N,N-DIPHENYLAMINO-MODIFIED β-CARBOLINE INDOLIUM SALT, PREPARATION METHOD AND USE

WIPO Patent Application WO/2023/029638

A1

The present invention relates to the field of biological medicines, and relates to an N,N-diphenylamino-modified β-carboline indolium salt, a preparation method and the use. The β-carboline indolium salt has a structure as represented by general formula (I), can be activated in the acidic microenvironment of tumor tissue by the ICT principle, and selectively and rapidly generates pH-sensitive near-infrared fluorescence at a tumor site. The specific implementation method comprises: spraying or locally injecting a solution of the β-carboline indoliumm salt of the present invention onto/into a tumor lesion site and the surrounding tissue, and performing rapid and selective fluorescence imaging and tracing on the tumor lesion tissue by means of using a fluorescence endoscope or an in vivo imager. The method has a relatively high tumor tissue fluorescence imaging selectivity and a relatively low background fluorescence interference, and can be used for accurately detecting tumors.

LING YONG (CN)
YANG YUMIN (CN)
LI PENG (CN)
QIAN JIANQIANG (CN)
MENG CHI (CN)
ZHANG YAN'AN (CN)
XU ZHONGYUAN (CN)
DING QIAN (CN)
MIAO DAOXIN (CN)
ZHANG YUTING (CN)

PCT/CN2022/097845

March 09, 2023

June 09, 2022

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UNIV NANTONG (CN)

C07D471/04; A61K49/00; C09K11/06

CN113717169A	2021-11-30
CN111943948A	2020-11-17
CN111196922A	2020-05-26
CN111875603A	2020-11-03

NANJING IPLEADER INTELLECTUAL PROPERTY AGENCY FIRM (CN)

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