Title:
NITROGEN-CONTAINING HETEROCYCLIC COMPOUND HAVING NRF2 ACTIVATION EFFECT
Document Type and Number:
WIPO Patent Application WO/2023/132369
Kind Code:
A1
Abstract:
Provided is a compound able to activate Nrf2 and represented by formula (1), a salt thereof, or a solvate of these. Formula (1) (In the formula, Xa1 is CRa1 or N, Xa3 is CRa3 or N, Ra1, Ra2, and Ra3 are each independently selected from the group consisting of hydrogen, halogens, and C1–C6 alkoxy groups, Xb1, Xb2, and Xb3 are each independently selected from the group consisting of CH2, O, NH, S, and C=O, Y is an optionally substituted C6–C10 aryl or an optionally substituted 5– to 10-member heteroaryl, and Z is an optionally substituted C6–C10 aryl, an optionally substituted 5– to 10-member heteroaryl, or an optionally substituted C1–C6 alkyl.)
More Like This:
Inventors:
KIMBARA ATSUSHI (JP)
HARADA TAKEO (JP)
KOMIYAMA SUSUMU (JP)
OKUYAMA MIZUKI (JP)
OHTAKE YOSHIHITO (JP)
MURATA YOSHIHISA (JP)
SAITO RIE (JP)
HARADA TAKEO (JP)
KOMIYAMA SUSUMU (JP)
OKUYAMA MIZUKI (JP)
OHTAKE YOSHIHITO (JP)
MURATA YOSHIHISA (JP)
SAITO RIE (JP)
Application Number:
PCT/JP2023/000211
Publication Date:
July 13, 2023
Filing Date:
January 06, 2023
Export Citation:
Assignee:
CHUGAI PHARMACEUTICAL CO LTD (JP)
International Classes:
C07D217/06; A61K31/472; A61K31/4725; A61K31/5377; A61K31/5386; A61K31/541; A61K31/5415; A61K31/551; A61P11/00; A61P13/12; A61P25/00; A61P43/00; C07D237/32; C07D265/14; C07D279/08; C07D401/10; C07D401/14; C07D403/10; C07D413/06; C07D413/10; C07D413/12; C07D413/14; C07D417/10; C07D471/04; C07D487/04; C07D487/10; C07D491/048; C07D491/107; C07D498/04; C07D498/08; C07D519/00
Domestic Patent References:
| WO2020084300A1 | 2020-04-30 | |||
| WO2016036633A1 | 2016-03-10 | |||
| WO2014059214A1 | 2014-04-17 |
Foreign References:
| CN114507181A | 2022-05-17 | |||
| CN110294744A | 2019-10-01 |
Attorney, Agent or Firm:
HASEGAWA Yoshiki et al. (JP)
Download PDF: