Title:
NFAT SIGNAL INHIBITOR AND CALCINEURIN INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2010/146622
Kind Code:
A1
Abstract:
Provided are drugs, external preparations and cosmetics having an effect of inhibiting NFAT signal, an effect of inhibiting calcineurin and an effect of promoting hair growth. An NFAT signal inhibitor which comprises as the active ingredient American angelica or an extract of the same.
Inventors:
NAGASAWA AZUMI (JP)
MORIWAKI SHIGERU (ES)
SASAKI MITSUYOSHI (JP)
MATSUOKA MEGUMI (JP)
MORIWAKI SHIGERU (ES)
SASAKI MITSUYOSHI (JP)
MATSUOKA MEGUMI (JP)
Application Number:
PCT/JP2009/002706
Publication Date:
December 23, 2010
Filing Date:
June 15, 2009
Export Citation:
Assignee:
KAO CORP (JP)
NAGASAWA AZUMI (JP)
MORIWAKI SHIGERU (ES)
SASAKI MITSUYOSHI (JP)
MATSUOKA MEGUMI (JP)
NAGASAWA AZUMI (JP)
MORIWAKI SHIGERU (ES)
SASAKI MITSUYOSHI (JP)
MATSUOKA MEGUMI (JP)
International Classes:
A61K36/23; A61K8/97; A61P1/04; A61P1/16; A61P1/18; A61P3/10; A61P9/00; A61P9/10; A61P11/00; A61P11/06; A61P13/12; A61P15/00; A61P17/00; A61P17/06; A61P17/14; A61P19/00; A61P21/00; A61P25/00; A61P29/00; A61P31/00; A61P31/04; A61P31/06; A61P31/12; A61P35/00; A61P35/02; A61P37/02; A61P37/06; A61P37/08; A61P43/00; A61Q7/00; A61Q19/00
Domestic Patent References:
| WO2009054361A1 | 2009-04-30 | |||
| WO2001035914A1 | 2001-05-25 | |||
| WO2004041221A1 | 2004-05-21 |
Foreign References:
| JPH09194334A | 1997-07-29 | |||
| JP2005089392A | 2005-04-07 | |||
| JPS6438013A | 1989-02-08 | |||
| JPS63145216A | 1988-06-17 | |||
| JP2003514000A | 2003-04-15 | |||
| JP2006508103A | 2006-03-09 | |||
| JP3527584B2 | 2004-05-17 | |||
| JP2005089392A | 2005-04-07 | |||
| JPS6438013A | 1989-02-08 | |||
| JPS63145216A | 1988-06-17 |
Other References:
BERENBAUM, M.: "Patterns of furanocoumarin distribution and insect herbivory in the Umbelliferae: plant chemistry and community structure", ECOLOGY, vol. 62, no. 5, 1981, pages 1254 - 1266
MARQUEZ, NIEVES ET AL.: "Imperatorin inhibits T-cell proliferation by targeting the transcription factor NFAT", PLANTA MEDICA, vol. 70, no. 11, November 2004 (2004-11-01), pages 1016 - 1021, XP008146854
ANAT GAFTER-GVILI ET AL.: "Cyclosporin A-induced hair growth in mice is associated with inhibition of calcineurin-dependent activation of NFAT in follicular keratinocytes", AMERICAN JOURNAL OF PHYSIOLOGY - CELL PHYSIOLOGY, vol. 284, June 2003 (2003-06-01), pages C1593 - C1603, XP008153015
GAO, YING-PING ET AL.: "Potassium hydroxide improves seed germination and emergence in five native plant species.", HORTSCIENCE, vol. 33, no. 2, April 1998 (1998-04-01), pages 274 - 276, XP008152148
ORPURT P A: "ANGELICA-ATROPURPUREA IN INDIANA USA.", PROCEEDINGS OF THE INDIANA ACADEMY OF SCIENCE, vol. 89, 1980, pages 91 - 96, XP008154045
See also references of EP 2444097A4
GAFTER-GVILI A.; SREDNI B.; GAL R.; GAFTER U.; KALECHMAN Y.: "Cyclosporin A-induced hair growth in mice is associated with inhibition of calcineurin-dependent activation of NFAT in follicular keratinocytes", AM. J. PHYSIOL. CELL PHYSIOL., vol. 284, 2003, pages C1593 - C603
LEE M.; PARK J.: "Regulation of NFAT activation: a potential therapeutic target for immunosuppression", MOL. CELLS, vol. 22, 2006, pages 1 - 7
FELDMAN S.: "Advances in psoriasis treatment", DERMATOL ONLINE J., vol. 6, no. 4, 2000
HULTSCH T.: "Immunomodulation and safety of topical calcineurin inhibitors for the treatment of atopic dermatitis", DERMATOLOGY, vol. 211, no. 2, 2005
