Title:
NITRIC OXIDE DONATING DERIVATIVES FOR THE TREATMENT OF CARDIOVASCULAR DISORDERS
Document Type and Number:
WIPO Patent Application WO2005032559
Kind Code:
A8
Abstract:
Compounds for inducing the expression of ApoA1, comprising a donatable nitric oxide moiety and a free-radical scavenging moiety. Preferably, nitric oxide derivatives of stilbenes, polyphenols, flavonoids and isoflavonoids and methods of their use are provided for treating patients suffering from diseases including hypercholesterolemia, vascular oxidative stress and endothelial dysfunction.
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Inventors:
WONG NORMAN (CA)
TUCKER JOE (CA)
MCCAFFREY DAVID ROBERT (CA)
TUCKER JOE (CA)
MCCAFFREY DAVID ROBERT (CA)
Application Number:
PCT/CA2004/001805
Publication Date:
June 16, 2005
Filing Date:
October 07, 2004
Export Citation:
Assignee:
RESVERLOGIX CORP (CA)
WONG NORMAN (CA)
TUCKER JOE (CA)
MCCAFFREY DAVID ROBERT (CA)
WONG NORMAN (CA)
TUCKER JOE (CA)
MCCAFFREY DAVID ROBERT (CA)
International Classes:
A61K31/353; A61K31/7048; A61P3/06; A61P9/00; C07D311/32; (IPC1-7): A61K31/66; C07D311/36; C07D311/38; C07D215/233; C07D215/04; C07C15/18; A61K31/352; A61P9/00; A61K31/353; A61K31/04; A61K31/05; A61K31/015; A61K31/397; A61K31/122; A61K31/404; A61K31/40; A61K31/44; A61K31/505; A61P3/06
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