NITROGEN-CONTAINING HETEROAROMATIC RING COMPOUND AS WELL AS COMPOSITION AND PHARMACEUTICAL USE THEREOF

Title:

NITROGEN-CONTAINING HETEROAROMATIC RING COMPOUND AS WELL AS COMPOSITION AND PHARMACEUTICAL USE THEREOF

Document Type and Number:

WIPO Patent Application WO/2023/143370

Kind Code:

A1

Abstract:

The present invention relates to a compound represented by general formula (I), or stereoisomers, deuterated substances, solvates, prodrugs, metabolites, pharmaceutically acceptable salts or eutectic crystals thereof, an intermediate thereof, and the use thereof in BRD9-related diseases such as cancer. B-L-K (I)

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Inventors:

ZHANG CHEN (CN)
HE PING (CN)
WEI QI (CN)
NING WENTAO (CN)
YU YAN (CN)
TANG PINGMING (CN)
LI YAO (CN)
YAN PANGKE (CN)

Application Number:

PCT/CN2023/073145

Publication Date:

August 03, 2023

Filing Date:

January 19, 2023

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Assignee:

SICHUAN HAISCO PHARMACEUTICAL CO LTD (CN)

International Classes:

C07D471/04; A61K31/45; A61P35/00; A61P37/00; C07D401/04; C07D401/14; C07D495/04

Domestic Patent References:

WO2021178920A1

2021-09-10

Foreign References:

CN109641874A	2019-04-16
US20190247509A1	2019-08-15

Other References:

DATABASE Registry 3 October 2021 (2021-10-03), ANONYMOUS: "2,6-Piperidinedione, 3-[[4-[4-[1-[[2-chloro-4-(1,2-dihydro-2-methyl-1-oxo- 2,7-naphthyridin-4-yl)-6-methoxyphenyl]methyl]-3,3-difluoro-4-piperidinyl]- 1-piperazinyl]-3-fluorophenyl]methylamino]- (CA INDEX NAME)", XP093082059, retrieved from STNext Database accession no. 2704618-87-9
DATABASE Registry 3 October 2021 (2021-10-03), ANONYMOUS: "2,6-Piperidinedione, 3-[[4-[4-[1-[[2-chloro-4-(1,6-dihydro-1,4,5-trimethyl- 6-oxo-3-pyridinyl)-6-methoxyphenyl]methyl]-3,3-difluoro-4-piperidinyl]-1- piperazinyl]-3-fluorophenyl]methylamino]- (CA INDEX NAME)", XP093082060, retrieved from STNext Database accession no. 2704618-83-5

Attorney, Agent or Firm:

BEIJING SANYOU INTELLECTUAL PROPERTY AGENCY LTD. (CN)

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