Title:
NITROGENOUS TRICYCLIC COMPOUNDS AND USES THEREOF IN MEDICINE
Document Type and Number:
WIPO Patent Application WO/2019/149158
Kind Code:
A1
Abstract:
The present invention relates to nitrogenous tricyclic compounds and uses thereof in medicine, in particular, the present invention discloses a novel nitrogenous tricyclic compound used as an FXR active regulator and a stereoisomer, a geometrical isomer, a tautomer, a N-oxide, a hydrate, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof, and use of the compound in the manufacture of a drug for treating a disease and/or disorder regulated by FXR. The present invention further discloses a pharmacetically acceptable composition containing the compound and a method of treating a disease and/or disorder mediated by FXR comprising administering the compound or pharmaceutical composition thereof disclosed herein.
Inventors:
YANG XINYE (CN)
WANG XIAOJUN (CN)
WU JUNWEN (CN)
CHEN HONG (CN)
CAO SHENGTIAN (CN)
ZHANG YINGJUN (CN)
WANG XIAOJUN (CN)
WU JUNWEN (CN)
CHEN HONG (CN)
CAO SHENGTIAN (CN)
ZHANG YINGJUN (CN)
Application Number:
PCT/CN2019/073303
Publication Date:
August 08, 2019
Filing Date:
January 28, 2019
Export Citation:
Assignee:
SUNSHINE LAKE PHARMA CO LTD (CN)
International Classes:
C07D491/044; A61K31/519; A61K31/55; A61K31/554; A61P7/02; A61P9/10; A61P15/10; C07D471/04; C07D491/056; C07D491/147; C07D498/14
Domestic Patent References:
| WO2000037077A1 | 2000-06-29 | |||
| WO2003015771A1 | 2003-02-27 | |||
| WO2004048349A1 | 2004-06-10 | |||
| WO2007076260A2 | 2007-07-05 | |||
| WO2007092751A2 | 2007-08-16 | |||
| WO2007140174A2 | 2007-12-06 | |||
| WO2007140183A1 | 2007-12-06 | |||
| WO2008051942A2 | 2008-05-02 | |||
| WO2008157270A1 | 2008-12-24 | |||
| WO2009005998A1 | 2009-01-08 | |||
| WO2009012125A1 | 2009-01-22 | |||
| WO2009149795A2 | 2009-12-17 | |||
| WO2008025539A1 | 2008-03-06 | |||
| WO2008025540A1 | 2008-03-06 | |||
| WO2012087520A1 | 2012-06-28 | |||
| WO2012087521A1 | 2012-06-28 | |||
| WO2012087519A1 | 2012-06-28 | |||
| WO2013007387A1 | 2013-01-17 | |||
| WO2015036442A1 | 2015-03-19 | |||
| WO2016127924A1 | 2016-08-18 |
Foreign References:
| CN107686486A | 2018-02-13 | |||
| CN105884758A | 2016-08-24 |
Other References:
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FORMAN ET AL., CELL, vol. 81, 1995, pages 687 - 693
MAKISHIMA ET AL., SCIENCE, vol. 284, 1999, pages 1365 - 1368
WANG ET AL., MOICELL., vol. 3, 1999, pages 543 - 553
URIZAR ET AL., J.BIOL.CHEM., vol. 275, 2000, pages 39313 - 393170
CRAWLEY, EXPERT OPINION THER. PATENTS, vol. 20, 2010, pages 1047 - 1057
FRANK G. SCHAAP ET AL., JOURNAL OF MEDICINAL CHEMISTRY, vol. 48, 2005, pages 5383 - 5402
R.C. BUIJSMAN ET AL., CURR. MED. CHEM., vol. 12, 2005, pages 1017 - 1075
ELIEL, E.WILEN, S.: "Periodic Table of the Elements, CAS version, and the Handbook of Chemistry and Physics", 1994, JOHN WILEY&SONS, INC.
