step 4 using l-[2-(3-hydroxy-2-methoxy-phenyl)-6-[5-[(6- methylpyridazin-3-yl)amino]benzimidazol-l-yl]-3-pyridyl]etha none (20.0 mg, 0.040 mmol, 1.0 equiv) to afford 3-[3-(l-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino]be nzimidazol-l-yl]- 2-pyridyl]-2-methoxy-phenol; formic acid (3 mg, 0.010 mmol, 12.2% yield) as a yellow solid.

LC-MS: m/z = 469.2, [M+H] ⁺ , ESI pos.

Example 204

3- [3-(l-Hydroxyethyl)-6- [5- [(6-methylpyridazin-3-yl)amino] benzimidazol- 1-yl] -2- pyridyl]furan-2-carbonitrile

Step 1 : 3-[ 3-acetyl-6-[5-[ ( 6-methylpyridazin-3-yl)amino ]benzimidazol-l-yl / -2 -pyridyl ]furan-2- carbonitrile Prepared in analogy to example 143, step 2 using l-[2-chloro-6-[5-[(6-methylpyridazin-3- yl)amino]benzimidazol-l-yl]-3-pyridyl]ethanone (50.0 mg, 0.130 mmol, 1.0 equiv., prepared in example 65, step 1) and (2-cyano-3 -furyl )boronic acid (35.6 mg, 0.260 mmol, 2.0 equiv.) to afford 3-[3-acetyl-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol -l-yl]-2-pyridyl]furan-2- carbonitrile (12 mg, 0.030 mmol, 20.9% yield) as yellow solid. LC-MS: m/z = 436.1 [M+H] ⁺ , ESI pos.

Step 2: 3-[ 3-( I -hydroxyethyl)-6-[5-[ ( 6-methylpyridazin-3-yl)amino ]benzimidazol-l-yl -2- pyridyl furan-2 -carbonitrile

Prepared in analogy to example 53, step 4 using 3-[3-acetyl-6-[5-[(6-methylpyridazin-3- yl)amino]benzimidazol-l-yl]-2-pyridyl]furan-2-carbonitrile (10.0 mg, 0.020 mmol, 1.0 equiv.) and NaBEU (4.37 mg, 0.110 mmol, 5. Equiv.) to afford 3-[3-(l-hydroxyethyl)-6-[5-[(6- methylpyridazin-3-yl)amino]benzimidazol-l-yl]-2-pyridyl]fura n-2-carbonitrile (3.3 mg, 0.010 mmol, 32.3% yield) as white solid. LC-MS: m/z = 438.1 [M+H] ⁺ , ESI pos. 'HNMR (400 MHz, CD ₃ OD) 5 = 8.95 (s, 1H), 8.38 (d, J= 8.8 Hz, 1H), 8.27 - 8.17 (m, 2H), 8.06 - 7.95 (m, 2H), 7.68 - 7.58 (m, 1H), 7.35 (d, J= 9.2 Hz, 1H), 7.18 - 7.09 (m, 2H), 5.24 - 5.11 (m, 1H), 2.53 (s, 3H), 1.53 (d, J = 6.4 Hz, 3H).

Example 205

1- [3-(l-Hydroxyethyl)-6- [5- [(6-methylpyridazin-3-yl)amino] benzimidazol-l-yl]-2-pyridyl]- 4,5,6,7-tetrahydropyrazolo [4,3-c] pyridine-3-carbonitrile

Step 1: 5-tert-butyl 3-ethyl 6, 7-dihydro-lH-pyrazolo[4,3-c]pyridine-3,5(4H)-dicarboxylate

Di-tert.-butyl-dicarbonate (1.04 g, 4.76 mmol, 1.0 equiv.) was added to an ice-cold suspension of ethyl 4,5,6,7-tetrahydro-lH-pyrazolo[4,3-c]pyridine-3-carboxylate (930 mg, 4.76 mmol, 1.0 equiv.) in Et2O (45 ml) . After the addtion the reaction mixture was stirred at RT overnight. Water was added and the mixture was extracted with EtOAc. The organic layers were washed with water and brine, dried over Na2SO4 and evaporated. The crude was purified by flash column chromatography (silica gel, 30-55% EtOAc in heptane) to yield the title compound (1.08 g, 76.7% yield) as white solid. LC-MS: m/z = 396.0 [M+H] ⁺ , 240.2 [M-Boc+H] ⁺ .

Step 2: 5-tert-butoxycarbonyl-l ,4, 6, 7-tetrahydropyrazolo [4, 3-c] pyridine-3-carboxylic acid

To a stirred, almost clear solution 5-tert-butyl 3-ethyl 6,7-dihydro-lH-pyrazolo[4,3-c]pyridine- 3,5(4H)-dicarboxylate (1.25 g, 4.23 mmol, 1.0 equiv.) at RT in a mixture of methanol (6.5 mL) and tetrahydrofuran (6.5 mL) under an argon atmosphere was added 1 M NaOH (12.7 mL, 12.7 mmol, 3.0 equiv.). Stirring was continued overnight. The mixture was treated with IN HC1 (12.2 ml) and diluted with H2O (25 ml), and the reaction mixture was stirred at RT for another lh30, yielding a suspension. The product was collected by filtration, washed throughly with H2O and dried under reduced pressure to yield 5-tert-butoxycarbonyl-l,4,6,7-tetrahydropyrazolo[4,3- c]pyridine-3 -carboxylic acid (997 mg, 86.4% yield) as off-white solid. LC-MS: m/z = 266.2 [M-H]-, ESI neg.

Step 3: 3 -carbamoyl- 1,4, 6, 7-tetrahydropyrazolo [4, 3-c] pyridine-5-carboxylic acid tert-butyl ester

To a stirred solution of 5-tert-butoxycarbonyl-l,4,6,7-tetrahydropyrazolo[4,3-c]pyrid ine-3- carboxylic acid (955 mg, 3.22 mmol, 1.0 equiv.) at RT in DMF (15 mL) under an argon atmosphere was added CDI (677.86 mg, 4.18 mmol, 1.3 equiv.). After stirring for 3 hours at RT, NH4OH (2.25 g, 2.5 mL, 64.31 mmol, 20 equiv.) was added and stirring was continued for 6 hours. H2O was added yielding an off-white slurry which was was stirred at RT overnight. The solid was collected by filtration, washed thoroughly with H2O and dried to yield 3 -carbarn oyl- l,4,6,7-tetrahydropyrazolo[4,3-c]pyridine-5-carboxylic acid tert-butyl ester (775 mg, 88.7% yield) as a white solid. LC-MS: m/z = 265.2 [M H] , ESI neg.

Step 4: 3-cyano-l,4,6, 7-tetrahydropyrazolo[4,3-c]pyridine-5-carboxylic acid tert-butyl ester

A suspension of 3-carbamoyl-l,4,6,7-tetrahydropyrazolo[4,3-c]pyridine-5-carb oxylic acid tertbutyl ester (770 mg, 2.75 mmol, 1.0 equiv.) and EtsN (833.9 mg, 1.15 mL, 8.24 mmol, 3.0 equiv. ) in DCM (20 mL) under an argon atmosphere was cooled to 0 °C and TFAA (1.73 g, 1.16 mL, 8.24 mmol, 3 equiv.) was slowly. The reaction nmixture was allowed to stir at 0 °C for 1 h. The reaction mixture was adsorbed onto silica gel and purified by flash column chromatography (silica gel, 0-15% MeOH in DCM). The resulting light brown paste was suspended in Et2O and stirred at RT overnight. The solid was collected by filtration, washed with Et2O and dried to yield the title compound (490 mg, 68.3% yield) as a white solid. LC-MS: m/z = 247.2 [M H] , ESI neg.

Step 5: l-(3-acetyl-6-chloro-2-pyridyl)-3-cyano-6, 7-dihydro-4H-pyrazolo [4,3-c]pyridine-5- carboxylic acid tert-butyl ester

Prepared in analogy to example 62, step 1 using 3-cyano-l,4,6,7-tetrahydropyrazolo[4,3- c]pyridine-5-carboxylic acid tert-butyl ester (480 mg, 1.84 mmol, 1.0 equiv.) and l-(6-chloro-2- fluoro-3-pyridyl)ethanone (318.78 mg, 1.84 mmol, 1.0 equiv.) to afford the title compound (550 mg, 70.8% yield) as white foam. LC-MS: m/z = 402.1 [M+H] ⁺ , ESI pos.

Step 6: l-[ 3-acetyl-6-[5-[ ( 6-methylpyridazin-3-yl)amino ]benzimidazol-l-yl / -2 -pyridyl ]-3- cyano-6, 7-dihydro-4H-pyrazolo [4,3-c] pyridine-5-carboxylic acid tert-butyl ester and l-[3- acetyl-6-[ 6-[ ( 6-methylpyridazin-3-yl)amino ]benzimidazol-l-yl / -2 -pyridyl / -3-cyano-6, 7-dihydro- 4H-pyrazolo [4, 3-c] pyridine-5-carboxylic acid tert-butyl ester To a stirred solution of l-(3-acetyl-6-chloro-2-pyridyl)-3-cyano-6,7-dihydro-4H-pyraz olo[4,3- c]pyridine-5-carboxylic acid tert-butyl ester (700 mg, 1.74 mmol, 1.0 eqiuv.) at RT in DMSO (7 mL) under an argon atmosphere were added lH-benzimidazol-5-yl-(6-methylpyridazin-3- yl)amine (435.97 mg, 1.74 mmol, 1 equiv., prepared in example 64, intermediate 1) and DABCO (397.79 mg, 393.85 pL, 2.61 mmol, 1.5 equiv.). The mixture was heated to 85 °C and stirring at that temperature was continued for 5 h.The mixture was allowed to cool to RT, diluted with EtOAc and washed with H2O. The aqueous layer was back-extracted with EtOAc. The combined organic layerss were washed with H2O and brine, dried over MgSO4 and the volatiles removed. The residue was purified by flash column chromatography (silica gel, 0-15% MeOH) twice to separate both regioisomers to yield l-[3-acetyl-6-[5-[(6-methylpyridazin-3- yl)amino]benzimidazol-l-yl]-2-pyridyl]-3-cyano-6,7-dihydro-4 H-pyrazolo[4,3-c]pyridine-5- carboxylic acid tert-butyl ester (213 mg, 20.3% yield) as light brown solid and l-[3-acetyl-6-[6- [(6-methylpyridazin-3-yl)amino]benzimidazol-l-yl]-2-pyridyl] -3-cyano-6,7-dihydro-4H- pyrazolo[4,3-c]pyridine-5-carboxylic acid tert-butyl ester (250 mg, 23.8% yield) as a light brown solid. Regioisomer 1 : LC-MS: m/z = 591.3 [M+H] ⁺ , ESI pos. 1H NMR (600 MHz, DMSO-t/ ₆ ) 8 ppm 9.26 (s, 1 H), 9.05 (s, 1 H), 8.46 (s, 1 H), 8.45 (s, 1 H), 8.19 - 8.23 (m, 1 H), 8.10 (d, J= 8.7 Hz, 1 H), 7.51 (br s, 1 H), 7.34 (d, J = 9.1 Hz, 1 H), 7.09 (d, J = 9.1 Hz, 1 H), 4.59 (s, 2 H), 3.68 (t, J= 5.7 Hz, 2 H), 3.10 (br t, J= 5.5 Hz, 2 H), 2.48 (s, 3 H), 2.27 (s, 3 H), 1.37 - 1.55 (m, 9 H). Regioisomer 2: LC-MS: m/z = 591.3 [M+H] ⁺ , ESI pos. 'H NMR (600 MHz, DMSO-t/ ₆ ) 6 ppm 9.32 (s, 1 H), 9.25 (d, J = 1.7 Hz, 1 H), 8.93 (s, 1 H), 8.47 (d, J = 8.4 Hz, 1 H), 8.15 (d, J = 8.4 Hz, 1 H), 7.70 (d, J = 8.7 Hz, 1 H), 7.39 (dd, J = 8.8, 2.1 Hz, 1 H), 7.30 (br d, J= 8.8 Hz, 1 H), 7.05 (d, J= 9.0 Hz, 1 H), 4.52 (s, 2 H), 3.46 (t, J= 5.7 Hz, 2 H), 3.02 - 3.20 (m, 2 H), 2.46 (s, 3 H), 2.28 (s, 3 H), 1.20 - 1.42 (m, 9 H)

Step 7: 3-cyano-l-[ 3-(l -hydroxyethyl)-6-[5-[ ( 6-methylpyridazin-3-yl)amino ]benzimidazol-l-yl ]- 2-pyridyl] -6, 7-dihydro-4H-pyrazolo [4, 3-c] pyridine-5 -carboxylic acid tert-butyl ester

Prepared in analogy to example 53, step 4 using l-[3-acetyl-6-[5-[(6-methylpyridazin-3- yl)amino]benzimidazol-l-yl]-2-pyridyl]-3-cyano-6,7-dihydro-4 H-pyrazolo[4,3-c]pyridine-5- carboxylic acid tert-butyl ester (53 mg, 0.088 mmol, 1.0 equiv.) in MeOH/THF (1 : 1) to afford the title compound (44 mg, 80.2% yield) as light brown solid. LC-MS: m/z = 593.3 [M+H] ⁺ , ESI pos.

Step 8: l-[3-(l -hydroxyethyl)-6-[5-[ ( 6-methylpyridazin-3-yl)amino ]benzimidazol-l-yl ]-2- pyridyl -4, 5, 6, 7-tetrahydropyrazolo[ 4, 3-c ]pyridine-3-carbonitrile

To a stirred light brown solution of 3-cyano-l-[3-(l-hydroxyethyl)-6-[5-[(6-methylpyridazin-3- yl)amino]benzimidazol-l-yl]-2-pyridyl]-6,7-dihydro-4H-pyrazo lo[4,3-c]pyridine-5-carboxylic acid tert-butyl ester (41 mg, 0.066 mmol, 1.0 equiv.) at RT in 1,4-dioxane (1.7 mL) under an argon atmosphere was added 4 M HC1 in dioxane (394.3 mg, 329 pL, 1.31 mmol, 20 equiv.), and stirring at r.t. was continued for lh45. The mixture was concentrated to dryness and purified by (Phenomenex Gemini NX C18 (100mm x 30mm x 5pm). Flow rate: 30 mL / min. Gradient: 15% to 45% CH ₃ CN in (0.1% TEA in H2O) (8 min) then 100% CH ₃ CN (2 min), to yield the title compound (22 mg, 66.6% yield) as off-white solid. LC-MS: m/z = 493.3 [M+H] ⁺ , ESI pos.

Example 206 l-[6-[5-[[6-[2-(l,l-Diketo-l,4-thiazinan-4-yl)ethoxy]pyridaz in-3-yl]amino]benzimidazol-l- yl]-3-(l-hydroxyethyl)-2-pyridyl]-5-methyl-pyrazole-3-carbon itrile Step 1: 4-[2-(6-chloropyridazm-3-yl)oxyethyl] -1 ,4-thiazinane 1,1 -dioxide

Prepared in analogy to example 193, step 1 using 4-(2-hydroxy ethyl )thiomorpholine 1,1 -di oxide (1.2 g, 6.7 mmol, 1.0 equiv.) and 3,6-dichloropyridazine (1.0 g, 6.7 mmol, 1.0 equiv.) to yield 4- [2-(6-chloropyridazin-3-yl)oxyethyl]-l,4-thiazinane 1,1-dioxide (400 mg, 1.37 mmol, 20.4% yield) as off-white solid. LC-MS: m/z = 292.0 [M+H] ⁺ , ESI pos.

Step 2: tert-butyl N-[6-[2-(l, 1-dioxo-l, 4-thiazinan-4-yl)ethoxy]pyridazin-3-yl]carbamate

Prepared in analogy to example 193, step 2 using 4-[2-(6-chloropyridazin-3-yl)oxyethyl]-l,4- thiazinane 1,1-dioxide (330.0 mg, 1.13 mmol, 1.0 equiv.) and tert-butyl carbamate (265.02 mg, 2.26 mmol, 2 equiv.), CS2CO3 (737.07 mg, 2.26 mmol, 2 equiv.) to provide tert-butyl N-[6-[2- (l,l-dioxo-l,4-thiazinan-4-yl)ethoxy]pyridazin-3-yl]carbamat e (300 mg, 0.810 mmol, 71.2% yield) as off-white solid. LC-MS: m/z = 373.1 [M+H] ⁺ , ESI pos.

Step 3: 6-[2-(l, 1-dioxo-l, 4-thiazinan-4-yl)ethoxy]pyridazin-3-amine

Prepared in analogy to example 193, step 3 using tert-butyl N-[6-[2-(l, 1-dioxo-l, 4-thiazinan-4- yl)ethoxy]pyridazin-3-yl] carbamate (300.0 mg, 0.810 mmol, 1.0 equiv.) in DCM (6 mL) were added trifluoroacetic acid (3.0 mL, 38.94 mmol, 48.34 equiv.) to afford 6-[2-(l, 1-dioxo-l, 4- thiazinan-4-yl)ethoxy]pyridazin-3-amine (161 mg, 0.590 mmol, 73.4% yield) as white solid. LC- MS: m/z = 273.0 [M+H] ⁺ , ESI pos.

Step 4: l-[3-acetyl-6-[5-[[6-[2-(l,l-diketo-l,4-thiazinan-4-yl)ethox y]pyridazin-3- yl amino ]benzimidazol-l-yl / -2 -pyridyl ]-5-methyl-pyrazole-3-carbonitrile

Prepared in analogy to example 104, step 2 using l-[3-acetyl-6-(5-bromobenzimidazol-l-yl)-2- pyridyl]-5-methyl-pyrazole-3-carbonitrile (30 mg, 0.071 mmol, 1.0 equiv., prepared in example 65, step 1) and[6-[2-(l,l-diketo-l,4-thiazinan-4-yl)ethoxy]pyridazin-3-y l]amine (38.79 mg, 0.142 mmol, 2.0 equiv. )to afford the title compound (21.2 mg, 46.2% yield) as yellow solid. LC- MS: m/z = 613.3 [M+H] ⁺ , ESI pos.

Step 5: l-[ 6-[5-[[ 6-[ 2-( 1, 1 -diketo- 1, 4-thiazinan-4-yl)ethoxy ]pyridazin-3- yl amino ]benzimidazol-l-yl ]-3-( 1 -hydroxyethyl) -2 -pyridyl ]-5-methyl-pyrazole-3-carbonitrile Prepared in analogy to example 53, step 4 using l-[3-acetyl-6-[5-[[6-[2-(l, l-diketo-1,4- thiazinan-4-yl)ethoxy]pyridazin-3-yl]amino]benzimidazol-l-yl ]-2-pyridyl]-5-methyl-pyrazole-3- carbonitrile (21.2 mg, 0.033 mmol, 1.0 equiv.) on MeOH/THF (1:1) to afford the title compound (11.1 mg, 53.3% yield). LC-MS: m/z = 615.3 [M+H] ⁺ , ESI pos.

Example 207 1- [3-(l-Hydroxyethyl)-6- [5- [ [6-(oxetan-3-yloxy)pyridazin-3-yl] amino] benzimidazol- 1-yl] -2- pyridyl]-5-methyl-pyrazole-3-carbonitrile

Step 1: 3-chloro-6-(oxetan-3-yloxy)pyridazine

Prepared in analogy to example 93, step 1 using oxetan-3-ol (493.8 mg, 6.7 mmol, 1.0 equiv.) and 3,6-dichloropyridazine (1.0 g, 6.7 mmol, 1.0 equiv.) to afford 3-chloro-6-(oxetan-3- yloxy)pyridazine (1.0 g, 5.36 mmol, 79.8% yield) as off-white solid. LC-MS: m/z = 187.0 [M+H] ⁺ , ESI pos.

Step 2: tert-butyl N-[6-(oxetan-3-yloxy)pyridazin-3-yl] carbamate Prepared in analogy to example 193, step 2 using 3 -chi oro-6-(ox etan-3 -yloxy)pyridazine (1.0 g, 5.36 mmol, 1.0 equiv.) and tert-butyl carbamate (1.26 g, 10.72 mmol, 2.0 equiv.). LC-MS: m/z = 268.0 [M+H] ⁺ , ESI pos.

Step 3: 6-(oxetan-3-yloxy)pyridazin-3-amine Prepared in analogy to example 193, step 3 using tert-butyl N-[6-(ox etan-3 -yloxy)pyridazin-3 - yl]carbamate (400.0 mg, 1.5 mmol, 1.0 equiv.) to provide 6-(ox etan-3 -yloxy)pyridazin-3 -amine (102 mg, 0.610 mmol, 36.7% yield) as white solid. .). LC-MS: m/z = 168.0 [M+H] ⁺ , ESI pos. Step 4: l-[3-acetyl-6-[5-[[ 6-(oxetan-3-yloxy)pyridazin-3-yl]amino]benzimidazol-l-yl]-2- pyridyl]-5-methyl-pyrazole-3-carbonitrile

Prepared in analogy to example 104, step 2 using l-[3-acetyl-6-(5-bromobenzimidazol-l-yl)-2- pyridyl]-5-methyl-pyrazole-3-carbonitrile (30 mg, 0.071 mmol, 1.0 equiv., prepared in example 65, step 1) and [6-(oxetan-3-yloxy)pyridazin-3-yl]amine (23.81 mg, 0.142 mmol, 2 equiv.) to afford the title compound (23.7 mg, 62.3% yield) as a yellow solid. LC-MS: m/z = 508.3 [M+H] ⁺ , ESI pos.

Step 5: l-[ 3-( 1 -hydroxyethyl)-6-[5-[[ 6-(oxetan-3-yloxy)pyridazin-3-yl amino Jbenzimidazol-1- y I] -2 -pyridyl ]-5-methyl-pyrazole-3-carbonitrile

Prepared in analogy to example 53, step 4 using l-[3-acetyl-6-[5-[[6-(oxetan-3-yloxy)pyridazin- 3-yl]amino]benzimidazol-l-yl]-2-pyridyl]-5-methyl-pyrazole-3 -carbonitrile (23.7 mg, 0.047 mmol, 1.0 equiv.) in MeOH/THF (1:1) to afford the title compound (14.3 mg, 57.1% yield) as light yellow solid. LC-MS: m/z = 510.3 [M+H] ⁺ , ESI pos.

Example 208

1- [6- [5- [(6-Methylpyridazin-3-yl)amino] benzimidazol- 1-yl] -2- [(3S)-pyrrolidin-3-yl] oxy-3- pyridyl] ethanol

Step 1: 6-chloro-2-hydroxy-nicotinic acid methyl ester

Under an argon atmosphere was dissolved 6-chloro-2-hydroxy-nicotinic acid (1.0 g, 5.76 mmol, 1.0 equiv.) in DCM (15 mL) and cooled to 0 °C before SOCh (2.06 g, 1.25 mL, 17.29 mmol, 3.0 equiv.) was added. After 5 min at 0 °C, the ice bath was removed and the reaction was stirred for 1.5 h at RT. MeOH (184.6 mg, 233 pL, 5.76 mmol, 1.0 equiv.) was added and the reaction was stirred for 30 min. The reaction mixture was concentrated in vacuo and purified by flash column chromatography (silica gel, 0 - 100% EtOAc in heptane) to obtain 6-chloro-2-hydroxy-nicotinic acid methyl ester (710 mg, 65%) as off-white solid. LC-MS: m/z = 188.02 [M+H] ⁺ , ESI pos.

Step 2: 2-[(3S)-l-tert-butoxycarbonylpyrrolidin-3-yl]oxy-6-chloro-ni cotinic acid methyl ester

Under an argon atmosphere were added 6-chloro-2-hydroxy-nicotinic acid methyl ester (150 mg, 0.800 mmol, 1 equiv.), (3R)-3 -hydroxypyrrolidine- 1 -carboxylic acid tert-butyl ester (179.7 mg, 0.960 mmol, 1.2 equiv.) and PPhs (251.7 mg, 0.960 mmol, 1.2 equiv.). The compounds were dissolved in THF (3 mL). DIAD (198 mg, 190 pL, 0.960 mmol, 1.2 equiv.) was added. After 1 h stirring at RT, another portion of (3R)-3 -hydroxypyrrolidine- 1 -carboxylic acid tert-butyl ester (179.7 mg, 0.960 mmol, 1.2 equiv.), PPhs (251.7 mg, 0.960 mmol, 1.2 equiv.) and DIAD (198 mg, 190 pL, 0.960 mmol, 1.2 equiv.) were added, and the mixture stirred for another h. The mixture was diluted with water and extracted with EtOAc. The organic layers were combined, dried over MgSCh and concentrated under reduced pressure. The crude was purified by flash column chromatography (silica gel, 0 - 100% EtOAc in heptane) to obtain the title compound 2- [(35)-l-tert-butoxycarbonylpyrrolidin-3-yl]oxy-6-chloro-nico tinic acid methyl ester (247.6 mg, 86.3%) as light brown solid. LC-MS: m/z = 301.04 [M-'Bu+H] , ESI pos.

Step 3: 2-[(3S)-l-tert-butoxycarbonylpyrrolidin-3-yl]oxy-6-chloro-ni cotinic acid

To a stirred suspension of 6-chloro-2-[(35)-l-tert-butoxycarbonylpyrrolidin-3-yl]oxy-ni cotinic acid methyl ester (240 mg, 0.673 mmol, 1.0 equiv.) in a mixture of MeOH (3.2 mL), THF (3.2 mL) and water (5.2 mL) was added under an argon atmosphere and at RT 1 M NaOH (1.35 mL, 1.35 mmol, 2 eq). Stirring at RT was continued overnight. The mixture was heated to 65 °C and stirring was continued for 6 hours. The mixture was cooled to 0 °C before IN HC1 (1.35 ml) was added. The mixture was diluted with water and extracted with EtOAc. The combined organic layers were dried over MgSCU and the volatiles evaporated to yield 2-[(35)-l-tert- butoxycarbonylpyrrolidin-3-yl]oxy-6-chloro-nicotinic acid as off-white solid which was used in the next step without further purification. LC-MS: m/z = 341.21 [M-H]", ESI neg.

Step 4: ( 3S)-3-[ [ 6-chloro-3-[ methoxy(methyl)carbamoyl ]-2-pyridyl J oxy ]pyrrolidine-l- carboxylic acid tert-butyl ester

To a stirred solution of 6-chloro-2-[(35)-l-tert-butoxycarbonylpyrrolidin-3-yl]oxy-ni cotinic acid (used as crude from the previous step) at RT in DMF (2 mL) under an argon atmosphere were added HATU (221.0 mg, 0.581 mmol, 1.2 equiv.) and DIPEA (187.8 mg, 248.7 pL, 1.45 mmol, 3.0 equiv.). After stirring for 5 minutes, N,O-dimethylhydroxylamine hydrochloride (56.7 mg, 0.581 mmol, 1.2 equiv.) was added and the mixture was stirred at RT for further 90 minutes. The mixture was diluted with H2O upon which a precipitate formed and the yellow suspension was stirred for 1 hour. The solid was then collected by filtration, washed well with H2O and dried under reduced pressure to yield the title compound (153 mg, 81.9% yield). LC-MS: m/z = 286.12 [M-Boc+H] ⁺ , ESI pos.

Step 5: (3 S)-3-[(3-acetyl-6-chloro-2-pyridyl)oxy]pyrrolidine-l -carboxylic acid tert-butyl ester

To a stirred suspension of (35)-3-[[6-chloro-3-[methoxy(methyl)carbamoyl]-2- pyridyl]oxy]pyrrolidine-l-carboxylic acid tert-butyl ester (130 mg, 0.337 mmol, 1.0 equiv.) at 0 °C in THF (3.25 mL) under an argon atmosphere was added MeMgBr (3.2 M in 2-MeTHF, 126 pL, 0.40 mmol, 1.2 equiv.). The cooling bath was removed and stirring at RT was continued for 15 minutes. Another portion ofMeMgBr (3.2 M in 2-MeTHF, 126 pL, 0.40 mmol, 1.2 equiv.) was added and stirring at RT was continued overnight. The mixture was treated carefully with H2O extracted with EtOAc. The combined organic laerss were washed with water and brine, dried over MgSC and concentrated to obtain crude (35)-3-[(3-acetyl-6-chloro-2- pyridyl)oxy]pyrrolidine-l -carboxylic acid tert-butyl ester as brown solid which was used in the next step without further purification. LC-MS: m/z = 285.10 [M-tBu+H] ⁺ , ESI pos.

Step 6: ( 3S)-3-[ [ 3-acetyl-6-[5-[ ( 6-methylpyridazin-3-yl)amino ]benzimidazol-l-yl ]-2- pyridyl] oxy] pyrrolidine- 1 -carboxylic acid tert-butyl ester and (3S)-3-[[3-acetyl-6-[6-[(6- methylpyridazin-3-yl)amino ]benzimidazol-l-yl / -2 -pyridyl oxy ] pyrrolidine- 1 -carboxylic acid tert-butyl ester

Prepared in analogy to Example 64, step 2 using (35)-3-[(3-acetyl-6-chloro-2- pyridyl)oxy]pyrrolidine-l -carboxylic acid tert-butyl ester (used as crude from the previous step), lH-benzimidazol-5-yl-(6-methylpyridazin-3-yl)amine (87.24 mg, 0.387 mmol, 1.0 equiv., example 64, intermediate 1) and K2CO3 (160.6 mg, 1.16 mmol, 3.0 equiv.) to yield (3S)-3-[[3- acetyl-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-l-yl ]-2-pyridyl]oxy]pyrrolidine-l- carboxylic acid tert-butyl ester as an off-white solid (70 mg, 34.1% yield) and (3S)-3-[[3-acetyl- 6-[6-[(6-methylpyridazin-3-yl)amino]benzimidazol-l-yl]-2-pyr idyl]oxy]pyrrolidine-l -carboxylic acid tert-butyl ester as an off-white solid (42 mg, 20.3% yield). LC-MS: m/z = 423.2 [M+H] ⁺ , ESI pos. Regioisomer 1 : 1H NMR (600 MHz, DMSO-t/ ₆ ) 8 ppm 9.27 (s, 1 H), 9.05 (s, 1 H), 8.35 (br d, J= 3.9 Hz, 1 H), 8.30 (br d, J= 8.2 Hz, 1 H), 8.23 (br dd, J= 8.6, 5.7 Hz, 1 H), 7.63 - 7.69 (m, 2 H), 7.36 (d, J = 9.1 Hz, 1 H), 7.11 (d, J = 9.1 Hz, 1 H), 5.79 - 5.94 (m, 1 H), 3.62 - 3.78 (m, 2 H), 3.53 (br s, 2 H), 2.56 (s, 3 H), 2.31 (br d, J= 1.1 Hz, 2 H), 1.40 (br d, J= 18.4 Hz, 9 H). Regioisomer 2: 1H NMR (600 MHz, DMSO-t/ ₆ ) 6 ppm 9.54 (br s, 1 H), 9.35 (s, 1 H), 8.96 (s, 1 H), 8.23 - 8.45 (m, 1 H), 7.62 - 7.79 (m, 2 H), 7.37 (d, J= 9.1 Hz, 1 H), 7.20 (br d, J= 8.6 Hz, 1 H), 7.12 (s, 1 H), 6.03 - 6.35 (m, 1 H), 3.65 - 3.97 (m, 1 H), 3.51 - 3.67 (m, 1 H), 2.58 (s, 3H), 2.15 - 2.38 (m, 2 H), 1.36 (br d, J= 17.3 Hz, 9 H).

Step 7: ( 3S)-3-[ [3-(l -hydroxyethyl)-6-[5-[ ( 6-methylpyridazin-3-yl)amino ]benzimidazol-l-yl ]-2- pyridyl] oxy] pyrrolidine- 1 -carboxylic acid tert-butyl ester

Prepared in analogy to example 53, step 4, using (35)-3-[[3-acetyl-6-[5-[(6-methylpyridazin-3- yl)amino]benzimidazol-l-yl]-2-pyridyl]oxy]pyrrolidine-l-carb oxylic acid tert-butyl ester (42.7 mg, 0.081 mmol, 1.0 equiv.) in THF/iPrOH (1 : 1) to yield (3S)-3-[[3-(l-hydroxyethyl)-6-[5-[(6- methylpyridazin-3-yl)amino]benzimidazol-l-yl]-2-pyridyl]oxy] pyrrolidine-l-carboxylic acid tert-butyl ester (29.9 mg, 69.8%) as white solid. LC-MS: m/z = 532.22 [M+H] ⁺ , ESI pos.

Step 8: l-[ 6-[5-[ ( 6-methylpyridazin-3-yl)amino ]benzimidazol-l-yl ]-2-[ ( 3S)-pyrrolidin-3-yl ]oxy- 3-pyridyl ethanol

(35)-3-[[3-(l-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl )amino]benzimidazol-l-yl]-2- pyridyl]oxy]pyrrolidine-l-carboxylic acid tert-butyl ester (29.9 mg, 0.056 mmol, 1.0 equiv.) was dissolved in DCM (0.6 mL). At 0 °C TFA (128.3 mg, 86.7 pL, 1.12 mmol, 20.0 equiv.) was added. The ice bath was removed and the reaction was stirred at RT for 2 hours. The mixture was concentrated in vacuo and purified by reversed phase column chromatography (silica gel C18, 10 - 100% CH3CN in H2O) to obtain the title compound l-[6-[5-[(6-methylpyridazin-3- yl)amino]benzimidazol-l-yl]-2-[(35)-pyrrolidin-3-yl]oxy-3-py ridyl]ethanol (9.7 mg, 40.0%) as off-white solid. LC-MS: m/z = 432.27 [M+H] ⁺ , ESI pos. Example 212 l-[3-(l-Hydroxyethyl)-6-[6-[(2-oxopyrrolidin-l-yl)methyl]ben zimidazol-l-yl]-2-pyridyl]-5- methyl-pyrazole-3-carbonitrile

Step 1: methyl l-(2-trimethylsilylethoxymethyl)benzimidazole-5-carboxylate

To a solution of methyl lH-benzimidazole-5-carboxylate (3.0 g, 17.03 mmol, 1.0 equiv.) in THF (50 mL) was added sodium hydride (1.02 g, 25.54 mmol, 1.5 equiv.) slowly at 0 °C, and the reaction mixture was stirred at 0 °C for 1 h. 2-(trimethylsilyl)ethoxymethyl chloride (3.92 mL, 22.14 mmol, 1.3 equiv.) was added slowly at 0 °C, the cooling bath was removed and the reaction mixture was stirred at RT for 2 hours. The reaction was poured into water EtOAc. The organic phase was washed with brine, dried with anhydrous Na2SO4, filtered and concentrated to dryness in vacuo. The residue was purified by flash column chromatography (silica gel, 10-50% EtOAc in PE) to afford methyl 1 -(2 -trimethyl silyl ethoxymethyl)benzimidazole-5-carboxylate (3.8 g, 12.4 mmol, 72.8% yield) as light brown oil. LC-MS: m/z = 307.2 [M+H] ⁺ , ESI pos.

Step 2: [ l-(2-trimethylsilylethoxymethyl)benzimidazol-5-yl] methanol

To a solution of methyl 1 -(2 -trimethyl silyl ethoxymethyl)benzimidazole-5-carboxylate (6.5 g, 21.2 mmol, 1.0 equiv.) in THF (65 mL) was added LiAlEL (1.28 g, 32.1 mmol, 1.5 equiv.) in portions at -10 °C. The reaction mixture was stirred at -10 °C for 1.5 h. After the completion of the reaction, it was added dropwise water (0.53 mL) at -15 °C under stirring, followed by NaOH (15%, 0.53 mL). The mixture was filtered, the mother liquor was concentrated under reduced pressure. The residue was purified by flash column chromatography (silica gel, 70% EtOAc in PE) to give [1 -(2 -trimethylsilyl ethoxymethyl)benzimidazol-5-yl]methanol (5.0 g, 18.0 mmol, 84.7% yield) as yellow oil. LC-MS: m/z = 279.2 [M+H] ⁺ , ESI pos.

Step 3: 2-[[5-(chloromethyl)benzimidazol-l-yl] methoxy] ethyl-trimethyl-silane

To the solution of [1 -(2 -trimethyl silyl ethoxymethyl)benzimidazol-5-yl]methanol (2.5 g, 9.0 mmol, 1.0 equiv.) and DIPEA (4.68 mL, 27.0 mmol, 3.0 equiv.) in DCM (40 mL) was added MsCl (1.39 mL, 18.0 mmol, 2.0 equiv.) dropwise at 0 °C. The reaction mixture was stirred at RT for 12 hours. The reaction mixture was poured into aqueous NaHCCh under stirring and was extracted with DCM. The combined extracts were concentrated under vacuum and purified by flash column chromatography (silica gel, 40% EtOAc in PE) to yield 2-[[5- (chloromethyl)benzimidazol-l-yl]methoxy]ethyl-trimethyl-sila ne (1.7 g, 5.73 mmol, 63.7% yield) as yellow oil. LC-MS: m/z = 297.1 [M+H] ⁺ , ESI pos.

Step 4: l-[[ l-(2-trimethylsilylethoxymethyl)benzimidazol-5-yl] methyl] pyrrolidin-2-one

To a solution of 2-pyrrolidone (0.23 mL, 3.03 mmol, 1.5 equiv.) in DMF (20 mL) was added sodium hydride (162.0 mg, 4.05 mmol, 2.0 equiv.) in portions. The mixture was stirred at 0 °C for 30 min. Then 2-[[5-(chloromethyl)benzimidazol-l-yl]methoxy]ethyl-trimethy l-silane (600.0 mg, 2.02 mmol, 1.0 equiv.) was added dropwise as a solution in DMF (2 mL). The reaction mixture was stirred at 20 °C for 1 h. The reaction mixture was poured into aqueous NH4CI solution under stirring and was extracted with EtOAc. The organic phase was washed with brine and the volatiles evaporated. The residue was purified by flash column chromatography (silica gel, 10%MeOH in EtOAc) and concentrated under reduced pressure to give l-[[l-(2- trimethylsilylethoxymethyl)benzimidazol-5-yl]methyl]pyrrolid in-2-one (450 mg, 1.3 mmol, 64.44% yield) as yellow oil. LC-MS: m/z = 346.1 [M+H] ⁺ , ESI pos.

Step 5: l-(lH-benzimidazol-5-ylmethyl)pyrrolidin-2-one

TFA (3 mL) was added to 1-[[1 -(2 -trimethyl silyl ethoxymethyl)benzimidazol-5- yl]methyl]pyrrolidin-2-one (430.0 mg, 1.24 mmol, 1.0 equiv.) at 0 °C, the cooling bath removed and the reaction was further stirred at RT for 2 hours. The mixture was concentrated to yield crude l-(lH-benzimidazol-5-ylmethyl)pyrrolidin-2-one as yellow oil which was used in the next step without further purification. LC-MS: m/z = 216.1 [M+H] ⁺ , ESI pos.

Step 6: l-[ 3-acetyl-6-[ 6-[ (2-oxopyrrolidin-l-yl)methyl ]benzimidazol-l-yl ]-2-pyridyl ]-5-methyl- pyrazole-3-carbonitrile and l-[ 3-acetyl-6-[ 6-[ (2-oxopyrrolidin-l-yl)methyl ]benzimidazol-l-yl /- 2-pyridyl]-5-methyl-pyrazole-3-carbonitrile

Prepared in analogy to example 64, step 2 using l-(3-acetyl-6-chloro-2-pyridyl)-5-methyl- pyrazole-3 -carbonitrile (270.0 mg, 1.04 mmol, 1.0 equiv., prepared in example 64, step 1), 1- (lH-benzimidazol-5-ylmethyl)pyrrolidin-2-one (used as crude from the previous step) and K2CO3 (429.42 mg, 3.11 mmol, 3 equiv.) to yield l-[3-acetyl-6-[5-[(2-oxopyrrolidin-l- yl)methyl]benzimidazol-l-yl]-2-pyridyl]-5-methyl-pyrazole-3- carbonitrile (45 mg, 0.100 mmol, 9.9% yield) as yellow oil and l-[3-acetyl-6-[6-[(2-oxopyrrolidin-l-yl)methyl]benzimidazol- l-yl]- 2-pyridyl]-5-methyl-pyrazole-3-carbonitrile (30 mg, 0.070 mmol, 6.59% yield) as yellow solid after purification and separation of both regioisomers by preparative TLC (10% MeOH in DCM). Regioisomer 1 : LC-MS: m/z = 440.2 [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, CDCI3) 8 = 2.23 (s, 3 H) 2.42 - 2.52 (m, 3 H) 2.63 (s, 3 H) 3.33 (t, J = 7.03 Hz, 2 H) 4.13 (q, J= 7.21 Hz, 2 H) 4.63 (s, 2 H) 6.73 (s, 1 H) 7.34 - 7.40 (m, 1 H) 7.74 - 7.81 (m, 2 H) 7.98 - 8.03 (m, 1 H) 8.31 (d, J = 8.31 Hz, 1 H) 8.65 (s, 1 H). Regioisomer 2: LC-MS: m/z = 440.2 [M+H] ⁺ , ESI pos ^J H NMR (400 MHz, CDCI3) 5 = 1.94 - 1.99 (m, 2 H) 2.23 (s, 3 H) 2.38 - 2.43 (m, 2 H) 2.63 (s, 3 H) 3.28 - 3.33 (m, 3 H) 4.59 - 4.63 (m, 2 H) 6.74 (s, 1 H) 7.31 (d, J= 8.19 Hz, 1 H) 7.77 - 7.82 (m, 1 H) 7.85 (d, J= 8.31 Hz, 1 H) 7.94 - 7.98 (m, 1 H) 8.30 - 8.36 (m, 1 H) 8.64 (s, 1 H).

Step 7: l-[ 3-( 1 -hydroxyethyl)-6-[ 6-[ (2-oxopyrrolidin-l-yl)methyl ]benzimidazol-l-yl ]-2-pyridyl /- 5-methyl-pyrazole-3-carbonitrile

Prepared in analogy to example 53, step 4 using l-[3-acetyl-6-[6-[(2-oxopyrrolidin-l- yl)methyl]benzimidazol-l-yl]-2-pyridyl]-5-methyl-pyrazole-3- carbonitrile (25.0 mg, 0.060 mmol, 1.0 equiv.) and NaBH4 (6.46 mg, 0.170 mmol, 3.0 equiv.) to provide l-[3-(l- hydroxyethyl)-6-[6-[(2-oxopyrrolidin-l-yl)methyl]benzimidazo l-l-yl]-2-pyridyl]-5-methyl- pyrazole-3 -carbonitrile (4.1 mg, 0.010 mmol, 16.3% yield) as colorless oil after preparative HPLC (Phenomenex Synergi C18 150 x 25mm x 10 pm, gradient 29 - 45% CH3CN in H2O (with formic acid) over 8 min, then 100% CH3CN (2 min), flow rate 25 mL/min, 1 injection). LC-MS: m/z = 442.1, [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, CD3OD) 5 = 8.96 (s, 1H), 8.53 (d, J= 8.5 Hz, 1H), 8.17 (d, J= 8.5 Hz, 1H), 8.10 (d, J= 0.9 Hz, 1H), 7.77 (d, J= 8.4 Hz, 1H), 7.34 (dd, J= 1.6, 8.3 Hz, 1H), 6.91 (d, J = 0.8 Hz, 1H), 4.78 (d, J = 6.5 Hz, 1H), 4.62 (d, J= 3.4 Hz, 2H), 3.38 - 3.34 (m, 2H), 2.41 (d, J= 0.6 Hz, 3H), 2.38 (d, J= 8.5 Hz, 2H), 2.00 - 1.92 (m, 2H), 1.43 (d, J = 6.5 Hz, 3H).

Example 213 l-[3-(l-Hydroxyethyl)-6-[5-[(2-oxopyrrolidin-l-yl)methyl]ben zimidazol-l-yl]-2-pyridyl]-5- methyl-pyrazole-3-carbonitrile

Prepared in analogy to example 53, step 4 using l-[3-acetyl-6-[5-[(2-oxopyrrolidin-l- yl)methyl]benzimidazol-l-yl]-2-pyridyl]-5-methyl-pyrazole-3- carbonitrile (45.0 mg, 0.100 mmol, 1.0 equiv., prepared in example 212, step 6) and NaBELj (11.62 mg, 0.310 mmol, 3.0 equiv.) to provide l-[3-(l-hydroxyethyl)-6-[5-[(2-oxopyrrolidin-l-yl)methyl]ben zimidazol-l-yl]- 2-pyridyl]-5-methyl-pyrazole-3-carbonitrile (6 mg, 0.010 mmol, 13.27% yield) as white solid after preparative HPLC (Phenomenex Synergi C18 150 x 25mm x 10 pm, gradient 27 - 45% CH3CN in H2O (with formic acid) over 9 min, then 100% CH3CN (2 min), flow rate 25 mL/min, 1 injection). LC-MS: m/z = 442.1, [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, CD3OD) 5 = 8.97 (s, 1H), 8.54 (d, J = 8.3 Hz, 1H), 8.18 (dd, J= 2.4, 8.4 Hz, 2H), 7.70 (s, 1H), 7.39 - 7.30 (m, 1H), 6.88 (s, 1H), 4.79 (d, J = 6.2 Hz, 1H), 4.63 (s, 2H), 3.40 (t, J= 7.1 Hz, 2H), 2.48 (t, J = 8.0 Hz, 2H), 2.42 (s, 3H), 2.09 - 2.00 (m, 2H), 1.43 (d, J= 6.5 Hz, 3H).

Example 214

1- [2-(3-Methoxy-5-methyl-pyrazol-l-yl)-6- [5- [(6-methylpyridazin-3- yl)amino]benzimidazol-l-yl]-3-pyridyl]ethanol; formic acid

Step 1 : 2-(3-methoxy-5-methyl-pyrazol-l-yl)-6-[5-[ ( 6-methylpyridazin-3-yl)amino ]benzimidazol- 1-yl ]pyridine-3-carboxylic acid To a solution of methyl 2-(3-methoxy-5-methyl-pyrazol-l-yl)-6-[5-[(6-methylpyridazin -3- yl)amino]benzimidazol-l-yl]pyridine-3-carboxylate (200.0 mg, 0.430 mmol, 1.0 equiv., prepared in Example 153, step 2) in THF (10 mL), MeOH (10 mL) and water (10 mL) was added LiOH EEO monohydrate (20.0 mg, 0.480 mmol, 1.12 equiv.). The mixture was stirred at 25 °C for 4 h. The solution was acidified to pH 7 with aqueous HC1 (IN) and concentrated in vacuo to give 2-(3-methoxy-5-methyl-pyrazol-l-yl)-6-[5-[(6-methylpyridazin -3-yl)amino]benzimidazol-l- yl]pyridine-3 -carboxylic acid as light yellow solid. The crude product was used in the next step without further purification. LC-MS: m/z = 457.3 [M+H] ⁺ , ESI pos.

Step 2: N-methoxy-2-(3-methoxy-5-methyl-pyrazol-l-yl)-N-methyl-6-[5- [(6-methylpyridazin-3- yl)amino ]benzimidazol-l-yl ]pyridine-3-carboxamide To a solution of 2-(3-methoxy-5-methyl-pyrazol-l-yl)-6-[5-[(6-methylpyridazin -3- yl)amino]benzimidazol-l-yl]pyridine-3-carboxylic acid (used as crude from the previous step) in DMF (4 mL) were added O,N-dimethylhydroxylamine HCl (42.0 mg, 0.430 mmol, 1.2 equiv.) and DIPEA (0.12 mL, 0.710 mmol, 2.1 equiv.) in this order at 0 °C. Finally HATU (158.0 mg, 0.420 mmol, 1.2 equiv.) was added. The pH was confirmed to be at 5-6. The reaction mixture was stirred at 25 °C for 16 h. Then, the reaction mixture was quenched with aqueous NH4CI, and extracted with EtOAc. The combined organic layers were dried over Na2SO4, filtered and concentrated under reduced pressure. The residue was purified by preparative TLC (silica gel, 10% MeOH in DCM) to give N-methoxy-2-(3-methoxy-5-methyl-pyrazol-l-yl)-N-methyl-6-[5- [(6-methylpyridazin-3-yl)amino]benzimidazol-l-yl]pyridine-3- carboxamide (120 mg, 0.240 mmol, 69.4% yield) as a light yellow solid. LC-MS: m/z = 500.3 [M+H] ⁺ , ESI pos.

Step 3: l-[2-(3-methoxy-5-methyl-pyrazol-l-yl)-6-[5-[(6-methylpyrida zin-3- yl)amino ]benzimidazol-l-yl ]-3-pyridyl ethanone

N-methoxy-2-(3-methoxy-5-methyl-pyrazol-l-yl)-N-methyl-6- [5-[(6-methylpyridazin-3- yl)amino]benzimidazol-l-yl]pyridine-3-carboxamide (120.0 mg, 0.240 mmol, 1.0 equiv.) was dissolved in THF (15 mL). Methyl magnesium bromide (20.0 mL, 60 mmol, 250 equiv.) was added dropwise the mixture at 0 °C. After addition, the mixture was stirred at 0 °C for 1 h. As a yellow solid precipitated out after 1 h, the mixture was further diluted with (15 mL) and stirred at 25 °C for 3 h. The resulting yellow suspension was quenched with aqueous NH4CI and extracted with EtOAc. The combined organic layers were dried over Na2SO4, filtered and concentrated under reduced pressure. The residue was purified by prep arativeTLC (silica gel, 10% MeOH in DCM) to give l-[2-(3-methoxy-5-methyl-pyrazol-l-yl)-6-[5-[(6-methylpyrida zin-3- yl)amino]benzimidazol-l-yl]-3-pyridyl]ethanone (30 mg, 0.070 mmol, 19.2% yield) as a light yellow solid. LC-MS: m/z = 455.2 [M+H] ⁺ , ESI pos. Step 4: l-[2-(3-methoxy-5-methyl-pyrazol-l-yl)-6-[5-[(6-methylpyrida zin-3- yl)amino ]benzimidazol-l-yl ]-3-pyridyl ethanol; formic acid

Prepared in analogy to Exmaple 53, step 4 using l-[2-(3-methoxy-5-methyl-pyrazol-l-yl)-6-[5- [(6-methylpyridazin-3-yl)amino]benzimidazol-l-yl]-3-pyridyl] ethanone (20.0 mg, 0.03 mmol, 1.0 equiv.) and NaBEU (6.0 mg, 0.160 mmol, 5.2 equiv.) to yield l-[2-(3-methoxy-5-methyl- pyrazol-l-yl)-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidaz ol-l-yl]-3-pyridyl]ethanol; formic acid (4.2 mg, 0.010 mmol, 24.4% yield) as light yellow solid. LC-MS: m/z = 457.2 [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, CD ₃ OD) 5 = 8.86 (s, 1H), 8.41 (d, J = 8.4 Hz, 1H), 8.34 (br s, 1H), 8.21 (d, J= 2.0 Hz, 1H), 8.15 (d, J= 9.0 Hz, 1H), 7.97 (d, J= 8.4 Hz, 1H), 7.60 (dd, J= 1.7, 8.9 Hz, 1H), 7.36 (d, J = 9.1 Hz, 1H), 7.14 (d, J = 9.1 Hz, 1H), 5.83 (s, 1H), 5.07 (q, J = 6.5 Hz, 1H), 3.90 (s, 3H), 2.53 (s, 3H), 2.35 (s, 3H), 1.43 (d, J= 6.5 Hz, 3H).

Example 215 l-[3-(l-Hydroxyethyl)-6-[6-[(2-oxo-l-piperidyl)methyl]benzim idazol-l-yl]-2-pyridyl]-5- methyl-pyrazole-3-carbonitrile

Step 1: l-[[ l-(2-trimethylsilylethoxymethyl)benzimidazol-5-yl] methyl] piper idin-2 -one

Prepared in analogy to example 212, step 3 using 2-piperidone (400.0 mg, 4.0 mmol, 1.2 equiv.) and 2-[[5-(chloromethyl)benzimidazol-l-yl]methoxy]ethyl-trimethy l-silane (1.0 g, 3.37 mmol, 1.0 equiv., prepared in example 212, step 2) to give l-[[l-(2- trimethylsilylethoxymethyl)benzimidazol-5-yl]methyl]piperidi n-2-one (200 mg, 0.560 mmol, 16.5% yield) as a colorless oil. LC-MS: m/z = 360.2 [M+H] ⁺ , ESI pos.

Step 2: l-(lH-benzimidazol-5-ylmethyl)piperidin-2-one

Prepared in analogy to example 212, step 4 using l-[[l-(2- trimethylsilylethoxymethyl)benzimidazol-5-yl]methyl]piperidi n-2-one (180.0 mg, 0.500 mmol, 1.0 equiv.) to give l-(lH-benzimidazol-5-ylmethyl)piperidin-2-one as a colorless oil which was used directly in the next step without further purification. LC-MS: m/z = 230.0 [M+H] ⁺ , ESI pos.

Step 3: l-[ 3-acetyl-6-[5-[ (2-oxo-l-piperidyl)methyl ]benzimidazol-l-yl ]-2-pyridyl ]-5-methyl- pyrazole-3-carbonitrile and l-[ 3-acetyl-6-[5-[ (2-oxo-l-piperidyl)methyl ]benzimidazol-l-yl -2- pyridyl]-5-methyl-pyrazole-3-carbonitrile

Prepared in analogy to example Example 64, step 2 using l-(3-acetyl-6-chloro-2-pyridyl)-5- methyl-pyrazole-3 -carbonitrile (120.0 mg, 0.460 mmol, 1.0 equiv., prepared in Examle 64, step 1) and l-(lH-benzimidazol-5-ylmethyl)piperidin-2-one (used as crude from the previous step) to yield l-[3-acetyl-6-[6-[(2-oxo-l-piperidyl)methyl]benzimidazol-l-y l]-2-pyridyl]-5-methyl- pyrazole-3 -carbonitrile (30 mg, 0.070 mmol, 14.37% yield) and l-[3-acetyl-6-[5-[(2-oxo-l- piperidyl)methyl]benzimidazol-l-yl]-2-pyridyl]-5-methyl-pyra zole-3-carbonitrile (30 mg, 0.070 mmol, 14.37% yield) as yellow oils after separation by preparative TLC (silica gel, 10% MeOH in DCM). Regioisomer 1 : LC-MS: m/z = 454.1 [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, DMSO- dd) 5 = 9.15 (s, 1H), 8.56 (d, J= 8.4 Hz, 1H), 8.31 (d, J= 8.6 Hz, 1H), 8.18 (d, J= 8.4 Hz, 1H), 7.65 (s, 1H), 7.31 (br d, J= 8.8 Hz, 1H), 7.13 (s, 1H), 4.63 (s, 2H), 3.21 (br s, 2H), 2.52 (br s, 3H), 2.32 (br s, 2H), 2.21 (s, 3H), 1.71 (br s, 4H). Regioisomer 2: LC-MS: m/z = 454.1 [M+H] ⁺ , ESI pos. ‘H NMR (400 MHz, DMSO-t/ ₆ ) 5 = 9.13 (s, 1H), 8.57 (d, J= 8.4 Hz, 1H), 8.30 (d, J = 8.6 Hz, 1H), 8.05 (s, 1H), 7.76 (d, J= 8.2 Hz, 1H), 7.27 (br d, J= 8.2 Hz, 1H), 7.16 (s, 1H), 4.63 (s, 2H), 3.17 (br s, 2H), 2.48 (br s, 3H), 2.21 (s, 5H), 1.59 (br s, 4H). Step 4: l-[ 3-( 1 -hydroxyethyl)-6-[ 6-[ (2-oxo-l-piperidyl)methyl ]benzimidazol-l-yl / -2-pyridyl ]-5- methyl-pyrazole-3-carbonitrile

Prepared in analogy to example 53, step 4 using l-[3-acetyl-6-[6-[(2-oxo-l- piperidyl)methyl]benzimidazol-l-yl]-2-pyridyl]-5-methyl-pyra zole-3-carbonitrile (30.0 mg, 0.070 mmol, 1.0 equiv.) and NaBH4 (8.0 mg, 0.210 mmol, 3.2 equiv.) in MeOH/THF (1 :3) to afford 1 - [3 -( 1 -hydroxyethyl)-6-[6-[(2-oxo- 1 -piperidyl)methyl]benzimidazol- 1 -yl] -2-pyridyl] - 5 - methyl-pyrazole-3 -carbonitrile (5.2 mg, 0.010 mmol, 16.8% yield) as white solid. LC-MS: m/z = 456.2 [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, DMSO-t/ ₆ ) 8 = 9.04 (s, 1H), 8.46 (d, J= 8.5 Hz, 1H), 8.26 (d, J= 8.5 Hz, 1H), 7.95 (s, 1H), 7.73 (d, J= 8.3 Hz, 1H), 7.23 (dd, J= 1.5, 8.3 Hz, 1H), 7.12 (d, J= 0.8 Hz, 1H), 5.54 (d, = 4.4 Hz, 1H), 4.61 (s, 2H), 4.55 - 4.47 (m, 1H), 3.15 (br t, J= 5.6 Hz, 2H), 2.31 (s, 3H), 2.18 (t, J= 6.3 Hz, 2H), 1.65 - 1.53 (m, 4H), 1.25 (d, J= 6.5 Hz, 3H).

Example 216 l-[3-(l-Hydroxyethyl)-6-[5-[(2-oxo-l-piperidyl)methyl]benzim idazol-l-yl]-2-pyridyl]-5- methyl-pyrazole-3-carbonitrile

Prepared in analogy to example 53, step 4 using l-[3-acetyl-6-[5-[(2-oxo-l- piperidyl)methyl]benzimidazol-l-yl]-2-pyridyl]-5-methyl-pyra zole-3-carbonitrile (30.0 mg, 0.070 mmol, 1.0 equiv., obtained in example 215, step 3) and NaBH4 (8.0 mg, 0.210 mmol, 3.2 equiv.) in MeOH/THF (1 :3) to afford l-[3-(l-hydroxyethyl)-6-[5-[(2-oxo-l- piperidyl)methyl]benzimidazol-l-yl]-2-pyridyl]-5-methyl-pyra zole-3-carbonitrile (6.5 mg, 0.010 mmol, 21.1% yield) as white solid. LC-MS: m/z = 456.2 [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, DMSO-i/,) 8 = 9.04 (s, 1H), 8.46 (d, J = 8.5 Hz, 1H), 8.27 (d, J = 8.5 Hz, 1H), 8.07 (d, J = 8.5 Hz, 1H), 7.63 (s, 1H), 7.27 (dd, J= 1.3, 8.4 Hz, 1H), 7.09 (d, J= 0.6 Hz, 1H), 5.64 - 5.46 (m, 1H), 4.62 (s, 2H), 4.56 (q, J= 6.3 Hz, 1H), 3.20 (br s, 2H), 2.34 (s, 3H), 2.32 (br d, J= 2.6 Hz, 2H), 1.70 (br t, J= 3.3 Hz, 4H), 1.26 (d, J= 6.5 Hz, 3H).

Example 219 3-[[l-[6-(3-Cyano-5-methyl-pyrazol-l-yl)-5-(l-hydroxyethyl)- 2-pyridyl]benzimidazol-5- yl]amino]-N,N,6-trimethyl-pyridazine-4-carboxamide

Step 1: 3-chloro-N,N,6-trimethyl-pyridazine-4-carboxamide

To a solution of 3-chloro-6-methylpyridazine-4-carboxylic acid (900.0 mg, 5.22 mmol, 1.0 equiv.) in DMF (10 mL) were added dimethylamine hydrochloride (510.3 mg, 6.26 mmol, 1.2 equiv.), DIPEA (2.73 mL, 15.65 mmol, 3 equiv.) and HATU (1.84 g, 7.82 mmol, 1.5 equiv.). The reaction mixture was stirred at 30 °C for 16 h. The reaction mixture was poured into water and extracted with EtOAc and DCM. The combined organic layers were dried over Na2SO4, and the volatiles evaporated. The crude product was purified by flash column chromatography (0 - 100% EtOAc in PE). Further purification by preparative HPLC (Phenomenex luna Cl 8 150 mm x 40 mm x 15 pm, gradient 1 - 30% CH3CN in H2O (with 0.225% formic acid) over 13 min, then 100% CH3CN (2 min), flow rate 60 mL/min) to give 3-chloro-N,N,6-trimethyl-pyridazine- 4-carboxamide (350 mg, 1.75 mmol, 33.62% yield) as yellow solid. LC-MS: m/z = 200.0 [M+H] ⁺ , ESI pos.

Step 2: 3-amino-N,N, 6-trimethyl-pyridazine-4-carboxamide

A solution of 3-chloro-N,N,6-trimethyl-pyridazine-4-carboxamide (300.0 mg, 1.5 mmol, 1.0 equiv.) in 7M NH3 in MeOH (8.0 mL, 56 mmol, 37 equiv.) in an autoclave was stirred at 120 °C for 72 h. The reaction mixture was concentrated under reduced pressure. The crude was purified by preparative HPLC (Waters Atlantis 150 mm x 30 mm x 5 pm, gradient 1 - 20% CH3CN in H2O (with 0.225% formic acid) over 10 min, then 100% CH3CN (2 min), flow rate 25 mL/min). The resulting product was purified by preparative TLC (10% MeOH in DCM) to yield 3-amino- N,N,6-trimethyl-pyridazine-4-carboxamide (48 mg, 0.270 mmol, 17.4% yield) as an off-white solid. LC-MS: m/z = 181.0 [M+H] ⁺ , ESI pos. 'HNMR (400 MHz, CDCI3) 8 = 6.92 (s, 1H), 5.24 (br s, 2H), 3.10 - 3.01 (m, 3H), 2.94 (br d, J= 9.9 Hz, 3H), 2.51 (s, 3H).

Step 3: 3-[[ l-[5-acetyl-6-(3-cyano-5-methyl-pyrazol-l-yl)-2-pyridyl ]benzimidazol-5-yl ] amino ]-

N,N,6-trimethyl-pyridazine-4-carboxamide

Prepared in analogy to example 104, step 2 using l-[3-acetyl-6-(5-bromobenzimidazol-l-yl)-2- pyridyl]-5-methyl-pyrazole-3-carbonitrile (30 mg, 0.071 mmol, 1.0 equiv., prepared in example 65, step 1) and 3-amino-N,N,6-trimethyl-pyridazine-4-carboxamide (25.67 mg, 0.142 mmol, 2.0 equiv.) to yield the title compound (14.2 mg, 36.4% yield) as a yellow solid. LC-MS: m/z = 521.3 [M+H] ⁺ , ESI pos.

Step 4: 3-[[l-[6-(3-cyano-5-methyl-pyrazol-l-yl)-5-(l-hydroxyethyl)- 2-pyridyl]benzimidazol-5- yl amino J-N,N, 6-trimethyl-pyridazine-4-carboxamide Prepared in analogy to example 53, step 4 using 3-[[l-[5-acetyl-6-(3-cyano-5-methyl-pyrazol-l- yl)-2-pyridyl]benzimidazol-5-yl]amino]-N,N,6-trimethyl-pyrid azine-4-carboxamide (14.2 mg, 0.027 mmol, 1.0 equiv.) in MeOH/THF to yield the title compound (7.7 mg, 51.3% yield) as a light yellow solid. LC-MS: m/z = 523.3 [M+H] ⁺ , ESI pos. Example 220

5-Hydroxy-2- [3-(l-hydroxyethyl)-6- [5- [(6-methylpyridazin-3-yl)amino] benzimidazol- 1-yl] - 2-pyridyl] benzonitrile; formic acid

Step 1 : 2-[ 3-acetyl-6-[5-[ ( 6-methylpyridazin-3-yl)amino ] benzimidazol- 1-yl / -2-pyridyl ]-5- hydroxy-benzonitrile

Prepared in analogy to example 143, step 2 using l-[2-chloro-6-[5-[(6-methylpyridazin-3- yl)amino]benzimidazol-l-yl]-3-pyridyl]ethanone (50.0 mg, 0.130 mmol, 1.0 equiv., prepared in example 65, step 1) and (2-cyano-4-hydroxy-phenyl) (25.81 mg, 0.160 mmol, 1.2 equiv.) to yield 2-[3-acetyl-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol -l-yl]-2-pyridyl]-5-hydroxy- benzonitrile (30 mg, 0.070 mmol, 49.3% yield) as a yellow solid LC-MS: m/z = 462.2 [M+H] ⁺ ,

ESI pos.

Step 2: 5-hydroxy-2-[ 3-( I -hydroxyethyl)-6-[5-[ ( 6-methylpyridazin-3-yl)amino ] benzimidazol- 1- y I] -2-pyridyl benzonitrile; formic acid

Prepared in analogy to example 53, step 4 using 2-[3-acetyl-6-[5-[(6-methylpyridazin-3- yl)amino]benzimidazol-l-yl]-2-pyridyl]-5-hydroxy-benzonitril e (30.0 mg, 0.070 mmol, 1.0 equiv.) and NaBH4 (12.36 mg, 0.330 mmol, 5.0 equiv.) to yield 5 -hydroxy-2- [3 -(1- hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidaz ol-l-yl]-2-pyridyl]benzonitrile; formic acid (4.5 mg, 0.010 mmol, 15.0% yield) as a white. LC-MS: m/z = 464.1 [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, CD ₃ OD) 5 = 8.85 (s, 1H), 8.36 (d, J = 8.4 Hz, 1H), 8.32 - 8.25 (m, 1H), 8.23 - 8.12 (m, 2H), 7.96 (d, J= 8.4 Hz, 1H), 7.62 - 7.54 (m, 1H), 7.50 (d, J= 8.4 Hz, 1H), 7.36 (d, J= 9.2 Hz, 1H), 7.30 (d, J= 2.4 Hz, 1H), 7.26 - 7.18 (m, 1H), 7.14 (d, J = 92 Hz, 1H), 4.90 (s, 1H), 2.53 (s, 3H), 1.42 (d, J= 6.4 Hz, 3H).

Example 223

5- [3-(l-Hydroxyethyl)-6- [5- [(6-methylpyridazin-3-yl)amino] benzimidazol-l-yl]-2-pyridyl]- 3-(trifluoromethyl)-lH-pyridazin-6-one; formic acid Step 1: l-[2-[3-methoxy-6-(trifluoromethyl)pyridazin-4-yl]-6-[5-[(6- methylpyridazin-3- yl)amino ]benzimidazol-l-yl ]-3-pyridyl ethanone

Prepared in analogy to example 143, step 2 using l-[2-chloro-6-[5-[(6-methylpyridazin-3- yl)amino]benzimidazol-l-yl]-3-pyridyl]ethanone (80.0 mg, 0.210 mmol, 1.0 equiv., prepared in example 76, step 2) and l-[2-chloro-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol -l-yl]-3- pyridyl] ethanone (80.0 mg, 0.210 mmol, 1.0 equiv.) to yield l-[2-[3-methoxy-6- (trifluoromethyl)pyridazin-4-yl]-6-[5-[(6-methylpyridazin-3- yl)amino]benzimidazol-l-yl]-3- pyridyl] ethanone (25 mg, 0.050 mmol, 22.8% yield) as yellow solid. LC-MS: m/z = 521.3 [M+H] ⁺ , ESI pos.

Step 2: 5-[ 3-acetyl-6-[5-[ ( 6-methylpyridazin-3-yl)amino ]benzimidazol-l-yl ]-2-pyridyl ]-3- ( trifluoromethyl) -lH-pyridazin-6-one

A solution of l-[2-[3-methoxy-6-(trifluoromethyl)pyridazin-4-yl]-6-[5-[(6- methylpyridazin-3- yl)amino]benzimidazol-l-yl]-3-pyridyl]ethanone (20.0 mg, 0.040 mmol, 1.0 equiv.) in 37% aqueous HC1 (0.16 mL, 2 mmol, 50 equiv.) was stirred at 100 °C for 3h. The reaction mixture was concentrated under reduced pressure and purified by preparative HPLC (Phenomenex luna C18 (250x70mm, 10 um), water (0.225%FA) - CH3CN, 12 - 42% B, gradient time 20 min, 2 min 100% B hold time, flow rate 25 mL/min) to yield 5-[3-acetyl-6-[5-[(6-methylpyridazin-3- yl)amino]benzimidazol-l-yl]-2-pyridyl]-3-(trifluoromethyl)-l H-pyridazin-6-one (19 mg, 0.040 mmol, 97.6% yield) as a yellow solid. LC-MS: m/z =506.9 [M+H] ⁺ , ESI pos. Step 3: 5-[ 3-( 1 -hydroxyethyl)-6-[5-[ ( 6-methylpyridazin-3-yl)amino ]benzimidazol-l-yl ]-2- pyridyl -3-( trifluor omethyl)-lH-pyridazin-6-one; formic acid Prepared in analogy to example 53, step 4 using 5-[3-acetyl-6-[5-[(6-methylpyridazin-3- yl)amino]benzimidazol-l-yl]-2-pyridyl]-3-(trifluoromethyl)-l H-pyridazin-6-one (15.0 mg, 0.030 mmol, 1.0 equiv.) and NaBELj (5.63 mg, 0.150 mmol, 5.0 equiv.) to yield 5-[3-(l-hydroxyethyl)- 6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-l-yl]-2-pyr idyl]-3-(trifluoromethyl)-lH- pyridazin-6-one; formic acid (3.3 mg, 0.010 mmol, 21.9% yield) as yellow solid. LC-MS: m/z = 509.1 [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, CD ₃ OD) 5 = 8.85 (s, 1H), 8.32 (d, J= 8.8 Hz, 1H), 8.26 (s, 1H), 8.23 - 8.09 (m, 2H), 8.05 - 7.95 (m, 2H), 7.62 - 7.52 (m, 1H), 7.36 (d, J = 9.2 Hz, 1H), 7.14 (d, J= 9.2 Hz, 1H), 4.89 (s, 1H), 2.53 (s, 3H), 1.49 (d, J= 6.4 Hz, 3H).

Example 226

2- [3-(l-Hydroxyethyl)-6- [5- [(6-methylpyridazin-3-yl)amino] benzimidazol- 1-yl] -2- pyridyl]furan-3-carbonitrile

Step 1 : 2-[ 3-acetyl-6-[5-[ ( 6-methylpyridazin-3-yl)amino ] benzimidazol- 1-yl / -2 -pyridyl ]furan-3- carbonitrile

Prepared in analogy to example 143, step 2 using (3-cyano-2-furyl)boronic acid (27.1 mg, 0.200 mmol, 1.5 equiv.) and l-[2-chloro-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol -l-yl]-3- pyridyl] ethanone (50.0 mg, 0.130 mmol, 1.0 equiv., prepared in example 64, step 1), to yield 2- [3-acetyl-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-l -yl]-2-pyridyl]furan-3-carbonitrile (20 mg, 0.050 mmol, 26.5% yield) as a yellow solid LC-MS: m/z = 436.1, [M+H] ⁺ , ESI pos.

Step 2: 2-[ 3-( 1 -hydroxyethyl)-6-[5-[ ( 6-methylpyridazin-3-yl)amino ]benzimidazol-l-yl ]-2- pyridyl ]furan-3-carbonitrile

Prepared in analogy to example 53, step 4 using 2-[3-acetyl-6-[5-[(6-methylpyridazin-3- yl)amino]benzimidazol-l-yl]-2-pyridyl]furan-3-carbonitrile (20.0 mg, 0.050 mmol, 1.0 equiv.) and NaBH4 (8.69 mg, 0.230 mmol, 5.0 equiv.) to yield 2-[3-(l-hydroxyethyl)-6-[5-[(6- methylpyridazin-3-yl)amino]benzimidazol-l-yl]-2-pyridyl]fura n-3-carbonitrile (1 mg, 4.98% yield) as a white solid. LC-MS: m/z = 438.2, [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, DMSO-t/ ₆ ) 5 = 9.23 (s, 1H), 9.02 (s, 1H), 8.45 - 8.41 (m, 2H), 8.36 (s, 1H), 8.22 - 8.18 (m, 2H), 8.13 (d, J= 8.6 Hz, 1H), 7.55 (dd, J= 2.0, 8.8 Hz, 1H), 7.33 (d, J= 9.2 Hz, 1H), 7.27 (d, J = 2.0 Hz, 1H), 7.08 (d, J= 9.2 Hz, 1H), 5.35 (q, J= 6.4 Hz, 1H), 2.48 (s, 3H), 1.42 (d, J= 6.4 Hz, 3H).

Example 227 l-[2-[2-(2,2-Difluorocyclopropyl)pyrazol-3-yl]-6-[5-[(6-meth ylpyridazin-3- yl)amino]benzimidazol-l-yl]-3-pyridyl]ethanol; formic acid

Step 1: [2-(2,2-difluorocyclopropyl)pyrazol-3-yl]boronic acid Prepared in analogy to example 143, step 2 using 5-bromo-l-(2,2-difluorocyclopropyl)pyrazole (80.0 mg, 0.360 mmol, 1.0 equiv. to yiekd bis(pinacolato)diboron (136.64 mg, 0.540 mmol, 1.5 equiv.), potassium acetate (0.07 mL, 1.08 mmol, 3 equiv.) [2-(2,2-difluorocyclopropyl)pyrazol- 3-yl]boronic acid which was used in the next step without purification.LC-MS: m/z = 189.1, [M+H] ⁺ , ESI pos. Step 2: l-[2-[2-(2,2-difluorocyclopropyl)pyrazol-3-yl]-6-[5-[(6-meth ylpyridazin-3- yl) amino ]benzimidazol-l-yl ]-3-pyridyl ] ethanone

Prepared in analogy to example 143, step 2 using l-[2-chloro-6-[5-[(6-methylpyridazin-3- yl)amino]benzimidazol-l-yl]-3-pyridyl]ethanone (30.0 mg, 0.080 mmol, 1.0 equiv., prepared in example 76, step 2) and [2-(2,2-difluorocyclopropyl)pyrazol-3-yl]boronic acid (used as crude from the previous step), to yield l-[2-[2-(2,2-difluorocyclopropyl)pyrazol-3-yl]-6-[5-[(6- methylpyridazin-3-yl)amino]benzimidazol-l-yl]-3-pyridyl]etha none (17 mg, 0.030 mmol, 35.7% yield) as a yellow solid. LC-MS: m/z = 487.1, [M+H] ⁺ , ESI pos. Step 3: l-[2-[2-(2,2-difluorocyclopropyl)pyrazol-3-yl]-6-[5-[(6-meth ylpyridazin-3- yl)amino ]benzimidazol-l-yl ]-3-pyridyl ethanol; formic acid

Prepared in analogy to example 53, step 4 using l-[2-[2-(2,2-difluorocyclopropyl)pyrazol-3-yl]- 6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-l-yl]-3-pyr idyl]ethanone (15.0 mg, 0.030 mmol, 1.0 equiv.) and NaBELj (5.83 mg, 0.150 mmol, 5.0 equiv.) at -70 °C to yield l-[2-[2-(2,2- difluorocyclopropyl)pyrazol-3-yl]-6-[5-[(6-methylpyridazin-3 -yl)amino]benzimidazol-l-yl]-3- pyridyl] ethanol; formic acid (3.7 mg, 0.010 mmol, 22.5% yield) as a yellow solid. LC-MS: m/z = 489.3, [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, CD ₃ OD) 5 = 8.88 (s, 1H), 8.41 (d, J = 8.6 Hz, 1H), 8.24 (s, 1H), 8.20 (d, J= 2.0 Hz, 1H), 8.09 (d, J= 9.2 Hz, 1H), 8.00 (d, J= 8.6 Hz, 1H),

7.69 (d, J= 2.0 Hz, 1H), 7.59 (dd, J= 2.0, 8.8 Hz, 1H), 7.37 (d, J= 92 Hz, 1H), 7.15 (d, J= 92 Hz, 1H), 6.68 (d, J= 2.0 Hz, 1H), 5.07 (q, J = 6.4 Hz, 1H), 4.47 - 4.38 (m, 1H), 2.53 (s, 3H), 2.23 - 2.05 (m, 2H), 1.50 (d, J= 6.4 Hz, 3H).

Example 228 1- [3-(l-Hydroxyethyl)-6- [5- [[6-(oxetan-3-yl)pyridazin-3-yl]amino] benzimidazol-l-yl]-2- pyridyl]-5-methyl-pyrazole-3-carbonitrile Step 1 :6-(oxetan-3-yl)pyridazin-3-amine; formic acid

A 8 mL vial equipped with a stir bar was charged with 3-amino-6-bromopyridazine (1.0 g, 5.75 mmol, 1.0 equiv.), 3-iodooxetane (1.37 g, 7.47 mmol, 1.3 equiv.), Ir[dF(CF3)ppy]2(dtbpy)(PFe) (64.94 mg, 0.060 mmol, 0.01 equiv.), NiCh dtbbpy (77.13 mg, 0.290 mmol, 0.050 equiv.), tris(trimethylsilyl)silane (1.43 g, 5.75 mmol, 1.0 equiv.) and ISfeCCL (1.22 g, 11.49 mmol, 2.0 equiv.) in DME (80 mL).The vial was sealed and placed under nitrogen. The reaction was stirred and irradiated with a 34 W blue LED lamp (distanced at 7 cm), in presence of a cooling fan to maintain the reaction at 25 °C for 14 h.The reaction mixture was quenched with water and extracted with ethyl acetate. And the combined aqueous phase was concentrated under reduced pressure to give a residue. The residue was preparative HPLC (Waters Atlantis T3 150 mm x 30mm x 5 pm, gradient 1 - 20% CH3CN in H2O (with 0.225% formic acid) overl08 min, then 100% CH3CN (2 min), flow rate 25 mL/min) to give 6-(ox etan-3 -yl)pyridazin-3 -amine; formic acid (65.8 mg, 0.330 mmol, 5.8% yield) as brown solid. LC-MS: m/z = 152.0 [M+H] ⁺ , ESI pos. ^J H NMR (400 MHz, DMSO-t/ ₆ ) 5 = 8.13 (s, 1H), 7.43 (d, J= 9.1 Hz, 1H), 6.93 (d, J= 9.1 Hz, 1H), 6.75 (br s, 2H), 4.88 (dd, J= 5.9, 8.4 Hz, 2H), 4.72 (t, J= 6.2 Hz, 2H), 4.33 (td, J= 7.6, 15.1 Hz, 1H).

Step 2: l-[ 3-acetyl-6-[5-[[ 6-(oxetan-3-yl)pyridazin-3-yl ] amino ]benzimidazol-l-yl ]-2-pyridyl ]- 5-methyl-pyrazole-3-carbonitrile

Prepared in analogy to example 104, step 2 using l-[3-acetyl-6-(5-bromobenzimidazol-l-yl)-2- pyridyl]-5-methyl-pyrazole-3-carbonitrile (30 mg, 0.071 mmol, 1 equiv., prepared in example 65, step 1) and [6-(oxetan-3-yl)pyridazin-3-yl]amine; formic acid (28.1 mg, 0.142 mmol, 2.0 equiv.) to yield the title compound (14.8 mg, 40.2% yield) as a yellow solid. LC-MS: m/z = 492.3 [M+H] ⁺ , ESI pos. Step 3: l-[ 3-( 1 -hydroxyethyl)-6-[5-[[ 6-(oxetan-3-yl)pyridazin-3-yl ] amino ]benzimidazol-l-yl ]-2- pyridyl]-5-methyl-pyrazole-3-carbonitrile

Prepared in analogy to example 53, step 1 using l-[3-acetyl-6-[5-[[6-(oxetan-3-yl)pyridazin-3- yl]amino]benzimidazol-l-yl]-2-pyridyl]-5-methyl-pyrazole-3-c arbonitrile (14.8 mg, 0.029 mmol, 1.0 equiv.) in MeOH/THF (1 : 1) to yield the title compound (7.7 mg, 53.8% yield) as a light yellow solid. LC-MS: m/z = 494.3 [M+H] ⁺ , ESI pos.

Example 229

(1 S )- 1 - 12- [3-(Difluoromethyl)-5-methyl-pyrazol-l-yl]-6- [5- [(6-methylpyridazin-3- yl)amino]benzimidazol-l-yl]-3-pyridyl]ethanol

The enantiomers of l-[2-[3-(difluoromethyl)-5-methyl-pyrazol-l-yl]-6-[5-[(6-met hylpyridazin-3- yl)amino]benzimidazol-l-yl]-3-pyridyl]ethanol (121.5 mg, 0.255 mmol, 1 equiv., from example 129) were separated by chiral SFC (chiral OJ-H 250 mm x 20 mm x 5 pm, 18% MeOH (with 0.2% diethylamine)) to yield (lS)-l-[2-[3-(difhroromethyl)-5-methyl-pyrazol-l-yl]-6-[5-[( 6- methylpyridazin-3-yl)amino]benzimidazol-l-yl]-3-pyridyl]etha nol (43 mg, 34.3%, 95.6% ee) as off-white lyophilized solid. Assignment of the absolute stereochemistry was done in analogy to examples 109 and 110. Example 230 (lR)-l-[2-[3-(Difluoromethyl)-5-methyl-pyrazol-l-yl]-6-[5-[( 6-methylpyridazin-3- yl)amino]benzimidazol-l-yl]-3-pyridyl]ethanol

The enantiomers of l-[2-[3-(difluoromethyl)-5-methyl-pyrazol-l-yl]-6-[5-[(6-met hylpyridazin-3- yl)amino]benzimidazol-l-yl]-3-pyridyl]ethanol (121.5 mg, 0.255 mmol, 1 equiv., from example 129) were separated by chiral FC (chiral OJ-H 250 mm x 20 mm x 5 pm, 18% MeOH (with 0.2% diethylamine)) to yield (lR)-l-[2-[3-(difluoromethyl)-5-methyl-pyrazol-l-yl]-6-[5-[( 6- methylpyridazin-3-yl)amino]benzimidazol-l-yl]-3-pyridyl]etha nol (50 mg, 41.2%, 100% ee). Assignment of the absolute stereochemistry was done in analogy to examples 109 and 110.

Example 231

1- [2- [5-(difluoromethyl)-3-methyl-pyrazol- 1-yl] -6- [5- [(6-methylpyridazin-3- yl)amino]benzimidazol-l-yl]-3-pyridyl]ethanol

Was obtained in example 129 from the reduction of the trace mounts of l-[2-[5- (difluoromethyl)-3-methyl-pyrazol-l-yl]-6-[5-[(6-methylpyrid azin-3-yl)amino]benzimidazol-l- yl]-3-pyridyl]ethanone contained in l-[2-[3-(difluoromethyl)-5-methyl-pyrazol-l-yl]-6-[5-[(6- methylpyridazin-3-yl)amino]benzimidazol-l-yl]-3-pyridyl]etha none to give l-[2-[5- (difluoromethyl)-3-methyl-pyrazol-l-yl]-6-[5-[(6-methylpyrid azin-3-yl)amino]benzimidazol-l- yl]-3-pyridyl]ethanol (3.4 mg, 2.24% yield) as a white solid after purification SFC (chiral OJ-H 250 mm x 20 mm x 5 pm, 18% MeOH (with 0.2% di ethylamine)). LC-MS: m/z = 477.2 [M+H] ⁺ , ESI pos. 'H NMR (600 MHz, CDC1 ₃ ) 6 = 8.54 (s, 1 H), 8.27 (d, J= 8.3 Hz, 1 H), 7.89 (d, J= 8.7 Hz, 1 H), 7.78 (d, J= 1.9 Hz, 1H), 7.62 (d, J= 8.2 Hz, 1 H), 7.38 (dd, J= 8.7, 2.1 Hz, 1 H), 7.24 - 7.26 (m, 1 H), 7.12 - 7.15 (m, 1 H), 7.01 - 7.09 (m, 1 H), 6.97 - 7.05 (m, 1 H), 6.67 - 6.68 (m, 1 H), 5.05 - 5.20 (m, 1 H), 4.99 (q, J= 6.5 Hz, 1 H), 2.59 - 2.61 (m, 4 H), 2.43 (s, 3 H), 1.57 - 1.58 (m, 10 H).

Example 234

1- [3-(l-Hydroxy-2-methoxy-ethyl)-6- [5- [(6-methylpyridazin-3-yl)amino] benzimidazol-1- yl]-2-pyridyl]-5-methyl-pyrazole-3-carbonitrile; formic acid

Step 1: l-[6-chloro-3-(2-methoxyacetyl)-2-pyridyl]-5-methyl-pyrazole -3-carbonitrile

A mixture of 5-methyl-lH-pyrazole-3-carbonitrile (315.7 mg, 2.95 mmol, 1.0 equiv.), DIPEA (1.0 mL, 5.89 mmol, 2.0 equiv.) and l-(6-chloro-2-fluoro-3-pyridyl)-2-m ethoxy-ethanone (600.0 mg, 2.95 mmol, 1.0 equiv.) in DMSO (10 mL) was stirred at 100 °C for 3 h. The reaction mixture poured into water and extracted with EtOAc, the combined organic layers were dried and concentrated under vacuum. The combined residue was purified by flash column chromatography (silica gel, 25% EtOAc, in PE) to give l-[6-chloro-3-(2-methoxyacetyl)-2- pyridyl]-5-methyl-pyrazole-3-carbonitrile (500 mg, 1.72 mmol, 58.4% yield) as a yellow gum. ^J H NMR (400 MHz, CDCI3) 8 = 7.91 (d, J= 8.0 Hz, 1H), 7.48 (d, J= 8.0 Hz, 1H), 6.63 (s, 1H), 4.05 (s, 2H), 3.19 (s, 3H), 2.66 (s, 3H).

Step 2: l-[ 3-(2-methoxyacetyl)-6-[5-[ ( 6-methylpyridazin-3-yl)amino ]benzimidazol-l-yl -2- pyridyl ]-5-methyl-pyrazole-3-carbonitrile and l-[ 3-(2-methoxyacetyl)-6-[ 6-[ ( 6-methylpyridazin-

3-yl) amino Jbenzimidazol-l-yl -2-pyridyl / -5 -methyl-pyr azole- 3 -carbonitrile

Prepared in analogy to example 76, step 1 using l-[6-chloro-3-(2-methoxyacetyl)-2-pyridyl]-5- methyl-pyrazole-3 -carbonitrile (500.0 mg, 1.72 mmol, 1.0 equiv.), DIPEA (0.6 mL, 3.44 mmol, 2 equiv.) and N-(6-methylpyridazin-3-yl)-lH-benzimidazol-5-amine (387.41 mg, 1.72 mmol, 1.0 equiv., prepared in example 64, intermediate 1) to yield l-[3-(2-methoxyacetyl)-6-[5-[(6- methylpyridazin-3-yl)amino]benzimidazol-l-yl]-2-pyridyl]-5-m ethyl-pyrazole-3-carbonitrile (30 mg, 0.060 mmol, 3.6% yield) and l-[3-(2-methoxyacetyl)-6-[6-[(6-methylpyridazin-3- yl)amino]benzimidazol-l-yl]-2-pyridyl]-5-methyl-pyrazole-3-c arbonitrile (20 mg, 0.040 mmol, 2.4% yield) as two grey solid after separation by preparative HPLC (Phenomenex luna C18 150 mm x 25mm x 10 pm, gradient 14 - 34% CH3CN in H2O (with 0.225% formic acid) over 10 min, then 100% CH3CN (5 min), flow rate 25 mL/min) and preparative NPLC (Welch Ultimate XB-SiOH 250 mm x 50 mm x 10 pm, gradient 29 - 45% EtOH (with 0.1% ammonium hydroxide) in hexane over 15 min, then 100% EtOH (with 0.1% ammonium hydroxide) (5 min), flow rate 100 mL/min, 1 injection). LC-MS: m/z = 480.3 [M+H] ⁺ , ESI pos.

Step 3: l-[ 3-( 1 -hydroxy-2-methoxy-ethyl)-6-[5-[ ( 6-methylpyridazin-3-yl)amino ]benzimidazol-l- y I] -2 -pyridyl ]-5-methyl-pyrazole-3-carbonitrile; formic acid o HO—

Prepared in analogy to example 53, step 4 using l-[3-(2-methoxyacetyl)-6-[5-[(6- methylpyridazin-3-yl)amino]benzimidazol-l-yl]-2-pyridyl]-5-m ethyl-pyrazole-3-carbonitrile (30.0 mg, 0.060 mmol, 1.0 equiv.) to give l-[3-(l-hydroxy-2-methoxy-ethyl)-6-[5-[(6- methylpyridazin-3-yl)amino]benzimidazol-l-yl]-2-pyridyl]-5-m ethyl-pyrazole-3-carbonitrile; formic acid (13.6 mg, 0.030 mmol, 45.1% yield) as a yellow soli. LC-MS: m/z = 482.2 [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, DMSO-t/ ₆ ) 6 = 8.94 (s, 1H), 8.40 (d, J= 8.6 Hz, 1H), 8.35 (s, 1H), 8.17 (d, J= 8.7 Hz, 1H), 8.13 - 8.10 (m, 1H), 8.03 (d, J= 8.8 Hz, 1H), 7.51 - 7.46 (m, 1H), 7.37 (d, J = 9.2 Hz, 1H), 7.12 (d, J= 9.2 Hz, 1H), 7.02 (s, 1H), 4.60 (t, J= 5.5 Hz, 1H), 3.36 (t, J = 5.1 Hz, 2H), 3.14 (s, 3H), 2.46 (s, 3H), 2.32 (s, 3H).

Example 235

1- [3-(l-Hydroxy-2-methoxy-ethyl)-6- [6- [(6-methylpyridazin-3-yl)amino] benzimidazol-1- yl]-2-pyridyl]-5-methyl-pyrazole-3-carbonitrile

Prepared in analogy to example 53, step 4 using l-[3-(2-methoxyacetyl)-6-[6-[(6- methylpyridazin-3-yl)amino]benzimidazol-l-yl]-2-pyridyl]-5-m ethyl-pyrazole-3-carbonitrile (20.0 mg, 0.040 mmol, 1.0 equiv., prepared in example 234, step 2) to give l-[3-(l-hydroxy-2- methoxy-ethyl)-6-[6-[(6-methylpyridazin-3-yl)amino]benzimida zol-l-yl]-2-pyridyl]-5-methyl- pyrazole-3 -carbonitrile (4.4 mg, 0.010 mmol, 21.9% yield) as a yellow solid. LC-MS: m/z = 482.2 [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, CD ₃ OD) 5 = 8.80 (s, 1H), 8.76 (d, J= 1.8 Hz, 1H), 8.55 (d, J= 8.6 Hz, 1H), 8.15 (d, J= 8.3 Hz, 1H), 7.69 (d, J= 8.8 Hz, 1H), 7.45 (dd, J= 2.0, 8.7 Hz, 1H), 7.36 (d, J = 9.2 Hz, 1H), 7.15 (d, J= 92 Hz, 1H), 6.81 (s, 1H), 4.68 - 4.61 (m, 1H), 3.58 - 3.48 (m, 2H), 3.30 (br s, 3H), 2.56 (s, 3H), 2.39 (s, 3H).

Example 236

1- [6- [6-Fluoro-5- [(6-methylpyridazin-3-yl)amino] benzimidazol-l-yl]-3-[(l S)-l- hydroxyethyl]-2-pyridyl]-5-methyl-pyrazole-3-carbonitrile The two enantiomers of l-[6-[6-fluoro-5-[(6-methylpyridazin-3-yl)amino]benzimidazol -l-yl]-3- (l-hydroxyethyl)-2-pyridyl]-5-methyl-pyrazole-3-carbonitrile (120.0 mg, from Example 93/94, step 6) were separated by chiral SFC (Daicel Chiralpak AS 250 mm x 30mm x 10 pm, 35% MeOH (with 0.1% ammonium hydroxide) over 30 min, 65 mL/min flow rate) to yield l-[6-[6- fluoro-5-[(6-methylpyridazin-3-yl)amino]benzimidazol-l-yl]-3 -[(lS)-l-hydroxyethyl]-2- pyridyl]-5-methyl-pyrazole-3-carbonitrile (44 mg, 0.090 mmol, 36.67% yield) as light yellow solid. (S)-isomer: LC-MS: m/z = 470.0 [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, CD3OD) 5 = 8.94 (s, 1H), 8.54 (dd, J= 7.9, 15.9 Hz, 2H), 8.17 (d, J= 8.6 Hz, 1H), 8.01 (d, J= 11.2 Hz, 1H), 7.40 (d, J= 9.2 Hz, 1H), 7.22 (d, J= 9.0 Hz, 1H), 6.90 (s, 1H), 4.78 (q, J= 6.3 Hz, 1H), 2.56 (s, 3H), 2.43 (s, 3H), 1.43 (d, J = 6.5 Hz, 3H). Assignment of the absolute stereochemistry was done in analogy to examples 109 and 110.

Example 237 l-[6-[6-Fluoro-5-[(6-methylpyridazin-3-yl)amino]benzimidazol -l-yl]-3-[(lR)-l- hydroxyethyl]-2-pyridyl]-5-methyl-pyrazole-3-carbonitrile l-[6-[6-fluoro-5-[(6-methylpyridazin-3-yl)amino]benzimidazol -l-yl]-3-[(lA)-l-hydroxyethyl]-2- pyridyl]-5-methyl-pyrazole-3-carbonitrile (50 mg, 0.110 mmol, 41.7% yield) was obtained as white solid after separation of both enantiomers by chiral SFC (Daicel Chiralpak AS 250 mm x 30mm x 10 pm, 35% MeOH (with 0.1% ammonium hydroxide) over 30 min, 65 mL/min flow rate). (A)-isomer: LC-MS: m/z = 470.0 [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, CD ₃ OD) 5 = 8.94 (s, 1H), 8.54 (dd, J= 7.9, 13.8 Hz, 2H), 8.17 (d, J= 8.6 Hz, 1H), 8.01 (d, J= 11.4 Hz, 1H), 7.41 (d, J = 9.2 Hz, 1H), 7.23 (d, J= 92 Hz, 1H), 6.90 (s, 1H), 4.78 (q, J= 6.4 Hz, 1H), 2.56 (s, 3H), 2.43 (s, 3H), 1.43 (d, J = 6.4 Hz, 3H). Assignment of the absolute stereochemistry was done in analogy to examples 109 and 110. Example 239

1- [5-Chloro-3-(l-hydroxyethyl)-6- [5- [(6-methylpyridazin-3-yl)amino] benzimidazol-l-yl]-2- pyridyl] pyrazole-3-carbonitrile

Step 1: 2,5,6-trichloropyridine-3-carbonyl chloride

To a suspension of 2,5,6-trichloronicotinic acid (5.0 g, 22.08 mmol, 1.0 equiv.) in DCM (50 mL) were added dropwise oxalyl chloride (4.3 mL, 50.79 mmol, 2.3 equiv.) and DMF (161.39 mg, 2.21 mmol, 0.10 equiv.) at 0 °C. The reaction mixture was stirred at RT for 30 minutes. The resulting clear solution was concentrated to dryness yield 2,5,6-trichloropyridine-3-carbonyl chloride as light yellow oil which was used in the ext step without further purification. LC-MS: m/z = 239.9 [M+H] ⁺ , ESI pos.

Step 2: 2, 5, 6-trichloro-N-methoxy-N-methyl-pyridine-3-carboxamide

To a suspension of 2,5,6-trichloropyridine-3-carbonyl chloride (used as crude from the previous step) in DCM (54 mL) was added TEA (6.69 g, 66.15 mmol, 3.0 equiv.). After 3 min, O,N- dimethylhydroxylamine HC1 (2.37 g, 24.26 mmol, 1.1 equiv.) in DCM (lOmL) was added dropwise to the solution at 0 °C . The reaction mixture was stirred at RT for 1 hour during which a yellow precipitate formed. The reaction mixture was quenched with water and extracted with DCM. The combined organic layers were dried over ISfeSCU and concentrated under reduced pressure. The residue was purified by flash column chromatograohy (silica gel, 40% EtOAc in PE) to yield 2,5,6-trichloro-N-methoxy-N-methyl-pyridine-3-carboxamide (5.7 g, 21.15 mmol, 95.9% yield) as off-white solid. LC-MS: m/z = 269.0 [M+H] ⁺ , ESI pos. Step 3: l-(2,5,6-trichloro-3-pyridyl)ethanone

2,5,6-trichloro-N-methoxy-N-methyl-pyridine-3-carboxamide (5.7 g, 21.15 mmol, 1.0 equiv.) was dissolved in THF (60 mL). MeMgBr (21.2 mL, 63.45 mmol, 3.0 equiv.) was added dropwise at 0 °C under nitrogen atmosphere. After several minustes, an orange solid recipitated. The mixture was stirred for another 2 h at 0 °C. The reaction mixture was then quenched withwater and extracted withEtOAc. The combined organic layers were dried over Na2SO4 and concentrated under reduced pressure. The residue was purified by flash column chromatography (silica gel, 16 - 25% EtOAc in PE) to yield l-(2,5,6-trichloro-3-pyridyl)ethanone (4.5 g, 20.05 mmol, 94.8% yield) as colorless oil. LC-MS: m/z = 223.9 [M-H]’, ESI neg. 'HNMR (400 MHz, CDC1 ₃ ) 8 = 8.05 (s, 1H), 2.73 (s, 3H).

Step 4: l-[ 2, 5-dichloro-6-[5-[ ( 6-methylpyridazin-3-yl)amino ]benzimidazol-l-yl -3- pyridyl ethanone

To a solution of l-(2,5,6-trichloro-3-pyridyl)ethanone (2.0 g, 8.91 mmol, 1.0 equiv.) in DMSO (20 mL) were added N-(6-methylpyridazin-3-yl)-lH-benzimidazol-5-amine (2.01 g, 8.91 mmol, 1.0 equiv., prepared in example 64, intermediate 1) and DIPEA (3.11 mL, 17.82 mmol, 2.0 equiv.). The reaction mixture was stirred at 100 °C for 16 h. The reaction mixture was added into water which lead to the formation of a black precipitate. The filter cake was purified by flash column chromatography (silica gel, 10% MeOH in DCM) which led to the separation of the two regioisomeric products. Further purification by preparative NPLC (Welch Ultimate XB-SiOH 250 mm x 70 mm x 10 pm, gradient 25 - 65% EtOH (with 0.1% ammonium hydroxide) in heptane over 15 min, then 100% EtOH (with 0.1% ammonium hydroxide) (3 min), flow rate 140 mL/min) to give l-[2,5-dichloro-6-[5-[(6-methylpyridazin-3-yl)amino]benzimid azol-l-yl]-3- pyridyl] ethanone (800 mg, 1.94 mmol, 21.7% yield) as abrown gum. LC-MS: m/z = 413.2 [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, DMSO-t/ ₆ ) 6 = 8.99 (s, 1H), 8.51 (s, 1H), 8.45 (s, 1H), 8.20 (d, J= 1.8 Hz, 1H), 7.36 - 7.32 (m, 1H), 7.29 - 7.25 (m, 1H), 7.10 (d, J= 9.0 Hz, 1H), 6.85 (d, J= 9.1 Hz, 1H), 2.48 (s, 3H), 2.25 (s, 3H).

Step 5: l-[ 3-acetyl-5-chloro-6-[5-[ ( 6-methylpyridazin-3-yl)amino ]benzimidazol-l-yl -2- pyridyl]pyrazole-3-carbonitrile

A solution of l-[2,5-dichloro-6-[5-[(6-methylpyridazin-3-yl)amino]benzimid azol-l-yl]-3- pyridyl] ethanone (100.0 mg, 0.240 mmol, 1.0 equiv.), lH-pyrazole-3-carbonitrile (22.53 mg, 0.240 mmol, 1.0 equiv.) and DIPEA (62.55 mg, 0.480 mmol, 2 equiv.) in DMSO (2 mL) was stirred at 100 °C for 16 h. The reaction mixture was poured into water under stirring, and a precipitate formed. The reaction mixture was filtered, the filter cake was dried under reduced pressure to give l-[3-acetyl-5-chloro-6-[5-[(6-methylpyridazin-3-yl)amino]ben zimidazol-l-yl]-2- pyridyl]pyrazole-3 -carbonitrile (80 mg, 0.170 mmol, 70.4% yield) as yellow solid. LC-MS: m/z = 470.2 [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, DMSO-t/ ₆ ) 8 = 9.21 (s, 1H), 8.79 (d, J = 2.7 Hz, 1H), 8.72 (s, 1H), 8.69 (s, 1H), 8.42 (d, J= 1.8 Hz, 1H), 7.65 (d, J= 8.8 Hz, 1H), 7.52 (dd, J = 2.0, 8.8 Hz, 1H), 7.35 - 7.31 (m, 2H), 7.08 (d, J= 9.0 Hz, 1H), 2.48 (s, 6H).

Step 6: l-[5-chloro-3-( 1 -hydroxyethyl)-6-[5-[ ( 6-methylpyridazin-3-yl)amino ]benzimidazol-l- y I] -2 -pyridyl ]pyrazole-3-carbonitrile

Prepared according to example 53, step 4 using l-[3-acetyl-5-chloro-6-[5-[(6-methylpyridazin-3- yl)amino]benzimidazol-l-yl]-2-pyridyl]pyrazole-3-carbonitril e (100.0 mg, 0.210 mmol, 1.0 equiv.) and NaBH4 (25.0 mg, 0.660 mmol, 3.1 equiv.) in MeOH/DCM (1 : 1) to afford l-[5- chloro-3-(l-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amin o]benzimidazol-l-yl]-2- pyridyl]pyrazole-3 -carbonitrile (29 mg, 0.060 mmol, 28% yield) as white solid. LC-MS: m/z = 472.1[M+H] ⁺ , ESI pos. 'H NMR (400 MHz, DMSO-t/ ₆ ) 5 = 9.18 (s, 1H), 8.72 - 8.67 (m, 2H), 8.62 (s, 1H), 8.40 (s, 1H), 7.59 - 7.54 (m, 1H), 7.52 - 7.47 (m, 1H), 7.36 - 7.30 (m, 2H), 7.07 (d, J = 9.0 Hz, 1H), 5.77 - 5.74 (m, 1H), 5.35 - 5.25 (m, 1H), 2.48 (br s, 3H), 1.37 (d, J= 6.4 Hz, 3H).

Example 240

1- [6- [5- [(6-Methylpyridazin-3-yl)amino] benzimidazol- 1-yl] -2- [5-methyl- 1-(2,2,2- trifluoroethyl)pyrazol-4-yl]-3-pyridyl] ethanol; formic acid

Step 1 : l-[ 6-[5-[ ( 6-methylpyridazin-3-yl)amino ] benzimidazol- 1-yl ]-2-[ 3-methyl-l-(2, 2, 2- trijluoroethyl)pyrazol-4-yl]-3-pyridyl ethanone

Prepared in analogy to example 143, step 2 using 3-methyl-4-(4,4,5,5-tetramethyl-l,3,2- dioxaborolan-2-yl)-l-(2,2,2-trifluoroethyl)pyrazole (574.33 mg, 1.98 mmol, 1.5 equiv., prepared in example 143, step 2) and l-[2-chloro-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol -l- yl]-3-pyridyl]ethanone (500.0 mg, 1.32 mmol, 1.0 equiv., prepared in example 76, step 2) to yield 1 -[6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-l -yl]-2-[3-methyl-l -(2,2,2- trifluoroethyl)pyrazol-4-yl]-3-pyridyl]ethanone (200 mg, 0.39 mmol, 29.9% yield) as yellow solid. LC-MS: m/z = 507.1 [M+H] ⁺ , ESI pos. Separation by SFC (Chiralpak AD-3 50 mm x 4.6 mm, 3 pm, 40% 'PrOH+CHsCN (with 0.05% Et2NH) in scCCE, flow rate 3 mL/min, back pressure 100 bar) yielded l-[6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-l-yl]-2- [5- methyl-l-(2,2,2-trifluoroethyl)pyrazol-4-yl]-3-pyridyl]ethan one (650 mg, 1.28 mmol, 28.5% yield) as yellow solid. LC-MS: m/z = 507.1 [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, CD3OD) 5 = 8.92 (s, 1H), 8.39 - 8.17 (m, 3H), 7.97 (s, 1H), 7.87 (d, J= 8.4 Hz, 1H), 7.68 - 7.57 (m, 1H), 7.35 (d, J= 92 Hz, 1H), 7.13 (d, J= 92 Hz, 1H), 5.01 - 4.94 (m, 2H), 2.53 (s, 3H), 2.39 (s, 3H), 2.36 (s, 3H).

Step 2: l-[ 6-[5-[ ( 6-methylpyridazin-3-yl)amino ]benzimidazol-l-yl ]-2-[5-methyl-l-(2, 2, 2- trijluoroethyl)pyrazol-4-yl]-3-pyridyl ethanol; formic acid o

HO—

Prepared in analogy to example 53, step 4 using l-[6-[5-[(6-methylpyridazin-3- yl)amino]benzimidazol-l-yl]-2-[5-methyl-l-(2,2,2-trifluoroet hyl)pyrazol-4-yl]-3- pyridyl] ethanone (30.0 mg, 0.060 mmol, 1.0 equiv.) and NaBIH (11.26 mg, 0.300 mmol, 5.0 equiv.) at -70 °to yield formic acid;l-[6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-l-y l]- 2-[5-methyl-l-(2,2,2-trifluoroethyl)pyrazol-4-yl]-3-pyridyl] ethanol (11.9 mg, 0.020 mmol, 38.09% yield) as yellow solid. LC-MS: m/z = 509.1 [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, CD ₃ OD) 5 = 8.83 (s, 1H), 8.30 (d, J= 8.4 Hz, 1H), 8.22 - 8.14 (m, 2H), 8.14 (s, 1H), 7.84 (d, J= 8.4 Hz, 1H), 7.81 (s, 1H), 7.63 - 7.51 (m, 1H), 7.38 (d, J= 92 Hz, 1H), 7.16 (d, J= 92 Hz, 1H), 5.09 - 5.02 (m, 2H), 2.53 (s, 3H), 2.45 (s, 3H), 1.46 (d, J= 6.4 Hz, 3H).

Example 241 l-[6-[5-[(6-Chloro-4-methoxy-pyridazin-3-yl)amino]benzimidaz ol-l-yl]-3-(l-hydroxyethyl)- 2-pyridyl]-5-methyl-pyrazole-3-carbonitrile Step 1: 6-chloro-4-methoxypyridazin-3-amine

To a stirred, brown slurry of 4-bromo-6-chloropyridazin-3-amine (6.888 g, 33.0 mmol, 1.0 equiv.) in MeOH (100 ml) under an argon atmosphere was added dropwise a 5.4M solution NaOMe in MeOH (7.34 ml, 39.7 mmol, 1.2 equiv.) diluted in MeOH (65 ml). Upon completion of the addition, stirring at RT was continued overnight. The dark brown slurry was concentrated and the residual dark brown solid was purified by flash column chromatography (silica gel, 0 - 5% MeOH in DCM) to yield the title compound (2.91 g, 55.1% yield) as a brown solid. LC-MS: m/z = 160.1 [M+H] ⁺ , ESI pos.

Step 2: l-[ 3-acetyl-6-[5-[ ( 6-chloro-4-methoxy-pyridazin-3-yl)amino ]benzimidazol-l-yl ]-2- pyridyl]-5-methyl-pyrazole-3-carbonitrile

Prepared in analogy to example 104, step 2 using l-[3-acetyl-6-(5-bromobenzimidazol-l-yl)-2- pyridyl]-5-methyl-pyrazole-3-carbonitrile (30 mg, 0.071 mmol, 1 equiv., prepared in example 65, step 1), (6-chloro-4-methoxy-pyridazin-3-yl)amine (22.73 mg, 0.142 mmol, 2.0 equiv.) and two additions of [tBuBrettPhos Pd(allyl)]OTf (5.56 mg, 0.007 mmol, 0.100 equiv.) in an interval of 2 h to yield the title compound (15.9 mg, 35.7% yield) as a yellow solid. LC-MS: m/z = 492.3 [M+H] ⁺ , ESI pos.

Step 3: l-[ 6-[5-[ ( 6-chloro-4-methoxy-pyridazin-3-yl)amino ]benzimidazol-l-yl ]-3-( 1 - hydroxyethyl)-2-pyridyl]-5-methyl-pyrazole-3-carbonitrile Prepared in analogy to example 53, step 4 using l-[3-acetyl-6-[5-[(6-chloro-4-methoxy- pyridazin-3-yl)amino]benzimidazol-l-yl]-2-pyridyl]-5-methyl- pyrazole-3-carbonitrile (17.3 mg, 0.033 mmol, 1 equiv.) and NaBH4 (7.5 mg, 0.2 mmol, 6.0 equiv.) in MeOH/THF (1 : 1) to yield the title compound (9 mg, 52.9% yield) as a light yellow solid. LC-MS: m/z = 502.3 [M+H] ⁺ , ESI pos.

Example 242

(3R,5S)-1- [3-(l-hydroxyethyl)-6- [5- [(6-methylpyridazin-3-yl)amino] benzimidazol-l-yl]-2- pyridyl]-5-methyl-pyrrolidine-3-carbonitrile; formic acid

Step 1: tert-butyl (2S,4S)-2-methyl-4-methylsulfonyloxy-pyrrolidine-l-carboxyla te

To a solution of tert-butyl (2R,4R)-4-hydroxy-2-methyl-pyrrolidine-l -carboxylate (1.0 g, 4.97 mmol, 1.0 equiv.) and TEA (2.5 g, 24.9 mmol, 5.0 equiv.) in DCM (10 mL) was added MsCl (0.78 mL, 9.95 mmol, 2.0 equiv.) dropwise at 0°C. The reaction mixture was stirred at 0 °C for 3 h. TLC (PE/EA=1/1, ninhydrin) showed tert-butyl (2R,4R)-4-hydroxy-2-methyl-pyrrolidine-l- carboxylate was consumed completely and a new spot was formed. The mixture was diluted with water and extracted with DCM. The combined organic layers were washed with brine, dried over Na2SO4 and the volatiles evaporated. The residue was purified by flash column chromatograohy (10 - 50% EtOAc in PE) to yield tert-butyl rac-(2R,4R)-2-methyl-4-methylsulfonyl oxypyrrolidine-1 -carboxylate (1410 mg, 5.05 mmol, 96.5% yield) as a yellow oil. ^J H NMR (400 MHz, CDCh) 6 = 5.21 - 5.15 (m, 1H), 4.06 - 3.71 (m, 2H), 3.56 (br d, J = 10.4 Hz, 1H), 3.03 (s, 3H), 2.45 (br d, J = 1.6 Hz, 1H), 1.90 - 1.81 (m, 1H), 1.47 (s, 9H), 1.30 - 1.26 (m, 3H). Step 2: tert-butyl (2S,4R)-4-cyano-2-methyl-pyrrolidine-l-carboxylate

To a mixture of tert-butyl (2S,4S)-2-methyl-4-methylsulfonyloxy-pyrrolidine-l-carboxyla te (1.4 g, 5.0 mmol, 1.0 equiv.) in DMSO (15 mL) was added sodium cyanide (0.98 g, 20.0 mmol, 4.0 equiv.). The mixture was stirred at 80 °C for 16 h. The mixture was poured into aq. sat. NaHCOs and extracted with EtOAc. The combined organic layers were washed with brine, dried over Na2SO4 and the volatiles evaporated. The residue was purified by column chromatography (10 - 50% EtOAc in PE) to yield tert-butyl (2S,4R)-4-cyano-2-methyl-pyrrolidine-l-carboxylate (805 mg, 3.83 mmol, 72.6% yield) as a colorless oil. LC-MS: m/z = 155.1 [M-56+H] ⁺ ESI pos. 'H NMR (400 MHz, CDC1 ₃ ) 8 = 5.21 - 5.15 (m, 1H), 4.06 - 3.71 (m, 2H), 3.56 (br d, J = 10.4 Hz, 1H), 3.03 (s, 3H), 2.45 (br d, J = 1.7 Hz, 1H), 1.90 - 1.81 (m, 1H), 1.47 (s, 9H), 1.30 - 1.26 (m, 3H).

(NaCN work-up: Aqueous KOH (IM) was added to the combined aqueous phase to pH about 12. Then the mixture was poured into NaClO aqueous(5%, 1500 mL) and standing overnight and detected by analysis department recycled by special recycling bucket.)

Step 3: (3R,5S)-5-methylpyrrolidine-3-carbonitrile;2,2,2-trifluoroac etic acid

To a solution of tert-butyl (2S,4R)-4-cyano-2-methyl-pyrrolidine-l-carboxylate (1.5 g, 7.13 mmol, 1.0 equiv.) in DCM (10 mL) was added TFA (10.0 mL, 123.25 mmol, 17.3 equiv.). The mixture was stirred at 25 °C for 2 h. The mixture was concentrated in vacuo to afford (3R,5S)-5- methylpyrrolidine-3-carbonitrile;2,2,2-trifluoroacetic acid as light brown oil. The crude product was used into next step without further purification. 'H NMR (400 MHz, DMSO- e) 5 = 3.63 - 3.43 (m, 4H), 2.60 - 2.52 (m, 1H), 1.86 - 1.76 (m, 1H), 1.32 (d, J= 6.5 Hz, 3H).

Step 4 : ( 3R, 5S)-l-(3-acetyl-6-chloro-2-pyridyl)-5-methyl-pyrrolidine-3-c arbonitrile A solution of (3R,5S)-5-methylpyrrolidine-3-carbonitrile;2,2,2-trifluoroac etic acid (used as crude from the previous step) and DIPEA (6.18 mL, 37.37 mmol, 5.59 equiv.) in DMSO (20 mL) was stirred at RT for 5 min. Then, l-(6-chloro-2-fluoro-3-pyridyl)ethanone (CAS# 1260663-13-5, 1.22 g, 7.05 mmol, 1.05 equiv., prepared in example 64, step 1) was added, and the reaction mixture stirred for 16 hours at RT. The reaction mixture was quenched with water and extracted with EtOAc. The combined organic layers were dried over ISfeSCU and concentrated under reduced pressure. The residue was purified by flash column chromatography (silica gel, 0 - 25% EtOAc in PE) to give (3R,5S)-l-(3-acetyl-6-chloro-2-pyridyl)-5-methyl-pyrrolidine -3- carbonitrile (1.2 g, 4.55 mmol, 60% yield) as light yellow oil. LC-MS: m/z = 264.0 [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, CDCI3) 8 = 7.84 (d, J = 8.0 Hz, 1H), 6.74 (d, J= 8.1 Hz, 1H), 4.48 - 4.39 (m, 1H), 3.75 (t, J= 10.7 Hz, 1H), 3.06 - 2.97 (m, 1H), 2.95 - 2.84 (m, 1H), 2.67 - 2.59 (m, 1H), 2.55 (s, 3H), 2.03 - 1.96 (m, 1H), 1.36 (d, J= 6.0 Hz, 3H).

Step 5: mixture of (3R,5S)-l-[3-acetyl-6-[5-[(6-methylpyridazin-3-yl)amino]benz imidazol-l-yl]- 2 -pyridyl ]-5-methyl-pyrrolidine-3-carbonitrile and ( 3R, 5S)-l-[ 3-acetyl-6-[ 6-[ ( 6- methylpyridazin-3-yl)amino] benzimidazol-1 -yl] -2-pyridyl] -5-methyl-pyrrolidine-3-carbonitrile

Prepared in analogy to example 64, step 2 using (3R,5S)-l-(3-acetyl-6-chloro-2-pyridyl)-5- methyl-pyrrolidine-3-carbonitrile (1.20 g, 4.6 mmol, 1.0 equiv.), N-(6-methylpyridazin-3-yl)-lH- benzimidazol-5-amine (1.32 g, 5.0 mmol, 1.1 equiv., prepared in example 64, intermediate 1) and K2CO3 (1.92 g, 13.9 mmol, 3.05 equiv.) Purification by preparative HPLC (Phenomenex Luna C18 250 mm x 50 mm x 10 pm, gradient 5 - 40% CH3CN in H2O (with 0.1% TFA) over 20 min, then 100% CH3CN (2 min), flow rate 100 mL/min) to yield (3R,5S)-l-[3-acetyl-6-[5- [(6-methylpyridazin-3-yl)amino]benzimidazol-l-yl]-2-pyridyl] -5-methyl-pyrrolidine-3- carbonitrile (450 mg, 0.990 mmol, 21.9% yield) and (3R,5S)-l-[3-acetyl-6-[6-[(6- methylpyridazin-3-yl)amino]benzimidazol-l-yl]-2-pyridyl]-5-m ethyl-pyrrolidine-3-carbonitrile (800 mg, 1.760 mmol, 38.9 % yield) as light-brown solids. Regioisomer 1 : LC-MS: m/z = 453.2 [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, CD3OD) 5 = 9.05 (s, 1H), 8.38 (dd, J = 3.0, 8.6 Hz, 2H), 8.22 (d, J = 1.8 Hz, 1H), 7.91 (d, J = 9.4 Hz, 1H), 7.73 (d, J = 9.4 Hz, 1H), 7.55 (dd, J = 2.1, 8.9 Hz, 1H), 7.27 (d, J = 8.3 Hz, 1H), 4.68 - 4.58 (m, 1H), 3.73 (s, 1H), 3.24 - 3.15 (m, 2H), 2.76 (td, J = 7.2, 12.5 Hz, 1H), 2.68 - 2.65 (m, 6H), 2.11 - 1.98 (m, 1H), 1.44 (d, J = 6.1 Hz, 3H).

Regioisomer 2: LC-MS: m/z = 453.2 [M+H] ⁺ , ESI pos.

Step 6: ( 3R, 5S)-l-[ 3-(l -hydroxyethyl)-6-[5-[ ( 6-methylpyridazin-3-yl)amino ]benzimidazol-l-yl ]- 2 -pyridyl ]-5-methyl-pyrrolidine-3-carbonitrile; formic acid

Prepared in analogy to example 53, step 4 using (3R,5S)-l-[3-acetyl-6-[5-[(6-methylpyridazin-3- yl)amino]benzimidazol-l-yl]-2-pyridyl]-5-methyl-pyrrolidine- 3-carbonitrile (450 mg, 1.0 mmol, 1.0 equiv.) and NaBIH (113 mg, 3.0 mmol, 3.0 equiv.) at 20 °C to yield (3R,5S)-l-[3-(l- hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidaz ol-l-yl]-2-pyridyl]-5-methyl- pyrrolidine-3 -carbonitrile; formic acid (91.4 mg, 0.180 mmol, 17.1 % yield) as a yellow solid after preparative HPLC (Phenomenex C18 150 mm x 25 mm x 10 pm, gradient 10 - 4 % CH3CN in H2O (with 0.225% formic acid) over 10 min, then 100% CH3CN (2 min), flow rate 25 mL/min). LC-MS: m/z = 455.2 [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, CD3OD) 5 = 8.78 (br s, 1H), 8.36 - 8.25 (m, 1H), 8.24 - 8.04 (m, 3H), 7.63 (br d, J = 8.9 Hz, 1H), 7.48 - 7.35 (m, 2H), 7.20 - 7.13 (m, 1H), 5.24 - 5.15 (m, 1H), 4.47 - 4.39 (m, 1H), 4.00 - 3.87 (m, 1H), 3.78 - 3.67 (m, 1H), 3.26 - 3.14 (m, 1H), 2.75 - 2.67 (m, 1H), 2.60 - 2.53 (m, 3H), 2.06 - 1.94 (m, 1H), 1.64 (br d, J = 6.4 Hz, 2H), 1.52 - 1.42 (m, 1H), 1.35 - 1.25 (m, 3H) .

Example 245

1- [5-Chloro-3-(l-hydroxyethyl)-6- [5- [(6-methylpyridazin-3-yl)amino] benzimidazol-l-yl]-2- pyridyl]-5-methyl-pyrazole-3-carbonitrile; formic acid

Step 1: l-[3-acetyl-5-chloro-6-[5-[(6-methylpyridazin-3-yl)amino]ben zimidazol-l-yl]-2- pyridyl ]-5-methyl-pyrazole-3-carbonitrile

Prepared in analogy to example 239, step 2 using l-[2,5-dichloro-6-[5-[(6-methylpyridazin-3- yl)amino]benzimidazol-l-yl]-3-pyridyl]ethanone (350.0 mg, 0.850 mmol, 1.0 equiv., prepared in example 239, step 1) and 5-methyl-lH-pyrazole-3-carbonitrile (90.71 mg, 0.850 mmol, 1.0 equiv.) to yield l-[3-acetyl-5-chloro-6-[5-[(6-methylpyridazin-3-yl)amino]ben zimidazol-l-yl]-2- pyridyl]-5-methyl-pyrazole-3-carbonitrile (40 mg, 0.080 mmol, 9.8% yield) as yellow solid. LC- MS: m/z = 484.1 [M+H] ⁺ , ESI pos. 'HNMR (400 MHz, CD ₃ OD) 5 = 8.70 (s, 1H), 8.64 (s, 1H), 8.27 (s, 1H), 7.63 - 7.61 (m, 2H), 7.38 (d, J= 9.1 Hz, 1H), 7.15 (d, J= 9.1 Hz, 1H), 6.87 (s, 1H), 2.58 (s, 3H), 2.55 (s, 3H), 2.35 (s, 3H). Step 2: l-[5-chloro-3-( 1 -hydroxyethyl)-6-[5-[ ( 6-methylpyridazin-3-yl)amino ]benzimidazol-l- y I] -2 -pyridyl ]-5-methyl-pyrazole-3-carbonitrile; formic acid

Prepared in analogy to example 53, step 4 using l-[3-acetyl-5-chloro-6-[5-[(6-methylpyridazin- 3-yl)amino]benzimidazol-l-yl]-2-pyridyl]-5-methyl-pyrazole-3 -carbonitrile (20.0 mg, 0.040 mmol, 1.0 equiv.) and NaBELj (4.69 mg, 0.120 mmol, 3.0 equiv.) to yield l-[5-chloro-3-(l- hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidaz ol-l-yl]-2-pyridyl]-5-methyl- pyrazole-3 -carbonitrile; formic acid (11.3 mg, 0.020 mmol, 56.3% yield) as yellow solid. LC- MS: m/z = 486.2 [M+H] ⁺ , ESI pos. 'HNMR (400 MHz, CD ₃ OD) 5 = 8.64 (s, 1H), 8.62 (s, 1H), 8.30 (br s, 1H), 8.24 (d, J= 1.8 Hz, 1H), 7.59 (dd, J= 2.0, 8.9 Hz, 1H), 7.52 - 7.47 (m, 1H), 7.38 (d, J= 9.3 Hz, 1H), 7.15 (d, J= 9.1 Hz, 1H), 6.84 (d, J= 0.8 Hz, 1H), 4.94 (s, 1H), 2.55 (s, 3H), 2.40 (d, J= 0.6 Hz, 3H), 1.42 (d, J= 6.4 Hz, 3H).

Example 246

5- [3-(l-Hydroxyethyl)-6- [5- [(6-methylpyridazin-3-yl)amino] benzimidazol-l-yl]-2-pyridyl]- 2-methyl-pyrazole-3-carbonitrile; formic acid Step 1: 5-bromo-2-methyl-pyrazole-3-carbonitrile

To a solution of 5-bromo-2-methyl-pyrazole-3-carboxamide (500.0 mg, 2.45 mmol, 1.0 equiv.) and TEA (1.02 mL, 7.35 mmol, 3 equiv.) in DCM (10 mL), was added TFAA (0.41 mL, 2.94 mmol, 1.2 equiv.) slowly at 0 °C, and the reaction was stirred at 30 °C for 12 h. The mixture was poured into water. The aqueous phase was extracted with EtOAc). The combined organic layers were washed with, dried over anhydrous Na2SO4 and concentrated under reduced pressure. The residue was purified by flash column chromatography (silica gel, 5% EtOAc in DCM) to afford 5-bromo-2-methyl-pyrazole-3-carbonitrile (400 mg, 2.15 mmol, 86.0% yield) as a white solid. 'HNMR (400 MHz, CDCI3) 8 = 6.77 - 6.83 (m, 1 H) 4.04 - 4.09 (m, 3 H).

Step 2: 2-methyl-5-(4, 4, 5,5-tetramethyl-l, 3, 2-dioxaborolan-2-yl)pyrazole-3-carbonitrile

Prepared in analogy to example 143, step 2 using 5 -bromo-2-methyl-pyrazole-3 -carbonitrile (100.0 mg, 0.540 mmol, 1.0 equiv.) and 5 -bromo-2-methyl-pyrazole-3 -carbonitrile (100.0 mg, 0.540 mmol, 1.0 equiv.) to yield 2 -methyl-5-(4, 4, 5,5-tetramethyl-l, 3, 2-dioxaborolan-2- yl)pyrazole-3 -carbonitrile (100 mg, 0.430 mmol, 76.62% yield) a brown solid after purification by preparative TLC (25% EtOAc in PE). 'H NMR (400 MHz, CDC1 ₃ ) 5 = 7.15 - 7.17 (m, 1 H) 2.05 (s, 3 H) 1.35 - 1.37 (m, 12 H).

Step 3: 5-[ 3-acetyl-6-[5-[ ( 6-methylpyridazin-3-yl)amino ]benzimidazol-l-yl ]-2-pyridyl ]-2- methyl-pyrazole-3-carbonitrile

Prepared in analogy to example 143, step 2 using l-[2-chloro-6-[5-[(6-methylpyridazin-3- yl)amino]benzimidazol-l-yl]-3-pyridyl]ethanone (50.0 mg, 0.130 mmol, 1.0 equiv., prepared in example 65, step l)and 2-methyl-5-(4, 4, 5,5-tetramethyl-l, 3, 2-dioxaborolan-2-yl)pyrazole-3- carbonitrile (46.14 mg, 0.200 mmol, 1.5 equiv.) to give 5-[3-acetyl-6-[5-[(6-methylpyridazin-3- yl)amino]benzimidazol-l-yl]-2-pyridyl]-2-methyl-pyrazole-3-c arbonitrile (15 mg, 0.030 mmol, 24.3% yield) as a white solid. LC-MS: m/z = 450. 2 [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, DMSO-tfc) 6 ppm 9.22 - 9.26 (m, 1 H) 9.07 - 9.12 (m, 1 H) 8.34 - 8.42 (m, 2 H) 8.11 - 8.15 (m, 1 H) 8.05 - 8.08 (m, 1 H) 7.60 - 7.64 (m, 1 H) 7.32 - 7.37 (m, 1 H) 7.08 - 7.14 (m, 1 H) 4.10 - 4.13 (m, 3 H) 2.41 - 2.43 (m, 3 H). Step 4:5-[ 3-( 1 -hydroxyethyl)-6-[5-[ ( 6-methylpyridazin-3-yl)amino ]benzimidazol-l-yl ]-2- pyridyl]-2-methyl-pyrazole-3-carbonitrile;

Prepared in analogy to example 53, step 4 using 5-[3-acetyl-6-[5-[(6-methylpyridazin-3- yl)amino]benzimidazol-l-yl]-2-pyridyl]-2-methyl-pyrazole-3-c arbonitrile (15.0 mg, 0.030 mmol, 1.0 equiv.) to give 5-[3-(l-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino]be nzimidazol-l- yl]-2-pyridyl]-2-methyl-pyrazole-3-carbonitrile; formic acid (4 mg, 0.010 mmol, 26.4% yield) as a white solid. LC-MS: m/z = 452.1 [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, CD ₃ OD) 5 ppm 8.82 - 8.88 (m, 1 H) 8.33 - 8.38 (m, 1 H) 8.14 - 8.23 (m, 2 H) 7.79 - 7.83 (m, 1 H) 7.60 - 7.65 (m, 1 H) 7.52 - 7.56 (m, 1 H) 7.35 - 7.41 (m, 1 H) 7.13 - 7.19 (m, 1 H) 5.78 - 5.86 (m, 1 H) 4.14 - 4.20 (m, 3 H) 2.53 - 2.59 (m, 3 H) 1.51 - 1.57 (m, 3 H).

Example 247 l-[3-[(lR)-l-hydroxyethyl]-6-[6-[(6-methylpyridazin-3-yl)ami no]benzimidazol-l-yl]-2- pyridyl]-5-methyl-pyrazole-3-carbonitrile l-[3-(l-hydroxyethyl)-6-[6-[(6-methylpyridazin-3-yl)amino]be nzimidazol-l-yl]-2-pyridyl]-5- methyl-pyrazole-3 -carbonitrile (obtained as in step 3 of example 64) (400 mg, 0.89 mmol, 1 equiv.) was purified by chiral SFC (Daicel Chiralpak AY-H (250mm x 30mm x 10pm). Flow rate: 70 mL / min. 60% (0.1% NH4OH in isopropanol)). The title compound (124.2 mg, 0.275 mmol, 30.9 % yield) was obtained as a white solid. LC-MS: m/z = 452.2 [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, CD3OD): 5 = 8.89 (s, 1H), 8.50 (d, J = 8.4 Hz, 1H), 8.22 (d, J = 2.0 Hz, 1H), 8.16 - 8.08 (m, 2H), 7.59 (dd, J= 2.1, 8.9 Hz, 1H), 7.35 (d, J= 9.3 Hz, 1H), 7.12 (d, J= 9.1 Hz, 1H), 6.87 (s, 1H), 4.79 - 4.74 (m, 1H), 2.53 (s, 3H), 2.41 (s, 3H), 1.41 (d, J = 6.5 Hz, 3H). Assignment of the absolute stereochemistry was done in analogy to examples 109 and 110.

Example 248 l-[2-[3,5-Bis(difluoromethyl)pyrazol-l-yl]-6-[5-[(6-methylpy ridazin-3- yl)amino]benzimidazol-l-yl]-3-pyridyl]ethanol

Step 1 : l-[ 2-fluoro-6-[5-[ ( 6-methylpyridazin-3-yl)amino ]benzimidazol-l-yl ]-3-pyridyl ] ethanone lH-benzimidazol-5-yl-(6-methylpyridazin-3-yl)amine (4.05 g, 15.27 mmol, 1.2 equiv.) and K2CO3 (3.52 g, 25.46 mmol, 2.0 equiv.) were suspended in DMF (65 mL) and cooled to - 20 °C. l-(2,6-difluoro-3-pyridyl)ethanone (2.0 g, 1.45 mL, 12.73 mmol, 1.0 equiv.) was added dropwise and the reaction allowed to stir for 3 h. The reaction was allowed to warm to rt, water and DCM were added which resulted in the formation of a suspension. The mixture was filtered. The filter cake was dissolved in DMF and reprecipitated on ice. After filtration, the filter cake is adsorbed on isolute, and purified by column chromatography (silica gel, 5 - 50% MeOH/NH-tOH (9:1) in MeOH to yield l-[2-fluoro-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol -l-yl]-3- pyridyl] ethanone (1.71 g, 34.4%) as yellow solid. LC-MS: m/z = 363.2 [M+H] ⁺ , ESI pos. Step 2: l-[2-[ 3, 5-bis(difluoromethyl)pyrazol-l-yl ]-6-[5-[ ( 6-methylpyridazin-3- yl)amino ]benzimidazol-l-yl ]-3-pyridyl ethanone l-[2-fluoro-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol -l-yl]-3-pyridyl]ethanone (30 mg, 0.083 mmol, 1.0 equiv.,) was dissolved in DMF (1 mL) and 3,5-bis(difluoromethyl)-lH-pyrazole (15.31 mg, 0.091 mmol, 1.1 equiv.) and K2CO3 (17.16 mg, 0.124 mmol, 1.5 equiv.) were added at rt. The mixture was stirred for 5 h at rt. LC-MS showed reaction was finished. The reaction mixture was diluted with water and extracted two times with EtOAc. The organic layers were washed with brine, dried over MgSCU and concentrated to dryness to obtain the crude intermediate l-[2-[3,5-bis(difluoromethyl)pyrazol-l-yl]-6-[5-[(6-methylpy ridazin-3- yl)amino]benzimidazol-l-yl]-3-pyridyl]ethanone as light yellow solid which was used in the next step without further purification.

Step 3: l-[2-[ 3, 5-bis(difluoromethyl)pyrazol-l-yl ]-6-[5-[ ( 6-methylpyridazin-3- yl)amino ]benzimidazol-l-yl ]-3-pyridyl ethanol

Prepared in anaogy to example 53, step 4 using l-[2-[3,5-bis(difluoromethyl)pyrazol-l-yl]-6-[5- [(6-methylpyridazin-3-yl)amino]benzimidazol-l-yl]-3-pyridyl] ethanone (used as crude from the previous step) in 'PrOH/THF (1 : 1) to yield l-[2-[3,5-bis(difhioromethyl)pyrazol-l-yl]-6-[5-[(6- methylpyridazin-3-yl)amino]benzimidazol-l-yl]-3-pyridyl]etha nol (24.5 mg, 57.3%) as light yellow solid. LC-MS: m/z = 513.27 [M+H] ⁺ , ESI pos. Example 249 l-[3-(l-Hydroxyethyl)-6-[5-[[6-(trifluoromethyl)pyridazin-3- yl]amino]benzimidazol-l-yl]-

2-pyridyl]-5-methyl-pyrazole-3-carbonitrile Step 1: l-[3-acetyl-6-[5-[[6-(trifluoromethyl)pyridazin-3-yl]amino]b enzimidazol-l-yl]-2- pyridyl]-5-methyl-pyrazole-3-carbonitrile

Prepared in analogy to example 104, step 2 using l-[3-acetyl-6-(5-bromobenzimidazol-l-yl)-2- pyridyl]-5-methyl-pyrazole-3-carbonitrile (30 mg, 0.071 mmol, 1.0 equiv., prepared in example 65, step 1) and [6-(trifluoromethyl)pyridazin-3-yl]amine (23.23 mg, 0.142 mmol, 2.0 equiv.) to yield the title compound (23.4 mg, 58.7% yield) as a light yellow solid. LC-MS: m/z = 504.3 [M+H] ⁺ , ESI pos.

Step 2: l-[3-(l-hydroxyethyl)-6-[5-[[6-(trifluoromethyl)pyridazin-3- yl]amino]benzimidazol-l- y I] -2 -pyridyl ]-5-methyl-pyrazole-3-carbonitrile Prepared in analogy to example 53, step 4 using l-[3-acetyl-6-[5-[[6-(trifluoromethyl)pyridazin- 3-yl]amino]benzimidazol-l-yl]-2-pyridyl]-5-methyl-pyrazole-3 -carbonitrile (23.4 mg, 0.046 mmol, 1 equiv.) in MeOH/THF (1 : 1) to yield the title compound (22.2 mg, 91.7% yield) as light yellow solid. LC-MS: m/z = 506.3 [M+H] ⁺ , ESI pos.

Example 250

1- [2- [2-Ethyl-5-(trifluoromethyl)pyrazol-3-yl] -6- [5- [(6-methylpyridazin-3- yl)amino]benzimidazol-l-yl]-3-pyridyl]ethanol

Step J: 5-bromo-l-ethyl-3-(trifluoromethyl)pyr azole

To a solution of 5-bromo-3-(trifluoromethyl)-lH-pyrazole (500.0 mg, 2.33 mmol, 1.0 equiv.) in 1,4-dioxane (10 mL) was added iodoethane (0.28 mL, 3.49 mmol, 1.5 equiv.) and K2CO3 (0.96 g, 6.98 mmol, 3.0 equiv.). The reaction mixture was stirred at 100 °C for 12 h. The mixture was cooled to RT and filtered. The filtrate was used without further purification in the next step. LC- MS: m/z = 245.0 [M+H] ⁺ , ESI pos.

Step 2: l-ethyl-5-(4, 4, 5,5-tetramethyl-l, 3, 2-dioxaborolan-2-yl)-3-(trifluoromethyl)pyrazole

Prepared in analogy to example 109, step 3 using 5-bromo-l-ethyl-3-(trifluoromethyl)pyrazole used as crude from the previous step) and bis(pinacolato)diboron (783 mg, 3.100 mmol, 1.5 equiv.). After the reaction was completed, the mixture was cooled to RT and filtered. The filtrate was evaporated to dryness to yield l-ethyl-5-(4, 4, 5,5-tetramethyl-l, 3, 2-dioxaborolan-2-yl)-3- (trifluoromethyl)pyrazole (153.2 mg, 0.530 mmol, 22.7% yield over 2 steps) as brown liquid which was used in next step without further purification. LC-MS: m/z = 327.0 [M+H] ⁺ , ESI pos.

