Title:
NON-CALCEMIC, ANTIPROLIFERATIVE, TRANSCRIPTIONALLY ACTIVE SULFUR-CONTAINING ANALOGS OF 1 alpha , 25-DIHYDROXY VITAMIN D3
Document Type and Number:
WIPO Patent Application WO2000059513
Kind Code:
A8
Abstract:
Novel sulfur-containing analogs of 1 alpha ,25- dihydroxyvitamin D3 are provided. These analogs are synthesized in a convergent manner by joining A-ring and C,D ring fragments. Each analog with 1 alpha ,3 beta -substituent stereochemistry shows a pharmacologically desirable combination of high antiproliferative and high transcriptional activities in vitro and also low calcemic activity in vivo.
Inventors:
POSNER GARY H (US)
LEE JAE KYOO
WANG QIANG
CRAWFORD KENNETH R
HAN GYOONHEE
LEE JAE KYOO
WANG QIANG
CRAWFORD KENNETH R
HAN GYOONHEE
Application Number:
PCT/US2000/008462
Publication Date:
February 15, 2001
Filing Date:
March 31, 2000
Export Citation:
Assignee:
POSNER GARY H (US)
International Classes:
A61K31/593; A61P3/02; A61K31/59; A61P17/08; A61P35/00; A61P43/00; C07B53/00; C07C313/04; C07C317/08; C07C401/00; C07J9/00; (IPC1-7): A61K31/593; C07C401/00
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