Title:
NEW CONJUGATES
Document Type and Number:
WIPO Patent Application WO/2022/193185
Kind Code:
A1
Abstract:
Provided are a conjugate formed between an anaesthetic compound and a peptide component of the amino acid sequence:W-Lys-X1-Ser-U-X2-Y, wherein:W, X1, U, X2 and Y are as defined in the description, as well as regioisomers, stereoisomers, and pharmaceutically-or cosmetically-acceptable salts of said conjugates, which conjugates are useful in the treatment of conditions characterised by inflammation and/or of pain. Preferred anaesthetics are local anaesthetics, such as procaine.
Inventors:
SAMUELSSON BENGT INGEMAR (SE)
JANSON JAN-CHRISTER (SE)
GU MING (CN)
SONG MAOQIAN (CN)
JANSON JAN-CHRISTER (SE)
GU MING (CN)
SONG MAOQIAN (CN)
Application Number:
PCT/CN2021/081361
Publication Date:
September 22, 2022
Filing Date:
March 17, 2021
Export Citation:
Assignee:
JIANGYIN USUN PHARMACEUTICAL CO LTD (CN)
International Classes:
A61K47/64; A61P17/00; A61P29/00; C07K2/00
Domestic Patent References:
| WO2020052677A1 | 2020-03-19 | |||
| WO2019007355A1 | 2019-01-10 |
Foreign References:
| CN109316602A | 2019-02-12 | |||
| EP2305307A1 | 2011-04-06 | |||
| US5616311A | 1997-04-01 | |||
| CN111712252A | 2020-09-25 | |||
| CN112236440A | 2021-01-15 | |||
| CN110312513A | 2019-10-08 |
Other References:
KANYALKAR, M. SRIVASTAVA, S. COUTINHO, E.: "Conformation of a model peptide of the tandem repeat decapeptide in mussel adhesive protein by NMR and MD simulations", BIOMATERIALS, ELSEVIER, AMSTERDAM, NL, vol. 23, no. 2, 1 January 2002 (2002-01-01), AMSTERDAM, NL , pages 389 - 396, XP004348044, ISSN: 0142-9612, DOI: 10.1016/S0142-9612(01)00117-X
CAROL M. TAYLOR, CLAUDETTE A. WEIR: "Synthesis of the Repeating Decapeptide Unit of Mefp1 in Orthogonally Protected Form", THE JOURNAL OF ORGANIC CHEMISTRY, AMERICAN CHEMICAL SOCIETY, vol. 65, no. 5, 1 March 2000 (2000-03-01), pages 1414 - 1421, XP055258119, ISSN: 0022-3263, DOI: 10.1021/jo991523w
CAROL M. TAYLOR, CLAUDETTE A. WEIR: "Synthesis of the Repeating Decapeptide Unit of Mefp1 in Orthogonally Protected Form", THE JOURNAL OF ORGANIC CHEMISTRY, AMERICAN CHEMICAL SOCIETY, vol. 65, no. 5, 1 March 2000 (2000-03-01), pages 1414 - 1421, XP055258119, ISSN: 0022-3263, DOI: 10.1021/jo991523w
Attorney, Agent or Firm:
WU, FENG & ZHANG (CN)
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