Step 3: l-[ 2-[ 2-ethyl-5-(trifluoromethyl)pyrazol-3-yl ]-6-[5-[ ( 6-methylpyridazin-3- yl)amino ]benzimidazol-l-yl ]-3-pyridyl ethanone

Prepared in analogy to example 143, step 2 using l-ethyl-5-(4,4,5,5-tetramethyl-l,3,2- dioxaborolan-2-yl)-3-(trifluoromethyl)pyrazole (153.2 mg, 0.530 mmol, 2.0 equiv.) and l-[2- chloro-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-l-yl ]-3-pyridyl]ethanone (100.0 mg, 0.260 mmol, 1.0 equiv., prepared in example 76, step 2) to yield l-[2-[2-ethyl-5- (trifluoromethyl)pyrazol-3-yl]-6-[5-[(6-methylpyridazin-3-yl )amino]benzimidazol-l-yl]-3- pyridyl] ethanone (10 mg, 0.020 mmol, 7.1% yield). LC-MS: m/z = 509.0 [M+H] ⁺ , ESI pos.

Step 4: l-[ 2-[ 2-ethyl-5-(trifluoromethyl)pyrazol-3-yl ]-6-[5-[ ( 6-methylpyridazin-3- yl)amino ]benzimidazol-l-yl ]-3-pyridyl ethanol

Prepared in analogy to example 53, step 4 using l-[2-[2-ethyl-5-(trifluoromethyl)pyrazol-3-yl]-6- [5-[(6-methylpyridazin-3-yl)amino]benzimidazol-l-yl]-3-pyrid yl]ethanone (10.0 mg, 0.020 mmol, 1.0 equiv.) and NaBEL (1.12 mg, 0.030 mmol, 1.5 equiv.) at - 70 °C to give l-[2-[2- ethyl-5-(trifluoromethyl)pyrazol-3-yl]-6-[5-[(6-methylpyrida zin-3-yl)amino]benzimidazol-l-yl]- 3 -pyridyl] ethanol (3.73 mg, 0.010 mmol, 37.2% yield) as white solid LC-MS: m/z = 509.0 [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, CD ₃ OD) 5 = 8.89 (s, 1H), 8.40 (d, J= 8.6 Hz, 1H), 8.21 (d, J= 1.5 Hz, 1H), 8.14 (d, J = 8.9 Hz, 1H), 8.04 (d, J = 8.7 Hz, 1H), 7.59 - 7.53 (m, 1H), 7.43 (d, J= 92 Hz, 1H), 7.21 (d, J= 92 Hz, 1H), 6.88 (s, 1H), 4.96 - 4.93 (m, 1H), 4.26 (dq, J= 2.0, 7.1 Hz, 2H), 2.55 (s, 3H), 1.45 (d, J= 6.5 Hz, 3H), 1.39 (t, J= 7.2 Hz, 3H).

Example 251 (lR)-l-[6-[5-[(6-Methylpyridazin-3-yl)amino]benzimidazol-l-y l]-2-[3-methyl-l-(2,2,2- trifluoroethyl)pyrazol-4-yl] -3-pyridyl] ethanol

The enantiomers of l-[6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-l-yl]-2- [3-methyl-l- (2,2,2-trifluoroethyl)pyrazol-4-yl]-3-pyridyl]ethanol (450.0 mg, 0.880 mmol, 1.0 equiv., from Example 240, step 2) were separated by chiral SFC (Daicel ChiralPak IG 250 mm x 30 mm, 10 pm, PrOH (with 0.1% ammonium hydroxide) (lR)-l-[6-[5-[(6-methylpyridazin-3- yl)amino]benzimidazol-l-yl]-2-[3-methyl-l-(2,2,2-trifluoroet hyl)pyrazol-4-yl]-3-pyridyl]ethanol (211.9 mg, 0.420 mmol, 47.1% yield, 99.4% ee) as light yellow solid. LC-MS: m/z = 509.2 [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, CD ₃ OD) 5 = 8.83 (s, 1H), 8.28 (d, J= 8.4 Hz, 1H), 8.19 (d, J = 1.6 Hz, 1H), 8.15 (d, J = 8.8 Hz, 1H), 8.01 (s, 1H), 7.83 (d, J = 8.4 Hz, 1H), 7.62 - 7.52 (m, 1H), 7.35 (d, J= 92 Hz, 1H), 7.12 (d, J = 9.2 Hz, 1H), 5.06 - 4.95 (m, 3H), 2.52 (s, 3H), 2.35 (s, 3H), 1.47 (d, J = 6.4 Hz, 3H). Assignment of the absolute stereochemistry was done in analogy to examples 109 and 110.

Example 252

(1 S)- 1- [6- [5- [(6-Methylpyridazin-3-yl)amino] benzimidazol- 1-yl] -2- [3-methyl- 1-(2,2,2- trifluoroethyl)pyrazol-4-yl] -3-pyridyl] ethanol

The enantiomers of l-[6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-l-yl]-2- [3-methyl-l- (2,2,2-trifluoroethyl)pyrazol-4-yl]-3-pyridyl]ethanol (450.0 mg, 0.880 mmol, 1.0 equiv., from Example 240, step 2) were separated by chiral SFC (Daicel ChiralPak IG 250 mm x 30 mm, 10 pm, 'PrOH (with 0.1% ammonium hydroxide)) (lS)-l-[6-[5-[(6-methylpyridazin-3- yl)amino]benzimidazol-l-yl]-2-[3-methyl-l-(2,2,2-trifluoroet hyl)pyrazol-4-yl]-3-pyridyl]ethanol (206.3 mg, 0.410 mmol, 45.8% yield, 100% ee) as light yellow solid. LC-MS: m/z = 509.2 [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, CD ₃ OD) 5 = 8.84 (s, 1H), 8.30 (s, 1H), 8.20 (d, J = 2.0 Hz, 1H), 8.16 (d, J = 8.8 Hz, 1H), 8.02 (s, 1H), 7.84 (d, J = 8.4 Hz, 1H), 7.65 - 7.54 (m, 1H), 7.36 (d, J= 9.2 Hz, 1H), 7.13 (d, J= 9.2 Hz, 1H), 5.09 - 4.98 (m, 3H), 2.53 (s, 3H), 2.35 (s, 3H), 1.47 (d, J = 6.4 Hz, 3H). Assignment of the absolute stereochemistry was done in analogy to examples 109 and 110.

Example 253

1- [3-(l-Hydroxyethyl)-6- [5- [(6-methylpyridazin-3-yl)amino] benzimidazol- 1-yl] -2- pyridyl]triazole-4-carbonitrile Step 1 : 2-[ 3-acetyl-6-[5-[ ( 6-methylpyridazin-3-yl)amino ]benzimidazol-l-yl / -2 -pyridyl Jtriazole- 4-carbonitrile, and l-[ 3-acetyl-6-[5-[ ( 6-methylpyridazin-3-yl)amino ]benzimidazol-l-yl -2- pyridyl triazole-4-carbonitrile, and 3-[ 3-acetyl-6-[5-[ ( 6-methylpyridazin-3- yl)amino ]benzimidazol-l-yl / -2 -pyridyl triazole-4-carbonitrile

A solution of l-[2-chloro-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol -l-yl]-3- pyridyl] ethanone (300.0 mg, 0.790 mmol, 1.0 equiv., prepared in example 76, step 2), 2H- triazole-4-carbonitrile (90.0 mg, 0.960 mmol, 1.21 equiv.) and DIPEA (0.42 mL, 2.55 mmol, 3.22 equiv.) in DMSO (6 mL) was stirred at 100 °C for 12 h. The reaction was poured into water and a dark brown solid was precipitated out. After filtration, the filter cake was dried under reduced pressure. The filtrate was extracted with and the combined organic layers were washed with brine. The organic layer and filter cake were combined and concentrated under vacuum. The residue was purified by preparative NPLC (Welch Ultimate XB-CN 250 mm x 70 mm x 10 pm, gradient 60 - 100% EtOH in hexane over 15 min, then 100% EtOH (2 min), flow rate 140 mL/min) followed by preparative HPLC (Phenom enex Synergi Poar-RP 100 mm x 25mm x 4 pm, gradient 24 - 44% CEECN in H2O (with 0.225% formic acid) over 7 min, then 100% CH3CN (2 min), flow rate 25 mL/min, 1 injection) to afford 2-[3-acetyl-6-[5-[(6- methylpyridazin-3-yl)amino]benzimidazol-l-yl]-2-pyridyl]tria zole-4-carbonitrile (30 mg, 0.070 mmol, 8.68% yield) as white solid, l-[3-acetyl-6-[5-[(6-methylpyridazin-3- yl)amino]benzimidazol-l-yl]-2-pyridyl]triazole-4-carbonitril e (20 mg, 0.050 mmol, 5.8% yield) and 3-[3-acetyl-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol -l-yl]-2-pyridyl]triazole-4- carbonitrile (15 mg, 0.030 mmol, 4.2% yield) as white solids. Regioisomer 1 : LC-MS: m/z = 437.1 [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, DMSO-t/ ₆ ) 8 = 9.93 (s, 1H), 9.28 (s, 1H), 9.19 (s, 1H), 8.63 (d, J= 8.5 Hz, 1H), 8.46 (d, J= 1.9 Hz, 1H), 8.37 (d, J= 8.6 Hz, 1H), 8.28 (d, J= 8.9 Hz, 1H), 7.60 (dd, J= 2.1, 8.9 Hz, 1H), 7.36 (d, J= 9.1 Hz, 1H), 7.11 (d, J= 9.1 Hz, 1H), 2.50 - 2.49 (m, 3H), 2.48 (s, 3H). Regioisomer 2: LC-MS: m/z = 437.1 [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, DMSO-t/e) 6 = 10.20 - 10.08 (m, 1H), 9.15 (s, 1H), 8.51 (d, J= 8.3 Hz, 1H), 8.43 (d, J = 8.9 Hz, 1H), 8.33 (s, 1H), 8.16 (d, J = 8.4 Hz, 1H), 7.86 - 7.77 (m, 1H), 7.60 (br d, J= 8.4 Hz, 1H), 7.55 (dd, J = 2.1, 8.9 Hz, 1H), 7.01 - 6.87 (m, 1H), 2.59 (s, 3H), 1.92 (s, 3H). Regioisomer 3: LC-MS: m/z = 437.1 [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, DMSO-t/ ₆ ) 6 = 10.17 (br s, 1H), 9.25 (s, 1H), 9.02 (s, 1H), 8.61 (d, J= 8.4 Hz, 1H), 8.52 (d, J= 8.9 Hz, 1H), 8.40 (d, J= 8.6 Hz, 1H), 8.25 (d, J= 1.3 Hz, 1H), 7.83 (br d, J= 8.9 Hz, 1H), 7.64 - 7.59 (m, 1H), 7.56 (dd, J= 2.0, 9.0 Hz, 1H), 2.59 (s, 3H), 2.49 - 2.49 (m, 3H).

Step 2: l-[ 3-( 1 -hydroxyethyl)-6-[5-[ ( 6-methylpyridazin-3-yl)amino ]benzimidazol-l-yl ]-2- pyridyl] triazole-4-carbonitrile

Prepared in analogy to example 53, step 4 suing l-[3-acetyl-6-[5-[(6-methylpyridazin-3- yl)amino]benzimidazol-l-yl]-2-pyridyl]triazole-4-carbonitril e (30.0 mg, 0.070 mmol, 1.0 equiv.) and NaBE (8.0 mg, 0.210 mmol, 3.1 equiv.) in DCM/MeOH (1 : 1) to afford l-[3-(l- hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidaz ol-l-yl]-2-pyridyl]triazole-4- carbonitrile (11.3 mg, 0.030 mmol, 37.5% yield) as yellow solid. Purification by HPLC (Waters Xbridge 150 x 25mm x 5um), water (lOmM NH4HCO3)-ACN, 24% - 54%), flow rate 25 mL/min). LCMS:439.1[M+H]+ ESI pos. 'H NMR (400 MHz, DMSO-t/ ₆ ) 8 = 9.84 (s, 1H), 9.23 (s, 1H), 9.07 (s, 1H), 8.53 (d, J= 8.4 Hz, 1H), 8.42 (d, J= 2.0 Hz, 1H), 8.29 (d, J= 8.6 Hz, 1H), 8.15 (d, J= 8.9 Hz, 1H), 7.54 (dd, J= 2.1, 8.9 Hz, 1H), 7.34 (d, J= 9.0 Hz, 1H), 7.09 (d, J= 9.0 Hz, 1H), 5.60 (br s, 1H), 5.00 (q, J= 6.4 Hz, 1H), 2.48 (br s, 3H), 1.40 (d, J= 6.4 Hz, 3H).

Example 254 (3S,5R)-1- [3-(l-hydroxyethyl)-6- [5- [(6-methylpyridazin-3-yl)amino] benzimidazol-l-yl]-2- pyridyl]-5-methyl-pyrrolidine-3-carbonitrile

Step 1: tert-butyl (2R,4R)-2-methyl-4-methylsulfonyloxy-pyrrolidine-l-carboxyla te

Prepared in analogy to example 242, step 1 using tert-butyl (2R,4R)-4-hydroxy-2-methyl- pyrrolidine- 1 -carboxylate (1.0 g, 4.97 mmol, 1.0 equiv.), TEA (2.5 g, 24.9 mmol, 5.0 equiv.) and

MsCl (0.78 mL, 9.95 mmol, 2.0 equiv.) in DCM (10 mL) to give tert-butyl (2R,4R)-2-methyl-4- methylsulfonyloxy-pyrrolidine-l-carboxylate (1.41 g, 5.05 mmol, 96.5% yield) as a yellow oil. 'H NMR (400 MHz, CDC1 ₃ ) 8 = 5.21 - 5.15 (m, 1H), 4.06 - 3.71 (m, 2H), 3.56 (br d, J = 10.4 Hz, 1H), 3.03 (s, 3H), 2.45 (br d, J = 1.6 Hz, 1H), 1.90 - 1.81 (m, 1H), 1.47 (s, 9H), 1.30 - 1.26 (m, 3H).

Step 2: tert-butyl (2R,4S)-4-cyano-2-methyl-pyrrolidine-l-carboxylate

Prepared in analogy to example 242, step 2 using tert-butyl (2R,4R)-2-methyl-4- methylsulfonyloxy-pyrrolidine-l-carboxylate (1.4 g, 5.1 mmol, 1.0 equiv.), sodium cyanide (0.99 g, 20.2 mmol, 4.0 equiv.) and DMSO (15 mL) to yield tert-butyl (2R,4S)-4-cyano-2- methyl-pyrrolidine-1 -carboxylate (660.0 mg, 3.14 mmol, 62.4% yield) as a colorless oil, which was used without purification in the next step. LC-MS: m/z = 155.1 [M-56+H] ⁺ ESI pos. 'H NMR (400 MHz, CDCI3) 6 = 5.21 - 5.15 (m, 1H), 4.06 - 3.71 (m, 2H), 3.56 (br d, J = 10.4 Hz, 1H), 3.03 (s, 3H), 2.45 (br d, J = 1.7 Hz, 1H), 1.90 - 1.81 (m, 1H), 1.47 (s, 9H), 1.30 - 1.26 (m, 3H).

Step 3: (3S,5R)-5-methylpyrrolidine-3-carbonitrile;2,2,2-trifluoroac etic acid

Prepared in analogy to example 242, step 3 using tert-butyl (2R,4S)-4-cyano-2-methyl- pyrrolidine-1 -carboxylate (660.0 mg, 3.14 mmol, 1.0 equiv.) and trifluoroacetic acid (4.1 mL, 53.4 mmol, 17 equiv.) and DCM (5 mL) to yield (3S,5R)-5-methylpyrrolidine-3-carbonitrile (310 mg, 2.81 mmol, 89.5% yield) as a red oil which was used without purification in the next step.

Step 4: (3S, 5R)-l-(3-acetyl-6-methyl-2-pyridyl)-5-methyl-pyrrolidine-3-c arbonitrile

Prepared in analogy to example 105, step 1 using l-(6-chloro-2-fluoro-3-pyridyl)ethanone (CAS# 1260663-13-5, 745.3 mg, 4.3 mmol, 1.1 equiv.) and (3S,5R)-5-methylpyrrolidine-3- carbonitrile (430.0 mg, 3.9 mmol, 1.0 equiv.) to give (3S,5R)-l-(3-acetyl-6-methyl-2-pyridyl)-5- methyl-pyrrolidine-3-carbonitrile (330 mg, 1.36 mmol, 34.75% yield) as a yellow oil. LC-MS: m/z = 264.0 [M+H] ⁺ , ESI pos. 'HNMR (400 MHz, DMSO-t/ ₆ ) 5 = 8.10 (d, J= 8.0 Hz, 1H), 6.84 (d, J = 8.0 Hz, 1H), 4.29 - 4.20 (m, 1H), 3.44 - 3.38 (m, 1H), 3.26 - 3.18 (m, 1H), 3.02 (dd, J = 7.2, 10.0 Hz, 1H), 2.61 - 2.57 (m, 1H), 2.55 (s, 3H), 1.95 - 1.84 (m, 1H), 1.26 (d, J= 6.0 Hz, 3H)

Step 5: (3S, 5R)-l-(3-acetyl-6-chloro-2-pyridyl)-5-methyl-pyrrolidine-3-c arbonitrile Prepared in analogy to example 64, step 2 using (3S,5R)-l-(3-acetyl-6-chloro-2-pyridyl)-5- methyl-pyrrolidine-3-carbonitrile (670.0 mg, 2.54 mmol, 1.0 equiv.) and N-(6-methylpyridazin- 3-yl)-lH-benzimidazol-5-amine (572.26 mg, 2.54 mmol, 1.0 equiv., prepared in example 64, intermediate 1) to yield (3S,5R)-l-(3-acetyl-6-chloro-2-pyridyl)-5-methyl-pyrrolidine -3- carbonitrile (400 mg, 1.52 mmol, 59.6% yield) as a yellow solid after separation of the isomers by preparative HPLC (Phenom enex Luna 75 mm x 30 mm x 3 pm, gradient 22 - 42% CH3CN in H2O (with 0.1% TFA) over 7 min, then 100% CH3CN (2 min), flow rate 25 mL/min). NO LC- MS ‘H NMR (400 MHz, DMSO-t/ ₆ ) 8 = 1.17 (d, J= 5.99 Hz, 3 H) 1.87 - 1.97 (m, 1 H) 2.61 (d, .7= 7.95 Hz, 7 H) 3.31 (br d, = 10.15 Hz, 1 H) 3.36 - 3.41 (m, 1 H) 3.56 (s, 1 H) 4.48 - 4.57 (m, 1 H) 7.28 - 7.37 (m, 2 H) 7.64 (br d, J= 9.29 Hz, 1 H) 7.75 - 7.83 (m, 2 H) 8.35 - 8.38 (m, 1 H) 8.93 - 9.05 (m, 2 H) 10.30 (br s, 1 H).

Step 6: ( 3S, 5R)-l-[ 3-(l -hydroxyethyl)-6-[5-[ ( 6-methylpyridazin-3-yl)amino ]benzimidazol-l-yl ]-

2-pyridyl]-5-methyl-pyrrolidine-3-carbonitrile

Preared in analogy to example 53, step 4 using (3S,5R)-l-[3-acetyl-6-[5-[(6-methylpyridazin-3- yl)amino]benzimidazol-l-yl]-2-pyridyl]-5-methyl-pyrrolidine- 3-carbonitrile (70.0 mg, 0.150 mmol, 1.0 equiv.) and NaBH4 (50.0 mg, 1.32 mmol, 8.5 equiv.) at RT to yield formic acid;(3S,5R)-l-[3-(l-hydroxyethyl)-6-[5-[(6-methylpyridazin- 3-yl)amino]benzimidazol-l-yl]-2- pyridyl]-5-methyl-pyrrolidine-3-carbonitrile (15.3 mg, 0.030 mmol, 20.7% yield) as a yellow solid. LC-MS: m/z = 455.2 [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, CD3OD) 5 = 8.78 (d, J = 2.0 Hz, 1H), 8.35 - 8.26 (m, 1H), 8.21 - 8.05 (m, 3H), 7.68 - 7.60 (m, 1H), 7.47 - 7.35 (m, 2H), 7.16 (d, J= 9.2 Hz, 1H), 5.25 - 5.16 (m, 1H), 4.54 - 4.41 (m, 1H), 4.04 - 3.86 (m, 1H), 3.82 - 3.66 (m, 1H), 3.29 (br s, 1H), 2.71 (dd, J = 6.8, 12.5 Hz, 1H), 2.55 (s, 3H), 2.06 - 1.92 (m, 1H), 1.64 (d, J = 6.4 Hz, 2H), 1.46 (d, J= 6.4 Hz, 2H), 1.30 (t, J= 5.6 Hz, 3H). Example 255

5-[3-(l-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino ]benzimidazol-l-yl]-2-pyridyl]- l-methyl-pyrazole-3-carbonitrile Step 1: 5-[3-acetyl-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol -l-yl]-2-pyridyl]-l- methyl-pyrazole-3-carbonitrile

Prepared in analogy to example 143, step 2 using l-[2-chloro-6-[5-[(6-methylpyridazin-3- yl)amino]benzimidazol-l-yl]-3-pyridyl]ethanone (50.0 mg, 0.130 mmol, 1.0 equiv., prepared in example 76, step 2) and l-methyl-5-(4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2-yl)pyra zole-3- carbonitrile (46.14 mg, 0.200 mmol, 1.5 equiv.) to give 5-[3-acetyl-6-[5-[(6-methylpyridazin-3- yl)amino]benzimidazol-l-yl]-2-pyridyl]-l-methyl-pyrazole-3-c arbonitrile (15 mg, 0.030 mmol, 24.3% yield) as a white solid. LC-MS: m/z = 450.2 [M+H] ⁺ , ESI pos.

Step 2: 5-[ 3-( 1 -hydroxyethyl)-6-[5-[ ( 6-methylpyridazin-3-yl)amino ]benzimidazol-l-yl ]-2- pyridyl ]-l-methyl-pyrazole-3-carbonitrile Prepared in analogy to example 53, step 4 using 5-[3-acetyl-6-[5-[(6-methylpyridazin-3- yl)amino]benzimidazol-l-yl]-2-pyridyl]-l-methyl-pyrazole-3-c arbonitrile (15.0 mg, 0.030 mmol, 1.0 equiv.) at -78 °C to give 5-[3-(l-hydroxyethyl)-6-[5-[(6-methylpyridazin-3- yl)amino]benzimidazol-l-yl]-2-pyridyl]-l-methyl-pyrazole-3-c arbonitrile (11.7 mg, 0.030 mmol, 74.39% yield) as a white solid. LC-MS: m/z = 452.1 [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, CD ₃ OD) 5 ppm 8.95 - 9.08 (m, 1 H) 8.30 - 8.35 (m, 1 H) 8.11 - 8.19 (m, 2 H) 7.97 - 8.02 (m, 1 H) 7.79 - 7.84 (m, 1 H) 7.62 - 7.68 (m, 1 H) 7.40 - 7.46 (m, 1 H) 7.00 - 7.03 (m, 1 H) 4.83 - 4.86 (m, 1 H) 3.83 - 3.87 (m, 3 H) 2.55 - 2.60 (m, 3 H) 1.34 - 1.39 (m, 3 H).

Example 256

2- [3-(l-Hydroxyethyl)-6- [5- [(6-methylpyridazin-3-yl)amino] benzimidazol- 1-yl] -2- pyridyl]triazole-4-carbonitrile

Example 256 was prepared in analogy to example 53, step 4 using 2-[3-acetyl-6-[5-[(6- methylpyridazin-3-yl)amino]benzimidazol-l-yl]-2-pyridyl]tria zole-4-carbonitrile (20.0 mg, 0.050 mmol, 1.0 equiv., prepared in example 253, step 1) and NaBEU (6.0 mg, 0.160 mmol, 3.5 equiv.) in MeOH/DCM to yield 2-[3-(l-hydroxyethyl)-6-[5-[(6-methylpyridazin-3- yl)amino]benzimidazol-l-yl]-2-pyridyl]triazole-4-carbonitril e (13.7 mg, 0.030 mmol, 68.19% yield) as yellow solid. LC-MS: m/z = 439.2[M+H] ⁺ , ESI pos. 'H NMR (400 MHz, DMSO-t/ ₆ ) 8 = 9.23 (s, 1H), 9.03 (d, J= 13.4 Hz, 2H), 8.50 (d, J= 8.6 Hz, 1H), 8.41 (d, J= 1.9 Hz, 1H), 8.34 - 8.25 (m, 2H), 7.52 (dd, J= 2.0, 8.9 Hz, 1H), 7.33 (d, J= 9.1 Hz, 1H), 7.09 (d, J= 9.0 Hz, 1H), 5.59 (br s, 1H), 4.96 (q, J= 6.3 Hz, 1H), 2.48 (s, 3H), 1.36 (d, J= 6.4 Hz, 3H).

Example 263 l-[6-(3-Cyano-5-methyl-pyrazol-l-yl)-5-(l-hydroxyethyl)-2-py ridyl]benzimidazole-5- carbonitrile

Step 1: l-[5-acetyl-6-(3-cyano-5-methyl-pyrazol-l-yl)-2-pyridyl]benz imidazole-5-carbonitrile l-[3-acetyl-6-(5-bromobenzimidazol-l-yl)-2-pyridyl]-5-methyl -pyrazole-3-carbonitrile (30 mg, 0.071 mmol, 1 equiv.) was suspended in 1,4-di oxane (1 mL) and (2S)-pyrrolidine-2- carbonitrile;hydrochloride (10.39 mg, 0.078 mmol, 1.1 equiv.), water (33.49 mg, 33.49 pL, 1.86 mmol, 26 equiv.) and CS2CO3 (69.61 mg, 0.214 mmol, 3.0 equiv.) were added at rt. The reaction mixture was degased with argon before QPhosPd(crotyl)Cl (5.17 mg, 0.006 mmol, 0.08 equiv.) was added. The vial was closed and heated to 80 °C overnight. The reaction mixture was diluted with water and extracted twice with EtOAc. The organic layers were dried over MgSC and concentrated to dryness. The crude material was purified by flash column chromatography (silica gel, 0 - 5% MeOH in DCM) to yield l-[5-acetyl-6-(3-cyano-5-methyl-pyrazol-l-yl)-2- pyridyl]benzimidazole-5-carbonitrile (17.4 mg, 64.5%) as pink solid. LC-MS: m/z = 368.1258 [M+H] ⁺ , ESI pos.

Step 2: l-[6-(3-cyano-5-methyl-pyrazol-l-yl)-5-(l-hydroxyethyl)-2-py ridyl]benzimidazole-5- carbonitrile

Prepared in analogy to example 55, step 3 using l-[5-acetyl-6-(3-cyano-5-methyl-pyrazol-l-yl)- 2-pyridyl]benzimidazole-5-carbonitrile (15 mg, 0.041 mmol, 1.0 equiv.) and NaBEE (3.09 mg, 0.082 mmol, 2.0 equiv.) in THF/'PrOH (1 : 1) at RT to obtain the title compound l-[6-(3-cyano-5- methyl-pyrazol-l-yl)-5-(l-hydroxyethyl)-2-pyridyl]benzimidaz ole-5-carbonitrile (10.2 mg, 67.6%) as white solid. LC-MS: m/z = 370.20 [M+H] ⁺ , ESI pos.

Example 264 l-[2-(l-Ethyl-3-methyl-pyrazol-4-yl)-6-[5-[(6-methylpyridazi n-3-yl)amino]benzimidazol-l- yl]-3-pyridyl] ethanol; formic acid

Step 1: l-ethyl-3-methyl-4-(4, 4, 5, 5-tetramethyl-l, 3, 2-dioxaborolan-2-yl)pyrazole and l-ethyl-5- methyl-4-(4, 4, 5, 5-tetramethyl-l, 3, 2-dioxaborolan-2-yl)pyrazole

A mixture of 3-methyl-4-(4, 4, 5, 5-tetramethyl-l, 3, 2-dioxaborolan-2-yl)-lH-pyrazole (500.0 mg, 2.4 mmol, 1.0 equiv.), iodoethane (0.38 mL, 4.81 mmol, 2.0 equiv.), CS2CO3 (1.57 mg, 4.81 mmol, 2.0 equiv.) and CH3CN (10 mL) was stirred at 75 °C for 12 h. The reaction mixture was filtered and the mother liquor was concentrated under reduced pressure to give a 1 : 1 mixture of l-ethyl-3-methyl-4-(4, 4, 5, 5-tetramethyl-l, 3, 2-dioxaborolan-2-yl)pyrazole and l-ethyl-5-methyl- 4-(4, 4, 5, 5-tetramethyl-l, 3, 2-dioxaborolan-2-yl)pyrazole (560 mg, 2.38 mmol, 98.8% yield) as white gum. LC-MS: m/z = 237.2 [M+H] ⁺ , ESI pos.

Step 2: l-[2-(l-ethyl-3-methyl-pyrazol-4-yl)-6-[5-[(6-methylpyridazi n-3-yl)amino]benzimidazol- 1-yl ]-3-pyridyl ethanone and l-[ 2-( I -ethyl-5-methyl-pyrazol-4-yl)-6-[5-[ ( 6-methylpyridazin-3- yl)amino ]benzimidazol-l-yl ]-3-pyridyl ethanone

Prepared in analogy to example 143, step 2 using l-[2-chloro-6-[5-[(6-methylpyridazin-3- yl)amino]benzimidazol-l-yl]-3-pyridyl]ethanone (120.0 mg, 0.320 mmol, 1.0 equiv., prepared in example 76, step 2) and l-ethyl-3-methyl-4-(4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2 - yl)pyrazole to give a mixture of l-[2-(l-ethyl-5-methyl-pyrazol-4-yl)-6-[5-[(6-methylpyridazi n- 3-yl)amino]benzimidazol-l-yl]-3-pyridyl]ethanone and l-[2-(l-ethyl-3-methyl-pyrazol-4-yl)-6- [5-[(6-methylpyridazin-3-yl)amino]benzimidazol-l-yl]-3-pyrid yl]ethanone (60 mg, 0.14 mmol, 41.8% yield) as yellow solid. LC-MS: m/z = 453.0 [M+H] ⁺ , ESI pos.

Step 3: l-[2-(l-ethyl-3-methyl-pyrazol-4-yl)-6-[5-[(6-methylpyridazi n-3-yl)amino]benzimidazol- 1-yl ]-3-pyridyl ethanol; formic acid

Prepared in analogy to example 53, step 4 using l-[2-(l-ethyl-3-methyl-pyrazol-4-yl)-6-[5-[(6- methylpyridazin-3-yl)amino]benzimidazol-l-yl]-3-pyridyl]etha none (30.0 mg, 0.070 mmol, 1.0 equiv.) and NaBH4 (12.61 mg, 0.330 mmol, 5.0 equiv.) to yield l-[2-(l-ethyl-3-methyl-pyrazol- 4-yl)-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-l-yl] -3-pyridyl]ethanol; formic acid (18.2 mg, 0.040 mmol, 54.2% yield) after purification by preparative HPLC (Phenomenex Luna C18 150 mm x 25mm x 10 pm, gradient 10 - 30% CH3CN in H2O (with 0.225% formic acid) over 10 min, then 100% CH3CN (2 min), flow rate 25 mL/min, 1 injection). LC-MS: m/z = 455.1 [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, CD3OD) 5 = 8.82 (s, 1H), 8.27 (d, J= 8.4 Hz, 1H), 8.23 (br s, 1H), 8.18 (d, J= 2.0 Hz, 1H), 8.16 (d, J = 92 Hz, 1H), 7.87 (s, 1H), 7.80 (d, J = 8.4 Hz, 1H), 7.60 - 7.52 (m, 1H), 7.37 (d, J= 9.2 Hz, 1H), 7.15 (d, J= 9.2 Hz, 1H), 5.08 - 5.02 (m, 1H), 4.30 - 4.15 (m, 2H), 2.53 (s, 3H), 2.34 (s, 3H), 1.52 (t, J= 7.2 Hz, 3H), 1.47 (d, J= 6.4 Hz, 3H). Example 265

1 - 12- [l-(2-Methoxyethyl)-3-methyl-pyrazol-4-yl]-6- [5- [(6-methylpyridazin-3- yl)amino]benzimidazol-l-yl]-3-pyridyl]ethanol; formic acid

Step 1 : l-(2-methoxyethyl)-5-methyl-4-( 4, 4, 5, 5 -tetr ame thy l-l , 3, 2-dioxaborolan-2-yl)pyrazole and l-(2-methoxyethyl)-3-methyl-4-(4,4,5,5-tetramethyl-l, 3,2-dioxaborolan-2-yl)pyrazole

A mixture of CS2CO3 (1.57 g, 4.81 mmol, 2.0 equiv.), 3-methyl-4-(4,4,5,5-tetramethyl-l,3,2- dioxaborolan-2-yl)-lH-pyrazole (500.0 mg, 2.4 mmol, 1.0 equiv.), 2-bromoethyl methyl ether (0.25 mL, 2.64 mmol, 1.1 equiv.) and CH3CN (10 mL) was stirred at 80 °C for 12 h. The reaction mixture was filtered and the filter liquor was concentrated under reduced pressure to give a 1 : 1 mixture of l-(2-methoxyethyl)-5-methyl-4-(4,4,5,5-tetramethyl-l,3,2-dio xaborolan-2- yl)pyrazole and l-(2-methoxyethyl)-3-methyl-4-(4,4,5,5-tetramethyl-l,3,2-dio xaborolan-2- yl)pyrazole (600 mg, 2.26 mmol, 93.8% yield) as brown oil. LC-MS: m/z = 267.2 [M+H] ⁺ , ESI pos.

Step 2: l-[ 2-[ l-(2-methoxyethyl)-3-methyl-pyrazol-4-yl ]-6-[5-[ ( 6-methylpyridazin-3- yl)amino]benzimidazol-l-yl] -3-pyridyl] ethanone and l-[2-[ l-(2-methoxyethyl)-5-methyl- pyrazol-4-yl] -6-[5-[ ( 6-methylpyridazin-3-yl)amino ]benzimidazol-l-yl / -3-pyridyl ethanone

Prepared in analogy to example 143, step 2 using l-[2-chloro-6-[5-[(6-methylpyridazin-3- yl)amino]benzimidazol-l-yl]-3-pyridyl]ethanone (150.0 mg, 0.400 mmol, 1.0 equiv., prepared in example 76, step 2) and l-(2-methoxyethyl)-5-methyl-4-(4,4,5,5-tetramethyl-l,3,2-dio xaborolan-

2-yl)pyrazole (158.07 mg, 0.590 mmol, 1.5 equiv.) to yield a 1:1 mixture of l-[2-[l-(2- methoxyethyl)-5-methyl-pyrazol-4-yl]-6-[5-[(6-methylpyridazi n-3-yl)amino]benzimidazol-l-yl]-

3 -pyridyl] ethanone and l-[2-[l-(2-methoxyethyl)-3-methyl-pyrazol-4-yl]-6-[5-[(6- methylpyridazin-3-yl)amino]benzimidazol-l-yl]-3-pyridyl]etha none (80 mg, 0.16 mmol, 41.8% yield) as yellow solid. LC-MS: m/z = 483.3 [M+H] ⁺ , ESI pos.

Step 3: l-[ 2-[ l-(2-methoxyethyl)-3-methyl-pyrazol-4-yl ]-6-[5-[ ( 6-methylpyridazin-3- yl)amino ]benzimidazol-l-yl ]-3-pyridyl ethanol; formic acid

Prepared in analogy to example 53, step 4 using l-[2-[l-(2-methoxyethyl)-3-methyl-pyrazol-4- yl]-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-l-yl]-3 -pyridyl]ethanone (30.0 mg, 0.060 mmol, 1.0 equiv.) and NaBH4 (11.82 mg, 0.310 mmol, 5.0 equiv.) to yield l-[2-[l-(2- methoxyethyl)-3-methyl-pyrazol-4-yl]-6-[5-[(6-methylpyridazi n-3-yl)amino]benzimidazol-l-yl]- 3-pyridyl]ethanol; formic acid (20.6 mg, 0.040 mmol, 68.4% yield) as yellow solid after purification by preparative HPLC (Phenomenex Luna C18 150 mm x 25 mm, 10 pm, gradient 20 - 40% CH3CN in H2O (with 0.225% formic acid), flow rate 25 mL/min). LC-MS: m/z = 485.1 [M+H] ⁺ , ESI pos. ^J H NMR (400 MHz, CD ₃ OD) 5 = 8.81 (s, 1H), 8.27 (d, = 8.4 Hz, 1H), 8.21 - 8.09 (m, 2H), 7.87 (s, 1H), 7.79 (d, J= 8.4 Hz, 1H), 7.60 - 7.52 (m, 1H), 7.36 (d, J= 9.2 Hz, 1H), 7.14 (d, J = 9.2 Hz, 1H), 5.14 - 5.03 (m, 1H), 4.33 (t, J = 5.2 Hz, 2H), 3.78 (t, J = 5.2 Hz, 2H), 3.37 (s, 3H), 2.53 (s, 3H), 2.34 (s, 3H), 1.47 (d, J= 6.4 Hz, 3H).

Example 266 l-[2-[l-(Cyclopropylmethyl)-3-methyl-pyrazol-4-yl]-6-[5-[(6- methylpyridazin-3- yl)amino]benzimidazol-l-yl]-3-pyridyl]ethanol;formic acid

Step 1 : l-(cyclopropylmethyl)-5-methyl-4-( 4, 4, 5, 5 -tetr ame thy l-l , 3, 2-dioxaborolan-2-yl)pyrazole and l-(cyclopropylmethyl)-3-methyl-4-(4,4,5,5-tetramethyl-l, 3,2-dioxaborolan-2-yl)pyrazole

A mixture of 3-methyl-4-(4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2-yl)-lH- pyrazole (500.0 mg, 2.4 mmol, 1.0 equiv.), (bromomethyl)cyclopropane (0.26 mL, 2.64 mmol, 1.1 equiv.) and CS2CO3 (1.57 mg, 4.81 mmol, 2 equiv.) in CH3CN (10 mL) was stirred at 80 °C for 12 h. The reaction mixture was filtered and the mother liquor was concentrated under reduced pressure to give a 2: 1 mixture of l-(cyclopropylmethyl)-5-methyl-4-(4,4,5,5-tetramethyl-l,3,2- dioxaborolan- 2-yl)py ^razo le and l-(cyclopropylmethyl)-3-methyl-4-(4,4,5,5-tetramethyl-l,3,2- dioxaborolan-2- yl)pyrazole (600 mg, 2.28 mmol, 95.4% yield) as yellow gum. LC-MS: m/z = 263.1 [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, CDCI3) 8 = 7.76 (s, 1H), 7.73 (s, 1H), 3.99 (t, J = 6.9 Hz, 4H), 2.50 - 2.43 (m, 7H), 1.33 - 1.30 (m, 25H), 0.70 - 0.62 (m, 3H), 0.61 - 0.51 (m, 2H), 0.45 - 0.34 (m, 4H).

Step 2: l-[ 2-[ l-(cyclopropylmethyl)-3-methyl-pyrazol-4-yl ]-6-[5-[ ( 6-methylpyridazin-3- yl)amino]benzimidazol-l-yl] -3-pyridyl] ethanone and l-[2-[ l-(cyclopropylmethyl)-5-methyl- pyrazol-4-yl] -6-[5-[ ( 6-methylpyridazin-3-yl)amino ]benzimidazol-l-yl / -3-pyridyl ethanone

Prepared in analogy to example 143, step 2 using l-(cyclopropylmethyl)-5-methyl-4-(4, 4,5,5- tetramethyl-l,3,2-dioxaborolan-2-yl)pyrazole (249.1 mg, 0.950 mmol, 3.0 equiv.) and l-[2- chloro-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-l-yl ]-3-pyridyl]ethanone (120.0 mg, 0.32 mmol, 1.0 equivto yield a 2:1 mixture of l-[2-[l-(cyclopropylmethyl)-3-methyl-pyrazol-4- yl]-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-l-yl]-3 -pyridyl]ethanone and l-[2-[l- (cyclopropylmethyl)-5-methyl-pyrazol-4-yl]-6-[5-[(6-methylpy ridazin-3-yl)amino]benzimidazol- 1-yl] -3 -pyridyl] ethanone (69 mg, 0.15 mmol, 45.6% yield) as yellow solid. LC-MS: m/z = 479.2 [M+H] ⁺ , ESI pos.

Step 3: l-[2-[l-(cyclopropylmethyl)-3-methyl-pyrazol-4-yl]-6-[5-[(6- methylpyridazin-3- yl)amino ]benzimidazol-l-yl ]-3-pyridyl ethanol; formic acid

Prepared in analogy to example 53, step 4 using l-[2-[l-(cyclopropylmethyl)-3-methyl-pyrazol- 4-yl]-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-l-yl] -3-pyridyl]ethanone (30.0 mg, 0.060 mmol, 1.0 equiv.) in methanol (2 mL) and NaBH4 (11.92 mg, 0.310 mmol, 5 equiv.) to yield l-[2-[l-(cyclopropylmethyl)-3-methyl-pyrazol-4-yl]-6-[5-[(6- methylpyridazin-3- yl)amino]benzimidazol-l-yl]-3-pyridyl]ethanol; formic acid (20.6 mg, 0.040 mmol, 68.4% yield) as yellow solid after purification by preparative HPLC (Phenomenex Luna C18 150 mm x 25mm x 10 pm, gradient 20 - 40% CH3CN in H2O (with 0.225% formic acid) over 10 min, then 100% CH3CN (2 min), flow rate 25 mL/min). LC-MS: m/z = 481.2 [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, CD3OD) 5 = 8.82 (s, 1H), 8.27 (d, J= 8.4 Hz, 1H), 8.21 (s, 1H), 8.20 - 8.14 (m, 2H), 7.92 (s, 1H), 7.80 (d, J = 8.4 Hz, 1H), 7.60 - 7.53 (m, 1H), 7.37 (d, J= 9.2 Hz, 1H), 7.16 (d, J = 92 Hz, 1H), 5.09 - 5.03 (m, 1H), 4.03 (d, J= 7.2 Hz, 2H), 2.53 (s, 3H), 2.35 (s, 3H), 1.48 (d, J= 6.4 Hz, 3H), 1.42 - 1.30 (m, 1H), 0.70 - 0.62 (m, 2H), 0.49 - 0.39 (m, 2H).

Example 269

5-Methyl-l-[3-methylol-6-[6-[(6-methylpyridazin-3-yl)amin o]benzimidazol-l-yl]-2- pyridyl]pyrazole-3-carbonitrile; formic acid

Step 1 : l-( 6-chloro-3-methylol-2-pyridyl)-5-methyl-pyrazole-3-carbonitr ile l-(6-chloro-3-formyl-2-pyridyl)-5-methyl-pyrazole-3-carbonit rile (100 mg, 0.405 mmol, 1.0 equiv., prepared in example 243, step 2) was dissolved in MeOH (1 mL). NaBH4 (757.49 ug, 0.020 mmol, 3.0 equiv.) was added and the reaction nmixture was stirred at RT over 30 minutes. Water was added and the product was purified by reverse phase chromatography to yield the title compound (75 mg, 70.7% yield) as white lyophilized powder. LC-MS: m/z = 249.1 [M+H] ⁺ , ESI pos. Step 2: 5-methyl-l-[ 3-methylol-6-[ 6-[ ( 6-methylpyridazin-3-yl)amino ]benzimidazol-l-yl ]-2- pyridyl]pyrazole-3-carbonitrile; formic acid and 5-methyl-l-[3-methylol-6-[5-[(6- methylpyridazin-3-yl)amino ]benzimidazol-l-yl / -2 -pyridyl ]pyrazole-3-carbonitrile; formic acid Prepared in analogy to example 65, step 2 using l-(6-chloro-3-methylol-2-pyridyl)-5-methyl- pyrazole-3 -carbonitrile (75 mg, 0.302 mmol, 1.0 equiv.) and lH-benzimidazol-5-yl-(6- m ethyl pyridazin-3-yl)amine (81.52 mg, 0.362 mmol, 1.2 equiv., prepared in example 64, intermediate 1) to yield the title compounds : 5-methyl-l-[3-methylol-6-[6-[(6-methylpyridazin- 3-yl)amino]benzimidazol-l-yl]-2-pyridyl]pyrazole-3-carbonitr ile; formic acid (3.0 mg, 2.0% yield) and 5-methyl-l-[3-methylol-6-[5-[(6-methylpyridazin-3-yl)amino]b enzimidazol-l-yl]-2- pyridyl]pyrazole-3-carbonitrile; formic acid (2.0 mg, 1.4% yield) as light yellow lyophilized powders. Regioisomer 1 : LC-MS: m/z = 438.3 [M+H] ⁺ , ESI pos. 'H NMR (600 MHz, DMSO- tZ ₆ ) 8 = 9.26 (s, 1 H), 8.88 (s, 1 H), 8.83 (d, J= 1.8 Hz, 1 H), 8.41 (d, J= 8.4 Hz, 1 H), 8.19 (d, J = 8.5 Hz, 1 H), 7.68 (d, J = 9.1 Hz, 1 H), 7.42 (dd, J= 8.8, 2.1 Hz, 1 H), 7.29 (d, J = 92 Hz, 1 H), 7.06 (d, J= 9.0 Hz, 1 H), 7.01 (d, J= 0.9 Hz, 1 H), 5.50 (t, J= 5.5 Hz, 1 H), 4.42 (d, J= 4.9 Hz, 2 H), 2.39 (d, J = 0.8 Hz, 3 H). Regioisomer 2: LC-MS: m/z = 438.3 [M+H] ⁺ , ESI pos. 'H NMR (600 MHz, DMSO-t/ ₆ ) 6 = 9.21 (s, 1 H), 9.00 (s, 1 H), 8.35 - 8.46 (m, 1 H), 8.31 - 8.41 (m, 2 H), 8.21 - 8.23 (m, 1 H), 8.24 (d, J= 8.5 Hz, 1 H), 8.05 (d, J= 8.8 Hz, 1 H), 7.49 (dd, J= 8.9, 2.1 Hz, 1 H), 7.39 - 7.53 (m, 1 H), 7.33 (d, J = 9.1 Hz, 1 H), 7.06 - 7.20 (m, 2 H), 5.60 (s, 1 H), 4.42 (s, 2 H), 2.38 (d, J = 0.8 Hz, 3 H).

Example 270

5-Methyl-l-[3-methylol-6-[5-[(6-methylpyridazin-3-yl)amin o]benzimidazol-l-yl]-2- pyridyl]pyrazole-3-carbonitrile; formic acid

Prepared in analogy to example 65, step 2 using l-(6-chloro-3-methylol-2-pyridyl)-5-methyl- pyrazole-3 -carbonitrile (75 mg, 0.302 mmol, 1.0 equiv., prepared in example 269, step 1) and lH-benzimidazol-5-yl-(6-methylpyridazin-3-yl)amine (81.52 mg, 0.362 mmol, 1.2 equiv., prepared in example 64, intermediate 1) to yield the title compound (3.0 mg, 2.0% yield) (2.0 mg, 1.4% yield) as light yellow lyophilized powders. LC-MS: m/z = 438.3 [M+H] ⁺ , ESI pos. Example 271 l-[2-(l-Ethyl-5-methyl-pyrazol-4-yl)-6-[5-[(6-methylpyridazi n-3-yl)amino]benzimidazol-l- yl]-3-pyridyl]ethanol;formic acid

Prepared in analogy to example 53, step 4 using l-[2-(l-ethyl-5-methyl-pyrazol-4-yl)-6-[5-[(6- methylpyridazin-3-yl)amino]benzimidazol-l-yl]-3-pyridyl]etha none (15.0 mg, 0.030 mmol, 1.0 equiv., prepared in example 264, step 2) and NaBELj (6.3 mg, 0.170 mmol, 5.0 equiv.) to yield the title compound (6.9 mg, 45.2% yield) as yellow solid. LC-MS: m/z =455.1 [M+H] ⁺ , ESI pos. ^J H NMR (400 MHz, CD ₃ OD) 5 = 8.82 (s, 1H), 8.28 (d, J = 8.4 Hz, 2H), 8.20 - 8.11 (m, 2H), 7.81 (d, J= 8.4 Hz, 1H), 7.69 (s, 1H), 7.62 - 7.55 (m, 1H), 7.36 (d, J = 9.2 Hz, 1H), 7.14 (d, J= 9.2 Hz, 1H), 5.15 - 5.06 (m, 1H), 4.30 - 4.19 (m, 2H), 2.53 (s, 3H), 2.43 (s, 3H), 1.50 - 1.44 (m, 6H).

Example 272 l-[2-[l-(Cyclopropylmethyl)-5-methyl-pyrazol-4-yl]-6-[5-[(6- methylpyridazin-3- yl)amino]benzimidazol-l-yl]-3-pyridyl]ethanol; formic acid

Prepared in analogy to example 53, step 4 using l-[2-[l-(cyclopropylmethyl)-5-methyl-pyrazol- 4-yl]-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-l-yl] -3-pyridyl]ethanone (15.0 mg, 0.030 mmol, 1.0 equiv., prepared in example 266, step 2) and NaBELj (5.96 mg, 0.160 mmol, 5.0 equiv.) to yield l-[2-[l-(cyclopropylmethyl)-5-methyl-pyrazol-4-yl]-6-[5-[(6- methylpyridazin-3- yl)amino]benzimidazol-l-yl]-3-pyridyl]ethanol; formic acid (9.2 mg, 0.020 mmol, 61.1% yield) as yellow solid. LC-MS: m/z = 481.0 [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, CD ₃ OD) 5 = 8.83 (s, 1H), 8.29 (d, J = 8.4 Hz, 1H), 8.27 - 8.23 (m, 1H), 8.17 (d, J= 2.0 Hz, 1H), 8.15 (d, J = 8.8 Hz, 1H), 7.82 (d, J = 8.4 Hz, 1H), 7.69 (s, 1H), 7.61 - 7.55 (m, 1H), 7.37 (d, J= 92 Hz, 1H), 7.14 (d, J= 9.2 Hz, 1H), 5.14 - 5.08 (m, 1H), 4.10 (d, J= 6.8 Hz, 2H), 2.53 (s, 3H), 2.44 (s, 3H), 1.47 (d, J= 6.4 Hz, 3H), 1.40 - 1.26 (m, 1H), 0.68 - 0.57 (m, 2H), 0.50 - 0.42 (m, 2H).

Example 273 l-[2-[l-(Cyclobutylmethyl)-5-methyl-pyrazol-4-yl]-6-[5-[(6-m ethylpyridazin-3- yl)amino]benzimidazol-l-yl]-3-pyridyl]ethanol; formic acid

Step 1: l-(cyclobutylmethyl)-3-methyl-4-(4, 4, 5,5-tetramethyl-l, 3, 2-dioxaborolan-2-yl)pyrazole and l-(cyclobutylmethyl)-5-methyl-4-(4, 4, 5,5-tetramethyl-l, 3, 2-dioxaborolan-2-yl)pyrazole

Prepared in analogy to example 264, step 1 using 3-methyl-4-(4, 4, 5,5-tetramethyl-l, 3,2- dioxaborolan-2-yl)-lH-pyrazole (500.0 mg, 2.4 mmol, 1.0 equiv.) and (bromomethyl)cyclobutane (393.94 mg, 2.64 mmol, 1.1 equiv.) to yield a 1 : 1 mixture of 1- (cyclobutylmethyl)-3-methyl-4-(4, 4, 5,5-tetramethyl-l, 3, 2-dioxaborolan-2-yl)pyrazole and 1- (cyclobutylmethyl)-5-methyl-4-(4, 4, 5,5-tetramethyl-l, 3, 2-dioxaborolan-2-yl)pyrazole (590 mg, 1.07 mmol, 88.9% yield) as a yellow oil. LC-MS: m/z = 277.2 [M+H] ⁺ , ESI pos.

Step 2: l-[2-[ I -(cyclobutylmethyl)-3-methyl-pyrazol-4-yl ]-6-[5-[ ( 6-methylpyridazin-3- yl)amino ]benzimidazol-l-yl ]-3-pyridyl ethanone and l-[ 2-[ 1 -(cyclobutylmethyl) -5 -me thy l- pyrazol-4-yl] -6-[5-[ ( 6-methylpyridazin-3-yl)amino ]benzimidazol-l-yl ]-3-pyridyl ethanone

Prepared in analogy to example 143, step 2 using l-[2-chloro-6-[5-[(6-methylpyridazin-3- yl)amino]benzimidazol-l-yl]-3-pyridyl]ethanone (150.0 mg, 0.400 mmol, 1.0 equiv., prepared in example 76, step 2) and l-(cyclobutylmethyl)-3-methyl-4-(4,4,5,5-tetramethyl-l,3,2- dioxaborolan-2-yl)pyrazole (328.07 mg, 1.19 mmol, 3.0 equiv.), to yield l-[2-[l- (cyclobutylmethyl)-3-methyl-pyrazol-4-yl]-6-[5-[(6-methylpyr idazin-3-yl)amino]benzimidazol- 1-yl] -3 -pyridyl] ethanone (35 mg, 17.9% yield) as a yellow solid and l-[2-[l-(cyclobutylmethyl)- 5-methyl-pyrazol-4-yl]-6-[5-[(6-methylpyridazin-3-yl)amino]b enzimidazol-l-yl]-3- pyridyl] ethanone (25 mg, 12.8% yield) as an orange solid after separation by SFC (Chiralpak AS-3 250 mm x 30 mm, 10 pm, MeOH (with 0.1% ammonium hydroxide)). Regioisomer 1 : LC- MS: m/z = 493.1 [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, DMSO-t/ ₆ ) 8 = 9.23 (s, 1H), 9.02 (s, 1H), 8.44 (d, J= 2.0 Hz, 1H), 8.25 (d, J= 8.8 Hz, 1H), 8.19 (d, J= 8.6 Hz, 1H), 7.93 (s, 1H), 7.91 (s, 1H), 7.50 (dd, J= 2.0, 8.9 Hz, 1H), 7.33 (d, J= 9.2 Hz, 1H), 7.08 (d, J = 9.0 Hz, 1H), 4.14 (d, J= 7.3 Hz, 2H), 2.83 - 2.74 (m, 1H), 2.48 (s, 3H), 2.32 (s, 3H), 2.27 (s, 3H), 2.04 - 1.95 (m, 2H), 1.90 - 1.76 (m, 4H). Regioisomer 2: LC-MS: m/z = 493.1 [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, DMSO-t/e) 6 = 9.23 (s, 1H), 9.04 (s, 1H), 8.43 (d, J = 1.8 Hz, 1H), 8.26 (d, J = 8.8 Hz, 1H), 8.21 (d, J = 8.4 Hz, 1H), 7.93 (d, J= 8.4 Hz, 1H), 7.56 (s, 1H), 7.51 (dd, J= 2.0, 8.9 Hz, 1H), 7.33 (d, J= 9.0 Hz, 1H), 7.08 (d, J= 9.2 Hz, 1H), 4.17 (d, J= 7.1 Hz, 2H), 2.86 - 2.77 (m, 1H), 2.48 (s, 3H), 2.39 (s, 3H), 2.33 (s, 3H), 2.02 - 1.94 (m, 2H), 1.89 - 1.79 (m, 4H).

Step 3: l-[2-[ 1 -(cyclobutylmethyl)-5-methyl-pyrazol-4-yl ]-6-[5-[ ( 6-methylpyridazin-3- yl)amino ]benzimidazol-l-yl ]-3-pyridyl ethanol; formic acid Prepared in analogy to example 55, step 5 using l-[2-[l-(cyclobutylmethyl)-5-methyl-pyrazol-4- yl]-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-l-yl]-3 -pyridyl]ethanone (25.0 mg, 0.050 mmol, 1.0 equiv.) and NaBH4 (9.6 mg, 0.250 mmol, 5.0 equiv.) to yield l-[2-[l- (cyclobutylmethyl)-5-methyl-pyrazol-4-yl]-6-[5-[(6-methylpyr idazin-3-yl)amino]benzimidazol-

1-yl] -3 -pyridyl] ethanol; formic acid (23.3 mg, 0.040 mmol, 84.92% yield) as a yellow solid LC- MS: m/z = 495.0 [M+H] ⁺ , ESI pos. 'H NMR (400 MHz, CD ₃ OD) 5 = 8.83 (s, 1H), 8.28 (d, J = 8.6 Hz, 1H), 8.21 (s, 1H), 8.18 (d, J= 2.0 Hz, 1H), 8.15 (d, J= 8.8 Hz, 1H), 7.81 (d, J= 8.4 Hz, 1H), 7.68 (s, 1H), 7.57 (dd, J = 2.0, 8.8 Hz, 1H), 7.38 (d, J = 92 Hz, 1H), 7.15 (d, J= 9.2 Hz, 1H), 5.09 (q, J= 6.4 Hz, 1H), 4.22 (d, J= 7.2 Hz, 2H), 2.90 (td, J= 7.6, 14.8 Hz, 1H), 2.53 (s, 3H), 2.42 (s, 3H), 2.13 - 2.05 (m, 2H), 1.98 - 1.86 (m, 4H), 1.45 (d, J= 6.4 Hz, 3H).

Example 274 l-[2-[l-(Cyclobutylmethyl)-3-methyl-pyrazol-4-yl]-6-[5-[(6-m ethylpyridazin-3- yl)amino]benzimidazol-l-yl]-3-pyridyl]ethanol

Prepared in analogy to example 55, step 5 using l-[2-[l-(cyclobutylmethyl)-3-methyl-pyrazol-4- yl]-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-l-yl]-3 -pyridyl]ethanone (33.0 mg, 0.070 mmol, 1.0 equiv., prepared in example 273, step 2) to yield l-[2-[l-(cyclobutylmethyl)-3- methyl-pyrazol-4-yl]-6-[5-[(6-methylpyridazin-3-yl)amino]ben zimidazol-l-yl]-3-pyridyl]ethanol (20.8 mg, 0.040 mmol, 61.5% yield) as a yellow solid. LC-MS: m/z = 495.0 [M+H] ⁺ , ESI pos. ^J H NMR (400 MHz, CD3OD) 5 = 8.82 (s, 1H), 8.27 (d, J = 8.4 Hz, 1H), 8.19 (d, J = 2.0 Hz, 1H), 8.16 (d, J= 8.9 Hz, 1H), 7.85 (s, 1H), 7.80 (d, J= 8.4 Hz, 1H), 7.57 (dd, J = 2.0, 8.9 Hz, 1H), 7.37 (d, J= 9.2 Hz, 1H), 7.14 (d, J= 9.0 Hz, 1H), 5.04 (q, J= 6.4 Hz, 1H), 4.18 (d, J= 7.3 Hz, 2H), 2.89 (td, J = 7.5, 15.2 Hz, 1H), 2.53 (s, 3H), 2.33 (s, 3H), 2.15 - 2.07 (m, 2H), 1.99 - 1.84 (m, 4H), 1.46 (d, J= 6.5 Hz, 3H). Example 276

1- [3- [(1 S)- 1-hydroxy ethyl] -6- [5- [(6-methylpyridazin-3-yl)amino] benzimidazol- 1-yl] -2- pyridyl]-5-methyl-pyrazole-3-carboximidic acid methyl ester

Example 276 was isolated as a by-product during the purification of Example 109 and Example 110 (22 mg, 6% yield) as a white powder. LC-MS: m/z = 484.2 [M+H] ⁺ , ESI pos. ^J H NMR (600 MHz, CDC1 ₃ ) 8 ppm 8.59 (s, 1 H), 8.34 (d, J= 8.4 Hz, 1 H), 8.02 - 8.24 (m, 1 H), 8.01 (d, J = 8.8 Hz, 1 H), 7.77 (d, J= 1.9 Hz, 1 H), 7.72 (d, J= 8.4 Hz, 1 H), 7.37 (dd, J= 8.7, 2.2 Hz, 1 H), 7.12 - 7.15 (m, 1 H), 7.06 - 7.09 (m, 1 H), 6.96 (br d, J= 1.1 Hz, 1 H), 6.60 (s, 1 H), 4.90 (q, J = 6.5 Hz, 1 H), 3.98 - 4.21 (m, 1 H), 3.97 (s, 3 H), 2.61 (s, 3 H), 2.49 (d, J= 0.7 Hz, 3 H), 1.51 - 1.53 (m, 3 H).

Example 280

1- [3- [(1 S)- 1-hydroxy ethyl] -6- [6- [(6-methylpyridazin-3-yl)amino] benzimidazol- 1-yl] -2- pyridyl]-5-methyl-pyrazole-3-carbonitrile

Example 280 was isolated as a regioisomer during the preparation of Example 109 and Example 110 (28 mg, 7% yield) as a white powder. LC-MS: m/z = 452.3 [M+H] ⁺ , ESI pos. 'H NMR (600 MHz, CDCI3) 6 ppm 8.50 (s, 1 H), 8.38 (d, J= 8.4 Hz, 1 H), 8.35 (d, J= 1.7 Hz, 1 H), 7.78 (dd, J= 8.3, 7.2 Hz, 2 H), 7.19 (dd, J= 8.7, 2.1 Hz, 1 H), 7.12 (d, J= 92 Hz, 2 H), 6.99 (d, J= 92 Hz, 1 H), 6.65 (s, 1 H), 5.30 (s, 1 H), 4.84 (d, J= 6.5 Hz, 1 H), 2.61 (s, 3 H), 2.44 (d, J= 0.8 Hz, 3 H), 1.47 - 1.53 (m, 4 H), 1.23 - 1.26 (m, 1 H). Example 304 l-[3-(l-hydroxyethyl)-6-[5-[[6-[l-(oxetan-3-yl)pyrrolidin-2- yl]pyridazin-3- yl]amino]benzimidazol-l-yl]-2-pyridyl]-5-methyl-pyrazole-3-c arbonitrile

Step 1: tert-butyl 2-(6-aminopyridazin-3-yl)pyrrolidine-l-carboxylate

An oven-dried 15 mL vial equipped with magnetic stir bar was charged with 6-iodopyridazin-3- amine (1.00 g, 4.52 mmol, 1.0 eq), l-(tert-butoxycarbonyl)pyrrolidine-2-carboxylic acid (1.27 g, 5.88 mmol, 1.3 eq), Ir[dF(CF3)ppy]2(dtbpy)(PFe) (51 mg, 0.05 mmol, 0.01 eq), NiCh.dtbbpy (90 mg, 0.23 mmol, 0.05 eq) , CS2CO3 (2.21 g, 6.79 mmol, 1.5 eq) in DMA (40 mL). The reaction mixture was bubbled with N2 for 10 minutes then irradiated with two 34 W blue LED lamps (approximately 7 cm away from the light source to keep the reaction temperature at 25 °C) for 12 hours. The reaction mixture was poured into H2O (150 mL) and extracted with EtOAc (3 x 40 mL). The combined organic layers were dried over Na2SO4, filtered and concentracted. The residue was purified by preparative HPLC (Waters Xbridge 150 mm x 25 mm x 5 pm, water (lOmM NH4HCO3)-ACN) to give tert-butyl 2-(6-aminopyridazin-3-yl)pyrrolidine-l -carboxylate (120 mg, 0.45 mmol, 10% yield) as white solid. LC-MS: m/z = 265.1 [M+H]+, ESI pos.

Step 2: tert-butyl 2-[6-[[l-[5-acetyl-6-(3-cyano-5-methyl-pyrazol-l-yl)-2-pyrid yl]benzimidazol- 5-yl amino ]pyridazin-3-yl pyrrolidine- 1 -carboxylate

To a solution of tert-butyl 2-(6-aminopyridazin-3-yl)pyrrolidine-l -carboxylate (69 mg, 0.26 mmol, 1.1 eq) and l-[3-acetyl-6-(5-bromobenzimidazol-l-yl)-2-pyridyl]-5-methyl -pyrazole-3- carbonitrile (100 mg, 0.24 mmol, 1.0 eq, prepared in example 65, step 1) in 1,4-dioxane (8 mL) was added CS2CO3 (232 mg, 0.71 mmol, 3.0 eq). The mixture was bubbled with N2 for 10 minutes and [tBuBrettPhos Pd(allyl)]OTf (19 mg, 0.02 mmol, 0.1 eq) was added. The reaction mixture was stirred at 80 °C for 2 hours. The mixture was cooled to RT, poured into H2O (20 mL) and extracted with EtOAc (3 x 20ml). The combined organic layers were washed with brine (20mL), dried over Na2SO4, filtered and concentrated. The residue was purified by preparative TLC (DCM: MeOH 10: 1) to give tert-butyl 2-[6-[[l-[5-acetyl-6-(3-cyano-5-methyl-pyrazol-l- yl)-2-pyridyl]benzimidazol-5-yl]amino]pyridazin-3-yl]pyrroli dine-l-carboxylate (110 mg, 0.18 mmol, 77% yield) as light brown solid. LC-MS: m/z = 605.2 [M+H]+, ESI pos.

Step 3: l-[ 3-acetyl-6-[5-[ ( 6-pyrrolidin-2-ylpyridazin-3-yl)amino ]benzimidazol-l-yl ]-2-pyridyl ]- 5-methyl-pyrazole-3-carbonitrile

To a solution of tert-butyl 2-[6-[[l-[5-acetyl-6-(3-cyano-5-methyl-pyrazol-l-yl)-2- pyridyl]benzimidazol-5-yl]amino]pyridazin-3-yl]pyrrolidine-l -carboxylate (30 mg, 0.05 mmol, 1.0 eq) in DCM (1.5 mL) was added HC1 (4 M in dioxane) (0.8 mL). The mixture was stirred at RT for 1 hour. The reaction mixture was concentrated. The residue was purified by preparative HPLC (Phenomenex Synergi C18 150 mm x 25mm x 10pm, water with FA-ACN) to give l-[3- acetyl-6-[5-[(6-pyrrolidin-2-ylpyridazin-3-yl)amino]benzimid azol-l-yl]-2-pyridyl]-5-methyl- pyrazole-3 -carbonitrile (20 mg, 0.04 mmol, 78% yield) as an off white solid. LC-MS: m/z = 505.2 [M+H]+, ESI pos.

Step 4: l-[3-acetyl-6-[5-[[ 6-[ l-(oxetan-3-yl)pyrrolidin-2-yl]pyridazin-3- yl amino ]benzimidazol-l-yl / -2 -pyridyl ]-5-methyl-pyrazole-3-carbonitrile

A solution of NaBH ₃ CN (9 mg, 0.14 mmol, 3.02 eq) and 3-oxetanone (11 mg, 0.15 mmol, 3.16 eq) in MeOH (2 mL) was stirred at 30 °C for 0.5 hour. l-[3-acetyl-6-[5-[(6-pyrrolidin-2- ylpyridazin-3-yl)amino]benzimidazol-l-yl]-2-pyridyl]-5-methy l-pyrazole-3- carbonitrile;hydrochloride (25 mg, 0.05 mmol, 1.0 eq) was added and the mixture was stirred at 30 °C for 12 hours. The reaction mixture was concentracted. The residue was purified by preparative TLC (DCM:MeOH 10: 1) to give l-[3-acetyl-6-[5-[[6-[l-(oxetan-3-yl)pyrrolidin-2- yl]pyridazin-3-yl]amino]benzimidazol-l-yl]-2-pyridyl]-5-meth yl pyrazole-3 -carbonitrile (20 mg, 0.04 mmol, 77% yield) as light yellow solid. LC-MS: m/z = 561.2 [M+H]+, ESI pos.

