Title:
NITROGEN-CONTAINING HETEROCYCLIC COMPOUND AND PHARMACEUTICAL USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/067694
Kind Code:
A1
Abstract:
The present invention relates to a nitrogen-containing heterocyclic compound and pharmaceutical use thereof. Specifically, the present invention relates to a nitrogen-containing heterocyclic compound represented by general formula (I), a preparation method therefor, a pharmaceutical composition containing same, and use thereof as a poly(ADP-ribose) polymerase 1 (PARP1) inhibitor for treating a disease related to PARP1 activity. The definition of each group in general formula (I) is the same as that in the description.
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Inventors:
LIU GUOBIAO (CN)
WANG GUOZHENG (CN)
YAN XU (CN)
LI BIN (CN)
REN YUE (CN)
LI JIANHAO (CN)
XIN PIMING (CN)
ZHAO LIKUN (CN)
WANG GUOZHENG (CN)
YAN XU (CN)
LI BIN (CN)
REN YUE (CN)
LI JIANHAO (CN)
XIN PIMING (CN)
ZHAO LIKUN (CN)
Application Number:
PCT/CN2023/122005
Publication Date:
April 04, 2024
Filing Date:
September 27, 2023
Export Citation:
Assignee:
THE NAT INSTITUTES OF PHARMACEUTICAL R & D CO LTD (CN)
International Classes:
C07D471/04; A61K31/4353; A61K31/4375; A61K31/496; A61K31/498; A61P35/00; A61P35/02; C07D401/14; C07D403/14; C07D405/14; C07D487/04
Domestic Patent References:
| WO2022223025A1 | 2022-10-27 | |||
| WO2022225934A1 | 2022-10-27 | |||
| WO2022228387A1 | 2022-11-03 | |||
| WO2023051716A1 | 2023-04-06 | |||
| WO2023036285A1 | 2023-03-16 | |||
| WO2023046034A1 | 2023-03-30 | |||
| WO2023109521A1 | 2023-06-22 | |||
| WO2022222995A1 | 2022-10-27 | |||
| WO2023051807A1 | 2023-04-06 | |||
| WO2023051812A1 | 2023-04-06 | |||
| WO2022074617A1 | 2022-04-14 |
Foreign References:
| CN116496271A | 2023-07-28 | |||
| CN114144413A | 2022-03-04 |
Other References:
REN JUNKANG, QUAN XU, LIU YING, LI JIANI, ZHANG XIAOYU, LI ZHIYU, ZHANG XIAOMENG: "Synthesis and in vitro biological evaluation of 3-ethyl-1,5-naphthyridin-2(1H)-one derivatives as potent PARP-1 selective inhibitors and PARP-1 DNA trappers", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, ELSEVIER, AMSTERDAM NL, vol. 78, 31 October 2022 (2022-10-31), Amsterdam NL , pages 129046, XP093067861, ISSN: 0960-894X, DOI: 10.1016/j.bmcl.2022.129046
Attorney, Agent or Firm:
GE CHENG & CO., LTD. (CN)
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