Title:
NEW PROLIFERATION MARKERS IN CLINICAL PRACTICE AND THEIR USE FOR CANCER PROGNOSIS OR DIAGNOSIS
Document Type and Number:
WIPO Patent Application WO2005085860
Kind Code:
A3
Abstract:
The invention relates to a method for assessing the proliferative state of cells in a human or non human biological sample, comprising using Chromatin Assembly Factor-1 (CAF-1 in short) subunits as proliferation markers. Application for cancer prognosis or diagnosis and monitoring tumor response in therapy.
More Like This:
Inventors:
ALMOUZNI GENEVIEVE (FR)
POLO SOPHIE E (FR)
THEOCHARIS STAMATIOS E (GR)
VIELH PHILIPPE (FR)
POLO SOPHIE E (FR)
THEOCHARIS STAMATIOS E (GR)
VIELH PHILIPPE (FR)
Application Number:
PCT/EP2005/002578
Publication Date:
November 10, 2005
Filing Date:
February 28, 2005
Export Citation:
Assignee:
INST CURIE (FR)
CENTRE NAT RECH SCIENT (FR)
UNIV PARIS CURIE (FR)
ALMOUZNI GENEVIEVE (FR)
POLO SOPHIE E (FR)
THEOCHARIS STAMATIOS E (GR)
VIELH PHILIPPE (FR)
CENTRE NAT RECH SCIENT (FR)
UNIV PARIS CURIE (FR)
ALMOUZNI GENEVIEVE (FR)
POLO SOPHIE E (FR)
THEOCHARIS STAMATIOS E (GR)
VIELH PHILIPPE (FR)
International Classes:
C07K14/47; G01N33/574; G01N33/68; (IPC1-7): G01N33/574; C12Q1/68
Domestic Patent References:
| WO2003025138A2 | 2003-03-27 |
Foreign References:
| US6071715A | 2000-06-06 |
Other References:
SONG H ET AL: "Genes encoding Pir51, Beclin 1, RbAp48 and aldolase b are up or down-regulated in human primary hepatocellular carcinoma", WORLD JOURNAL OF GASTROENTEROLOGY 15 FEB 2004 CHINA, vol. 10, no. 4, 15 February 2004 (2004-02-15), pages 509 - 513, XP002341462, ISSN: 1007-9327
MARHEINEKE KATHRIN ET AL: "Nucleosome assembly activity and intracellular localization of human CAF-1 changes during the cell division cycle", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 273, no. 24, 12 June 1998 (1998-06-12), pages 15279 - 15286, XP002341463, ISSN: 0021-9258
POLO SOPHIE E ET AL: "Chromatin assembly factor-1, a marker of clinical value to distinguish quiescent from proliferating cells", CANCER RESEARCH, vol. 64, no. 7, 1 April 2004 (2004-04-01), pages 2371 - 2381, XP002341464, ISSN: 0008-5472
MARHEINEKE KATHRIN ET AL: "Nucleosome assembly activity and intracellular localization of human CAF-1 changes during the cell division cycle", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 273, no. 24, 12 June 1998 (1998-06-12), pages 15279 - 15286, XP002341463, ISSN: 0021-9258
POLO SOPHIE E ET AL: "Chromatin assembly factor-1, a marker of clinical value to distinguish quiescent from proliferating cells", CANCER RESEARCH, vol. 64, no. 7, 1 April 2004 (2004-04-01), pages 2371 - 2381, XP002341464, ISSN: 0008-5472
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