Step 5: l-[ 3-( I -hydroxyethyl)-6-[5-[[ 6-[ l-(oxetan-3-yl)pyrrolidin-2-yl ]pyridazin-3- yl amino ]benzimidazol-l-yl / -2 -pyridyl ]-5-methyl-pyrazole-3-carbonitrile

To a solution of l-[3-acetyl-6-[5-[[6-[l-(oxetan-3-yl)pyrrolidin-2-yl]pyridaz in-3- yl]amino]benzimidazol-l-yl]-2-pyridyl]-5-methyl-pyrazole-3-c arbonitrile (20 mg, 0.04 mmol, 1.0 eq) in MeOH (2.5 mL) was added sodium borohydride (4 mg, 0.11 mmol, 3.0 eq) at 0 °C . The reaction mixture was stirred at 0 °C for 1 hour. The reaction mixture was diluted with sat. aq. NH4CI (5 mL) at 0 °C and extracted with EtOAc (2 x 10 ml). The combined organic layers were dried over Na2SO4, filtered and concentracted. The residue was purified by preparative HPLC (Phenomenex Synergi C18 150 mm x 25mm x 10pm, water with FA-ACN) to give l-[3- (l-hydroxyethyl)-6-[5-[[6-[l-(oxetan-3-yl)pyrrolidin-2-yl]py ridazin-3-yl]amino]benzimidazol-l- yl]-2-pyridyl]-5-methyl-pyrazole-3-carbonitrile (5 mg, 0.01 mmol, 22% yield) as an off white solid. LC-MS: m/z = 563.2 [M+H]+, ESI pos. 'H NMR (400 MHz, METHANOL-d4) 5 = 9.22 (s, 1H), 8.75 (d, J = 5.0 Hz, 1H), 8.58 (d, J= 8.4 Hz, 1H), 8.36 - 8.31 (m, 1H), 8.27 - 8.22 (m, 2H), 8.05 - 8.01 (m, 1H), 7.59 - 7.55 (m, 1H), 6.91 - 6.89 (m, 1H), 4.84 - 4.77 (m, 2H), 4.71 - 4.67 (m, 1H), 4.55 (t, J= 6.4 Hz, 1H), 4.16 - 4.08 (m, 1H), 2.93 - 2.65 (m, 2H), 2.44 - 2.33 (m, 5H), 2.13 - 1.98 (m, 4H), 1.45 - 1.42 (m, 3H).

Examples 277-279, 281, 283-285, 289, 313, 315, 316, 332, 335, 346, 349, 356, 363, 386, 396,

399

In analogy to Example 76, Examples in the following table were prepared, using the respective building blocks A.X (A.l to A.20) and B.X (B.l to B.3) in step 3.

Building block A.l: l-(2,2-difluorocyclopropyl)-5-methyl-4-(4,4,5,5-tetramethyl- l,3,2- dioxaborolan-2-yl)pyrazole and l-(2,2-difluorocyclopropyl)-3-methyl-4-(4,4,5,5-tetramethyl- 1, 3, 2-dioxaborolan-2-yl)pyrazole

A mixture of 2-bromo-l,l-difluoro-cyclopropane (151 mg, 0.96 mmol, 2.0 equiv.), 3-methyl-4- (4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2-yl)-lH-pyrazole (100 mg, 0.48 mmol, 1.0 equiv.), CS2CO3 (313 mg, 0.96 mmol, 2.0 equiv.) and DMF (2 mL) was stirred at 120 °C for 12 hours. The reaction mixture was cooled to RT, diluted with water (10 mL) and extracted with EtOAC (3 x 10 mL). The combined organic layers were washed with brine (15 mL), dried over anhydrous ISfeSCU, filtered and concentrated. The crude was purified by flash chromatography (SiCL, 10 % EtOAc in petroleum ether) to give a mixture of l-(2,2-difluorocyclopropyl)-5- methyl-4-(4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2-yl)pyrazo le and l-(2,2-difluorocyclopropyl)- 3-methyl-4-(4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2-yl)pyra zole (120 mg, 0.42 mmol, 89% yield) as a yellow oil. LC-MS: m/z = 284.8 [M+H]+, ESI pos. Building blocks A.2 andA.3: l-(2-methoxypropyl)-5-methyl-4-(4,4,5,5-tetramethyl-l,3,2- dioxaborolan-2-yl)pyrazole and l-(2-methoxypropyl)-3-methyl-4-(4, 4, 5,5-tetramethyl-l, 3, 2- dioxaborolan-2-yl)pyrazole

Step 1: l-(4-bromo-5-methyl-pyrazol-l-yl)propan-2-ol and l-(4-bromo-3-methyl-pyrazol-l- yl)propan-2-ol

To a solution of 4-bromo-3 -methyl pyrazole (4.0 g, 24.84 mmol, 1.0 equiv.) in DMF (50 mL) was added l-chloro-2-propanol (3.52 g, 37.27 mmol, 1.5 equiv.) and CS2CO3 (16.19 g, 49.69 mmol, 2.0 equiv.). The mixture was stirred at 100 °C for 12 hours. The mixture was diluted with water (100 mL), extracted with EtOAc (2 x 100 mL). The combined organic layers were washed with brine, dried over with anhydrous ISfeSCU and concentrated under reduced pressure to give a mixture of l-(4-bromo-5-methyl-pyrazol-l-yl)propan-2-ol and l-(4-bromo-3-methyl-pyrazol-l- yl)propan-2-ol (5.0 g, 22.82 mmol, 83% yield) as yellow oil which was used without further purification. LC-MS: m/z = 219.0 [M+H]+, ESI pos.

Step 2: 4-bromo-l-(2-methoxypropyl)-5-methyl-pyrazole and 4-bromo-l-(2-methoxypropyl)-3- methyl-pyrazole

To a solution of l-(4-bromo-3-m ethyl -pyrazol-l-yl)propan-2-ol (1.0 g, 4.56 mmol, 1.0 equiv.) in DMF (10 mL) was added NaH (365 mg, 9.13 mmol, 2.0 equiv.) at 0 °C. The mixture was stirred at 0 °C for 30 minutes. lodomethane (1.42 mL, 22.82 mmol, 5.0 equiv.) was added. The mixture was stirred at 20 °C for 0.5 h. The mixture was diluted with water (50 mL), extracted with EtOAc (3 x 50 mL). The combined organic layers were washed with brine, dried over with Na2SO4 and concentrated under reduced pressure to give a mixture of 4-bromo-l-(2- methoxypropyl)-5-methyl-pyrazole and 4-bromo-l-(2-methoxypropyl)-3 -methyl -pyrazole (1.2 g, 5.15 mmol, 96% yield) as yellow oil which was used without further purification. LC-MS: m/z = 235.3 [M+H]+, ESI pos. Step 3: l-(2-methoxypropyl)-5-methyl-4-(4, 4, 5, 5-tetramethyl-l, 3, 2-dioxaborolan-2-yl)pyrazole and l-(2-methoxypropyl)-3-methyl-4-(4, 4, 5, 5-tetramethyl-l, 3, 2-dioxaborolan-2-yl)pyrazole

To a solution of bis(pinacolato)diboron (2.72 g, 10.72 mmol, 2.5 equiv.) and a mixture of 4- bromo-l-(2-methoxypropyl)-5-methyl-pyrazole and 4-bromo-l-(2-methoxypropyl)-3 -methyl - pyrazole (1.0 g, 4.29 mmol, 1.0 equiv.) in di(ethylene glycol)dimethyl ether (10 mL) was added tri cyclohexyl phosphine (241 mg, 0.86 mmol, 0.2 equiv.) and water (0.050 mL). The mixture was bubbled with N2 for about 10 minutes. Pd(II)(OAc)2 (1.5 mg, 0.010 mmol, 0.10 equiv.) was added and the mixture was stirred under N2 at 100 °C for 3 hours. The crude was purified by flash chromatography (SiCL, 10 % EtOAc in petroleum ether) to give a mixture of l-(2- methoxypropyl)-5-methyl-4-(4, 4, 5, 5-tetramethyl-l, 3, 2-dioxaborolan-2-yl)pyrazole and l-(2- methoxypropyl)-3 -m ethyl -4-(4, 4, 5, 5-tetramethyl-l, 3, 2-dioxaborolan-2-yl)pyrazole (880 mg, 3.14 mmol, 36% yield) as brown oil. LC-MS: m/z = 281.3 [M+H]+, ESI pos.

Building blocks A.4 and A.6: l-(2,2-difhioropropyl)-3-methyl-4-(4, 4, 5, 5-tetramethyl-l, 3,2- dioxaborolan-2-yl)pyrazole and l-(2, 2 -difluor opr opyl)-5-methyl-4-(4, 4, 5, 5-tetramethyl-l, 3, 2- dioxaborolan-2-yl)pyrazole

Building blocks A.4 and A.6 was synthesized in analogy to Building block A.l using 2,2- difluoropropyl trifluoromethanesulfonate to give a mixture of l-(2,2-difluoropropyl)-3-methyl-4- (4, 4, 5, 5-tetramethyl-l, 3, 2-dioxaborolan-2-yl)pyrazole and l-(2,2-difluoropropyl)-5-methyl-4- (4, 4, 5, 5-tetramethyl-l, 3, 2-dioxaborolan-2-yl)pyrazole which was used without further purification. LC-MS: m/z = 287.2 [M+H]+, ESI pos.

Building block A.5: 2-ethyl-5-methyl-4-(4, 4, 5, 5-tetramethyl-l, 3, 2-dioxaborolan-2-yl)pyridine

CAS: 2223045-66-5 Building block A. 7: 2-methoxy-5-methyl-4-(4, 4, 5, 5-tetramethyl-l, 3, 2-dioxaborolan-2- yl)pyridine

CAS: 2246720-33-0 Building block A.8: 2-cyclopropyl-5-methyl-4-( 4, 4, 5, 5-tetramethyl-l , 3, 2-dioxaborolan-2- yl)pyridine

CAS: 2223028-93-9 Building block A.9: l-(2, 2 -difluor oethyl)-3-methyl-4-( 4, 4, 5, 5 -tetr ame thy l-l , 3, 2-dioxaborolan-2- yl)pyrazole

Building block A.9 was synthesized in analogy to Building block A.l using 2,2-difluoroethyl trifluoromethanesulfonate to give l-(2,2-difluoroethyl)-3-methyl-4-(4, 4, 5, 5-tetramethyl-l, 3,2- dioxaborolan-2-yl)pyrazole. LC-MS: m/z = 273.4 [M+H]+, ESI pos.

Building blocks A.10 and A.ll: 3-methyl-4-(4, 4, 5, 5-tetramethyl-l, 3, 2-dioxaborolan-2-yl)-l- (2, 2, 2 -trifluor oethyl)pyrazole and 5-methyl-4-( 4, 4, 5, 5-tetramethyl-l , 3, 2-dioxaborolan-2-yl)-l- (2, 2, 2-trifluoroethyl)pyrazole

Step 1: 4-bromo-3-methyl-l-(2,2,2-trifluoroethyl)pyrazole and 4-bromo-5-methyl-l-(2,2,2- trifluoroethyl)pyrazole

A mixture of 4-bromo-3 -methyl pyrazole (15.0 g, 93.17 mmol, 1.0 equiv.), 2,2,2-trifluoroethyl trifluoromethanesulfonate (22.71 g, 97.83 mmol, 1.05 equiv.) and CS2CO3 (25.33 g, 186.34 mmol, 2.0 equiv.) in DMF (150 mL) was stirred at 100 °C for 12 hours. The reaction mixture was cooled and filtered. The filtrate was diluted with H2O (250 mL) and extracted with EtOAc (3 x 250 mL). The combined organic layers were washed with brine (250 mL), dried over anhydrous ISfeSCU, filtered and concentrated. The crude was purified by flash chromatography (SiCL, 0-20 % EtOAc in petroleum ether) to give a mixture of 4-bromo-3 -methyl- 1 -(2,2,2- trifluoroethyl)pyrazole and 4-bromo-5-methyl-l-(2,2,2-trifluoroethyl)pyrazole (19.5 g, 80.24 mmol, 86% yield) as colorless oil which was used without further purification. LC-MS: m/z = 242.9 [M+H]+, ESI pos.

Step 2: 3-methyl-4-(4, 4, 5, 5-tetramethyl-l, 3, 2-dioxaborolan-2-yl)-l-(2, 2, 2-trifhioroethyl)pyrazole and 5-methyl-4-(4, 4, 5, 5-tetramethyl-l, 3, 2-dioxaborolan-2-yl)-l-(2, 2, 2-trifhioroethyl)pyrazole

To a mixture of 4-bromo-3-methyl-l-(2,2,2-trifluoroethyl)pyrazole and 4-bromo-5-methyl-l- (2,2,2-trifhioroethyl)pyrazole (11.0 g, 45.26 mmol, 1.0 equiv.), KOAc (8.88 g, 90.53 mmol, 2.0 equiv.) and bis(pinacolato)diboron (13.79 g, 54.32 mmol, 1.2 equiv.) in 1,4-dioxane (200 mL) was added Pd(dppf)C12.CH2C12 (3.7 g, 4.53 mmol, 0.1 equiv.). The mixture was stirred at 100 °C for 16 hours under N2. The mixture was cooled and concentrated under reduced pressure. The residue was purified by flash chromatography (SiCL, 10-20 % EtOAc in petroleum ether) to give a mixture of 3-methyl-4-(4, 4, 5, 5-tetramethyl-l, 3, 2-dioxaborolan-2-yl)-l-(2, 2,2- trifluoroethyl)pyrazole and 5-methyl -4-(4, 4, 5, 5-tetramethyl-l, 3, 2-dioxaborolan-2-yl)-l -(2,2,2- trifhioroethyl)pyrazole (9.0 g, 31 mmol, 69% yield) as yellow gum. LC-MS: m/z = 291.1 [M+H]+, ESI pos.

Building block A.12: 5-methyl-4-(4, 4, 5, 5-tetramethyl-l, 3, 2-dioxaborolan-2-yl)-2- ( trifluoromethyl)pyridine

CAS: 2170501-97-8

Building block A.13: 2-(difluoromethyl)-5-methyl-4-( 4, 4, 5, 5 -tetr ame thy l-l , 3, 2-dioxaborolan-2- yl)pyridine

CAS: 2632985-01-2

Building block A.14: 2-(difluoromethoxy)-5-methyl-4-( 4, 4, 5, 5 -tetr ame thy I- 1 , 3, 2-dioxaborolan- 2-yl)pyridine A mixture of 4-bromo-2-(difluoromethoxy)-5-methyl-pyridine (1805592-30-6) (400 mg, 1.68 mmol, 1.0 equiv.), bis(pinacolato)diboron (1707 mg, 6.72 mmol, 4.0 equiv.), KO Ac (330 mg, 3.36 mmol, 2.0 equiv.) and [l,r-bis(diphenylphosphino)ferrocene]palladium(II) chloride (137 mg, 0.17 mmol, 0.1 equiv.) in 1,4-dioxane (20 mL) was stirred at 80 °C under N2 atmosphere for 2 hours. The reaction mixture was cooled and filtered. The filtrate was concentrated and the residue was purified by flash chromatography (SiO2, 10-50 % EtOAc in petroleum ether) to give 2-(difluoromethoxy)-5-methyl-4-(4,4,5,5-tetramethyl-l,3,2-di oxaborolan-2-yl)pyridine (433 mg, 1.52 mmol, 90% yield) as a yellow solid. LC-MS: m/z = 286.1 [M+H]+, ESI pos.

Building block A.15: 4-methyl-3-(4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2-yl)-l-( 2,2,2- trifhioroethyl)pyrazole

Building block A.15 was synthesized in analogy to Building block A.10 and A.ll using 3- bromo-4-methyl-lH-pyrazole in step 1 to give 4-methyl-3-(4, 4, 5, 5-tetramethyl-l, 3, 2- dioxaborolan-2-yl)-l-(2,2,2-trifluoroethyl)pyrazole. LC-MS: m/z = 209.1 [M+H]+, ESI pos.

Building block A.16: l-(cyclopropylmethyl)-3-methyl-4-( 4, 4, 5, 5-tetramethyl-l , 3, 2- dioxaborolan-2-yl)pyrazole

CAS: 1353003-17-4

Building block A.17: l-(difluoromethyl)-4-methyl-3-(4, 4, 5, 5-tetramethyl-l, 3, 2-dioxaborolan-2- yl)pyrazole

To a solution of 4-methyl-3-(4, 4, 5, 5-tetramethyl-l, 3, 2-dioxaborolan-2-yl)-lH-pyrazole (500 mg, 2.4 mmol, 1.0 equiv.) and diethyl(bromodifluoromethyl)phosphonate (1.28 g, 4.81 mmol, 2.0 equiv.) in ACN (10 mL) was added KF (419 mg, 7.21 mmol, 3.0 equiv.). The mixture was stirred at 50 °C for 12 hours. The mixture was diluted with DCM (30 mL) and filtered. The filtrate was washed by saturated aqueous NaHCCL (20mL) and saturated aqueous NH4CI (20 mL). The organic layer was dried over Na2SO4, filtered and concentrated to give 1- (difhioromethyl)-4-methyl-3-(4, 4, 5, 5-tetramethyl-l, 3, 2-dioxaborolan-2-yl)pyrazole (120 mg, 0.46 mmol, 17% yield) as brown gum which was used without further purification. ^J H NMR (400 MHz, CDCI3) 8 = 7.61 (s, 1H), 7.26 (t, 1H), 2.25 (s, 3H), 1.37 (s, 12H).

Building block A.18: 3-fluoro-4-( 4, 4, 5, 5 -tetr ame thy l-l , 3, 2-dioxaborolan-2-yl)-l-(2, 2, 2- trijluoroethyl)pyridin-2-one

Step 1: 4-bromo-3-fluoro-lH-pyridin-2-one

A mixture of 4-bromo-2, 3 -difluoro-pyridine (5.0 g, 25.78 mmol, 1.0 equiv.) in acetic acid (50 mL) and H2O (25 mL) was stirred at 110 °C for 32 hours. The mixture was concentrated under vacuo and the residue was neutralized with aq. NaHCCh (150 mL) and extracted with EtOAc (3 x 100 mL). The combined organic layers were dried over Na2SO4, filtered and concentrated to give 4-bromo-3-fluoro-lH-pyridin-2-one (4.76 g, 24.79 mmol, 94% yield) as white solid which was used without further purification. LC-MS: m/z = 191.9 [M+H]+, ESI pos.

Step 2: 4-bromo-3-jluoro-l-(2,2,2-trifluoroethyl)pyridin-2-one

To a solution of 4-bromo-3-fluoro-lH-pyridin-2-one (4.76 g, 24.79 mmol, 1.0 equiv.) in THF (100 mL) was added dropwise LiHMDS (1 M in THF) (49.6 mL, 49.59 mmol, 2.0 equiv.) at 0 °C under N2 and the reaction mixture was stirred at 0 °C for 1 hour under N2. 2,2,2-trifluoroethyl trifluoromethanesulfonate (11.51 g, 49.59 mmol, 2.0 equiv.) in THF (50 mL) was added dropwise and the mixture was warmed to RT over 30 minutes. The mixture was heated to 70 °C and stirred for another 16 hours. The mixture was diluted with saturated NH4CI (200 mL) and extracted with EtOAc (3 x 100 mL). The combined organic layers were washed with brine (50 mL), dried over Na2SO4, filtered and concentrated. The crude was purified by flash chromatography (SiO2, 40 % EtOAc in petroleum ether) to afford 4-bromo-3 -fluoro- 1 -(2,2,2- trifhioroethyl)pyridin-2-one (5.95 g, 21.71 mmol, 85% yield) as light brown solid. LC-MS: m/z = 275.8 [M+H]+, ESI pos. 'H NMR (400 MHz, CDCI3) 8 = 7.01 (br d, J= 7.5 Hz, 2H), 6.40 (dd, J= 5.6, 7.5 Hz, 2H), 4.63 (q, J= 8.4 Hz, 4H).

Step 3: 3-fluoro-4-(4, 4, 5, 5-tetramethyl-l , 3, 2-dioxaborolan-2-yl)-l-(2, 2, 2 -trifluor oethyl)pyridin- 2-one

To a solution of 4-bromo-3-fluoro-l-(2,2,2-trifluoroethyl)pyridin-2-one (2.0 g, 7.3 mmol, 1.0 equiv.) and bis(pinacolato)diboron (3.71 g, 14.6 mmol, 2.0 equiv.) in DMSO (20 mL) was added Pd(dppf)C12 (533 mg, 0.73 mmol, 0.1 equiv.). The reaction mixture was bubbled with N2 for 10 minutes. KO Ac (1.43 g, 14.6 mmol, 2.0 equiv.) was added and the mixture was stirred at 100 °C for 1 hour under N2. The mixture was cooled and poured into water (100 mL). The brown precipitate was filtered out and the filtrate was extracted with EtOAc (5 x 50 mL). The combined organic layers were washed with brine (50 mL), dried over ISfeSCU, filtered and concentrated. The crude was purified by flash chromatography (SiCh, 50 % EtOAc in petroleum ether) to give 3-fluoro-4-(4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2-yl)-l-( 2,2,2-trifluoroethyl)pyridin-2-one (1.4 g, 4.36 mmol, 60% yield) as white solid. LC-MS: m/z = 240.0 [M+H]+, ESI pos. ’H NMR (400 MHz, CDC1 ₃ ) 8 = 7.04 (d, J= 7.0 Hz, 1H), 6.34 (dd, J = 4.6, 7.0 Hz, 1H), 4.64 (q, J = 8.4 Hz, 2H), 1.36 (s, 12H).

Building block A.19: 6-(difluoromethoxy)-3-methyl-4-( 4, 4, 5, 5 -tetr ame thy l-l , 3, 2-dioxaborolan- 2-yl)pyridazine

Step 1: 3,4-dichloro-6-(difluoromethoxy)pyridazine

To a solution of 3,4-dichloro-lH-pyridazin-6-one (9.0 g, 54.55 mmol, 1.0 equiv.) in ACN (100 mL) was added 2,2-difluoro-2-(fluorosulfonyl)acetic acid (19.43 g, 109.1 mmol, 2.0 equiv.). The reaction mixture was stirred at 80 °C for 16 hours to give a white suspension. The reaction mixture was cooled to RT and filtered. The filtrate was concentrated and the residue was purified by flash chromatography (SiCh, 0-10 % EtOAc in petroleum ether) to give 3,4-dichloro-6- (difluoromethoxy)pyridazine (2.7 g, 12.56 mmol, 23% yield) as a light yellow oil. LC-MS: m/z = 215.1 [M+H]+, ESI pos.

Step 2: 4-chloro-6-(difhioromethoxy)-3-methyl-pyridazine

To a solution of 3,4-dichloro-6-(difluoromethoxy)pyridazine (1.7 g, 7.91 mmol, 1.0 equiv.) in 1,4-dioxane (20 mL) was added ISfeCOs (2.5 g, 23.59 mmol, 2.98 equiv.), trimethylboroxine (2.0 g, 7.97 mmol, 1.01 equiv.) and Pd(dppf)C12*DCM (645 mg, 0.79 mmol, 0.1 equiv.) and H2O (2 mL). The mixture was bubbled with N2 for 10 minutes. The reaction mixture was stirred at 90 °C under N2 for 3 hours. The reaction mixture was cooled to RT, poured under stirring into saturated aqueous NH4CI (200 ml) and extracted with EtOAc (3 x 50 mL). The combined organic layers were washed with brine (50 mL), dried over Na2SO4, filtered and concentrated. The residue was purified by flash chromatography (SiO2, 0-10 % EtOAc in petroleum ether) to give 4-chloro-6-(difluoromethoxy)-3-methyl-pyridazine (1.3 g, 6.68 mmol, 84% yield) as a white solid. LC-MS: m/z = 195.0 [M+H]+, ESI pos.

Step 3: 6-(difluoromethoxy)-3-methyl-4-(4, 4, 5, 5-tetramethyl-l, 3, 2-dioxaborolan-2-yl)pyridazine

To a solution of 4-chloro-6-(difluoromethoxy)-3-methyl-pyridazine (100 mg, 0.51 mmol, 1.0 equiv.) in 1,4-dioxane (1 mL) was added Pd2(dba)s (47 mg, 0.05 mmol, 0.1 equiv.), bis(pinacolato)diboron (196 mg, 0.77 mmol, 1.5 equiv.), Xphos (49 mg, 0.1 mmol, 0.2 equiv.) and KOAc (152 mg, 1.55 mmol, 3.0 equiv.) at 20 °C. The mixture was bubble with N2 for 10 minutes. The reaction mixture was stirred at 100 °C for 3 hours under N2. Thiourea on resin (100 mg) was added and the mixture was stirred at RT for 5 minutes. The mixture was filtered and the filtrate was concentrated to give 6-(difluoromethoxy)-3-methyl-4-(4, 4,5, 5-tetramethyl-l, 3,2- dioxaborolan-2-yl)pyridazine (100.0 mg, 0.35 mmol, 68.01% yield) as a brown liquid which was used without further purification. LC-MS: m/z = 205.1 [M+H]+ (boronic acid), ESI pos.

Building block A.20: l-(2,3-difluoropropyl)-3-methyl-4-(4, 4, 5, 5-tetramethyl-l, 3,2- dioxaborolan-2-yl)pyrazole

Step 1: 4-bromo-3-methyl-l-(oxiran-2-ylmethyl)pyrazole

To a solution of 4-bromo-3-m ethyl pyrazole (5.0 g, 31.06 mmol, 1.0 equiv.) in ACN (100 mL) were added 2-(bromomethyl)oxirane (4.25 g, 31.06 mmol, 1.0 equiv.) and K2CO3 (12.88 g, 93.17 mmol, 3.0 equiv.). The mixture was stirred at 50 °C for 16 hours. The mixture was cooled to RT, filtered and the filtrate was concentrated. The crude was purified by flash chromatography (SiCL, 0-20 % EtOAc in petroleum ether) to give 4-bromo-3 -methyl- l-(oxiran-2- ylmethyl)pyrazole (4.5 g, 20.73 mmol, 67% yield) as colorless oil. LC-MS: m/z = 217.1 [M+H]+, ESI pos.

Step 2: 3-(4-bromo-3-methyl-pyrazol-l-yl)-2-fhioro-propan-l-ol

To a solution of 4-bromo-3 -methyl- l-(oxiran-2-ylmethyl)pyrazole (500 mg, 2.3 mmol, 1.0 equiv.) in THF (5 mL) was added tetrabutylammonium fluoride (25.34 mL, 25.34 mmol, 11.0 equiv.) dropwise. The reaction mixture was stirred at 90 °C for 16 hours. The mixture was cooled to RT, poured into water (10 mL) and extracted with EtOAc (3 x 10 mL). The combined organic layers were washed with brine (20 mL), dried over Na2SO4, filtered and concentrated under reduced pressure. The crude was purified by flash chromatography (SiCh, 0-10 % EtOAc in petroleum ether) to give 3-(4-bromo-3-methyl-pyrazol-l-yl)-2-fluoro-propan-l-ol (400 mg, 1.69 mmol, 73% yield) as colorless oil. LC-MS: m/z = 237.0 [M+H]+, ESI pos.

Step 3: 4-bromo-l-(2,3-difluoropropyl)-3-methyl-pyrazole

To a solution of 3-(4-bromo-3-methyl-pyrazol-l-yl)-2-fluoro-propan-l-ol (2.6 g, 10.97 mmol, 1.0 equiv.) in toluene (40 mL) was added DAST (3.62 mL, 27.42 mmol, 2.5 equiv.) dropwise at 0 °C under N2. The mixture was warmed to RT and stirred for 5 minutes. Pyridine (3.0 mL, 37.09 mmol, 3.38 equiv.) was added to the reaction mixture. The reaction mixture was stirred at 70 °C for 16 hours. The mixture was cooled to RT, poured into saturated NaHCCL (100 mL) and extracted with EtOAc (3 x 60 mL). The combined organic layers were washed with brine (50 nL), dried over Na2SO4, filtered and concentrated. The crude was purified by preparative HPLC (Phenomenex luna C18 150 x 40mm x 15pm, water with FA-ACN) to give 4-bromo-l-(2,3- difluoropropyl)-3-methyl-pyrazole (1.4 g, 5.86 mmol, 53.4% yield)) as brown oil. LC-MS: m/z = 239.2 [M+H]+, ESI pos. 'H NMR (400 MHz, CDCI3) 8 = 7.57 - 7.39 (m, 1H), 5.19 - 4.89 (m, 1H), 4.85 - 4.34 (m, 4H), 2.39 - 2.21 (m, 3H).

Step 4: l-(2, 3-difluoropropyl)-3-methyl-4-(4, 4, 5, 5-tetramethyl-l, 3, 2-dioxaborolan-2-yl)pyrazole

To a solution of 4-bromo-l -(2,3 -difluoropropyl)-3-m ethyl -pyrazole (1.00 g, 4.18 mmol, 1.0 equiv.) in 1,4-dioxane (40 mL) were added bis(pinacolato)diboron (2.124 g, 8.37 mmol, 2.0 equiv.), l,l'-bis(diphenylphosphino)ferrocenepalladium(II)di chloride (344 mg, 0.42 mmol, 0.1 equiv.) and KOAc (1.232 g, 12.55 mmol, 3.0 equiv.). The mixture was bubbled with N2 for 10 minutes. The mixture was stirred at 100 °C for 16 hours. The reaction mixture was cooled to RT, poured into H2O (50 mL) and extracted with EtOAc (3 x 40 mL). The combined organic layers were washed with brine (2 x 20 mL), dried over Na2SO4, filtered and concentrated. The crude was purified by preparative HPLC (Phenomenex luna Cl 8 150 x 40mm x 15 m, water with FA- ACN) to give 1 -(2,3 -difluoropropyl)-3-m ethyl -4-(4, 4, 5, 5-tetramethyl-l, 3, 2-dioxaborolan-2- yl)pyrazole (270 mg, 0.94 mmol, 14% yield). LC-MS: m/z = 287.1 [M+H]+, ESI pos.

Building block B.1: l-[ 2-chloro-6-[5-[ ( 6-methylpyridazin-3-yl)amino ]benzimidazol-l-yl ]-3- pyridyl ethanone

Building block B.1 was prepared in Example 76, step 2.

Building block B.2: 2-chloro-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-l- yl]pyridine- 3-carbaldehyde

Step 1: 2,6-dichloro-3-(l,3-dioxolan-2-yl)pyridine

In a 250 mL three-necked flask equipped with a Dean-Stark trap, an intensive cooler and a thermometer, 2,6-dichloronicotinaldehyde (3.75 g, 19.2 mmol, 1.0 equiv.) was dissolved in toluene (100 ml). Then, ethane- 1,2-diol (1.8 g, 1.6 ml, 28.7 mmol, 1.5 equiv.) and pTsOH (91.1 mg, 479 pmol, 0.025 eq.) were added. The orange solution was heated to reflux overnight with azeotropic removal of H2O via Dean Stark trap. Once the mixture had cooled down, it was concentrated in vacuum. Residual material was diluted with EtOAc and sat. aq. NaHCOs. The organic layer was separated and washed with H2O. The organic layer was dried with Na2SO4, filtered and evaporated. The crude was purified by flash column chromatography using 0 - 50% EtOAc in heptane as eluent. The title compound 2,6-dichloro-3-(l,3-dioxolan-2-yl)pyridine (3.85 g, 91.3 %) was obtained as a light yellow oil. LC-MS: m/z=220.1 [M+H] ⁺ , ESI pos.

Step 2: l-[ 6-chloro-5-( 1, 3-dioxolan-2-yl)-2-pyridyl ]-N-( 6-methylpyridazin-3-yl)benzimidazol-5- amine

A mixture of N-(6-methylpyridazin-3-yl)-lH-benzimidazol-5-amine (5.12 g, 22.72 mmol, 1.0 eq.), 2,6-dichloro-3-(l,3-dioxolan-2-yl)pyridine (5.0 g, 22.72 mmol, 1.0 equiv.), K2CO3 (6.28 g, 45.44 mmol, 2.0 equiv.) and DMSO (50 mL) was stirred at 60 °C for 24 hours. The reaction mixture was diluted with H2O and extracted with ethyl acetate. The combined organic layers were dried over anhydrous Na2SO4, filtered and concentrated under reduced pressure. The residue was purified by flash column chromatography using 10% MeOH in DCM as eluent to give l-[6-chloro-5-(l,3-dioxolan-2-yl)-2-pyridyl]-N-(6-methylpyri dazin-3-yl)benzimidazol-5- amine (1.0 g, 10.8%) as a brown solid. LC-MS: m/z = 409.1 [M+H] ⁺ , ESI pos.

Step 4: 2-chloro-6-[5-[ ( 6-methylpyridazin-3-yl)amino ]benzimidazol-l-yl ]pyridine-3- carbaldehyde

To a solution of l-[6-chloro-5-(l,3-dioxolan-2-yl)-2-pyridyl]-N-(6-methylpyri dazin-3- yl)benzimidazol-5-amine (600 mg, 1.5 mmol, 1.0 equiv.) in HCl\dioxane (8.0 mL, 32.0 mmol, 21.8 eq.) was added HC1 (8.0 mL, 48.0 mmol, 32.71 equiv.) at 25 °C and the resulting mixture was stirred at 25 °C for 2 hours. The reaction mixture was filtered and the filter cake was dissolved with H2O and lyophilized to give 2-chloro-6-[5-[(6-methylpyridazin-3- yl)amino]benzimidazol-l-yl]pyridine-3-carbaldehyde (530.0 mg, 99.0%) as a yellow solid. LC- MS: m/z = 365.1 [M+H] ⁺ , ESI pos.

Building block B.3: l-[ 2-chloro-6-[ 6-fluoro-5-[ ( 6-methylpyridazin-3-yl)amino ]benzimidazol-l- yl] -3-pyridyl ethanone

A mixture of 6-fluoro-N-(6-methylpyridazin-3-yl)-lH-benzimidazol-5-amine (Example 93 , step 2) (1.70 g, 6.99 mmol, 1.0 equiv.), l-(2,6-dichloro-3-pyridyl)ethanone (1.33 g, 6.99 mmol, 1.0 equiv.) and DIEA (3.64 ,L, 20.97 mmol, 3.0 equiv.) in DMSO (15 mL) was stirred at 130 °C for 12 h. The reaction mixture was cooled to RT and water (100 mL) was added. The reaction mixture was filtered and the filtrate was concentrated. The residue was purified by preparative HPLC(Welch Ultimate XB-SiOH 250 mm x 70 mm x 10 pm ; Gradient: 10% to 55% EtOH in hexane) to give product l-[2-chloro-6-[6-fluoro-5-[(6-methylpyridazin-3- yl)amino]benzimidazol-l-yl]-3-pyridyl]ethanone (1.19 g, 3.01 mmol, 43% yield) as a yellow solid. LC-MS: m/z = 397.2 [M+H] ⁺ , ESI pos. 1H NMR (400 MHz, DMSO-d6) 5 = 9.14 (s, 1H), 8.92 (s, 1H), 8.73 (d, J = 7.7 Hz, 1H), 8.48 (d, J = 8.4 Hz, 1H), 8.23 (d, J = 11.6 Hz, 1H), 8.15 (d, J = 8.4 Hz, 1H), 7.40 - 7.34 (m, 1H), 7.28 (d, J = 9.0 Hz, 1H), 2.68 (s, 3H), 2.54 (br s, 3H).

Examples 275, 282, 293, 294, 297, 302, 307, 314, 317, 319, 333, 337, 345, 347, 348, 353-355, 357, 361, 362, 364, 367, 371-379, 381-385, 388-391, 394, 400, 402, 403

In analogy to Example 65, Examples in the following table were prepared, using the respective building blocks C.X (C.l to C.7) and D.X (D. l to D.8) in step 1 and E.X (E. l to E.19) in step 2.

Building block C.1: 6-Bromo-5-(trifluoromethyl)-lH-benzimidazole

CAS: 1008361-62-3

Building block C.2: 5-bromo-6-(oxetan-3-yloxy)-l~{H}-benzimidazole

Step 1: 4-bromo-2-nitro-5-(oxetan-3-yloxy)aniline

To a solution of oxetan-3-ol (4.26 g, 57.46 mmol, 1.5 eq.) in THF (90 mL) under N2 cooled to 0 °C was added sodium hydride (60% in oil) (2.3 g, 57.61 mmol, 1.5 eq.) in portions and the mixture was stirred at 0 °C for 30 minutes. 4-bromo-5-fluoro-2-nitro-aniline (9.0 g, 38.3 mmol, 1.0 eq.) was added and the reaction mixture was allowed to warm to RT and was stirred at RT for 12 hours. The reaction was quenched with H2O (100 mL) which formed a precipitate. The mixture was filtered and the filter cake was dried under reduced pressure to give 4-bromo-2- nitro-5-(oxetan-3-yloxy)aniline (4.0 g, 13.84 mmol, 36% yield). The filtrate was extracted with EtOAc (3 x 250 mL). The combined organic layers were dried over ISfeSCU, filtered and concentrated. The residue was triturated in a mixture of petrol ether / EtOAc (10: 1, 30 mL) at RT for 30 minutes. The mixture was filtered and the filter cake was dried under reduced pressure to give 4-bromo-2-nitro-5-(oxetan-3-yloxy)aniline (7.0 g, 24.21 mmol, 63% yield) as yellow solid. ESI pos [M+H] ⁺ 289.0. 'H NMR (400 MHz, DMSO-d ₆ ) 5 = 8.16 (s, 1H), 7.56 (s, 2H), 6.21 (s, 1H), 5.31 (q, J= 5.4 Hz, 1H), 4.93 (t, J= 6.8 Hz, 2H), 4.59 (dd, J= 5.2, 7.6 Hz, 2H). Step 2: 4-bromo-5-(oxetan-3-yloxy)benzene-l,2-diamine

To a solution of 4-bromo-2-nitro-5-(oxetan-3-yloxy)aniline (10.5 g, 36.32 mmol, 1.0 eq.) in EtOH (120 mL) under N ₂ was added Fe (10.14 g, 181.61 mmol, 5.0 eq.), NH ₄ C1 (19.43 g, 363.22 mmol, 10.0 eq.) and H2O (40 mL). The reaction mixture was stirred under N2 at 50 °C for 12 hours. The reaction mixture was cooled to RT and filtered. The filtrate was diluted with H2O (100 mL) and extracted with EtOAc (3 x 100 mL). The combined organic layers were concentrated to give 4-bromo-5-(oxetan-3-yloxy)benzene-l,2-diamine (9.4 g, 36.28 mmol, quant, yield) as black solid. ESI pos [M+H] ⁺ 259.0.

Step 3: 5-bromo-6-(oxetan-3-yloxy)-lH-benzimidazole;formic acid

A solution of 4-bromo-5-(oxetan-3-yloxy)benzene-l,2-diamine (9.0 g, 34.74 mmol, 1.0 eq.) and formic acid (8.0 mL, 41463.19 mmol, 1193.68 eq.) in triethyl orthoformate (80 mL) was stirred at 80 °C for 12 hours. The reaction mixture was cooled to RT and concentrated. The residue was purified by preparative HPLC (Phenom enex luna Cl 8 10 pm, 150 mm x 40mm, water + 0.1% FA - ACN) to give 5-bromo-6-(oxetan-3-yloxy)-lH-benzimidazole (8.6 g, 31.96 mmol, 91% yield) as a white solid. ESI pos [M+H] ⁺ 270.9. 'HNMR (400 MHz, CDCI3) 5 = 8.16 (s, 1H), 8.05 (s, 1H), 7.88 (s, 1H), 6.80 (s, 1H), 5.29 (td, J= 5.6, 11.2 Hz, 1H), 5.04 (t, J= 6.8 Hz, 2H), 4.95 - 4.84 (m, 2H).

Building block C.3: 6-Bromo-lH-benzimidazole

CAS: 4887-88-1

Building block C.4: 4- [2- [(6-bromo-3~{H}-benzimidazol-5-yl)oxy] ethyl] morpholine

Step 3: 4-bromo-5-(2-morpholinoethoxy)-2-nitro-aniline

To a solution of 2-morpholinoethanol (614 mg, 4.68 mmol, 1.1 eq) in THF (50 mL) was added NaH (204 mg, 5.1 mmol, 1.2 eq) at 0°C under N2. The reaction mixture was stirred at 0°C for 30min. 4-bromo-5-fluoro-2-nitro-aniline (1.00 g, 4.26 mmol, 1.0 eq) was added at 0°C under N2. The reaction mixture was stirred at 20°C for 14 h. The reaction mixture was poured into sat. aq. NH4CI (300mL) under vigorous stirring and extracted with EtOAc (3 x 200 mL). The combined organic layers were washed with brine (50 mL), dried over ISfeSCU, filtered and concentrated. The residue was purified by flash chromatography (SiCh, 0-10 % MeOH in DCM) to give 4- bromo-5-(2-morpholinoethoxy)-2-nitro-aniline (800 mg, 2.31 mmol, 54% yield) as yellow solid. LC-MS: m/z = 348.1 [M+H]+, ESI pos. 'H NMR (400 MHz, DMSO-d6) 5 = 8.12 (s, 1H), 7.57 (s, 2H), 6.60 (s, 1H), 4.15 (t, J= 5.6 Hz, 2H), 3.59 - 3.53 (m, 4H), 2.75 (t, J= 5.6 Hz, 2H), 2.53 - 2.51 (m, 4H).

Step 3: 4-bromo-5-(2-morpholinoethoxy)benzene-l , 2-diamine

To a solution of 4-bromo-5-(2-morpholinoethoxy)-2-nitro-aniline (650 mg, 1.88 mmol, 1.0 eq) in EtOH (10 mL) was added Fe (524 mg, 9.39 mmol, 5.0 eq), NH4CI (1.00 g, 18.78 mmol, 10 eq) and H2O (3 mL). The reaction mixture was stirred under N2 at 50 °C for 12 h. The reaction mixture was diluted with EtOAc (50mL). The mixture was filtered and the filtrate was added into H2O (20 mL). The aqueous phase was extracted with EtOAc (3 x 30 mL). Combined organic layers were washed with brine (30 mL), dried over Na2SO4, filtered and concentrated to give 4-bromo-5-(2-morpholinoethoxy)benzene-l, 2-diamine (600 mg, 1.9 mmol, 71% yield) as brown oil which was used without further purification. LC-MS: m/z = 316.0 [M+H]+, ESI pos.

Step 3: 4-[ 2-[ ( 6-bromo-lH-benzimidazol-5-yl)oxy ] ethyl morpholine

To a solution of 4-bromo-5-(2-morpholinoethoxy)benzene-l, 2-diamine (500 mg, 1.58 mmol, 1.0 eq) in EtOH (10 mL) were added trimethyl orthoformate (1.73 mL, 15.81 mmol, 10 eq) and TsOH (24 mg, 0.16 mmol, 0.1 eq). The mixture was stirred at 80 °C for 2 h. The reaction mixture was cooled to RT and diluted with sat. aq. NaHCOs (50 ml) and extracted with EtOAc (3 x 30 mL). The combined organic layers were washed with brine (20 mL), dried over Na2SO4, filtered and concentrated to give 4-[2-[(6-bromo-lH-benzimidazol-5-yl)oxy]ethyl]morpholine (500 mg, 1.53 mmol, 97% yield) as yellow solid which was used without further purification. LC-MS: m/z = 328.0 [M+H]+, ESI pos.

Building block C.5: 6-Bromo-5-fluoro-lH-benzimidazole

CAS: 1008360-84-6

Building block C.6: 6-Bromo-5-(difluoromethoxy)-lH-benzimidazole

CAS: 1805750-52-0

Building block C. 7: 6-Bromo-5-methoxy-lH-benzimidazole

CAS: 1008361-65-6

Building block D.l: l-(3-acetyl-6-chloro-2-pyridyl)-5-methyl-pyrazole-3-carbonit rile

Building block D.1 was prepared in Example 64, step 1.

Building block D.2: l-[6-chloro-2-[3-methyl-l-(2,2,2-trifluoroethyl)pyrazol-4-yl ]-3- pyridyl ethanone and l-[ 6-chloro-2-[5-methyl-l-(2, 2, 2-trifhioroethyl)pyrazol-4-yl -3- pyridyl ethanone

A mixture of 3-methyl-4-(4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2-yl)-l-( 2,2,2- trifluoroethyl)pyrazole (Building block A.10) (280 mg, 0.97 mmol, 1.0 eq), 1 -(2-bromo-6- chi oro-3 -pyridyl)ethanone (1256789-68-0) (226 mg, 0.97 mmol, 1.0 eq), K2CO3 (267 mg, 1.93 mmol, 2.0 eq) and Pd(dppf)C12 CH2C12 (79 mg, 0.1 mmol, 0.1 eq) in 1,4-dioxane (4 mL) and H2O (0.400 mL) was stirred at 80 °C under N2 atmosphere for 12 hours. The reaction mixture was cooled to RT and concentrated. The residue was purified by flash chromatography (SiCh, 0- 20 % EtOAc in PE) to give a mixture of l-[6-chloro-2-[5-methyl-l-(2,2,2-trifluoroethyl)pyrazol- 4-yl]-3-pyridyl]ethanone and l-[6-chloro-2-[3-methyl-l-(2,2,2-trifluoroethyl)pyrazol-4-yl ]-3- pyridyl] ethanone (252 mg, 0.79 mmol, 82% yield) (mixture) as yellow oil. LC-MS: m/z = 318.0 [M+H]+, ESI pos.

Building block D.3: l-[6-chloro-2-[3-(difluoromethyl)-5-methyl-pyrazol-l-yl]-3- pyridyl ethanone and l-[ 6-chloro-2-[5-(difluoromethyl)-3-methyl-pyrazol-l-yl -3- pyridyl ethanone

Building block D.3 was prepared in Example 128, step 1.

Building block D.4: l-[6-chloro-2-[3-(difluoromethoxy)-5-methyl-pyrazol-l-yl]-3- pyridyl ethanone

To a colorless solution of 3-(difluoromethoxy)-5-methyl-lH-pyrazole (2108002-48-6) (2.8 g, 18.9 mmol, 1.0 eq)in DMSO (30 mL) was added K2CO3 (7.84 g, 56.71 mmol, 3.0 eq) and l-(6- chloro-2-fluoro-3-pyridyl)ethanone (3.35 g, 18.9 mmol, 1.0 eq). The mixture was stirred at 30 °C for 5 hours. The reaction mixture was poured into H2O (100 mL) and extracted with EtOAc (3 x 50 mL). The combined organic layers were washed with brine (20 mL), dried over Na2SO4, filtered and concentrated. The residue was purified by flash chromatography (SiO2, 10-30 % EtOAc in PE) to give l-[6-chloro-2-[3-(difluoromethoxy)-5-methyl-pyrazol-l-yl]-3- pyridyl] ethanone (1.5 g, 4.97 mmol, 24% yield) as a white solid. LC-MS: m/z = 302.0 [M+H]+, ESI pos. ^J H NMR (400 MHz, CDC1 ₃ ) 8 = 7.81 (d, J= 7.9 Hz, 1H), 7.32 (d, J= 7.9 Hz, 1H), 6.83 (t, J= 72.9 Hz, 1H), 5.92 (s, 1H), 2.61 (s, 3H), 2.17 (s, 3H). Building block D.5: 1 -[6-chloro-2-(3-chloro-5-methyl-pyr azol- l-yl)-3-pyr idyl] ethanone

Building block D.5 was prepared in analogy to Building block D.4 using l-(6-chloro-2-fluoro-3- pyridyl)ethanone (300 mg, 1.73 mmol, 1.0 eq) and 3-chloro-5-methyl-lH-pyrazole (201 mg, 1.73 mmol, 1.0 eq) to give l-[6-chloro-2-(3-chloro-5-methyl-pyrazol-l-yl)-3-pyridyl]eth anone (330 mg, 1.22 mmol, 71% yield) as colorless oil. LC-MS: m/z = 269.8 [M+H]+, ESI pos. 'H NMR (400 MHz, CDC1 ₃ ) 8 = 7.91 (d, J= 7.9 Hz, 1H), 7.40 (d, J= 8.1 Hz, 1H), 6.22 (s, 1H), 2.61 (s, 3H), 2.17 (s, 3H).

Building block D.6: l-(6-chloro-3-formyl-2-pyridyl)-5-methyl-pyrazole-3-carbonit rile

Building block D.6 was prepared in analogy to Building block D.4 using 6-chloro-2-fluoro- pyridine-3-carbaldehyde (1.0 g, 6.27 mmol, 1.0 eq) and 5-methyl-lH-pyrazole-3-carbonitrile (738 mg, 6.89 mmol, 1.1 eq) to give l-(6-chloro-3-formyl-2-pyridyl)-5-methyl-pyrazole-3- carbonitrile (800 mg, 3.24 mmol, 52% yield) as colorless oil. LC-MS: m/z = 247.1 [M+H]+, ESI pos. ^X H NMR (400 MHz, DMSO-d6) 5 ppm 9.80 (s, 1 H) 8.43 (d, J= 8.13 Hz, 1 H) 7.92 (d, J=

8.25 Hz, 1 H) 7.15 (d, J= 0.75 Hz, 1 H) 2.54 (d, J= 0.63 Hz, 3 H).

Building block D.7: methyl 6-chloro-2-[3-(difhioromethyl)-5-methyl-pyrazol-l-yl]pyridin e-3- carboxylate Building block D.7 was prepared in analogy to Building block D.4 using 6-chloro-2-fluoro- nicotinic acid methyl ester (1 g, 5.28 mmol, 1.0 eq) and 3-(difluoromethyl)-5-methyl-lH- pyrazole (836.27 mg, 6.33 mmol, 1.2 eq) to give 6-chloro-2-[3-(difluoromethyl)-5-methyl- pyrazol-l-yl]nicotinic acid methyl ester (943 mg, 3.12 mmol, 59% yield) as colorless oil. LC- MS: m/z = 302.05 [M+H]+, ESI pos. ’H NMR (600 MHz, CDC1 ₃ ) 8 ppm 8.11 (d, J = 8.2 Hz, 1 H), 7.44 (d, J = 8.1 Hz, 1 H), 6.61 (t, J = 55.0 Hz, 1 H), 6.43 (d, J = 0.7 Hz, 1 H), 3.72 (s, 3 H), 2.54 (d, J = 0.7 Hz, 3 H).

Building block D.8: methyl 2-[3,5-bis(difluoromethyl)pyrazol-l-yl]-6-chloro-pyridine-3- carboxylate

Building block D.8 was prepared in analogy to Building block D.4 using 6-chloro-2-fluoro- nicotinic acid methyl ester (250 mg, 1.32 mmol, 1.0 eq) and 3,5-bis(difluoromethyl)-lH-pyrazole (243.84 mg, 1.45 mmol, 1.1 eq) to give 2-[3,5-bis(difluoromethyl)pyrazol-l-yl]-6-chloro- nicotinic acid methyl ester (392 mg, 1.16 mmol, 88% yield) as colorless oil. LC-MS: m/z = 338.0 [M+H]+, ESI pos.

Building block E.l: 3-amino-6-methylpyridazine

CAS: 18591-82-7

Building block E.2:

6-[ 2-[ 2-[ 2-[ 2-[ 2-[ 2-(2-methoxyethoxy)ethoxy ] ethoxy ] ethoxy] ethoxy ] ethoxy ] ethoxy ]pyridazin-3- amine

Step 1: 3-chloro-6-[2-[2-[2-[2-[2-[2-(2- methoxy ethoxy) ethoxy ] ethoxy ] ethoxy] ethoxy] ethoxy ] ethoxy ]pyridazine To a solution of 2,5,8, 11,14, 17, 20-heptaoxadocosan-22-ol (3.0 g, 8.81 mmol, 1.0 eq) in DMF (30 mL) was added NaH (0.6 g, 17.63 mmol, 2.0 eq) at 0 °C. The reaction was stirred at 0°C for 30 minutes. 3,6-dichloropyridazine (1.44 g, 9.69 mmol, 1.1 eq) was added and the reaction mixture was stirred at 25 °C for 16 hours. The reaction mixture was diluted with saturated aqueous NH4CI (50 mL) and extracted with EtOAc (3 x 50 mL), The combined organic layers were washed with brine (20 mL), dried over ISfeSCL, filtered and concentrated. The residue was purified by flash chromatography (SiCh, 10-30 % EtOAc in PE) to give 3-chloro-6-[2-[2-[2-[2- [2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]et hoxy]pyridazine (2.2 g, 4.86 mmol, 55% yield) as yellow oil. LC-MS: m/z = 453.1 [M+H]+, ESI pos. ^J H NMR (400 MHz, CDCI3) 8 ppm 7.39 (d, .7 =9.17 Hz, 1 H) 7.03 (d, .7 =9.17 Hz, 1 H) 4.61 - 4.75 (m, 2 H) 3.87 - 3.94 (m, 2 H) 3.63 - 3.73 (m, 22 H) 3.53 - 3.59 (m, 2 H) 3.35 - 3.41 (m, 3 H).

Step 2: tert-butyl N-[6-[2-[2-[2-[2-[2-[2-(2- methoxyethoxy)ethoxy] ethoxy] ethoxy] ethoxy] ethoxy] ethoxy] pyridazin-3-yl] carbamate

A mixture of 3-chloro-6-[2-[2-[2-[2-[2-[2-(2- methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]pyri dazine (1.0 g, 2.21 mmol, 1.0 eq), tert-butyl carbamate (517 mg, 4.42 mmol, 2.0 eq), CS2CO3 (2.16 g, 6.62 mmol, 3.0 eq) , 9,9- dimethyl-4,5-bis(diphenylphosphino)xanthene (256 mg, 0.44 mmol, 0.2 eq) and tris(dibenzylideneacetone)dipalladium (0) (202 mg, 0.22 mmol, 0.1 eq) in 1,4-dioxane (10 mL) was stirred at 80 °C for 3 h under N2 atmosphere. The mixture was cooled to RT, diluted with H2O (50 mL) and extracted with EtOAc (3 x 50 mL). The combined organic layers were washed with brine (20 mL), dried over Na2SO4, filtered and concentrated. The residue was purified by flash chromatography (SiO2, 100 % EtOAc) to give tert-butyl N-[6-[2-[2-[2-[2-[2-[2-(2- methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]pyri dazin-3-yl]carbamate ()0800 mg, 1.50 mmol, 68% yield). LC-MS: m/z = 534.2 [M+H]+, ESI pos.

Step 3: 6-[2-[2-[2-[2-[2-[2-(2- m ethoxy ethoxy)ethoxy] ethoxy] ethoxy] ethoxy] ethoxy]ethoxy]pyridazin-3 -amine

A mixture of tert-butyl N-[6-[2-[2-[2-[2-[2-[2-(2- m ethoxy ethoxy)ethoxy] ethoxy] ethoxy] ethoxy] ethoxy]ethoxy]pyridazin-3 -yl] carbamate (700 mg, 1.31 mmol, 1.0 eq) in TFA (2.0 mL) and DCM (6 mL) was stirred at 25 °C for 16 hours. The reaction mixture was concentrated. The residue was purified preparative HPLC (Phenomenex luna C18 10 pm, 150 mm x 40mm, water + 0.1% FA - ACN) to give 6-[2-[2-[2-[2-[2-[2-(2- methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]pyri dazin-3-amine (200 mg, 0.46 mmol, 35% yield) as colorless oil. LC-MS: m/z = 434.1 [M+H]+, ESI pos.

Building block E.3: 5 -amino-2 -methylpyridine

CAS: 3430-14-6

Building block E.4: 3-pyridazinamine

CAS: 5469-70-5

Building block E.5: 6-(2-methyl-l,3-dioxolan-2-yl)pyridazin-3-amine

A mixure of l-(6-aminopyridazin-3-yl)ethanone (930600-44-5) (40 mg, 0.29 mmol, 1.0 eq), ethylene glycol (0.05 mL, 0.88 mmol, 3.0 eq) and TosOH (5 mg, 0.03 mmol, 0.1 eq) in toluene (3 mL) was refluxed at 120 °C for 16 hours with azeotropical removal of water. The mixture was cooled to RT, concentrated and the residue was purified by preparative TLC (DCM/MeOH=10/l, Rf=0.4) to give 6-(2-methyl-l,3-dioxolan-2-yl)pyridazin-3-amine (20 mg, 0.11 mmol, 38% yield) as a white solid. LC-MS: m/z = 182.2 [M+H]+, ESI pos. ^J H NMR (400 MHz, acetonitrile-d3) 5 = 7.38 (d, J= 92 Hz, 1H), 6.79 (d, J= 92 Hz, 1H), 5.21 (br s, 2H), 4.06 - 4.01 (m, 2H), 3.92 - 3.87 (m, 2H), 1.68 (s, 3H).

Building block E.6: 3-amino-N,N, 6-trimethyl-pyridazine-4-carboxamide

Step 1: ethyl 3-(benzhydrylideneamino)-6-methyl-pyridazine-4-carboxylate To a solution of ethyl 3-chloro-6-methyl-pyridazine-4-carboxylate (1445-53-0) (1.0 g, 4.98 mmol, 1.0 eq) and benzophenone imine (1.25 mL, 7.48 mmol, 1.5 eq) in 1,4-dioxane (12 mL) were added CS2CO3 (4.87 g, 14.95 mmol, 3.0 eq) and Xantphos Pd G4 (0.48 g, 0.5 mmol, 0.1 eq). The reaction mixture was stirred at 90 °C for 16 hours under N2. The reaction mixture was cooled to RT, poured into water (100 mL) and extracted with EtOAc (3 x 100 mL). The combined organic layers were dried over ISfeSCU, filtered and concentrated. The residue was purified by flash chromatography (SiCh, 40 % EtOAc in PE) to give 3-(benzhydrylideneamino)- 6-methyl-pyridazine-4-carboxylic acid (800 mg, 2.52 mmol, 25% yield) as a yellow solid. LC- MS: m/z = 346.1 [M+H]+, ESI pos. 'H NMR (400 MHz, DMSO-d6) 5 = 7.79 - 7.05 (m, 11H), 4.23 (q, J= 1A Hz, 2H), 2.56 (s, 3H), 1.16 (t, J = 7.1 Hz, 3H).

Step 2: lithium 3-(benzhydrylideneamino)-6-methyl-pyridazine-4-carboxylate

To a mixture of ethyl 3-(benzhydrylideneamino)-6-methyl-pyridazine-4-carboxylate (1.20 g, 3.47 mmol, 1.0 eq) in THF (6 mL), MeOH (6 mL) and H2O (6 mL), was added LiOH (249 mg, 10.42 mmol, 3.0 eq), and the reaction was stirred at 30 °C for 12 hours. The reaction was concentrated to give lithium;3-(benzhydrylideneamino)-6-methyl-pyridazine-4-carbo xylate (1.00 g, 3.09 mmol, 89% yield) as a yellow solid which was used without further purification. LC-MS: m/z = 318.1 [M+H]+, ESI pos.

Step 3: 3-(benzhydrylideneamino)-N,N, 6-trimethyl-pyridazine-4-carboxamide

To a suspension of dimethylamine hydrochloride (324 mg, 3.97 mmol, 1.5 eq) in DMF (10 mL) was added DIPEA (1.38 mL, 7.94 mmol, 3.0 eq), lithium 3-(benzhydrylideneamino)-6-methyl- pyridazine-4-carboxylate acid (840 mg, 2.65 mmol, 1.0 eq), HATU (934 mg, 3.97 mmol, 1.5 eq). The mixture was stirred at 30 °C for 1 hour. The reaction mixture was diluted with H2O (50 mL) and extracted with EtOAc (3 x 20 mL). The combined organic layers were washed with brine (20 mL), dried over Na2SO4, filtered and concentrated. The residue was purified by flash chromatography (SiO2, 30-40 % EtOAc in PE) to give 3-(benzhydrylideneamino)-N,N,6- trimethyl-pyridazine-4-carboxamide (400 mg, 1.16 mmol, 39% yield) as a white solid. LC-MS: m/z = 345.2 [M+H]+, ESI pos. 'H NMR (400 MHz, CDCI3) 8 = 7.84 - 7.22 (m, 11H), 3.06 (s, 3H), 3.02 (s, 3H), 2.61 (s, 3H).

Step 4: 3-amino-N,N, 6-trimethyl-pyridazine-4-carboxamide

To a solution of 3-(benzhydrylideneamino)-N,N,6-trimethyl-pyridazine-4-carbox amide (400 mg, 1.16 mmol, 1.0 eq) in MeOH (20 mL) was added hydroxylamine hydrochloride (161 mg, 2.32 mmol, 2.0 eq), NaOAc (238 mg, 2.9 mmol, 2.5 eq) and the mixture was stirred at 20 °C for 2 hours. The reaction mixture was concentrated. The residue was suspended in H2O (20 mL) and extracted with EtOAc (3 x 10 mL). The combined organic layers were washed by brine (10 mL), dried over Na2SO4, filtered and concentrated. The residue was purified by preparative TLC (EtOAc) to give 3-amino-N,N,6-trimethyl-pyridazine-4-carboxamide (220 mg, 1.22 mmol, 95% yield) as brown solid. . LC-MS: m/z = 181.1 [M+H]+, ESI pos. 'HNMR (400 MHz, CDCI3) 8 = 6.92 (s, 1H), 5.42 (br s, 2H), 3.04 (br s, 3H), 2.94 (br s, 3H), 2.50 (s, 3H).

Building block E. 7: cyclopropanecarboxamide

CAS: 6228-73-5

Building block E.8: 2, 3-difluoro-4-methylbenzenamine

CAS: 886503-79-3

Building block E.9: 2,3,4-trifluoroaniline

CAS: 3862-73-5

Building block E.10: 3-amino-6-chloropyridazine

CAS: 5469-69-2

Building block E.ll: 2-amino-5-methyl-l,3,4-oxadiazole

CAS: 52838-39-8

Building block E.12: 6, 7-dihydro-5H-cyclopenta[c]pyridazin-3-amine

CAS: 1342288-68-9

Building block E.13: 2-amino-5-methyl-l,3,4-thiadiazole

CAS: 108-33-8

Building block E.14: 5-fluoro-6-methyl-3-pyridinamine

CAS: 1211542-12-9

Building block E.15: 5-(l-azetidinyl)-3-pyridazinamine

CAS: 1379254-05-3 Building block E.16: 7, 8-dihydro-5H-pyrano[ 4, 3-c ]pyridazin-3-amine

CAS: 1490340-46-9 Building block E.17: 2-methyl-5-pyrimidinamine

CAS: 39889-94-6

Building block E.18: 3-amino-l-methyl-lH-pyridin-2-one

CAS: 33631-01-5

Building block E.19: 6-(difluoromethyl)pyridazin-3-amine

CAS: 1706450-11-4

Examples 287, 290, 298, 299, 303, 305, 306, 309, 320-326, 329, 331, 344, 359, 360, 393

In analogy to Example 248, Examples in the following table were prepared, using the respective building blocks F.X in step 2. Building block Fl: 3,5-bis(difluoromethyl)-lH-pyrazole

CAS: 77614-79-0

Building block F.2: 3 -(difluor one thy l)pyrrolidine

CAS: 1376435-67-4 Building block F.3: l,l-difluoro-5-azaspiro[2.4]heptane

CAS: 1215166-77-0

Building block F.4: 5-(difluoromethyl)-lH-pyrazole-3-carbonitrile

Step 1: methyl 5-(difluoromethyl)-l-(2-trimethylsilylethoxymethyl)pyrazole- 3-carboxylate

To a solution of methyl 5-(difluoromethyl)-lH-pyrazole-3-carboxylate (1808112-13-1) (580 mg, 3.29 mmol, 1.0 eq) in DMF (6 mL) was added NaH (198 mg, 4.94 mmol, 1.5 eq) at 0 °C under N2 and the mixture was stirred at 0 °C for 15 minutes. 2-(chloromethoxy)ethyl -trimethylsilane (824 mg, 4.94 mmol, 1.5 eq) was added and the mixture was stirred at 25 °C for 16 hours under N2. The mixture was poured into water (30mL) and extracted with EtOAc (2 x 20mL). The combined organic layers were washed by brine (20mL), dried over Na2SO4, filtered and concentrated. The residue was purified by flash chromatography (SiCL, 0-10% EtOAc in PE) to methyl 5-(difluoromethyl)-l-(2-trimethylsilylethoxymethyl)pyrazole- 3-carboxylate (670 mg, 2.19 mmol, 66% yield) as an off-white gum. LC-MS: m/z = 249.3 [M+H]+, ESI pos.

Step 2: 5-(difluoromethyl)-l-(2-trimethylsilylethoxymethyl)pyrazole- 3-carboxamide

A solution of methyl 5-(difhioromethyl)-l-(2-trimethylsilylethoxymethyl)pyrazole- 3-carboxylate (670 mg, 2.19 mmol, 1.0 eq) in ammonia in MeOH (7N) (11 mL) was stirred at 80 °C for 24 hours in a sealed tube. The mixture was concentrated to give 5 -(difluoromethyl)- 1 -(2- trimethylsilylethoxymethyl)pyrazole-3-carboxamide (580 mg, 1.99 mmol, 91% yield) as colorless gum which was used without further purification. LC-MS: m/z = 234.1 [M+H]+, ESI pos.

Step 3: 5-(difluoromethyl)-l-(2-trimethylsilylethoxymethyl)pyrazole- 3-carbonitrile To a solution of 5-(difluoromethyl)-l-(2-trimethylsilylethoxymethyl)pyrazole- 3-carboxamide (200 mg, 0.69 mmol, 1.0 eq) in DCM (4 mL) was added Burgess reagent (491 mg, 2.06 mmol, 3.0 eq). The mixture was stirred at 30 °C for 16 hours under N2. The mixture was concentrated and the residue was purified by flash chromatography (SiCL, 100% PE) to give 5- (difhioromethyl)-l-(2-trimethylsilylethoxymethyl)pyrazole-3- carbonitrile (50 mg, 0.18 mmol, 27% yield) as colorless oil. 'H NMR (400 MHz, CDCI3) 8 = 7.09 (s, 1H), 6.72 (t, J= 54.5 Hz, 1H), 5.61 (s, 2H), 3.64 (t, J= 8.2 Hz, 2H), 0.95 (t, J= 8.2 Hz, 2H), 0.00 (s, 9H).

Step 4: 5-(difluoromethyl)-lH-pyrazole-3-carbonitrile

A solution of 5-(difhioromethyl)-l-(2-trimethylsilylethoxymethyl)pyrazole- 3-carbonitrile (100 mg, 0.37 mmol, 1.0 eq) in TFA (3.0 mL) was stirred at 30 °C for 1 hour. The mixture was diluted with EtOAc (5mL) and concentrated in vacuo to give 5-(difluoromethyl)-lH-pyrazole-3- carbonitrile;2,2,2-trifluoroacetic acid (90 mg, 0.35 mmol, 96% yield) as brown gum which was used without further purification.

Building block F.5: tert-butyl 3-cyano-7, 7-difluoro-4,6-dihydro-lH-pyrazolo[4,3-c]pyridine-5- carboxylate

Step 1: tert-butyl 3, 3-difluoro-4-pyrrolidin-l-yl-2,6-dihydropyridine-l -carboxylate

A mixture of tert-butyl 3,3-difluoro-4,4-dihydroxy-piperidine-l-carboxylate (5.0 g, 19.74 mmol, 1.0 eq) and pyrrolidine (1.63 mL, 19.76 mmol, 1.0 eq) in toluene (65 mL) was refluxed overnight with azeotropic removal of H2O via Dean Stark trap. The reaction mixture was cooled to RT and concentrated to give tert-butyl 3,3-difluoro-4-pyrrolidin-l-yl-2,6-dihydropyridine-l- carboxylate (5.7 g, 19.77 mmol, 100% yield) as yellow solid which was used without further purification. 'H NMR (400 MHz, CDCI3) 6 = 4.47 (br s, 1H), 3.97 (br d, J= 3.5 Hz, 2H), 3.77 (br t, J= 11.5 Hz, 2H), 3.04 (br t, J= 6.1 Hz, 4H), 1.80 (td, J= 3.3, 6.5 Hz, 4H), 1.40 (s, 9H).

