NEW HYDROXYLAMINE DERIVATIVE - FUJISAWA PHARMACEUTICAL CO

Title:

NEW HYDROXYLAMINE DERIVATIVE

Document Type and Number:

WIPO Patent Application WO/1990/007494

Kind Code:

A1

Abstract:

This invention relates to a new hydroxylamine derivative exhibiting a 5-lipoxygenase inhibitory activity and represented by general formula (I) (wherein R1 stands for aryl, aryloxy, arylthio, aryl(lower)alkyl, or aryl(lower)alkoxy, R2 for acyl, A for hydroxyl or protected hydroxyl, X for CH2, O or S and n is an integer of 0 to 2, provided that X stands for CH2 when n is 0), pharmaceutically acceptable salts thereof, a method for preparing the same, and a medicinal composition containing the same.

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Inventors:

OKU TERUO (JP)
KAWAI YOSHIO (JP)
YATABE TAKUMI (JP)
HASHIMOTO MASASHI (JP)

Application Number:

PCT/JP1990/000003

Publication Date:

July 12, 1990

Filing Date:

January 04, 1990

Export Citation:

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Assignee:

FUJISAWA PHARMACEUTICAL CO (JP)

International Classes:

C07C259/06; C07C259/08; C07C275/64; C07D307/81; C07D311/58; C07D311/64; C07D313/08; C07D333/58; C07D335/06; C07D337/08; (IPC1-7): A61K31/16; A61K31/27; A61K31/335; A61K31/38; C07C259/04; C07D311/58; C07D313/08; C07D335/06; C07D337/08

Foreign References:

JPS63264456A	1988-11-01
JPS63502179A	1988-08-25

Other References:

Journal of Medicinal Chemistry, Vol.31, No.1, (January 1988), J. B. SUMMERS et al., (Orally Active Hydroxamic Acid Inhibitors of Leukotriene Biosynthesis), p.3-p.5

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