Title:
NLRP3 INFLAMMASOME INHIBITOR AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING INFLAMMATORY DISEASE
Document Type and Number:
WIPO Patent Application WO/2021/177332
Kind Code:
A1
Abstract:
An NLRP3 inflammasome inhibitor containing a cephem compound as an active ingredient.
Inventors:
NOGUCHI TAKUYA (JP)
MATSUZAWA ATSUSHI (JP)
MATSUZAWA ATSUSHI (JP)
Application Number:
PCT/JP2021/008060
Publication Date:
September 10, 2021
Filing Date:
March 03, 2021
Export Citation:
Assignee:
UNIV TOHOKU (JP)
International Classes:
A61K31/545; A61P3/10; A61P19/02; A61P19/06; A61P29/00
Foreign References:
| JPH04338392A | 1992-11-25 |
Other References:
GUO, CHUNQING ET AL.: "Development and Characterization of a Hydroxyl-Sulfonamide Analogue, 5- Chloro-N-[2-(4-hydroxysulfamoyl- phenyl)-ethyl]-2-methoxy-benzamide, as a Novel NLRP3 Inflammasome Inhibitor for Potential Treatment of Multiple Sclerosis", ACS CHEM. NEUROSCI., vol. 8, 2017, pages 2194 - 2201, XP055509994, DOI: 10.1021/acschemneuro.7b00124
GAO, RIFENG ET AL.: "The selective NLRP3- inflammasome inhibitor MCC950 reduces myocardial fibrosis and improves cardiac remodeling in a mouse model of myocardial infarction", INTERNATIONAL IMMUNOPHARMACOLOGY, vol. 74, 2019, pages 105575, XP085785388, DOI: 10.1016/j.intimp.2019.04.022
SHIMOZONO, TAKURO ET AL.: "Why it used in combination with other antibiotics "Cephem antibiotic"", THE JOURNAL OF PRACTICAL PHARMACY, vol. 54, no. 3, 2003, pages 1441 - 1457
MITSUTAKE, KIYOFUMI ET AL.: "A case of chronic recurrent multifocal osteomyelitis", ORTHOPEDICS & TRAUMATOLOGY, vol. 62, no. 1, 2013, pages 32 - 37
GAO, RIFENG ET AL.: "The selective NLRP3- inflammasome inhibitor MCC950 reduces myocardial fibrosis and improves cardiac remodeling in a mouse model of myocardial infarction", INTERNATIONAL IMMUNOPHARMACOLOGY, vol. 74, 2019, pages 105575, XP085785388, DOI: 10.1016/j.intimp.2019.04.022
SHIMOZONO, TAKURO ET AL.: "Why it used in combination with other antibiotics "Cephem antibiotic"", THE JOURNAL OF PRACTICAL PHARMACY, vol. 54, no. 3, 2003, pages 1441 - 1457
MITSUTAKE, KIYOFUMI ET AL.: "A case of chronic recurrent multifocal osteomyelitis", ORTHOPEDICS & TRAUMATOLOGY, vol. 62, no. 1, 2013, pages 32 - 37
Attorney, Agent or Firm:
SAEGUSA & PARTNERS (JP)
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