Title:
NIFEDIPINE-METOPROLOL SUSTAINED-RELEASE COMPOSITION, PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/247952
Kind Code:
A1
Abstract:
Disclosed are a nifedipine-metoprolol sustained-release composition, a preparation method therefor and the use thereof. The sustained-release composition overcomes the huge differences in the solubility of the two drugs of nifedipine, a pharmaceutically acceptable salt or solvate thereof, and metoprolol, a pharmaceutically acceptable salt or solvate thereof, the two antihypertensive drugs with complementary action mechanisms are prepared into a daily long-acting compound preparation by means of a single-chamber double-layer osmotic pump drug release mechanism, so that the two drugs achieve long-acting synchronous release, and the 24-hour cumulative release degree of the two drugs can reach at least 85%. The sustained-release composition has a stable preparation process, convenience in terms of production and a conduciveness to industrial production.
Inventors:
GUO ZHEN (CN)
CHEN LINA (CN)
CHEN ZUYOU (CN)
CHENG MINGXUAN (CN)
XIE WENFENG (CN)
WANG TINGTING (CN)
YING SHUHUAN (CN)
CHEN LINA (CN)
CHEN ZUYOU (CN)
CHENG MINGXUAN (CN)
XIE WENFENG (CN)
WANG TINGTING (CN)
YING SHUHUAN (CN)
Application Number:
PCT/CN2022/095871
Publication Date:
December 01, 2022
Filing Date:
May 30, 2022
Export Citation:
Assignee:
SHANGHAI BOCIMED PHARMACEUTICAL CO LTD (CN)
International Classes:
A61K31/4422; A61K9/22; A61K9/30; A61K9/36; A61K9/44; A61K31/138; A61P9/12
Foreign References:
| US4327725A | 1982-05-04 | |||
| US4765989A | 1988-08-23 | |||
| US5082668A | 1992-01-21 | |||
| US5422123A | 1995-06-06 |
Other References:
KUMARAVELRAJAN, R. ; NARAYANAN, N. ; SUBA, V. ; BHASKAR, K.: "Simultaneous delivery of Nifedipine and Metoprolol tartarate using sandwiched osmotic pump tablet system", INTERNATIONAL JOURNAL OF PHARMACEUTICS, ELSEVIER, NL, vol. 399, no. 1-2, 31 October 2010 (2010-10-31), NL , pages 60 - 70, XP027298455, ISSN: 0378-5173
ZHAO SHIQING, ET AL.: "Synchronous delivery of felodipine and metoprolol tartrate using monolithic osmotic pump technology", DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, vol. 42, no. 11, 13 April 2016 (2016-04-13), pages 1723 - 1731, XP093007077, DOI: 10.3109/03639045.2016.1171332
RAJAGOPAL KUMARAVELRAJAN;NALLAPERUMAL NARAYANAN;VENKATESAN SUBA: "Development and evaluation of controlled porosity osmotic pump for Nifedipine and Metoprolol combination", LIPIDS IN HEALTH AND DISEASE, BIOMED CENTRAL, LONDON, GB, vol. 10, no. 1, 11 April 2011 (2011-04-11), GB , pages 51, XP021097880, ISSN: 1476-511X, DOI: 10.1186/1476-511X-10-51
KUMARAVELRAJAN RAJAGOPAL, NARAYANAN NALLAPERUMAL, SUBA VENKATESAN: "Development and Evaluation of Elementary Osmotic Pump for the Simultaneous Delivery of Nifedipine and Metoprolol Tartrate INTRODUCTION", ASIAN JOURNAL OF PHARMACEUTICS, vol. 10, no. 4, 31 December 2016 (2016-12-31), XP093007071
ZHAO SHIQING, ET AL.: "Synchronous delivery of felodipine and metoprolol tartrate using monolithic osmotic pump technology", DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, vol. 42, no. 11, 13 April 2016 (2016-04-13), pages 1723 - 1731, XP093007077, DOI: 10.3109/03639045.2016.1171332
RAJAGOPAL KUMARAVELRAJAN;NALLAPERUMAL NARAYANAN;VENKATESAN SUBA: "Development and evaluation of controlled porosity osmotic pump for Nifedipine and Metoprolol combination", LIPIDS IN HEALTH AND DISEASE, BIOMED CENTRAL, LONDON, GB, vol. 10, no. 1, 11 April 2011 (2011-04-11), GB , pages 51, XP021097880, ISSN: 1476-511X, DOI: 10.1186/1476-511X-10-51
KUMARAVELRAJAN RAJAGOPAL, NARAYANAN NALLAPERUMAL, SUBA VENKATESAN: "Development and Evaluation of Elementary Osmotic Pump for the Simultaneous Delivery of Nifedipine and Metoprolol Tartrate INTRODUCTION", ASIAN JOURNAL OF PHARMACEUTICS, vol. 10, no. 4, 31 December 2016 (2016-12-31), XP093007071
Attorney, Agent or Firm:
BEIJING ORIGINTELLIGENCE IP LAW FIRM (CN)
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