Step 2: tert-butyl 5-(2-ethoxy-2-oxo-acetyl)-3, 3-difluoro-4-pyrrolidin-l-yl-2, 6-dihydropyridine- 1-carboxylate A solution of tert-butyl 3,3-difluoro-4-pyrrolidin-l-yl-2,6-dihydropyridine-l-carboxy late (5.7 g, 19.77 mmol, 1.0 eq) in DCM (250 mL) was bubbled with N2 for 10 min. The solution was cooled to 0 °C. Ethyl oxalyl chloride (3.25 g, 23.8 mmol, 1.2 eq) was added dropwise over 15 mineutes while keeping the reaction temperature between 0 °C and 5 °C. TEA (3.93 mL, 28.16 mmol, 1.42 eq) was added dropwise over 5 min. The reaction mixture was stirred at RT for 16 hours. The reaction mixture was diluted with H2O (300 ml) and extracted with DCM (3 x 100 mL). The combined organic layers were dried over ISfeSCL, filtered and concentrated. The residue was purified by flash chromatography (SiCL, 0-25% EtOAc in PE) to give tert-butyl 5-(2- ethoxy-2-oxo-acetyl)-3,3-difluoro-4-pyrrolidin-l-yl-2,6-dihy dropyridine-l-carboxylate (5.6 g, 14.42 mmol, 73% yield) as yellow oil. LC-MS: m/z = 389.1 [M+H]+, ESI pos. 'H NMR (400 MHz, CDCI3) 8 = 4.40 (br s, 2H), 4.29 (q, J = 7.2 Hz, 2H), 3.89 (t, J = 12.2 Hz, 2H), 3.45 (br s, 4H), 1.99 - 1.94 (m, 4H), 1.47 (s, 9H), 1.35 (t, J= 7.2 Hz, 3H)

Step 3: 05-tert-butyl 03-ethyl 7, 7-difluoro-4,6-dihydro-lH-pyrazolo[4,3-c]pyridine-3,5- dicarboxylate

Tert-butyl 5-(2-ethoxy-2-oxo-acetyl)-3,3-difluoro-4-pyrrolidin-l-yl-2,6 -dihydropyridine-l- carboxylate (1.00 g, 2.57 mmol, 1.0 eq) was dissolved in EtOH (20 mL) and cooled to 0 °C. Hydrazine hydrate (140 mg, 2.8 mmol, 1.09 eq) was added dropwise over 5 minutes. The reaction vessel was sealed and the mixture was stirred at 80 °C for 16 hours. The reaction mixture was diluted with H2O (100 ml) and extracted with EtOAc (3 x 50 mL). The combined organic layers were dried over Na2SO4, filtered and concentrated. The residue was purified by flash chromatography (SiO2, 0-50% EtOAc in PE) to give 05-tert-butyl 03-ethyl 7,7-difluoro- 4,6-dihydro-lH-pyrazolo[4,3-c]pyridine-3,5-dicarboxylate (270 mg, 0.81 mmol, 32% yield) as a white solid. LC-MS: m/z = 332.0 [M+H]+, ESI pos.

Step 4: 05-tert-butyl 03-ethyl 7, 7-difluoro-l-(2-trimethylsilylethoxymethyl)-4,6- dihydropyrazolo[ 4, 3-c ]pyridine-3, 5-dicarboxylate

To a solution of 05-tert-butyl 03-ethyl 7,7-difluoro-4,6-dihydro-lH-pyrazolo[4,3-c]pyridine- 3, 5-dicarboxylate (260 mg, 0.78 mmol, 1.0 eq) in DMF (6 mL) was added NaH (38 mg, 0.95 mmol, 1.21 eq) at 0°C. The mixture was stirred at 0 °C for 30 minutes. 2- (trimethylsilyl)ethoxymethyl chloride (0.15 mL, 0.86 mmol, 1.1 eq) was added dropwisea and the mixture was stirred at 0 °C for 4 hours. The reaction mixture was diluted with sat. aq. NH4CI (50 mL) and extracted with EtOAc (3 x 30 mL). The combined organic layers were dried over Na2SO4, filtered and concentrated. The residue was purified by flash chromatography (SiO2, 0- 20% EtOAc in PE) to give 05-tert-butyl 03-ethyl 7,7-difluoro-l-(2-trimethylsilylethoxymethyl)- 4,6-dihydropyrazolo[4,3-c]pyridine-3,5-dicarboxylate (270 mg, 0.58 mmol, 75% yield) as colorless oil.

Step 5: tert-butyl 3-carbamoyl-7, 7 -difluoro- l-(2-trimethylsilylethoxymethyl)-4, 6- dihydropyrazolo[ 4, 3-c ]pyridine-5 -car boxy late

A solution of 05-tert-butyl 03-ethyl 7,7-difluoro-l-(2-trimethylsilylethoxymethyl)-4,6- dihydropyrazolo[4,3-c]pyridine-3,5-dicarboxylate (270 mg, 0.58 mmol, 1.0 eq) in ammonia in MeOH (7N) (6.0 mL) . The reaction mixture was stirred at 80 °C for 60 hours. The reaction mixture was concentrated to give tert-butyl 3-carbamoyl-7,7-difluoro-l-(2- trimethylsilylethoxymethyl)-4,6-dihydropyrazolo[4,3-c]pyridi ne-5-carboxylate (220 mg, 0.51 mmol, 87% yield) as a white solid.

Step 6: tert-butyl 3-cyano-7, 7-dijluoro-l-(2-trimethylsilylethoxymethyl)-4,6- dihydropyrazolo[ 4, 3-c ]pyridine-5-carboxylate

To a solution of tert-butyl 3-carbamoyl-7,7-difluoro-l-(2-trimethylsilylethoxymethyl)-4, 6- dihydropyrazolo[4,3-c]pyridine-5-carboxylate (190 mg, 0.44 mmol, 1.0 eq) in pyridine (5.0 mL) was added trifluoroacetic anhydride (0.26 mL, 1.81 mmol, 4.1 eq) dropwise at 0 °C under N2. The mixture was stirred at 0 °C for 1 hour. The mixture was concentracted and the residue was purified by flash chromatography (SiCh, 0-10% EtOAc in PE) to give tert-butyl 3-cyano-7,7- difluoro-l-(2-trimethylsilylethoxymethyl)-4,6-dihydropyrazol o[4,3-c]pyridine-5-carboxylate (170 mg, 0.41 mmol, 93% yield) as light yellow oil. LC-MS: m/z = 415.8 [M+H]+, ESI pos.

Step 7: tert-butyl 3-cyano-7, 7-dijluoro-4,6-dihydro-lH-pyrazolo[4,3-c]pyridine-5-carboxyl ate

To a solution of tert-butyl 3-cyano-7,7-difluoro-l-(2-trimethylsilylethoxymethyl)-4,6- dihydropyrazolo[4,3-c]pyridine-5-carboxylate (70 mg, 0.17 mmol, 1.0 eq) in THF (2 mL) was added TBAF (IM in THF) (0.84 mL, 0.84 mmol, 5.0 eq) and ethylenediamine (51 mg, 0.85 mmol, 5.0 eq) The mixture was stirred at 60 °C for 3 hours under N2. The reaction mixture was cooled to RT and diluted with saturated aqueous NH4CI (30 ml) and extracted with ethyl acetate (3 x 15 mL). The combined organic layers were dried over Na2SO4, filtered and concentrated. The residue was purified by preparative TLC (SiCh, PE: EtOAc 5:1) to give tert-butyl 3-cyano- 7,7-difluoro-4,6-dihydro-lH-pyrazolo[4,3-c]pyridine-5-carbox ylate (25 mg, 0.09 mmol, 52% yield) as colorless oil. 'H NMR (400 MHz, CDCI3) 8 = 4.62 (br s, 2H), 4.00 (br s, 2H), 1.49 (s, 9H). Building block F.6: 2-(trifluoromethyl)morpholine

CAS: 1196532-95-2

Building block F. 7: 3-azabicyclo [3.1.0] hexane-1 -carbonitrile

CAS: 1422005-81-9

Building block F.8: 5,5-Difluoro-2-azabicyclo[2.2.1]heptane

CAS: 1214875-10-1

Building block F.9: 2 -(difluor ome thy l)mor pholine

CAS: 1242465-34-4

Building block F10: 6, 6-difluoro-2 -azabicyclo [2.2.1 ] heptane

CAS: 1357352-59-0 Building block F.ll: 7 -(difluor omethyl)-5-azaspiro [2.4] heptane

CAS: 2137834-10-5

Building block F.12: 6,6-dijluoro-3-azabicyclo[3.2.0]heptane

CAS: 1214875-41-8

Building block F.13: 1,1 -dimethylethyl 4, 7 -diazaspiro [2.5] octane-4-carboxylate

CAS: 674792-08-6 Building block F.14: 1, 1 -dimethylethyl 2-(trifluoromethyl)-l -piperazinecarboxylate

CAS: 886779-77-7

Building block F.15: 5-(difluoromethyl)-3-methyl-lH-l,2,4-triazole

CAS: 1094760-03-8

Building block F.16: 6-azaspiro[3.4]octane-8-carbonitrile

CAS: 2092409-34-0

Building block F.17: 2-morpholinecarbonitrile

CAS: 135782-24-0

Building block F.18: 1,1 -dimethylethyl 3,3-difluoro-4-hydroxy-l-pyrrolidinecarboxylate

CAS: 1434141-81-7

Building block F.19: 3-(difluoromethoxy)-5-methyl-lH-pyrazole

CAS: 2108002-48-6

Building block F.20: 4,5-Dimethyl-lH-pyrazole-3-carbonitrile

CAS: 2138948-90-8

Examples 291, 292, 295, 296, 310, 312, 318, 327, 328, 330, 334, 336, 338-343, 350-352, 358, 365, 366, 368-370, 380, 387, 392, 395, 397, 398, 401, 404-407

In analogy to Example 64, Examples in the following table were prepared, using the respective building blocks G.X and H.X in step 2.

Building block G.l: N-(6-methylpyridazin-3-yl)-lH-benzimidazol-5-amine

Building block G. l is intermediate 1 in Example 64. Building block G.2: N-(6-methyl-4-methylsulfonyl-pyridazin-3-yl)-l~{H}-benzimida zol-5-amine

Step 1: 3-chloro-6-methyl-4-methylsulfanyl-pyridazine

A solution of 3,4-dichloro-6-methyl-pyridazine (700 mg, 4.29 mmol, 1.0 eq), sodium thiomethoxide (301 mg, 4.29 mmol, 1.0 eq) in DMF (10 mL) was stirred at 0 °C for 2 hours. The mixture was poured into H2O (50 mL) and extracted with EtOAc (3 x 20ml). The combined organic layers were washed with brine (50 mL), dried over ISfeSCL, filtered and concentrated. The crude was purified by flash chromatography (SiCh, 50% EtOAc in PE) to give 3-chloro-6- methyl-4-methylsulfanyl-pyridazine (515 mg, 2.95 mmol, 69% yield) as an off-white solid. LC- MS: m/z = 174.7 [M+H]+, ESI pos. 'H NMR (400 MHz, CDCI3) 8 = 6.97 (s, 1H), 2.67 (s, 3H), 2.49 (s, 3H).

Step 2: 3-chloro-6-methyl-4-methylsulfonyl-pyridazine

To a solution of 3-chloro-6-methyl-4-methylsulfanyl-pyridazine (450 mg, 2.58 mmol, 1.0 eq) in DCM (20 mL) was added mCPBA (1.31 g, 6.44 mmol, 2.5 eq) at 0 °C. The reaction mixture was stirred at 20 °C for 16 hours. The reaction mixture was poured into saturated aqueous NaHCOs (40mL) under stirring, and was extracted with DCM (3 x 30 mL). The combined organic layers were driede over Na2SO4, filtered and. The residue was purified by preparative TLC (PEZEtOAc 2: 1) to give 3-chloro-6-methyl-4-methylsulfonyl-pyridazine (100.0 mg, 0.48 mmol, 18.78% yield) as white solid. LC-MS: m/z = 206.9 [M+H]+, ESI pos.

Step 3: N-( 6-methyl-4-methylsulfonyl-pyridazin-3-yl)-lH-benzimidazol-5- amine

A mixture of 3-chloro-6-methyl-4-methylsulfonyl-pyridazine (70 mg, 0.34 mmol, 1.0 eq) and 5- aminobenzimidazole (45 mg, 0.34 mmol, 1.0 eq) in iPrOH (3 mL) was stirred at 120 °C for 12 hours. The reaction mixture was concentrated. The residue was purified by preparative TLC (DCM/MeOH 10: 1) to give N-(6-methyl-4-methylsulfonyl-pyridazin-3-yl)-lH-benzimidazol -5- amine (30 mg, 0.1 mmol, 29% yield) as a yellow solid. LC-MS: m/z = 304.1 [M+H]+, ESI pos.

Building block G.3: 5-(lH-benzimidazol-5-yl)-2-oxa-5-azaspiro[3.4]octane

Step 1: 5-(3,4-dinitrophenyl)-2-oxa-5-azaspiro[3.4]octane

To a solution of 4-fluoro-l,2-dinitro-benzene (100 mg, 0.537 mmol, 1.0 eq) and 2-oxa-5- azaspiro[3.4]octane (61 mg, 0.537 mmol, 1.0 eq) in NMP (2 mL) was added DIEA (141 pL, 0.806 mmol, 1.5 eq) . The reaction mixture was stirred for 1 hour at 70 °C. The reaction mixture was poured into water (30 mL) and extracted with EtOAc (3 x 30 mL). The combined organic layers were washed with brine (30 mL), dried over ISfeSCU, filtered and concentrated. The crude product was purified by flash chromatography (SiCh, 20-80% EtOAc in heptane) to give 5-(3,4- dinitrophenyl)-2-oxa-5-azaspiro[3.4]octane (124 mg, 0.435 mmol, 81% yield) as a yellow solid. LC-MS: m/z = 280.2 [M+H]+, ESI pos.

Step 2: [ 2-amino-4-(2-oxa-5-azaspiro[ 3.4 ] octan-5-yl)phenyl amine

A solution of 5-(3,4-dinitrophenyl)-2-oxa-5-azaspiro[3.4]octane (124 mg, 0.435 mmol, 1.0 eq) in MeOH (2.24 mL) and THF (2.24 mL) was degassed with argon. Pd/C (22 mg, 0.021 mmol, 0.05 eq) was added. The reaction mixture was degassed with EE and stirred with EE balloon for 4h at RT. The reaction mixture was filtered and the filtrate was concentrated to give [2-amino-4-(2- oxa-5-azaspiro[3.4]octan-5-yl)phenyl]amine (80 mg, 0.331 mmol, 76% yield) as a dark green liquid. LC-MS: m/z = 220.2 [M+H]+, ESI pos.

Step 3: 5-(lH-benzimidazol-5-yl)-2-oxa-5-azaspiro[3.4]octane

To a solution of [2-amino-4-(2-oxa-5-azaspiro[3.4]octan-5-yl)phenyl]amine (80 mg, 0.329 mmol, 1.0 eq) in EtOH (2.15 mL) was added trimethyl orthoformate (363 uL, 3.29 mmol, 10 eq) and p-toluenesulfonic acid monohydrate (6 mg, 0.033 mmol, 0.10 eq). The reaction mixture was stirred at 80 °C for 1 h.The reaction mixture was concentrated. The residue was suspended in sat. aq. NaHCCh (50 mL) and extracted with DCM (3 x 50 mL). The combined organic layers were washed with brine (50 mL), dried over ISfeSCL, filtered and concentrated. The crude was purified by flash chromatography (SiCE, 0-10% MeOH in DCM) to give 5-(lH-benzimidazol-5- yl)-2-oxa-5-azaspiro[3.4]octane (43 mg, 0.188 mmol, 57% yield) as a red solid. LC-MS: m/z = 230.2 [M+H]+, ESI pos.

Building block G.4: N-(lH-benzimidazol-5-yl)-4-methyl-2,3-dihydropyridazino[4,5- b] [1,4 / oxazin-8-amine

Step 1: 4-methyl-N-[ l-(2-trimethylsilylethoxymethyl)benzimidazol-5-yl]-2, 3- dihydropyridazino[ 4, 5-b ] [ 1, 4 ] oxazin-8-amine

To a solution of 8-chloro-4-methyl-2,3-dihydropyridazino[4,5-b][l,4]oxazine (66643-52-5) (1.0 g, 5.39 mmol, 1.0 eq) in 2-methyl-2-butanol (60.0 mL, 5.39 mmol, 1.0 eq) was added l-(2- trimethylsilylethoxymethyl)benzimidazol-5-amine (317830-35-6) (1.42 g, 5.39 mmol, 1.0 eq), KOtBu (1.55 g, 16.16 mmol, 3.0 eq) and RuPhos Pd G4 (229.08 mg, 0.27 mmol, 0.05 eq). The reaction mixture was bubbled with N2 for lOmin and stirred at 100 °C for 16 h. The reaction mixture was cooled to RT, poured into sat. aq. NH4CI (100 mL) and extracted with EtOAc (3 x 50 mL). The combined organic layers were washed with brine (50 mL), dried over Na2SO4, filtered and concentrated. The residue was purified by flash chromatography (SiO2, 0-20% MeOH in DCM) to give 4-methyl-N-[l-(2-trimethylsilylethoxymethyl)benzimidazol-5-y l]-2,3- dihydropyridazino[4,5-b][l,4]oxazin-8-amine (1.2 g, 2.91 mmol, 54% yield) as brown gum. LC- MS: m/z = 413.1 [M+H]+, ESI pos.

Step 2: N-(lH-benzimidazol-5-yl)-4-methyl-2, 3-dihydropyridazino[ 4, 5-b ] [ 1, 4 ] oxazin-8-amine

A solution of 4-methyl-N-[l-(2-trimethylsilylethoxymethyl)benzimidazol-5-y l]-2,3- dihydropyridazino[4,5-b][l,4]oxazin-8-amine (1.2 g, 2.91 mmol, 1.0 eq) in TFA (20 mL) was stirred at 50 °C for 1 h. The reaction mixture was concentrated, poured into sat. aq. NaHCO3 (50 mL) and extracted with EtOAc (3 x 50 mL). The combined organic layers were dried over Na2SO4, filtered and concentrated. The residue was purified by flash chromatography (SiCL, 0- 20% MeOH in EtOAc) to give N-(lH-benzimidazol-5-yl)-4-methyl-2,3-dihydropyridazino[4,5- b][l,4]oxazin-8-amine (700 mg, 2.48 mmol, 85% yield) as a yellow solid. LC-MS: m/z = 283.1 [M+H]+, ESI pos. 'H NMR (400 MHz, METHANOL-d4) 5 = 8.26 (s, 1H), 8.11 (d, J = 1.9 Hz, 1H), 8.07 (s, 1H), 7.52 (d, J = 8.8 Hz, 1H), 7.34 (dd, J= 1.9, 8.7 Hz, 1H), 4.48 - 4.43 (m, 2H), 3.48 - 3.42 (m, 2H), 3.03 (s, 3H).

Building block G.5: l-(lH-benzimidazol-5-yl)-N,N-dimethyl-pyrrolidine-2-carboxam ide Building block G.5 was prepared in analogy to Building block G.3 using N,N- dimethylpyrrolidine-2-carboxamide (433980-61-1) in step 1.

LC-MS: m/z = 259.2 [M+H]+, ESI pos.

Building block G.6: (4aS, 7aR)-6-(lH-benzimidazol-5-yl)-4-methyl-2,3,4a,5, 7, 7a- hexahydropyrrolo[ 3, 4-b ] [ 1, 4 ] oxazine

Building block G.6 was prepared in analogy to Building block G.3 using (4aS,7aR)-4-methyl- 3,4a,5,6,7,7a-hexahydro-2H-pyrrolo[3,4-b][l,4]oxazine (1360534-98-0) in step 1.

LC-MS: m/z = 259.3 [M+H]+, ESI pos.

Building block G. 7: N-(lH-benzimidazol-5-yl)cyclopropanecarboxamide

Step 1: N-[ l-(2-trimethylsilylethoxymethyl)benzimidazol-5-yl] cyclopropanecarboxamide

To a solution of cyclopropanecarboxylic acid (196 mg, 2.28 mmol, 1.2 eq) in DMF (5 mL) was added HATU (670 mg, 2.85 mmol, 1.5 eq) and the mixture was stirred at 25 °C for 30min. DIPEA (1.0 mL, 5.69 mmol, 3.0 eq) was added and the mixture was stirred at 25 °C for 30 min. The reaction mixture was diluted with water (50 mL) and extracted by EtOAc (3 x 20 mL). The combined organic layers were washed with brine (20 mL), dried over ISfeSCU, filtered and concentrated. The residue was purified by flash chromatography (SiCL, 50% EtOAc in PE) to give N-[l-(2-trimethylsilylethoxymethyl)benzimidazol-5-yl]cyclopr opanecarboxamide (550 mg, 1.66 mmol, 79% yield) as a brown solid. LC-MS: m/z = 332.0 [M+H]+, ESI pos.

Step 2: N-(lH-benzimidazol-5-yl)cyclopropanecarboxamide

To N-[l-(2-trimethylsilylethoxymethyl)benzimidazol-5-yl]cyclopr opanecarboxamide (500 mg, 1.51 mmol, 1.0 eq) was added TFA (1.0 mL) and the reaction mixture was stirred at 25 °C for 1 h. The reaction mixture was concentrated to give N-(lH-benzimidazol-5- yl)cyclopropanecarboxamide (268 mg, 1.33 mmol, 88% yield) as brown oil which was used without further purification. LC-MS: m/z = 202.1 [M+H]+, ESI pos.

Building block G.8: (3aS,6aS)-l-(lH-benzimidazol-5-yl)-2,3,3a,4,5,6a-hexahydropy rrolo[3,4- b]pyrrol-6-one

Building block G.8 was prepared in analogy to Building block G.3 using (3aS,6aS)-l-(3,4- diaminophenyl)-2,3,3a,4,5,6a-hexahydropyrrolo[2,3-c]pyrrol-6 -one (1523530-51-9) in step 1.

LC-MS: m/z = 243.1 [M+H]+, ESI pos.

Building block G.9: 4-(lH-benzimidazol-5-yl)-l-methyl-pyrimidin-2-one

Step 1: l-methyl-4-[l-(2-trimethylsilylethoxymethyl)benzimidazol-5-y l]pyrimidin-2-one

A mixture of trimethyl-[2-[[5-(4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2-y l)benzimidazol-l- yl]methoxy]ethyl]silane (780 mg, 2.08 mmol, 1.0 eq), 4-chloro-l-methyl-pyrimidin-2-one (361 mg, 2.5 mmol, 1.2 eq), ISfeCCL (442 mg, 4.17 mmol, 2.0 eq) and Pd(dppf) C12 (152 mg, 0.21 mmol, 0.1 eq) in 1,4-dioxane (2.5 mL) and water (0.5 mL) was stirred at 100 °C for 16 h under N2. The mixture was concentrated. The residue was purified by flash chromatography (SiCL, 0- 20% MeOH in EtOAc) to give 1 -methyl -4-[l -(2 -trimethyl silyl ethoxymethyl)benzimidazol-5- yl]pyrimidin-2-one (407 mg, 1.14 mmol, 49% yield) as a yellow oil. LC-MS: m/z = 357.3 [M+H]+, ESI pos.

Step 2: 4-(lH-benzimidazol-5-yl)-l-methyl-pyrimidin-2-one

A mixture of l-methyl-4-[l -(2 -trimethyl silyl ethoxymethyl)benzimidazol-5-yl]pyrimidin-2-one (450 mg, 1.26 mmol, 1.0 eq) in TFA (5.0 mL) was stirred at 50 °C for 1 h. The mixture was concentrated to give 4-(lH-benzimidazol-5-yl)-l-methyl-pyrimidin-2-one (400 mg, 1.18 mmol, 93% yield) as a yellow solid. LC-MS: m/z = 227.2 [M+H]+, ESI pos. 'H NMR (400 MHz, METHANOL-d4) 5 = 9.44 (s, 1H), 8.64 (s, 1H), 8.36 (dd, J = 1.1, 8.8 Hz, 1H), 8.30 (d, J= 6.8 Hz, 1H), 7.97 (d, J= 8.7 Hz, 1H), 7.23 (d, J= 6.8 Hz, 1H), 3.65 (s, 3H).

Building block G.10: 5-(6-methylpyridazin-3-yl)-lH-benzimidazole

Building block G.10 was prepared in analogy to Building block G.9 using 4-bromo-3-methoxy- 1-methyl-lH-pyrazole (1350323-85-1) in step 1.

LC-MS: m/z = 211.1 [M+H]+, ESI pos.

Building block G.ll: (2S)-l-(lH-benzimidazol-5-yl)pyrrolidine-2-carbonitrile

Building block G.ll was prepared in analogy to Building block G.3 using (2S)-2- Pyrrolidinecarbonitrile (CAS: 204387-53-1) in step 1.

LC-MS: m/z = 213.4 [M+H]+, ESI pos.

Building block G.12: 4-[ [6-(lH-benzimidazol-5-yloxy)pyridazin-3-yl] methyl] morpholine

Step 1: 4- [[6-(l-tritylbenzimidazol-5-yl)oxypyridazin-3-yl] methyl] morpholine

A mixture of l-tritylbenzimidazol-5-ol (100 mg, 0.27 mmol, 1.0 eq), 4-[(6-chloropyridazin-3- yl)methyl]morpholine (57 mg, 0.27 mmol, 1.0 eq), KHCO3 (53.11 mg, 0.53 mmol, 2.0 eq) and DMF (2 mL) was stirred at 130 °C for 12 hours. The reaction mixture was concentrated and the residue was purified by flash chromatography (SiCh, 0-20% MeOH in EtOAc) to give 4-[[6-(l - tritylbenzimidazol-5-yl)oxypyridazin-3-yl]methyl]morpholine (70 mg, 0.13 mmol, 48% yield) as yellow solid. LC-MS: m/z = 554.1 [M+H]+, ESI pos. Step 2: 4-[[ 6-(lH-benzimidazol-5-yloxy)pyridazin-3-yl] methyl] morpholine

4-[[6-(l-tritylbenzimidazol-5-yl)oxypyridazin-3-yl]methyl ]morpholine (70 mg, 0.13 mmol, 1.0 eq.) was dissolved in TFA (2 mL) and the mixture was stirred at 0 °C for 2 hours. The reaction mixture was concentrated to give 4-[[6-(lH-benzimidazol-5-yloxy)pyridazin-3- yl]methyl]morpholine (0.11 mmol, 85% yield) which was used without further purification. LC- MS: m/z = 312.3 [M+H]+, ESI pos.

Building block G.13: 5-(6-methylpyridazin-3-yl)oxy-lH-benzimidazole

Building block G.13 was prepared in analogy to Building block G.12 using 3-chloro-6- methylpyridazine (CAS: 1121-79-5) in step 1.

LC-MS: m/z = 227.2 [M+H]+, ESI pos. 'H NMR (400 MHz, DMSO-d6) 5 = 8.24 (s, 1H), 7.61 (dd, J= 4.8, 8.9 Hz, 2H), 7.39 (d, J= 2.1 Hz, 1H), 7.30 (d, J= 9.0 Hz, 1H), 7.01 (dd, J= 2.3, 8.6 Hz, 1H), 3.17 (s, 3H).

Building block G.14: 5-[ 6-[ ( 4-methylpiperazin-l-yl)methyl ]pyridazin-3-yl oxy-1 H- benzimidazole

Building block G.14 was prepared in analogy to Building block G.12 using 3-chloro-6-[(4- methyl-l-piperazinyl)methyl]pyridazine (CAS: 1566269-35-9) in step 1.

LC-MS: m/z = 325.2 [M+H]+, ESI pos.

Building block G.15: N-(lH-benzimidazol-5-yl)-2-(l-piperidyl)acetamide Building block G.15 was prepared in analogy to Building block G.7 using 1 -piperidineacetic acid (CAS: 3235-67-4) in step 1.

LC-MS: m/z = 259.1 [M+H]+, ESI pos.

Building block G.16: 2-(lH-benzimidazol-5-yl)-6-methyl-5H-pyrrolo [ 3, 4-b ]pyridin- 7 -one

Building block G.16 was prepared in analogy to Building block G.9 using 2-chloro-5,6-dihydro- 6-methyl-7H-pyrrolo[3,4-b]pyridin-7-one (CAS: 1201924-35-7) in step 1.

LC-MS: m/z = 265.2 [M+H]+, ESI pos.

Building block G.l 7: N-(lH-benzimidazol-5-yl)-l-fluoro-cyclopropanecarboxamide

Building block G.17 was prepared in analogy to Building block G.7 using 1- fluorocyclopropanecarboxylic acid (.CAS: 137081-41-5) in step 1.

LC-MS: m/z = 220.0 [M+H]+, ESI pos.

Building block G.18: 6-fluoro-N-(6-methylpyridazin-3-yl)-lH-benzimidazol-5-amine

Building block G.18 was prepared in Example 92, step 2.

Building block G.19: l-[5-(lH-benzimidazol-5-yl)oxazol-2-yl]pyrrolidin-2-one

Step 1: 4-bromo-N-oxazol-2-yl-butanamide To a solution of l,3-oxazol-2-amine (2.00 g, 23.79 mmol, 1.0 eq) and pyridine (5.77 mL, 71.36 mmol, 3.0 eq) in DCM (50 mL) was added 4-bromobutyryl chloride (6.61 g, 35.68 mmol, 1.5 eq) dropwise slowly at 0 °C. The reaction mixture was stirred at 0 °C for 1 hour. The reaction mixture was poured into H2O (200 mL) and extracted with DCM (3 x 100 mL). The combined organic layers were washed with 0.5N HC1 (200mL), then washed with brine (300 mL), dried over Na2SO4, filtered and concentrated to give 4-bromo-N-oxazol-2-yl-butanamide (2.60 g, 11.16 mmol, 47% yield) as yellow oil which was used without further purification. LC-MS: m/z = 233.0 [M+H]+, ESI pos.

Step 2: l-oxazol-2-ylpyrrolidin-2-one

To a solution of 4-bromo-N-oxazol-2-yl-butanamide (2.6 g, 11.16 mmol, 1.0 eq) in DMSO (50 mL) was added NaOAc (2.29 g, 27.89 mmol, 2.5 eq). The reaction mixture was stirred at 100 °C for 30 minutes. The reaction mixture was cooled to RT, concentrated and the residue was purified by flash chromatography (SiCh, 0-20% MeOH in EtOAc) to give l-oxazol-2- ylpyrrolidin-2-one (500 mg, 3.29 mmol, 29% yield) as a yellow solid. LC-MS: m/z = 153.0 [M+H]+, ESI pos. 'H NMR (400 MHz, METHANOL-d4) 5 = 7.70 (d, J= 0.9 Hz, 1H), 7.08 (d, J = 0.8 Hz, 1H), 4.00 (t, J= 7.1 Hz, 2H), 2.60 (t, J= 8.1 Hz, 2H), 2.21 (quin, J= 7.6 Hz, 2H)

Step 3: l-(5-bromooxazol-2-yl)pyrrolidin-2-one

To a solution of l-oxazol-2-ylpyrrolidin-2-one (500 mg, 3.29 mmol, 1.0 eq) in DMF (17 mL) was added NBS (585 mg, 3.29 mmol, 1.0 eq). The reaction mixture was stirred at 30 °C for 1 hour. The reaction mixture was concentrated and the residue was purified by flash chromatography (SiCL, 0-20% MeOH in EtOAc) to give l-(5-bromooxazol-2-yl)pyrrolidin-2-one (400 mg, 1.73 mmol, 53% yield) as a yellow solid. LC-MS: m/z = 230.9 [M+H]+, ESI pos. 'H NMR (400 MHz, METHANOL-d4) 5 = 7.03 (s, 1H), 3.97 (t, J= 7.1 Hz, 2H), 2.60 (t, J= 8.1 Hz, 2H), 2.26 - 2.17 (m, 2H).

Step 4: l-[5-[l-(2-trimethylsilylethoxymethyl)benzimidazol-5-yl]oxaz ol-2-yl]pyrrolidin-2-one

To a solution of l-(5-bromooxazol-2-yl)pyrrolidin-2-one (400 mg, 1.73 mmol, 1.0 eq) and trimethyl-[2-[[5-(4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2-y l)benzimidazol-l- yl]methoxy]ethyl]silane (972 mg, 2.6 mmol, 1.5 eq) in 1,4-dioxane (10 mL) was added Na2COs (459 mg, 4.33 mmol, 2.5 eq). The mixture was bubbled with N2 for 10 minutes. Pd(dppf)C12*DCM (283 mg, 0.35 mmol, 0.2 eq) and H2O (2 mL) were added the reaction mixture was stirred at 80 °C for 2 hours under N2. The reaction mixture was cooled to RT. The reaction mixture was diluted with H2O (40 mL) and extracted with EtOAc (2 x 30 mL). The combined organic layers were dried over Na2SO4, filtered, and concentrated. The residue was purified by flash chromatography (SiCh, 0-100% EtOAc) to give l-[5-[l-(2- trimethylsilylethoxymethyl)benzimidazol-5-yl]oxazol-2-yl]pyr rolidin-2-one (500 mg, 1.25 mmol, 72% yield) as yellow oil. LC-MS: m/z = 399.1 [M+H]+, ESI pos.

Step 5: l-[5-(lH-benzimidazol-5-yl)oxazol-2-yl]pyrrolidin-2-one l-[5-[l -(2 -trimethylsilyl ethoxymethyl)benzimidazol-5-yl]oxazol -2 -yl]pyrrolidin-2-one (500 mg, 1.25 mmol, 1.0 eq) was dissolved with TFA (5.0 mL). The solution was stirred at 20 °C for 1 hour. The reaction mixture was concentrated. The residue was dissolved in ACN (1 mL) and H2O (10 mL) and the mixture was lyophilized to afford l-[5-(lH-benzimidazol-5-yl)oxazol-2- yl]pyrrolidin-2-one (400 mg, 1.05 mmol, 83% yield) as yellow solid which was used without further purification. LC-MS: m/z = 269.0 [M+H]+, ESI pos.

Building block G.20: N-(6-methylpyridazin-3-yl)-6-(oxetan-3-ylmethyl)-lH-benzimid azol-5- amine

Step 1: tert-butyl N-(5-bromo-4-methyl-2-nitro-phenyl)-N-tert-butoxycarbonyl-ca rbamate

To a solution of 5-bromo-4-methyl-2-nitro-aniline (25.0 g, 108.2 mmol, 1.0 eq) in DMF (100 mL) was added slowly NaH (5.19 g, 129.84 mmol, 1.2 eq) and the mixture was stirred at 0°C for 10 min. A solution of di -t-butyl di carb onate (28.34 g, 129.84 mmol, 1.2 eq) in DMF (300 mL) was added dropwise and the mixture was stirred at RT for 14 hours. The reaction mixture was diluted with water (300 mL) and extracted with EtOAc (3 x 300 mL). The combined organic layers were dried over Na2SO4, filtered and concentrated. The residue was purified by flash chromatography (SiO2, 0-10% EtOAc in PE) and concentrated to give tert-butyl N-(5-bromo-4- methyl-2-nitro-phenyl)-N-tert-butoxycarbonyl-carbamate (26.0 g, 60.29 mmol, 50% yield)as orange solid. 'H NMR (400 MHz, CDCI3) 8 = 7.98 (s, 1H), 7.53 (s, 1H), 2.52 (s, 3H), 1.44 (s, 18H).

Step 2: tert-butyl N-[5-bromo-4-(bromomethyl)-2-nitro-phenyl]-N-tert-butoxycarb onyl- carbamate To a solution of tert-butyl N-(5-bromo-4-methyl-2-nitro-phenyl)-N-tert-butoxycarbonyl- carbamate (25.0 g, 57.97 mmol, 1.0 eq) in trifluoromethylbenzene (10 mL) were added N- bromosuccinimide (12.38 g, 69.56 mmol, 1.2 eq) and benzoyl peroxide (1.4 g, 5.8 mmol, 0.1 eq). The reaction mixture was stirred at 80 °C for 16 hours. The reaction mixture was cooled to RT and poured into water (50 mL). The mixture was extracted with DCM (2 x 100 mL). The combined organic layers were washed with brine (100 mL), dried over Na2SO4, filtered, and concentrated. The residue was purified by flash chromatography (SiCL, 25% EtOAc in PE) to give tert-butyl N-[5-bromo-4-(bromomethyl)-2-nitro-phenyl]-N-tert-butoxycarb onyl-carbamate (23.0 g, 45.08 mmol, 77.77% yield) as a yellow solid. 'H NMR (400 MHz, CDC1 ₃ ) 8 = 9.74 (br s, 1H), 8.98 (s, 1H), 8.32 (s, 1H), 4.60 (s, 2H), 1.58 (br s, 9H).

Step 3: tert-butyl N- 5-bromo-2-nitro-4-[ (triphenyl- 5-phosphanylidene)methyl] phenyl] -N-tert- butoxycarbonyl-carbamate

To a mixture of tert-butyl N-[5-bromo-4-(bromomethyl)-2-nitro-phenyl]-N-tert-butoxycarb onyl- carbamate (7.0 g, 13.72 mmol, 1.0 eq) in toluene (100 mL) was added triphenylphosphine (3.6 g, 13.72 mmol, 1.0 eq). The reaction was stirred at 110 °C for 12 hours. The reaction mixture was cooled to RT and concentrated. The residue was suspended in PE (50 mL), stirred at 30 °C for 1 h and filtered. The filtrate was concentrated to give tert-butyl N-[5-bromo-2-nitro-4-[(triphenyl- X5-phosphanylidene)methyl]phenyl]-N-tert-butoxycarbonyl-carb amate (5.0 g, 7.23 mmol, 53% yield) as a yellow solid. LC-MS: m/z = 593.3 [M+H]+, ESI pos.

Step 4: tert-butyl N-[5-bromo-2-nitro-4-(oxetan-3-ylidenemethyl)phenyl] carbamate

To a cooled (0 °C) solution of tert-butyl N-[5-bromo-2-nitro-4-[(triphenyl-X5- phosphanylidene)methyl]phenyl]-N-tert-butoxycarbonyl-carbama te (6.0 g, 8.68 mmol, 1.0 eq) in THF (200 mL) was added KOtBu (1.46 g, 13.01 mmol, 1.5 eq) followed by 3-oxetanone (1.25 g, 17.35 mmol, 2.0 eq) and the reaction was stirred at 0 °C for 2 hours. The reaction mixture was poured into water (50 mL) and extracted with EtOAc (3 x 50 mL). The combined organic layers were washed with brine (50 mL), dried over Na2SO4, filtered and concentrated. The residue was purified by flash chromatography (SiO2, 25% EtOAc in PE) to afford tert-butyl N-[5-bromo-2- nitro-4-(oxetan-3-ylidenemethyl)phenyl]carbamate (2.0 g, 5.19 mmol, 60% yield) as a yellow solid.

Step 5: tert-butyl N-[5-[(6-methylpyridazin-3-yl)amino]-2-nitro-4-(oxetan-3- ylidenemethyl)phenyl carbamate To a mixture of tert-butyl N-[5-bromo-2-nitro-4-(oxetan-3-ylidenemethyl)phenyl]carbamat e (2.00 g, 5.19 mmol, 1.0 eq) and 3-amino-6-methylpyridazine (1.13 g, 10.38 mmol, 2.0 eq) in 1,4-dioxane (50 mL) was added CS2CO3 (5.07 g, 15.58 mmol, 3.0 eq) and [tBuBrettPhos Pd(allyl)]OTf (811 mg, 1.04 mmol, 0.2 eq), and the reaction was stirred at 80 °C for 12 hours under N2. The reaction mixture was cooled to RT, poured into water (50 mL), and the mixture was extracted with EtOAc (3 x 50 mL). The combined organic layers were washed with brine (50 mL), dried over ISfeSCU, filtered and concentrated. The residue was purified by flash chromatography (SiCL, 0-100% EtOAc in PE) to give tert-butyl N-[5-[(6-methylpyridazin-3- yl)amino]-2-nitro-4-(oxetan-3-ylidenemethyl)phenyl]carbamate (2.10 g, 5.08 mmol, 97% yield) as a brown solid. LC-MS: m/z = 414.2 [M+H]+, ESI pos.

Step 6: tert-butyl N-[2-amino-5-[(6-methylpyridazin-3-yl)amino]-4-(oxetan-3- ylmethyl)phenyl] carbamate

To a mixture of tert-butyl N-[5-[(6-methylpyridazin-3-yl)amino]-2-nitro-4-(oxetan-3- ylidenemethyl)phenyl]carbamate (200 mg, 0.48 mmol, 1.0 eq) in MeOH (10 mL) was added Pd/C (51 mg, 0.05 mmol, 0.1 eq) and the reaction was stirred at 30 °C for 3 hours under H2 balloon. The reaction mixture was filtrated and the filtrate was concentrated to give tert-butyl N- [2-amino-5-[(6-methylpyridazin-3-yl)amino]-4-(oxetan-3-ylmet hyl)phenyl]carbamate (150 mg, 0.39 mmol, 80% yield) as an off white oil which was used without further purification. LC-MS: m/z = 386.2 [M+H]+, ESI pos.

Step 7: N4-(6-methylpyridazin-3-yl)-5-(oxetan-3-ylmethyl)benzene-l,2 , 4-triamine

To a solution of tert-butyl N-[2-amino-5-[(6-methylpyridazin-3-yl)amino]-4-(oxetan-3- ylmethyl)phenyl]carbamate (150 mg, 0.39 mmol, 1.0 eq) in DCM (2 mL) was added TFA (1.0 mL) and the reaction was stirred at 30 °C for 2 hours. The reaction mixture was concentrated to give N4-(6-methylpyridazin-3-yl)-5-(oxetan-3-ylmethyl)benzene-l, 2, 4-triamine (110 mg, 0.39 mmol, 99% yield) as a yellow oil which was used without further purification. LC-MS: m/z = 286.1 [M+H]+, ESI pos.

Step 8: N-( 6-methylpyridazin-3-yl)-6-(oxetan-3-ylmethyl)-lH-benzimidazo l-5-amine

To a solution of N4-(6-methylpyridazin-3-yl)-5-(oxetan-3-ylmethyl)benzene-l, 2, 4-triamine (150 mg, 0.53 mmol, 1.0 eq) in MeOH (2 mL) were added trimethyl orthoformate (574 pL, 5.26 mmol, 10 eq) and TsOH (9 mg, 0.05 mmol, 0.1 eq). The solution was stirred at 80 °C for 2 hours. The reaction mixture was poured into water (50 mL) and extracted with EtOAc (3 x 50 mL). The combined organic layers were washed with brine (50 mL), dried over ISfeSCU, filtered and concentrated. The residue was purified by preparative TLC (DCM : MeOH 10: 1) to afford N-(6-methylpyridazin-3-yl)-6-(oxetan-3-ylmethyl)-lH-benzimid azol-5-amine (100 mg, 0.34 mmol, 64% yield) as a yellow oil. LC-MS: m/z = 296.2 [M+H]+, ESI pos.

Building block G.21: 5-(3-methoxy-l-methyl-pyrazol-4-yl)-l~{H}-benzimidazole

Building block G.21 was prepared in analogy to Building block G.9 using 2-chloro-5,6-dihydro- 6-methyl-7H-pyrrolo[3,4-b]pyridin-7-one (CAS: 1201924-35-7) in step 1.

LC-MS: m/z = 265.2 [M+H]+, ESI pos.

Building block Hl: l-(3-acetyl-6-chloro-2-pyridyl)-5-methyl-6, 7-dihydro-4~{H}-pyrazolo[4,3- c ]pyridine-3-carbonitrile

To a stirred solution of 4,5,6,7-Tetrahydro-5-methyl-lH-pyrazolo[4,3-c]pyridine-3-car bonitrile (1522689-76-4) (89 mg, 0.544 mmol, 1.0 eq) and l-(6-chloro-2-fluoro-3-pyridyl)ethanone (94 mg, 0.544 mmol, 1.0 eq) at RT in DMSO (3 mL) under an argon atmosphere was added DIPEA (190 uL, 1.09 mmol, 2.0 eq). The reaction mixture was stirred at RT for 5 hours. The reaction mixture was poured into H2O (50 mL) and extracted with EtOAc (3 x 40 ml). The combined organic layers were washed with brine (30 ml), dried over ISfeSCU, filtered and concentrated. The residue was purified by flash chromatography (SiCL, 0-50% EtOAc in heptane) to give l-(3- acetyl-6-chloro-2-pyridyl)-5-methyl-6,7-dihydro-4~{H}-pyrazo lo[4,3-c]pyridine-3-carbonitrile (63 mg, 0.386 mmol, 71% yield) as a white foam. LC-MS: m/z = 163.2 [M+H]+, ESI pos.

Building block H.2: l-(3-acetyl-6-chloro-2-pyridyl)-5-methyl-pyrazole-3-carbonit rile

Building block H.2 is prepared in Example 64, step 1.

Building block H.3: methyl 6-chloro-2-[3-(difluoromethyl)-5-methyl-pyrazol-l-yl]pyridin e-3- carboxylate

To a solution of 6-chloro-2-fluoro-nicotinic acid methyl ester (500 mg, 2.64 mmol, 1.0 eq) in DMF (4.21 mL) was added 3-(difluoromethyl)-5-methyl-lH-pyrazole (418 mg, 3.17 mmol, 1.2 eq) and K2CO3 (547 mg, 3.96 mmol, 1.5 eq). The reaction mixture was stirred at RT for 5 hours. The reaction was diluted with H2O (50 mL) and extracted with EtOAc (3 x 30 mL). The combined organic layers were washed with brine (30 mL), dried over ISfeSCU, filtered and concentrated. The residue was purified by flash chromatography (SiCh, 0-50% EtOAc in heptane) to give methyl 6-chloro-2-[3-(difluoromethyl)-5-methyl-pyrazol-l-yl]pyridin e-3- carboxylate (315 mg, 1.04 mmol, 40% yield) as a colorless oil. LC-MS: m/z = 302.1 [M+H]+, ESI pos. 'HNMR (600 MHz, CDCI3) 8 ppm 8.12 (d, J = 8.1 Hz, 1 H), 7.45 (d, J = 8.1 Hz, 1 H), 6.53 - 6.72 (m, 1 H), 6.42 - 6.45 (m, 1 H), 3.73 (s, 3 H), 2.55 (d, J= 0.8 Hz, 3 H).

Building block H.4: l-[6-chloro-2-[3-methyl-l-(2,2,2-trifluoroethyl)pyrazol-4-yl ]-3- pyridyl ethanone A mixture of 3-methyl-4-(4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2-yl)-l-( 2,2,2- trifluoroethyl)pyrazole (Building block A.10) (3.71 g, 12.79 mmol, 1.0 eq), l-(2-bromo-6- chl oro-3 -pyridyl)ethanone (3.0 g, 12.79 mmol, 1.0 eq), K2CO3 (3.54 g, 25.59 mmol, 2.0 eq) and Pd(dppf)C12'CH2C12 (1.04 g, 1.28 mmol, 0.1 eq) in 1,4-dioxane (60 mL) and water (6 mL) was stirred at 80 °C under N2 atmosphere for 12 h. The mixture was coold to RT and concentrated. The residue was purified by flash chromatography (SiCh, 0-25% EtOAc in heptane) to give 1- [6-chloro-2-[3-methyl-l-(2,2,2-trifluoroethyl)pyrazol-4-yl]- 3-pyridyl]ethanone (3.2 g, 10.07 mmol, 79% yield) as a yellow oil. LC-MS: m/z = 318.1 [M+H]+, ESI pos.

Building block H.5: l-[ 6-chloro-2-[ 3-(difluoromethyl)-5-ethyl-pyrazol-l-yl ]-3-pyridyl ] ethanone

To a solution of 3-(difluoromethyl)-5-ethyl-lH-pyrazole (1015779-27-7) (192 mg, 1.31 mmol, 1.2 eq) in DMF (3 mL) was added l-(6-chloro-2-fluoro-3-pyridyl)ethanone (150 mg, 0.864 mmol, 1.0 eq) and CS2CO3 (563 mg, 1.73 mmol, 2.0 eq). The reaction mixture was stirred at RT for 16 hours. The reaction mixture was diluted with H2O (30 mL) and extracted with DCM (3 x 30 mL). The combined organic layers were washed with brine (30 mL), dried over ISfeSCU, filtered and concentrated. The residue was purified by flash chromatography (SiCL, 0-100% EtOAc in heptane) to give l-[6-chloro-2-[3-(difluoromethyl)-5-ethyl-pyrazol-l-yl]-3- pyridyl] ethanone (118 mg, 0.34 mmol, 25.54%) as light brown solid. LC-MS: m/z = 300.0 [M+H]+, ESI pos. 'HNMR (600 MHz, DMSO-d6) 5 ppm 8.21 (d, J= 8.1 Hz, 1 H), 7.81 (d, J= 8.1 Hz, 1 H), 7.01 (t, J = 54.3 Hz, 1 H), 6.71 (s, 1 H), 2.92 (dd, J = 7.6, 0.7 Hz, 2 H), 2.01 (s, 3 H), 1.19 - 1.25 (m, 4 H).

Building block H.6: 1- [2- [3,5-bis(difhioromethyl)pyr azol- l-yl]-6-chloro-3-pyr idyl] ethanone l-(6-chloro-2-fluoro-3-pyridyl)ethanone (10 g, 57.61 mmol, 1.0 eq) was dissolved in DMF (200 mL) under Ar. CS2CO3 (37.54 g, 115.23 mmol, 2.000 eq) was added and the mixture was cooled to -60 °C. A solution of 3,5-bis(difluoromethyl)-lH-pyrazole (10.17 g, 60.49 mmol, 1.05 eq) in DMF (50 mL) was added dropwise. The reaction mixture was slowly warmed to 0 °C while stirring over 4 hours. The reaction mixture was poured into H2O (1000 mL) water and extracted with EtOAc (3 x 250 mL). The combined organic layers were washed with water (200 mL), brine (200 mL), dried over Na2SO4, filtered and concentrated. The residue was purified by flash chromatography (SiCh, 0-60% EtOAc in heptane) to give l-[2-[3,5-bis(difluoromethyl)pyrazol- l-yl]-6-chloro-3-pyridyl]ethanone (14.7 g, 45.51 mmol, 79% yield) as a light yellow oil. LC-MS: m/z = 322.0 [M+H]+, ESI pos. 'H NMR (600 MHz, CDCI3) 8 ppm 7.90 (d, J = 8.1 Hz, 1 H), 7.54 (br t, J= 55.0 Hz, 1 H), 7.45 (d, J= 8.1 Hz, 1 H), 7.04 (s, 1 H), 6.68 (t, J = 54.4 Hz, 1 H), 2.77 - 3.34 (m, 1 H), 2.17 (s, 3 H).

Building block H.7: l-[6-chloro-2-[3-(difluoromethyl)-5-methoxy-pyrazol-l-yl]-3- pyridyl ethanone

Step 1: 6-chloro-2-fluoro-3-(2-methyl-l, 3-dioxolan-2-yl)pyridine

To a solution of l-(6-chloro-2-fluoro-3-pyridyl)ethanone (5.0 g, 28.81 mmol, 1.0 eq) in toluene (100 mL) was added ethylene glycol (4.82 mL, 86.42 mmol, 3.0 eq) and TosOH (496 mg, 2.88 mmol, 0.1 eq) . The reaction was stirred at reflux overnight with azeotropic removal of H2O via Dean Stark trap. The reaction mixture was cooled to RT and concentrated to dryness. The residue was taken up in EtOAc (100 ml) and the solution was washed with H2O (2 x 50 ml) and brine (50 ml). The organic layer was dried over Na2SO4, filtered and concentrated. The residue was purified by flash chromatography (SiO2, 10% EtOAc in PE) to give 6-chloro-2-fluoro-3-(2- methyl-l,3-dioxolan-2-yl)pyridine (5.5 g, 25.27 mmol, 88% yield) as a whtie solid. LC-MS: m/z = 218.0 [M+H]+, ESI pos. 'H NMR (400 MHz, METHANOL-d4) 5 = 8.02 (dd, J= 7.9, 9.6 Hz, 1H), 7.46 - 7.25 (m, 1H), 4.12 - 4.06 (m, 2H), 3.87 - 3.78 (m, 2H), 1.69 (d, J= 0.7 Hz, 3H).

Step 2: [ 6-chloro-3-(2-methyl-l, 3-dioxolan-2-yl)-2-pyridyl hydrazine A mixture of 6-chloro-2-fluoro-3-(2-methyl-l,3-dioxolan-2-yl)pyridine (5.0 g, 22.98 mmol, 1.0 eq) and hydrazine hydrate (50.0 mL) was stirred at 50 °C for 2 h The reaction mixture cooled to RT, pourred into water (50 mL) and extracted with EtOAc (3 x 50 mL). The combined organic layers were washed with brine (50 mL), dried over anhydrous ISfeSCU, filtered and concentrated. The residue was purified by preparative TLC (PE:EtOAc 1 : 1) to give [6-chloro-3-(2-methyl-l,3- dioxolan-2-yl)-2-pyridyl]hydrazine (5.0 g, 21.77 mmol, 95% yield) as a white solid. LC-MS: m/z = 230.0 [M+H]+, ESI pos.

Step 3: 2-[ 6-chloro-3-(2-methyl-l , 3-dioxolan-2-yl)-2-pyridyl ]-3-(difluoromethyl)-lH-pyrazol-5- one

A mixture of [6-chloro-3-(2-methyl-l,3-dioxolan-2-yl)-2-pyridyl]hydrazine (500 mg, 2.18 mmol, 1.0 eq) and ethyl 4,4-difluoro-3-oxobutanoate (362 mg, 2.18 mmol, 1.0 eq) in toluene (10 mL) was stirred at 130 °C for 12 hours. The reaction mixture cooled to RT, poured into H2O (100 mL) and extracted with EtOAc (3 x 100 mL). The combined organic layers were washed with brine (50 mL), dried over Na2SO4, filtered and concentrated. The residue was purified by preparative HPLC (Phenomenex luna C18 150 x 40mm x 15pm, water with FA-ACN) to give 2- [6-chloro-3-(2-methyl-l,3-dioxolan-2-yl)-2-pyridyl]-3-(diflu oromethyl)-lH-pyrazol-5-one (90 mg, 0.27 mmol, 12% yield) as a white solid. LC-MS: m/z = 331.8 [M+H]+, ESI pos. ^J H NMR (400 MHz, DMSO-d6) 5 = 12.15 - 11.52 (m, 1H), 8.24 - 8.11 (d, 1H), 7.85 - 7.69 (d, 1H), 7.02 - 6.60 (t, 1H), 5.35 (s, 1H), 3.93 - 3.80 (m, 2H), 3.54 (br s, 2H), 1.70 - 1.53 (s, 3H).

Step 4: 6-chloro-2-[ 3-(difluoromethyl)-5-methoxy-pyrazol-l-yl ]-3-(2-methyl-l, 3-dioxolan-2- yl)pyridine

To a mixture of 2-[6-chloro-3-(2-methyl-l,3-dioxolan-2-yl)-2-pyridyl]-5-(dif luoromethyl)-lH- pyrazol-3-one (70 mg, 0.21 mmol, 1.0 eq) in DMF (1 mL) was added iodomethane (30 mg, 0.21 mmol, 1.0 eq). The reaction mixture was stirred at 30 °C for 1 hour. The reaction mixture was cooled to RT, poured into water (50 mL) and extracted with EtOAc (3 x 50 mL). The combined organic layers were washed with brine (50 mL3), dried over Na2SO4, filtered and concentrated. The residue was purified by preparative TLC (PE:EtOAc 2:1) to give 6-chloro-2-[3- (difluoromethyl)-5-methoxy-pyrazol-l-yl]-3-(2-methyl-l,3-dio xolan-2-yl)pyridine (20 mg, 0.06 mmol, 27% yield) as a white solid. LC-MS: m/z = 346.6 [M+H]+, ESI pos. 'H NMR (400 MHz, METHANOL-d4) 5 = 8.13 - 8.02 (m, 1H), 7.62 - 7.50 (m, 1H), 6.72 - 6.34 (m, 1H), 5.97 - 5.86 (m, 1H), 3.86 - 3.83 (m, 3H), 3.82 - 3.75 (m, 2H), 3.59 - 3.51 (m, 2H), 1.56 - 1.46 (m, 3H).

Step 5: l-[ 6-chloro-2-[ 3-(difluoromethyl)-5-methoxy-pyrazol-l-yl ]-3-pyridyl ] ethanone To a solution of 6-chloro-2-[3-(difluoromethyl)-5-methoxy-pyrazol-l-yl]-3-(2- methyl-l,3- dioxolan-2-yl)pyridine (80 mg, 0.23 mmol, 1.0 eq) in THF (1 mL) was added 1 N HC1 (1.0 mL) and the reaction was stirred at 70 °C for 12 hours. The reaction mixture was cooled to RT, poured into water (50 mL) and extracted with EtOAc (3 x 50 mL). The combined organic layers were washed with (50 mL), dried over Na2SO4, filtered and concentrated to give l-[6-chloro-2- [3-(difluoromethyl)-5-methoxy-pyrazol-l-yl]-3-pyridyl]ethano ne (60 mg, 0.2 mmol, 86% yield) as a yellow oil which was used without further purification. LC-MS: m/z = 301.9 [M+H]+, ESI pos.

Building block H.8: l-[6-chloro-2-[2-methyl-5-(2,2,2-trifluoroethyl)-l,2,4-triaz ol-3-yl]-3- pyridyl ethanone

Step 1 : N- (Z)-[ amino-(3-bromo-2-pyridyl)methylene ] amino ]-3, 3, 3 -trifluor o-propanamide

To a solution of 3,3,3-trifhioropropionic acid (4.5 g, 35.15 mmol, 1.2 eq) in DMF (20 mL) were added N'-amino-3-bromo-pyridine-2-carboxamidine (814263-27-9) (6.3 g, 29.3 mmol, 1.0 eq) followed by HATU (10.34 g, 43.94 mmol, 1.5 eq) and DIPEA (10.21 mL, 58.59 mmol, 2.0 eq) and the reaction mixture was stirred at 30 °C for 1 hour. The reaction mixture was poured into water (100 mL) and extracted with EtOAc (3 x 80 mL). The combined organic layers were washed with brine (60 mL), dried over Na2SO4, filtered and concentrated. The residue was purified by flash chromatography (SiO2, 100% EtOAc) to give N-[(Z)-[amino-(3-bromo-2- pyridyl)methylene]amino]-3,3,3-trifluoro-propanamide (4.0 g, 12.3 mmol, 42% yield) a light yellow solid. LC-MS: m/z = 324.9 [M+H]+, ESI pos.

Step 2: 3-bromo-2-[ 3-(2, 2, 2-trijluoroethyl)-lH-l , 2, 4-triazol-5-yl pyridine

A solution of N-[(Z)-[amino-(3-bromo-2-pyridyl)methylene]amino]-3,3,3-trif luoro-propanamide (3.9 g, 12.0 mmol, 1.0 eq) in ethylene glycol (7.45 g, 119.97 mmol, 10.0 eq) was stirred at 180 °C for 1 hour. The reaction mixture was cooled to RT and poured into water (50 mL). The mixture was extracted with EtOAc (3 x 50 mL). The combined organic layers were washed with brine (50 mL), dried over Na2SO4, filtered and concentrated. The residue was purified by flash chromatography (SiCh, 0-25% EtOAc in PE) to give 3-bromo-2-[3-(2,2,2-trifluoroethyl)-lH- l,2,4-triazol-5-yl]pyridine (2.0 g, 6.51 mmol, 54% yield) as a light brown solid. LC-MS: m/z = 306.9 [M+H]+, ESI pos. 'H NMR (400 MHz, METHANOL-d4) 5 = 8.69 (dd, J = 1.4, 4.6 Hz, 1H), 8.25 (dd, J= 1.4, 8.2 Hz, 1H), 7.46 (dd, J= 4.6, 8.1 Hz, 1H), 3.83 (q, J= 10.4 Hz, 2H).

Step 3: 3-bromo-2-[ 2-methyl-5-(2, 2, 2-trifluoroethyl)-l, 2, 4-triazol-3-yl pyridine

To a solution of 3-bromo-2-[3-(2,2,2-trifluoroethyl)-lH-l,2,4-triazol-5-yl]py ridine (2.0 g, 6.51 mmol, 1.0 eq) in DMF (20 mL) were added K2CO3 (1.36 g, 9.77 mmol, 1.5 eq) followed by iodomethane (1.39 g, 9.77 mmol, 1.5 eq). The reaction mixture was at 30 °C for 2 hours. The reaction mixture was poured into water (40 mL) and extracted with EtOAc (2 x 50 mL). The combined organic layers were washed with brine (30 mL), dried over Na2SO4, filtered and concentrated. The residue was purified by flash chromatography (SiO2, 0-25% EtOAc in PE) to give 3-bromo-2-[2-methyl-5-(2,2,2-trifluoroethyl)-l,2,4-triazol-3 -yl]pyridine (500 mg, 1.56 mmol, 60% yield) as a light brown. LC-MS: m/z = 320.9 [M+H]+, ESI pos.

Step 4: 3-( 1 -ethoxyvinyl) -2 -[ 2-methyl-5-(2, 2, 2-trifluoroethyl)-l, 2, 4-triazol-3-yl pyridine

To a solution of 3-bromo-2-[2-methyl-5-(2,2,2-trifluoroethyl)-l,2,4-triazol-3 -yl]pyridine (500 mg, 1.56 mmol, 1.0 eq) in toluene (20 mL) were added tributyl(l-ethoxyvinyl)tin (844 mg, 2.34 mmol, 1.5 eq) and bis(triphenylphosphine)palladium(II) chloride (82 mg, 0.12 mmol, 0.08 eq). The reaction mixture was bubbled with N2 for 10 minutes and stirred at 110 °C for 16 hours under N2. The mixture reaction was cooled to RT and quenched with saturated aqueous KF (50 ml) and stirred at room temperature for 16 hours. The mixture was extracted with EtOAc (3 x 50 mL). The combined organic layers were washed with brine (30 mL), dried over Na2SO4, filtered and concentrated to give 3-(l-ethoxyvinyl)-2-[2-methyl-5-(2,2,2-trifluoroethyl)-l,2,4 -triazol-3- yl]pyridine (450 mg, 1.44 mmol, 93% yield) as light brown oil which was used without further purification. LC-MS: m/z = 313.0 [M+H]+, ESI pos.

Step 5: l-[ 2-[ 2-methyl-5-(2, 2, 2-trifhioroethyl)-l, 2, 4-triazol-3-yl ]-3-pyridyl ethanone

To a solution of 3-(l-ethoxyvinyl)-2-[2-methyl-5-(2,2,2-trifluoroethyl)-l,2,4 -triazol-3- yl]pyridine (450 mg, 1.44 mmol, 1.0 eq) in THF (5 mL) was added aq. 1 N HC1 (5 mL) and the mixture was stirred at RT for 2 hours. The reaction mixture was poured into saturated aqueous NaHCCL (10 mL). The mixture was extracted with EtOAc (2 x 20 mL). The combined organic layers were washed with brine (10 mL), dried over Na2SO4, filtered and concentrated. The residue was purified by flash chromatography (SiO2, 0-25% EtOAc in PE) to give l-[2-[2- methyl-5-(2,2,2-trifluoroethyl)-l,2,4-triazol-3-yl]-3-pyridy l]ethanone (400 mg, 1.41 mmol, 98% yield) as light brown solid. LC-MS: m/z = 284.9 [M+H]+, ESI pos. 'H NMR (400 MHz, CDC1 ₃ ) 5 = 8.75 (dd, J= 1.6, 4.8 Hz, 1H), 7.85 (dd, J= 1.7, 7.9 Hz, 1H), 7.46 (dd, J= 4.9, 7.8 Hz, 1H), 4.21 (s, 3H), 3.57 (q, J = 10.3 Hz, 2H), 2.45 (s, 3H).

Step 6: l-[ 2-[ 2-methyl-5-(2, 2, 2-trifluoroethyl)-l, 2, 4-triazol-3-yl ]-l-oxido-pyridin-l-ium-3- yl] ethanone

To a solution of l-[2-[2-methyl-5-(2,2,2-trifluoroethyl)-l,2,4-triazol-3-yl]- 3-pyridyl]ethanone (450 mg, 1.58 mmol, 1.0 eq) in aq. H2O2 (10.0 mL) was added acetic acid (5 mL). The reaction mixture was stirred at 85 °C for 4 hours. The reaction mixture was cooled to RT, diluted with saturated Na2SOs (30 mL) and stirred for 1 hour. The resulting mixture was extracted with DCM (3 x 50 mL) and the combined organic layers were dried over Na2SO4, filtered and concentrated. The residue was purified by flash chromatography (SiCL, 0-10% MeOH in DCM) to give l-[2- [2-methyl-5-(2,2,2-trifluoroethyl)-l,2,4-triazol-3-yl]-l-oxi do-pyridin-l-ium-3-yl]ethanone (260 mg, 0.87 mmol, 55% yield) as an off white solid. LC-MS: m/z = 301.0 [M+H]+, ESI pos.

Step 7: l-[ 6-chloro-2-[ 2-methyl-5-(2, 2, 2-trifluoroethyl)-l, 2, 4-triazol-3-yl ]-3-pyridyl ethanone

A solution of l-[2-[2-methyl-5-(2,2,2-trifluoroethyl)-l,2,4-triazol-3-yl]- l-oxido-pyridin-l-ium- 3-yl]ethanone (260 mg, 0.87 mmol, 1.0 eq) in POCI3 (6.0 mL) was stirred at 80 °C for 2 hours. The reaction mixture was cooled to RT and concentrated. The concentrated residue was slowly quenched by dropwise addition to sat. aq. NaHCCL (30 mL) at RT with vigorous stirring. The mixture was extracted with EtOAc (3 x 50 mL) and the combined organic layers were dried over Na2SO4, filtered and concentracted. The residue was purified by flash chromatography (SiCh, 0- 40% EtOAc in PE) to give l-[6-chloro-2-[2-methyl-5-(2,2,2-trifluoroethyl)-l,2,4-triaz ol-3-yl]-3- pyridyl] ethanone (150 mg, 0.47 mmol, 54% yield) as an off white solid. LC-MS: m/z = 318.9 [M+H]+, ESI pos.

Building block H.9: l-[6-chloro-2-[3-(difluoromethoxy)-5-(difluoromethyl)pyrazol -l-yl]-3- pyridyl ethanone Step 1: 3-(difluoromethyl)-5-hydroxy-pyrazole-l -carboxylic acid tert-butyl ester

Di-tert-butyl dicarbonate (1.22 g, 1.3 mL, 5.58 mmol, 1.2 eq) was added to a suspension of 3- (difluoromethyl)-lH-pyrazol-5-ol (2416700-52-0) (800 mg, 5.97 mmol, 1.0 eq) in THF (15 mL). A solution of NaHCCL (1.17 g, 13.95 mmol, 3.0 eq) in H2O (15 mL) and 4- dimethylaminopyridine (9.11 mg, 74.58 umol, 0.10 eq) were added and the reaction mixture stirred at RT for 16 hours. The reaction was poured into sat. aq. NH4CI and the mixture was extracted with EtOAc/DCM 1 : 1 (3 x 50 mL). The combined organic layers were washed with brine (50 mL), dried over Na2SO4, filtered and concentrated to give 3-(difluoromethyl)-5- hydroxy-pyrazole-1 -carboxylic acid tert-butyl ester (1.4 g, 4.48 mmol, 75% yield) which was used without further purification. LC-MS: m/z = 135.0 [M+H-Boc]+, ESI pos.

Step 2: 5-(difhioromethoxy)-3-(difhioromethyl)pyrazole-l-carboxylic acid tert-butyl ester

To a mixture of 3-(difluoromethyl)-5-hydroxy-pyrazole-l-carboxylic acid tert-butyl ester (283 mg, 1.21 mmol, 1.0 eq) in DMF (12 mL) were added CS2CO3 (1.18 g, 3.63 mmol, 3.0 eq) and sodium chlorodifluoroacetate (276 mg, 1.81 mmol, 1.5 eq). The mixture was stirred at 80 °C for 2 hours. The reaction mixture was cooled to RT, poured into H2O (50 mL) and extracted with EtOAc (3 x 50 mL). The combined organic layers was washed with H2O (2 x 20 mL), brine (50 mL), dried over Na2SO4, filtered and concentrated to give 5-(difluoromethoxy)-3- (difhioromethyl)pyrazole-l -carboxylic acid tert-butyl ester (1.7 g, quant, yield) as a light brown solid which was used without further purification.

