Title:
NITROGEN-CONTAINING CATIONIC LIPID AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/061460
Kind Code:
A1
Abstract:
Provided is a novel cationic lipid having a structure as represented in general formula (1), which specifically relates to a nitrogen-containing cationic lipid, and also relates to a liposome containing the cationic lipid, a liposome pharmaceutical composition containing the cationic lipid, and a preparation and an application thereof. The definition of each symbol in the formula is as defined herein. The present invention relates to a cationic liposome containing the cationic lipid represented by formula (1), which may improve the loading rate and transport rate of drugs, particularly nucleic acid drugs. A terminus of the novel cationic lipid may also contain a fluorescent group or a targeting group, so that the cationic liposome pharmaceutical composition containing the cationic lipid may have both fluorescent and targeting functions. A cationic liposome nucleic acid pharmaceutical composition preparation to which the present invention relates has a very good gene complexing ability and high gene transfection ability, thereby further improving a gene treatment and/or diagnostic effect of a drug, and providing the field of drug delivery with more selectable cationic lipids.
More Like This:
Inventors:
LIN SHENG (CN)
LIN MINGGUI (CN)
WANG AILAN (CN)
WANG LINLIN (CN)
WENG WENGUI (CN)
LIU CHAO (CN)
YUAN JINCHUN (CN)
LIN QIAN (CN)
LIN MINGGUI (CN)
WANG AILAN (CN)
WANG LINLIN (CN)
WENG WENGUI (CN)
LIU CHAO (CN)
YUAN JINCHUN (CN)
LIN QIAN (CN)
Application Number:
PCT/CN2022/125227
Publication Date:
April 20, 2023
Filing Date:
October 13, 2022
Export Citation:
Assignee:
XIAMEN SINOPEG BIOTECH CO LTD (CN)
International Classes:
C07C219/06; A61K9/127; A61K31/7105; A61K31/713; A61K47/18; A61P43/00; C07C217/08; C07C229/10; C07C229/26; C07C235/10
Domestic Patent References:
| WO2021030701A1 | 2021-02-18 |
Foreign References:
| CN113402405A | 2021-09-17 | |||
| CN110352071A | 2019-10-18 | |||
| CN104876831A | 2015-09-02 | |||
| CN115197078A | 2022-10-18 | |||
| CN115197079A | 2022-10-18 | |||
| CN115197080A | 2022-10-18 |
Download PDF: