Title:
NEW DRUG COMPLEX
Document Type and Number:
WIPO Patent Application WO/2024/034684
Kind Code:
A1
Abstract:
The present invention provides a novel copolymer utilizable for drug delivery technology. The present invention pertains to a drug complex in which a target recognition molecule is bound to a copolymer X comprising structural units represented by the following formulae (a), (b) and (c). [In the formulae, R1, R2, and R3 are the same or different and each represent a hydrogen atom or a C1-3 alkyl group; R4 represents a C1-3 alkyl group; R5 represents a hydrogen atom, a C1-18 alkyl group, an optionally substituted, 3- to 8-membered cycloalkyl group, an adamantyl group, an optionally substituted C6-18 aryl group, or an optionally substituted, 5- to 10-membered heteroaryl group; X1, X2, and X3 are the same or different and each represent an oxygen atom, a sulfur atom, or N-R7; R6 represents a hydrogen atom, a leaving group, or a linker; R7 represents a hydrogen atom or a C1-3 alkyl group; m is an integer of 1-100; and n is an integer of 0-3.]
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Inventors:
SUZUKI KENICHI (JP)
YOSHIDA HIDEO (JP)
FUJIMAKI NOBUHIRO (JP)
HOSONO KAHORI (JP)
YOSHIDA HIDEO (JP)
FUJIMAKI NOBUHIRO (JP)
HOSONO KAHORI (JP)
Application Number:
PCT/JP2023/029356
Publication Date:
February 15, 2024
Filing Date:
August 10, 2023
Export Citation:
Assignee:
KOWA CO (JP)
International Classes:
A61K47/69; A61K9/51; A61K31/282; A61K39/395; A61K47/32; A61K47/68; A61P35/00; C08F220/10; C08F220/30
Domestic Patent References:
| WO2022168967A1 | 2022-08-11 |
Foreign References:
| JP2022503966A | 2022-01-12 | |||
| JP2003231648A | 2003-08-19 |
Other References:
NISHIYAMA NOBUHIRO, MATSUMURA YASUHIRO, KATAOKA KAZUNORI: "Development of polymeric micelles for targeting intractable cancers", CANCER SCIENCE, JAPANESE CANCER ASSOCIATION, TOKYO, JP, vol. 107, no. 7, 1 July 2016 (2016-07-01), JP , pages 867 - 874, XP093139070, ISSN: 1347-9032, DOI: 10.1111/cas.12960
VICTORIA CUNNINGHAM, ET AL.: "Poly(glycerol monomethacrylate)–Poly(benzyl methacrylate) Diblock Copolymer Nanoparticles via RAFT Emulsion Polymerization: Synthesis, Characterization, and Interfacial Activity", MACROMOLECULES, AMERICAN CHEMICAL SOCIETY, US, vol. 47, no. 16, 26 August 2014 (2014-08-26), US , pages 5613 - 5623, XP055511503, ISSN: 0024-9297, DOI: 10.1021/ma501140h
JACKSON ALEXANDER W., CHANDRASEKHARAN PRASHANT, RAMASAMY BOOMINATHAN, GOGGI JULIAN, CHUANG KAI-HSIANG, HE TAO, ROBINS EDWARD G.: "Octreotide Functionalized Nano-Contrast Agent for Targeted Magnetic Resonance Imaging", BIOMACROMOLECULES, AMERICAN CHEMICAL SOCIETY, US, vol. 17, no. 12, 12 December 2016 (2016-12-12), US , pages 3902 - 3910, XP093139073, ISSN: 1525-7797, DOI: 10.1021/acs.biomac.6b01256
MARSDEN CATHERINE J., BREEN COLUM, TINKLER JAMES D., BERKI THOMAS R., LESTER DANIEL W., MARTINELLI JONATHAN, TEI LORENZO, BUTLER S: "Crosslinked p(MMA) particles by RAFT emulsion polymerisation: tuning size and stability", POLYMER CHEMISTRY, ROYAL SOCIETY OF CHEMISTRY, CAMBRIDGE, vol. 13, no. 28, 19 July 2022 (2022-07-19), Cambridge , pages 4124 - 4135, XP093139074, ISSN: 1759-9954, DOI: 10.1039/D2PY00337F
VICTORIA CUNNINGHAM, ET AL.: "Poly(glycerol monomethacrylate)–Poly(benzyl methacrylate) Diblock Copolymer Nanoparticles via RAFT Emulsion Polymerization: Synthesis, Characterization, and Interfacial Activity", MACROMOLECULES, AMERICAN CHEMICAL SOCIETY, US, vol. 47, no. 16, 26 August 2014 (2014-08-26), US , pages 5613 - 5623, XP055511503, ISSN: 0024-9297, DOI: 10.1021/ma501140h
JACKSON ALEXANDER W., CHANDRASEKHARAN PRASHANT, RAMASAMY BOOMINATHAN, GOGGI JULIAN, CHUANG KAI-HSIANG, HE TAO, ROBINS EDWARD G.: "Octreotide Functionalized Nano-Contrast Agent for Targeted Magnetic Resonance Imaging", BIOMACROMOLECULES, AMERICAN CHEMICAL SOCIETY, US, vol. 17, no. 12, 12 December 2016 (2016-12-12), US , pages 3902 - 3910, XP093139073, ISSN: 1525-7797, DOI: 10.1021/acs.biomac.6b01256
MARSDEN CATHERINE J., BREEN COLUM, TINKLER JAMES D., BERKI THOMAS R., LESTER DANIEL W., MARTINELLI JONATHAN, TEI LORENZO, BUTLER S: "Crosslinked p(MMA) particles by RAFT emulsion polymerisation: tuning size and stability", POLYMER CHEMISTRY, ROYAL SOCIETY OF CHEMISTRY, CAMBRIDGE, vol. 13, no. 28, 19 July 2022 (2022-07-19), Cambridge , pages 4124 - 4135, XP093139074, ISSN: 1759-9954, DOI: 10.1039/D2PY00337F
Attorney, Agent or Firm:
ARUGA PATENT OFFICE (JP)
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