Step 3: 5-(difluoromethoxy)-3-(difluoromethyl)-lH-pyrazole

5-(difluoromethoxy)-3-(difluoromethyl)pyrazole-l-carboxyl ic acid tert-butyl ester (1.7 g, 5.98 mmol, 1.0 eq) was dissolved in DCM (15 mL) and TFA (2.3 mL, 29.91 mmol, 5.0 eq) was added. The reaction mixture was stirred at RT for 16 hours. The solvent reaction mixture was concentrated to give 5-(difluoromethoxy)-3-(difluoromethyl)-lH-pyrazole (1.1 g, quant, yield) which was used without further purification.

Step 4: l-[ 6-chloro-2-[ 3-(difluoromethoxy)-5-(difluoromethyl)pyrazol-l-yl ]-3-pyridyl ethanone

5-(difhioromethoxy)-3-(difhioromethyl)-lEl-pyrazole (1.1 g, 5.96 mmol, 1.15 eq) was dissolved in DMF (17.28 mL) under argon. l-(6-chloro-2-fluoro-3-pyridyl)ethanone (0.90 g, 5.19 mmol, 1.0 eq) and CS2CO3 (8.45 g, 25.93 mmol, 5.0 eq) were added and the reaction mixture was stirred at RT for 1 hour. The reaction mixture was poured into H2O (100 mL) and the mixture was extracted with EtOAc (3 x 50 mL). The combined organic layers were washed with water (2 x 30 mL), brine (100 mL), dried over Na2SO4, filtered and concentrated. The residue was purified by flash chromatography (SiCh, 10-100% EtOAc in heptane) to give l-[6-chloro-2-[3- (difluoromethoxy)-5-(difluoromethyl)pyrazol-l-yl]-3-pyridyl] ethanone (220 mg, 0.60 mmol, 10% yield) as a white solid. LC-MS: m/z = 338.1 [M+H]+, ESI pos. Building block H.10: l-[6-chloro-2-[3-(difluoromethoxy)-5-methyl-pyrazol-l-yl]-3- pyridyl ethanone

Building block H.10 was prepared as building block D.4.

Building block H.ll: l-[6-chloro-2-[3-(difluoromethyl)-5-methyl-pyrazol-l-yl]-3- pyridyl] ethanone

Building block H.ll was prepared as building block D.3.

Building block H.12: l-[6-chloro-2-[3-(difluoromethyl)-4,5-dimethyl-pyrazol-l-yl] -3- pyridyl ethanone

Step 3: 3-formyl-4, 5-dimethyl-pyr azole- 1 -carboxylic acid tert-butyl ester

Di-tert-butyl dicarbonate (259 mg, 1.19 mmol, 1.1 eq) was added to a suspension of 4,5- dimethyl-lH-pyrazole-3-carbaldehyde (112466-01-0) (529 mg, 4.26 mmol, 1.0 eq) in THF (10.58 mL) at 0 °C. A solution of NaHCCh (1.07 g, 12.78 mmol, 3.000 eq) in H2O (10 mL) was added and the reaction mixture was stirred at 0 °C for 1 hour. Then the ice bath was removed and the reaction allowed to stir at RT for 16 hours. The reaction mixture was diluted with H2O (60 mL) and extracted with DCM (3 x 50 mL). The combined organic layers were dried over Na2SO4, filtered and concentrated. The residue was purified by flash chromatography (SiCh, 10- 50% EtOAc in heptane) to give 3-formyl-4,5-dimethyl-pyrazole-l-carboxylic acid tert-butyl ester (956 mg, 4.26 mmol, 100% yield) as a colorless oil. LC-MS: m/z = 125.0 [M+H-Boc]+, ESI pos.

Step 3: 3-(difluoromethyl)-4,5-dimethyl-pyrazole-l -carboxylic acid tert-butyl ester

3-formyl-4,5-dimethyl-pyrazole-l-carboxylic acid tert-butyl ester (956 mg, 4.26 mmol, 1.0 eq) was dissolved in DCM (20 mL) and cooled to -78°C. DAST (4.12 g, 3.38 mL, 25.58 mmol, 6.0 eq) was added and the reaction mixture was stirred for 1 hour at -78°C before it was warmed to RT and stirred for 16 hours. The reaction mixture was diluted with saturated aqueous NaHCCL (50 mL) and extracted with DCM (3 x 30 mL). The combined organic layers were dried over Na2SO4, filtered and concentrated to give 3-(difluoromethyl)-4,5-dimethyl-pyrazole-l-carboxylic acid tert-butyl ester (1.05 g, quant, yield) which was used without further purification. LC-MS: m/z = 147.0 [M+H-Boc]+, ESI pos.

Step 3: 3-(difluoromethyl)-4,5-dimethyl-lH-pyrazole

3-(difluoromethyl)-4,5-dimethyl-pyrazole-l-carboxylic acid tert-butyl ester (1.05 g, 4.26 mmol, 1.0 eq) was dissolved in DCM (14 mL) and TFA (3.28 mL, 42.64 mmol, 10 eq) was added. The reaction mixture was stirred at RT for 2 hours. The solvent was removed under reduced pressure and the crude product was purified by flash chromatography (SiCh, 10-50% EtOAc in heptane) to give 3-(difluoromethyl)-4,5-dimethyl-lH-pyrazole (381 mg, 2.60 mmol, 61% yield) as a colorless oil. LC-MS: m/z = 147.0 [M+H]+, ESI pos.

Step 3: l-[ 6-chloro-2-[ 3-(difluoromethyl)-4, 5-dimethyl-pyrazol-l-yl ]-3-pyridyl ethanone

To a solution of 3-(difluoromethyl)-4,5-dimethyl-lH-pyrazole (152 mg, 1.04 mmol, 1.2 eq ) in DMF (2.88 mL) was added l-(6-chloro-2-fluoro-3-pyridyl)ethanone (150 mg, 0.864 mmol, 1.0 eq) and CS2CO3 (563 mg, 1.73 mmol, 2.000 eq). The reaction mixture was stirred at RT for 16 hours. The reaction mixture was diluted with H2O (50 mL) and extracted with EtOAv (3 x 50 mL). The combined organic layers were washed with brine (30 mL), dried over Na2SO4, filtered and concentrated. The residue was purified by flash chromatography (SiCL, 0-100% EtOAc in heptane) to give l-[6-chloro-2-[3-(difluoromethyl)-4,5-dimethyl-pyrazol-l-yl] -3- pyridyl] ethanone (118 mg, 0.328 mmol, 38%) as an off white powder. LC-MS: m/z = 300.0 [M+H]+, ESI pos. 'HNMR (600 MHz, DMSO-d6) 5 ppm 8.17 (d, J= 8.1 Hz, 1 H), 7.77 (d, J= 8.1 Hz, 1 H), 6.89 - 7.09 (m, 1 H), 2.43 (s, 3 H), 2.17 (s, 1 H), 2.12 (s, 3 H), 2.10 (s, 1 H), 2.01 (s, 3 H)

Enzymatic Activity Assay:

Assay description SIK1-3, RapidFire:

In the presence of SIK2 (resp. SIK1 or SIK3) and ATP the CHK-peptide (KKKVSRSGLYRSPSMPENLNRPR with C-terminal arginine amide modification) were phosphorylated at one of the four feasible serine’s. Only one phosphorylation is observed under the assay conditions. 60nl of each compound dilution series (12 point; dilution factor 3, generally 30 pM to 170 pM) in DMSO were transferred by acoustic dispensing to the assay plate and 30 min pre-incubated (ambient temperature) after the addition of 5 pl SIK1 (5 nM) resp. 5 pl SIK2 (0.5 nM) or 7 pl SIK3 (1.5 nM) in assay-buffer (12.5 mM HEPES (pH 7.0), 10 mM magnesium acetate, 0.005% BSA). 10 pM CHK-peptide solution and 5 pl 100 pM ATP for SIK1 & SIK2 resp. 3 pl for SIK3 in assay-buffer were added and incubated ambient for 45 min. 40 pl 0.125% formic acid in water were added to quench the reaction. RapidFire (RF) Mass Spectrometry was utilized for data generation as described below. The multiple charged species (3-5 charges) for the phosphorylated and non-phosphorylated form measured by MRM (Multiple Reaction Monitoring; API5000 or 6500+) or EIC (Extracted Ion Current; QToF) were summed up and the ratio calculated (sum phosphorylated species / sum all species) for data evaluation.

Normalization was performed by Genedata software based on the non-inhibition control DMSO and the commercially available SIK inhibitor @ IpM YKL-05-099 (CAS number 1936529-65- 5). The results of the assay are expressed in half-maximal inhibitory concentrations (IC50s) and are summarized below in Table 1.

RapidFire Setup:

Samples were aspirated by vacuum for max. 600ms and loaded to C4-cartridge (Agilent;

#G9203A) for 3000ms@1.5ml/min with 0.1% formic acid in water. Afterwards samples were transferred to the API5000 (API6500+) or QToF mass spectrometer for 4000ms@1.25ml/min with 90% acetonitrile; 10% water; 0.007% TFA; 0.093 formic acid. The cartridge was reconditioned for additional 500ms with 0.1% formic acid in water

MS-Setup Sciex API5000/API6500+:

All MS analyses using the following MS-setup in MRM mode: Electrospray positive; Ion Spray Voltage: 4000V; Temperature: 550°C; Collision Gas: 5; Curtain Gas: 15; Gasl : 40; Gas 2: 42; EP: 10

MS-Setup Agilent QToF 6545

All MS analyses using the following MS-setup in Mode MS: Dual AJS Electrospray positive;

VCap: 3000V; Drying & Sheath gas: 340°C@81/min; Nebulizer: 60psig; Nozzle Voltage: 2000V; Fragmentor: 130V; Skimmer: 35V; Octi RF Vpp: 700V; Ref masses on@5spectra/s

Table 1: IC50 values for inhibition of SIK1, SIK2, and SIK3:

Specific numbered embodiments

1. A compound of formula (I) wherein R ¹ is hydrogen or halogen;

R ² and R ² ’ are independently selected from hydrogen, alkyl, cyclopropyl, haloalkyl and alkoxy alkyl;

Al is -O-, -NR ⁶ -, -(C=O)- or a bond;

R ⁶ is hydrogen or alkyl; R ³ is hydroxyalkyl, heterocycloalkyl, heteroaryl, phenyl or cycloalkylalkyl, wherein heterocycloalkyl, heteroaryl, phenyl and cycloalkylalkyl are optionally substituted with 1, 2 or 3 substituents independently selected from R ⁷ ; if Al is -(C=O)-, then R ³ can also be haloalkylamino; each R ⁷ is independently selected from alkoxy, alkylamino, alkyl, aminocarbonyl, amino, cyano, cycloalkylamino, haloalkyl, halocycloalkyl, halogen, heteroaryl, hydroxycarbonylamino, alkoxyalkyl, alkylaminocarbonyl, alkylsulfonyl, alkoxycarbonimidoyl, aminocarbonyl, hydroxy, cycloalkylalkyl, haloalkoxy, heterocycloalkyl and cycloalkyl;

A2 is -O-, -NH- or a bond; R ⁴ is hydrogen, alkyl, haloalkyl, alkoxyalkyl, dialkylaminoalkyl, cycloalkyl, cycloalkylcarbonyl, aryl, heteroaryl, heteroarylalkyl, heterocycloalkyl or heterocycloalkylalkyl; wherein aryl, cycloalkyl, heteroaryl, heteroarylalkyl, heterocycloalkyl and heterocycloalkylalkyl are optionally substituted with 1, 2 or 3 substituents independently selected from R ⁸ ; if A2 is a bond, then R ⁴ can also be halogen or cyano; each R ⁸ is independently selected from alkyl, halogen, cyano, alkylsulfonyl, alkylaminocarbonyl, heterocycloalkyl and alkoxyheterocycloalkylalkyl;

A3 is -O-, -NR ¹⁰ - or a bond;

R ⁵ is hydrogen, alkyl, alkylsulfonyl, cycloalkylcarbonyl, heterocycloalkylalkyl, heterocycloalkylalkylcarbonyl, aryl, heteroaryl or heterocycloalkyl, wherein cycloalkylcarbonyl, aryl, heteroaryl and heterocycloalkyl are optionally substituted with 1, 2 or 3 substituents independently selected from R ⁹ ; if A3 is a bond, then R ⁵ can also be halogen or cyano; each R ⁹ is independently selected from alkoxy, halogen, dialkylaminocarbonyl, alkyl, alkoxyalkoxy, alkoxyheterocycloalkylalkyl, alkoxyheterocycloalkylcarbonyl, haloalkyl, haloalkoxy, heterocycloalkylalkoxy, heterocycloalkyl, heterocycloalkyloxy, hydroxy, hydroxyalkyl, alkylheterocycloalkyl, (haloalkyl)cycloalkyl, alkylheterocycloalkylalkyl, heterocycloalkylalkyl, alkylsulfonyl, (alkyl)heterocycloalkyl, alkylheterocycloalkyloxy, heterocycloalkylheterocycloalkyl, heterocycloalkylheterocycloalkyl, CH3-O-(CH2-CH2-O) _n -, alkylaminocarbonyl and cyano; wherein n is selected from 5, 6, 7, 8 and 9; and

R ¹⁰ is hydrogen or alkyl carbonyl; or a pharmaceutically acceptable salt thereof.

2. A compound of formula (I) wherein

R ¹ is hydrogen or halogen;

R ² and R ² ’ are independently selected from hydrogen, alkyl, cyclopropyl, haloalkyl and alkoxy alkyl;

Al is -O-, -NR ⁶ -, -(C=O)- or a bond;

R ⁶ is hydrogen or alkyl;

R ³ is alkyl, hydroxyalkyl, heterocycloalkyl, heteroaryl, phenyl or cycloalkylalkyl, wherein heterocycloalkyl, heteroaryl, phenyl and cycloalkylalkyl are optionally substituted with 1, 2 or 3 substituents independently selected from R ⁷ ; if Al is -(C=O)-, then R ³ can also be haloalkylamino; each R ⁷ is independently selected from alkoxy, alkylamino, alkyl, aminocarbonyl, amino, cyano, cycloalkylamino, haloalkyl, halocycloalkyl, halogen, heteroaryl, hydroxycarbonylamino, alkoxyalkyl, alkylaminocarbonyl, alkylsulfonyl, alkoxycarbonimidoyl, aminocarbonyl, hydroxy, cycloalkylalkyl, haloalkoxy, heterocycloalkyl and cycloalkyl;

A2 is -O-, -NH- or a bond;

R ⁴ is hydrogen, alkyl, haloalkyl, alkoxyalkyl, dialkylaminoalkyl, cycloalkyl carbonyl, heteroaryl, heteroarylalkyl, heterocycloalkyl or heterocycloalkylalkyl; wherein heteroaryl, heteroarylalkyl, heterocycloalkyl and heterocycloalkylalkyl are optionally substituted with 1, 2 or 3 substituents independently selected from R ⁸ ; if A2 is a bond, then R ⁴ can also be halogen or cyano; each R ⁸ is independently selected from alkyl, halogen, cyano, alkylsulfonyl, alkylaminocarbonyl, heterocycloalkyl and alkoxyheterocycloalkylalkyl;

A3 is -O-, -NH- or a bond;

R ⁵ is hydrogen, alkyl, alkylsulfonyl, cycloalkylcarbonyl, heterocycloalkylalkyl, heterocycloalkylalkylcarbonyl, heteroaryl or heterocycloalkyl, wherein heteroaryl and heterocycloalkyl are optionally substituted with 1, 2 or 3 substituents independently selected from R ⁹ ; if A3 is a bond, then R ⁵ can also be halogen or cyano; each R ⁹ is independently selected from alkoxy, halogen, dialkylaminocarbonyl, alkyl, alkoxyalkoxy, alkoxyheterocycloalkylalkyl, alkoxyheterocycloalkylcarbonyl, haloalkyl, haloalkoxy, heterocycloalkylalkoxy, heterocycloalkyl, heterocycloalkyl oxy, hydroxy, alkylheterocycloalkyl, alkylheterocycloalkylalkyl, heterocycloalkylalkyl, alkylsulfonyl, (alkyl)heterocycloalkyl, alkylheterocycloalkyloxy, heterocycloalkylheterocycloalkyl, heterocycloalkylheterocycloalkyl, CH3-O-(CH2-CH2-O) _n -, alkylaminocarbonyl and cyano; wherein n is selected from 5, 6, 7, 8 and 9; or a pharmaceutically acceptable salt thereof.

3. A compound according to embodiment 1 or 2, wherein R ¹ is hydrogen or chloro.

4. A compound according to embodiment 1 to 3, wherein R ¹ is hydrogen.

5. A compound according to any one of embodiments 1 to 4, wherein R ¹ is halogen, in particular chloro.

6. A compound according to any one of embodiments 1 to 5, wherein R ² and R ² ’ are independently selected from hydrogen, methyl, ethyl, cyclopropyl, difluoromethyl, trifluoromethyl and methoxymethyl.

7. A compound according to any one of embodiments 1 to 6, wherein R ² and R ² ’ are independently selected from hydrogen, methyl, difluoromethyl, trifluoromethyl and methoxymethyl.

8. A compound according to any one of embodiments 1 to 7, wherein R ² is hydrogen and R ² ’ is independently selected from hydrogen, methyl, ethyl, cyclopropyl, difluoromethyl, trifluoromethyl and methoxymethyl. 9. A compound according to any one of embodiments 1 to 8, wherein R ² is alkyl and R ² ’ is hydrogen.

10. A compound according to any one of embodiments 1 to 9, wherein R ² is methyl and R ² ’ is hydrogen.

11. A compound according to any one of embodiments 1 to 10, wherein Al is -O-, -NR ⁶ - or a bond.

12. A compound according to any one of embodiments 1 to 10, wherein Al is -O- or a bond.

13. A compound according to any one of embodiments 1 to 10, wherein Al is -O-.

14. A compound according to any one of embodiments 1 to 10, wherein Al is a bond.

15. A compound according to any one of embodiments 1 to 10, wherein Al is -NR ⁶ -.

16. A compound according to any one of embodiments 1 to 10, wherein Al is -(C=O)-.

17. A compound according to any one of embodiments 1 to 16, wherein R ⁶ is hydrogen or methyl.

18. A compound according to any one of embodiments 1 to 17, wherein R ⁶ is hydrogen.

19. A compound according to any one of embodiments 1 to 18, wherein R ³ is methyl, ethyl, butyl, pentyl, hydroxypentyl, hydroxybutyl, phenyl, cyclopropylmethyl, heterocycloalkyl or heteroaryl, and wherein phenyl, heterocycloalkyl and heteroaryl are optionally substituted with 1, 2 or 3 substituents independently selected from R ⁷ ; if Al is -(C=O)-, then R ³ can also be tri fluoroethylamino; each R ⁷ is independently selected from aminocarbonyl, amino, cyano, methoxy, ethoxy, chloro, fluoro, hydroxy, trifluoromethyl, trifluoroethyl, difluoromethyl, methylsulfonyl, methylaminocarbonyl, methoxy ethyl, cyclopropylamino, difluoromethoxy, oxetan-3-yl, methylamino, lH-pyrazol-4-yl, difluorocyclopropyl, methyl, ethyl, cyclopropylmethyl and cyclobutylmethyl .

20. A compound according to any one of embodiments 1 to 18, wherein R ³ is hydroxypentyl, hydroxybutyl, phenyl, cyclopropylmethyl, heterocycloalkyl or heteroaryl, and wherein phenyl, heterocycloalkyl and heteroaryl are optionally substituted with 1, 2 or 3 substituents independently selected from R ⁷ ; if Al is -(C=O)-, then R ³ can also be trifluoroethylamino; each R ⁷ is independently selected from aminocarbonyl, amino, cyano, methoxy, ethoxy, chloro, fluoro, hydroxy, trifluoromethyl, trifluoroethyl, difluoromethyl, methylsulfonyl, methylaminocarbonyl, methoxy ethyl, cyclopropylamino, difluoromethoxy, oxetan-3-yl, methylamino, lH-pyrazol-4-yl, difluorocyclopropyl, methyl, ethyl, cyclopropylmethyl and cyclobutylmethyl .

21. A compound according to any one of embodiments 1 to 20, wherein R ³ is methyl, ethyl, butyl, pentyl, hydroxypentyl, hydroxybutyl, phenyl, cyclopropylmethyl, heterocycloalkyl or heteroaryl, and wherein phenyl, heterocycloalkyl and heteroaryl are optionally substituted with 1, 2 or 3 substituents independently selected from R7; and wherein each R ⁷ is independently selected from aminocarbonyl, amino, cyano, methoxy, ethoxy, chloro, fluoro, hydroxy, trifluoromethyl, trifluoroethyl, difluoromethyl, methylsulfonyl, methylaminocarbonyl, methoxy ethyl, cyclopropylamino, difluoromethoxy, ox etan-3 -yl, methylamino, lH-pyrazol-4-yl, difluorocyclopropyl, methyl, ethyl, cyclopropylmethyl and cyclobutylmethyl .

22. A compound according to any one of embodiments 1 to 21, wherein R ³ is haloalkylamino.

23. A compound according to any one of embodiments 1 to 22, wherein the heterocycloalkyl of substituent R ³ is selected from morpholino, pyrrolidinyl, piperidyl, 2-oxopyrrolidinyl, (1,1- dioxo-l,2-thiazolidinyl), (4,5,6,7-tetrahydropyrazolo[4,3-c]pyridinyl), pyrrolidinyl, [rac- (3aR,6aS)-2,3,3a,5,6,6a-hexahydro-lH-pyrrolo[3,2-b]pyrrolyl] , [rac-(3aS,6aR)-2,3,3a,5,6,6a- hexahydro-lH-pyrrolo[3,2-b]pyrrolyl], [3-oxo-piperazinyl], (4-oxo-6,7-dihydro-5H- pyrazolo[l,5-a]pyrazinyl), (6,7-dihydro-4H-pyrazolo[4,3-c]pyridinyl), azetidinyl, pyrrolidinyl, (3-oxo-l,5,6,8-tetrahydrooxazolo[3,4-a]pyrazinyl), piperazinyl, 4,7-diazaspiro[2.5]octanyl, (2- oxa-5,8-diazaspiro[3.5]nonanyl), 3-azabicyclo[3.2.0]heptanyl), (5-azaspiro[2.4]heptanyl), (2- azabicyclo[2.2.1]heptanyl), morpholinyl, 4-oxa-7-azaspiro[2.5]octanyl, (3- azabicyclo[3.1.0]hexanyl), (6,7-dihydro-4H-pyrazolo[4,3-c]pyridinyl), 5,6-dihydro-4H- pyrazolo[4,3-c]pyridin-l-yl, 6-azaspiro[3.4]octan-6-yl and 2-oxa-7-azaspiro[3.4]octanyl.

24. A compound according to any one of embodiments 1 to 23, wherein the heteroaryl of substituent R ³ is selected from 2-oxo-pyridyl, 2-oxo-3-imidazol-l-yl, l,2,4-triazol-3-yl, pyrazolyl, pyridyl, pyridazinyl, isoxazolyl, pyrimidinyl, IH-benzotriazolyl, furyl, [6-oxo-lH- pyridazinyl] and triazolyl.

25. A compound according to any one of embodiments 1 to 24, wherein the heterocycloalkyl of substituent R ³ is selected from morpholino, pyrrolidinyl, piperidyl, 2-oxopyrrolidinyl, (1,1- dioxo-l,2-thiazolidinyl), (4,5,6,7-tetrahydropyrazolo[4,3-c]pyridinyl), pyrrolidinyl, [rac- (3aR,6aS)-2,3,3a,5,6,6a-hexahydro-lH-pyrrolo[3,2-b]pyrrolyl] , [rac-(3aS,6aR)-2,3,3a,5,6,6a- hexahydro-lH-pyrrolo[3,2-b]pyrrolyl], [3-oxo-piperazinyl], (4-oxo-6,7-dihydro-5H- pyrazolo[l,5-a]pyrazinyl), (6,7-dihydro-4H-pyrazolo[4,3-c]pyridinyl), azetidinyl, pyrrolidinyl, (3-oxo-l,5,6,8-tetrahydrooxazolo[3,4-a]pyrazinyl), piperazinyl, 4,7-diazaspiro[2.5]octanyl, (2- oxa-5,8-diazaspiro[3.5]nonanyl), 3-azabicyclo[3.2.0]heptanyl), (5-azaspiro[2.4]heptanyl), (2- azabicyclo[2.2.1]heptanyl), morpholinyl, 4-oxa-7-azaspiro[2.5]octanyl, (3- azabicyclo[3.1.0]hexanyl), (6,7-dihydro-4H-pyrazolo[4,3-c]pyridinyl) and 2-oxa-7- azaspiro[3.4]octanyl; and wherein the heteroaryl of substituent R ³ is selected from 2-oxo-pyridyl, pyrazolyl, pyridyl, pyridazinyl, isoxazolyl, pyrimidinyl, IH-benzotriazolyl, furyl, [6-oxo-lH-pyridazinyl] and triazolyl.

26. A compound according to any one of embodiments 1 to 25, wherein the heterocycloalkyl of substituent R ³ is selected from morpholino, pyrrolidin-l-yl, 1-piperidyl, 2-oxopyrrolidin-l-yl, (l,l-dioxo-l,2-thiazoli din-2 -yl), (4,5,6,7-tetrahydropyrazolo[4,3-c]pyridin-l-yl), [rac-(3aR,6aS)- 2,3,3a,5,6,6a-hexahydro-lH-pyrrolo[3,2-b]pyrrol-4-yl], [rac-(3aS,6aR)-2,3,3a,5,6,6a-hexahydro- lH-pyrrolo[3,2-b]pyrrol-4-yl], [3-oxo-piperazin-l-yl], (4-oxo-6,7-dihydro-5H-pyrazolo[l,5- a]pyrazin-3-yl), (6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-l-yl), azetidin-l-yl, pyrrolidin-3-yl, (3- oxo-l,5,6,8-tetrahydrooxazolo[3,4-a]pyrazin-7-yl), piperazin- 1-yl, (4,7-diazaspiro[2.5]octan-7- yl), (2-oxa-5,8-diazaspiro[3.5]nonan-8-yl), 3-azabicyclo[3.2.0]heptan-3-yl), (5- azaspiro[2.4]heptan-5-yl), (2-azabicyclo[2.2.1]heptan-2-yl), morpholin-4-yl, 4-oxa-7- azaspiro[2.5]octan-7-yl, (3-azabicyclo[3.1.0]hexan-3-yl), (6,7-dihydro-4H-pyrazolo[4,3- c]pyridin-l-yl) and 2-oxa-7-azaspiro[3.4]octan-7-yl; and wherein the heteroaryl substituent of R ³ is selected from 2-oxo-4-pyridyl, pyrazol-l-yl, pyrazol- 3-yl, 3-pyridyl, pyridazin-4-yl, pyrazol-4-yl, isoxazol-4-yl, 4-pyridyl, pyrimidin-5-yl, 1H- benzotriazol-4-yl, 3-furyl, [6-oxo-lH-pyridazin-5-yl], 2-furyl, triazol-2-yl, triazol-4-yl and triazol-l-yl. 27. A compound according to any one of embodiments 1 to 26, wherein R ³ is cycloalkylalkyl, heterocycloalkyl or heteroaryl, wherein heterocycloalkyl, heteroaryl and cycloalkylalkyl are optionally substituted with 1, 2 or 3 substituents independently selected from R7; and wherein each R ⁷ is independently selected from alkyl, cyano, haloalkyl, alkoxy, alkylsulfonyl, alkoxycarbonimidoyl and haloalkyloxy.

28. A compound according to any one of embodiments 1 to 27, wherein R ³ is cyclopropylmethyl, heterocycloalkyl or heteroaryl, wherein heterocycloalkyl, heteroaryl and cycloalkylalkyl are optionally substituted with 1, 2 or 3 substituents independently selected from R ⁷ ; and wherein each R ⁷ is independently selected from methyl, cyano, trifluoromethyl, difluoromethyl, trifluoroethyl, ethoxy, methoxy, methyl sulfonyl, methoxycarbonimidoyl, difluoroethoxy and oxetan-3-yl.

29. A compound according to any one of embodiments 1 to 28, wherein the heterocycloalkyl of substituent R ³ is selected from (4,5,6,7-tetrahydropyrazolo[4,3-c]pyridin-l-yl), pyrrolidin-l-yl, [rac-(3aR,6aS)-2,3,3a,5,6,6a-hexahydro-lH-pyrrolo[3,2-b]pyrr ol-4-yl], [3-oxo-piperazin-l-yl], and (6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-l-yl); and wherein the heteroaryl of substituent R ³ is selected from pyrazol-l-yl, pyrazol-3-yl, pyrazol-4-yl, 3-pyridyl, 4-pyridyl, triazol-l-yl and triazol-4-yl.

30. A compound according to any one of embodiments 1 to 29, wherein R ³ is pyrazol-l-yl, pyrazol-3-yl or pyrazol-4-yl, and wherein pyrazol-l-yl, pyrazol-3-yl and pyrazol-4-yl are optionally substituted with 1, 2 or 3 substituents independently selected from R ⁷ ; and wherein each R ⁷ is independently selected from methyl, cyano, trifluoromethyl, difluoromethyl, trifluoroethyl, ethoxy, methoxy, difluoroethoxy and methyl sulfonyl.

31. A compound according to any one of embodiments 1 to 30, wherein

A2 is -O-, -NH- or a bond;

R ⁴ is hydrogen, haloalkyl, alkoxyalkyl, dialkylaminoalkyl, cycloalkyl, cycloalkylcarbonyl, aryl, heteroaryl, heteroarylalkyl, heterocycloalkyl or heterocycloalkylalkyl; wherein aryl, cycloalkyl, heteroaryl, heteroarylalkyl, heterocycloalkyl and heterocycloalkylalkyl are optionally substituted with 1, 2 or 3 substituents independently selected from R ⁸ ; if A2 is a bond, then R ⁴ can also be halogen or cyano; if A2 is -O- or -NH-, then R ⁴ can also be alkyl; each R ⁸ is independently selected from alkyl, halogen, cyano, alkylsulfonyl, alkylaminocarbonyl, heterocycloalkyl and alkoxyheterocycloalkylalkyl;

A3 is -O-, -NH- or a bond;

R ⁵ is hydrogen, alkylsulfonyl, cycloalkylcarbonyl, heterocycloalkylalkyl, heterocycloalkylalkylcarbonyl, aryl, heteroaryl or heterocycloalkyl, wherein aryl, cycloalkylcarbonyl, heteroaryl and heterocycloalkyl are optionally substituted with 1, 2 or 3 substituents independently selected from R ⁹ ; if A3 is a bond, then R ⁵ can also be halogen or cyano; if A3 is -O- or -NH-, then R ⁵ can also be alkyl; each R ⁹ is independently selected from alkoxy, halogen, dialkylaminocarbonyl, alkyl, alkoxyalkoxy, alkoxyheterocycloalkylalkyl, alkoxyheterocycloalkylcarbonyl, haloalkyl, haloalkoxy, heterocycloalkylalkoxy, heterocycloalkyl, heterocycloalkyl oxy, hydroxy, alkylheterocycloalkyl, alkylheterocycloalkylalkyl, heterocycloalkylalkyl, alkylsulfonyl, (alkyl)heterocycloalkyl, alkylheterocycloalkyloxy, heterocycloalkylheterocycloalkyl, heterocycloalkylheterocycloalkyl, CH3-O-(CH2-CH2-O) _n -, alkylaminocarbonyl and cyano; wherein n is selected from 5, 6, 7, 8 and 9; with the proviso that only one of R ⁴ and R ⁵ can be hydrogen.

32. A compound according to any one of embodiments 1 to 31, wherein A2 is -O- or a bond.

33. A compound according to any one of dmbodiments 1 to 32, wherein A2 is -O-.

34. A compound according to any one of embodiments 1 to 31, wherein A2 is a bond.

35. A compound according to any one of embodiments 1 to 31, wherein A2 is -NH-.

36. A compound according to any one of embodiments 1 to 35, wherein R ⁴ is hydrogen, trifluoromethyl, methoxyethyl, dimethylaminoethyl, cyclopropylcarbonyl, morpholinoethyl, (1,1- dioxo-l,2-thiazolidin-2-yl)methyl, (2-oxopyrrolidin-l-yl)methyl, (2-oxo-l-piperidyl)m ethyl,

(ox etan-3 -yl)methyl, phenyl, heteroaryl or heterocycloalkyl, and wherein phenyl, heteroaryl and heterocycloalkyl are optionally substituted with 1, 2 or 3 substituents independently selected from R ⁸ ; if A2 is a bond, then R ⁴ can also be fluoro, bromo or cyano; if A2 is -O- or -NH-, then R ⁴ can also be methyl; each R ⁸ is independently selected from methyl, fluoro, cyano, 2-oxopyrrolidin-l-yl, methylsulfonyl, oxetan-3-yl and (3-methoxyazetidin-l-yl)methyl.

37. A compound according to any one of embodiments 1 to 36, wherein R ⁴ is hydrogen, trifluoromethyl, methoxyethyl, dimethylaminoethyl, cyclopropyl carbonyl, morpholinoethyl, (1,1- dioxo-l,2-thiazolidin-2-yl)methyl, (2-oxopyrrolidin-l-yl)methyl, (2-oxo-l-piperidyl)m ethyl, heteroaryl or heterocycloalkyl, and wherein heteroaryl and heterocycloalkyl are optionally substituted with 1, 2 or 3 substituents independently selected from R ⁸ ; if A2 is a bond, then R ⁴ can also be fluoro, bromo or cyano; if A2 is -O- or -NH-, then R ⁴ can also be methyl.

38. A compound according to any one of embodiments 1 to 37, wherein R ⁴ is hydrogen, trifluoromethyl, methoxyethyl, dimethylaminoethyl, cyclopropylcarbonyl, morpholinoethyl, (1,1- dioxo-l,2-thiazolidin-2-yl)methyl, (2-oxopyrrolidin-l-yl)methyl, (2-oxo-l-piperidyl)m ethyl, heteroaryl or heterocycloalkyl, wherein heteroaryl and heterocycloalkyl are optionally substituted with 1, 2 or 3 substituents independently selected from R ⁸ ; if A2 is a bond, then R ⁴ can also be fluoro, bromo or cyano; if A2 is -O-, then R ⁴ can also be methyl; each R ⁸ is independently selected from methyl, fluoro, cyano, methylsulfonyl, oxetan-3-yl and (3 -methoxyazetidin- 1 -yl)methyl .

39. A compound according to any one of embodiments 1 to 38, wherein the heterocycloalkyl of substituent R ⁴ is selected from piperidyl, piperazinyl, pyrrolidinyl, 2,3-dihydropyridazino[4,5- b][l,4]oxazinyl, pyrrolidinyl, 2-oxo-pyrimidinyl, 6,7-dihydro-5H-cyclopenta[c]pyridazin-3-yl, 7- oxo-5H-pyrrolo[3,4-b]pyridin-2-yl, 2-oxa-5-azaspiro[3.4]octanyl and oxetanyl; and wherein the heteroaryl of substituent R ⁴ is selected from 2-oxazol-5-yl, pyridazinyl and pyridyl.

40. A compound according to any one of embodiments 1 to 39, wherein the heterocycloalkyl of substituent R ⁴ is selected from 4-piperidyl, piperazin- 1-yl, pyrrolidin-3-yl, 2,3- dihydropyridazino[4,5-b][l,4]oxazin-8-yl, pyrrolidin-l-yl, 2-oxo-pyrimidin-4-yl, 2-oxa-5- azaspiro[3.4]octan-5-yl, [rac-(3aS,6aS)-6-oxo-2,3,3a,4,5,6a-hexahydropyrrolo[2,3-c]py rrol-l-yl] and oxetan-3-yl; and wherein the heteroaryl of substituent R ⁴ is selected from pyridazin-3-yl and 3-pyridyl. 41. A compound according to any one of embodiments 1 to 40, wherein R ⁴ is selected from hydrogen, alkoxyalkyl, dialkylaminoalkyl and heterocycloalkyl; if A2 is a bond, then R ⁴ can also be halogen; if A2 is -O- or -NH-, then R ⁴ can also be alkyl.

42. A compound according to any one of embodiments 1 to 41, wherein R ⁴ is selected from hydrogen, methoxyethyl, dimethylaminoethyl and pyrrolidin-3-yl; if A2 is a bond, then R ⁴ can also be fluoro; if A2 is -O-, then R ⁴ can also be methyl.

43. A compound according to any one of embodiments 1 to 42, wherein R ⁴ is selected from methoxyethyl, dimethylaminoethyl and pyrrolidin-3-yl; if A2 is a bond, then R ⁴ can also be fluoro; if A2 is -O-, then R ⁴ can also be methyl.

44. A compound according to any one of embodiments 1 to 43, wherein R ⁴ is hydrogen.

45. A compound according to any one of embodiments 1 to 44, wherein R ⁴ is phenyl optionally substituted with one, two or three substituents independently selected from R ⁸ .

46. A compound according to any one of embodiments 1 to 45, wherein each R ⁸ is independently selected from methyl, fluoro, cyano, methylsulfonyl, oxetan-3-yl and (3-methoxyazetidin-l- yl)methyl.

47. A compound according to any one of embodiments 1 to 46, wherein A3 is -O- or -NH-.

48. A compound according to any one of embodiments 1 to 47, wherein A3 is -O-.

49. A compound according to any one of embodiments 1 to 47, wherein A3 is -NH-.

50. A compound according to any one of embodiments 1 to 46, wherein A3 is a bond.

51. A compound according to any one of embodiments 1 to 50, wherein n is 7.

52. A compound according to any one of embodiments 1 to 51, wherein R ⁵ is hydrogen, methylsulfonyl, morpholinoethyl, (2-oxopyrrolidin-l-yl)methyl, (2-oxo-l-piperidyl)m ethyl, (ox etan-3 -yl)methyl, 1 -piperidyl ethylcarbonyl, phenyl, heteroaryl or heterocycloalkyl; wherein phenyl, heteroaryl and heterocycloalkyl are optionally substituted with 1, 2 or 3 substituents independently selected from R ⁹ ; if A3 is a bond, then R ⁵ can also be fluoro or cyano; if A3 is -O- or -NH-, then R ⁵ can also be methyl; and wherein each R ⁹ is independently selected from methyl, methoxy, oxetan-3-yl, azeti din-3 -yl, azetidin-l-yl, 3,3-difluoroazetidin-l-yl, 2-oxopyrrolidin-l-yl, hydroxy, difluoromethyl, trifluoromethyl, (3 -methoxyazetidin- 1 -yl)m ethyl, 3 -methoxyazetidine- 1 -carbonyl, methoxyethoxy, difluoroethoxy, difluoromethoxy, [2-(l,l-dioxo-l,4-thiazinan-4-yl)ethoxy], oxetan-3-yloxy, chloro, dimethylaminocarbonyl, cyano, methylsulfonyl, morpholinomethyl, morpholino, (4-methylpiperazin-l-yl)methyl, CH3-O-(CH2-CH2-O)?-, ox etan-3 -yl, [l-(oxetan-3- yl)pyrrolidin-2-yl] and (2-methyl-l,3-dioxolan-2-yl).

53. A compound according to any one of embodiments 1 to 52, wherein R ⁵ is hydrogen, methylsulfonyl, morpholinoethyl, (2-oxopyrrolidin-l-yl)methyl, (2-oxo-l-piperidyl)m ethyl, 1- piperidylethylcarbonyl, heteroaryl or heterocycloalkyl; wherein heteroaryl and heterocycloalkyl are optionally substituted with 1, 2 or 3 substituents independently selected from R ⁹ ; if A3 is a bond, then R ⁵ can also be fluoro or cyano; if A3 is -O- or -NH-, then R ⁵ can also be methyl.

54. A compound according to any one of embodiments 1 to 53, wherein the heterocycloalkyl of substituent R ⁵ is selected from piperazinyl, pyrrolidinyl, piperidyl, 2-oxo-piperidyl, 5-oxo- pyrrolidinyl, (l,l-dioxo-l,2-thiazolidinyl), oxetanyl, 2-oxa-5-azaspiro[3.4]octanyl, 7,8-dihydro- 5H-pyrano[4,3-c]pyridazinyl, [rac-(4aS,7aR)-4-methyl-2,3,4a,5,7,7a-hexahydropyrrolo[3,4- b][l,4]oxazinyl] and [rac-(3aS,6aS)-6-oxo-2,3,3a,4,5,6a-hexahydropyrrolo[2,3-c]py rrolyl]), and wherein the heteroaryl of substituent R ⁵ is selected from (pyridazinyl, pyrazolyl, pyridyl, pyrazinyl, pyrimidinyl, (1,3,4-oxadiazolyl), (1,3,4-thiadiazolyl), (1,2,4-triazinyl), isoxazolyl, 2- oxo-pyrimidinyl, l-methyl-2-oxo-pyridyl, 5,6-dihydropyrrolo[2,3-c]pyridazin-7-yl, 2-oxazol-5- yl, 7-oxo-5H-pyrrolo[3,4-b]pyridin-2-yl and (2,3-dihydropyridazino[4,5-b][l,4]oxazinyl)).

55. A compound according to any one of embodiments 1 to 54, wherein the heterocycloalkyl of substituent R ⁵ is selected from piperazin- 1-yl, pyrrolidin-l-yl, 4-piperidyl, 2-oxo-4-piperidyl, 5- oxo-pyrrolidin-3-yl, (l,l-dioxo-l,2-thiazolidin-2-yl), oxetan-3-yl, 2-oxa-5-azaspiro[3.4]octan-5- yl, 7,8-dihydro-5H-pyrano[4,3-c]pyridazin-3-yl, [rac-(4aS,7aR)-4-methyl-2,3,4a,5,7,7a- hexahydropyrrolo[3,4-b][l,4]oxazin-6-yl] and [rac-(3aS,6aS)-6-oxo-2,3,3a,4,5,6a- hexahydropyrrolo[2,3-c]pyrrol-l-yl]), and wherein the heteroaryl of substituent R ⁵ is selected from (pyridazin-3-yl, pyrazol-4-yl, 3 -pyridyl, pyrazin-2-yl, pyrimidin-2-yl, 2-pyridyl, pyrimidin- 5-yl, pyridazin-4-yl, (l,3,4-oxadiazol-2-yl), (l,3,4-thiadiazol-2-yl), (l,2,4-triazin-3-yl), isoxazol- 3-yl, 2-oxo-pyrimidin-4-yl, 1 -m ethyl -2-oxo-3 -pyridyl and (2,3-dihydropyridazino[4,5- b][l,4]oxazin-8-yl)). 56. A compound according to any one of embodiments 1 to 55, wherein R ⁵ is pyrimidin-5-yl or pyridazin-3-yl, wherein pyrimidin-5-yl and pyridazin-3-yl are optionally substituted with 1, 2 or 3 substituents independently selected from R ⁹ .

57. A compound according to any one of embodiments 1 to 56, wherein R ⁵ is pyridazin-3-yl, wherein pyridazin-3-yl is optionally substituted with one substituent selected from R ⁹ .

58. A compound according to any one of embodiments 1 to 57, wherein R ⁵ is pyrimidin-5-yl wherein pyrimidin-5-yl is optionally substituted with one substituent selected from R ⁹ .

59. A compound according to any one of embodiments 1 to 58, wherein R5 is phenyl optionally substituted with one, two or three substituents independently selected from R ⁹ .

60. A compound according to any one of embodiments 1 to 59, wherein each R ⁹ is independently selected from methyl, methoxy, ox etan-3 -yl, azeti din-3 -yl, hydroxy, difluoromethyl, trifluoromethyl, (3 -methoxyazetidin- 1 -yl)m ethyl, 3 -methoxyazetidine- 1 -carbonyl, methoxyethoxy, difluoroethoxy, difluoromethoxy, [2-(l,l-dioxo-l,4-thiazinan-4-yl)ethoxy], oxetan-3-yloxy, fluoro, chloro, dimethylaminocarbonyl, (difluoromethyl)cyclopropyl, cyano, methylsulfonyl, morpholinomethyl, morpholino, (4-methylpiperazin-l-yl)methyl, CH3-O-(CH2- CH2-O)?-, oxetan-3-yl, [l-(oxetan-3-yl)pyrrolidin-2-yl] and (2-methyl-l,3-dioxolan-2-yl).

61. A compound according to any one of embodiments 1 to 60, wherein each R ⁹ is independently selected from methyl, methoxy, difluoromethyl, (3 -methoxyazetidin- l-yl)methyl, methoxyethoxy, difluoroethoxy, difluoromethoxy, [2-(l,l-dioxo-l,4-thiazinan-4-yl)ethoxy], oxetan-3-yloxy, dimethylaminocarbonyl, ox etan-3 -yl, chloro and trifluoromethyl.

62. A compound according to any one of embodiments 1 to 61, with the proviso that only one of R ⁴ and R ⁵ can be hydrogen.

63. A compound according to any one of embodiments 1 to 62, with the proviso that only one of R ⁴ and R ⁵ can be alkyl.

64. A compound according to any one of embodiments 1 to 63, wherein R ¹⁰ is hydrogen.

65. A compound according to any one of embodiments 1 to 64, wherein R ¹⁰ is alkylcarbonyl.

66. A compound according to any one of embodiments 1 to 65, selected from

[2-(3-chlorophenyl)-6-(5,6-dimethoxybenzimidazol-l-yl)-3- pyridyl]methanol; (2-(3-chloro-2-fluorophenyl)-6-(5,6-dimethoxy-lH-benzo[d]imi dazol-l-yl)pyridin-3- yl)methanol;

(6-(5,6-dimethoxy-lH-benzo[d]imidazol-l-yl)-2-(4-fluoro-2 -methoxyphenyl)pyri din-3- yl)methanol; l-(6-(5,6-dimethoxy-lH-benzo[d]imidazol-l-yl)-2-(4-fluoro-2- methoxyphenyl)pyri din-3- yl)ethan-l-ol; l-(6-(5,6-dimethoxy-lH-benzo[d]imidazol-l-yl)-2-(4-fluoro-2- methoxyphenyl)pyri din-3- yl)propan-l-ol;

1 -(2-(3 -chlorophenyl)-6-(5,6-dimethoxy- lH-benzo[d]imidazol- 1 -yl)pyri din-3 -yl)ethan- 1 -ol; l-(2-(3-chloro-2-fluorophenyl)-6-(5,6-dimethoxy-lH-benzo[d]i midazol-l-yl)pyridin-3-yl)ethan- l-ol;

(S)-l-(6-(5,6-dimethoxy-lH-benzo[d]imidazol-l-yl)-2-(4-fl uoro-2-methoxyphenyl)pyri din-3- yl)ethan-l-ol;

(R)-l-(6-(5,6-dimethoxy-lH-benzo[d]imidazol-l-yl)-2-(4-fl uoro-2-methoxyphenyl)pyri din-3- yl)ethan-l-ol; cyclopropyl(6-(5,6-dimethoxy-lH-benzo[d]imidazol-l-yl)-2-(4- fluoro-2-methoxyphenyl)pyridin- 3 -yl)m ethanol; l-(2-(3-chlorophenyl)-6-(5,6-dimethoxy-lH-benzo[d]imidazol-l -yl)pyridin-3-yl)propan-l-ol;

(2-(3-chlorophenyl)-6-(5,6-dimethoxy-lH-benzo[d]imidazol- l-yl)pyri din-3- yl)(cyclopropyl)methanol;

(6-(5,6-dimethoxy-lH-benzo[d]imidazol-l-yl)-2-morpholinop yridin-3-yl)methanol;

(6-(5,6-dimethoxy-lH-benzo[d]imidazol-l-yl)-2-(pyrrolidin -l-yl)pyridin-3-yl)methanol;

(6-(5,6-dimethoxy-lH-benzo[d]imidazol-l-yl)-2-(piperidin- l-yl)pyridin-3-yl)methanol;

5-((6-(5,6-dimethoxy-lH-benzo[d]imidazol-l-yl)-3-(hydroxy methyl)pyridin-2-yl)amino)pentan- l-ol; l-(6-(5,6-dimethoxy-lH-benzo[d]imidazol-l-yl)-3-(hydroxymeth yl)pyridin-2-yl)pyrrolidin-2- one;

4-((6-(5,6-dimethoxy- lH-benzo[d]imidazol- 1 -yl)-3-(hydroxymethyl)pyri din-2 -yl)amino)butan- 1 - ol;

(S)-2-(6-(5,6-dimethoxy-lH-benzo[d]imidazol-l-yl)-3-(l-hy droxyethyl)pyridin-2-yl)benzamide;

(R)-2-(6-(5,6-dimethoxy-lH-benzo[d]imidazol-l-yl)-3-(l-hy droxyethyl)pyridin-2-yl)benzamide;

(S)-3-(6-(5,6-dimethoxy-lH-benzo[d]imidazol-l-yl)-3-(l-hy droxyethyl)pyridin-2- yl)benzonitrile;

(R)-3-(6-(5,6-dimethoxy-lH-benzo[d]imidazol-l-yl)-3-(l-hy droxyethyl)pyri din-2- yl)benzonitrile;

(S)-4-(6-(5,6-dimethoxy-lH-benzo[d]imidazol-l-yl)-3-(l-hy droxyethyl)pyridin-2- yl)benzonitrile;

(R)-4-(6-(5,6-dimethoxy-lH-benzo[d]imidazol-l-yl)-3-(l-hy droxyethyl)pyri din-2- yl)benzonitrile;

(S)-6-(5,6-dimethoxy-lH-benzo[d]imidazol-l-yl)-3-(l -hydroxyethyl)- l'-methyl-[2,4'-bipyridin]- 2'(l'H)-one;

(R)-6-(5,6-dimethoxy-lH-benzo[d]imidazol-l-yl)-3-(l-hydro xyethyl)-r-methyl-[2,4'-bipyridin]- 2'(l'H)-one; l-[6-[5-(2-morpholinoethoxy)benzimidazol-l-yl]-2-phenoxy-3-p yridyl]ethanol; l-[2-anilino-6-[5-(2 -morpholinoethoxy )benzimidazol-l-yl]-3-pyridyl]ethanol; l-[6-[5-(2-morpholinoethoxy)benzimidazol-l-yl]-2-[3-(trifluo romethyl)pyrazol-l-yl]-3- pyridyl] ethanol; l-[6-(5,6-dimethoxybenzimidazol-l-yl)-2-[3-(trifluoromethyl) pyrazol-l-yl]-3-pyridyl]ethanol; l-[3-(l-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino]be nzimidazol-l-yl]-2-pyridyl]-5- methyl-pyrazole-3 -carbonitrile; l-[3-(l-hydroxyethyl)-6-[5-(4-methylpiperazin-l-yl)benzimida zol-l-yl]-2-pyridyl]-5-methyl- pyrazole-3 -carbonitrile; l-[3-(l-hydroxyethyl)-6-[5-[4-(oxetan-3-yl)piperazin-l-yl]be nzimidazol-l-yl]-2-pyridyl]-5- methyl-pyrazole-3 -carbonitrile; l-[3-(l-hydroxyethyl)-6-[5-(2 -morpholinoethoxy )benzimidazol-l -yl]-2-pyri dyl]-5-methyl- pyrazole-3 -carbonitrile; l-[3-(l-hydroxyethyl)-6-[5-[[l-(oxetan-3-yl)pyrazol-4-yl]ami no]benzimidazol-l-yl]-2-pyridyl]- 5-methyl-pyrazole-3-carbonitrile; l-[6-[5-[[l-(azetidin-3-yl)pyrazol-4-yl]amino]benzimidazol-l -yl]-3-(l-hydroxyethyl)-2-pyridyl]- 5-methyl-pyrazole-3-carbonitrile; l-[3-(l-hydroxyethyl)-6-[6-(6-methylpyridazin-3-yl)oxybenzim idazol-l-yl]-2-pyridyl]-5-methyl- pyrazole-3 -carbonitrile; l-[3-(l-hydroxyethyl)-6-[5-(6-methylpyridazin-3-yl)oxybenzim idazol-l-yl]-2-pyridyl]-5-methyl- pyrazole-3 -carbonitrile;

5-[3-(l-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino ]benzimidazol-l-yl]-2-pyridyl]-l- methyl-pyrazole-4-carbonitrile; l-[3-(l-hydroxyethyl)-6-[5-[rac-(3R)-3-hydroxypyrrolidin-l-y l]benzimidazol-l-yl]-2-pyridyl]-5- methyl-pyrazole-3 -carbonitrile; l-[3-(l-hydroxyethyl)-6-[5-[(3S)-3-hydroxypyrrolidin-l-yl]be nzimidazol-l-yl]-2-pyridyl]-5- methyl-pyrazole-3 -carbonitrile; l-[3-(l-hydroxyethyl)-6-[5-[(6-methyl-3-pyridyl)amino]benzim idazol-l-yl]-2-pyridyl]-5-methyl- pyrazole-3 -carbonitrile; l-[3-(l-hydroxyethyl)-6-[5-[(5-methylpyrazin-2-yl)amino]benz imidazol-l-yl]-2-pyridyl]-5- methyl-pyrazole-3 -carbonitrile; l-[3-(l-hydroxyethyl)-6-[5-[(5-methylpyrimidin-2-yl)amino]be nzimidazol-l-yl]-2-pyridyl]-5- methyl-pyrazole-3 -carbonitrile; l-[3-(l-hydroxyethyl)-6-[5-[(5-methyl-2-pyridyl)amino]benzim idazol-l-yl]-2-pyridyl]-5-methyl- pyrazole-3 -carbonitrile; l-[2-(l, 1 -di oxo-1, 2-thi azolidin-2 -yl)-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-l-yl]- 3- pyridyl] ethanol; l-[3-(l-hydroxyethyl)-6-[5-[(2-methylpyrimidin-5-yl)amino]be nzimidazol-l-yl]-2-pyridyl]-5- methyl-pyrazole-3 -carbonitrile; l-[3-(l-hydroxyethyl)-6-[5-(pyridazin-4-ylamino)benzimidazol -l-yl]-2-pyridyl]-5-methyl- pyrazole-3 -carbonitrile; l-[3-(l-hydroxyethyl)-6-[5-[(6-methoxypyridazin-3-yl)amino]b enzimidazol-l-yl]-2-pyridyl]-5- methyl-pyrazole-3 -carbonitrile; l-[3-(l-hydroxyethyl)-6-[5-(pyridazin-3-ylamino)benzimidazol -l-yl]-2-pyridyl]-5-methyl- pyrazole-3 -carbonitrile; l-[6-[5-[[6-(difluoromethyl)pyridazin-3-yl]amino]benzimidazo l-l-yl]-3-(l-hydroxyethyl)-2- pyridyl]-5-methyl-pyrazole-3-carbonitrile; l-[6-[6-fluoro-5-[(6-methylpyridazin-3-yl)amino]benzimidazol -l-yl]-3-(l-hydroxyethyl)-2- pyridyl]-5-methyl-pyrazole-3-carbonitrile; l-[6-[5-fluoro-6-[(6-methylpyridazin-3-yl)amino]benzimidazol -l-yl]-3-(l-hydroxyethyl)-2- pyridyl]-5-methyl-pyrazole-3-carbonitrile; l-[6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-l-yl]-2- [3-(trifluoromethyl)-4,5,6,7- tetrahydropyrazolo[4,3-c]pyridin-l-yl]-3-pyridyl]ethanol; l-[6-[6-[(6-methylpyridazin-3-yl)amino]benzimidazol-l-yl]-2- [3-(trifluoromethyl)-4, 5,6,7- tetrahydropyrazolo[4,3-c]pyridin-l-yl]-3-pyridyl]ethanol; l-[3-(l-hydroxyethyl)-6-[5-[(5-methyl-l,3,4-oxadiazol-2-yl)a mino]benzimidazol-l-yl]-2- pyridyl]-5-methyl-pyrazole-3-carbonitrile;

2-[3-(l-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino ]benzimidazol-l-yl]-2-pyridyl]-5- methyl-pyrazole-3 -carbonitrile; (3R)- 1 -[3 -(1 -hydroxy ethyl)-6-[6-[(6-m ethyl pyridazin-3 -yl)amino]benzimidazol- 1 -yl] -2- pyridyl]pyrrolidine-3-carbonitrile; rac-(3R)-l-[3-(l-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl )amino]benzimidazol-l-yl]-2- pyridyl]pyrrolidine-3-carbonitrile; l-[2-(3,5-dimethylpyrazol-l-yl)-6-[6-[(6-methylpyridazin-3-y l)amino]benzimidazol-l-yl]-3- pyridyl] ethanol; l-[2-(3,5-dimethylpyrazol-l-yl)-6-[5-[(6-methylpyridazin-3-y l)amino]benzimidazol-l-yl]-3- pyridyl] ethanol;

5-methyl-l-[6-[5-[(6-methylpyridazin-3-yl)amino]benzimida zol-l-yl]-3-[rac-(lR)-l- hydroxyethyl]-2-pyridyl]pyrazole-3-carbonitrile;

5-methyl-l-[6-[5-[(6-methylpyridazin-3-yl)amino]benzimida zol-l-yl]-3-[rac-(lS)-l- hydroxyethyl]-2-pyridyl]pyrazole-3-carbonitrile; l-[3-(l-hydroxyethyl)-6-[5-[(5-methyl-l,3,4-thiadiazol-2-yl) amino]benzimidazol-l-yl]-2- pyridyl]-5-methyl-pyrazole-3-carbonitrile; l-[3-(l-hydroxyethyl)-6-[5-[[l-(oxetan-3-yl)-4-piperidyl]oxy ]benzimidazol-l-yl]-2-pyridyl]-5- methyl-pyrazole-3 -carbonitrile; l-[3-(l-hydroxyethyl)-6-[6-[[l-(oxetan-3-yl)-4-piperidyl]oxy ]benzimidazol-l-yl]-2-pyridyl]-5- methyl-pyrazole-3 -carbonitrile; l-[3-(l-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino]be nzimidazol-l-yl]-2- pyridyl]pyrazole-3-carbonitrile; l-[[[3-(l-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino] benzimidazol-l-yl]-2- pyri dyl ] amino] methyl] cy cl opropanecarb onitril e ; l-[[[3-(l-hydroxyethyl)-6-[6-[(6-methylpyridazin-3-yl)amino] benzimidazol-l-yl]-2- pyridyl]amino]methyl]cyclopropanecarbonitrile;

5-[3-(l-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino ]benzimidazol-l-yl]-2- pyridyl]pyridine-3 -carbonitrile; l-[3-(l-hydroxyethyl)-6-[5-(l,2,4-triazin-3-ylamino)benzimid azol-l-yl]-2-pyridyl]-5-methyl- pyrazole-3 -carbonitrile; l-[3-(l-hydroxyethyl)-6-[6-[(6-methylpyridazin-3-yl)amino]be nzimidazol-l-yl]-2-pyridyl]-3- methyl-pyrrolidine-3-carbonitrile; l-[3-(l-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino]be nzimidazol-l-yl]-2-pyridyl]-3- methyl-pyrrolidine-3-carbonitrile; l-[6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-l-yl]-2- [2-methyl-5- (trifluoromethyl)pyrazol -3 -yl ] -3 -pyri dyl ] ethanol ; l-[3-(l-hydroxyethyl)-6-[5-(isoxazol-3-ylamino)benzimidazol- l-yl]-2-pyridyl]-5-methyl- pyrazole-3 -carbonitrile;

3-(l-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino]be nzimidazol-l-yl]-N-(2,2,2- trifluoroethyl)pyridine-2-carboxamide; l-[6-[6-[(6-methylpyridazin-3-yl)amino]benzimidazol-l-yl]-2- [rac-(3aR,6aS)-2,3,3a,5,6,6a- hexahy dro- 1 H-pyrrolo [ 3 ,2-b ] pyrrol -4-yl ] -3 -pyri dyl ] ethanol ; l-[6-[6-[(6-methylpyridazin-3-yl)amino]benzimidazol-l-yl]-2- [rac-(3aS,6aR)-2,3,3a,5,6,6a- hexahy dro- 1 H-pyrrolo [ 3 ,2-b ] pyrrol -4-yl ] -3 -pyri dyl ] ethanol ; l-[6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-l-yl]-2- [rac-(3aR,6aS)-2,3,3a,5,6,6a- hexahy dro- 1 H-pyrrolo [ 3 ,2-b ] pyrrol -4-yl ] -3 -pyri dyl ] ethanol ; l-[2-[3-(difluoromethyl)-5-methyl-pyrazol-l-yl]-6-[6-[(6-met hylpyridazin-3- yl)amino]benzimidazol-l-yl]-3-pyridyl]ethanol; l-[2-[3-(difluoromethyl)-5-methyl-pyrazol-l-yl]-6-[5-[(6-met hylpyridazin-3- yl)ami no]b enzimi dazol - 1 -yl ] -3 -pyri dyl ] ethanol ; l-[6-[6-bromo-5-[4-(oxetan-3-yl)piperazin-l-yl]benzimidazol- l-yl]-3-(l-hydroxyethyl)-2- pyridyl]-5-methyl-pyrazole-3-carbonitrile; l-[2-(3-ethoxy-5-methyl-pyrazol-l-yl)-6-[5-[(6-methylpyridaz in-3-yl)amino]benzimidazol-l-yl]- 3-pyridyl]ethanol; l-[2-(3-ethoxy-5-methyl-pyrazol-l-yl)-6-[6-[(6-methylpyridaz in-3-yl)amino]benzimidazol-l-yl]-

3-pyridyl]ethanol; l-[2-(6-methylpyridazin-4-yl)-6-[5-[(6-methylpyridazin-3-yl) amino]benzimidazol-l-yl]-3- pyridyl] ethanol;

4-[3-(l-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino ]benzimidazol-l-yl]-2-pyridyl]-l- (2,2,2-trifluoroethyl)piperazin-2-one;

4-[3-(l-hydroxyethyl)-6-[6-[(6-methylpyridazin-3-yl)amino ]benzimidazol-l-yl]-2-pyridyl]-l- (2,2,2-trifluoroethyl)piperazin-2-one; l-[[3-(l-hydroxyethyl)-6-[6-[(6-methylpyridazin-3-yl)amino]b enzimidazol-l-yl]-2- pyri dyl ] oxym ethyl ] cy cl opropanecarb onitril e ; l-[[3-(l-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino]b enzimidazol-l-yl]-2- pyri dyl ] oxym ethyl ] cy cl opropanecarb onitril e ; l-[3-(l-hydroxyethyl)-6-[5-methoxy-6-[(6-methylpyridazin-3-y l)amino]benzimidazol-l-yl]-2- pyridyl]-5-methyl-pyrazole-3-carbonitrile; l-[6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-l-yl]-2- [3-methyl-l -(2,2,2- trifluoroethyl)pyrazol-4-yl]-3-pyridyl]ethanol; l-[3-(l-hydroxyethyl)-6-[6-[(6-methylpyridazin-3-yl)amino]be nzimidazol-l-yl]-2-pyridyl]-N,5- dimethyl-pyrazole-3-carboxamide; l-[2-(5-methyl-3-methylsulfonyl-pyrazol-l-yl)-6-[5-[(6-methy lpyridazin-3- yl)ami no]b enzimi dazol - 1 -yl ] -3 -pyri dyl ] ethanol ;

1 -[3 -(1 -hydroxy ethy l)-6- [ 5 - [(2 -keto- 1 -m ethyl -pyrimidin-4-yl)amino]benzimidazol- 1 -yl] -2- pyridyl]-5-methyl-pyrazole-3-carbonitrile;

5-methyl-l-[6-[5-[(6-methylpyridazin-3-yl)amino]benzimida zol-l-yl]-3-(2,2,2-trifluoro-l- hydroxy-ethyl)-2-pyridyl]pyrazole-3-carbonitrile; l-[2-[l-(difluoromethyl)-3-methyl-pyrazol-4-yl]-6-[5-[(6-met hylpyridazin-3- yl)ami no]b enzimi dazol - 1 -yl ] -3 -pyri dyl ] ethanol ; l-[3-(l-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino]be nzimidazol-l-yl]-2-pyridyl]-5- methyl-pyrazole-4-carbonitrile; l-[3-(l-hydroxyethyl)-6-[6-[(6-methylpyridazin-3-yl)amino]be nzimidazol-l-yl]-2-pyridyl]-5- methyl-pyrazole-4-carbonitrile; l-[3-(l-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino]be nzimidazol-l-yl]-2-pyridyl]-N,5- dimethyl-pyrazole-3-carboxamide; l-[3-(l-hydroxyethyl)-6-[5-[(2-keto-l-methyl-4-piperidyl)ami no]benzimidazol-l-yl]-2-pyridyl]- 5-methyl-pyrazole-3-carbonitrile;

[2-(3-methoxy-5-methyl-pyrazol-l-yl)-6-[5-[(6-methylpyrid azin-3-yl)amino]benzimidazol-l-yl]- 3 -pyri dyl] methanol ; l-[2-(3,5-dimethylisoxazol-4-yl)-6-[5-[(6-methylpyridazin-3- yl)amino]benzimidazol-l-yl]-3- pyri dyl] ethanol; l-[3-(l-hydroxyethyl)-6-[5-[(4-methoxypyridazin-3-yl)amino]b enzimidazol-l-yl]-2-pyridyl]-5- methyl-pyrazole-3 -carbonitrile; l-[3-(l-hydroxyethyl)-6-[5-[(5-keto-l -methyl -pyrrolidin-3-yl)amino]benzimidazol-l -yl]-2- pyridyl]-5-methyl-pyrazole-3-carbonitrile; l-[6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-l-yl]-2- (3-methyl-4-pyridyl)-3- pyri dyl] ethanol; l-[2-[4-(cyclopropylamino)pyrimidin-5-yl]-6-[5-[(6-methylpyr idazin-3-yl)amino]benzimidazol-

1 -yl ] -3 -pyri dyl ] ethanol ;

5-[3-(l-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino ]benzimidazol-l-yl]-2-pyridyl]-4- (trifluoromethyl)pyridin-2-ol;

