Title:
NOD2 NUCLEIC ACIDS AND PROTEINS
Document Type and Number:
WIPO Patent Application WO2002036773
Kind Code:
A3
Abstract:
The present invention relates to intracellular signaling molecules, in particular the Nod2 protein and nucleic acids encoding the Nod2 protein. The present invention provides isolated nucleotide sequence encoding Nod2, isolated Nod2 peptides, antibodies that specifically bind Nod2, methods for the detection of Nod2, and methods for screening compounds for the ability to alter Nod2 associated signal transduction.
Inventors:
NUNEZ GABRIEL (US)
INOHARA NAOHIRO (US)
OGURA YASUNORI (US)
INOHARA NAOHIRO (US)
OGURA YASUNORI (US)
Application Number:
PCT/US2001/047699
Publication Date:
March 13, 2003
Filing Date:
October 26, 2001
Export Citation:
Assignee:
UNIV MICHIGAN (US)
NUNEZ GABRIEL (US)
INOHARA NAOHIRO (US)
OGURA YASUNORI (US)
NUNEZ GABRIEL (US)
INOHARA NAOHIRO (US)
OGURA YASUNORI (US)
International Classes:
C07K14/47; C12N1/21; C12N15/12; (IPC1-7): C12N15/12; C07K14/47; C12N1/21; C12N5/04; C12N5/10; C12N15/11; C12Q1/68; G01N33/68
Domestic Patent References:
| WO1999064576A2 | 1999-12-16 | |||
| WO1999040102A1 | 1999-08-12 | |||
| WO2001072822A2 | 2001-10-04 | |||
| WO2001090156A2 | 2001-11-29 |
Other References:
DATABASE EMBL [online] 7 June 1999 (1999-06-07), BRUCE D. ET AL.: "Sequencing ofSequencing of Human Chromosome 16", XP002222978, retrieved from EBI Database accession no. ac007728
DATABASE EMBL [online] 18 May 1999 (1999-05-18), ZHAO S. ET AL.: "Use of BAC End Sequences from Library RPCI-11 for Sequence-Ready Map Building", XP002222979, retrieved from EBI Database accession no. AQ534686
INOHARA NAOHIRO ET AL: "The NOD: A signaling module that regulates apoptosis and host defense against pathogens.", ONCOGENE, vol. 20, no. 44, 2001, pages 6473 - 6481, XP009001967, ISSN: 0950-9232
OGURA ET AL: "Nod2, a Nod1/Apaf-1 Family Member That Is Restricted to Monocytes and Activates NF-kappa B", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 276, no. 7, 16 February 2001 (2001-02-16), pages 4812 - 4818, XP002177307, ISSN: 0021-9258
INOHARA NAOHIRO ET AL: "Nods: A family of cytosolic proteins that regulate the host response to pathogens.", CURRENT OPINION IN MICROBIOLOGY, vol. 5, no. 1, February 2002 (2002-02-01), pages 76 - 80, XP002222977, ISSN: 1369-5274
DATABASE EMBL [online] 18 May 1999 (1999-05-18), ZHAO S. ET AL.: "Use of BAC End Sequences from Library RPCI-11 for Sequence-Ready Map Building", XP002222979, retrieved from EBI Database accession no. AQ534686
INOHARA NAOHIRO ET AL: "The NOD: A signaling module that regulates apoptosis and host defense against pathogens.", ONCOGENE, vol. 20, no. 44, 2001, pages 6473 - 6481, XP009001967, ISSN: 0950-9232
OGURA ET AL: "Nod2, a Nod1/Apaf-1 Family Member That Is Restricted to Monocytes and Activates NF-kappa B", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 276, no. 7, 16 February 2001 (2001-02-16), pages 4812 - 4818, XP002177307, ISSN: 0021-9258
INOHARA NAOHIRO ET AL: "Nods: A family of cytosolic proteins that regulate the host response to pathogens.", CURRENT OPINION IN MICROBIOLOGY, vol. 5, no. 1, February 2002 (2002-02-01), pages 76 - 80, XP002222977, ISSN: 1369-5274
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