Title:
NON-HYDROLYZABLE ANALOGS OF HEROIN METABOLITES SUITABLE FOR USE IN IMMUNOASSAY
Document Type and Number:
WIPO Patent Application WO2000078763
Kind Code:
A3
Abstract:
Novel chemical analogs are disclosed for the essential heroin metabolite 6-O-acetyl morphine (6MAM). The analogs optionally can be made to contain protein reactive groups, and can be used to form protein conjugates, fluorescently labeled compounds, and solid-phase adsorbants. The proteins conjugates can be used in turn to raise antibodies reactive with 6MAM and having a low cross-reactivity with the closely related opiates, morphine and codeine. The antibodies can be used in combination with labeled analogs in exquisitely sensitive immunoassays suitable for testing for heroin abuse.
Inventors:
SIGLER GERALD F
ROUHANI RIAZ
ROUHANI RIAZ
Application Number:
PCT/US2000/040234
Publication Date:
March 22, 2001
Filing Date:
June 16, 2000
Export Citation:
Assignee:
MICROGENICS CORP (US)
International Classes:
C07D489/00; C07D489/02; C07F9/6561; G01N33/94; (IPC1-7): C07D489/00; C07D489/02; C07F9/6561; C07K16/44; C07K17/00; C12N11/00; G01N33/94
Domestic Patent References:
| WO1993020079A1 | 1993-10-14 |
Foreign References:
| EP0254120A2 | 1988-01-27 | |||
| US5618926A | 1997-04-08 |
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