Title:
NITROGEN-CONTAINING HETEROCYCLIC DERIVATIVE INHIBITOR, PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/174406
Kind Code:
A1
Abstract:
The present invention relates to a nitrogen-containing heterocyclic derivative EGFR inhibitor, a preparation method therefor and a use thereof. In particular, the present invention relates to a compound represented by general formula (I), a preparation method therefor, a pharmaceutical composition containing the compound, and a use thereof as an EGFR inhibitor in treating cancer.
Inventors:
GAO PENG (CN)
ZENG MI (CN)
SUN GUANGJUN (CN)
CHENG FENGCHANG (CN)
XIU WENHUA (CN)
YU WENSHENG (CN)
ZENG MI (CN)
SUN GUANGJUN (CN)
CHENG FENGCHANG (CN)
XIU WENHUA (CN)
YU WENSHENG (CN)
Application Number:
PCT/CN2023/082178
Publication Date:
September 21, 2023
Filing Date:
March 17, 2023
Export Citation:
Assignee:
SHANGHAI HANSOH BIOMEDICAL CO LTD (CN)
JIANGSU HANSOH PHARMACEUTICAL GROUP CO LTD (CN)
JIANGSU HANSOH PHARMACEUTICAL GROUP CO LTD (CN)
International Classes:
C07D401/14; A61K31/506; A61P35/00; C07D417/14; C07D471/04
Domestic Patent References:
| WO2021168074A1 | 2021-08-26 | |||
| WO2021133809A1 | 2021-07-01 | |||
| WO2021104305A1 | 2021-06-03 |
Foreign References:
| CN115650958A | 2023-01-31 | |||
| CN115724827A | 2023-03-03 | |||
| US20160257682A1 | 2016-09-08 |
Other References:
BRYAN K. CHAN, EMILY J. HANAN, KRISTA K. BOWMAN, MARIAN C. BRYAN, DANIEL BURDICK, EMILY CHAN, YUAN CHEN, SAUNDRA CLAUSEN, TRISHA D: "Discovery of a Noncovalent, Mutant-Selective Epidermal Growth Factor Receptor Inhibitor", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 59, no. 19, 13 October 2016 (2016-10-13), US , pages 9080 - 9093, XP055497250, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.6b00995
Attorney, Agent or Firm:
GE CHENG & CO., LTD. et al. (CN)
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