Title:
NK CELL AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2023/217183
Kind Code:
A1
Abstract:
Provided is an NK cell. The NK cell comprises a CD38 knockout and CD16a-overexpressing polynucleotide. Compared with conventional NK cells, the NK cell has an improved a killing function on a tumor cell line,while killing between NK cells is weakened, the survival rate and the growth rate of cells are improved, and cell depletion is reduced.
Inventors:
ZENG HAOYU (CN)
SHEN ZHENBO (CN)
JIANG BIYU (CN)
ZHAO YANLING (CN)
LI XIAOQING (CN)
SHEN ZHENBO (CN)
JIANG BIYU (CN)
ZHAO YANLING (CN)
LI XIAOQING (CN)
Application Number:
PCT/CN2023/093246
Publication Date:
November 16, 2023
Filing Date:
May 10, 2023
Export Citation:
Assignee:
GUANGDONG PROCAPZOOM BIOSCIENCES CO LTD (CN)
International Classes:
C12N5/10; C12N15/12; C12N15/85; C12N15/867
Domestic Patent References:
| WO2022093901A1 | 2022-05-05 |
Foreign References:
| CN114921416A | 2022-08-19 | |||
| CN109486828A | 2019-03-19 | |||
| CN114457116A | 2022-05-10 | |||
| CN114438129A | 2022-05-06 |
Other References:
WOAN KARRUNE V., KIM HANSOL, BJORDAHL RYAN, DAVIS ZACHARY B., GAIDAROVA SVETLANA, GOULDING JOHN, HANCOCK BRIAN, MAHMOOD SAJID, ABU: "Harnessing features of adaptive NK cells to generate iPSC-derived NK cells for enhanced immunotherapy", CELL STEM CELL, ELSEVIER, CELL PRESS, AMSTERDAM, NL, vol. 28, no. 12, 1 December 2021 (2021-12-01), AMSTERDAM, NL , pages 2062 - 2075.e5, XP093109255, ISSN: 1934-5909, DOI: 10.1016/j.stem.2021.08.013
SHI RUIFANG; YAO LU; JIA SHAOCHANG: "CAR-NK: A New Strategy for Tumor Immunocyte Therapy", CHINESE JOURNAL OF CANCER BIOTHERAPY, PUBLISHING HOUSE OF CHINESE JOURNAL OF CANCER BIOTHERAPY, CN, vol. 27, no. 4, 25 April 2020 (2020-04-25), CN , pages 440 - 444, XP009550673, ISSN: 1007-385X, DOI: 10.3872/j.issn.1007-385x.2020.04.016
SHI RUIFANG; YAO LU; JIA SHAOCHANG: "CAR-NK: A New Strategy for Tumor Immunocyte Therapy", CHINESE JOURNAL OF CANCER BIOTHERAPY, PUBLISHING HOUSE OF CHINESE JOURNAL OF CANCER BIOTHERAPY, CN, vol. 27, no. 4, 25 April 2020 (2020-04-25), CN , pages 440 - 444, XP009550673, ISSN: 1007-385X, DOI: 10.3872/j.issn.1007-385x.2020.04.016
Attorney, Agent or Firm:
SCIHEAD IP LAW FIRM et al. (CN)
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