3-[3-(l-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino ]benzimidazol-l-yl]-2-pyridyl]-6,7- dihydro-5H-pyrazolo[l,5-a]pyrazin-4-one; l-[6-[6-fluoro-5-[[(3S,4R)-4-fluoropyrrolidin-3-yl]amino]ben zimidazol-l-yl]-3-(l- hydroxyethyl)-2-pyridyl]-5-methyl-pyrazole-3-carbonitrile; l-[2-[2-(difluoromethoxy)-5-methyl-4-pyridyl]-6-[5-[(6-methy lpyridazin-3- yl)ami no]b enzimi dazol - 1 -yl ] -3 -pyri dyl ] ethanol ; l-[2-(2-fluoro-5-methyl-4-pyridyl)-6-[5-[(6-methylpyridazin- 3-yl)amino]benzimidazol-l-yl]-3- pyri dyl] ethanol; l-[3-(l-hydroxyethyl)-6-[6-[(6-methylpyridazin-3-yl)amino]be nzimidazol-l-yl]-2-pyridyl]-4- methyl-pyrazole-3 -carbonitrile; l-[3-(l-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino]be nzimidazol-l-yl]-2-pyridyl]-4- methyl-pyrazole-3 -carbonitrile; l-[6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-l-yl]-2- [5-methyl-3-(trifluoromethyl)-6,7- dihydro-4H-pyrazol o [4, 3 -c] pyri din- 1 -yl ] -3 -pyri dyl ] ethanol ; l-[[[3-(l-hydroxyethyl)-6-[6-[(6-methylpyridazin-3-yl)amino] benzimidazol-l-yl]-2-pyridyl]- methyl-amino]methyl]cyclopropanecarbonitrile; l-[[[3-(l-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino] benzimidazol-l-yl]-2-pyridyl]- methyl-amino]methyl]cyclopropanecarbonitrile; l-[2-(2-chloro-5-fluoro-3-pyridyl)-6-[5-[(6-methylpyridazin- 3-yl)amino]benzimidazol-l-yl]-3- pyri dyl] ethanol; l-[3-(l-hydroxyethyl)-6-[6-[[6-[(3-methoxyazetidin-l-yl)meth yl]pyridazin-3- yl]amino]benzimidazol-l-yl]-2-pyridyl]-5-methyl-pyrazole-3-c arbonitrile; l-[3-(l-hydroxyethyl)-6-[5-[[6-[(3-methoxyazetidin-l-yl)meth yl]pyridazin-3- yl]amino]benzimidazol-l-yl]-2-pyridyl]-5-methyl-pyrazole-3-c arbonitrile; l-[6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-l-yl]-2- [5-(oxetan-3-yl)-3- (trifluoromethyl)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-l-yl ]-3-pyridyl]ethanol; l-[3-(l-hydroxyethyl)-6-[6-[(6-methylpyridazin-3-yl)amino]be nzimidazol-l-yl]-2-pyridyl]-3- methyl-pyrazole-4-carbonitrile; l-[2-[2-(methylamino)-3-pyridyl]-6-[5-[(6-methylpyridazin-3- yl)amino]benzimidazol-l-yl]-3- pyri dyl] ethanol; l-[3-(l-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino]be nzimidazol-l-yl]-2-pyridyl]-3- methyl-pyrazole-4-carbonitrile; l-[3-(l-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino]be nzimidazol-l-yl]-2-pyridyl]-3- methyl-azetidine-3 -carbonitrile; l-[3-(l-hydroxyethyl)-6-[6-[(6-methylpyridazin-3-yl)amino]be nzimidazol-l-yl]-2-pyridyl]-3- methyl-azetidine-3 -carbonitrile; l-[3-(l-hydroxyethyl)-6-[6-methoxy-5-[(6-methylpyridazin-3-y l)amino]benzimidazol-l-yl]-2- pyridyl]-5-methyl-pyrazole-3-carbonitrile; l-[6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-l-yl]-2- [2-(lH-pyrazol-4-yl)-3-pyridyl]-3- pyridyl] ethanol; l-[3-(l-hydroxyethyl)-6-[6-(2-methoxyethoxy)-5-[(6-methylpyr idazin-3-yl)amino]benzimidazol- l-yl]-2-pyridyl]-5-methyl-pyrazole-3-carbonitrile; l-[6-[5-fluoro-6-[[rac-(3R,4S)-4-fluoropyrrolidin-3-yl]amino ]benzimidazol-l-yl]-3-(l- hydroxyethyl)pyri din-2 -yl]-5-methylpyrazole-3-carbonitrile; l-[6-[6-[2-(dimethylamino)ethoxy]-5-[(6-methylpyridazin-3-yl )amino]benzimidazol-l-yl]-3-(l- hydroxyethyl)-2-pyridyl]-5-methyl-pyrazole-3-carbonitrile; l-[6-[5-bromo-6-[4-(oxetan-3-yl)piperazino]benzimidazol-l-yl ]-3-(l-hydroxyethyl)-2-pyridyl]- 5-methyl-pyrazole-3-carbonitrile; l-[3-(l-hydroxyethyl)-6-[5-[[6-(3-methoxyazetidine-l-carbony l)pyridazin-3- yl]amino]benzimidazol-l-yl]-2-pyridyl]-5-methyl-pyrazole-3-c arbonitrile; l-[3-(l-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino]-6 -pyrrolidin-3-yloxy-benzimidazol- l-yl]-2-pyridyl]-5-methyl-pyrazole-3-carbonitrile; l-[3-(l-hydroxyethyl)-6-[5-[[6-(2-methoxyethoxy)pyridazin-3- yl]amino]benzimidazol-l-yl]-2- pyridyl]-5-methyl-pyrazole-3-carbonitrile; l-[2-(lH-benzotriazol-4-yl)-6-[5-[(6-methylpyridazin-3-yl)am ino]benzimidazol-l-yl]-3- pyridyl] ethanol; l-[6-[5-[[6-(2,2-difluoroethoxy)pyridazin-3-yl]amino]benzimi dazol-l-yl]-3-(l-hydroxyethyl)-2- pyridyl]-5-methyl-pyrazole-3-carbonitrile; l-[6-[5-[[6-(difluoromethoxy)pyridazin-3-yl]amino]benzimidaz ol-l-yl]-3-(l-hydroxyethyl)-2- pyridyl]-5-methyl-pyrazole-3-carbonitrile; l-[3-(2,2-difluoro-l-hydroxy-ethyl)-6-[5-[(6-methylpyridazin -3-yl)amino]benzimidazol-l-yl]-2- pyridyl]-5-methyl-pyrazole-3-carbonitrile;

1 -[3 -(2,2-difluoro- 1 -hy droxy-ethyl)-6-[6-[(6-m ethyl pyridazin-3 -yl)amino]benzimidazol- 1 -yl] -2- pyridyl]-5-methyl-pyrazole-3-carbonitrile;

1 -[6-[6-[( 1 , 1 -di oxo- 1 ,2-thiazolidin-2-yl)methyl]benzimidazol- 1 -yl] -3 -( 1 -hydroxyethyl)-2- pyridyl]-5-methyl-pyrazole-3-carbonitrile;

1 -[6-[5-[(l,l -dioxo- 1,2-thi azolidin-2-yl)methyl]benzimidazol-l -yl]-3-(l -hydroxyethyl)-2- pyridyl]-5-methyl-pyrazole-3-carbonitrile;

3-[3-(l-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino ]benzimidazol-l-yl]-2-pyridyl]-2- methoxy-phenol ;

3-[3-(l-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino ]benzimidazol-l-yl]-2-pyridyl]furan-

2-carbonitrile; l-[3-(l-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino]be nzimidazol-l-yl]pyri din-2 -yl]- 4,5,6,7-tetrahydropyrazolo[4,3-c]pyridine-3-carbonitrile; l-[6-[5-[[6-[2-(l,l-diketo-l,4-thiazinan-4-yl)ethoxy]pyridaz in-3-yl]amino]benzimidazol-l-yl]-3- (l-hydroxyethyl)-2-pyridyl]-5-methyl-pyrazole-3-carbonitrile ; l-[3-(l-hydroxyethyl)-6-[5-[[6-(oxetan-3-yloxy)pyridazin-3-y l]amino]benzimidazol-l-yl]-2- pyridyl]-5-methyl-pyrazole-3-carbonitrile; l-[6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-l-yl]-2- [(3S)-pyrrolidin-3-yl]oxy-3- pyridyl] ethanol; l-[3-(l-hydroxyethyl)-6-[6-[(2-oxopyrrolidin-l-yl)methyl]ben zimidazol-l-yl]-2-pyridyl]-5- methyl-pyrazole-3 -carbonitrile; l-[3-(l-hydroxyethyl)-6-[5-[(2-oxopyrrolidin-l-yl)methyl]ben zimidazol-l-yl]-2-pyridyl]-5- methyl-pyrazole-3 -carbonitrile; l-[2-(3-methoxy-5-methyl-pyrazol-l-yl)-6-[5-[(6-methylpyrida zin-3-yl)amino]benzimidazol-l- yl]-3-pyridyl]ethanol; l-[3-(l-hydroxyethyl)-6-[6-[(2-oxo-l-piperidyl)methyl]benzim idazol-l-yl]-2-pyridyl]-5-methyl- pyrazole-3 -carbonitrile;

1-[3-(l-hydroxyethyl)-6-[5-[(2-oxo-l-piperidyl)methyl]ben zimidazol-l-yl]-2-pyridyl]-5-methyl- pyrazole-3 -carbonitrile;

3-[[l-[6-(3-cyano-5-methyl-pyrazol-l-yl)-5-(l-hydroxyethy l)-2-pyridyl]benzimidazol-5- yl]amino]-N,N,6-trimethyl-pyridazine-4-carboxamide;

5-hydroxy-2-[3-(l-hydroxyethyl)-6-[5-[(6-methylpyridazin- 3-yl)amino]benzimidazol-l-yl]-2- pyridyl]benzonitrile;

5-[3-(l-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino ]benzimidazol-l-yl]-2-pyridyl]-3- (trifluoromethyl)-lH-pyridazin-6-one;

2-[3-(l-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino ]benzimidazol-l-yl]-2-pyridyl]furan-

3 -carbonitrile; l-[2-[2-(2,2-difluorocyclopropyl)pyrazol-3-yl]-6-[5-[(6-meth ylpyridazin-3- yl)ami no]b enzimi dazol - 1 -yl ] -3 -pyri dyl ] ethanol ; l-[3-(l-hydroxyethyl)-6-[5-[[6-(oxetan-3-yl)pyridazin-3-yl]a mino]benzimidazol-l-yl]-2- pyridyl]-5-methyl-pyrazole-3-carbonitrile;

(lS)-l-[2-[3-(difluoromethyl)-5-methyl-pyrazol-l-yl]-6-[5 -[(6-methylpyridazin-3- yl)ami no]b enzimi dazol - 1 -yl ] -3 -pyri dyl ] ethanol ;

(lR)-l-[2-[3-(difluoromethyl)-5-methyl-pyrazol-l-yl]-6-[5 -[(6-methylpyridazin-3- yl)ami no]b enzimi dazol - 1 -yl ] -3 -pyri dyl ] ethanol ; l-[2-[5-(difluoromethyl)-3-methyl-pyrazol-l-yl]-6-[5-[(6-met hylpyridazin-3- yl)ami no]b enzimi dazol - 1 -yl ] -3 -pyri dyl ] ethanol ; l-[3-(l-hydroxy-2-methoxy-ethyl)-6-[5-[(6-methylpyridazin-3- yl)amino]benzimidazol-l-yl]-2- pyridyl]-5-methyl-pyrazole-3-carbonitrile; l-[3-(l-hydroxy-2-methoxy-ethyl)-6-[6-[(6-methylpyridazin-3- yl)amino]benzimidazol-l-yl]-2- pyridyl]-5-methyl-pyrazole-3-carbonitrile; l-[6-[6-fluoro-5-[(6-methylpyridazin-3-yl)amino]benzimidazol -l-yl]-3-[(lS)-l-hydroxyethyl]-2- pyridyl]-5-methyl-pyrazole-3-carbonitrile; l-[6-[6-fluoro-5-[(6-methylpyridazin-3-yl)amino]benzimidazol -l-yl]-3-[(lR)-l-hydroxyethyl]-2- pyridyl]-5-methyl-pyrazole-3-carbonitrile; l-[5-chloro-3-(l-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl )amino]benzimidazol-l-yl]-2- pyridyl]pyrazole-3-carbonitrile; l-[6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-l-yl]-2- [5-methyl-l -(2,2,2- trifluoroethyl)pyrazol-4-yl]-3-pyridyl]ethanol; l-[6-[5-[(6-chloro-4-methoxy-pyridazin-3-yl)amino]benzimidaz ol-l-yl]-3-(l-hydroxyethyl)-2- pyridyl]-5-methyl-pyrazole-3-carbonitrile; rac-(3R,5S)-l-[3-(l-hydroxyethyl)-6-[5-[(6-methylpyridazin-3 -yl)amino]benzimidazol-l-yl]-2- pyridyl]-5-methyl-pyrrolidine-3-carbonitrile; l-[5-chloro-3-(l-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl )amino]benzimidazol-l-yl]-2- pyridyl]-5-methyl-pyrazole-3-carbonitrile;

5-[3-(l-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino ]benzimidazol-l-yl]-2-pyridyl]-2- methyl-pyrazole-3 -carbonitrile; l-[3-[(lR)-l-hydroxyethyl]-6-[6-[(6-methylpyridazin-3-yl)ami no]benzimidazol-l-yl]-2-pyridyl]- 5-methyl-pyrazole-3-carbonitrile; l-[2-[3,5-bis(difluoromethyl)pyrazol-l-yl]-6-[5-[(6-methylpy ridazin-3-yl)amino]benzimidazol-

1 ^_ yl ] Pyri din-3 -yl ] ethanol ; l-[3-(l-hydroxyethyl)-6-[5-[[6-(trifluoromethyl)pyridazin-3- yl]amino]benzimidazol-l-yl]-2- pyridyl]-5-methyl-pyrazole-3-carbonitrile; l-[2-[2-ethyl-5-(trifluoromethyl)pyrazol-3-yl]-6-[5-[(6-meth ylpyridazin-3- yl)ami no]b enzimi dazol - 1 -yl ] -3 -pyri dyl ] ethanol ; rac-(lS)-l-[6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol -l-yl]-2-[3-methyl-l -(2,2,2- trifluoroethyl)pyrazol-4-yl]-3-pyridyl]ethanol; rac-(lR)- l-[6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-l-yl]-2- [3-methyl-l -(2,2,2- trifluoroethyl)pyrazol-4-yl]-3-pyridyl]ethanol;

1-[3-(l-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino ]benzimidazol-l-yl]-2- pyridyl]triazole-4-carbonitrile;

(3S,5R)-l-[3-(l-hydroxyethyl)-6-[5-[(6-methylpyridazin-3- yl)amino]benzimidazol-l-yl]-2- pyridyl]-5-methyl-pyrrolidine-3-carbonitrile;

5-[3-(l-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino ]benzimidazol-l-yl]-2-pyridyl]-l- methyl-pyrazole-3 -carbonitrile;

2-[3-(l-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino ]benzimidazol-l-yl]-2- pyridyl]triazole-4-carbonitrile; l-[6-(3-cyano-5-methylpyrazol-l-yl)-5-(l-hydroxyethyl)pyridi n-2-yl]benzimidazole-5- carbonitrile; l-[2-(l-ethyl-3-methyl-pyrazol-4-yl)-6-[5-[(6-methylpyridazi n-3-yl)amino]benzimidazol-l-yl]-3- pyri dyl] ethanol; l-[2-[l-(2-methoxyethyl)-3-methyl-pyrazol-4-yl]-6-[5-[(6-met hylpyridazin-3- yl)ami no]b enzimi dazol - 1 -yl ] -3 -pyri dyl ] ethanol ; l-[2-[l-(cyclopropylmethyl)-3-methyl-pyrazol-4-yl]-6-[5-[(6- methylpyridazin-3- yl)ami no]b enzimi dazol - 1 -yl ] -3 -pyri dyl ] ethanol ;

5-methyl-l-[3-methylol-6-[6-[(6-methylpyridazin-3-yl)amin o]benzimidazol-l-yl]-2- pyridyl]pyrazole-3-carbonitrile;

5-methyl-l-[3-methylol-6-[5-[(6-methylpyridazin-3-yl)amin o]benzimidazol-l-yl]-2- pyridyl]pyrazole-3-carbonitrile; l-[2-(l-ethyl-5-methyl-pyrazol-4-yl)-6-[5-[(6-methylpyridazi n-3-yl)amino]benzimidazol-l-yl]-3- pyridyl] ethanol; l-[2-[l-(cyclopropylmethyl)-5-methyl-pyrazol-4-yl]-6-[5-[(6- methylpyridazin-3- yl)ami no]b enzimi dazol - 1 -yl ] -3 -pyri dyl ] ethanol ; l-[2-[l-(cyclobutylmethyl)-3-methyl-pyrazol-4-yl]-6-[5-[(6-m ethylpyridazin-3- yl)ami no]b enzimi dazol - 1 -yl ] -3 -pyri dyl ] ethanol ; l-[2-[l-(cyclobutylmethyl)-5-methyl-pyrazol-4-yl]-6-[5-[(6-m ethylpyridazin-3- yl)ami no]b enzimi dazol - 1 -yl ] -3 -pyri dyl ] ethanol ; l-[3-(l-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino]-6 -(trifluoromethyl)benzimidazol-l- yl]-2-pyridyl]-5-methyl-pyrazole-3-carbonitrile; l-[3-[(lS)-l-hydroxyethyl]-6-[5-[(6-methylpyridazin-3-yl)ami no]benzimidazol-l-yl]-2-pyridyl]- 5-methyl-pyrazole-3-carboximidic acid methyl ester; l-[2-[l-(2,2-difluorocyclopropyl)-3-methyl-pyrazol-4-yl]-6-[ 5-[(6-methylpyridazin-3- yl)ami no]b enzimi dazol - 1 -yl ] -3 -pyri dyl ] ethanol ; l-[2-[l-(2-methoxypropyl)-3-methyl-pyrazol-4-yl]-6-[5-[(6-me thylpyridazin-3- yl)ami no]b enzimi dazol - 1 -yl ] -3 -pyri dyl ] ethanol ; l-[2-[l-(2-methoxypropyl)-5-methyl-pyrazol-4-yl]-6-[5-[(6-me thylpyridazin-3- yl)amino]benzimidazol-l-yl]-3-pyridyl]ethanol; l-[3-[(lS)-l-hydroxyethyl]-6-[6-[(6-methylpyridazin-3-yl)ami no]benzimidazol-l-yl]-2-pyridyl]- 5-methyl-pyrazole-3-carbonitrile; l-[2-[l-(2,2-difluoropropyl)-3-methyl-pyrazol-4-yl]-6-[5-[(6 -methylpyridazin-3- yl)ami no]b enzimi dazol - 1 -yl ] -3 -pyri dyl ] ethanol ; l-[3-(l-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino]-6 -(oxetan-3-yloxy)benzimidazol-l- yl]-2-pyridyl]-5-methyl-pyrazole-3-carbonitrile; l-[2-(2-ethyl-5-methyl-4-pyridyl)-6-[5-[(6-methylpyridazin-3 -yl)amino]benzimidazol-l-yl]-3- pyri dyl] ethanol; l-[2-[l-(2,2-difluoropropyl)-5-methyl-pyrazol-4-yl]-6-[5-[(6 -methylpyridazin-3- yl)ami no]b enzimi dazol - 1 -yl ] -3 -pyri dyl ] ethanol ; l-[2-(2-methoxy-5-methyl-4-pyridyl)-6-[5-[(6-methylpyridazin -3-yl)amino]benzimidazol-l-yl]- 3-pyridyl]ethanol;

(lS)-l-[2-[3,5-bis(difluoromethyl)pyrazol-l-yl]-6-[5-[(6- methylpyridazin-3- yl)ami no]b enzimi dazol - 1 -yl ] -3 -pyri dyl ] ethanol ;

(lR)-l-[2-[3,5-bis(difluoromethyl)pyrazol-l-yl]-6-[5-[(6- methylpyridazin-3- yl)ami no]b enzimi dazol - 1 -yl ] -3 -pyri dyl ] ethanol ; l-[2-(2-cyclopropyl-5-methyl-4-pyridyl)-6-[5-[(6-methylpyrid azin-3-yl)amino]benzimidazol-l- yl]-3-pyridyl]ethanol; l-[2-[3-(difluoromethoxy)-5-methyl-pyrazol-l-yl]-6-[5-[(6-me thylpyridazin-3- yl)ami no]b enzimi dazol - 1 -yl ] -3 -pyri dyl ] ethanol ; l-[3-(l-hydroxyethyl)-6-[6-[(6-methylpyridazin-3-yl)amino]be nzimidazol-l-yl]-2-pyridyl]-5- methyl-6,7-dihydro-4~{H}-pyrazolo[4,3-c]pyridine-3-carbonitr ile; l-[3-(l-hydroxyethyl)-6-[5-[(6-methyl-4-methylsulfonyl-pyrid azin-3-yl)amino]benzimidazol-l- yl]-2-pyridyl]-5-methyl-pyrazole-3-carbonitrile; l-[3-(l-hydroxyethyl)-6-[5-[[6-[2-[2-[2-[2-[2-[2-(2- m ethoxy ethoxy)ethoxy] ethoxy] ethoxy] ethoxy] ethoxy]ethoxy]pyridazin-3 - yl]amino]benzimidazol-l-yl]-2-pyridyl]-5-methyl-pyrazole-3-c arbonitrile; l-[3-(l-hydroxyethyl)-6-[6-[(6-methyl-3-pyridyl)amino]-5-(2- morpholinoethoxy)benzimidazol- l-yl]-2-pyridyl]-5-methyl-pyrazole-3-carbonitrile; l-[3-(l-hydroxyethyl)-6-[6-(2-oxa-5-azaspiro[3.4]octan-5-yl) benzimidazol-l-yl]-2-pyridyl]-5- methyl-pyrazole-3 -carbonitrile; l-[3-(l-hydroxyethyl)-6-[5-(2-oxa-5-azaspiro[3.4]octan-5-yl) benzimidazol-l-yl]-2-pyridyl]-5- methyl-pyrazole-3 -carbonitrile; l-[3-(l-hydroxyethyl)-6-[5-[(6-methyl-3-pyridyl)amino]-6-(2- morpholinoethoxy)benzimidazol- l-yl]-2-pyridyl]-5-methyl-pyrazole-3-carbonitrile; l-[2-[3-(difluoromethyl)pyrrolidin-l-yl]-6-[5-[(6-methylpyri dazin-3-yl)amino]benzimidazol-l- yl]-3-pyridyl]ethanol; l-[2-(2,2-difluoro-5-azaspiro[2.4]heptan-5-yl)-6-[5-[(6-meth ylpyridazin-3- yl)ami no]b enzimi dazol - 1 -yl ] -3 -pyri dyl ] ethanol ;

(lS)-l-[2-[3-(difluoromethyl)-5-methyl-pyrazol-l-yl]-6-[6 -fluoro-5-[(6-methylpyridazin-3- yl)ami no]b enzimi dazol - 1 -yl ] -3 -pyri dyl ] ethanol ; l-[6-[6-fluoro-5-[(6-methylpyridazin-3-yl)amino]benzimidazol -l-yl]-2-[3-methyl-l -(2,2,2- trifluoroethyl)pyrazol-4-yl]-3-pyridyl]ethanol;

5-(difluoromethyl)-2-[3-(l-hydroxyethyl)-6-[5-[(6-methylp yridazin-3-yl)amino]benzimidazol-l- yl]-2-pyridyl]pyrazole-3-carbonitrile; l-[3-(l-hydroxyethyl)-6-[5-[[6-[l-(oxetan-3-yl)pyrrolidin-2- yl]pyridazin-3- yl]amino]benzimidazol-l-yl]-2-pyridyl]-5-methyl-pyrazole-3-c arbonitrile;

7,7-difluoro-l-[3-(l-hydroxyethyl)-6-[5-[(6-methylpyridaz in-3-yl)amino]benzimidazol-l-yl]-2- pyridyl]-5,6-dihydro-4~{H}-pyrazolo[4,3-c]pyridine-3-carboni trile;

5-(difluoromethyl)-l-[3-(l-hydroxyethyl)-6-[5-[(6-methylp yridazin-3-yl)amino]benzimidazol-l- yl]-2-pyridyl]pyrazole-3-carbonitrile;

(lS)-l-[2-[3-(difluoromethyl)-5-methyl-pyrazol-l-yl]-6-[6 -fluoro-5-(pyridazin-3- yl amino)b enzimi dazol - 1 -yl ] -3 -pyri dyl ] ethanol ; l-[6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-l-yl]-2- [5-methyl-2-(2,2,2- trifluoroethyl)tri azol -4-yl ] -3 -pyri dyl ] ethanol ; l-[3-(l-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino]be nzimidazol-l-yl]-2-pyridyl]-4,5- dimethyl-pyrazole-3-carbonitrile; l-[3-(l-hydroxyethyl)-6-[5-[(4-methyl-2,3-dihydropyridazino[ 4,5-b][l,4]oxazin-8- yl)amino]benzimidazol-l-yl]-2-pyridyl]-5-methyl-pyrazole-3-c arbonitrile; l-[6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-l-yl]-2- [5-methyl-l -(2,2,2- trifluoroethyl)tri azol -4-yl] -3 -pyri dyl ] ethanol ; 1 ■[ 1 -[6-(3-cyano-5-methyl-pyrazol- 1 -yl)-5 -( 1 -hydroxyethyl)-2-pyridyl]benzimidazol-5-yl]-N,N- dimethyl-pyrrolidine-2-carboxamide; l-[2-[l-(2,2-difluoroethyl)-3-methyl-pyrazol-4-yl]-6-[5-[(6- methylpyridazin-3- yl)ami no]b enzimi dazol - 1 -yl ] -3 -pyri dyl ] ethanol ; l-[6-[5-fluoro-6-[(6-methylpyridazin-3-yl)amino]benzimidazol -l-yl]-3-(hydroxymethyl)-2- pyridyl]-5-methyl-pyrazole-3-carbonitrile;

[6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-l -yl]-2-[3-methyl-l -(2,2,2- trifluoroethyl)pyrazol-4-yl]-3-pyridyl]methanol;

[6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-l -yl]-2-[5-methyl-l -(2,2,2- trifluoroethyl)pyrazol-4-yl]-3-pyridyl]methanol;

[2-[3-(difluoromethyl)-5-methyl-pyrazol-l-yl]-6-[5-(7,8-d ihydro-5H-pyrano[4,3-c]pyridazin-3- yl amino)b enzimi dazol - 1 -yl ] -3 -pyri dyl ] methanol ;

[6-[5-[(4aS,7aR)-4-methyl-2,3,4a,5,7,7a-hexahydropyrrolo[ 3,4-b][l,4]oxazin-6-yl]benzimidazol- l-yl]-2-[3-(difluoromethyl)-5-methyl-pyrazol-l-yl]-3-pyridyl ]methanol;

[2-[3-(difluoromethyl)-5-methyl-pyrazol-l-yl]-6-[6-fluoro -5-[(6-methylpyridazin-3- yl)amino]benzimidazol-l-yl]-3-pyridyl]methanol; l-[6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-l-yl]-2- [2-(trifluoromethyl)morpholin-4- yl]-3-pyridyl]ethanol;

3-[3-(l-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino ]benzimidazol-l-yl]-2-pyridyl]-3- azabicyclo[3.1 ,0]hexane- 1 -carbonitrile; l-[2-(5,5-difluoro-2-azabicyclo[2.2.1]heptan-2-yl)-6-[5-[(6- methylpyridazin-3- yl)ami no]b enzimi dazol - 1 -yl ] -3 -pyri dyl ] ethanol ; l-[2-[2-(difluoromethyl)morpholin-4-yl]-6-[5-[(6-methylpyrid azin-3-yl)amino]benzimidazol-l- yl]-3-pyridyl]ethanol; l-[2-(6,6-difluoro-2-azabicyclo[2.2.1]heptan-2-yl)-6-[5-[(6- methylpyridazin-3- yl)ami no]b enzimi dazol - 1 -yl ] -3 -pyri dyl ] ethanol ; l-[2-[7-(difluoromethyl)-5-azaspiro[2.4]heptan-5-yl]-6-[5-[( 6-methylpyridazin-3- yl)ami no]b enzimi dazol - 1 -yl ] -3 -pyri dyl ] ethanol ; l-[2-(6,6-difluoro-3-azabicyclo[3.2.0]heptan-3-yl)-6-[5-[(6- methylpyridazin-3- yl)ami no]b enzimi dazol - 1 -yl ] -3 -pyri dyl ] ethanol ;

N-[l-[6-(3-cyano-5-methyl-pyrazol-l-yl)-5-(l-hydroxyethyl )-2-pyridyl]benzimidazol-5- yl]cyclopropanecarboxamide;

N-[3-[6-(3-cyano-5-methyl-pyrazol-l-yl)-5-(l-hydroxyethyl )-2-pyridyl]benzimidazol-5- yl]cyclopropanecarboxamide; l-[2-(4,7-diazaspiro[2.5]octan-7-yl)-6-[5-[(6-methylpyridazi n-3-yl)amino]benzimidazol-l-yl]-3- pyri dyl] ethanol; l-[6-[5-[(3aS,6aS)-6-oxo-2,3,3a,4,5,6a-hexahydropyrrolo[2,3- c]pyrrol-l-yl]benzimidazol-l-yl]- 3-(l-hydroxyethyl)-2-pyridyl]-5-methyl-pyrazole-3-carbonitri le; l-[6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-l-yl]-2- [3-(trifluoromethyl)piperazin-l- yl]-3-pyridyl]ethanol; l-[6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-l-yl]-2- [5-methyl-2-(trifluoromethyl)-4- pyri dyl ] - 3 -pyri dyl ] ethanol ; l-[3-(l-hydroxyethyl)-6-[5-[(2-keto-l-methyl-3-pyridyl)amino ]benzimidazol-l-yl]-2-pyridyl]-5- methyl-pyrazole-3 -carbonitrile;

1 -[3-(l -hydroxyethyl)-6-[5-(3-methoxy-l -methyl -pyrazol -4-yl)benzimidazol-l -yl]-2-pyridyl]-5- methyl-pyrazole-3 -carbonitrile; l-[2-[2-(difluoromethyl)-5-methyl-4-pyridyl]-6-[5-[(6-methyl pyridazin-3- yl)ami no]b enzimi dazol - 1 -yl ] -3 -pyri dyl ] ethanol ; l-[3-(l-hydroxyethyl)-6-[6-(l -methyl -2-oxo-pyrimidin-4-yl)benzimidazol-l -yl]-2-pyridyl]-5- methyl-pyrazole-3 -carbonitrile; l-[2-[3-(difluoromethyl)-5-methyl-pyrazol-l-yl]-6-[6-fluoro- 5-[[6-(2-methyl-l,3-dioxolan-2- yl)pyridazin-3-yl]amino]benzimidazol-l-yl]-3-pyridyl]ethanol ; l-[3-(l-hydroxyethyl)-6-[5-(l -methyl -2-oxo-pyrimidin-4-yl)benzimidazol-l -yl]-2-pyridyl]-5- methyl-pyrazole-3 -carbonitrile; l-[3-(l-hydroxyethyl)-6-[6-(6-methylpyridazin-3-yl)benzimida zol-l-yl]-2-pyridyl]-5-methyl- pyrazole-3 -carbonitrile; l-[3-(l-hydroxyethyl)-6-[5-(6-methylpyridazin-3-yl)benzimida zol-l-yl]-2-pyridyl]-5-methyl- pyrazole-3 -carbonitrile; l-[6-[6-[(2S)-2-cyanopyrrolidin-l-yl]benzimidazol-l-yl]-3-(l -hydroxyethyl)-2-pyridyl]-5- methyl-pyrazole-3 -carbonitrile; l-[6-[5-[(2S)-2-cyanopyrrolidin-l-yl]benzimidazol-l-yl]-3-(l -hydroxyethyl)-2-pyridyl]-5- methyl-pyrazole-3 -carbonitrile; l-[6-[6-[(3aS,6aS)-6-oxo-2,3,3a,4,5,6a-hexahydropyrrolo[2,3- c]pyrrol-l-yl]benzimidazol-l-yl]- 3-(l-hydroxyethyl)-2-pyridyl]-5-methyl-pyrazole-3-carbonitri le; l-[2-[3-(difluoromethyl)-5-methyl- 1,2, 4-tri azol- 1 -yl]-6-[5-[(6-methylpyridazin-3- yl)ami no]b enzimi dazol - 1 -yl ] -3 -pyri dyl ] ethanol ;

3-[[l-[6-[3-(difluoromethyl)-5-methyl-pyrazol-l-yl]-5-[(l ~{S})-l-hydroxyethyl]-2-pyridyl]-6- fluoro-benzimidazol-5-yl]amino]-~{N},~{N},6-trimethyl-pyrida zine-4-carboxamide; l-[2-[2-(difluoromethoxy)-5-methyl-4-pyridyl]-6-[6-fluoro-5- [(6-methylpyridazin-3- yl)amino]benzimidazol-l-yl]-3-pyridyl]ethanol; l-[6-[6-fluoro-5-[(6-methylpyridazin-3-yl)amino]benzimidazol -l-yl]-3-(hydroxymethyl)-2- pyridyl]-5-methyl-pyrazole-3-carbonitrile;

3-[[l-[6-[3,5-bis(difluoromethyl)pyrazol-l-yl]-5-(hydroxy methyl)-2-pyridyl]benzimidazol-5- yl]amino]-N,N,6-trimethyl-pyridazine-4-carboxamide; l-[6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-l-yl]-2- [4-methyl-l -(2,2,2- trifluoroethyl)pyrazol -3 -yl ] -3 -pyri dyl ] ethanol ; l-[2-[3-methyl-l-(2,2,2-trifluoroethyl)pyrazol-4-yl]-6-[5-[6 -(morpholinomethyl)pyridazin-3- yl ] oxyb enzimi dazol - 1 -yl] -3 -pyri dyl ] ethanol ; l-[6-[5-(6-methylpyridazin-3-yl)oxybenzimidazol-l-yl]-2-[3-m ethyl-l -(2,2,2- trifluoroethyl)pyrazol-4-yl]-3-pyridyl]ethanol; l-[6-[5-[6-[(4-methylpiperazin-l-yl)methyl]pyridazin-3-yl]ox ybenzimidazol-l-yl]-2-[3-methyl- l-(2,2,2-trifluoroethyl)pyrazol-4-yl]-3-pyridyl]ethanol; l-[2-[3-(difluoromethoxy)-5-methyl-pyrazol-l-yl]-6-[6-[(6-me thylpyridazin-3-yl)amino]-5-

(ox etan-3 -yl oxy)b enzimi dazol - 1 -yl ] -3 -pyri dyl ] ethanol ; l-[2-(3-chloro-5-methyl-pyrazol-l-yl)-6-[5-fluoro-6-[(6-meth ylpyridazin-3- yl)ami no]b enzimi dazol - 1 -yl ] -3 -pyri dyl ] ethanol ; l-[2-(3-chloro-5-methyl-pyrazol-l-yl)-6-[6-fluoro-5-[(6-meth ylpyridazin-3- yl)ami no]b enzimi dazol - 1 -yl ] -3 -pyri dyl ] ethanol ; l-[2-[l-(cyclopropylmethyl)-3-methyl-pyrazol-4-yl]-6-[6-fluo ro-5-[(6-methylpyridazin-3- yl)ami no]b enzimi dazol - 1 -yl ] -3 -pyri dyl ] ethanol ; l-[2-[3-(difluoromethoxy)-5-methyl-pyrazol-l-yl]-6-[5-[(6-me thylpyridazin-3-yl)amino]-6- (ox etan-3 -yl oxy)b enzimi dazol - 1 -yl ] -3 -pyri dyl ] ethanol ;

N-[ 1 - [5 -( 1 -hydroxyethyl)-6-[3 -methyl- 1 -(2,2,2-trifluoroethyl)pyrazol-4-yl]-2- pyridyl]benzimidazol-5-yl]-2-(l-piperidyl)acetamide;

6-[3-(l-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino ]benzimidazol-l-yl]-2-pyridyl]-6- azaspiro[3.4]octane-8-carbonitrile;

4-[3-(l-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino ]benzimidazol-l-yl]-2- pyridyl]morpholine-2-carbonitrile;

N-[l-[6-[3-(difluoromethyl)-5-methyl-pyrazol-l-yl]-5-(l-h ydroxyethyl)-2-pyridyl]-6-fluoro- benzimidazol-5-yl]cyclopropanecarboxamide; l-[6-[6-(2,3-difluoro-4-methyl-anilino)-5-fluoro-benzimidazo l-l-yl]-2-[3-(difluoromethyl)-5- m ethyl -pyrazol - 1 -yl] -3 -pyri dyl ] ethanol ; l-[2-[l-(difluoromethyl)-4-methyl-pyrazol-3-yl]-6-[5-[(6-met hylpyridazin-3- yl)ami no]b enzimi dazol - 1 -yl ] -3 -pyri dyl ] ethanol ; l-[2-[3-(difluoromethyl)-5-methyl-pyrazol-l-yl]-6-[5-fluoro- 6-(2,3,4- trifluoroanilino)benzimidazol-l-yl]-3-pyridyl]ethanol;

1-[3-(l-hydroxyethyl)-6-[6-(6-methyl-7-oxo-5H-pyrrolo[3,4 -b]pyri din-2 -yl)benzimidazol-l-yl]-

2-pyridyl]-5-methyl-pyrazole-3-carbonitrile;

1-[3-(l-hydroxyethyl)-6-[5-(6-methyl-7-oxo-5H-pyrrolo[3,4 -b]pyri din-2 -yl)benzimidazol-l-yl]-

2-pyridyl]-5-methyl-pyrazole-3-carbonitrile; l-[2-[3-(difluoromethoxy)-5-methylpyrazol-l-yl]-6-[5-[[6-(di fluoromethyl)pyridazin-3- yl]amino]benzimidazol-l-yl]pyridin-3-yl]ethanol; l-[2-[3-(difluoromethyl)-5-ethyl-pyrazol-l-yl]-6-[6-[(6-meth ylpyridazin-3- yl)ami no]b enzimi dazol - 1 -yl ] -3 -pyri dyl ] ethanol ; l-[2-[3-(difluoromethyl)-4,5-dimethyl-pyrazol-l-yl]-6-[5-[(6 -methylpyridazin-3- yl)ami no]b enzimi dazol - 1 -yl ] -3 -pyri dyl ] ethanol ; l-[2-[3-(difluoromethyl)-5-ethyl-pyrazol-l-yl]-6-[5-[(6-meth ylpyridazin-3- yl)ami no]b enzimi dazol - 1 -yl ] -3 -pyri dyl ] ethanol ; l-[6-[6-[(6-chloropyridazin-3-yl)amino]-5-fluoro-benzimidazo l-l-yl]-2-[3-(difluoromethyl)-5- m ethyl -pyrazol - 1 -yl] -3 -pyri dyl ] ethanol ; l-[6-[5-[(6-chloropyridazin-3-yl)amino]-6-fluoro-benzimidazo l-l-yl]-2-[3-(difluoromethyl)-5- m ethyl -pyrazol - 1 -yl] -3 -pyri dyl ] ethanol ;

(lS)-l-[2-[3-(difluoromethoxy)-5-methyl-pyrazol-l-yl]-6-[ 6-fluoro-5-(pyridazin-3- yl amino)b enzimi dazol - 1 -yl ] -3 -pyri dyl ] ethanol ;

(lS)-l-[2-[3-(difluoromethoxy)-5-methyl-pyrazol-l-yl]-6-[ 6-fluoro-5-[(6-methylpyridazin-3- yl)ami no]b enzimi dazol - 1 -yl ] -3 -pyri dyl ] ethanol ;

(lR)-l-[2-[3-(difluoromethoxy)-5-methyl-pyrazol-l-yl]-6-[ 6-fluoro-5-[(6-methylpyridazin-3- yl)ami no]b enzimi dazol - 1 -yl ] -3 -pyri dyl ] ethanol ;

1-[6-[5-fluoro-6-[(5-methyl-l, 3, 4-oxadiazol -2 -yl)amino]benzimidazol-l-yl]-3-(l -hydroxyethyl)-

2-pyridyl]-5-methyl-pyrazole-3-carbonitrile; 1-[6-[6-fluoro-5-[(5-methyl-l, 3, 4-oxadiazol -2 -yl)amino]benzimidazol-l-yl]-3-(l -hydroxyethyl)-

2-pyridyl]-5-methyl-pyrazole-3-carbonitrile; l-[6-[6-fluoro-5-(2,3,4-trifluoroanilino)benzimidazol-l-yl]- 3-(l-hydroxyethyl)-2-pyridyl]-5- methyl-pyrazole-3 -carbonitrile; l-[6-[5-fluoro-6-(2,3,4-trifluoroanilino)benzimidazol-l-yl]- 3-(l-hydroxyethyl)-2-pyridyl]-5- methyl-pyrazole-3 -carbonitrile;

N-[l-[6-(3-cyano-5-methyl-pyrazol-l-yl)-5-(l-hydroxyethyl )-2-pyridyl]benzimidazol-5-yl]-l- fluoro-cyclopropanecarboxamide; l-[6-[6-(6,7-dihydro-5~{H}-cyclopenta[c]pyridazin-3-ylamino) -5-fluoro-benzimidazol-l-yl]-3- (l-hydroxyethyl)-2-pyridyl]-5-methyl-pyrazole-3-carbonitrile ; l-[6-[5-(6,7-dihydro-5~{H}-cyclopenta[c]pyridazin-3-ylamino) -6-fluoro-benzimidazol-l-yl]-3- (l-hydroxyethyl)-2-pyridyl]-5-methyl-pyrazole-3-carbonitrile ;

(lS)-l-[2-[3-(difluoromethoxy)-5-methyl-pyrazol-l-yl]-6-[ 5-[(6-methylpyridazin-3-yl)amino]-6- (ox etan-3 -yl oxy)b enzimi dazol - 1 -yl ] -3 -pyri dyl ] ethanol ;

(lR)-l-[2-[3-(difluoromethoxy)-5-methyl-pyrazol-l-yl]-6-[ 5-[(6-methylpyridazin-3-yl)amino]-6- (ox etan-3 -yl oxy)b enzimi dazol - 1 -yl ] -3 -pyri dyl ] ethanol ;

1-[6-[6-fluoro-5-[(5-methyl-l, 3, 4-thiadiazol-2-yl)amino]benzimidazol-l-yl]-3-(l -hydroxyethyl)-

2-pyridyl]-5-methyl-pyrazole-3-carbonitrile;

3-fluoro-4-[3-(l-hydroxyethyl)-6-[5-[(6-methylpyridazin-3 -yl)amino]benzimidazol-l-yl]-2- pyridyl]-l-(2,2,2-trifluoroethyl)pyridin-2-one; l-[2-[3,5-bis(difluoromethyl)pyrazol-l-yl]-6-[6-fluoro-5-[(6 -methylpyridazin-3- yl)ami no]b enzimi dazol - 1 -yl ] -3 -pyri dyl ] ethanol ; l-[6-[6-(difluoromethoxy)-5-[(6-methylpyridazin-3-yl)amino]b enzimidazol-l-yl]-3-(l- hydroxyethyl)-2-pyridyl]-5-methyl-pyrazole-3-carbonitrile; l-[6-[6-fluoro-5-[(5-fluoro-6-methyl-3-pyridyl)amino]benzimi dazol-l-yl]-3-(l-hydroxyethyl)-2- pyridyl]-5-methyl-pyrazole-3-carbonitrile; l-[6-[5-[[5-(azetidin-l-yl)pyridazin-3-yl]amino]-6-fluoro-be nzimidazol-l-yl]-2-[3- (difluoromethyl)-5-methyl-pyrazol-l-yl]-3-pyridyl]ethanol; l-[6-[6-fluoro-5-[(5-fluoro-6-methyl-3-pyridyl)amino]benzimi dazol-l-yl]-3-[(lS)-l- hydroxyethyl]-2-pyridyl]-5-methyl-pyrazole-3-carbonitrile; l-[3-(l-hydroxyethyl)-6-[5-[2-(2-oxopyrrolidin-l-yl)oxazol-5 -yl]benzimidazol-l-yl]-2-pyridyl]- 5-methyl-pyrazole-3-carbonitrile; l-[2-(4,4-difluoropyrrolidin-3-yl)oxy-6-[5-[(6-methylpyridaz in-3-yl)amino]benzimidazol-l-yl]- 3-pyridyl]ethanol; l-[6-[5-(7,8-dihydro-5~{H}-pyrano[4,3-c]pyridazin-3-ylamino) -6-methoxy-benzimidazol-l-yl]- 3-(l-hydroxyethyl)-2-pyridyl]-5-methyl-pyrazole-3-carbonitri le; l-[3-(l-hydroxyethyl)-6-[6-[2-(2-oxopyrrolidin-l-yl)oxazol-5 -yl]benzimidazol-l-yl]-2-pyridyl]- 5-methyl-pyrazole-3-carbonitrile; l-[2-[6-(difluoromethoxy)-3-methyl-pyridazin-4-yl]-6-[5-[(6- methylpyridazin-3- yl)ami no]b enzimi dazol - 1 -yl ] -3 -pyri dyl ] ethanol ; l-[2-[3-(difluoromethyl)-5-methoxy-pyrazol-l-yl]-6-[6-[(6-me thylpyridazin-3- yl)ami no]b enzimi dazol - 1 -yl ] -3 -pyri dyl ] ethanol ; l-[2-[3-(difluoromethyl)-5-methoxy-pyrazol-l-yl]-6-[5-[(6-me thylpyridazin-3- yl)ami no]b enzimi dazol - 1 -yl ] -3 -pyri dyl ] ethanol ; l-[2-[l-(2,3-difluoropropyl)-3-methyl-pyrazol-4-yl]-6-[5-[(6 -methylpyridazin-3- yl)ami no]b enzimi dazol - 1 -yl ] -3 -pyri dyl ] ethanol ;

(lS)-l-[2-[3-(difluoromethoxy)-5-methyl-pyrazol-l-yl]-6-[ 6-methoxy-5-[(2-methylpyrimidin-5- yl)ami no]b enzimi dazol - 1 -yl ] -3 -pyri dyl ] ethanol ; l-[6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-l-yl]-2- [2-methyl-5-(2,2,2-trifluoroethyl)- l,2,4-triazol-3-yl]-3-pyridyl]ethanol; l-[6-[6-(difluoromethoxy)-5-[(6-methylpyridazin-3-yl)amino]b enzimidazol-l-yl]-3-[(lS)-l- hydroxyethyl]-2-pyridyl]-5-methyl-pyrazole-3-carbonitrile; l-[6-[6-(difluoromethoxy)-5-[(6-methylpyridazin-3-yl)amino]b enzimidazol-l-yl]-3-[(lR)-l- hydroxyethyl]-2-pyridyl]-5-methyl-pyrazole-3-carbonitrile; l-[2-[3-(difluoromethoxy)-5-(difluoromethyl)pyrazol-l-yl]-6- [5-[(6-methylpyridazin-3- yl)ami no]b enzimi dazol - 1 -yl ] -3 -pyri dyl ] ethanol ; l-[2-[3-(difluoromethoxy)-5-(difluoromethyl)pyrazol-l-yl]-6- [6-[(6-methylpyridazin-3- yl)ami no]b enzimi dazol - 1 -yl ] -3 -pyri dyl ] ethanol ; l-[2-[3-(difluoromethoxy)-5-methyl-pyrazol-l-yl]-6-[6-[(6-me thylpyridazin-3-yl)amino]-5-

(ox etan-3 -ylmethyl)b enzimi dazol - 1 -yl ] -3 -pyri dyl ] ethanol ; and l-[2-[3-(difluoromethoxy)-5-methyl-pyrazol-l-yl]-6-[5-[(6-me thylpyridazin-3-yl)amino]-6- (ox etan-3 -ylmethyl)b enzimi dazol - 1 -yl ] -3 -pyri dyl ] ethanol ; or a pharmaceutically acceptable salt thereof.

67. A compound according to any one of embodiments 1 to 66, selected from

[2-(3-chlorophenyl)-6-(5,6-dimethoxybenzimidazol-l-yl)-3- pyridyl]methanol;

(2-(3-chloro-2-fluorophenyl)-6-(5,6-dimethoxy-lH-benzo[d] imidazol-l-yl)pyri din-3- yl)methanol;

(6-(5,6-dimethoxy-lH-benzo[d]imidazol-l-yl)-2-(4-fluoro-2 -methoxyphenyl)pyri din-3- yl)methanol; l-(6-(5,6-dimethoxy-lH-benzo[d]imidazol-l-yl)-2-(4-fluoro-2- methoxyphenyl)pyri din-3- yl)ethan-l-ol; l-(6-(5,6-dimethoxy-lH-benzo[d]imidazol-l-yl)-2-(4-fluoro-2- methoxyphenyl)pyri din-3- yl)propan-l-ol;

1 -(2-(3 -chlorophenyl)-6-(5,6-dimethoxy- lH-benzo[d]imidazol- 1 -yl)pyri din-3 -yl)ethan- 1 -ol; l-(2-(3-chloro-2-fluorophenyl)-6-(5,6-dimethoxy-lH-benzo[d]i midazol-l-yl)pyridin-3-yl)ethan- l-ol;

(S)-l-(6-(5,6-dimethoxy-lH-benzo[d]imidazol-l-yl)-2-(4-fl uoro-2-methoxyphenyl)pyri din-3- yl)ethan-l-ol; (R)-l-(6-(5,6-dimethoxy-lH-benzo[d]imidazol-l-yl)-2-(4-fluor o-2-methoxyphenyl)pyri din-3- yl)ethan-l-ol; cyclopropyl(6-(5,6-dimethoxy-lH-benzo[d]imidazol-l-yl)-2-(4- fluoro-2-methoxyphenyl)pyridin-

3 -yl)m ethanol; l-(2-(3-chlorophenyl)-6-(5,6-dimethoxy-lH-benzo[d]imidazol-l -yl)pyridin-3-yl)propan-l-ol;

(2-(3-chlorophenyl)-6-(5,6-dimethoxy-lH-benzo[d]imidazol- l-yl)pyri din-3- yl)(cyclopropyl)methanol;

(6-(5,6-dimethoxy-lH-benzo[d]imidazol-l-yl)-2-morpholinop yridin-3-yl)methanol;

(6-(5,6-dimethoxy-lH-benzo[d]imidazol-l-yl)-2-(pyrrolidin -l-yl)pyridin-3-yl)methanol;

(6-(5,6-dimethoxy-lH-benzo[d]imidazol-l-yl)-2-(piperidin- l-yl)pyridin-3-yl)methanol;

5-((6-(5,6-dimethoxy-lH-benzo[d]imidazol-l-yl)-3-(hydroxy methyl)pyridin-2-yl)amino)pentan- l-ol; l-(6-(5,6-dimethoxy-lH-benzo[d]imidazol-l-yl)-3-(hydroxymeth yl)pyridin-2-yl)pyrrolidin-2- one;

4-((6-(5,6-dimethoxy- lH-benzo[d]imidazol- 1 -yl)-3-(hydroxymethyl)pyri din-2 -yl)amino)butan- 1 - ol;

(S)-2-(6-(5,6-dimethoxy-lH-benzo[d]imidazol-l-yl)-3-(l-hy droxyethyl)pyridin-2-yl)benzamide;

(R)-2-(6-(5,6-dimethoxy-lH-benzo[d]imidazol-l-yl)-3-(l-hy droxyethyl)pyridin-2-yl)benzamide;

(S)-3-(6-(5,6-dimethoxy-lH-benzo[d]imidazol-l-yl)-3-(l-hy droxyethyl)pyridin-2- yl)benzonitrile;

(R)-3-(6-(5,6-dimethoxy-lH-benzo[d]imidazol-l-yl)-3-(l-hy droxyethyl)pyri din-2- yl)benzonitrile;

(S)-4-(6-(5,6-dimethoxy-lH-benzo[d]imidazol-l-yl)-3-(l-hy droxyethyl)pyridin-2- yl)benzonitrile; (R)-4-(6-(5,6-dimethoxy-lH-benzo[d]imidazol-l-yl)-3-(l-hydro xyethyl)pyridin-2- yl)benzonitrile;

(S)-6-(5,6-dimethoxy-lH-benzo[d]imidazol-l-yl)-3-(l -hydroxyethyl)- l'-methyl-[2,4'-bipyridin]- 2'(l'H)-one;

(R)-6-(5,6-dimethoxy-lH-benzo[d]imidazol-l-yl)-3-(l-hydro xyethyl)-r-methyl-[2,4'-bipyridin]- 2'(l'H)-one; l-[6-[5-(2-morpholinoethoxy)benzimidazol-l-yl]-2-phenoxy-3-p yridyl]ethanol; l-[2-anilino-6-[5-(2-morpholinoethoxy)benzimidazol-l-yl]-3-p yridyl]ethanol; l-[6-[5-(2-morpholinoethoxy)benzimidazol-l-yl]-2-[3-(trifluo romethyl)pyrazol-l-yl]-3- pyridyl] ethanol; l-[6-(5,6-dimethoxybenzimidazol-l-yl)-2-[3-(trifluoromethyl) pyrazol-l-yl]-3-pyridyl]ethanol; l-[3-(l-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino]be nzimidazol-l-yl]-2-pyridyl]-5- methyl-pyrazole-3 -carbonitrile; l-[3-(l-hydroxyethyl)-6-[5-(4-methylpiperazin-l-yl)benzimida zol-l-yl]-2-pyridyl]-5-methyl- pyrazole-3 -carbonitrile; l-[3-(l-hydroxyethyl)-6-[5-[4-(oxetan-3-yl)piperazin-l-yl]be nzimidazol-l-yl]-2-pyridyl]-5- methyl-pyrazole-3 -carbonitrile; l-[3-(l-hydroxyethyl)-6-[5-(2 -morpholinoethoxy )benzimidazol-l -yl]-2-pyri dyl]-5-methyl- pyrazole-3 -carbonitrile; l-[3-(l-hydroxyethyl)-6-[5-[[l-(oxetan-3-yl)pyrazol-4-yl]ami no]benzimidazol-l-yl]-2-pyridyl]- 5-methyl-pyrazole-3-carbonitrile; l-[6-[5-[[l-(azetidin-3-yl)pyrazol-4-yl]amino]benzimidazol-l -yl]-3-(l-hydroxyethyl)-2-pyridyl]- 5-methyl-pyrazole-3-carbonitrile; l-[3-(l-hydroxyethyl)-6-[6-(6-methylpyridazin-3-yl)oxybenzim idazol-l-yl]-2-pyridyl]-5-methyl- pyrazole-3 -carbonitrile; l-[3-(l-hydroxyethyl)-6-[5-(6-methylpyridazin-3-yl)oxybenzim idazol-l-yl]-2-pyridyl]-5-methyl- pyrazole-3 -carbonitrile;

5-[3-(l-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino ]benzimidazol-l-yl]-2-pyridyl]-l- methyl-pyrazole-4-carbonitrile; l-[3-(l-hydroxyethyl)-6-[5-[rac-(3R)-3-hydroxypyrrolidin-l-y l]benzimidazol-l-yl]-2-pyridyl]-5- methyl-pyrazole-3 -carbonitrile; l-[3-(l-hydroxyethyl)-6-[5-[(3S)-3-hydroxypyrrolidin-l-yl]be nzimidazol-l-yl]-2-pyridyl]-5- methyl-pyrazole-3 -carbonitrile; l-[3-(l-hydroxyethyl)-6-[5-[(6-methyl-3-pyridyl)amino]benzim idazol-l-yl]-2-pyridyl]-5-methyl- pyrazole-3 -carbonitrile; l-[3-(l-hydroxyethyl)-6-[5-[(5-methylpyrazin-2-yl)amino]benz imidazol-l-yl]-2-pyridyl]-5- methyl-pyrazole-3 -carbonitrile; l-[3-(l-hydroxyethyl)-6-[5-[(5-methylpyrimidin-2-yl)amino]be nzimidazol-l-yl]-2-pyridyl]-5- methyl-pyrazole-3 -carbonitrile; l-[3-(l-hydroxyethyl)-6-[5-[(5-methyl-2-pyridyl)amino]benzim idazol-l-yl]-2-pyridyl]-5-methyl- pyrazole-3 -carbonitrile; l-[2-(l, 1 -di oxo-1, 2-thi azolidin-2 -yl)-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-l-yl]- 3- pyridyl] ethanol; l-[3-(l-hydroxyethyl)-6-[5-[(2-methylpyrimidin-5-yl)amino]be nzimidazol-l-yl]-2-pyridyl]-5- methyl-pyrazole-3 -carbonitrile; l-[3-(l-hydroxyethyl)-6-[5-(pyridazin-4-ylamino)benzimidazol -l-yl]-2-pyridyl]-5-methyl- pyrazole-3 -carbonitrile; l-[3-(l-hydroxyethyl)-6-[5-[(6-methoxypyridazin-3-yl)amino]b enzimidazol-l-yl]-2-pyridyl]-5- methyl-pyrazole-3 -carbonitrile; l-[3-(l-hydroxyethyl)-6-[5-(pyridazin-3-ylamino)benzimidazol -l-yl]-2-pyridyl]-5-methyl- pyrazole-3 -carbonitrile; l-[6-[5-[[6-(difluoromethyl)pyridazin-3-yl]amino]benzimidazo l-l-yl]-3-(l-hydroxyethyl)-2- pyridyl]-5-methyl-pyrazole-3-carbonitrile; l-[6-[6-fluoro-5-[(6-methylpyridazin-3-yl)amino]benzimidazol -l-yl]-3-(l-hydroxyethyl)-2- pyridyl]-5-methyl-pyrazole-3-carbonitrile; l-[6-[5-fluoro-6-[(6-methylpyridazin-3-yl)amino]benzimidazol -l-yl]-3-(l-hydroxyethyl)-2- pyridyl]-5-methyl-pyrazole-3-carbonitrile; l-[6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-l-yl]-2- [3-(trifluoromethyl)-4,5,6,7- tetrahydropyrazolo[4,3-c]pyridin-l-yl]-3-pyridyl]ethanol; l-[6-[6-[(6-methylpyridazin-3-yl)amino]benzimidazol-l-yl]-2- [3-(trifluoromethyl)-4,5,6,7- tetrahydropyrazolo[4,3-c]pyridin-l-yl]-3-pyridyl]ethanol;

1-[3-(l-hydroxyethyl)-6-[5-[(5-methyl-l,3,4-oxadiazol-2-y l)amino]benzimidazol-l-yl]-2- pyridyl]-5-methyl-pyrazole-3-carbonitrile;

2-[3-(l-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino ]benzimidazol-l-yl]-2-pyridyl]-5- methyl-pyrazole-3 -carbonitrile;

(3R)- 1 -[3 -(1 -hydroxy ethyl)-6-[6-[(6-m ethyl pyridazin-3 -yl)amino]benzimidazol- 1 -yl] -2- pyridyl]pyrrolidine-3-carbonitrile; rac-(3R)-l-[3-(l-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl )amino]benzimidazol-l-yl]-2- pyridyl]pyrrolidine-3-carbonitrile; l-[2-(3,5-dimethylpyrazol-l-yl)-6-[6-[(6-methylpyridazin-3-y l)amino]benzimidazol-l-yl]-3- pyridyl] ethanol; l-[2-(3,5-dimethylpyrazol-l-yl)-6-[5-[(6-methylpyridazin-3-y l)amino]benzimidazol-l-yl]-3- pyridyl] ethanol;

5-methyl-l-[6-[5-[(6-methylpyridazin-3-yl)amino]benzimida zol-l-yl]-3-[rac-(lR)-l- hydroxyethyl]-2-pyridyl]pyrazole-3-carbonitrile;

5-methyl-l-[6-[5-[(6-methylpyridazin-3-yl)amino]benzimida zol-l-yl]-3-[rac-(lS)-l- hydroxyethyl]-2-pyridyl]pyrazole-3-carbonitrile; l-[3-(l-hydroxyethyl)-6-[5-[(5-methyl-l,3,4-thiadiazol-2-yl) amino]benzimidazol-l-yl]-2- pyridyl]-5-methyl-pyrazole-3-carbonitrile; l-[3-(l-hydroxyethyl)-6-[5-[[l-(oxetan-3-yl)-4-piperidyl]oxy ]benzimidazol-l-yl]-2-pyridyl]-5- methyl-pyrazole-3 -carbonitrile; l-[3-(l-hydroxyethyl)-6-[6-[[l-(oxetan-3-yl)-4-piperidyl]oxy ]benzimidazol-l-yl]-2-pyridyl]-5- methyl-pyrazole-3 -carbonitrile; l-[3-(l-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino]be nzimidazol-l-yl]-2- pyridyl]pyrazole-3-carbonitrile; l-[[[3-(l-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino] benzimidazol-l-yl]-2- pyridyl]amino]methyl]cyclopropanecarbonitrile; l-[[[3-(l-hydroxyethyl)-6-[6-[(6-methylpyridazin-3-yl)amino] benzimidazol-l-yl]-2- pyridyl]amino]methyl]cyclopropanecarbonitrile;

5-[3-(l-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino ]benzimidazol-l-yl]-2- pyridyl]pyridine-3 -carbonitrile; l-[3-(l-hydroxyethyl)-6-[5-(l,2,4-triazin-3-ylamino)benzimid azol-l-yl]-2-pyridyl]-5-methyl- pyrazole-3 -carbonitrile; l-[3-(l-hydroxyethyl)-6-[6-[(6-methylpyridazin-3-yl)amino]be nzimidazol-l-yl]-2-pyridyl]-3- methyl-pyrrolidine-3-carbonitrile; l-[3-(l-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino]be nzimidazol-l-yl]-2-pyridyl]-3- methyl-pyrrolidine-3-carbonitrile; l-[6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-l-yl]-2- [2-methyl-5- (trifluoromethyl)pyrazol -3 -yl ] -3 -pyri dyl ] ethanol ; l-[3-(l-hydroxyethyl)-6-[5-(isoxazol-3-ylamino)benzimidazol- l-yl]-2-pyridyl]-5-methyl- pyrazole-3 -carbonitrile;

3-(l-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino]be nzimidazol-l-yl]-N-(2,2,2- trifluoroethyl)pyridine-2-carboxamide; l-[6-[6-[(6-methylpyridazin-3-yl)amino]benzimidazol-l-yl]-2- [rac-(3aR,6aS)-2,3,3a,5,6,6a- hexahydro- 1 H-pyrrolo [ 3 ,2-b ] pyrrol -4-yl ] -3 -pyri dyl ] ethanol ; l-[6-[6-[(6-methylpyridazin-3-yl)amino]benzimidazol-l-yl]-2- [rac-(3aS,6aR)-2,3,3a,5,6,6a- hexahy dro- 1 H-pyrrolo [ 3 ,2-b ] pyrrol -4-yl ] -3 -pyri dyl ] ethanol ; l-[6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-l-yl]-2- [rac-(3aR,6aS)-2,3,3a,5,6,6a- hexahy dro- 1 H-pyrrolo [ 3 ,2-b ] pyrrol -4-yl ] -3 -pyri dyl ] ethanol ; l-[2-[3-(difluoromethyl)-5-methyl-pyrazol-l-yl]-6-[6-[(6-met hylpyridazin-3- yl)ami no]b enzimi dazol - 1 -yl ] -3 -pyri dyl ] ethanol ; l-[2-[3-(difluoromethyl)-5-methyl-pyrazol-l-yl]-6-[5-[(6-met hylpyridazin-3- yl)ami no]b enzimi dazol - 1 -yl ] -3 -pyri dyl ] ethanol ; l-[6-[6-bromo-5-[4-(oxetan-3-yl)piperazin-l-yl]benzimidazol- l-yl]-3-(l-hydroxyethyl)-2- pyridyl]-5-methyl-pyrazole-3-carbonitrile; l-[2-(3-ethoxy-5-methyl-pyrazol-l-yl)-6-[5-[(6-methylpyridaz in-3-yl)amino]benzimidazol-l-yl]- 3-pyridyl]ethanol; l-[2-(3-ethoxy-5-methyl-pyrazol-l-yl)-6-[6-[(6-methylpyridaz in-3-yl)amino]benzimidazol-l-yl]-

3-pyridyl]ethanol; l-[2-(6-methylpyridazin-4-yl)-6-[5-[(6-methylpyridazin-3-yl) amino]benzimidazol-l-yl]-3- pyri dyl] ethanol;

4-[3-(l-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino ]benzimidazol-l-yl]-2-pyridyl]-l- (2,2,2-trifluoroethyl)piperazin-2-one;

4-[3-(l-hydroxyethyl)-6-[6-[(6-methylpyridazin-3-yl)amino ]benzimidazol-l-yl]-2-pyridyl]-l- (2,2,2-trifluoroethyl)piperazin-2-one; l-[[3-(l-hydroxyethyl)-6-[6-[(6-methylpyridazin-3-yl)amino]b enzimidazol-l-yl]-2- pyri dyl ] oxym ethyl ] cy cl opropanecarb onitril e ; l-[[3-(l-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino]b enzimidazol-l-yl]-2- pyri dyl ] oxym ethyl ] cy cl opropanecarb onitril e ; l-[3-(l-hydroxyethyl)-6-[5-methoxy-6-[(6-methylpyridazin-3-y l)amino]benzimidazol-l-yl]-2- pyridyl]-5-methyl-pyrazole-3-carbonitrile; l-[6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-l-yl]-2- [3-methyl-l -(2,2,2- trifluoroethyl)pyrazol-4-yl]-3-pyridyl]ethanol; l-[3-(l-hydroxyethyl)-6-[6-[(6-methylpyridazin-3-yl)amino]be nzimidazol-l-yl]-2-pyridyl]-N,5- dimethyl-pyrazole-3-carboxamide; l-[2-(5-methyl-3-methylsulfonyl-pyrazol-l-yl)-6-[5-[(6-methy lpyridazin-3- yl)ami no]b enzimi dazol - 1 -yl ] -3 -pyri dyl ] ethanol ;

1 -[3 -(1 -hydroxy ethy l)-6- [ 5 - [(2 -keto- 1 -m ethyl -pyrimidin-4-yl)amino]benzimidazol- 1 -yl] -2- pyridyl]-5-methyl-pyrazole-3-carbonitrile;

5-methyl-l-[6-[5-[(6-methylpyridazin-3-yl)amino]benzimida zol-l-yl]-3-(2,2,2-trifluoro-l- hydroxy-ethyl)-2-pyridyl]pyrazole-3-carbonitrile; l-[2-[l-(difluoromethyl)-3-methyl-pyrazol-4-yl]-6-[5-[(6-met hylpyridazin-3- yl)ami no]b enzimi dazol - 1 -yl ] -3 -pyri dyl ] ethanol ; l-[3-(l-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino]be nzimidazol-l-yl]-2-pyridyl]-5- methyl-pyrazole-4-carbonitrile; l-[3-(l-hydroxyethyl)-6-[6-[(6-methylpyridazin-3-yl)amino]be nzimidazol-l-yl]-2-pyridyl]-5- methyl-pyrazole-4-carbonitrile; l-[3-(l-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino]be nzimidazol-l-yl]-2-pyridyl]-N,5- dimethyl-pyrazole-3-carboxamide; l-[3-(l-hydroxyethyl)-6-[5-[(2-keto-l-methyl-4-piperidyl)ami no]benzimidazol-l-yl]-2-pyridyl]- 5-methyl-pyrazole-3-carbonitrile;

[2-(3-methoxy-5-methyl-pyrazol-l-yl)-6-[5-[(6-methylpyrid azin-3-yl)amino]benzimidazol-l-yl]- 3 -pyri dyl] methanol ; l-[2-(3,5-dimethylisoxazol-4-yl)-6-[5-[(6-methylpyridazin-3- yl)amino]benzimidazol-l-yl]-3- pyri dyl] ethanol; l-[3-(l-hydroxyethyl)-6-[5-[(4-methoxypyridazin-3-yl)amino]b enzimidazol-l-yl]-2-pyridyl]-5- methyl-pyrazole-3 -carbonitrile; l-[3-(l-hydroxyethyl)-6-[5-[(5-keto-l-methyl-pyrrolidin-3-yl )amino]benzimidazol-l-yl]-2- pyridyl]-5-methyl-pyrazole-3-carbonitrile; l-[6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-l-yl]-2- (3-methyl-4-pyridyl)-3- pyridyl] ethanol; l-[2-[4-(cyclopropylamino)pyrimidin-5-yl]-6-[5-[(6-methylpyr idazin-3-yl)amino]benzimidazol-

1 -yl ] -3 -pyri dyl ] ethanol ;

5-[3-(l-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino ]benzimidazol-l-yl]-2-pyridyl]-4- (trifluoromethyl)pyridin-2-ol;

