Title:
NLRP3 INFLAMMASOME INHIBITOR AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/253326
Kind Code:
A1
Abstract:
The present invention relates to the technical field of medicine, and relates to an NLRP3 inflammasome inhibitor and an application thereof. The present invention particularly relates to a compound represented by general formula (I) or a pharmaceutically acceptable salt, a stereoisomer, or a tautomer thereof. The definitions of different groups are as defined in the description. Research shows that the compound represented by general formula (I) or the pharmaceutically acceptable salt, the stereoisomer, or the tautomer thereof has high biological activity on an NLRP3 inflammasome and has a significant clinical development value for the treatment of NLRP3-related diseases.
Inventors:
LI LIN (CN)
WU FRANK (CN)
WU FRANK (CN)
Application Number:
PCT/CN2022/096928
Publication Date:
December 08, 2022
Filing Date:
June 02, 2022
Export Citation:
Assignee:
TRANSTHERA SCIENCES NANJING INC (CN)
International Classes:
C07D401/12; A61K31/502; A61P1/16; A61P3/10; A61P9/00; A61P9/10; A61P9/12; A61P13/12; A61P17/00; A61P17/02; A61P19/06; A61P19/08; A61P25/00; A61P25/28; A61P27/02; A61P29/00; A61P31/04; A61P35/00; A61P35/02; A61P37/00; A61P37/02; A61P37/06; A61P43/00
Domestic Patent References:
| WO2022135567A1 | 2022-06-30 | |||
| WO2018221433A1 | 2018-12-06 | |||
| WO2018080216A1 | 2018-05-03 | |||
| WO2020234715A1 | 2020-11-26 |
Foreign References:
| US11319319B1 | 2022-05-03 | |||
| CN1984904A | 2007-06-20 | |||
| US20180093956A1 | 2018-04-05 | |||
| US20090124624A1 | 2009-05-14 | |||
| US3753988A | 1973-08-21 |
Other References:
KASSAB, E. A.: "Synthesis and behaviour of 4-(4'-chloro-3'-methylphenyl)-1(2H)- phthalazinone towards certain electrophiles and nucleophiles", EGYPTIAN JOURNAL OF CHEMISTRY, vol. 48, 1 January 2005 (2005-01-01), Cairo , pages 183 - 199, XP009086292, ISSN: 0449-2285
DATABASE REGISTRY 26 March 2018 (2018-03-26), ANONYMOUS : "Cyclopentanecarboxylic acid, 3-hydroxy-4-[[4-(4-methoxyphenyl)-1- phthalazinyl]amino]- (CA INDEX NAME)", XP093011873, retrieved from STN Database accession no. 2198981-59-6
DATABASE REGISTRY 23 June 2011 (2011-06-23), ANONYMOUS: "1-Phthalazinamine, 4-(4-methylphenyl)-N-3-pyrrolidinyl- (CA INDEX NAME)", XP093011874, retrieved from STN Database accession no. 1310214-26-6
DATABASE REGISTRY 10 March 2011 (2011-03-10), ANONYMOUS : "1-Phthalazinamine, 4-(4-fluorophenyl)-N-3-pyrrolidinyl- (CA INDEX NAME)", XP093011876, retrieved from STN Database accession no. 1267866-53-4
DATABASE REGISTRY 9 September 2009 (2009-09-09), ANONYMOUS : "Benzamide, 4-[4-(cyclopentylamino)-1-phthalazinyl]- (CA INDEX NAME)", XP093011881, retrieved from STN Database accession no. 1181498-12-3
DATABASE REGISTRY 22 June 2005 (2005-06-22), ANONYMOUS: "1-Phthalazinamine, N-cycloheptyl-4-(4-methylphenyl)- (CA INDEX NAME)", XP093011885, retrieved from STN Database accession no. 852664-73-4
DATABASE REGISTRY 17 June 2004 (2004-06-17), ANONYMOUS: "Phthalazine, 1-(cyclohexyloxy)-4-(4-methylphenyl)- (CA INDEX NAME)", XP093011886, retrieved from STN Database accession no. 694474-51-6
DATABASE REGISTRY 6 September 2002 (2002-09-06), ANONYMOUS: "1-Phthalazinamine, 4-(4-chlorophenyl)-N-cyclohexyl- (CA INDEX NAME)", XP093011888, retrieved from STN Database accession no. 447430-65-1
