Title:
NON-AGGREGATING IMMUNOSTIMULATORY OLIGONUCLEOTIDES
Document Type and Number:
WIPO Patent Application WO/2016/103703
Kind Code:
A1
Abstract:
Provided are non-aggregating immunostimulatory oligonucleotides. The present invention also provides a delivery agent for an immunostimulatory-oligonucleotide nucleic acid medicine, said delivery agent including a nucleic acid that contains a phosphorothioated nucleotide. According to another aspect, the present invention further provides an oligonucleotide including a bioactive core, and a nucleic acid that contains a phosphorothioated nucleotide. The present invention yet further provides an immunostimulator including the bioactive core of a type A/D, type B/K, or type C immunostimulatory oligonucleotide.
Inventors:
ISHII KEN (JP)
AOSHI TAIKI (JP)
SATO HIDEAKI (JP)
AOSHI TAIKI (JP)
SATO HIDEAKI (JP)
Application Number:
PCT/JP2015/006435
Publication Date:
June 30, 2016
Filing Date:
December 24, 2015
Export Citation:
Assignee:
NAT INST OF BIOMEDICAL INNOVATION HEALTH AND NUTRITION (JP)
GENEDESIGN INC (JP)
GENEDESIGN INC (JP)
International Classes:
A61K31/7088; A61K9/127; A61P37/04; C12N15/09
Domestic Patent References:
| WO2000061151A2 | 2000-10-19 | |||
| WO2001051500A1 | 2001-07-19 | |||
| WO2007139190A1 | 2007-12-06 |
Foreign References:
| JP2009035530A | 2009-02-19 |
Other References:
See also references of EP 3238727A4
Attorney, Agent or Firm:
YAMAMOTO, Shusaku et al. (JP)
Shusaku Yamamoto (JP)
Shusaku Yamamoto (JP)
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