3-[3-(l-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino ]benzimidazol-l-yl]-2-pyridyl]-6,7- dihydro-5H-pyrazolo[l,5-a]pyrazin-4-one; l-[6-[6-fluoro-5-[[(3S,4R)-4-fluoropyrrolidin-3-yl]amino]ben zimidazol-l-yl]-3-(l- hydroxyethyl)-2-pyridyl]-5-methyl-pyrazole-3-carbonitrile; l-[2-[2-(difluoromethoxy)-5-methyl-4-pyridyl]-6-[5-[(6-methy lpyridazin-3- yl)ami no]b enzimi dazol - 1 -yl ] -3 -pyri dyl ] ethanol ; l-[2-(2-fluoro-5-methyl-4-pyridyl)-6-[5-[(6-methylpyridazin- 3-yl)amino]benzimidazol-l-yl]-3- pyri dyl] ethanol; l-[3-(l-hydroxyethyl)-6-[6-[(6-methylpyridazin-3-yl)amino]be nzimidazol-l-yl]-2-pyridyl]-4- methyl-pyrazole-3 -carbonitrile; l-[3-(l-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino]be nzimidazol-l-yl]-2-pyridyl]-4- methyl-pyrazole-3 -carbonitrile; l-[6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-l-yl]-2- [5-methyl-3-(trifluoromethyl)-6,7- dihydro-4H-pyrazol o [4, 3 -c] pyri din- 1 -yl ] -3 -pyri dyl ] ethanol ; l-[[[3-(l-hydroxyethyl)-6-[6-[(6-methylpyridazin-3-yl)amino] benzimidazol-l-yl]-2-pyridyl]- methyl-amino]methyl]cyclopropanecarbonitrile; l-[[[3-(l-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino] benzimidazol-l-yl]-2-pyridyl]- methyl-amino]methyl]cyclopropanecarbonitrile; l-[2-(2-chloro-5-fluoro-3-pyridyl)-6-[5-[(6-methylpyridazin- 3-yl)amino]benzimidazol-l-yl]-3- pyridyl] ethanol; l-[3-(l-hydroxyethyl)-6-[6-[[6-[(3-methoxyazetidin-l-yl)meth yl]pyridazin-3- yl]amino]benzimidazol-l-yl]-2-pyridyl]-5-methyl-pyrazole-3-c arbonitrile; l-[3-(l-hydroxyethyl)-6-[5-[[6-[(3-methoxyazetidin-l-yl)meth yl]pyridazin-3- yl]amino]benzimidazol-l-yl]-2-pyridyl]-5-methyl-pyrazole-3-c arbonitrile; l-[6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-l-yl]-2- [5-(oxetan-3-yl)-3-

(trifluoromethyl)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-l -yl]-3-pyridyl]ethanol; l-[3-(l-hydroxyethyl)-6-[6-[(6-methylpyridazin-3-yl)amino]be nzimidazol-l-yl]-2-pyridyl]-3- methyl-pyrazole-4-carbonitrile; l-[2-[2-(methylamino)-3-pyridyl]-6-[5-[(6-methylpyridazin-3- yl)amino]benzimidazol-l-yl]-3- pyridyl] ethanol; l-[3-(l-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino]be nzimidazol-l-yl]-2-pyridyl]-3- methyl-pyrazole-4-carbonitrile; l-[3-(l-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino]be nzimidazol-l-yl]-2-pyridyl]-3- methyl-azetidine-3 -carbonitrile; l-[3-(l-hydroxyethyl)-6-[6-[(6-methylpyridazin-3-yl)amino]be nzimidazol-l-yl]-2-pyridyl]-3- methyl-azetidine-3 -carbonitrile; l-[3-(l-hydroxyethyl)-6-[6-methoxy-5-[(6-methylpyridazin-3-y l)amino]benzimidazol-l-yl]-2- pyridyl]-5-methyl-pyrazole-3-carbonitrile; l-[6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-l-yl]-2- [2-(lH-pyrazol-4-yl)-3-pyridyl]-3- pyridyl] ethanol; l-[3-(l-hydroxyethyl)-6-[6-(2-methoxyethoxy)-5-[(6-methylpyr idazin-3-yl)amino]benzimidazol- l-yl]-2-pyridyl]-5-methyl-pyrazole-3-carbonitrile; l-[6-[5-fluoro-6-[[rac-(3R,4S)-4-fluoropyrrolidin-3-yl]amino ]benzimidazol-l-yl]-3-(l- hydroxyethyl)pyri din-2 -yl]-5-methylpyrazole-3-carbonitrile; l-[6-[6-[2-(dimethylamino)ethoxy]-5-[(6-methylpyridazin-3-yl )amino]benzimidazol-l-yl]-3-(l- hydroxyethyl)-2-pyridyl]-5-methyl-pyrazole-3-carbonitrile; l-[6-[5-bromo-6-[4-(oxetan-3-yl)piperazino]benzimidazol-l-yl ]-3-(l-hydroxyethyl)-2-pyridyl]- 5-methyl-pyrazole-3-carbonitrile; l-[3-(l-hydroxyethyl)-6-[5-[[6-(3-methoxyazetidine-l-carbony l)pyridazin-3- yl]amino]benzimidazol-l-yl]-2-pyridyl]-5-methyl-pyrazole-3-c arbonitrile; l-[3-(l-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino]-6 -pyrrolidin-3-yloxy-benzimidazol- l-yl]-2-pyridyl]-5-methyl-pyrazole-3-carbonitrile; l-[3-(l-hydroxyethyl)-6-[5-[[6-(2-methoxyethoxy)pyridazin-3- yl]amino]benzimidazol-l-yl]-2- pyridyl]-5-methyl-pyrazole-3-carbonitrile; l-[2-(lH-benzotriazol-4-yl)-6-[5-[(6-methylpyridazin-3-yl)am ino]benzimidazol-l-yl]-3- pyridyl] ethanol; l-[6-[5-[[6-(2,2-difluoroethoxy)pyridazin-3-yl]amino]benzimi dazol-l-yl]-3-(l-hydroxyethyl)-2- pyridyl]-5-methyl-pyrazole-3-carbonitrile; l-[6-[5-[[6-(difluoromethoxy)pyridazin-3-yl]amino]benzimidaz ol-l-yl]-3-(l-hydroxyethyl)-2- pyridyl]-5-methyl-pyrazole-3-carbonitrile; l-[3-(2,2-difluoro-l-hydroxy-ethyl)-6-[5-[(6-methylpyridazin -3-yl)amino]benzimidazol-l-yl]-2- pyridyl]-5-methyl-pyrazole-3-carbonitrile;

1 -[3 -(2,2-difluoro- 1 -hy droxy-ethyl)-6-[6-[(6-m ethyl pyridazin-3 -yl)amino]benzimidazol- 1 -yl] -2- pyridyl]-5-methyl-pyrazole-3-carbonitrile;

1 -[6-[6-[( 1 , 1 -di oxo- 1 ,2-thiazolidin-2-yl)methyl]benzimidazol- 1 -yl] -3 -( 1 -hydroxyethyl)-2- pyridyl]-5-methyl-pyrazole-3-carbonitrile;

1 -[6-[5-[(l,l -dioxo- 1,2-thi azolidin-2-yl)methyl]benzimidazol-l -yl]-3-(l -hydroxyethyl)-2- pyridyl]-5-methyl-pyrazole-3-carbonitrile; 3-[3-(l-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino]be nzimidazol-l-yl]-2-pyridyl]-2- methoxy-phenol ;

3-[3-(l-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino ]benzimidazol-l-yl]-2-pyridyl]furan-

2-carbonitrile; l-[3-(l-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino]be nzimidazol-l-yl]pyri din-2 -yl]- 4,5,6,7-tetrahydropyrazolo[4,3-c]pyridine-3-carbonitrile; l-[6-[5-[[6-[2-(l,l-diketo-l,4-thiazinan-4-yl)ethoxy]pyridaz in-3-yl]amino]benzimidazol-l-yl]-3- (l-hydroxyethyl)-2-pyridyl]-5-methyl-pyrazole-3-carbonitrile ; l-[3-(l-hydroxyethyl)-6-[5-[[6-(oxetan-3-yloxy)pyridazin-3-y l]amino]benzimidazol-l-yl]-2- pyridyl]-5-methyl-pyrazole-3-carbonitrile; l-[6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-l-yl]-2- [(3S)-pyrrolidin-3-yl]oxy-3- pyridyl] ethanol; l-[3-(l-hydroxyethyl)-6-[6-[(2-oxopyrrolidin-l-yl)methyl]ben zimidazol-l-yl]-2-pyridyl]-5- methyl-pyrazole-3 -carbonitrile; l-[3-(l-hydroxyethyl)-6-[5-[(2-oxopyrrolidin-l-yl)methyl]ben zimidazol-l-yl]-2-pyridyl]-5- methyl-pyrazole-3 -carbonitrile; l-[2-(3-methoxy-5-methyl-pyrazol-l-yl)-6-[5-[(6-methylpyrida zin-3-yl)amino]benzimidazol-l- yl]-3-pyridyl]ethanol; l-[3-(l-hydroxyethyl)-6-[6-[(2-oxo-l-piperidyl)methyl]benzim idazol-l-yl]-2-pyridyl]-5-methyl- pyrazole-3 -carbonitrile; l-[3-(l-hydroxyethyl)-6-[5-[(2-oxo-l-piperidyl)methyl]benzim idazol-l-yl]-2-pyridyl]-5-methyl- pyrazole-3 -carbonitrile;

3-[[l-[6-(3-cyano-5-methyl-pyrazol-l-yl)-5-(l-hydroxyethy l)-2-pyridyl]benzimidazol-5- yl]amino]-N,N,6-trimethyl-pyridazine-4-carboxamide;

5-hydroxy-2-[3-(l-hydroxyethyl)-6-[5-[(6-methylpyridazin- 3-yl)amino]benzimidazol-l-yl]-2- pyridyl]benzonitrile; 5-[3-(l-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino]be nzimidazol-l-yl]-2-pyridyl]-3- (trifluoromethyl)-lH-pyridazin-6-one;

2-[3-(l-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino ]benzimidazol-l-yl]-2-pyridyl]furan-

3 -carbonitrile; l-[2-[2-(2,2-difluorocyclopropyl)pyrazol-3-yl]-6-[5-[(6-meth ylpyridazin-3- yl)ami no]b enzimi dazol - 1 -yl ] -3 -pyri dyl ] ethanol ; l-[3-(l-hydroxyethyl)-6-[5-[[6-(oxetan-3-yl)pyridazin-3-yl]a mino]benzimidazol-l-yl]-2- pyridyl]-5-methyl-pyrazole-3-carbonitrile;

(lS)-l-[2-[3-(difluoromethyl)-5-methyl-pyrazol-l-yl]-6-[5 -[(6-methylpyridazin-3- yl)ami no]b enzimi dazol - 1 -yl ] -3 -pyri dyl ] ethanol ;

(lR)-l-[2-[3-(difluoromethyl)-5-methyl-pyrazol-l-yl]-6-[5 -[(6-methylpyridazin-3- yl)ami no]b enzimi dazol - 1 -yl ] -3 -pyri dyl ] ethanol ; l-[2-[5-(difluoromethyl)-3-methyl-pyrazol-l-yl]-6-[5-[(6-met hylpyridazin-3- yl)ami no]b enzimi dazol - 1 -yl ] -3 -pyri dyl ] ethanol ; l-[3-(l-hydroxy-2-methoxy-ethyl)-6-[5-[(6-methylpyridazin-3- yl)amino]benzimidazol-l-yl]-2- pyridyl]-5-methyl-pyrazole-3-carbonitrile; l-[3-(l-hydroxy-2-methoxy-ethyl)-6-[6-[(6-methylpyridazin-3- yl)amino]benzimidazol-l-yl]-2- pyridyl]-5-methyl-pyrazole-3-carbonitrile; l-[6-[6-fluoro-5-[(6-methylpyridazin-3-yl)amino]benzimidazol -l-yl]-3-[(lS)-l-hydroxyethyl]-2- pyridyl]-5-methyl-pyrazole-3-carbonitrile; l-[6-[6-fluoro-5-[(6-methylpyridazin-3-yl)amino]benzimidazol -l-yl]-3-[(lR)-l-hydroxyethyl]-2- pyridyl]-5-methyl-pyrazole-3-carbonitrile; l-[5-chloro-3-(l-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl )amino]benzimidazol-l-yl]-2- pyridyl]pyrazole-3-carbonitrile; l-[6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-l-yl]-2- [5-methyl-l -(2,2,2- trifluoroethyl)pyrazol-4-yl]-3-pyridyl]ethanol; l-[6-[5-[(6-chloro-4-methoxy-pyridazin-3-yl)amino]benzimidaz ol-l-yl]-3-(l-hydroxyethyl)-2- pyridyl]-5-methyl-pyrazole-3-carbonitrile; rac-(3R,5S)-l-[3-(l-hydroxyethyl)-6-[5-[(6-methylpyridazin-3 -yl)amino]benzimidazol-l-yl]-2- pyridyl]-5-methyl-pyrrolidine-3-carbonitrile; l-[5-chloro-3-(l-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl )amino]benzimidazol-l-yl]-2- pyridyl]-5-methyl-pyrazole-3-carbonitrile;

5-[3-(l-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino ]benzimidazol-l-yl]-2-pyridyl]-2- methyl-pyrazole-3 -carbonitrile; l-[3-[(lR)-l-hydroxyethyl]-6-[6-[(6-methylpyridazin-3-yl)ami no]benzimidazol-l-yl]-2-pyridyl]- 5-methyl-pyrazole-3-carbonitrile; l-[2-[3,5-bis(difluorornethyl)pyrazol-l-yl]-6-[5-[(6-methylp yridazin-3-yl)amino]benzimidazol-

1 -yl ] Pyri din-3 -yl ] ethanol ; l-[3-(l-hydroxyethyl)-6-[5-[[6-(trifluoromethyl)pyridazin-3- yl]amino]benzimidazol-l-yl]-2- pyridyl]-5-methyl-pyrazole-3-carbonitrile; l-[2-[2-ethyl-5-(trifluoromethyl)pyrazol-3-yl]-6-[5-[(6-meth ylpyridazin-3- yl)ami no]b enzimi dazol - 1 -yl ] -3 -pyri dyl ] ethanol ; rac-(lS)-l-[6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol -l-yl]-2-[3-methyl-l -(2,2,2- trifluoroethyl)pyrazol-4-yl]-3-pyridyl]ethanol; rac-(lR)-l-[6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol -l-yl]-2-[3-methyl-l -(2,2,2- trifluoroethyl)pyrazol-4-yl]-3-pyridyl]ethanol; l-[3-(l-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino]be nzimidazol-l-yl]-2- pyridyl]triazole-4-carbonitrile;

(3S,5R)-l-[3-(l-hydroxyethyl)-6-[5-[(6-methylpyridazin-3- yl)amino]benzimidazol-l-yl]-2- pyridyl]-5-methyl-pyrrolidine-3-carbonitrile;

5-[3-(l-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino ]benzimidazol-l-yl]-2-pyridyl]-l- methyl-pyrazole-3 -carbonitrile; 2-[3-(l-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino]be nzimidazol-l-yl]-2- pyridyl]triazole-4-carbonitrile; l-[6-(3-cyano-5-methylpyrazol-l-yl)-5-(l-hydroxyethyl)pyridi n-2-yl]benzimidazole-5- carbonitrile; l-[2-(l-ethyl-3-methyl-pyrazol-4-yl)-6-[5-[(6-methylpyridazi n-3-yl)amino]benzimidazol-l-yl]-3- pyridyl] ethanol; l-[2-[l-(2-methoxyethyl)-3-methyl-pyrazol-4-yl]-6-[5-[(6-met hylpyridazin-3- yl)ami no]b enzimi dazol - 1 -yl ] -3 -pyri dyl ] ethanol ; l-[2-[l-(cyclopropylmethyl)-3-methyl-pyrazol-4-yl]-6-[5-[(6- methylpyridazin-3- yl)ami no]b enzimi dazol - 1 -yl ] -3 -pyri dyl ] ethanol ;

5-methyl-l-[3-methylol-6-[6-[(6-methylpyridazin-3-yl)amin o]benzimidazol-l-yl]-2- pyridyl]pyrazole-3-carbonitrile;

5-methyl-l-[3-methylol-6-[5-[(6-methylpyridazin-3-yl)amin o]benzimidazol-l-yl]-2- pyridyl]pyrazole-3-carbonitrile; l-[2-(l-ethyl-5-methyl-pyrazol-4-yl)-6-[5-[(6-methylpyridazi n-3-yl)amino]benzimidazol-l-yl]-3- pyri dyl] ethanol; l-[2-[l-(cyclopropylmethyl)-5-methyl-pyrazol-4-yl]-6-[5-[(6- methylpyridazin-3- yl)ami no]b enzimi dazol - 1 -yl ] -3 -pyri dyl ] ethanol ; l-[2-[l-(cyclobutylmethyl)-3-methyl-pyrazol-4-yl]-6-[5-[(6-m ethylpyridazin-3- yl)ami no]b enzimi dazol - 1 -yl ] -3 -pyri dyl ] ethanol ; l-[2-[l-(cyclobutylmethyl)-5-methyl-pyrazol-4-yl]-6-[5-[(6-m ethylpyridazin-3- yl)ami no]b enzimi dazol - 1 -yl ] -3 -pyri dyl ] ethanol ; or a pharmaceutically acceptable salt thereof.

68. A compound according to any one of embodiments 1 to 67 selected from l-[3-(l-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino]be nzimidazol-l-yl]-2-pyridyl]-5- methyl-pyrazole-3 -carbonitrile; l-[3-(l-hydroxyethyl)-6-[5-(6-methylpyridazin-3-yl)oxybenzim idazol-l-yl]-2-pyridyl]-5-methyl- pyrazole-3 -carbonitrile; l-[3-(l-hydroxyethyl)-6-[5-[(2-methylpyrimidin-5-yl)amino]be nzimidazol-l-yl]-2-pyridyl]-5- methyl-pyrazole-3 -carbonitrile; l-[3-(l-hydroxyethyl)-6-[5-[(6-methoxypyridazin-3-yl)amino]b enzimidazol-l-yl]-2-pyridyl]-5- methyl-pyrazole-3 -carbonitrile; l-[3-(l-hydroxyethyl)-6-[5-(pyridazin-3-ylamino)benzimidazol -l-yl]-2-pyridyl]-5-methyl- pyrazole-3 -carbonitrile; l-[6-[5-[[6-(difluoromethyl)pyridazin-3-yl]amino]benzimidazo l-l-yl]-3-(l-hydroxyethyl)-2- pyridyl]-5-methyl-pyrazole-3-carbonitrile; l-[6-[6-fluoro-5-[(6-methylpyridazin-3-yl)amino]benzimidazol -l-yl]-3-(l-hydroxyethyl)-2- pyridyl]-5-methyl-pyrazole-3-carbonitrile;

1-[6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-l-yl] -2-[3-(trifluoromethyl)-4,5,6,7- tetrahydropyrazolo[4,3-c]pyridin-l-yl]-3-pyridyl]ethanol;

2-[3-(l-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino ]benzimidazol-l-yl]-2-pyridyl]-5- methyl-pyrazole-3 -carbonitrile; rac-(3R)-l-[3-(l-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl )amino]benzimidazol-l-yl]-2- pyridyl]pyrrolidine-3-carbonitrile; l-[2-(3,5-dimethylpyrazol-l-yl)-6-[5-[(6-methylpyridazin-3-y l)amino]benzimidazol-l-yl]-3- pyridyl] ethanol;

5-methyl-l-[6-[5-[(6-methylpyridazin-3-yl)amino]benzimida zol-l-yl]-3-[rac-(lR)-l- hydroxyethyl]-2-pyridyl]pyrazole-3-carbonitrile;

5-methyl-l-[6-[5-[(6-methylpyridazin-3-yl)amino]benzimida zol-l-yl]-3-[rac-(lS)-l- hydroxyethyl]-2-pyridyl]pyrazole-3-carbonitrile; l-[3-(l-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino]be nzimidazol-l-yl]-2- pyridyl]pyrazole-3-carbonitrile; 5-[3-(l-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino]be nzimidazol-l-yl]-2- pyridyl]pyridine-3 -carbonitrile; l-[3-(l-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino]be nzimidazol-l-yl]-2-pyridyl]-3- methyl-pyrrolidine-3-carbonitrile; l-[6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-l-yl]-2- [2-methyl-5- (trifluoromethyl)pyrazol -3 -yl ] -3 -pyri dyl ] ethanol ;

3-(l-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino]be nzimidazol-l-yl]-N-(2,2,2- trifluoroethyl)pyridine-2-carboxamide; l-[6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-l-yl]-2- [rac-(3aR,6aS)-2,3,3a,5,6,6a- hexahy dro- 1 H-pyrrolo [ 3 ,2-b ] pyrrol -4-yl ] -3 -pyri dyl ] ethanol ; l-[2-[3-(difluoromethyl)-5-methyl-pyrazol-l-yl]-6-[5-[(6-met hylpyridazin-3- yl)ami no]b enzimi dazol - 1 -yl ] -3 -pyri dyl ] ethanol ; l-[2-(3-ethoxy-5-methyl-pyrazol-l-yl)-6-[5-[(6-methylpyridaz in-3-yl)amino]benzimidazol-l-yl]-

3-pyridyl]ethanol;

4-[3-(l-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino ]benzimidazol-l-yl]-2-pyridyl]-l- (2,2,2-trifluoroethyl)piperazin-2-one; formic acid;l-[[3-(l-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)am ino]benzimidazol-l-yl]-2- pyri dyl ] oxym ethyl ] cy cl opropanecarb onitril e ; l-[6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-l-yl]-2- [3-methyl-l -(2,2,2- trifluoroethyl)pyrazol-4-yl]-3-pyridyl]ethanol; l-[2-(5-methyl-3-methylsulfonyl-pyrazol-l-yl)-6-[5-[(6-methy lpyridazin-3- yl)ami no]b enzimi dazol - 1 -yl ] -3 -pyri dyl ] ethanol ;

5-methyl-l-[6-[5-[(6-methylpyridazin-3-yl)amino]benzimida zol-l-yl]-3-(2,2,2-trifluoro-l- hydroxy-ethyl)-2-pyridyl]pyrazole-3-carbonitrile; l-[2-[l-(difluoromethyl)-3-methyl-pyrazol-4-yl]-6-[5-[(6-met hylpyridazin-3- yl)ami no]b enzimi dazol - 1 -yl ] -3 -pyri dyl ] ethanol ; [2-(3-methoxy-5-methyl-pyrazol-l-yl)-6-[5-[(6-methylpyridazi n-3-yl)amino]benzimidazol-l-yl]- 3 -pyri dyl] methanol ; l-[3-(l-hydroxyethyl)-6-[5-[(4-methoxypyridazin-3-yl)amino]b enzimidazol-l-yl]-2-pyridyl]-5- methyl-pyrazole-3 -carbonitrile; l-[2-[2-(difluoromethoxy)-5-methyl-4-pyridyl]-6-[5-[(6-methy lpyridazin-3- yl)ami no]b enzimi dazol - 1 -yl ] -3 -pyri dyl ] ethanol ; l-[3-(l-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino]be nzimidazol-l-yl]-2-pyridyl]-4- methyl-pyrazole-3 -carbonitrile; l-[6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-l-yl]-2- [5-methyl-3-(trifluoromethyl)-6,7- dihydro-4H-pyrazol o [4, 3 -c] pyri din- 1 -yl ] -3 -pyri dyl ] ethanol ; l-[3-(l-hydroxyethyl)-6-[5-[[6-[(3-methoxyazetidin-l-yl)meth yl]pyridazin-3- yl]amino]benzimidazol-l-yl]-2-pyridyl]-5-methyl-pyrazole-3-c arbonitrile; l-[6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-l-yl]-2- [5-(oxetan-3-yl)-3- (trifluoromethyl)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-l-yl ]-3-pyridyl]ethanol; l-[3-(l-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino]be nzimidazol-l-yl]-2-pyridyl]-3- methyl-pyrazole-4-carbonitrile; l-[3-(l-hydroxyethyl)-6-[6-methoxy-5-[(6-methylpyridazin-3-y l)amino]benzimidazol-l-yl]-2- pyridyl]-5-methyl-pyrazole-3-carbonitrile; l-[3-(l-hydroxyethyl)-6-[6-(2-methoxyethoxy)-5-[(6-methylpyr idazin-3-yl)amino]benzimidazol- l-yl]-2-pyridyl]-5-methyl-pyrazole-3-carbonitrile; l-[6-[6-[2-(dimethylamino)ethoxy]-5-[(6-methylpyridazin-3-yl )amino]benzimidazol-l-yl]-3-(l- hydroxyethyl)-2-pyridyl]-5-methyl-pyrazole-3-carbonitrile; l-[3-(l-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino]-6 -pyrrolidin-3-yloxy-benzimidazol- l-yl]-2-pyridyl]-5-methyl-pyrazole-3-carbonitrile; l-[3-(l-hydroxyethyl)-6-[5-[[6-(2-methoxyethoxy)pyridazin-3- yl]amino]benzimidazol-l-yl]-2- pyridyl]-5-methyl-pyrazole-3-carbonitrile; l-[6-[5-[[6-(2,2-difluoroethoxy)pyridazin-3-yl]amino]benzimi dazol-l-yl]-3-(l-hydroxyethyl)-2- pyridyl]-5-methyl-pyrazole-3-carbonitrile; l-[6-[5-[[6-(difluoromethoxy)pyridazin-3-yl]amino]benzimidaz ol-l-yl]-3-(l-hydroxyethyl)-2- pyridyl]-5-methyl-pyrazole-3-carbonitrile; l-[3-(2,2-difluoro-l-hydroxy-ethyl)-6-[5-[(6-methylpyridazin -3-yl)amino]benzimidazol-l-yl]-2- pyridyl]-5-methyl-pyrazole-3-carbonitrile; l-[3-(l-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino]be nzimidazol-l-yl]pyri din-2 -yl]- 4,5,6,7-tetrahydropyrazolo[4,3-c]pyridine-3-carbonitrile; l-[6-[5-[[6-[2-(l,l-diketo-l,4-thiazinan-4-yl)ethoxy]pyridaz in-3-yl]amino]benzimidazol-l-yl]-3- (l-hydroxyethyl)-2-pyridyl]-5-methyl-pyrazole-3-carbonitrile ; l-[3-(l-hydroxyethyl)-6-[5-[[6-(oxetan-3-yloxy)pyridazin-3-y l]amino]benzimidazol-l-yl]-2- pyridyl]-5-methyl-pyrazole-3-carbonitrile; l-[2-(3-methoxy-5-methyl-pyrazol-l-yl)-6-[5-[(6-methylpyrida zin-3-yl)amino]benzimidazol-l- yl]-3-pyridyl]ethanol;

3-[[l-[6-(3-cyano-5-methyl-pyrazol-l-yl)-5-(l-hydroxyethy l)-2-pyridyl]benzimidazol-5- yl]amino]-N,N,6-trimethyl-pyridazine-4-carboxamide; l-[3-(l-hydroxyethyl)-6-[5-[[6-(oxetan-3-yl)pyridazin-3-yl]a mino]benzimidazol-l-yl]-2- pyridyl]-5-methyl-pyrazole-3-carbonitrile;

(lS)-l-[2-[3-(difluoromethyl)-5-methyl-pyrazol-l-yl]-6-[5 -[(6-methylpyridazin-3- yl)ami no]b enzimi dazol - 1 -yl ] -3 -pyri dyl ] ethanol ;

(lR)-l-[2-[3-(difluoromethyl)-5-methyl-pyrazol-l-yl]-6-[5 -[(6-methylpyridazin-3- yl)ami no]b enzimi dazol - 1 -yl ] -3 -pyri dyl ] ethanol ; l-[2-[5-(difluoromethyl)-3-methyl-pyrazol-l-yl]-6-[5-[(6-met hylpyridazin-3- yl)ami no]b enzimi dazol - 1 -yl ] -3 -pyri dyl ] ethanol ; l-[3-(l-hydroxy-2-methoxy-ethyl)-6-[5-[(6-methylpyridazin-3- yl)amino]benzimidazol-l-yl]-2- pyridyl]-5-methyl-pyrazole-3-carbonitrile; l-[6-[6-fluoro-5-[(6-methylpyridazin-3-yl)amino]benzimidazol -l-yl]-3-[(lS)-l-hydroxyethyl]-2- pyridyl]-5-methyl-pyrazole-3-carbonitrile; l-[6-[6-fluoro-5-[(6-methylpyridazin-3-yl)amino]benzimidazol -l-yl]-3-[(lR)-l-hydroxyethyl]-2- pyridyl]-5-methyl-pyrazole-3-carbonitrile; l-[6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-l-yl]-2- [5-methyl-l -(2,2,2- trifluoroethyl)pyrazol-4-yl]-3-pyridyl]ethanol; l-[6-[5-[(6-chloro-4-methoxy-pyridazin-3-yl)amino]benzimidaz ol-l-yl]-3-(l-hydroxyethyl)-2- pyridyl]-5-methyl-pyrazole-3-carbonitrile; rac-(3R,5S)-l-[3-(l-hydroxyethyl)-6-[5-[(6-methylpyridazin-3 -yl)amino]benzimidazol-l-yl]-2- pyridyl]-5-methyl-pyrrolidine-3-carbonitrile;

5-[3-(l-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino ]benzimidazol-l-yl]-2-pyridyl]-2- methyl-pyrazole-3 -carbonitrile; l-[2-[3,5-bis(difluoromethyl)pyrazol-l-yl]-6-[5-[(6-methylpy ridazin-3-yl)amino]benzimidazol-

1 -yl ] Pyri din-3 -yl ] ethanol ; l-[3-(l-hydroxyethyl)-6-[5-[[6-(trifluoromethyl)pyridazin-3- yl]amino]benzimidazol-l-yl]-2- pyridyl]-5-methyl-pyrazole-3-carbonitrile; l-[2-[2-ethyl-5-(trifluoromethyl)pyrazol-3-yl]-6-[5-[(6-meth ylpyridazin-3- yl)ami no]b enzimi dazol - 1 -yl ] -3 -pyri dyl ] ethanol ; rac-(lS)-l-[6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol -l-yl]-2-[3-methyl-l -(2,2,2- trifluoroethyl)pyrazol-4-yl]-3-pyridyl]ethanol; rac-(lR)-l-[6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol -l-yl]-2-[3-methyl-l -(2,2,2- trifluoroethyl)pyrazol-4-yl]-3-pyridyl]ethanol; l-[2-(l-ethyl-3-methyl-pyrazol-4-yl)-6-[5-[(6-methylpyridazi n-3-yl)amino]benzimidazol-l-yl]-3- pyri dyl] ethanol; l-[2-[l-(2-methoxyethyl)-3-methyl-pyrazol-4-yl]-6-[5-[(6-met hylpyridazin-3- yl)ami no]b enzimi dazol - 1 -yl ] -3 -pyri dyl ] ethanol ; l-[2-[l-(cyclopropylmethyl)-3-methyl-pyrazol-4-yl]-6-[5-[(6- methylpyridazin-3- yl)ami no]b enzimi dazol - 1 -yl ] -3 -pyri dyl ] ethanol ;

5-methyl-l-[3-methylol-6-[5-[(6-methylpyridazin-3-yl)amin o]benzimidazol-l-yl]-2- pyridyl]pyrazole-3-carbonitrile; l-[2-(l-ethyl-5-methyl-pyrazol-4-yl)-6-[5-[(6-methylpyridazi n-3-yl)amino]benzimidazol-l-yl]-3- pyri dyl] ethanol; l-[2-[l-(cyclopropylmethyl)-5-methyl-pyrazol-4-yl]-6-[5-[(6- methylpyridazin-3- yl)ami no]b enzimi dazol - 1 -yl ] -3 -pyri dyl ] ethanol ; l-[2-[l-(cyclobutylmethyl)-3-methyl-pyrazol-4-yl]-6-[5-[(6-m ethylpyridazin-3- yl)ami no]b enzimi dazol - 1 -yl ] -3 -pyri dyl ] ethanol ; l-[2-[l-(cyclobutylmethyl)-5-methyl-pyrazol-4-yl]-6-[5-[(6-m ethylpyridazin-3- yl)ami no]b enzimi dazol - 1 -yl ] -3 -pyri dyl ] ethanol ; or a pharmaceutically acceptable salt thereof.

69. A compound according to any one of embodiments 1 to 68, selected from l-[3-(l-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino]-6 -(trifluoromethyl)benzimidazol-l- yl]-2-pyridyl]-5-methyl-pyrazole-3-carbonitrile; l-[3-[(lS)-l-hydroxyethyl]-6-[5-[(6-methylpyridazin-3-yl)ami no]benzimidazol-l-yl]-2-pyridyl]- 5-methyl-pyrazole-3-carboximidic acid methyl ester; l-[2-[l-(2,2-difluorocyclopropyl)-3-methyl-pyrazol-4-yl]-6-[ 5-[(6-methylpyridazin-3- yl)ami no]b enzimi dazol - 1 -yl ] -3 -pyri dyl ] ethanol ; l-[2-[l-(2-methoxypropyl)-3-methyl-pyrazol-4-yl]-6-[5-[(6-me thylpyridazin-3- yl)ami no]b enzimi dazol - 1 -yl ] -3 -pyri dyl ] ethanol ; l-[2-[l-(2-methoxypropyl)-5-methyl-pyrazol-4-yl]-6-[5-[(6-me thylpyridazin-3- yl)ami no]b enzimi dazol - 1 -yl ] -3 -pyri dyl ] ethanol ; l-[3-[(lS)-l-hydroxyethyl]-6-[6-[(6-methylpyridazin-3-yl)ami no]benzimidazol-l-yl]-2-pyridyl]- 5-methyl-pyrazole-3-carbonitrile; l-[2-[l-(2,2-difluoropropyl)-3-methyl-pyrazol-4-yl]-6-[5-[(6 -methylpyridazin-3- yl)ami no]b enzimi dazol - 1 -yl ] -3 -pyri dyl ] ethanol ; l-[3-(l-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino]-6 -(oxetan-3-yloxy)benzimidazol-l- yl]-2-pyridyl]-5-methyl-pyrazole-3-carbonitrile; l-[2-(2-ethyl-5-methyl-4-pyridyl)-6-[5-[(6-methylpyridazin-3 -yl)amino]benzimidazol-l-yl]-3- pyri dyl] ethanol; l-[2-[l-(2,2-difluoropropyl)-5-methyl-pyrazol-4-yl]-6-[5-[(6 -methylpyridazin-3- yl)ami no]b enzimi dazol - 1 -yl ] -3 -pyri dyl ] ethanol ; l-[2-(2-methoxy-5-methyl-4-pyridyl)-6-[5-[(6-methylpyridazin -3-yl)amino]benzimidazol-l-yl]- 3-pyridyl]ethanol;

(lS)-l-[2-[3,5-bis(difluoromethyl)pyrazol-l-yl]-6-[5-[(6- methylpyridazin-3- yl)ami no]b enzimi dazol - 1 -yl ] -3 -pyri dyl ] ethanol ;

(lR)-l-[2-[3,5-bis(difluoromethyl)pyrazol-l-yl]-6-[5-[(6- methylpyridazin-3- yl)ami no]b enzimi dazol - 1 -yl ] -3 -pyri dyl ] ethanol ; l-[2-(2-cyclopropyl-5-methyl-4-pyridyl)-6-[5-[(6-methylpyrid azin-3-yl)amino]benzimidazol-l- yl]-3-pyridyl]ethanol; l-[2-[3-(difluoromethoxy)-5-methyl-pyrazol-l-yl]-6-[5-[(6-me thylpyridazin-3- yl)ami no]b enzimi dazol - 1 -yl ] -3 -pyri dyl ] ethanol ; l-[3-(l-hydroxyethyl)-6-[6-[(6-methylpyridazin-3-yl)amino]be nzimidazol-l-yl]-2-pyridyl]-5- methyl-6,7-dihydro-4~{H}-pyrazolo[4,3-c]pyridine-3-carbonitr ile; l-[3-(l-hydroxyethyl)-6-[5-[(6-methyl-4-methylsulfonyl-pyrid azin-3-yl)amino]benzimidazol-l- yl]-2-pyridyl]-5-methyl-pyrazole-3-carbonitrile; l-[3-(l-hydroxyethyl)-6-[5-[[6-[2-[2-[2-[2-[2-[2-(2- m ethoxy ethoxy)ethoxy] ethoxy] ethoxy] ethoxy] ethoxy] ethoxy]pyridazin-3 - yl]amino]benzimidazol-l-yl]-2-pyridyl]-5-methyl-pyrazole-3-c arbonitrile; l-[3-(l-hydroxyethyl)-6-[6-[(6-methyl-3-pyridyl)amino]-5-(2- morpholinoethoxy)benzimidazol- l-yl]-2-pyridyl]-5-methyl-pyrazole-3-carbonitrile; l-[3-(l-hydroxyethyl)-6-[6-(2-oxa-5-azaspiro[3.4]octan-5-yl) benzimidazol-l-yl]-2-pyridyl]-5- methyl-pyrazole-3 -carbonitrile; l-[3-(l-hydroxyethyl)-6-[5-(2-oxa-5-azaspiro[3.4]octan-5-yl) benzimidazol-l-yl]-2-pyridyl]-5- methyl-pyrazole-3 -carbonitrile; l-[3-(l-hydroxyethyl)-6-[5-[(6-methyl-3-pyridyl)amino]-6-(2- morpholinoethoxy)benzimidazol- l-yl]-2-pyridyl]-5-methyl-pyrazole-3-carbonitrile; l-[2-[3-(difluoromethyl)pyrrolidin-l-yl]-6-[5-[(6-methylpyri dazin-3-yl)amino]benzimidazol-l- yl]-3-pyridyl]ethanol; l-[2-(2,2-difluoro-5-azaspiro[2.4]heptan-5-yl)-6-[5-[(6-meth ylpyridazin-3- yl)ami no]b enzimi dazol - 1 -yl ] -3 -pyri dyl ] ethanol ;

(lS)-l-[2-[3-(difluoromethyl)-5-methyl-pyrazol-l-yl]-6-[6 -fluoro-5-[(6-methylpyridazin-3- yl)ami no]b enzimi dazol - 1 -yl ] -3 -pyri dyl ] ethanol ; l-[6-[6-fluoro-5-[(6-methylpyridazin-3-yl)amino]benzimidazol -l-yl]-2-[3-methyl-l -(2,2,2- trifluoroethyl)pyrazol-4-yl]-3-pyridyl]ethanol;

5-(difluoromethyl)-2-[3-(l-hydroxyethyl)-6-[5-[(6-methylp yridazin-3-yl)amino]benzimidazol-l- yl]-2-pyridyl]pyrazole-3-carbonitrile; l-[3-(l-hydroxyethyl)-6-[5-[[6-[l-(oxetan-3-yl)pyrrolidin-2- yl]pyridazin-3- yl]amino]benzimidazol-l-yl]-2-pyridyl]-5-methyl-pyrazole-3-c arbonitrile;

7,7-difluoro-l-[3-(l-hydroxyethyl)-6-[5-[(6-methylpyridaz in-3-yl)amino]benzimidazol-l-yl]-2- pyridyl]-5,6-dihydro-4~{H}-pyrazolo[4,3-c]pyridine-3-carboni trile;

5-(difluoromethyl)-l-[3-(l-hydroxyethyl)-6-[5-[(6-methylp yridazin-3-yl)amino]benzimidazol-l- yl]-2-pyridyl]pyrazole-3-carbonitrile;

(lS)-l-[2-[3-(difluoromethyl)-5-methyl-pyrazol-l-yl]-6-[6 -fluoro-5-(pyridazin-3- yl amino)b enzimi dazol - 1 -yl ] -3 -pyri dyl ] ethanol ; l-[6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-l-yl]-2- [5-methyl-2-(2,2,2- trifluoroethyl)tri azol -4-yl] -3 -pyri dyl ] ethanol ; l-[3-(l-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino]be nzimidazol-l-yl]-2-pyridyl]-4,5- dimethyl-pyrazole-3-carbonitrile; l-[3-(l-hydroxyethyl)-6-[5-[(4-methyl-2,3-dihydropyridazino[ 4,5-b][l,4]oxazin-8- yl)amino]benzimidazol-l-yl]-2-pyridyl]-5-methyl-pyrazole-3-c arbonitrile; l-[6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-l-yl]-2- [5-methyl-l -(2,2,2- trifluoroethyl)tri azol -4-yl] -3 -pyri dyl ] ethanol ;

1 ■[ 1 -[6-(3-cyano-5-methyl-pyrazol- 1 -yl)-5 -( 1 -hydroxyethyl)-2-pyridyl]benzimidazol-5-yl]-N,N- dimethyl-pyrrolidine-2-carboxamide; l-[2-[l-(2,2-difluoroethyl)-3-methyl-pyrazol-4-yl]-6-[5-[(6- methylpyridazin-3- yl)ami no]b enzimi dazol - 1 -yl ] -3 -pyri dyl ] ethanol ; l-[6-[5-fluoro-6-[(6-methylpyridazin-3-yl)amino]benzimidazol -l-yl]-3-(hydroxymethyl)-2- pyridyl]-5-methyl-pyrazole-3-carbonitrile;

[6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-l -yl]-2-[3-methyl-l -(2,2,2- trifluoroethyl)pyrazol-4-yl]-3-pyridyl]methanol;

[6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-l -yl]-2-[5-methyl-l -(2,2,2- trifluoroethyl)pyrazol-4-yl]-3-pyridyl]methanol;

[2-[3-(difluoromethyl)-5-methyl-pyrazol-l-yl]-6-[5-(7,8-d ihydro-5H-pyrano[4,3-c]pyridazin-3- yl amino)b enzimi dazol - 1 -yl ] -3 -pyri dyl ] methanol ;

[6-[5-[(4aS,7aR)-4-methyl-2,3,4a,5,7,7a-hexahydropyrrolo[ 3,4-b][l,4]oxazin-6-yl]benzimidazol- l-yl]-2-[3-(difluoromethyl)-5-methyl-pyrazol-l-yl]-3-pyridyl ]methanol;

[2-[3-(difluoromethyl)-5-methyl-pyrazol-l-yl]-6-[6-fluoro -5-[(6-methylpyridazin-3- yl)amino]benzimidazol-l-yl]-3-pyridyl]methanol; l-[6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-l-yl]-2- [2-(trifluoromethyl)morpholin-4- yl]-3-pyridyl]ethanol;

3-[3-(l-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino ]benzimidazol-l-yl]-2-pyridyl]-3- azabicyclo[3.1.0]hexane- 1 -carbonitrile; l-[2-(5,5-difluoro-2-azabicyclo[2.2.1]heptan-2-yl)-6-[5-[(6- methylpyridazin-3- yl)ami no]b enzimi dazol - 1 -yl ] -3 -pyri dyl ] ethanol ; l-[2-[2-(difluoromethyl)morpholin-4-yl]-6-[5-[(6-methylpyrid azin-3-yl)amino]benzimidazol-l- yl]-3-pyridyl]ethanol; l-[2-(6,6-difluoro-2-azabicyclo[2.2.1]heptan-2-yl)-6-[5-[(6- methylpyridazin-3- yl)ami no]b enzimi dazol - 1 -yl ] -3 -pyri dyl ] ethanol ; l-[2-[7-(difluoromethyl)-5-azaspiro[2.4]heptan-5-yl]-6-[5-[( 6-methylpyridazin-3- yl)ami no]b enzimi dazol - 1 -yl ] -3 -pyri dyl ] ethanol ; l-[2-(6,6-difluoro-3-azabicyclo[3.2.0]heptan-3-yl)-6-[5-[(6- methylpyridazin-3- yl)ami no]b enzimi dazol - 1 -yl ] -3 -pyri dyl ] ethanol ;

N-[l-[6-(3-cyano-5-methyl-pyrazol-l-yl)-5-(l-hydroxyethyl )-2-pyridyl]benzimidazol-5- yl]cyclopropanecarboxamide;

N-[3-[6-(3-cyano-5-methyl-pyrazol-l-yl)-5-(l-hydroxyethyl )-2-pyridyl]benzimidazol-5- yl]cyclopropanecarboxamide; l-[2-(4,7-diazaspiro[2.5]octan-7-yl)-6-[5-[(6-methylpyridazi n-3-yl)amino]benzimidazol-l-yl]-3- pyri dyl] ethanol; l-[6-[5-[(3aS,6aS)-6-oxo-2,3,3a,4,5,6a-hexahydropyrrolo[2,3- c]pyrrol-l-yl]benzimidazol-l-yl]- 3-(l-hydroxyethyl)-2-pyridyl]-5-methyl-pyrazole-3-carbonitri le; l-[6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-l-yl]-2- [3-(trifluoromethyl)piperazin-l- yl]-3-pyridyl]ethanol; l-[6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-l-yl]-2- [5-methyl-2-(trifluoromethyl)-4- pyri dyl ] - 3 -pyri dyl ] ethanol ; l-[3-(l-hydroxyethyl)-6-[5-[(2-keto-l-methyl-3-pyridyl)amino ]benzimidazol-l-yl]-2-pyridyl]-5- methyl-pyrazole-3 -carbonitrile;

1 -[3-(l -hydroxyethyl)-6-[5-(3-methoxy-l -methyl -pyrazol -4-yl)benzimidazol-l -yl]-2-pyridyl]-5- methyl-pyrazole-3 -carbonitrile; l-[2-[2-(difluoromethyl)-5-methyl-4-pyridyl]-6-[5-[(6-methyl pyridazin-3- yl)ami no]b enzimi dazol - 1 -yl ] -3 -pyri dyl ] ethanol ; l-[3-(l-hydroxyethyl)-6-[6-(l -methyl -2-oxo-pyrimidin-4-yl)benzimidazol-l -yl]-2-pyridyl]-5- methyl-pyrazole-3 -carbonitrile; l-[2-[3-(difluoromethyl)-5-methyl-pyrazol-l-yl]-6-[6-fluoro- 5-[[6-(2-methyl-l,3-dioxolan-2- yl)pyridazin-3-yl]amino]benzimidazol-l-yl]-3-pyridyl]ethanol ; l-[3-(l-hydroxyethyl)-6-[5-(l -methyl -2-oxo-pyrimidin-4-yl)benzimidazol-l -yl]-2-pyridyl]-5- methyl-pyrazole-3 -carbonitrile; l-[3-(l-hydroxyethyl)-6-[6-(6-methylpyridazin-3-yl)benzimida zol-l-yl]-2-pyridyl]-5-methyl- pyrazole-3 -carbonitrile; l-[3-(l-hydroxyethyl)-6-[5-(6-methylpyridazin-3-yl)benzimida zol-l-yl]-2-pyridyl]-5-methyl- pyrazole-3 -carbonitrile; l-[6-[6-[(2S)-2-cyanopyrrolidin-l-yl]benzimidazol-l-yl]-3-(l -hydroxyethyl)-2-pyridyl]-5- methyl-pyrazole-3 -carbonitrile; l-[6-[5-[(2S)-2-cyanopyrrolidin-l-yl]benzimidazol-l-yl]-3-(l -hydroxyethyl)-2-pyridyl]-5- methyl-pyrazole-3 -carbonitrile; l-[6-[6-[(3aS,6aS)-6-oxo-2,3,3a,4,5,6a-hexahydropyrrolo[2,3- c]pyrrol-l-yl]benzimidazol-l-yl]-

3-(l-hydroxyethyl)-2-pyridyl]-5-methyl-pyrazole-3-carboni trile; l-[2-[3-(difluoromethyl)-5-methyl- 1,2, 4-tri azol- 1 -yl]-6-[5-[(6-methylpyridazin-3- yl)ami no]b enzimi dazol - 1 -yl ] -3 -pyri dyl ] ethanol ;

3-[[l-[6-[3-(difluoromethyl)-5-methyl-pyrazol-l-yl]-5-[(l ~{S})-l-hydroxyethyl]-2-pyridyl]-6- fluoro-benzimidazol-5-yl]amino]-~{N},~{N},6-trimethyl-pyrida zine-4-carboxamide; l-[2-[2-(difluoromethoxy)-5-methyl-4-pyridyl]-6-[6-fluoro-5- [(6-methylpyridazin-3- yl)ami no]b enzimi dazol - 1 -yl ] -3 -pyri dyl ] ethanol ; l-[6-[6-fluoro-5-[(6-methylpyridazin-3-yl)amino]benzimidazol -l-yl]-3-(hydroxymethyl)-2- pyridyl]-5-methyl-pyrazole-3-carbonitrile; 3-[[l-[6-[3,5-bis(difluoromethyl)pyrazol-l-yl]-5-(hydroxymet hyl)-2-pyridyl]benzimidazol-5- yl]amino]-N,N,6-trimethyl-pyridazine-4-carboxamide; l-[6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-l-yl]-2- [4-methyl-l -(2,2,2- trifluoroethyl)pyrazol -3 -yl ] -3 -pyri dyl ] ethanol ; l-[2-[3-methyl-l-(2,2,2-trifluoroethyl)pyrazol-4-yl]-6-[5-[6 -(morpholinomethyl)pyridazin-3- yl ] oxyb enzimi dazol - 1 -yl] -3 -pyri dyl ] ethanol ; l-[6-[5-(6-methylpyridazin-3-yl)oxybenzimidazol-l-yl]-2-[3-m ethyl-l -(2,2,2- trifluoroethyl)pyrazol-4-yl]-3-pyridyl]ethanol; l-[6-[5-[6-[(4-methylpiperazin-l-yl)methyl]pyridazin-3-yl]ox ybenzimidazol-l-yl]-2-[3-methyl- l-(2,2,2-trifluoroethyl)pyrazol-4-yl]-3-pyridyl]ethanol; l-[2-[3-(difluoromethoxy)-5-methyl-pyrazol-l-yl]-6-[6-[(6-me thylpyridazin-3-yl)amino]-5- (ox etan-3 -yl oxy)b enzimi dazol - 1 -yl ] -3 -pyri dyl ] ethanol ; l-[2-(3-chloro-5-methyl-pyrazol-l-yl)-6-[5-fluoro-6-[(6-meth ylpyridazin-3- yl)ami no]b enzimi dazol - 1 -yl ] -3 -pyri dyl ] ethanol ; l-[2-(3-chloro-5-methyl-pyrazol-l-yl)-6-[6-fluoro-5-[(6-meth ylpyridazin-3- yl)ami no]b enzimi dazol - 1 -yl ] -3 -pyri dyl ] ethanol ; l-[2-[l-(cyclopropylmethyl)-3-methyl-pyrazol-4-yl]-6-[6-fluo ro-5-[(6-methylpyridazin-3- yl)ami no]b enzimi dazol - 1 -yl ] -3 -pyri dyl ] ethanol ; l-[2-[3-(difluoromethoxy)-5-methyl-pyrazol-l-yl]-6-[5-[(6-me thylpyridazin-3-yl)amino]-6- (ox etan-3 -yl oxy)b enzimi dazol - 1 -yl ] -3 -pyri dyl ] ethanol ;

N-[ 1 - [5 -( 1 -hydroxyethyl)-6-[3 -methyl- 1 -(2,2,2-trifluoroethyl)pyrazol-4-yl]-2- pyridyl]benzimidazol-5-yl]-2-(l-piperidyl)acetamide;

6-[3-(l-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino ]benzimidazol-l-yl]-2-pyridyl]-6- azaspiro[3.4]octane-8-carbonitrile;

4-[3-(l-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino ]benzimidazol-l-yl]-2- pyridyl]morpholine-2-carbonitrile; N-[l-[6-[3-(difluoromethyl)-5-methyl-pyrazol-l-yl]-5-(l-hydr oxyethyl)-2-pyridyl]-6-fluoro- benzimidazol-5-yl]cyclopropanecarboxamide; l-[6-[6-(2,3-difluoro-4-methyl-anilino)-5-fluoro-benzimidazo l-l-yl]-2-[3-(difluoromethyl)-5- m ethyl -pyrazol - 1 -yl] -3 -pyri dyl ] ethanol ; l-[2-[l-(difluoromethyl)-4-methyl-pyrazol-3-yl]-6-[5-[(6-met hylpyridazin-3- yl)ami no]b enzimi dazol - 1 -yl ] -3 -pyri dyl ] ethanol ; l-[2-[3-(difluoromethyl)-5-methyl-pyrazol-l-yl]-6-[5-fluoro- 6-(2,3,4- trifluoroanilino)benzimidazol-l-yl]-3-pyridyl]ethanol;

1-[3-(l-hydroxyethyl)-6-[6-(6-methyl-7-oxo-5H-pyrrolo[3,4 -b]pyri din-2 -yl)benzimidazol-l-yl]-

2-pyridyl]-5-methyl-pyrazole-3-carbonitrile;

1-[3-(l-hydroxyethyl)-6-[5-(6-methyl-7-oxo-5H-pyrrolo[3,4 -b]pyri din-2 -yl)benzimidazol-l-yl]-

2-pyridyl]-5-methyl-pyrazole-3-carbonitrile; l-[2-[3-(difluoromethoxy)-5-methylpyrazol-l-yl]-6-[5-[[6-(di fluoromethyl)pyridazin-3- yl]amino]benzimidazol-l-yl]pyridin-3-yl]ethanol; l-[2-[3-(difluoromethyl)-5-ethyl-pyrazol-l-yl]-6-[6-[(6-meth ylpyridazin-3- yl)ami no]b enzimi dazol - 1 -yl ] -3 -pyri dyl ] ethanol ; l-[2-[3-(difluoromethyl)-4,5-dimethyl-pyrazol-l-yl]-6-[5-[(6 -methylpyridazin-3- yl)ami no]b enzimi dazol - 1 -yl ] -3 -pyri dyl ] ethanol ; l-[2-[3-(difluoromethyl)-5-ethyl-pyrazol-l-yl]-6-[5-[(6-meth ylpyridazin-3- yl)ami no]b enzimi dazol - 1 -yl ] -3 -pyri dyl ] ethanol ; l-[6-[6-[(6-chloropyridazin-3-yl)amino]-5-fluoro-benzimidazo l-l-yl]-2-[3-(difluoromethyl)-5- m ethyl -pyrazol - 1 -yl] -3 -pyri dyl ] ethanol ; l-[6-[5-[(6-chloropyridazin-3-yl)amino]-6-fluoro-benzimidazo l-l-yl]-2-[3-(difluoromethyl)-5- m ethyl -pyrazol - 1 -yl] -3 -pyri dyl ] ethanol ;

(lS)-l-[2-[3-(difluoromethoxy)-5-methyl-pyrazol-l-yl]-6-[ 6-fluoro-5-(pyridazin-3- yl amino)b enzimi dazol - 1 -yl ] -3 -pyri dyl ] ethanol ; (lS)-l-[2-[3-(difluoromethoxy)-5-methyl-pyrazol-l-yl]-6-[6-f luoro-5-[(6-methylpyridazin-3- yl)ami no]b enzimi dazol - 1 -yl ] -3 -pyri dyl ] ethanol ;

(lR)-l-[2-[3-(difluoromethoxy)-5-methyl-pyrazol-l-yl]-6-[ 6-fluoro-5-[(6-methylpyridazin-3- yl)ami no]b enzimi dazol - 1 -yl ] -3 -pyri dyl ] ethanol ;

1-[6-[5-fluoro-6-[(5-methyl-l, 3, 4-oxadiazol -2 -yl)amino]benzimidazol-l-yl]-3-(l -hydroxyethyl)-

2-pyridyl]-5-methyl-pyrazole-3-carbonitrile;

1 -[6-[6-fluoro-5-[(5-methyl-l, 3, 4-oxadiazol -2 -yl)amino]benzimidazol-l-yl]-3-(l -hydroxyethyl)-

2-pyridyl]-5-methyl-pyrazole-3-carbonitrile; l-[6-[6-fluoro-5-(2,3,4-trifluoroanilino)benzimidazol-l-yl]- 3-(l-hydroxyethyl)-2-pyridyl]-5- methyl-pyrazole-3 -carbonitrile; l-[6-[5-fluoro-6-(2,3,4-trifluoroanilino)benzimidazol-l-yl]- 3-(l-hydroxyethyl)-2-pyridyl]-5- methyl-pyrazole-3 -carbonitrile;

N-[l-[6-(3-cyano-5-methyl-pyrazol-l-yl)-5-(l-hydroxyethyl )-2-pyridyl]benzimidazol-5-yl]-l- fluoro-cyclopropanecarboxamide; l-[6-[6-(6,7-dihydro-5~{H}-cyclopenta[c]pyridazin-3-ylamino) -5-fluoro-benzimidazol-l-yl]-3- (l-hydroxyethyl)-2-pyridyl]-5-methyl-pyrazole-3-carbonitrile ; l-[6-[5-(6,7-dihydro-5~{H}-cyclopenta[c]pyridazin-3-ylamino) -6-fluoro-benzimidazol-l-yl]-3- (l-hydroxyethyl)-2-pyridyl]-5-methyl-pyrazole-3-carbonitrile ;

(lS)-l-[2-[3-(difluoromethoxy)-5-methyl-pyrazol-l-yl]-6-[ 5-[(6-methylpyridazin-3-yl)amino]-6- (ox etan-3 -yl oxy)b enzimi dazol - 1 -yl ] -3 -pyri dyl ] ethanol ;

(lR)-l-[2-[3-(difluoromethoxy)-5-methyl-pyrazol-l-yl]-6-[ 5-[(6-methylpyridazin-3-yl)amino]-6- (ox etan-3 -yl oxy)b enzimi dazol - 1 -yl ] -3 -pyri dyl ] ethanol ;

1-[6-[6-fluoro-5-[(5-methyl-l, 3, 4-thiadiazol-2-yl)amino]benzimidazol-l-yl]-3-(l -hydroxyethyl)-

2-pyridyl]-5-methyl-pyrazole-3-carbonitrile;

3-fluoro-4-[3-(l-hydroxyethyl)-6-[5-[(6-methylpyridazin-3 -yl)amino]benzimidazol-l-yl]-2- pyridyl]-l-(2,2,2-trifluoroethyl)pyridin-2-one; l-[2-[3,5-bis(difluoromethyl)pyrazol-l-yl]-6-[6-fluoro-5-[(6 -methylpyridazin-3- yl)ami no]b enzimi dazol - 1 -yl ] -3 -pyri dyl ] ethanol ; l-[6-[6-(difluoromethoxy)-5-[(6-methylpyridazin-3-yl)amino]b enzimidazol-l-yl]-3-(l- hydroxyethyl)-2-pyridyl]-5-methyl-pyrazole-3-carbonitrile; l-[6-[6-fluoro-5-[(5-fluoro-6-methyl-3-pyridyl)amino]benzimi dazol-l-yl]-3-(l-hydroxyethyl)-2- pyridyl]-5-methyl-pyrazole-3-carbonitrile; l-[6-[5-[[5-(azetidin-l-yl)pyridazin-3-yl]amino]-6-fluoro-be nzimidazol-l-yl]-2-[3- (difluoromethyl)-5-methyl-pyrazol-l-yl]-3-pyridyl]ethanol; l-[6-[6-fluoro-5-[(5-fluoro-6-methyl-3-pyridyl)amino]benzimi dazol-l-yl]-3-[(lS)-l- hydroxyethyl]-2-pyridyl]-5-methyl-pyrazole-3-carbonitrile; l-[3-(l-hydroxyethyl)-6-[5-[2-(2-oxopyrrolidin-l-yl)oxazol-5 -yl]benzimidazol-l-yl]-2-pyridyl]- 5-methyl-pyrazole-3-carbonitrile; l-[2-(4,4-difluoropyrrolidin-3-yl)oxy-6-[5-[(6-methylpyridaz in-3-yl)amino]benzimidazol-l-yl]- 3-pyridyl]ethanol; l-[6-[5-(7,8-dihydro-5~{H}-pyrano[4,3-c]pyridazin-3-ylamino) -6-methoxy-benzimidazol-l-yl]- 3-(l-hydroxyethyl)-2-pyridyl]-5-methyl-pyrazole-3-carbonitri le; l-[3-(l-hydroxyethyl)-6-[6-[2-(2-oxopyrrolidin-l-yl)oxazol-5 -yl]benzimidazol-l-yl]-2-pyridyl]- 5-methyl-pyrazole-3-carbonitrile; l-[2-[6-(difluoromethoxy)-3-methyl-pyridazin-4-yl]-6-[5-[(6- methylpyridazin-3- yl)ami no]b enzimi dazol - 1 -yl ] -3 -pyri dyl ] ethanol ; l-[2-[3-(difluoromethyl)-5-methoxy-pyrazol-l-yl]-6-[6-[(6-me thylpyridazin-3- yl)amino]benzimidazol-l-yl]-3-pyridyl]ethanol; l-[2-[3-(difluoromethyl)-5-methoxy-pyrazol-l-yl]-6-[5-[(6-me thylpyridazin-3- yl)ami no]b enzimi dazol - 1 -yl ] -3 -pyri dyl ] ethanol ; l-[2-[l-(2,3-difluoropropyl)-3-methyl-pyrazol-4-yl]-6-[5-[(6 -methylpyridazin-3- yl)ami no]b enzimi dazol - 1 -yl ] -3 -pyri dyl ] ethanol ; (lS)-l-[2-[3-(difluoromethoxy)-5-methyl-pyrazol-l-yl]-6-[6-m ethoxy-5-[(2-methylpyrimidin-5- yl)ami no]b enzimi dazol - 1 -yl ] -3 -pyri dyl ] ethanol ; l-[6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-l-yl]-2- [2-methyl-5-(2,2,2-trifluoroethyl)- l,2,4-triazol-3-yl]-3-pyridyl]ethanol; l-[6-[6-(difluoromethoxy)-5-[(6-methylpyridazin-3-yl)amino]b enzimidazol-l-yl]-3-[(lS)-l- hydroxyethyl]-2-pyridyl]-5-methyl-pyrazole-3-carbonitrile; l-[6-[6-(difluoromethoxy)-5-[(6-methylpyridazin-3-yl)amino]b enzimidazol-l-yl]-3-[(lR)-l- hydroxyethyl]-2-pyridyl]-5-methyl-pyrazole-3-carbonitrile; l-[2-[3-(difluoromethoxy)-5-(difluoromethyl)pyrazol-l-yl]-6- [5-[(6-methylpyridazin-3- yl)ami no]b enzimi dazol - 1 -yl ] -3 -pyri dyl ] ethanol ; l-[2-[3-(difluoromethoxy)-5-(difluoromethyl)pyrazol-l-yl]-6- [6-[(6-methylpyridazin-3- yl)ami no]b enzimi dazol - 1 -yl ] -3 -pyri dyl ] ethanol ; l-[2-[3-(difluoromethoxy)-5-methyl-pyrazol-l-yl]-6-[6-[(6-me thylpyridazin-3-yl)amino]-5-

(ox etan-3 -ylmethyl)b enzimi dazol - 1 -yl ] -3 -pyri dyl ] ethanol ; and l-[2-[3-(difluoromethoxy)-5-methyl-pyrazol-l-yl]-6-[5-[(6-me thylpyridazin-3-yl)amino]-6- (ox etan-3 -ylmethyl)b enzimi dazol - 1 -yl ] -3 -pyri dyl ] ethanol ; or a pharmaceutically acceptable salt thereof.

70. A compound according to any one of embodiments 1 to 69, selected from l-[2-[l-(2,2-difluoropropyl)-3-methyl-pyrazol-4-yl]-6-[5-[(6 -methylpyridazin-3- yl)ami no]b enzimi dazol - 1 -yl ] -3 -pyri dyl ] ethanol ;

(lS)-l-[2-[3,5-bis(difhioromethyl)pyrazol-l-yl]-6-[5-[(6- methylpyridazin-3- yl)ami no]b enzimi dazol - 1 -yl ] -3 -pyri dyl ] ethanol ; l-[2-[3-(difluoromethoxy)-5-methyl-pyrazol-l-yl]-6-[5-[(6-me thylpyridazin-3- yl)ami no]b enzimi dazol - 1 -yl ] -3 -pyri dyl ] ethanol ;

(lS)-l-[2-[3-(difhroromethyl)-5-methyl-pyrazol-l-yl]-6-[6 -fluoro-5-[(6-methylpyridazin-3- yl)ami no]b enzimi dazol - 1 -yl ] -3 -pyri dyl ] ethanol ; l-[6-[6-fluoro-5-[(6-methylpyridazin-3-yl)amino]benzimidazol -l-yl]-2-[3-methyl-l -(2,2,2- trifluoroethyl)pyrazol-4-yl]-3-pyridyl]ethanol;

5-(difluoromethyl)-2-[3-(l-hydroxyethyl)-6-[5-[(6-methylp yridazin-3-yl)amino]benzimidazol-l- yl]-2-pyridyl]pyrazole-3-carbonitrile; l-[6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-l-yl]-2- [5-methyl-2-(2,2,2- trifluoroethyl)tri azol -4-yl] -3 -pyri dyl ] ethanol ; l-[3-(l-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino]be nzimidazol-l-yl]-2-pyridyl]-4,5- dimethyl-pyrazole-3-carbonitrile; l-[6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-l-yl]-2- [5-methyl-l -(2,2,2- trifluoroethyl)tri azol -4-yl] -3 -pyri dyl ] ethanol ; l-[2-[l-(2,2-difluoroethyl)-3-methyl-pyrazol-4-yl]-6-[5-[(6- methylpyridazin-3- yl)ami no]b enzimi dazol - 1 -yl ] -3 -pyri dyl ] ethanol ; l-[6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-l-yl]-2- [4-methyl-l -(2,2,2- trifluoroethyl)pyrazol -3 -yl ] -3 -pyri dyl ] ethanol ; l-[2-[l-(difluoromethyl)-4-methyl-pyrazol-3-yl]-6-[5-[(6-met hylpyridazin-3- yl)ami no]b enzimi dazol - 1 -yl ] -3 -pyri dyl ] ethanol ;

(lS)-l-[2-[3-(difluoromethoxy)-5-methyl-pyrazol-l-yl]-6-[ 6-fluoro-5-(pyridazin-3- yl amino)b enzimi dazol - 1 -yl ] -3 -pyri dyl ] ethanol ; and

(lS)-l-[2-[3-(difluoromethoxy)-5-methyl-pyrazol-l-yl]-6-[ 6-fluoro-5-[(6-methylpyridazin-3- yl)ami no]b enzimi dazol - 1 -yl ] -3 -pyri dyl ] ethanol ; or a pharmaceutically acceptable salt thereof.

70. A process for the preparation of a compound according to any one of embodiments 1 to 69, comprising one of the following steps:

(a) the reaction of a compound of formula (Bl) with a reducing agent;

(b) the reaction of a compound of formula (Cl) with a reducing agent; or

(c) the reaction of a compound (DI) with a compound of formula R ^c MgX, wherein Al, A2, A3, R ¹ , R ² , R ³ , R ⁴ and R ⁵ are as defined in any one of embodiments 1 to 65, is alkyl or cycloalkyl, R ^b is hydrogen or alkyl, R ^c is alkyl or cycloalkyl, and X is halogen.

71. A compound according to any one of embodiments 1 to 69 when manufactured according to a process of embodiment 70.

72. A compound of formula (I) according to any one of embodiments 1 to 69 or a pharmaceutically acceptable salt thereof, for use as therapeutically active substance.

73. A pharmaceutical composition comprising a compound of formula (I) according to any one of embodiments 1 to 69 or a pharmaceutically acceptable salt thereof, and a therapeutically inert carrier.

74. The use of a compound of formula (I) according to any one of embodiments 1 to 69 or a pharmaceutically acceptable salt thereof, for the treatment or prophylaxis of rheumatoid arthritis, juvenile rheumatoid arthritis, non-alcoholic steatohepatitis (NASH), primary sclerosing cholangitis, giant cell vasculitis, inflammatory bowel diseases (IBD), atherosclerosis, type 2 diabetes or glomerulonephritis.

75. The use of a compound of formula (I) according to any one of embodiments 1 to 69 or a pharmaceutically acceptable salt thereof, for the preparation of a medicament for the treatment or prophylaxis rheumatoid arthritis, juvenile rheumatoid arthritis, non-alcoholic steatohepatitis (NASH), primary sclerosing cholangitis, giant cell vasculitis, inflammatory bowel diseases (IBD), atherosclerosis, type 2 diabetes or glomerulonephritis.

76. A compound of formula (I) according to any one of embodiments 1 to 69 or a pharmaceutically acceptable salt thereof, for use in the treatment or prophylaxis of rheumatoid arthritis, juvenile rheumatoid arthritis, non-alcoholic steatohepatitis (NASH), primary sclerosing cholangitis, giant cell vasculitis, inflammatory bowel diseases (IBD), atherosclerosis, type 2 diabetes or glomerulonephritis.

77. A method for the treatment or prophylaxis of rheumatoid arthritis, juvenile rheumatoid arthritis, non-alcoholic steatohepatitis (NASH), primary sclerosing cholangitis, giant cell vasculitis, inflammatory bowel diseases (IBD), atherosclerosis, type 2 diabetes or glomerulonephritis, which method comprises administering an effective amount of a compound of formula (I) according to any one of embodiments 1 to 69 or a pharmaceutically acceptable salt thereof, to a patient in need thereof.