DATABASE REGISTRY 6 September 2002 (2002-09-06), ANONYMOUS: "1-Phthalazinamine, N-cyclohexyl-4-(4-fluorophenyl)- (CA INDEX NAME)", XP093011889, retrieved from STN Database accession no. 447430-63-9
DATABASE REGISTRY 6 September 2002 (2002-09-06), ANONYMOUS: "1-Phthalazinamine, N-cyclohexyl-4-(2,5-dimethylphenyl)- (CA INDEX NAME)", XP093011893, retrieved from STN Database accession no. 447430-62-8
DATABASE REGISTRY 6 September 2002 (2002-09-06), ANONYMOUS : "1-Phthalazinamine, N-cyclohexyl-4-(2,4-dimethylphenyl)- (CA INDEX NAME)", XP093011894, retrieved from STN Database accession no. 447430-60-6
DATABASE REGISTRY 6 September 2002 (2002-09-06), ANONYMOUS: "1-Phthalazinamine, N-cyclohexyl-4-(4-methylphenyl)- (CA INDEX NAME)", XP093011896, retrieved from STN Database accession no. 447430-58-2
DATABASE REGISTRY 6 September 2002 (2002-09-06), ANONYMOUS: "1-Phthalazinamine, N-cyclohexyl-4-(3,4-dimethylphenyl)- (CA INDEX NAME)", XP093011898, retrieved from STN Database accession no. 447430-57-1
DATABASE REGISTRY 26 March 2018 (2018-03-26), ANONYMOUS : "Cyclopentanecarboxylic acid, 3-hydroxy-4-[[4-(4-methoxyphenyl)-1- phthalazinyl]amino]- (CA INDEX NAME)", XP093011873, retrieved from STN Database accession no. 2198981-59-6
DATABASE REGISTRY 23 June 2011 (2011-06-23), ANONYMOUS: "1-Phthalazinamine, 4-(4-methylphenyl)-N-3-pyrrolidinyl- (CA INDEX NAME)", XP093011874, retrieved from STN Database accession no. 1310214-26-6
DATABASE REGISTRY 10 March 2011 (2011-03-10), ANONYMOUS : "1-Phthalazinamine, 4-(4-fluorophenyl)-N-3-pyrrolidinyl- (CA INDEX NAME)", XP093011876, retrieved from STN Database accession no. 1267866-53-4
DATABASE REGISTRY 9 September 2009 (2009-09-09), ANONYMOUS : "Benzamide, 4-[4-(cyclopentylamino)-1-phthalazinyl]- (CA INDEX NAME)", XP093011881, retrieved from STN Database accession no. 1181498-12-3
DATABASE REGISTRY 22 June 2005 (2005-06-22), ANONYMOUS: "1-Phthalazinamine, N-cycloheptyl-4-(4-methylphenyl)- (CA INDEX NAME)", XP093011885, retrieved from STN Database accession no. 852664-73-4
DATABASE REGISTRY 17 June 2004 (2004-06-17), ANONYMOUS: "Phthalazine, 1-(cyclohexyloxy)-4-(4-methylphenyl)- (CA INDEX NAME)", XP093011886, retrieved from STN Database accession no. 694474-51-6
DATABASE REGISTRY 6 September 2002 (2002-09-06), ANONYMOUS: "1-Phthalazinamine, 4-(4-chlorophenyl)-N-cyclohexyl- (CA INDEX NAME)", XP093011888, retrieved from STN Database accession no. 447430-65-1
DATABASE REGISTRY 6 September 2002 (2002-09-06), ANONYMOUS: "1-Phthalazinamine, N-cyclohexyl-4-(4-fluorophenyl)- (CA INDEX NAME)", XP093011889, retrieved from STN Database accession no. 447430-63-9
DATABASE REGISTRY 6 September 2002 (2002-09-06), ANONYMOUS: "1-Phthalazinamine, N-cyclohexyl-4-(2,5-dimethylphenyl)- (CA INDEX NAME)", XP093011893, retrieved from STN Database accession no. 447430-62-8
DATABASE REGISTRY 6 September 2002 (2002-09-06), ANONYMOUS : "1-Phthalazinamine, N-cyclohexyl-4-(2,4-dimethylphenyl)- (CA INDEX NAME)", XP093011894, retrieved from STN Database accession no. 447430-60-6
DATABASE REGISTRY 6 September 2002 (2002-09-06), ANONYMOUS: "1-Phthalazinamine, N-cyclohexyl-4-(4-methylphenyl)- (CA INDEX NAME)", XP093011896, retrieved from STN Database accession no. 447430-58-2
DATABASE REGISTRY 6 September 2002 (2002-09-06), ANONYMOUS: "1-Phthalazinamine, N-cyclohexyl-4-(3,4-dimethylphenyl)- (CA INDEX NAME)", XP093011898, retrieved from STN Database accession no. 447430-57-1
Attorney, Agent or Firm:
LINDA LIU & PARTNERS (CN)
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