NITROGEN-CONTAINING HETEROCYCLIC DERIVATIVE INHIBITOR, AND PREPARATION METHOD THEREFOR AND USE THEREOF

Title:

NITROGEN-CONTAINING HETEROCYCLIC DERIVATIVE INHIBITOR, AND PREPARATION METHOD THEREFOR AND USE THEREOF

Document Type and Number:

WIPO Patent Application WO/2023/025320

Kind Code:

A1

Abstract:

Disclosed are a nitrogen-containing heterocyclic derivative inhibitor, and a preparation method therefor and the use thereof. Disclosed are a compound represented by general formula (I), a preparation method therefor, and the use thereof as an EGFR inhibitor in treating cancer.

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WO/2008/009435	AMINO-PIPERIDINE DERIVATIVES AS CETP INHIBITORS
WO/2014/199933	BICYCLIC NITROGEN-CONTAINING AROMATIC HETEROCYCLIC AMIDE COMPOUND

Inventors:

GAO PENG (CN)
XIU WENHUA (CN)
SUN GUANGJUN (CN)
CHENG FENGCHANG (CN)
YU WENSHENG (CN)

Application Number:

PCT/CN2022/115479

Publication Date:

March 02, 2023

Filing Date:

August 29, 2022

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Assignee:

SHANGHAI HANSOH BIOMEDICAL CO LTD (CN)
JIANGSU HANSOH PHARMACEUTICAL GROUP CO LTD (CN)

International Classes:

C07D401/14; A61K31/506; A61P35/00; C07D471/04; C07D491/04

Domestic Patent References:

WO2021133809A1	2021-07-01
WO2014210354A1	2014-12-31
WO2013131424A1	2013-09-12
WO2021104305A1	2021-06-03

Foreign References:

CN112079830A

2020-12-15

Other References:

NAGASAKA MISAKO, ZHU VIOLA W., LIM SUN MIN, GRECO MICHAEL, WU FENGYING, OU SAI-HONG IGNATIUS: "Beyond Osimertinib: The Development of Third-Generation EGFR Tyrosine Kinase Inhibitors For Advanced EGFR+ NSCLC", JOURNAL OF THORACIC ONCOLOGY, ELSEVIER INC., US, vol. 16, no. 5, 1 May 2021 (2021-05-01), US , pages 740 - 763, XP093039974, ISSN: 1556-0864, DOI: 10.1016/j.jtho.2020.11.028

Attorney, Agent or Firm:

GE CHENG & CO., LTD. (CN)

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