Title:
NITROGEN-CONTAINING HETEROCYCLIC DERIVATIVE PARP INHIBITOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/051812
Kind Code:
A1
Abstract:
Provided are a compound represented by formula (I), a stereoisomer, pharmaceutically acceptable salt, solvate, and eutectic or deuterated compound thereof, or a pharmaceutical composition comprising same, and a use thereof as a PARP-1 inhibitor in the preparation of a medication for treating related diseases. Each group in formula (I) is as defined in the description.
Inventors:
LI YAO (CN)
ZHANG HAOLIANG (CN)
CHEN LEI (CN)
FANG LINYONG (CN)
WANG LONG (CN)
LUO YUFENG (CN)
TANG PINGMING (CN)
YU YAN (CN)
ZHANG CHEN (CN)
YAN PANGKE (CN)
ZHANG HAOLIANG (CN)
CHEN LEI (CN)
FANG LINYONG (CN)
WANG LONG (CN)
LUO YUFENG (CN)
TANG PINGMING (CN)
YU YAN (CN)
ZHANG CHEN (CN)
YAN PANGKE (CN)
Application Number:
PCT/CN2022/123443
Publication Date:
April 06, 2023
Filing Date:
September 30, 2022
Export Citation:
Assignee:
HAISCO PHARMACEUTICAL GROUP CO LTD (CN)
International Classes:
C07D471/04; A61K31/4375; A61K31/496; A61P35/00; C07D401/14
Domestic Patent References:
| WO2009053373A1 | 2009-04-30 | |||
| WO2021013735A1 | 2021-01-28 | |||
| WO2022222921A1 | 2022-10-27 | |||
| WO2022225934A1 | 2022-10-27 | |||
| WO2021013735A1 | 2021-01-28 |
Foreign References:
| CN102341394A | 2012-02-01 |
Other References:
S. R. SANDLER ET AL.: "Organic Functional Group Preparations", 1983, JOHN WILEY & SONS, INC.
H. O. HOUSE: "Modern Synthetic Reactions", 1972, W. A. BENJAMIN, INC.
PATAI, S., PATAI'S 1992 GUIDE TO THE CHEMISTRY OF FUNCTIONAL GROUPS, 1992
FUHRHOPJ. AND PENZLIN G: "Revised and Enlarged Edition", vol. 3, 1994, JOHN WILEY & SONS, article "Organic Synthesis: Concepts, Methods, Starting Materials", pages: 527 - 29074
HOFFMAN, R.V.: "Organic Chemistry, An Intermediate Text", 1996, OXFORD UNIVERSITY PRESS
LAROCK, R. C.: "Industrial Organic Chemicals: Starting Materials and Intermediates: An Ullmann's Encyclopaedia", 1999, JOHN WILEY & SONS
SOLOMONS, T. W. G.: "Modern Carbonyl Chemistry", 2000, JOHN WILEY & SONS
STOWELL, J.C.: "Intermediate Organic Chemistry", 1993, WILEY-INTERSCIENCE
"Organic Reactions", 1942, JOHN WILEY & SONS
"Chemistry of Functional Groups", vol. 73, JOHN WILEY & SONS
H. O. HOUSE: "Modern Synthetic Reactions", 1972, W. A. BENJAMIN, INC.
PATAI, S., PATAI'S 1992 GUIDE TO THE CHEMISTRY OF FUNCTIONAL GROUPS, 1992
FUHRHOPJ. AND PENZLIN G: "Revised and Enlarged Edition", vol. 3, 1994, JOHN WILEY & SONS, article "Organic Synthesis: Concepts, Methods, Starting Materials", pages: 527 - 29074
HOFFMAN, R.V.: "Organic Chemistry, An Intermediate Text", 1996, OXFORD UNIVERSITY PRESS
LAROCK, R. C.: "Industrial Organic Chemicals: Starting Materials and Intermediates: An Ullmann's Encyclopaedia", 1999, JOHN WILEY & SONS
SOLOMONS, T. W. G.: "Modern Carbonyl Chemistry", 2000, JOHN WILEY & SONS
STOWELL, J.C.: "Intermediate Organic Chemistry", 1993, WILEY-INTERSCIENCE
"Organic Reactions", 1942, JOHN WILEY & SONS
"Chemistry of Functional Groups", vol. 73, JOHN WILEY & SONS
Attorney, Agent or Firm:
CCPIT PATENT AND TRADEMARK LAW OFFICE (CN)
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