Title:
NITROGEN-CONTAINING HETEROCYCLIC COMPOUND AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/174381
Kind Code:
A1
Abstract:
The present invention relates to a nitrogen-containing heterocyclic compound and the use thereof. Specifically, provided is a compound of formula I, or an optical isomer thereof, or a racemate thereof, or a solvate thereof, or a pharmaceutically acceptable salt thereof, or a deuterated compound thereof. The compound has excellent and precise therapeutic effects on tumors with low expression or non-expression of the NNMT gene, high expression of DNA methylase, high expression of UHRF1, a high methylation level of nucleotide sites of the NNMT gene, and/or a high methylation level of DNA CpG site in a NNMT gene region.
Inventors:
SHI YUFENG (CN)
MA WENJIANG (CN)
PEI GANG (CN)
XIA PENG (CN)
MA WENJIANG (CN)
PEI GANG (CN)
XIA PENG (CN)
Application Number:
PCT/CN2023/081983
Publication Date:
September 21, 2023
Filing Date:
March 16, 2023
Export Citation:
Assignee:
NANJING SHIJIANG MEDICINE TECH CO LTD (CN)
International Classes:
C07D455/03; A61K31/4375; A61P35/00
Domestic Patent References:
| WO2022063311A1 | 2022-03-31 |
Foreign References:
| US20100120810A1 | 2010-05-13 | |||
| JPS5019780A | 1975-03-01 | |||
| JPS5070397A | 1975-06-11 | |||
| CN104211697A | 2014-12-17 | |||
| CN113599380A | 2021-11-05 |
Other References:
DATABASE REGISTRY ANONYMOUS : "- 6H-Bis[1,3]benzodioxolo[5,6-a:5',6'-g]quinolizine, 5,8-dihydro- (CA INDEX NAME) ", XP093092723, retrieved from STN
QIAN, PING ET AL.: "Alkaloids from Zuojin Formula And Their Cytotoxicities against Proliferation of Cancer Cells", CHINESE TRADITIONAL AND HERBAL DRUGS, vol. 45, no. 1, 31 January 2014 (2014-01-31), pages 8 - 15, XP093091792, DOI: 10.7501/j.issn.0253-2670.2014.01.002
ZHANG, YAN ET AL.: "DNA (Study on Pharmacological Action Mechanism of Berberine Chloride by Genome-wide Expression Profiling of Saccharomyces cerevisiae", CHINESE JOURNAL OF INTEGRATED TRADITIONAL AND WESTERN MEDICINE, vol. 23, no. 1, 31 December 2003 (2003-12-31), pages 48 - 53, XP055928796
DU PEIFANG, YAN JIANHUA, LONG SHUO, XIONG HONGJIE, WEN NACHUAN, CAI SHUNDONG, WANG YIRONG, PENG DONGMING, LIU ZHENBAO, LIU YANFEI: "Tumor microenvironment and NIR laser dual-responsive release of berberine 9- O -pyrazole alkyl derivative loaded in graphene oxide nanosheets for chemo-photothermal synergetic cancer therapy", JOURNAL OF MATERIALS CHEMISTRY. B, ROYAL SOCIETY OF CHEMISTRY, GB, vol. 8, no. 18, 14 May 2020 (2020-05-14), GB , pages 4046 - 4055, XP093092719, ISSN: 2050-750X, DOI: 10.1039/D0TB00489H
QIAN, PING ET AL.: "Alkaloids from Zuojin Formula And Their Cytotoxicities against Proliferation of Cancer Cells", CHINESE TRADITIONAL AND HERBAL DRUGS, vol. 45, no. 1, 31 January 2014 (2014-01-31), pages 8 - 15, XP093091792, DOI: 10.7501/j.issn.0253-2670.2014.01.002
ZHANG, YAN ET AL.: "DNA (Study on Pharmacological Action Mechanism of Berberine Chloride by Genome-wide Expression Profiling of Saccharomyces cerevisiae", CHINESE JOURNAL OF INTEGRATED TRADITIONAL AND WESTERN MEDICINE, vol. 23, no. 1, 31 December 2003 (2003-12-31), pages 48 - 53, XP055928796
DU PEIFANG, YAN JIANHUA, LONG SHUO, XIONG HONGJIE, WEN NACHUAN, CAI SHUNDONG, WANG YIRONG, PENG DONGMING, LIU ZHENBAO, LIU YANFEI: "Tumor microenvironment and NIR laser dual-responsive release of berberine 9- O -pyrazole alkyl derivative loaded in graphene oxide nanosheets for chemo-photothermal synergetic cancer therapy", JOURNAL OF MATERIALS CHEMISTRY. B, ROYAL SOCIETY OF CHEMISTRY, GB, vol. 8, no. 18, 14 May 2020 (2020-05-14), GB , pages 4046 - 4055, XP093092719, ISSN: 2050-750X, DOI: 10.1039/D0TB00489H
Attorney, Agent or Firm:
PANCHINA IP LAW OFFICE (CN)
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