Title:
NEW USE OF COMPOUND
Document Type and Number:
WIPO Patent Application WO/2022/007875
Kind Code:
A1
Abstract:
The present invention relates to the use of a compound of formula (I) or a pharmacologically acceptable salt, a stereoisomer, an active metabolite, a prodrug, a crystal or a solvate thereof or a composition thereof in the preparation of a drug for treating diseases related to a ryanodine receptor mutation. The present invention further relates to a method for treating diseases related to a ryanodine receptor mutation, and the compound of formula (I) or the pharmacologically acceptable salt thereof used for treating the diseases related to a ryanodine receptor mutation.
Inventors:
YUCHI ZHIGUANG (CN)
MA RUIFANG (CN)
MA DAN (CN)
JIANG HENG (CN)
ZHANG JUN (CN)
LI ZHENGMING (CN)
LI YUXIN (CN)
ZHOU SHA (CN)
MAO MINGZHEN (CN)
VAN PETEGEM FILIP (CA)
HAJI-GHASSEMI OMID (CA)
MURAYAMA TAKASHI (JP)
MA RUIFANG (CN)
MA DAN (CN)
JIANG HENG (CN)
ZHANG JUN (CN)
LI ZHENGMING (CN)
LI YUXIN (CN)
ZHOU SHA (CN)
MAO MINGZHEN (CN)
VAN PETEGEM FILIP (CA)
HAJI-GHASSEMI OMID (CA)
MURAYAMA TAKASHI (JP)
Application Number:
PCT/CN2021/105137
Publication Date:
January 13, 2022
Filing Date:
July 08, 2021
Export Citation:
Assignee:
UNIV TIANJIN (CN)
UNIV NANKAI (CN)
UNIV BRITISH COLUMBIA (CA)
JUNTENDO UNIV (JP)
UNIV NANKAI (CN)
UNIV BRITISH COLUMBIA (CA)
JUNTENDO UNIV (JP)
International Classes:
A61K31/554; C07D401/04; A61P21/00; C07D401/14; C07D405/14; C07D409/14
Foreign References:
| CN1829707A | 2006-09-06 | |||
| CN104488943A | 2015-04-08 | |||
| CN104271562A | 2015-01-07 |
Other References:
MA RUIFANG; HAJI-GHASSEMI OMID; MA DAN; JIANG HENG; LIN LIANYUN; YAO LI; SAMURKAS ARTHUR; LI YUXIN; WANG YIWEN; CAO PENG; WU SHIAN: "Structural basis for diamide modulation of ryanodine receptor", NATURE CHEMICAL BIOLOGY, NATURE PUBLISHING GROUP US, NEW YORK, vol. 16, no. 11, 17 August 2020 (2020-08-17), New York, pages 1246 - 1254, XP037272559, ISSN: 1552-4450, DOI: 10.1038/s41589-020-0627-5
MAO MING-ZHEN, LI YU-XIN, ZHOU YUN-YUN, ZHANG XIU-LAN, LIU QIAO-XIA, DI FENG-JUAN, SONG HAI-BIN, XIONG LI-XIA, LI YONG-QIANG, LI Z: "Synthesis and Insecticidal Evaluation of Novel N -Pyridylpyrazolecarboxamides Containing an Amino Acid Methyl Ester and Their Analogues", JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 62, no. 7, 19 February 2014 (2014-02-19), US , pages 1536 - 1542, XP055886595, ISSN: 0021-8561, DOI: 10.1021/jf500003d
YAN TAO, LIU PENG-FEI,ZHANG JI-FENG,YU SHU-JING,XIONG LI-XIA,LI ZHENG-MING: "Design, Synthesis and Biological Activities of Novel Ortho-Dicarboxyamides", CHEMICAL JOURNAL OF CHINESE UNIVERSITIES, JILIN DAXUE, BEIJING, CN, vol. 33, no. 8, 31 August 2012 (2012-08-31), CN , pages 1745 - 1750, XP055886600, ISSN: 0251-0790, DOI: 10.3969/j.issn.0251-0790.2012.08.021
ZHENG XUESONG, SHI LI-BO,RU LI-JUN,SU JIAN-YA: "Ryanodine Receptor and Insecticides Targeting at Ryanodine Receptor", XIANDAI NONGYAO = MODERN AGROCHEMICALS, XIAN DAI NONG YAO BIAN JI BU, CN, vol. 11, no. 3, 30 June 2012 (2012-06-30), CN , pages 1 - 6, XP055886602, ISSN: 1671-5284, DOI: 10.3969/j.issn.1671-5284.2012.03.001
DATABASE REGISTRY 11 February 2009 (2009-02-11), ANONYMOUS : "1H-Pyrazole-5-carboxamide, 3-bromo-N-[2,4-dichloro-6- [(methylamino)carbonyl]phenyl]-1-(3,5-dichloro-2-pyridinyl)- (CA INDEX NAME) OTHER CA INDEX NAMES: CN - 3-Bromo-N-[2,4-dichloro-6-[(methylamino)carbonyl]phenyl]-1-(3,5-dichloro-2- pyridinyl)-1H-pyrazole-5-carboxamide", XP055886609, retrieved from STN Database accession no. 1104384-14-6
MAO MING-ZHEN, LI YU-XIN, ZHOU YUN-YUN, ZHANG XIU-LAN, LIU QIAO-XIA, DI FENG-JUAN, SONG HAI-BIN, XIONG LI-XIA, LI YONG-QIANG, LI Z: "Synthesis and Insecticidal Evaluation of Novel N -Pyridylpyrazolecarboxamides Containing an Amino Acid Methyl Ester and Their Analogues", JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 62, no. 7, 19 February 2014 (2014-02-19), US , pages 1536 - 1542, XP055886595, ISSN: 0021-8561, DOI: 10.1021/jf500003d
YAN TAO, LIU PENG-FEI,ZHANG JI-FENG,YU SHU-JING,XIONG LI-XIA,LI ZHENG-MING: "Design, Synthesis and Biological Activities of Novel Ortho-Dicarboxyamides", CHEMICAL JOURNAL OF CHINESE UNIVERSITIES, JILIN DAXUE, BEIJING, CN, vol. 33, no. 8, 31 August 2012 (2012-08-31), CN , pages 1745 - 1750, XP055886600, ISSN: 0251-0790, DOI: 10.3969/j.issn.0251-0790.2012.08.021
ZHENG XUESONG, SHI LI-BO,RU LI-JUN,SU JIAN-YA: "Ryanodine Receptor and Insecticides Targeting at Ryanodine Receptor", XIANDAI NONGYAO = MODERN AGROCHEMICALS, XIAN DAI NONG YAO BIAN JI BU, CN, vol. 11, no. 3, 30 June 2012 (2012-06-30), CN , pages 1 - 6, XP055886602, ISSN: 1671-5284, DOI: 10.3969/j.issn.1671-5284.2012.03.001
DATABASE REGISTRY 11 February 2009 (2009-02-11), ANONYMOUS : "1H-Pyrazole-5-carboxamide, 3-bromo-N-[2,4-dichloro-6- [(methylamino)carbonyl]phenyl]-1-(3,5-dichloro-2-pyridinyl)- (CA INDEX NAME) OTHER CA INDEX NAMES: CN - 3-Bromo-N-[2,4-dichloro-6-[(methylamino)carbonyl]phenyl]-1-(3,5-dichloro-2- pyridinyl)-1H-pyrazole-5-carboxamide", XP055886609, retrieved from STN Database accession no. 1104384-14-6
Attorney, Agent or Firm:
INSIGHT INTELLECTUAL PROPERTY LIMITED (CN)
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