MOLKENTIN J. D.; LU J. R.; ANTOS C. L.; MARKHAM B.; RICHARDSON J.; ROBBINS J.; GRANT S. R.; OLSON E. N.: "A calcineurin-dependent transcriptional pathway for cardiac hypertrophy", CELL, vol. 93, 1998, pages 215 - 228, XP002922813, DOI: doi:10.1016/S0092-8674(00)81573-1
URUSHIBARA M.; TAKAYANAGI H.; KOGA T.; KIM S.; ISOBE M.; MORISHITA Y.; NAKAGAWA T.; LOEFFLER M.; KODAMA T.; KUROSAWA H.: "Antirheumatic drug, leflunomide, inhibits osteoclastgenesis by interfering with RANKL-stimulated induction of NFATc1", ARTHRITIS AND RHEUMATISM, vol. 50, 2004, pages 794 - 804
TAKAYANAGI H.; KIM S.; KOGA T.; NISHINA H.; ISSHIKI M.; YOSHIDA H.; SAIURA A.; ISOBE M.; YOKOCHI T.; INOUE J.: "Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signal in terminal differentiation of osteoclasts", DEVELOPMENTAL CELL, vol. 3, 2002, pages 889 - 901, XP002994026, DOI: doi:10.1016/S1534-5807(02)00369-6
MARQUEZ, NIEVES ET AL.: "Imperatorin inhibits T-cell proliferation by targeting the transcription factor NFAT", PLANTA MEDICA, vol. 70, no. 11, November 2004 (2004-11-01), pages 1016 - 1021, XP008146854
ANAT GAFTER-GVILI ET AL.: "Cyclosporin A-induced hair growth in mice is associated with inhibition of calcineurin-dependent activation of NFAT in follicular keratinocytes", AMERICAN JOURNAL OF PHYSIOLOGY - CELL PHYSIOLOGY, vol. 284, June 2003 (2003-06-01), pages C1593 - C1603, XP008153015
GAO, YING-PING ET AL.: "Potassium hydroxide improves seed germination and emergence in five native plant species.", HORTSCIENCE, vol. 33, no. 2, April 1998 (1998-04-01), pages 274 - 276, XP008152148
ORPURT P A: "ANGELICA-ATROPURPUREA IN INDIANA USA.", PROCEEDINGS OF THE INDIANA ACADEMY OF SCIENCE, vol. 89, 1980, pages 91 - 96, XP008154045
See also references of EP 2444097A4
GAFTER-GVILI A.; SREDNI B.; GAL R.; GAFTER U.; KALECHMAN Y.: "Cyclosporin A-induced hair growth in mice is associated with inhibition of calcineurin-dependent activation of NFAT in follicular keratinocytes", AM. J. PHYSIOL. CELL PHYSIOL., vol. 284, 2003, pages C1593 - C603
LEE M.; PARK J.: "Regulation of NFAT activation: a potential therapeutic target for immunosuppression", MOL. CELLS, vol. 22, 2006, pages 1 - 7
FELDMAN S.: "Advances in psoriasis treatment", DERMATOL ONLINE J., vol. 6, no. 4, 2000
HULTSCH T.: "Immunomodulation and safety of topical calcineurin inhibitors for the treatment of atopic dermatitis", DERMATOLOGY, vol. 211, no. 2, 2005
MOLKENTIN J. D.; LU J. R.; ANTOS C. L.; MARKHAM B.; RICHARDSON J.; ROBBINS J.; GRANT S. R.; OLSON E. N.: "A calcineurin-dependent transcriptional pathway for cardiac hypertrophy", CELL, vol. 93, 1998, pages 215 - 228, XP002922813, DOI: doi:10.1016/S0092-8674(00)81573-1
URUSHIBARA M.; TAKAYANAGI H.; KOGA T.; KIM S.; ISOBE M.; MORISHITA Y.; NAKAGAWA T.; LOEFFLER M.; KODAMA T.; KUROSAWA H.: "Antirheumatic drug, leflunomide, inhibits osteoclastgenesis by interfering with RANKL-stimulated induction of NFATc1", ARTHRITIS AND RHEUMATISM, vol. 50, 2004, pages 794 - 804
TAKAYANAGI H.; KIM S.; KOGA T.; NISHINA H.; ISSHIKI M.; YOSHIDA H.; SAIURA A.; ISOBE M.; YOKOCHI T.; INOUE J.: "Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signal in terminal differentiation of osteoclasts", DEVELOPMENTAL CELL, vol. 3, 2002, pages 889 - 901, XP002994026, DOI: doi:10.1016/S1534-5807(02)00369-6
Attorney, Agent or Firm:
THE PATENT CORPORATE BODY ARUGA PATENT OFFICE (JP)
Patent business corporation Alga patent firm (JP)
Patent business corporation Alga patent firm (JP)
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