Title:
NEW DERIVATIVES OF 6-(4-PHENYLBUTOXY)HEXYLAMINE AND PROCESS FOR PRODUCING SALMETEROL
Document Type and Number:
WIPO Patent Application WO2000018722
Kind Code:
A3
Abstract:
The present invention relates to new derivatives of 6-(4-phenylbutoxy)hexylamine having the general formula (I) wherein R1 is CHO, or CHOR3OR4, wherein R3 and R4 are independently C1-C6 alkyl, aralkyl or can form cyclic acetals with 5 or 6 members; R2 is H, benzyl or a group alkyloxycarbonyl, aryloxycarbonyl, aralkyloxycarbonyl or acyle; the invention also relates to the process for producing them. The invention also relates to a new process for producing salmeterol or the pharmaceutically acceptable salts thereof and which is characterized in that an organometallic compound is reacted with a compound having the general formula (I) wherein R1 is CHO and R2 is alkyloxycarbonyl, aryloxycarbonyl, aralkyloxycarbonyl or an acyl group.
Inventors:
BESSA BELLMUNT JORDI (ES)
DALMASES BARJOAN PERE (ES)
MARQUILLAS OLONDRIZ FRANCISCO (ES)
DALMASES BARJOAN PERE (ES)
MARQUILLAS OLONDRIZ FRANCISCO (ES)
Application Number:
PCT/ES1999/000294
Publication Date:
July 06, 2000
Filing Date:
September 20, 1999
Export Citation:
Assignee:
VITA INVEST SA (ES)
BESSA BELLMUNT JORDI (ES)
DALMASES BARJOAN PERE (ES)
MARQUILLAS OLONDRIZ FRANCISCO (ES)
BESSA BELLMUNT JORDI (ES)
DALMASES BARJOAN PERE (ES)
MARQUILLAS OLONDRIZ FRANCISCO (ES)
International Classes:
C07B61/00; C07C213/02; C07C213/08; C07C217/28; C07C217/40; C07C217/42; C07C221/00; C07C223/02; C07C271/16; C07C271/18; C07D319/08; C07C217/10; (IPC1-7): C07C217/44; C07C213/08; C07D319/06
Foreign References:
| ES2065269A1 | 1995-02-01 | |||
| EP0162576A1 | 1985-11-27 | |||
| FR2545482A1 | 1984-11-09 |
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