Title:
NICOTINATE AND NICOTINAMIDE RIBOSIDE-BASED COMPOUNDS AND DERIVATIVES THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/147161
Kind Code:
A3
Abstract:
Disclosed herein are compounds related to triphenylphosphonio and triphenylphosphonium derivatives of nicotinate and nicotinamide riboside and methods of making and using said compounds for treating a skin affliction or skin condition associated with or caused by inflammation, sun damage or natural aging. Also disclosed herein are methods of making nicotinic acid mononucleoside (NAMN).
Inventors:
PENTELUTE BRADLEY (US)
GUNASEKERA DINARA (US)
KONG KEVIN (US)
JOHNSON SABRINA (US)
GUNASEKERA DINARA (US)
KONG KEVIN (US)
JOHNSON SABRINA (US)
Application Number:
PCT/US2023/011957
Publication Date:
October 05, 2023
Filing Date:
January 31, 2023
Export Citation:
Assignee:
NEW FRONTIER BIO INC (US)
International Classes:
C07D213/79; A61K31/455; A61K31/708; C07D213/78; C07D213/803; C07F9/50; A61P17/06; A61P25/16; A61P25/28; A61Q19/08
Domestic Patent References:
| WO2002070445A1 | 2002-09-12 | |||
| WO2019132117A1 | 2019-07-04 | |||
| WO2015186068A1 | 2015-12-10 | |||
| WO2014111906A1 | 2014-07-24 | |||
| WO2012037038A1 | 2012-03-22 | |||
| WO2019244002A1 | 2019-12-26 |
Foreign References:
| US20150064175A1 | 2015-03-05 | |||
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| US20160355539A1 | 2016-12-08 | |||
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| US20210309685A1 | 2021-10-07 | |||
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Other References:
STOYANOVSKY DETCHO A., JIANG JIANFEI, MURPHY MICHAEL P., EPPERLY MICHAEL, ZHANG XIAOLAN, LI SONG, GREENBERGER JOEL, KAGAN VALERIAN: "Design and Synthesis of a Mitochondria-Targeted Mimic of Glutathione Peroxidase, MitoEbselen-2, as a Radiation Mitigator", ACS MEDICINAL CHEMISTRY LETTERS, AMERICAN CHEMICAL SOCIETY, US, vol. 5, no. 12, 11 December 2014 (2014-12-11), US , pages 1304 - 1307, XP093099880, ISSN: 1948-5875, DOI: 10.1021/ml5003635
DATABASE PUBCHEM COMPOUND ANONYMOUS : "Triphenyl-[(pyridine-3carbonylamino)methyl]phosphanium", XP093099810, retrieved from PUBCHEM
OCHTROP PHILIPP: "Selective protein functionalisation via enzymatic phosphocholination", DOCTORAL THESIS, UMEA UNIVERSITY, 1 January 2017 (2017-01-01), XP093099884, Retrieved from the Internet [retrieved on 20231109]
REZENDE MARCOS CAROLI, VALLEJOS GABRIEL, OSORIO-OLIVARES MAURICIO, SEPĂLVEDA-BOZA SILVIA: "SYNTHESIS OF SOME MODIFIED NUCLEOTIDES OF CYTIDINE", SYNTHETIC COMMUNICATIONS, TAYLOR & FRANCIS INC., US, vol. 31, no. 23, 1 January 2001 (2001-01-01), US , pages 3699 - 3705, XP093099886, ISSN: 0039-7911, DOI: 10.1081/SCC-100107020
ROMANENKO VADIM D., KUKHAR VALERY P.: "Phosphonate analogues of nucleoside polyphosphates", ARKIVOC, vol. 2018, no. 1, pages 1 - 49, XP093099888, DOI: 10.24820/ark.5550190.p010.183
YOSHIKAWA, M ET AL.: "Studies of Phosphorylation. III. Selective Phosphorylation of Unprotected Nucleosides", BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, vol. 42, no. 12, 1969, pages 3505 - 3508, XP000654220
DATABASE PUBCHEM COMPOUND ANONYMOUS : "Triphenyl-[(pyridine-3carbonylamino)methyl]phosphanium", XP093099810, retrieved from PUBCHEM
OCHTROP PHILIPP: "Selective protein functionalisation via enzymatic phosphocholination", DOCTORAL THESIS, UMEA UNIVERSITY, 1 January 2017 (2017-01-01), XP093099884, Retrieved from the Internet
REZENDE MARCOS CAROLI, VALLEJOS GABRIEL, OSORIO-OLIVARES MAURICIO, SEPĂLVEDA-BOZA SILVIA: "SYNTHESIS OF SOME MODIFIED NUCLEOTIDES OF CYTIDINE", SYNTHETIC COMMUNICATIONS, TAYLOR & FRANCIS INC., US, vol. 31, no. 23, 1 January 2001 (2001-01-01), US , pages 3699 - 3705, XP093099886, ISSN: 0039-7911, DOI: 10.1081/SCC-100107020
ROMANENKO VADIM D., KUKHAR VALERY P.: "Phosphonate analogues of nucleoside polyphosphates", ARKIVOC, vol. 2018, no. 1, pages 1 - 49, XP093099888, DOI: 10.24820/ark.5550190.p010.183
YOSHIKAWA, M ET AL.: "Studies of Phosphorylation. III. Selective Phosphorylation of Unprotected Nucleosides", BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, vol. 42, no. 12, 1969, pages 3505 - 3508, XP000654220
Attorney, Agent or Firm:
GORDON, Dana, M. et al. (US)
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