Title:
NEW USE OF COLCHICINE
Document Type and Number:
WIPO Patent Application WO/2022/007007
Kind Code:
A1
Abstract:
Use of colchicine, an application of the colchicine as a drug for treating hyperphosphatemia caused by chronic renal insufficiency and uremia, and an application of the colchicine as a drug for inhibiting phosphorus absorption of intestinal tracts and renal tubules. Compared with existing phosphorus-reducing drugs, the colchicine is low in price, thus facilitating reduction of expenditure of patients, clinical side effects of a small dosage of the colchicine are extremely few, and patient compliance is good.
Inventors:
XU MINGZHONG (CN)
Application Number:
PCT/CN2020/103910
Publication Date:
January 13, 2022
Filing Date:
July 24, 2020
Export Citation:
Assignee:
NANJING WUWEL HEALTHCARE CO LTD (CN)
XU MINGZHONG (CN)
XU MINGZHONG (CN)
International Classes:
A61K31/165; A61P3/00; A61P7/08; A61P13/12; A61P29/00
Other References:
LÖTSCHER MARIUS, WILSON PAUL, NGUYEN SHELLY, KAISSLING BRIGITTE, BIBER JÜRG, MURER HEINI, LEVI MOSHE: "New aspects of adaptation of rat renal Na-Pi cotransporter to alterations in dietary phosphate", KIDNEY INTERNATIONAL, NATURE PUBLISHING GROUP, LONDON, GB, vol. 49, no. 4, 1 April 1996 (1996-04-01), GB , pages 1012 - 1018, XP055886772, ISSN: 0085-2538, DOI: 10.1038/ki.1996.146
LIU, HUA, CHEN LEI;JIANG HONGLI: "Sulforaphane Reduces the Expression of the NaPi-Ⅱb Through Pregnane X Receptor", CHINESE JOURNAL OF INTEGRATED TRADITIONAL AND WESTERN NEPHROLOGY, vol. 17, no. 7, 1 July 2016 (2016-07-01), pages 578 - 581, XP055886790
MARIUS LÖTSCHER, BRIGITTE KAISSLING, JÜRG BIBER, HEINI MURER, AND MOSHE LEVI: "Role of Microtubules in the Rapid Regulation of Renal Phosphate Transport in Response to Acute Alterations in Dietary Phosphate Content", THE JOURNAL OF CLINICAL INVESTIGATION, vol. 99, no. 6, 1 March 1997 (1997-03-01), pages 1302 - 1312, XP055886780
JING YANG, LIN CHEN: "Intesinal Phosphate Absorption and its Regulated Mechanisms", CHINESE JOURNAL OF OSTEOPOROSIS AND BONE MINERAL RESEARCH, vol. 7, no. 1, 20 March 2014 (2014-03-20), pages 77 - 81, XP055886795
TATSUMI SAWAKO; MIYAGAWA ATSUMI; KANEKO ICHIRO; SHIOZAKI YUJI; SEGAWA HIROKO; MIYAMOTO KEN-ICHI: "Regulation of renal phosphate handling: inter-organ communication in health and disease", JOURNAL OF BONE AND MINERAL METABOLISM, SPRINGER, TOKYO, JP, vol. 34, no. 1, 22 August 2015 (2015-08-22), JP , pages 1 - 10, XP035889397, ISSN: 0914-8779, DOI: 10.1007/s00774-015-0705-z
KATAI KANAKO, SEGAWA HIROKO, HAGA HIROMI, MORITA KYOKO, ARAI HIDEKAZU, TATSUMI SAWAKO, TAKETANI YUTAKA, MIYAMOTO KEN-ICHI, HISANO : "Acute Regulation by Dietary Phosphate of the Sodium-Dependent Phosphate Transporter (NaPi-2) in Rat Kidney", J. BIOCHEM, 1 January 1997 (1997-01-01), pages 50 - 55, XP055886798, Retrieved from the Internet [retrieved on 20220202]
LIU, HUA, CHEN LEI;JIANG HONGLI: "Sulforaphane Reduces the Expression of the NaPi-Ⅱb Through Pregnane X Receptor", CHINESE JOURNAL OF INTEGRATED TRADITIONAL AND WESTERN NEPHROLOGY, vol. 17, no. 7, 1 July 2016 (2016-07-01), pages 578 - 581, XP055886790
MARIUS LÖTSCHER, BRIGITTE KAISSLING, JÜRG BIBER, HEINI MURER, AND MOSHE LEVI: "Role of Microtubules in the Rapid Regulation of Renal Phosphate Transport in Response to Acute Alterations in Dietary Phosphate Content", THE JOURNAL OF CLINICAL INVESTIGATION, vol. 99, no. 6, 1 March 1997 (1997-03-01), pages 1302 - 1312, XP055886780
JING YANG, LIN CHEN: "Intesinal Phosphate Absorption and its Regulated Mechanisms", CHINESE JOURNAL OF OSTEOPOROSIS AND BONE MINERAL RESEARCH, vol. 7, no. 1, 20 March 2014 (2014-03-20), pages 77 - 81, XP055886795
TATSUMI SAWAKO; MIYAGAWA ATSUMI; KANEKO ICHIRO; SHIOZAKI YUJI; SEGAWA HIROKO; MIYAMOTO KEN-ICHI: "Regulation of renal phosphate handling: inter-organ communication in health and disease", JOURNAL OF BONE AND MINERAL METABOLISM, SPRINGER, TOKYO, JP, vol. 34, no. 1, 22 August 2015 (2015-08-22), JP , pages 1 - 10, XP035889397, ISSN: 0914-8779, DOI: 10.1007/s00774-015-0705-z
KATAI KANAKO, SEGAWA HIROKO, HAGA HIROMI, MORITA KYOKO, ARAI HIDEKAZU, TATSUMI SAWAKO, TAKETANI YUTAKA, MIYAMOTO KEN-ICHI, HISANO : "Acute Regulation by Dietary Phosphate of the Sodium-Dependent Phosphate Transporter (NaPi-2) in Rat Kidney", J. BIOCHEM, 1 January 1997 (1997-01-01), pages 50 - 55, XP055886798, Retrieved from the Internet
Attorney, Agent or Firm:
JW IP LAW FIRM (CN)
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