SORRELL ET AL.: "Organic Chemistry", 1999, UNIVERSITY SCIENCE BOOKS
MICHAEL B. SMITHJERRY MARCH: "March's Advanced Organic Chemistry", 2007, JOHN WILEY & SONS
"McGraw-Hill Dictionary of Chemical Terms", 1984, MCGRAW-HILL BOOK COMPANY
BERGE ET AL.: "describe pharmaceutically acceptable salts in detail", J. PHARMACOL SCI, vol. 66, 1977, pages 1 - 19
L. W. DEADY, SYN. COMM., vol. 7, 1977, pages 509 - 514
T. HIGUCHIV STELLA: "A.C.S. Symposium Series", vol. 14, article "Pro-drugs as Novel Delivery Systems"
"Bioreversible Carriers in Drug Design", 1987, AMERICAN PHARMACEUTICAL ASSOCIATION AND PERGAMON PRESS
J. RAUTIO ET AL.: "Prodrugs: Design and Clinical Applications", NATURE REVIEW DRUG DISCOVERY, vol. 7, 2008, pages 255 - 270, XP055227338, DOI: 10.1038/nrd2468
S. J. HECKER ET AL.: "Prodrugs of Phosphates and Phosphonates", JOURNAL OF MEDICINAL CHEMISTRY, vol. 51, 2008, pages 2328 - 2345, XP008148502, DOI: 10.1021/jm701260b
T. W. GREENE: "Protective Groups in Organic Synthesis", 1991, JOHN WILEY & SONS
P. J. KOCIENSKI: "Remington: The Science and Practice of Pharmacy", 2005, LIPPINCOTT WILLIAMS & WILKINS
SWARBRICK ET AL.: "Encyclopedia of Pharmaceutical Technology", MARCEL DEKKER, pages: 19881999
See also references of EP 3746448A4
FORMAN ET AL., CELL, vol. 81, 1995, pages 687 - 693
MAKISHIMA ET AL., SCIENCE, vol. 284, 1999, pages 1365 - 1368
WANG ET AL., MOICELL., vol. 3, 1999, pages 543 - 553
URIZAR ET AL., J.BIOL.CHEM., vol. 275, 2000, pages 39313 - 393170
CRAWLEY, EXPERT OPINION THER. PATENTS, vol. 20, 2010, pages 1047 - 1057
FRANK G. SCHAAP ET AL., JOURNAL OF MEDICINAL CHEMISTRY, vol. 48, 2005, pages 5383 - 5402
R.C. BUIJSMAN ET AL., CURR. MED. CHEM., vol. 12, 2005, pages 1017 - 1075
ELIEL, E.WILEN, S.: "Periodic Table of the Elements, CAS version, and the Handbook of Chemistry and Physics", 1994, JOHN WILEY&SONS, INC.
SORRELL ET AL.: "Organic Chemistry", 1999, UNIVERSITY SCIENCE BOOKS
MICHAEL B. SMITHJERRY MARCH: "March's Advanced Organic Chemistry", 2007, JOHN WILEY & SONS
"McGraw-Hill Dictionary of Chemical Terms", 1984, MCGRAW-HILL BOOK COMPANY
BERGE ET AL.: "describe pharmaceutically acceptable salts in detail", J. PHARMACOL SCI, vol. 66, 1977, pages 1 - 19
L. W. DEADY, SYN. COMM., vol. 7, 1977, pages 509 - 514
T. HIGUCHIV STELLA: "A.C.S. Symposium Series", vol. 14, article "Pro-drugs as Novel Delivery Systems"
"Bioreversible Carriers in Drug Design", 1987, AMERICAN PHARMACEUTICAL ASSOCIATION AND PERGAMON PRESS
J. RAUTIO ET AL.: "Prodrugs: Design and Clinical Applications", NATURE REVIEW DRUG DISCOVERY, vol. 7, 2008, pages 255 - 270, XP055227338, DOI: 10.1038/nrd2468
S. J. HECKER ET AL.: "Prodrugs of Phosphates and Phosphonates", JOURNAL OF MEDICINAL CHEMISTRY, vol. 51, 2008, pages 2328 - 2345, XP008148502, DOI: 10.1021/jm701260b
T. W. GREENE: "Protective Groups in Organic Synthesis", 1991, JOHN WILEY & SONS
P. J. KOCIENSKI: "Remington: The Science and Practice of Pharmacy", 2005, LIPPINCOTT WILLIAMS & WILKINS
SWARBRICK ET AL.: "Encyclopedia of Pharmaceutical Technology", MARCEL DEKKER, pages: 19881999
See also references of EP 3746448A4
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