NEW THIOPROLINE DERIVATIVE - YAKULT HONSHA KK

Title:

NEW THIOPROLINE DERIVATIVE

Document Type and Number:

WIPO Patent Application WO/1990/006919

Kind Code:

A1

Abstract:

This invention relates to a new thioproline derivative represented by general formula (I), wherein X is one of dialkyl acetal, dialkyl thioacetal, cyclic acetal, cyclic dithioacetal, cyclic thioaminal and diacyloxymethyl groups; or one of hydroxyiminomethyl, lower alkylaminoiminomethyl, arylaminoiminomethyl and carbomoylaminoiminomethyl groups; or a 2-benzimidazolyl group. The invention also relates to an antiamnesiac drug and a proline endopeptidase inhibitor containing said derivative as the active ingredient.

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Inventors:

SAWADA SEIGO (JP)
OKAJIMA SATORU (JP)

Application Number:

PCT/JP1989/001256

Publication Date:

June 28, 1990

Filing Date:

December 14, 1989

Export Citation:

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Assignee:

YAKULT HONSHA KK (JP)

International Classes:

C12N9/99; A61K31/425; A61K31/426; A61P25/28; A61P43/00; C07D277/06; C07D417/04; C07D417/14; (IPC1-7): A61K31/425; C07D277/06; C07D417/14; C12N9/99

Foreign References:

JPS646263A	1989-01-10
JPS6442475A	1989-02-14
JPH01250370A	1989-10-05

Other References:

CHEMICAL ABSTRACTS, Abstract No.110(3): 20344h (J. Biochem. 104(4), 580-6(1988) TSURU, DAISUKE; YOSHIMOTO, TADASHI; KORIYAMA, NOBUHIRO; FURUKAWA, SUNAO: Abstract of "Thiazolidine Derivatives as Potent Inhibitors Specific for Prolyl Endopeptidase")
See also references of EP 0414903A4

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