Title:
NON-COVALENT INHIBITORS OF UROKINASE AND BLOOD VESSEL FORMATION
Document Type and Number:
WIPO Patent Application WO2002014349
Kind Code:
A3
Abstract:
Novel compounds having activity as non-covalent inhibitors of urokinase and having activity in reducing or inhibiting blood vessel formation are provided. These compounds have P1 a group having an amidino or guanidino moiety or derivative thereof. These compounds are useful in vitro for monitoring plasminogen activator levels and in vivo in treatment of conditions which are ameliorated by inhibition of or decreased activity of urokinase and in treating pathologic conditions wherein blood vessel formation is related to a pathologic condition.
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Inventors:
LEVY ODILE ESTHER (US)
MADISON EDWIN L (US)
SEMPLE JOSEPH EDWARD (US)
TAMIZ AMIR P (US)
WEINHOUSE MICHAEL I (US)
MADISON EDWIN L (US)
SEMPLE JOSEPH EDWARD (US)
TAMIZ AMIR P (US)
WEINHOUSE MICHAEL I (US)
Application Number:
PCT/US2001/025337
Publication Date:
October 03, 2002
Filing Date:
August 10, 2001
Export Citation:
Assignee:
CORVAS INT INC (US)
LEVY ODILE ESTHER (US)
MADISON EDWIN L (US)
SEMPLE JOSEPH EDWARD (US)
TAMIZ AMIR P (US)
WEINHOUSE MICHAEL I (US)
LEVY ODILE ESTHER (US)
MADISON EDWIN L (US)
SEMPLE JOSEPH EDWARD (US)
TAMIZ AMIR P (US)
WEINHOUSE MICHAEL I (US)
International Classes:
A61K38/00; A61P1/04; A61P7/06; C12N9/99; A61P9/00; A61P9/10; A61P17/02; A61P17/06; A61P19/02; A61P27/02; A61P27/06; A61P29/00; A61P31/04; A61P31/10; A61P35/00; A61P35/02; A61P35/04; A61P37/02; A61P43/00; C07K5/06; C07K5/062; C07K5/078; (IPC1-7): C07K5/062; C07K5/06; A61K38/05
Domestic Patent References:
| WO2001096286A2 | 2001-12-20 | |||
| WO2001096366A2 | 2001-12-20 | |||
| WO1996017860A1 | 1996-06-13 | |||
| WO2000061608A2 | 2000-10-19 | |||
| WO2000005245A2 | 2000-02-03 |
Foreign References:
| EP0601459A2 | 1994-06-15 | |||
| US5932567A | 1999-08-03 | |||
| EP0669317A1 | 1995-08-30 |
Other References:
TAMURA^@? S Y ET AL: "Synthesis and biological activity of peptidyl aldehyde urokinase inhibitors", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, OXFORD, GB, vol. 10, no. 9, May 2000 (2000-05-01), pages 983 - 987, XP004199057, ISSN: 0960-894X
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