Title:
NITROIMIDAZOLE-SUPPORTING PORPHYRIN COMPLEX
Document Type and Number:
WIPO Patent Application WO/2001/040233
Kind Code:
A1
Abstract:
A drug which is a porphyrin derivative having a nitroimidazole compound bonded thereto. It takes advantage of the affinity of the porphyrin derivative for cancers. It functions to form an image in magnetic resonance imagination (MRI) and further has a sensitizing function for radiotherapy. Also provided is a porphyrin compound which is applicable to a treatment with a DDS and is free from light toxicity. Specifically, the compound is a porphyrin complex represented by formula (I) or a pharmacologically acceptable salt thereof. [wherein R?1¿ and R?2¿ each represents -CH=CH¿2?, -CH(CH¿3?)OH, or -CH(CH¿3?)O-(CH¿2?)¿n?-NH-R?a¿ (R?a¿ represents hydrogen or a group represented by formula (II) and n and m each is an integer of 2 or 3); R?3¿ represents hydrogen or -CO(CH¿2?)¿m?-CO¿2?H; and M represents a transition metal selected among manganese, iron, cobalt, and copper].
Inventors:
SAKATA ISAO (JP)
NAKAJIMA SUSUMU (JP)
NAKAE YOSHINORI (JP)
NAKAJIMA SUSUMU (JP)
NAKAE YOSHINORI (JP)
Application Number:
PCT/JP2000/008385
Publication Date:
June 07, 2001
Filing Date:
November 29, 2000
Export Citation:
Assignee:
PHOTOCHEMICAL CO LTD (JP)
SAKATA ISAO (JP)
NAKAJIMA SUSUMU (JP)
NAKAE YOSHINORI (JP)
SAKATA ISAO (JP)
NAKAJIMA SUSUMU (JP)
NAKAE YOSHINORI (JP)
International Classes:
A61K41/00; A61K49/06; A61K49/08; A61K49/10; C07D487/22; (IPC1-7): C07D487/22; A61K31/395; A61K49/00; A61P35/00
Foreign References:
| JPH0867682A | 1996-03-12 | |||
| JPH07330773A | 1995-12-19 |
Other References:
See also references of EP 1148057A4
Attorney, Agent or Firm:
Kusama, Osamu (Iwata Bldg. 5-12, Iidabashi 4-chome Chiyoda-ku Tokyo, JP)
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