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Title:
NITROGEN-CONTAINING HETEROCYCLIC COMPOUND AND USE OF SAME
Document Type and Number:
WIPO Patent Application WO/2010/032856
Kind Code:
A1
Abstract:
A compound represented by formula (I) [wherein ring A represents a nitrogen-containing heterocycle; ring B represents an optionally substituted aromatic cycle; ring D represents an optionally substituted aromatic cycle; L represents a group represented by formula (II)(wherein R2, R3, R4a and R4b independently represent each a hydrogen atom, an optionally halogenated C1-6 alkyl group or an optionally halogenated C3-6 cycloalkyl group, or R2 and R3 may be bonded to each other via an alkylene chain or an alkenylene chain, or R4a and R4b may be bonded to each other via an alkylene chain or an alkenylene chain); R1 represents a hydrogen atom or a substituent; m and n independently represent each an integer of 0 to 5; m+n is an integer of 2 to 5; and --- represents a single bond or a double bond], a salt of the same and so on.  Because of having an excellent tachykinin receptor antagonism, the aforesaid compound is useful as a preventive/remedy for various diseases such as lower urinary tract diseases, digestive diseases and central nervous diseases.

Inventors:
SHIRAI JUNYA (JP)
SUGIYAMA HIDEYUKI (JP)
KAMEI TAKU (JP)
MAEZAKI HIRONOBU (JP)
Application Number:
PCT/JP2009/066458
Publication Date:
March 25, 2010
Filing Date:
September 18, 2009
Export Citation:
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Assignee:
TAKEDA PHARMACEUTICAL (JP)
SHIRAI JUNYA (JP)
SUGIYAMA HIDEYUKI (JP)
KAMEI TAKU (JP)
MAEZAKI HIRONOBU (JP)
International Classes:
C07D207/14; A61K31/40; A61K31/4025; A61K31/41; A61K31/4178; A61K31/422; A61K31/427; A61K31/4439; A61K31/445; A61K31/4468; A61K31/4525; A61K31/4535; A61K31/4545; A61K31/496; A61K31/506; A61K31/5377; A61K31/541; A61P1/04; A61P1/08; A61P13/10; A61P25/04; A61P25/22; A61P25/24; A61P43/00; C07D211/58; C07D401/04; C07D401/06; C07D401/12; C07D401/14; C07D403/04; C07D403/06; C07D403/10; C07D405/06; C07D405/12; C07D409/04; C07D409/06; C07D409/12; C07D413/04; C07D413/06; C07D413/08; C07D413/14; C07D417/08
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Attorney, Agent or Firm:
TAKASHIMA, HAJIME (JP)
Takashima 1 (JP)
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